Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [atrophy of the gastric mucosa and helicobacter pylori]. | the authors investigated the prevalence of helicobacter pylori (h. p.) in atrophic gastritis in the antrum and/or in the corpus of the stomach (groups i-iv), as compared with mucosae without atrophy. criteria for elimination were age under 50 years, a case-history of the use of antibiotics during the last 6 months and chronic ingestion of alcoholic beverages. group iv was formed by probands with pernicious anaemia who were divided into sub-group iva with atrophy of the corpus and sub-group ivb w ... | 1993 | 8212615 |
| role of serology in monitoring treatment for helicobacter pylori infection in elderly patients. | fifteen elderly patients with type b gastritis caused by helicobacter pylori infection were treated with triple therapy consisting of colloidal bismuth subcitrate, amoxycillin and metronidazole. all were followed up every 6 weeks for 3 months. after triple therapy, eradication of the infection was confirmed in 12 patients (85%) by histology and bacteriology. in this group, a significant reduction in igg antibody levels against h. pylori was detected (p < 0.001). in a control group of 15 patients ... | 1993 | 8213329 |
| a role for culture in diagnosis of helicobacter pylori-related gastric disease. | in this study, our objective was to determine the presence of helicobacter pylori and other rapid urease-positive (rup) organisms in gastric biopsies in 70 patients, 30 of whom had ulcers or erosions. a retrospective chart review was undertaken to correlate diagnostic tests (culture and direct urease) with results of endoscopic examination and the patient's clinical information. eleven of 70 (15.7%) patients' biopsies were positive by both culture and direct urease for h. pylori, seven (10%) pat ... | 1993 | 8213715 |
| identification and characterization of an atpase system of helicobacter pylori and the effect of proton pump inhibitors. | 1993 | 8213737 | |
| detection of antibodies to helicobacter pylori using oral fluid specimens. | 1993 | 8215083 | |
| nizatidine prevents peptic ulceration in high-risk patients taking nonsteroidal anti-inflammatory drugs. | nonsteroidal anti-inflammatory drug (nsaid) use is increasingly recognized as a major factor associated with peptic ulcer disease and complications. we undertook a multicenter, double-blind, placebo-controlled trial to evaluate efficacy and safety of nizatidine in preventing ulcer formation in patients with osteoarthritis who were taking nsaids. | 1993 | 8215749 |
| effects of indomethacin on intragastric ph and meal-stimulated serum gastrin secretion in rheumatoid arthritis patients. | the effects of oral indomethacin on intragastric ph and serum gastrin were investigated in rheumatoid arthritis patients. nine patients (1 male, 8 female) without a history of peptic ulcer disease and 6 patients with a history of peptic ulcer disease (5 male, 1 female) were studied. to obviate helicobacter pylori infection as a confounding factor, only patients with positive h. pylori serology were included. after a 5-day period of placebo treatment and after a 5-day period of indomethacin (50 m ... | 1993 | 8218753 |
| omeprazole versus famotidine in the healing and relapse of duodenal ulcer. | sixty patients with symptomatic duodenal ulcer were randomized to receive either omeprazole (20 mg each morning) or famotidine (40 mg at night time) for 2-4 weeks in a double-blind parallel group clinical trial. healing rates were higher with omeprazole in comparison with famotidine after 2 weeks (77% vs. 40%, p < 0.001) and 4 weeks (93% vs. 80%, p = 0.2) of treatment. assessment of daily diary cards completed by all patients revealed that omeprazole rapidly relieved ulcer-related day pain and n ... | 1993 | 8218758 |
| short report: treatment of helicobacter pylori-associated duodenal ulcer with omeprazole plus antibiotics. | omeprazole heals most duodenal ulcers after 4 weeks of treatment but relapse is common. eradication of helicobacter pylori is associated with reduced rate of ulcer relapse. this study investigates the effect of omeprazole with antibiotics in h. pylori-associated duodenal ulceration. forty-three patients with endoscopically proven duodenal ulcer and h. pylori entered this study. treatment consisted of 20 mg omeprazole daily (four weeks) and seven days (first week) treatment with 400 mg metronidaz ... | 1993 | 8218761 |
| antibiotic treatment of duodenal ulcers. | 1993 | 8219439 | |
| immunocytochemical quantitation of inflammatory cells associated with helicobacter pylori infection. | inflammatory cells in helicobacter pylori-associated gastritis (hag) were quantified. the results were compared with the gastric biopsy samples from patients with non-helicobacter pylori gastritis (non-hag). in order to detect immunocytochemically sensitive antigens, the biopsy samples were acetone-fixed at -20 degrees c and processed into glycol methacrylate at 4 degrees c. parallel routine biopsy samples were formalin-fixed and paraffin-embedded. a larger, more selective retrospective study wa ... | 1993 | 8219923 |
