Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| changes in number and density of large granular lymphocytes upon in vivo augmentation of mouse natural killer activity. | nk activity of mice as well as humans and rats has been clearly associated with large granular lymphocytes (lgl). to better understand the effects of interferon (ifn) and ifn inducers on natural killer (nk) cells, we have compared the lgl in the spleens of normal and boosted mice. cells were fractionated by centrifugation on discontinuous percoll density gradients, and each fraction was tested for nk activity against yac-1 targets and for the presence of lgl. in vivo treatment with c. parvum (0. ... | 1985 | 2579157 |
| immunologic aspects of gynecologic cancer. | 1985 | 2579358 | |
| recent developments in immunomodulatory therapy. | 1985 | 2579994 | |
| attempts to correlate interferon induction and activation of natural killer cells by corynebacterium parvum. | intraperitoneal (i.p.) injection of poly i:poly c resulted in high interferon titers in the peritoneal wash fluid and in the serum of mice, which was maximal at 4 to 6 h after injection. in contrast, no interferon could be measured in the peritoneal fluid at various times after injection of c. parvum. also, all attempts to induce serum interferon by c. parvum were unsuccessful. however, both poly i:poly c and c. parvum were causing the activation of natural killer (nk) cells in the cell populati ... | 1985 | 2408996 |
| comparison of the neovascular effects of stimulated macrophages and neutrophils in autologous rabbit corneas. | the ability of peritoneal exudate macrophages and neutrophils to induce neovascularization was tested in autologous rabbit corneas. macrophages and neutrophils elicited by proteose peptone or glycogen and macrophages activated by c parvum were purified, pelleted, and implanted 1-2 mm from the corneal limbus. neovascular responses were evaluated by daily slit-lamp observations and terminal whole-mount and histologic examinations of colloidal carbon-perfused vessels. pellets of elicited macrophage ... | 1985 | 2409810 |
| interferon inducibility in mice treated with corynebacterium parvum. | mice were given single intraperitoneal (i.p.) injections of corynebacterium parvum, followed, after different time intervals, by i.p. injections of the interferon inducers polyinosinic-polycytidylic acid (poly-i:poly-c), 10-carboxymethyl-9-acridanone (cma) or herpes simplex virus. with all three inducers production of interferon in the peritoneal cavity was enhanced in c. parvum-pretreated mice. production of circulating interferon in c. parvum-pretreated mice was enhanced with cma and depressed ... | 1985 | 2409917 |
| hyporesponsiveness to augmentation of murine natural killer cell activity in different anatomical compartments by multiple injections of various immunomodulators including recombinant interferons and interleukin 2. | augmentation of natural killer (nk) cell activity has been observed after the single administration of a wide variety of biological response modifiers (brm); however, multiple injections of brm have resulted in hyporesponsiveness to nk augmentation in both preclinical and clinical studies. in these studies, hyporesponsiveness to augmentation of nk cell activity occurred after multiple injections of interferon (ifn recombinant human ifn-alpha a/d and recombinant ifn-gamma) and interleukin 2 and w ... | 1985 | 2411797 |
| comparative study of chemotherapy and/or immunotherapy of established experimental brain tumors. | 1985 | 2415843 | |
| enzyme production of propionibacteria from patients with acne vulgaris and healthy persons. | 375 strains of propionibacteria isolated from pustules, comedones, and from normal skin of patients with acne vulgaris and from healthy persons have been examined for their enzymatic activity. in contrast to healthy individuals, protease and caseinase production of strains from acne patients was significantly lower. on the other hand, dna'ase production of strains from acne lesions was increased, and lecithinase could be demonstrated in strains from acne patients only. | 1985 | 2416168 |
| bacterial products as immunomodulating agents. | 1985 | 2858453 | |
| adverse effect of intrapleural corynebacterium parvum as adjuvant therapy in resected stage i and ii non-small cell carcinoma of the lung. ludwig lung cancer study group. | intrapleural corynebacterium parvum 7 mg or placebo was administered postoperatively as adjuvant therapy to patients with resected stage i and ii non-small cell lung cancer in a prospective, randomized, multicenter trial. a total of 475 patients were entered into this study between july, 1977, and february, 1979. of this group, 405 can be evaluated, with an average follow-up time of 4.6 years. more side effects, especially fever and chest pain, were observed in patients receiving corynebacterium ... | 1985 | 2860271 |
| the involvement of dendritic cells in the handling of the immune stimulant c. parvum. a morphological investigation using immunoperoxidase techniques. | in earlier experiments we showed that locally administered corynebacterium parvum (c. parvum) stimulated the t-cell system and had a beneficial effect on the recurrence rate of surgically resected cancers of the uterine cervix. in this paper we report the use of an immunoperoxidase technique to trace c. parvum antigen in the draining lymph nodes. in a guinea pig model the popliteal lymph node was studied after the injection of 70 micrograms of c. parvum in the hind footpad. at 6 h, intact bacter ... | 1985 | 2861687 |
| comparative in-vitro activity of sch 34343 and other antimicrobial agents against anaerobic bacteria. | the activity of sch 34343 was determined against 575 strains of anaerobic bacteria by an agar-dilution method. its activity was compared with that of benzylpenicillin, piperacillin, cefoxitin, imipenem, clindamycin, metronidazole, chloramphenicol, vancomycin, fusidic acid and bacitracin. sch 34343 and imipenem were the most active agents tested. based on these results, sch 34343 appears to be a promising antimicrobial agent for anaerobic infections and warrants further clinical investigations. | 1985 | 2863246 |
| reverse effect of gram-positive bacteria vs. gram-negative bacteria on adjuvant-induced arthritis in germfree rats. | germfree (gf) f344 rats developed severe adjuvant-induced arthritis with a 100% incidence after a single intradermal injection of heat-killed mycobacterium bovis (bcg). specific pathogene-free (spf) rats developed less severe arthritis with a lower incidence. the rats colonized with escherichia coli or bacteroides developed mild disease comparable to that in spf rats. the rats colonized with bifidobacterium, propionibacterium acnes, lactobacillus casei, l. fermentum, l. murini, and l. acidophilu ... | 1985 | 2931580 |
| acne vulgaris. treatments and their rationale. | 1985 | 2932686 | |
| the effect of bone marrow depletion on prostaglandin e-producing suppressor macrophages in mouse spleen. | the i.p. injection of corynebacterium parvum (cp) into cba/j mice effected increases in macrophage colony-forming cells (m-cfc) when spleen cells were cultured with l cell culture filtrate as a source of colony-stimulating factor. significant increases in phagocytic macrophages (m phi) with fc receptors for igg2a and igg2b immune complexes were additionally noted among the spleen cells in these mice. these m phi effectively inhibited con a-induced lymphocyte proliferation, probably reflecting a ... | 1985 | 2933455 |
| reaction of the thymus and the bursa of fabricius in chickens inoculated with corynebacterium parvum. | 1985 | 2940837 | |
| activation of mouse macrophages causes no change in expression and function of phorbol diesters' receptors, but is accompanied by alterations in the activity and kinetic parameters of nadph oxidase. | mouse peritoneal macrophages activated in vivo by the injection of corynebacterium parvum release larger amounts of superoxide anion (o2-) than macrophages from control mice when stimulated with phorbol myristate acetate (pma). the biochemical bases for this enhanced response of activated macrophages have been investigated by studying the expression and function of receptors for the stimulant, and the activity of the enzyme nadph oxidase which is responsible for the production of o2- in leucocyt ... | 1985 | 2981767 |
| susceptibility of propionibacterium acnes to killing and degradation by human neutrophils and monocytes in vitro. | propionibacterium acnes, the target of inflammation in acne, was tested for its sensitivity to the bactericidal and degradative functions of human polymorphonuclear leukocytes (pmn), monocytes, and their fractions. p. acnes strains were not killed by pmn under any conditions and were variably killed by monocytes in the presence of serum from acne patients. control strains of staphylococcus aureus and micrococcus lysodeicticus were susceptible to both pmn and monocyte killing. p. acnes strains we ... | 1985 | 2989178 |
| oxygen-derived free radicals promote hepatic injury in the rat. | we have investigated the possible protective effect of superoxide dismutase and allopurinol in a rat model of mild and severe hepatic necrosis produced by corynebacterium parvum with or without endotoxin. histology showed a sinusoidal mononuclear cell infiltrate with multiple granulomata but variable degrees of hepatic necrosis. in the severe hepatic injury model there was a reduction in mortality, associated with a decrease in histologic and biochemical evidence of hepatic necrosis, after treat ... | 1985 | 2995189 |
| [cutaneous effects in hormonal contraception]. | oral contraceptives (ocs) can affect the skin through their hormonal effects or through iatrogenic effects associated with their toxicity in certain individuals. they may also be beneficial in certain androgen-dependent dermatoses. toxic effects of ocs are rare but potentially serious; they should be diagnosed early and require permanent termination of oc use. the clinical manifestations are variable and not specific to the medication. the most frequently reported manifestations are allergic ... | 1985 | 12281276 |
| protease production by microorganisms associated with reproductive tract infection. | factors influencing pathogenicity of various microbes found in the female lower genital tract remain incompletely understood. protease production by cervico/vaginal microorganisms may alter or inactivate a variety of proteins important in host defense and structural-functional integrity including collagen-containing chorioamniotic membranes and uterine cervix. host tissues may be made more susceptible to other organisms' virulence factors by protease-producing members of genital tract local flor ... | 1986 | 3004213 |
| deficient ifn alpha production in hairy cell leukemia. | since the application of low doses of ifn-alpha is necessary to maintain remissions in hairy cell leukemia (hcl) it is of interest whether peripheral blood mononuclear cells (mnc) of hcl patients can be induced in vitro to produce ifn-alpha. 9 patients suffering from advanced hcl were included in the study. the diagnoses were confirmed by characteristic findings in peripheral blood and bone marrow biopsies. for ifn treatment we initially used natural ifn-alpha (bioferon) and switched later to re ... | 1986 | 3006840 |
| distribution of intrapleural and intravenous corynebacterium parvum in humans; 99mtc-, and 131i-labeled bacteria. | the distribution of corynebacterium parvum labeled with 131iodine or 99mtechnetium was studied in 17 patients with bronchogenic carcinoma. the labeled bacteria were given intravenously or intrapleurally and monitored by whole-body gamma tracking and samples of blood and urine. even though the rate of physical decay is quite different for 131iodine and 99mtechnetium, the tracking time of labeled bacteria was limited to 24 h after injection for both radioactive isotopes. technetium labeling was pr ... | 1986 | 3011262 |
| protection of mice against herpes simplex virus infection by a lactobacillus casei preparation (lc 9018) in combination with inactivated viral antigen. | heat-killed lactobacillus casei yit 9018 (lc 9018) cells enhanced the resistance to herpes simplex virus type 1 (hsv-1) in adult mice, but not significantly. the protection of mice against hsv-1 infection and the production of neutralizing antibodies were significantly enhanced by the administration of lc 9018 in combination with inactivated hsv-1 antigen. the optimal enhancement of resistance was seen in mice 14 days after the simultaneous administration of these substances. the resistance to h ... | 1986 | 3012292 |
| possible polyclonal b cell activation in mucocutaneous lymph node syndrome. | immunoserological studies on polyclonal b cell activation were carried out on 39 patients with mucocutaneous lymph node syndrome (mcls) and in age-matched healthy individuals. the incidence of anti-mite, p. acnes (kato) and eb virus antibodies, recently proposed as aetiological agents by some investigators, was increased in the patient group. serum immunoglobulin (ig) m level and igm-anti-dinitrophenyl (dnp) antibodies, which are considered to be parameters of polyclonal b cell activation, were ... | 1986 | 3015624 |
| relationship of success in classical immunotherapy to the relative immunorejective strength of the tumor. | six tumors of varying immunorejective strengths were used to compare the response of their isogenic hosts to standardized regimens of immunoprophylaxis and immunotherapy. the tumors were generated spontaneously or induced chemically [with 9,10-dimethyl-1,2-benzanthracene (cas: 57-97-6)], virally (with murine leukemia virus), or radiogenically (with strontium-90). the hosts were c57bl/6j or balb/cbyj mice. immunoprophylaxis and immunotherapy were performed with isogenic irradiated tumor cells, wi ... | 1986 | 3020300 |