| helicobacter pylori, pepsinogen, and risk for gastric adenocarcinoma. | the objective of this project was to determine the association of helicobacter pylori infection and serum pepsinogen levels on subsequent risk for gastric adenocarcinoma. this nested case-control study was set in a large health maintenance organization. one hundred thirty-six cases of gastric adenocarcinoma and 136 matched controls without adenocarcinoma from a large cohort that had contributed serum in the 1960's were studied. the presence of igg against h. pylori had previously been determined ... | 1993 | 8220091 |
| six-month maintenance treatment of duodenal ulcer with sucralfate: influence on antral gastritis and helicobacter pylori antral colonization--a prospective uncontrolled study. | fifty-four patients (41 men, 13 women), aged 17 to 78 years (mean +/- sd, 48.13 +/- 13.5 years), with endoscopically confirmed healing of their duodenal ulcer after treatment with sucralfate (2 gm bid for 4 to 8 weeks) were recruited for this study. they were started on a 6-month maintenance treatment with sucralfate 1 gm bid. endoscopy was done at the end of the 6-month period or whenever there was any evidence of ulcer relapse. helicobacter pylori antral colonization (clo test) and antral gast ... | 1993 | 8221815 |
| [the nomenclature of helicobacter pylori]. | 1993 | 8222974 | |
| [diagnosis of helicobacter pylori infection by 13c-urea breath test]. | depending on the character for the helicobacter pylori (hp) to decompose the urea by its endogenous urease, we have investigated the possibility to diagnose hp infection by 13c-urea breath test in 55 cases. also, we compared the diagnostic results from 13c-urea breath test with those from culture, histology, and rapid urease test. the satisfied accuracy for the detection of hp infection with 13c-urea breath test was indicated. | 1993 | 8222981 |
| phospholipase activity of helicobacter pylori and its inhibition by bismuth salts. biochemical and biophysical studies. | in this study we measured phospholipase a (pla) and c (plc) activity of media filtrates and french press lysates of the gastritis-inducing bacteria helicobacter pylori. we report here that both h. pylori lysates and filtrates contain pla1, pla2, and c enzymes, which readily hydrolyze a radiolabeled dipalmitoylphosphatidylcholine (dppc) and phosphorylcholine substrates, respectively. the specific activity of both pla and c enzymes were greatest in the 6.5-7.0 and 8.4-8.8 ph ranges, respectively. ... | 1993 | 8223083 |
| serum pepsinogens as markers of response to therapy for helicobacter pylori gastritis. | we have investigated the effect of therapy for helicobacter pylori gastritis on serum concentrations of pepsinogen i and ii in 43 patients. in the 22 patients in whom therapy resulted in dramatic decrease in gastritis scores and in clearance of the bacteria, there was a highly significant (p = 0.0001) fall in mean serum pepsinogen ii from 13.3 +/- 0.8 to 7.9 +/- 0.7 micrograms/liter, and a less pronounced fall in pepsinogen i from 89.0 +/- 5.9 to 78.5 +/- 0.4 micrograms/liter (p = 0.01). these c ... | 1993 | 8223084 |
| gastrospirillum hominis in asymptomatic, healthy individuals. | gastrospirillum hominis is a spiral-shaped bacterium found in the stomach. it has been implicated as a possible cause of chronic gastritis. we report two cases of g. hominis colonization observed in a series of 175 healthy, asymptomatic volunteers investigated for helicobacter pylori. none of the volunteers had symptoms or a history of gastrointestinal disease. both carriers of g. hominis had histological signs of chronic, active antral gastritis. multiple tests for h. pylori were negative. the ... | 1993 | 8223085 |
| humoral immune response against helicobacter pylori as determined by immunoblot. | an immunoblot method has been evaluated to diagnose helicobacter pylori infection serologically by comparing 69 serum specimens from patients with a positive gram stain and/or culture result and a positive urease test on biopsy material, as well as 51 serum specimens from patients with at least 4 negative urease tests, and negative microscopy and culture results. sensitivity and specificity was found to be 100%. recognition of the cross-reacting flagellin (66 kda), flagellar sheath protein (51 k ... | 1993 | 8223405 |
| helicobacter pylori positivity. | 1993 | 8223793 | |
| na+,k(+)-atpase of gastric cells. a target of helicobacter pylori cytotoxic activity. | the present study shows a direct impairing action of a cytotoxin-producing helicobacter pylori strain on the na+,k(+)-atpase (evaluated as k(+)-dependent phosphatase activity) of human gastric epithelial cells in culture. the toxin itself is likely involved in this action which may also account for the cell edema found in vivo in helicobacter pylori-colonized stomach. | 1993 | 8224240 |
| helicobacter pylori-associated gastric ulcer mimicking a gastric malignancy. | 1993 | 8224716 | |
| correlation between vacuolating cytotoxin production by helicobacter pylori isolates in vitro and in vivo. | approximately 50 to 60% of helicobacter pylori isolates produce a vacuolating cytotoxin in vitro. to assess cytotoxin production in vivo, we sought to determine whether infection with a tox+ h. pylori strain is associated with the presence of serum antitoxin antibodies. h. pylori isolates and serum samples were obtained from 30 patients, and serum samples were obtained from 20 uninfected patients as controls. sera were tested by enzyme-linked immunosorbent assay for reactivity with the purified ... | 1993 | 8225576 |