| the role of superoxide anion and lysosomal enzymes in anti-listerial activity of elicited peritoneal macrophages. | the in vitro effect of superoxide anion and lysosomal enzyme activity on the killing of listeria monocytogenes egd (listeria) by peritoneal macrophages (pm) was investigated. generation of superoxide anion by pm stimulated with phorbol myristate acetate (pma) was significantly increased by intraperitoneal injection of lactobacillus casei yit 9018 (lc9018) or corynebacterium parvum (cp), but not by injection of peptone. however, superoxide anion generation by lc9018-elicited pm stimulated with li ... | 1986 | 3020680 |
| biological activity of pityrosporum. ii. antitumor and immune stimulating effect of pityrosporum in mice. | the antitumor activity of pityrosporum (p. orbiculare, p. ovale, p. pachydermatis, and pityrosporum sp.) on ehrlich ascites carcinomas (eacs) implanted into outbred icr mice was studied. pityrosporum significantly prolonged the survival of mice, regardless of the administration mode. in the case of p. orbiculare, the maximum survival time was 32.3 days on the mean and was obtained by injection ip of 1 mg (dry weight) p. orbiculare for 7 consecutive days following inoculation of the tumor cells. ... | 1986 | 3022057 |
| alveolar lymphocyte proliferation induced by propionibacterium acnes in sarcoidosis patients. | the proliferation of lymphocytes induced by propionibacterium acnes (p. acnes) was measured by the in vitro incorporation of 3h-thymidine. the mean response rate of alveolar lymphocytes obtained by bronchoalveolar lavage was 2.23 +/- 0.89 in nine untreated sarcoidosis patients, 0.85 +/- 0.17 in five sarcoidosis patients given corticosteroids and 0.78 +/- 0.29 in 11 controls. the proliferation was significantly enhanced in the untreated patients compared to both the treated patients (p less than ... | 1986 | 3024453 |
| the effect of kupffer cell stimulation or depression on the development of liver metastases in the rat. | tumour cells from a squamous carcinoma (approximately 2.5 x 10(5)) were injected intraportally into a syngeneic strain of rats to produce liver metastases 14 days later. kupffer cells were stimulated by corynebacterium parvum (7 mg or 1 mg i.v.) and zymosan (10 mg intraportally). kupffer cell activity was depressed by the administration of silica, gadolinium chloride or human red cells. the animals in each group were sacrificed at 14 days, the livers removed and the number of visible surface met ... | 1986 | 3024833 |
| [antibiotic susceptibility of propionibacterium acnes; changes in the last 15 years at the department of dermatology, kansai medical university]. | 1986 | 2951538 | |
| acne vulgaris in childhood. pathogenesis and management. | acne vulgaris is a common skin disorder. although it is most prevalent in the second decade of life, its beginnings are heralded by increased activity of the sebaceous glands and faulty follicular keratinization, which are already evident in mid to late childhood. the subsequent and increasing proliferation of the follicular anaerobic diphtheroid microflora contribute further as an important pathogenic factor in the generation of inflammatory lesions. treatments of acne, therefore, are aimed at ... | 1986 | 2941198 |
| [treatment of skin changes in acne using propionibacterium antigens in the form of an oral vaccine]. | 1986 | 2942740 | |
| qualitative and quantitative changes in cutaneous bacteria associated with systemic isotretinoin therapy for acne conglobata. | quantitative cultures in 40 patients treated with systemic isotretinoin demonstrated a significant reduction in the anaerobic diphtheroid, propionibacterium acnes within one month of therapy and a continued suppression during 5 months of treatment. this reduction persisted after discontinuation of isotretinoin therapy despite a return of sebum excretion to pretreatment levels. surface aerobic bacteria showed a significant reduction in the total number of organisms and significant qualitative cha ... | 1986 | 2943823 |
| rational therapy for acne vulgaris: an update on topical treatment. | acne vulgaris is a disorder of sebaceous follicles that usually begins at the time of the sharp increase in androgen production that occurs in adolescence. this disease is most prevalent among teenagers, but it does occur in patients in their twenties and thirties. three major areas of pathophysiology have been identified in acne: hyperkeratinization and obstruction of sebaceous follicles, resulting from abnormal desquamation of follicular epithelium; an androgen-stimulated increase in the produ ... | 1986 | 2945846 |
| the in vitro antimicrobial effect of azelaic acid. | various strains of cutaneous micro-organisms were tested in vitro for their survival rates in 0.5 mol/l (8.4% w/v) azelaic acid solution. all bacterial strains exhibited large reductions in viability (at least 40-fold) over a 24 h test period, but little response was noted with pityrosporum ovale. the bactericidal effect of azelaic acid was reduced considerably in the presence of nutrients. minimum inhibitory concentrations (mics) and minimum bactericidal (or fungicidal) concentrations (mbcs) we ... | 1986 | 2947607 |
| photodestruction of endogenous porphyrins in relation to cellular inactivation of propionibacterium acnes. | during growth of propionibacterium acnes on eagles medium protoporphyrin was accumulated inside the cells and coproporphyrin, both as a free base as metalcontaining, outside the cells. the photochemical processes in the endogenous porphyrins were studied by fluorescence spectroscopy during continuous irradiation of propionibacterium acnes in suspension. the irradiation caused initially an increase in the content of protoporphyrin in the cells in comparison to that which had been accumulated duri ... | 1986 | 2948330 |
| comparing 2.5%, 5%, and 10% benzoyl peroxide on inflammatory acne vulgaris. | a 2.5% formulation of benzoyl peroxide was compared with its vehicle, and with a 5% and a 10% proprietary benzoyl peroxide gel preparation in three double-blind studies involving 153 patients with mild to moderately severe acne vulgaris. the 2.5% benzoyl peroxide formulation was more effective than its vehicle and equivalent to the 5% and 10% concentrations in reducing the number of inflammatory lesions (papules and pustules). desquamation, erythema, and symptoms of burning with the 2.5% gel wer ... | 1986 | 2948929 |