| purification of helicobacter pylori superoxide dismutase and cloning and sequencing of the gene. | the superoxide dismutase (sod) of helicobacter pylori, a pathogenic bacterium which colonizes the gastric mucosa, evoking a marked inflammatory response, was purified and characterized, and the n-terminal amino acid sequence was determined. the enzyme consists of two identical subunits each with an apparent molecular weight of 24,000. analysis of the primary structure and inhibition studies revealed that h. pylori possesses a typical procaryotic iron-containing enzyme. no other isoenzymes could ... | 1993 | 8225605 |
| comparison of three methods for the determination of the sensitivity of helicobacter pylori to metronidazole. | a comparison of various methods for the determination of the sensitivity of helicobacter pylori to metronidazole was undertaken. the validity of the agar dilution, the disc diffusion and the epsilometer (e) test was studied using a total of 86 strains, 16 of which were known to be resistant to metronidazole. all tests were carried out on mueller-hinton agar with 5% sheep blood. the results of the disc diffusion and the e-test were highly significantly (p < 0.001) associated with those of the aga ... | 1993 | 8226415 |
| serum pepsinogen i and ii concentrations and igg antibody to helicobacter pylori in dyspeptic patients. | to investigate the association between histologically confirmed gastritis, carriage of helicobacter pylori and pepsinogen (pg) i and pg ii concentrations. | 1993 | 8227432 |
| prevalence of lymphoid follicles and aggregates in helicobacter pylori gastritis in antral and body mucosa. | to evaluate the prevalence of lymphoid follicles and aggregates in the antral and body mucosa in helicobacter pylori gastritis and to assess if there were correlations with ulcers in the duodenum, pylorus, or stomach, and with chronic antral erosions. | 1993 | 8227434 |
| prostaglandin e2 in gastric mucosa of children with helicobacter pylori gastritis: relation to thickness of mucus gel layer. | to evaluate the changes in mucus gel layer thickness and prostaglandin e2 (pge2) content caused by helicobacter pylori infection in the antral mucosa of children: to assess whether decreased mucus gel thickness is related to pge2 production. | 1993 | 8227435 |
| is gastric metaplasia essential for duodenal ulcer? | multiple biopsies were taken from the duodenum of 100 patients (46 active duodenal ulcer, 14 healed duodenal ulcer, 40 control subjects) to detect duodenitis, gastric metaplasia and helicobacter pylori (hp). histamine-induced congo-red staining of the duodenal bulb was performed in additional 25 cases of active duodenal ulcer to determine the presence of functioning parietal cells in the duodenum. the incidence of duodenitis was 45% in control subjects and 76.7% in patients with duodenal ulcer ( ... | 1993 | 8228080 |
| the problem of chronic nonspecific gastritis: classification today. | 1993 | 8228091 | |
| h. pylori in postcholecystectomy symptoms. | 1993 | 8228094 | |
| helicobacter pylori gastric infection and sideropenic refractory anemia. | 1993 | 8229554 | |
| comparison of commercially available clo test with the locally prepared test. | 1993 | 8230668 | |
| [compared antibacterial activity of a new fluoroquinolone, sparfloxacin (at 4140, rp 64206) and four other fluoroquinolones against 332 strains of enteropathogen bacteria]. | the in vitro bacteriostatic and bactericidal activity of five fluoroquinolones--sparfloxacin, ciprofloxacin, ofloxacin, lomefloxacin and pefloxacin--was tested against 332 strains of enteric pathogens belonging to the genera salmonella, shigella, escherichia, yersinia, vibrio, campylobacter and helicobacter. some of the strains were resistant to one or several antibiotics. each fluoroquinolone showed identical bacteriostatic activity against susceptible and resistant strains except of those resi ... | 1993 | 8233625 |
| [significance of helicobacter pylori infection in the pathogenesis and natural history of peptic ulcer]. | recent studies strongly suggest that helicobacter pylori might have a significant role in the pathogenesis and rate of recurrence of peptic duodenal ulcer. various factors, such as the existence of ulcerogenic strains of the bacteria and susceptible subjects, might explain the fact that not more than 10% of the patients infected with h pylori actually have duodenal ulcer. its association with gastric ulcer and gastric carcinoma is not well defined. | 1993 | 8235170 |
| [helicobacter pylori: clinical pictures of an infectious disease with pathogen persistence]. | it is the aim of this paper to provide survey of the very fast developing field of medical research on helicobacter pylori which includes as different branches as gastroenterology, pharmacology or microbiology. after examination of the several diseases, pathological mechanisms, the diagnostical techniques and the therapeutical regimens, the authors of this study favorize an early indication for eradication of helicobater pylori. since research on helicobacter pylori is divided into many fields, ... | 1993 | 8237024 |