| in vitro and in vivo evaluation of a-56268 (te-031), a new macrolide. | the in vitro and in vivo antibacterial activity of a-56268 (te-031), the 6-o-methyl derivative of erythromycin, was compared with those of erythromycin and other reference drugs. a-56268 had the same spectrum of antibacterial activity as erythromycin. a-56268 was generally 1 log2 dilution more potent or equal to erythromycin against all organisms except haemophilus influenzae and propionibacterium acnes, for which a-56268 was 1 log2 dilution and 3 log2 dilutions, respectively, less potent. the m ... | 1986 | 2949695 |
| suppression of murine nk activity induced by corynebacterium parvum: further characterization and abrogation of suppressor cells. | formalin-killed corynebacterium parvum (cp), given at a dose of 0.4-0.7 mg/mouse iv or ip, induced suppressor cells for nk activity in b6c3f1 mice. the suppressor cells belong to at least two different populations, plastic adherent and nonadherent, and were not depleted by antibodies specific for thy-1.2, iak, or nk-1.2 surface markers. administration of p-i:c, an interferon-inducer, to animals 18 h before the assay did not affect the suppressor activity. hypotonic shock treatment of splenocytes ... | 1986 | 2935247 |
| macrophage membrane proteins: possible role in the regulation of priming for enhanced respiratory burst activity. | brief exposure of macrophages to the proteolytic enzymes papain, elastase, or trypsin primed them for enhanced production of superoxide anion (o2-) in response to stimulation by phorbol myristate acetate (pma). priming by trypsin was achieved at 0 degree c, at which temperature trypsin functions as a protease but is not internalized, supporting the concept that protease priming depends on modification of the plasma membrane. analysis of external membrane proteins after radioiodination of intact ... | 1986 | 3026655 |
| macrophage activation in rat models of inflammation and arthritis: determination of markers of stages of activation. | disease-associated alterations in macrophage functions were assessed by investigating the stages of activation of peritoneal macrophages obtained from adjuvant-induced arthritic rats. the stages of activation were established by defining several functional parameters in macrophages obtained from normal, sterile-irritant injected and propionibacterium acnes injected animals. peritoneal macrophages taken from arthritic rats 17 days post adjuvant injection displayed parameters characteristic of act ... | 1986 | 3026656 |
| differences in tumor necrosis factor productive ability among rabbits. | 1986 | 3100847 | |
| intrapleural and intravenous corynebacterium parvum in patients with resected stage i and ii non-small cell carcinoma of the lung. the ludwig lung cancer study group. | a prospective randomized trial compared the administration of intrapleural plus intravenous corynebacterium parvum (c. parvum) versus placebo in patients with resected stage i and stage ii non-small cell bronchogenic carcinoma. treatment consisted of 7 mg c. parvum injected into the pleural space and 7 mg c. parvum intravenously once between days 6 and 12 postoperatively and 7 mg intravenously every 3rd month during the 1st year. intrapleural administration of 35 cc of saline served as the place ... | 1986 | 2876772 |
| protection of mice against intestinal amoebiasis with bcg, corynebacterium parvum and listeria monocytogenes. | treatment with corynebacterium parvum or bcg, or infection with live listeria monocytogenes was found to protect mice against subsequent infection with entamoeba histolytica. complete protection was obtained in mice treated with 10(7) (colony forming units) of bcg but not with 10(5). partial protection was achieved with 10(6) of bcg. these data provide evidence that non-specific immunity plays an important role in the host defense against amoebic infection. | 1986 | 2880331 |
| antimicrobial activity of various immunomodulators: independence from normal levels of circulating monocytes and natural killer cells. | the effects of 89sr treatment on the natural host resistance of cd-1 mice and the enhancement of resistance by immunomodulators to infection with listeria monocytogenes or herpes simplex virus type 2 (hsv-2) were determined. in the cd-1 mouse, single-dose treatment with 89sr caused a profound decrease in the number of circulating monocytes (mo), lymphocytes, and polymorphonuclear leukocytes (pmn) within 1 week. there was also marked functional impairment of the mo inflammatory response, as well ... | 1986 | 2416693 |
| arthropathic properties of cell wall polymers from normal flora bacteria. | peptidoglycan-polysaccharide (pg-ps) fragments were purified from cell walls of group d streptococci (streptococcus faecium, strains atcc 9790 and f-24) with a protocol which minimizes autolytic activity and tested for ability to induce arthritis in rats. pg-ps fragments from cell walls of other normal flora bacteria (peptostreptococcus productus, and propionibacterium acnes), group a streptococci, and pseudomurein-ps fragments from cell walls of methanobacterium formicicum, were similarly purif ... | 1986 | 3940996 |
| ability of oral bacteria to degrade fibronectin. | the fibronectin-degrading ability of 116, mainly oral, strains was assayed by using plasma-derived fibronectin adsorbed to a polystyrene surface. ability to degrade fibronectin was revealed in strains of bacteroides gingivalis, bacteroides intermedius, bacteroides loeschii, staphylococcus aureus, staphylococcus epidermidis, peptococcus prevotii, clostridium sporogenes, and propionibacterium acnes. the fibronectinolytic activity of subgingival bacteriological samples was found to be related to th ... | 1986 | 3943910 |
| the microbial flora of the continent cecal urinary reservoir, its stoma and the peristomal skin. | the bacteria occurring in reservoir urine, on the cutaneous stoma and on the abdominal skin were studied in 9 patients who had undergone urinary diversion via a continent cecal reservoir. aerobic and/or facultatively anaerobic bacteria were isolated persistently from reservoir urine in 3 patients but only occasionally in the remainder. these organisms were isolated in pure culture. anaerobic bacteria also were found, although infrequently and only in conjunction with facultative anaerobes. most ... | 1986 | 3944854 |
| an action spectrum for blue and near ultraviolet inactivation of propionibacterium acnes; with emphasis on a possible porphyrin photosensitization. | 1986 | 3952162 | |
| bacterial lipases and chronic blepharitis. | eyelids and conjunctivae of 36 normal individuals and 60 patients from six clinical groups of chronic blepharitis were cultured for aerobic and anaerobic bacteria. the most common species isolated were coagulase-negative staphylococci (c-ns) and propionibacterium acnes. all strains of these species, and all staphylococcus aureus strains isolated were tested for the ability to break down triglycerides, cholesterol esters, and fatty waxes. each strain was incubated independently with appropriate s ... | 1986 | 3957566 |
| origin and differentiation of natural killer cells. ii. functional and morphologic studies of purified nk-1.1+ cells. | cells bearing the nk-specific marker nk-1.1 were purified from mouse spleens by utilizing a monoclonal anti-nk-1.1 antibody and cell sorting. in normal adult mice, all of the splenic nk activity against yac-1 cells was found in the nk-1.1+ fraction, whereas nk-1.1- cells were depleted of nk activity. the nk activity of sorted nk-1.1+ cells was enriched 15- to 30-fold over unfractionated spleen cells. light and electron microscopic studies of purified nk-1.1+ cells showed a homogeneous population ... | 1986 | 3958492 |
| suppressive effects of 3-methylcholanthrene on the in vitro antitumor activity of naturally cytotoxic cells. | transient suppression of splenic natural killer (nk), natural cytotoxic (nc), and peritoneal macrophage cytotoxicity was observed following a single injection of 3-methylcholanthrene (3-mc) into c3h/hen mice. natural killer cell activity was depressed by 30-60% 4-6 d after injection of 1.0 mg 3-mc. levels of nk reactivity returned to normal 8 d post 3-mc injection, and no suppression of natural killing was seen when tested 6 wk after 3-mc treatment. 3-mc did not affect propionibacterium acnes au ... | 1986 | 3959116 |
| adjuvant and antitumour activities of synthetic lipid a analogues. | the biological activities of synthetic glycolipids, which were chemically synthesized and based on the structure of lipid a of the lipopolysaccharide (lps) from escherichia coli, were examined with special reference to their adjuvant activity on the induction of delayed-type hypersensitivity, activity on the induction of tumour necrotic factor (tnf) and tumour regressive activity on line 10 hepatoma in strain 2 guinea pigs. among them, a compound structurally corresponding to free e. coli lipid ... | 1986 | 3962449 |
| determination of protein in polysaccharide-antibody complexes. | we describe a simple and sensitive method for determining antibody protein complexed with polysaccharide using binding of amido-black to antigen-antibody complexes and bovine serum albumin as protein standard. the method, which is a modification of the method used for the determination of total nitrogen or the protein concentration in milk, has shown a consistent quantitative relationship with the lowry procedure and has been developed for its particular application to serological precipitates. | 1986 | 3963752 |
| randomized study of corynebacterium parvum adjuvant therapy following surgery for (stage ii) malignant melanoma. | one hundred and fifteen patients with histologically proven primary cutaneous melanoma were entered into a randomized prospective study following surgical removal of clinically obvious regional metastases. the study started in 1977 and was completed in june 1982. fifty-eight patients (10 with regional skin metastases and 48 with regional node metastases) were in the control group and 57 (15 regional skin, and 42 regional node metastases) received adjuvant c. parvum. other clinical features were ... | 1986 | 3512025 |
| effect of macrophage activation on phagocyte-plasmodium interaction. | we investigated the effect of both immune and normal sera on the binding of free plasmodium berghei by resident and activated macrophages. resident macrophages bound plasmodia to a greater extent than did activated macrophages, regardless of treatment. resident macrophages bound free plasmodia, predominantly trophozoites, in the presence of normal serum by a mechanism inhibited by n-acetylglucosamine and n-acetylmannosamine. macrophages activated through treatment with propionibacterium acnes (" ... | 1986 | 3512432 |
| lack of biological significance of in vitro brugia malayi microfilarial cytotoxicity mediated by propionibacterium acnes ("corynebacterium parvum")-and mycobacterium bovis bcg-activated macrophages. | the effect of nonspecific activation of host macrophages by propionibacterium acnes ("corynebacterium parvum") or mycobacterium bovis bcg on brugia malayi microfilariae was determined by in vitro and in vivo studies. intraperitoneal injection of c. parvum or bcg stimulated peritoneal exudate cells, which were toxic to microfilariae. microfilariae were equally susceptible to damage by c57bl/6j or balb/cj peritoneal exudate cells. furthermore, inhibitors of oxidative metabolism and arginine supple ... | 1986 | 3516877 |
| bcg, in contrast to c. parvum, does not induce increased sensitivity to the toxic effects of indomethacin in mice. | treatment of mice with killed corynebacterium parvum (also designated propionibacterium acnes, p. acnes) or bacille calmette guerin (bcg) leads to modification of several of the same host systems. however, bcg, in contrast to c. parvum, did not induce increased sensitivity to the toxic effects of indomethacin in balb/c or c57b1/6 mice. in addition, treatment of mice with bcg did not interfere with the induction of sensitivity by c. parvum. therefore c. parvum must uniquely induce changes in host ... | 1986 | 3519813 |
| therapy of stage iii (optimal) epithelial carcinoma of the ovary with melphalan or melphalan plus corynebacterium parvum (a gynecologic oncology group study). | a randomized prospective therapy trial in patients with stage iii optimal epithelial carcinoma of the ovary was accomplished by the gynecologic oncology group. therapy with melphalan or melphalan plus immuno-adjuvant, corynebacterium parvum (c. parvum), was utilized as adjuvant treatment following surgical therapy. one hundred eight-five patients were eligible for evaluation with 87 patients in the melphalan group and 98 patients in the melphalan plus c. parvum group. the comparison of the treat ... | 1986 | 3525343 |
| a sequential study of hepatic structural damage following the intravenous injection of corynebacterium parvum. | sequential histological and fine structural changes were studied in liver from 4.5 min to 21 days after a single intravenous injection of corynebacterium parvum in the rat. a previously unreported effect of the micro-organism, the formation of eosinophilic inclusion bodies within hepatocytes, was observed between 15 min and 24 h of injection. these structures were most common in periportal hepatocytes at 2 h. the structural, enzyme- and immunohistochemical features of these bodies suggest that t ... | 1986 | 3527581 |
| propionibacterium acnes cerebral botryomycosis. the role of plastic embedding in the diagnosis of grain-producing infections. | botryomycosis is a chronic infection in which bacterial colonies, or "grains," occur in purulent exudate associated with draining sinus tracts or abscess formation. this condition usually is caused by staphylococcus and streptococcus, but other organisms occasionally have been implicated. this report describes the first case of botryomycosis caused by propionibacterium acnes, a diphtheroid that has been rarely associated with opportunistic disease. in this case, plastic embedding allowed the obs ... | 1986 | 3535486 |