| [the role of helicobacter pylori in development of ulcers]. | 1993 | 8237063 | |
| clarithromycin as monotherapy for eradication of helicobacter pylori: a randomized, double-blind trial. | current regimens to eradicate helicobacter pylori usually consist of metronidazole plus a bismuth compound, as well as a third agent such as tetracycline. such regimens are not ideal because organisms may be metronidazole-resistant, side-effects occur, and compliance is often poor. this randomized, double-blind study was designed to assess the ability of clarithromycin, a new macrolide antimicrobial, as monotherapy to eradicate h. pylori. thirty-seven healthy volunteers who were h. pylori positi ... | 1993 | 8237933 |
| minimum analysis requirements for the detection of helicobacter pylori infection by the 13c-urea breath test. | in an attempt to identify the minimum criteria for scoring the 13c-urea breath test, we examined test results from 96 healthy subjects, 270 duodenal ulcer patients undergoing treatment to eradicate helicobacter pylori, and 1000 consecutive breath tests analyzed in our laboratory. | 1993 | 8237934 |
| helicobacter pylori is a risk factor for hepatic encephalopathy in acute alcoholic hepatitis: the ammonia hypothesis revisited. the veterans administration cooperative study group no. 275. | to determine whether infection with helicobacter pylori is a risk factor for portosystemic encephalopathy in patients with acute, moderate or severe alcoholic hepatitis. | 1993 | 8237940 |
| acid inhibition and amoxicillin activity against helicobacter pylori. | 1993 | 8237959 | |
| combined intravenous and oral omeprazole/amoxicillin therapy in patients with helicobacter pylori-positive acute peptic ulcer bleeding. | 1993 | 8237963 | |
| a current view of gastric cancer in the us. | in the us, the remarkable decline in the incidence of gastric cancer during the mid-portion of this century has leveled off during the last two decades as an equally remarkable and poorly understood increase in the percentage of the generally more unfavorable cardia cancers has become apparent. the importance of h. pylori infection is being actively investigated and treatment to reduce the infection may offer a means of decreasing the disease, particularly in areas of high incidence. the potenti ... | 1993 | 8239771 |
| evaluation of rapid urease test for detection of helicobacter pylori in gastric biopsy specimens. | using 80 gastric biopsy specimens from patients with various gastroduodenal diseases, the isolation rate of h. pylori and urease activity of the biopsy specimens were examined. the sensitivity and specificity of the rapid urease test was 84.6% and 75.9%, respectively, for the cultivation of h. pylori. the mean number of h. pylori detected in urease-positive and negative biopsy specimens was 10(6.1 +/- 0.9) and 10(4.5 +/- 1.2) cfu/g specimens, respectively. | 1993 | 8243603 |
| non-steroidal anti-inflammatory drug-induced gastropathy: a comparative endoscopic and histopathological evaluation of the effects of tenoxicam and diclofenac. | a 4-week double-blind study compared the potential for 20 mg/day tenoxicam or 100 mg/day diclofenac sodium to induce gastropathy in 36 patients with joint disease and assessed the influence of gastric colonization by helicobacter pylori. endoscopic assessment at the end of 4 weeks indicated that the mucosa was normal in 79% of tenoxicam-treated patients and 59% of diclofenac-treated patients. only 5% of patients in the tenoxicam group developed severe gastroduodenitis (> 11 haemorrhages or erosi ... | 1993 | 8243794 |
| diagnostic value of serum pepsinogen c in patients with raised serum concentrations of pepsinogen a. | hypopepsinogenaemia a is often found in patients with gastric atrophy and gastric surgery. in these conditions serum pepsinogen c provides additional diagnostic information, especially when expressed as pepsinogen a:c ratio. hyperpepsinogenaemia a has been shown in patients with duodenal ulcer disease, zollinger-ellison syndrome, hypertrophic gastropathy, chronic renal failure, and during omeprazole treatment. as patients with hyperpepsinogenaemia a often overlap in symptoms, endoscopical findin ... | 1993 | 8244094 |
| systemic and mucosal humoral responses to helicobacter pylori in gastric cancer. | the systemic igg response to helicobacter pylori was examined in 70 patients with gastric cancer. h pylori igg antibodies were assayed by enzyme linked immunosorbent assay (elisa), and serological recognition of h pylori antigens was characterised by western blotting. a percentage of 78.5 were seropositive by elisa. two of five patients under age 50 were seronegative. positivity was unrelated to age, sex, tumour type, or site. ninety one per cent of elisa positive cancer patients recognised the ... | 1993 | 8244098 |
| acute perforated duodenal ulcer is not associated with helicobacter pylori infection. | most patients with chronic duodenal ulcer disease have helicobacter pylori infection and eradicating it considerably reduces the relapse rate. the prevalence of h pylori in 80 patients (mean age = 52 years, range 17-85) presenting with acute perforated duodenal ulcer was examined and compared with age and sex matched hospital control patients. h pylori state was assessed by serum anti-h pylori igg (helico-g kit, porton) using a titre of 18 or less as negative with a specificity of 89% and sensit ... | 1993 | 8244099 |