| role of reactive oxygen intermediates in the hepatotoxicity of endotoxin. | administration of endotoxin (2.5 micrograms/mouse, iv) to corynebacterium parvum-pretreated (14 days earlier, 1 mg/mouse, i.v.) mice caused a rapid (90 min) decrease in liver cytochrome p450-dependent drug metabolism and an elevation of serum transaminase. the time course of the priming effect of c. parvum suggested that macrophages might be responsible for this sensitization to endotoxin. the antioxidant n-acetylcysteine (500 mg/kg) effectively protected against this depression of liver drug me ... | 1986 | 3546193 |
| the bacterial flora of the nasal cavity in healthy young men. | the nasal cavity of 97 young healthy men (applicants for the pilot education in the finnish air force) was examined. bacterial culture demonstrated one or more species of aerobic bacteria in all 194 nasal cavities examined and anaerobic bacteria in 76.5%. in ten per cent of the cultures bacteria were detected after enrichment only. the most common aerobic bacteria were staphylococcus epidermidis (79%), diphtheroids (41%) and staphylococcus aureus (34%). haemophilus influenzae was found in 5% and ... | 1986 | 3547601 |
| infections after craniotomy: a retrospective study. | a retrospective study was performed to evaluate the rate of infection directly related to craniotomy. of 246 craniotomies performed in 1981, 234 could be evaluated. the overall incidence of infection was 8.1% (19 infections in 18 patients). the infection rate was 15.2% after insertion of a ventricular shunt (seven infections after 45 ventriculostomies). staphylococcus aureus, staphylococcus epidermidis and propionibacterium acnes were the most frequent isolated micro-organisms. we recommended a ... | 1986 | 3701096 |
| failure to boost the increased clearance of embolic tumor cells from the lung with dose scheduling: corynebacterium parvum studies. | initial suboptimal, optimal and supraoptimal doses of intraperitoneal corynebacterium parvum were followed by 'booster' doses injected intraperitoneally 5, 10 and 25 days later. mice were challenged intravenously 4-6 days after the booster doses with [125i]iurd-labeled b16 tumor cells and the extent of clearance of these cells from the lungs analyzed 4 h later. in a second experiment, mice were given booster doses of c. parvum on days 4, 7 and 10 and then challenged on day 14 with labeled b16 tu ... | 1986 | 3703464 |
| antitumor and immunologic effects of a pyridine-extracted fraction of propionibacterium acnes. | the antitumor and immunological effects of a pyridine extractable fraction of propionibacterium acnes were tested in a murine ovarian teratocarcinoma (mot) model. previous studies have demonstrated that tumor rejection in this model depends upon sequential activation of tumoricidal neutrophils (pmns) followed by cytostatic macrophages. the pyridine extract significantly prolonged the survival of mice challenged with 10(3) or 10(4) mot cells but had little impact on a 10(5) tumor inoculum. in viv ... | 1986 | 3708631 |
| cytolytic interactions between murine macrophages, tumor cells, and monoclonal antibodies: characterization of lytic conditions and requirements for effector activation. | because of recent successes in inducing the effective rejection of neoplasms in vivo by administration of monoclonal antibodies (mab), we analyzed lytic interactions in vitro that occur between macrophages and several combinations of tumor targets and mab that can lead to such successful immunotherapy. murine macrophages, interacting with mab of the igg1, igg2a, igg2b, and igg3 isotypes directed against sw-1116 carcinoma cells, destroyed the tumor targets efficiently over 24 to 48 hr in vitro. l ... | 1986 | 3711663 |
| [antitumor efficacy of activated macrophages against murine glioma cells]. | a crucial manifestation of malignant gliomas is the regrowth of already-invaded neoplastic cells after surgical intervention. one possible approach for inhibiting such tumor growth is to utilize the tumoricidal potential of macrophages. in order to investigate the clinical application of this concept, peritoneal exudate cells (pec) activated in vitro and in vivo by immunomodulating agents were tested for cytotoxic activity against murine glioma (203-glioma) cells. as immunomodulating agents, hea ... | 1986 | 3717955 |
| microbiologic analyses of nasal polyp tissue. | nasal polyps from 40 patients were cultured within 2 1/2 hours after surgical removal to determine whether microorganisms were present. the first 20 polyps were cultured for aerobic and anaerobic bacteria, viruses, fungi, mycoplasmas, and mycobacteria. of these 20 polyps, eight were sterile by all tests, one grew cryptococcus albidus, one grew sporobolomyces, one had large numbers of peptostreptococcus micros and propionibacterium acnes, greater than 10(6) colony-forming units per gram (cfu/gm), ... | 1986 | 3722630 |
| therapeutic effect of endogenous tumor necrosis factor on ascites meth a sarcoma. | the therapeutic effect of endogenous tumor necrosis factor (tnf) on meth a ascites fibrosarcoma in mice was investigated. serum and peritoneal fluid from tumor bearing mice treated with ok-432 and lps were cytotoxic to tumor cells in vitro. the peak of cytotoxicity in both the serum and peritoneal fluid was found in the fraction corresponding to a molecular weight of approximately 54,000-56,000 on hplc and the pi was found to be 4.9-5.1 by isoelectric focusing. these results are consistent with ... | 1986 | 3722836 |
| [studies on experimentally induced acute hepatic failure in mice: the lps-nonresponder mice]. | 1986 | 3723850 | |
| superiority of intralesional immunotherapy with corynebacterium parvum and allium sativum in control of murine transitional cell carcinoma. | immunotherapy with bacillus calmette-guerin (bcg), corynebacterium parvum (cp), keyhole limpet hemocyanin (klh) and an extract of allium sativum (as) was studied in a transitional cell carcinoma (mbt-2) in mice. comparison was made between intraperitoneal (ip) versus intralesional (il) administration of these agents. c3h/he mice were transplanted subcutaneously in the hind limb with 5 x 10(4) tumor cells. after transplantation, mice were randomized into groups to receive either ip or il treatmen ... | 1986 | 3735559 |
| natural killer cells in leukemogenesis. | in order to relate a reduced natural killer (nk) cell function to leukemogenesis, nk cells in the spleen and peritoneal exudate cells, with and without stimulation by corynebacterium parvum, were tested in mice of various strains after split dose irradiation and after leukemogenic treatment with butyl- and methylnitrosourea. the investigations included also mice submitted to non-leukemogenic irradiation (1 x 1.5 and 1 x 4.5 gy) and mice submitted to an additional treatment with hydrocortisone, w ... | 1986 | 3736113 |
| measurement of nadph oxidase activity in detergent lysates of human and mouse macrophage monolayers. | an assay to measure nadph oxidase activity in detergent lysates of macrophage monolayers is described. the addition of a reaction mixture containing appropriate concentrations of disrupting detergents, nadph as oxidase substrate and cytochrome c as electron acceptor, to macrophages monolayers permits the reliable detection of a superoxide dismutase-sensitive nadph-dependent cytochrome c reductive activity. this activity is strictly substrate dependent and nadh could not substitute for nadph. the ... | 1986 | 3760584 |
| inhibition of wound healing by corynebacterium parvum. | corynebacterium parvum (c. parvum), an immunostimulant, was examined for its effects on wound healing in mice. animals injected intraperitoneally with c. parvum, 1400 micrograms 48 hr prior to wounding had significantly decreased wound strength at 5, 7, 11, 14, and 21 days after wounding compared to saline-injected controls (p less than 0.05-p less than 0.001). mice injected with c. parvum at 48 or 2 hr before wounding, synchronous with wounding and 2 or 48 hr after wounding had significantly de ... | 1986 | 3762128 |
| propionibacterium acnes infection in neurosurgical patients. experience with high-dose penicillin therapy. | propionibacterium acnes is an underestimated but significant cause of cerebrospinal fluid (csf) infection after neurosurgical procedures and in the presence of prosthetic devices. the most effective therapy for such infections has not been defined. we report here our experience with the use of high-dose penicillin in the treatment of six patients with postoperative infection which was caused by p. acnes. all patients received 3-4 million units of penicillin by the intravenous route every four ho ... | 1986 | 3762478 |
| [immunotherapy with corynebacterium parvum in experimental influenza virus infections and mixed infections in mice]. | 1986 | 3763446 | |
| corynebacterium parvum followed by chemotherapy (actinomycin d and dtic) compared with chemotherapy alone for metastatic malignant melanoma. | seventy-nine patients with stage iii widely metastatic melanoma were prospectively randomised to a 'no treatment' control group who received on tumour progression dtic (250 mg/m2 i.v. daily x 5) and actinomycin d 1.5 mg/m2 on day 1. a total of six courses at 3-week intervals was given. chemotherapy was only given on progression of disease. the other group received initially corynebacterium parvum (2 mg/m2) every 3 weeks for a maximum of eight courses and then the same chemotherapy on evidence of ... | 1986 | 3770045 |
| immunobiological activities of synthetic lipid a analogs with low endotoxicity. | synthetic lipid a analogs, beta(1-6)glucosamine disaccharide 1,4'-bisphosphates, which possesses four tetradecanoyl groups at the 2- and 2'-amino, and 3- and 3'-hydroxyl groups (la-17-pp), and each two of the (r)-3-hydroxytetradecanoyl and tetradecanoyl groups at the 2- and 2'-amino and 3- and 3'-hydroxyl groups, respectively (la-18-pp), were far less endotoxic than synthetic (506, la-15-pp) and bacterial escherichia coli type lipid a's; neither compound showed any detectable lethal toxicity in ... | 1986 | 3781622 |
| [intrahepatic cholestasis induced by heat-killed propionibacterium acnes in the tuberculin-sensitized guinea pig]. | 1986 | 3784062 | |
| [studies on an experimentally induced acute hepatic failure in mice: difference between the hepatotoxic factor and tumor necrosis factor]. | 1986 | 3784063 | |
| [effect of free fatty acids on propionibacterium acnes and staphylococcus epidermidis]. | 1986 | 3795558 | |
| histamine production by propionibacterium acnes in batch and continuous culture. | histamine production by propionibacterium acnes was studied using batch and continuous culture. in batch culture, the culture ph and the production of histamine closely paralleled the pattern of growth, increasing as the growth increased. continuous culture studies using a chemostat and varying culture ph showed that highest levels of growth of p. acnes occurred at ph 6.0 and that two clear 'peaks' of histamine production were apparent at ph 4.5 and at ph 7.5. the levels measured at ph 7.5 were ... | 1986 | 3796303 |
| canine oral melanoma: comparison of surgery versus surgery plus corynebacterium parvum. | eighty-nine dogs with malignant oral melanoma were selected for study. all dogs were clinically staged and treated with either surgical excision alone or surgery plus c. parvum immunotherapy. there was no difference in survival time between the two treatment groups. however, in dogs with advanced disease (stages ii, iii) there was a statistical difference between surgery alone versus surgery plus c. parvum (p = 0.01). dogs with stage i disease (tumor less than 2 cm diameter) had a statistically ... | 1986 | 3801954 |
| pharmacological analysis of guinea-pig macrophage chemiluminescence responses to platelet activating factor and opsonized zymosan. | the luminol-dependent chemiluminescence (cl) response in vitro of guinea-pig c. parvum-activated peritoneal macrophages to platelet activating factor (paf) has been compared with that to opsonized zymosan (opz). the response to paf (5 x 10(-6) mol/l.) reached a peak within 1 min, that to opz (0.17 mg/ml) within 10-20 min. peak responses to both stimuli were dose-dependently inhibited in a similar manner by p-hydroxymercuribenzoate (10(-5) - 10(-3) mol/l), sodium benzoate (10(-5) - 10(-3) mol/l.) ... | 1986 | 3804536 |
| distribution of metronidazole susceptibility factors in obligate anaerobes. | the distribution of metronidazole susceptibility factors in clinically important bacteria was studied to determine why obligate anaerobes were susceptible to metronidazole and facultative ones were not. with obligate and facultative anaerobes, nitroreductase activity, metronidazole uptake, pyruvate:ferredoxin oxidoreductase activity and drug susceptibility were estimated. nitroreductase activity was distributed in the obligate anaerobes and some facultative ones such as streptococcus faecalis. p ... | 1986 | 3804881 |
| activated macrophage hybridomas secreting a cytotoxic factor. | stable activated macrophage hybridomas were generated by somatic cell fusion between propionibacterium acnes-induced peritoneal exudate cells and ns-1 myeloma cells. five cell lines were obtained and each was cloned by limiting dilution; 59 clones were obtained. the cells of 2 clones (mp4-4 and mp4-8) which adhered to the culture dishes were selected for further analysis. these hybridomas exhibited non-specific esterase and beta-galactosidase intracellularly, and asialo gm1, mac-1, ia antigens a ... | 1986 | 3805745 |