| helicobacter pylori: comparison of dna fingerprints provides evidence for intrafamilial infection. | although a high prevalence of antibodies to helicobacter pylori has been documented within families, culture and dna typing of strains from infected children and their parents has not been evaluated. this study aimed to analyse h pylori infection within family groups. endoscopy, gastric biopsy, and h pylori culture were performed on all eight parents of four children who presented with dyspepsia and who had a positive h pylori culture. all biopsy specimens were cultured on columbia based blood a ... | 1993 | 8244100 |
| serological diagnosis of helicobacter pylori. | 1993 | 8244124 | |
| ultrastructural patterns of helicobacter pylori. | ultrastructural morphology of the bacterial bodies was studied in 40 helicobacter pylori positive cases. two bacterial patterns were identified, which were associated with different modes of contact with the epithelial cells and possibly with different stages of the natural history of the infection. | 1993 | 8244133 |
| gastric metaplasia and helicobacter pylori infection. | duodenal and antral mucosal biopsy specimens were obtained from 139 patients with dyspeptic complaints to study the prevalence and extent of gastric metaplasia in the duodenal bulb in relation to helicobacter pylori (h pylori) infection and duodenal ulcer disease. on logistic regression, the presence and extent of gastric metaplasia was not significantly associated with h pylori infection. the prevalence of gastric metaplasia, however, was found to be higher in patients with current or past evid ... | 1993 | 8244134 |
| helicobacter pylori positive resistant duodenal ulcers. | 1993 | 8244159 | |
| helicobacter pylori positive resistant duodenal ulcers. | 1993 | 8244160 | |
| helicobacter pylori positive resistant duodenal ulcers. | 1993 | 8244161 | |
| [helicobacter pylori associated gastritis: a primary study of ammonia and urea in gastric juice and mucus in gastric mucosa]. | the mucosa of 46 patients with histological chronic gastritis were cultured for helicobacter pylori (hp) and the ammonia and urea in their gastric juice were also determined. the results showed the average ammonia concentration (1.22 +/- 0.23 mmol/l) in hp positive patients was higher than that of hp negative patients (0.72 +/- 0.25 mmol/l), (p < 0.05). but the average urea concentration (0.45 +/- 0.29 mmol/l) in hp positive patients was lower than that of hp negative patients (2.71 +/- 1.20 mmo ... | 1993 | 8244308 |
| helicobacter pylori infection in japanese patients with adenocarcinoma of the stomach. | to examine the association of helicobacter pylori infection with adenocarcinoma of the stomach in japanese patients, we studied 29 patients and 58 matched controls. ascertainment of h. pylori status was based on the presence of specific igg to h. pylori. for the entire group, an association of this infection with gastric adenocarcinoma was suggested but not statistically significant. for patients in a putatively high-risk subgroup (non-cardia tumors and age < or = 70 years), the association was ... | 1993 | 8244577 |
| direct dna amplification and restriction pattern analysis of helicobacter pylori in patients with duodenal ulcer and their families. | sera from 14 patients with duodenal ulcer and their families were tested for igg antibodies to helicobacter pylori. fourteen serologically negative patients and their families served as controls. index patients and their family members who were serologically positive were advised to undergo endoscopic biopsy. gastric biopsy tissues were subjected to haeiii restriction analysis of nested polymerase chain reaction products of the urease gene. by serology, 28 (49.0%) of 57 in index families and 11 ... | 1993 | 8245543 |
| diagnosis of helicobacter pylori infection in a developing country: comparison of two elisas and a seroprevalence study. | serology to detect antibodies to helicobacter pylori is not frequently used as a diagnostic tool in developing countries. when compared to a commercial elisa, an elisa constructed and validated in thailand had a higher sensitivity (98% vs. 85%), specificity (76% vs. 66%), and negative predictive value (97% vs. 76%) for the detection of h. pylori infection among 104 patients with dyspepsia evaluated by endoscopy. the positive predictive value was 88% for both tests. serum antibody levels fell sig ... | 1993 | 8245544 |
| [immunologic study of chronic gastritis]. | 1993 | 8245632 | |
| [new development on the study of etiological pathology of gastritis, peptic ulcer and stomach cancers in relationship to helicobacter pylori infection]. | 1993 | 8245642 | |
| determination of the optimal transport system for helicobacter pylori cultures. | a range of solid and liquid media was evaluated for the ability to maintain survival of helicobacter pylori strains under different conditions. chocolate agar slopes maintained survival of most strains for longer than 3 days, some strains surviving for up to 9 days, despite a decreased number of viable cells. temperature and atmosphere did not significantly influence the performance of these slopes. the bbl campy pouch system also achieved a considerable recovery rate of h. pylori after storage ... | 1993 | 8246249 |
| evaluation of the polymerase chain reaction for detecting the urease c gene of helicobacter pylori in gastric biopsy samples and dental plaque. | a polymerase chain reaction (pcr) assay with oligonucleotide primers homologous to a portion of the urease c gene of helicobacter pylori was evaluated for specificity with pure dna and biopsy material. the assay was used to test for the presence of the organism in dental plaque. the species specificity of detection was confirmed by ensuring that the primers did not amplify dna extracts from h. cinaedi, h. felis, h. fennelliae, h. mustelae and h. nemestrinae. sixty-two gastric biopsy samples coll ... | 1993 | 8246250 |
| [should helicobacter pylori infections be treated?]. | 1993 | 8247715 | |
| gastritis associated with gastrospirillum hominis in children. comparison with helicobacter pylori and review of the literature. | interest in possible microbiological causes of gastritis has significantly increased since the discovery of helicobacter pylori. recently a spiral bacterium named gastrospirillum hominis was described in association with chronic gastritis in adult patients. here, we present the finding of gastrospirillum hominis in the gastric biopsies of two children who underwent upper endoscopy for gastrointestinal symptoms. the frequency of gastrospirillum hominis (0.3%) in our pediatric population was simil ... | 1993 | 8248105 |
| an evaluation of factors affecting helicobacter pylori prevalence in tibetans exiled in india. | helicobacter pylori infection is found world-wide although the epidemiology of infection has not been well defined in many geographical areas. the aims of this study were to determine the prevalence of h. pylori infection and chronic gastritis and the demographic correlates of infection in a single racial group in southern india. the sample population was selected randomly from the male population register of a tibetan refugee settlement. demographic data and results of endoscopy with antral muc ... | 1993 | 8249063 |
| [incidence of helicobacter pylori infections in patients with duodenogastric reflux]. | the purpose of the work was a comparison of the incidence of helicobacter pylori (hp) infections in persons with dyspeptic symptoms of non-ulcer dyspepsia (nud) character in relation to the presence or absence of duodenogastric reflux (dgr). the study included 80 patients aged from 17 to 80 years, 21 males and 59 females. in all studied patients endoscopy of upper digestive tract segment was performed with biopsy specimen taking for microbiological investigations. from each patient two biopsy sp ... | 1993 | 8249413 |
| [gastric hypersecretion, helicobacter pylori, and duodenal ulcer]. | 1993 | 8249528 | |
| the upper gastrointestinal series at a crossroads. | radiologic examination of the upper gastrointestinal tract, or the upper gastrointestinal series, is at a crossroads. as we approach the 21st century, it is possible to envision two very different scenarios for the future of this examination. the gradual but steady decline in the number of upper gastrointestinal studies done during the past decade could continue or even accelerate until this technique is no longer used in diagnostic radiology. or, spurred by new concerns about cost and safety in ... | 1993 | 8249715 |
| acid secretion and serum gastrin in normal subjects and patients with duodenal ulcer: the role of helicobacter pylori. | to compare gastric secretory function in patients with duodenal ulcer and in healthy volunteers with and without helicobacter pylori infection. | 1993 | 8249971 |
| quarterly communicable disease review january to march 1993. from the phls communicable disease surveillance centre. | 1993 | 8251211 | |
| [helicobacter pylori infection and peptic ulcer]. | 1993 | 8253034 | |
| [helicobacter pylori infection and peptic ulcer]. | 1993 | 8253035 | |
| [follicular gastritis in adults. relations with helicobacter pylori, histological and endoscopic aspects]. | follicular gastritis (fg) is characterized by lymphoid follicle hyperplasia in the gastric mucosa. the aim of this prospective study was to determine the prevalence of fg in adults, their relation to helicobacter pylori infection, and their histological and endoscopic features. of 445 patients (379 men, 66 women), 36.4 years old (range: 18-86), fg was detected in 63 patients (14.2%). this was highly significantly associated with h. pylori infection: 49/138 infected patients (35.5%) versus 14/307 ... | 1993 | 8253308 |
| demonstration of a phospholipid-rich zone in the human gastric epithelium damaged by helicobacter pylori. | recently, a hydrophobic layer has been shown by the contact angle method in human gastric biopsy specimens. the aim of this study was to show the existence of a phospholipid-rich layer in the human gastric epithelium and to investigate the influence of helicobacter pylori on these structures. | 1993 | 8253346 |