| local interferon induction by bacterial lipopolysaccharide in mice after pretreatment with corynebacterium parvum. | c57bl/6 mice were injected intraperitoneally (i.p.) with corynebacterium parvum and subsequently, after an interval of 7-10 days, i.p. with lipopolysaccharide (lps). the peritoneal wash-fluid was recovered at various times after injection of lps. marked interferon (ifn) titers were observed between 2 and 10 h after injection of lps, whereas no ifn was detected in mice injected with either c. parvum or lps alone. very low doses of lps (0.1 microgram/mouse) were sufficient to cause ifn production ... | 1986 | 3805784 |
| tumor-specific suppressor t-cells which inhibit the in vitro generation of cytolytic t-cells from immune and early tumor-bearing host spleens. | spleen cells from dba/2 mice, after immunization with syngeneic p815 mastocytoma cells and corynebacterium parvum, respond to p815 in vitro with a brisk, secondary-type generation of cytotoxic cells. this cytotoxicity is mediated by antigen-specific t-lymphocytes and correlates with resistance to in vivo challenge. this model confirms the observations of previous investigators made in semisyngeneic hosts using an in vivo transfer model. spleen cells from "early" tumor-bearing hosts (tbhs), 7-12 ... | 1986 | 2936451 |
| [proof of the effectiveness of a clotrimazole cream paste in acne vulgaris]. | the efficacy of clotrimazol cream paste containing a penetration enhancer in the treatment of acne vulgaris was objectified by investigating the sebum composition. following treatment over three and six weeks, the ratio of triglyceride to free fatty acid significantly increased, which indicated an effective reduction of the lipase activity of propionibacterium acnes within the sebaceous follicle. | 1986 | 2938349 |
| calcium-dependent and -independent tumoricidal activities of polymorphonuclear leukocytes induced by a linear beta-1,3-d-glucan and phorbol myristate acetate in mice. | some antitumor immunomodulators, such as a linear beta-1,3-d-glucan from alcaligenes faecalis var. myxogenes ifo 13140 (tak), induce potent tumoricidal activity of polymorphonuclear leukocytes (pmns). in the present study we investigated the role of calcium on the tumoricidal activity of pmns induced by immunomodulators, especially tak. the calcium chelator ethylene glycol bis(beta-aminoethyl ether)-n,n,n',n'-tetraacetic acid (egta) almost completely inhibited tak-induced pmn cytotoxicity and th ... | 1986 | 3079591 |
| enhancement of hematopoietic response of mice by subcutaneous administration of lactobacillus casei. | mice that had received heat-killed lactobacillus casei (lc 9018) subcutaneously (s.c.) showed enhanced resistance to systemic (i.e., intravenous) infection with listeria monocytogenes, but the antilisterial resistance of mice was less augmented by s.c. administration of propionibacterium acnes ("corynebacterium parvum"). though there was little change in the total number of splenic leukocytes after s.c. administration of lc 9018, the monocyte-macrophage ratio increased after treatment, reaching ... | 1986 | 3082755 |
| [effects of krestin (psk) on drug-metabolizing enzymes with special reference to the activation of ft-207]. | the effects of psk on hepatic drug-metabolizing enzymes were investigated using sarcoma 180-bearing and non-tumor-bearing icr mice. psk, an immunomodulator, has been commonly used in combination with tegafur for post-operative adjuvant chemotherapy. tegafur is a typical masked compound transformed into 5-fu by the hepatic drug-metabolizing enzyme p-450. it has been reported that immunostimulants such as bcg and anaerobic corynebacterium suppress the drug metabolism. psk and propionibacterium acn ... | 1986 | 3090941 |
| modification of the antitumor action of corynebacterium parvum by stress. | social grouping and isolation of mice, in the presence of an acute stressor, were found to differentially affect the antitumor action of the immunological adjuvant corynebacterium parvum. socially grouped dba/2j mice were injected intradermally with p815 mastocytoma ascites cells. half the mice had a threshold dose of c. parvum admixed with the p815 cells. half the mice in each of those conditions were given acute, inescapable electric footshock. in a second experiment, the stressed mice were so ... | 1986 | 3092254 |
| suppression of fibroblast proliferation by activated macrophages: involvement of h2o2 and a non-prostaglandin e product of the cyclooxygenase pathway. | macrophages are considered promoters of fibroblast proliferation; however, suppression by activated macrophages may outweigh this effect. activated murine peritoneal macrophages obtained by in vivo exposure to c. parvum or by in vitro lps-activation of thioglycollate-induced macrophages, were tested for their effect on normal syngeneic dermal fibroblasts. c. parvum-activated macrophages, but not resident peritoneal macrophages suppressed fibroblast proliferation. similarly, macrophages activated ... | 1986 | 3093089 |
| the role of anti-asialo gm1 antibody-sensitive cells in the implementation of tumor-specific t cell-mediated immunity in vivo. | the present study deals with the role of cells sensitive to anti-asialo gm1 antibody treatment in t cell-mediated tumor cell eradication in vivo. rabbit anti-asialo gm1 antiserum was injected into c3h/he mice. this treatment not only resulted in almost complete abrogation of natural killer (nk) cell activity but also produced a potent inhibiting effect on the generation of activated macrophage activity induced by inoculating propionibacterium acnes (p. acnes). such an immunodepressed state laste ... | 1986 | 3093429 |
| immunomodulation with killed propionibacterium acnes in guinea pigs simultaneously vaccinated with brucella abortus strain 19. | immunomodulation with killed propionibacterium acnes was attempted in guinea pigs simultaneously vaccinated with brucella abortus strain 19. two groups, each comprised of 9 guinea pigs, were injected by different routes (s.c. and or i.v.) with 1.4 mg of p. acnes and 5 x 10(8) cfu of b. abortus, s-19, while 3 other groups each received either p. acnes, b. abortus s-19, or saline (s.c.). the antibody titers to b. abortus measured at 6, 10 and 14 weeks after vaccination indicated no significant (p ... | 1986 | 3094237 |
| frequency distributions of periodontal attachment loss. clinical and microbiological features. | the present investigation attempted to determine if the pattern of past periodontal destruction could be concisely summarized, and related to other clinical and microbiological parameters. 61 subjects between the ages of 12 and 61 years with destructive periodontal disease were evaluated at 6 sites per tooth for redness, plaque, suppuration, bleeding on probing, pocket depth, and attachment level. the frequency distribution of baseline attachment level measurements was computed for each individu ... | 1986 | 3462210 |