| gastric ammonia has a potent ulcerogenic action on the rat stomach. | the pathophysiological mechanism by which helicobacter pylori induces mucosal injury has not been clarified. the aim of this study was to investigate the role of urea, urease, and ammonia in rat gastric mucosal lesions using an ex vivo chamber model. | 1993 | 8253347 |
| comparison of commercial diagnostic tests for helicobacter pylori antibodies. | a number of serological tests measuring the presence of helicobacter pylori-specific serum immunoglobulin g (igg) are now commercially available. the aim of this study was to evaluate the clinical accuracy of five commercial h. pylori antibody tests: gap-igg (biomerica), helptest (amrad, kew, victoria, australia), helico-g (porton cambridge), pyloriset (orion diagnostica), and roche (roche diagnostics). a total of 162 subjects presenting for routine upper endoscopy were studied. h. pylori was di ... | 1993 | 8253958 |
| isolation of helicobacter pylori from saliva. | helicobacter pylori was grown in low numbers from the saliva of one of nine patients who were positive for gastric h. pylori. the saliva-derived isolate from this patient was identical to the antral biopsy-derived isolate from the same patient and differed from isolates cultured from the antral biopsies of all other patients by soluble-protein electrophoresis, restriction endonuclease dna analysis, and southern blot hybridization. this is the first observation, to our knowledge, of the recovery ... | 1993 | 8253990 |
| gastric cancer and helicobacter pylori infection. | to identify differences in the prevalence of helicobacter pylori infection in different groups of patients with gastric cancer. | 1993 | 8254106 |
| transformation of helicobacter pylori by chromosomal metronidazole resistance and by a plasmid with a selectable chloramphenicol resistance marker. | most strains of helicobacter pylori are naturally competent for uptake of chromosomal dna. transformation frequencies for streptomycin resistance or rifampicin resistance markers ranged from 1 x 10(-4) to 1 x 10(-3) per viable cell using a plate transformation procedure. transformation of a metronidazole resistance marker (mtrr) was demonstrated when either a laboratory-derived mutant or a mtrr clinical isolate were used as the source of donor dna. mtrr was transformed at a frequency of 3 x 10(- ... | 1993 | 8254319 |
| helicobacter canis sp. nov., a new species from dogs: an integrated study of phenotype and genotype. | a group of campylobacter-like organisms (clos) were isolated from the faeces of diarrhoeic or healthy dogs, constituting 4% of all clos from this source. since they formed a unique dna homology group within the genus helicobacter, and exhibited distinctive phenotypic properties, they were collectively termed the hc group. a polyphasic taxonomic analysis was made of this group. the phenotype of four dog isolates and a single human isolate was unique and could be distinguished bacteriologically fr ... | 1993 | 8254320 |
| [cost and effectiveness of diagnosis and treatment of patients with dyspepsia as determined by computer model]. | 1993 | 8255326 | |
| use of endoscopic biopsies and microelectrodes to study human gastric acid secretion in vitro. | we have investigated the possibility of measuring acid secretion from human gastric mucosa in vitro as a potential pharmacological preparation. we used open-ended 10 microns-tip, lix-based glass microelectrodes to measure the ph of the mucus layer of gastric biopsies superfused with a hepes buffered solution in an organ bath. with no drugs added the ph of the mucus layer of biopsies from the body of the stomach stayed constant but the ph of antral biopsies fell slightly by a median of 0.12 ph un ... | 1993 | 8255402 |
| chronic gastritis, prostaglandins and helicobacter pylori. | 1993 | 8256482 | |
| [histological lesions and helicobacter pylori colonization in children]. | we have assessed the relationship between histologic findings and the helicobacter pylori (hp) colonization in 115 patients (age: 9.8 +/- 3.5 years) with hp infection. normal antral histology was found in 8.7% of the patients. signs of histological activity were observed in 58.2% of the patients and glandular lesions in 3.5%. a significantly greater hp colonization was observed in patients with signs of histological activity (p < 0.001). a significant correlation was found between the hp coloniz ... | 1993 | 8256947 |
| pepsinogens in health and disease. | pepsinogens, precursors of pepsins (potent and abundant digestive enzymes that are the primary products of the gastric chief cells), are members of the family of aspartic proteases. because of the heterogeneity of pepsinogens, several classifications have appeared in the literature. i describe the recommended classification and nomenclature of the aspartic proteases and discuss their genetics, biochemistry (structure, activation of zymogens, mechanism of proteolytic activity and inhibitors), and ... | 1993 | 8260073 |
| helicobacter pylori prevalence in a routine upper gastrointestinal endoscopy population. | the presence of helicobacter pylori (hp) in gastric biopsy specimens of 500 patients referred for routine upper gastrointestinal endoscopy for various abdominal complaints was investigated histologically and microbiologically. hp was detected in 429 of the 500 patients (86%). antral biopsy specimens revealed gastritis in 457 out of 500 cases (91.4%). in the 43 patients who had normal histological findings, only 3 had hp infection (7%). the prevalence of hp in the patients with gastric and duoden ... | 1993 | 8260335 |
| non-ulcer dyspepsia and gastritis--clinical aspects. | although patients with non-ulcer dyspepsia (nud) and peptic ulcer disease present similar symptoms, the two diseases are pathophysiologically completely different and should be treated accordingly. the diagnosis of nud is still based on negative criteria, i.e., organic diseases must be excluded. the majority of the patients with nud have a functional disorder possibly as a consequence of psychological stress which, by activating processes within the central nervous system, may evoke a sequence o ... | 1993 | 8260734 |
| intragastric distribution and gastric emptying of solids and liquids in functional dyspepsia. lack of influence of symptom subgroups and h. pylori-associated gastritis. | the relative contributions of altered gastric motor function and helicobacter pylori-associated active chronic gastritis to the pathogenesis of functional dyspepsia are controversial. we therefore evaluated scintigraphically the intragastric distribution and gastric emptying of a mixed solid-liquid meal in 75 patients with functional dyspepsia; patients were subdivided on the basis of both specific symptom clusters and the presence or absence of h. pylori gastritis. twenty-one (28%) patients dis ... | 1993 | 8261829 |
| different interdigestive antroduodenal motility patterns in chronic antral gastritis with and without helicobacter pylori infection. | fasting antroduodenal motor activity was studied in 15 dyspeptic patients with chronic superficial antral gastritis and helicobacter pylori infection (group a), 10 dyspeptic patients with chronic superficial antral gastritis without helicobacter pylori infection (group b), and eight healthy control subjects (group c) by manometric recording of phases of the interdigestive migrating motor complex (mmc) prolonged over 240 min. a significantly lower incidence of activity fronts (phase iii of mmc) s ... | 1993 | 8261830 |
| role of helicobacter pylori serology in evaluating treatment success. | duodenal ulcer recurrence and gastritis are reduced with successful helicobacter pylori treatment. serology is accurate in the diagnosis of h. pylori, but its value in determining eradication is unproved. to evaluate the usefulness of serology in monitoring treatment, we measured serial serum antibodies in three patient groups: eradication success (n = 57), eradication failure (n = 19), and untreated patients (n = 24). eradication was determined by warthin starry staining of antral biopsies and ... | 1993 | 8261831 |
| helicobacter pylori in gastroduodenal diseases: rapid identification by endoscopic brush cytology. | previous reports showed helicobacter pylori (h. pylori) in type b gastritis-affected stomachs. this study was carried out to compare h. pylori staining effectiveness on biopsy to brush cytology. tissue and brush parallel samples of gastric mucosa with abnormal or normal appearances were examined: 57.6% h. pylori-positive pieces from the antrum and 19.2% from the body were found, versus 65.3% and 25% h. pylori-positive brush smears, respectively. h. pylori resembling organisms were mainly related ... | 1993 | 8261849 |
| cell vacuolization induced by helicobacter pylori: inhibition by bafilomycins a1, b1, c1 and d. | all available bafilomycins (a1, b1, c1 and d) inhibit and revert macroscopic vacuolization induced by helicobacter pylori cell-free extracts. bafilomycin a1 displays the highest activity, followed by bafilomycin b1, c1 and d. the different potency of bafilomycins correlates with their ability to inhibit the vacuolar-type atpase (v-atpase) and to dissipate the membrane ph gradient of intracellular acidic organelles. these results suggest that bafilomycins should be considered as possible therapeu ... | 1993 | 8262366 |
| fumarate catabolism in helicobacter pylori. | the metabolism of fumarate by helicobacter pylori was investigated employing one- and two-dimensional 1h and 13c nuclear magnetic resonance spectroscopy. metabolically competent cells generated malate and succinate from fumarate as the sole substrate indicating the presence of fumarase and fumarate reductase activities in the bacterium. in incubations of fumarate with cell lysates accumulation of lactate, acetate, formate and alanine was observed after the initial production of malate and succin ... | 1993 | 8275020 |
| helicobacter-associated hepatitis of mice. | 1993 | 8277716 | |
| helicobacter pylori and peptic ulcer disease. | medical therapy for duodenal or gastric ulcer disease has traditionally involved gastric acid antisecretory therapy for 4 to 8 weeks to promote initial healing and indefinitely to prevent recurrences of ulcer. the discovery of helicobacter pylori in most patients with peptic ulcer disease has led to a change in this approach. therapy designed to eradicate h pylori may facilitate ulcer healing with acid antisecretory agents and, more important, may greatly reduce the incidence of ulcer recurrence ... | 1993 | 8279151 |
| is peptic ulcer disease an infectious disease? | 1993 | 8279173 | |
| non-cardia gastric adenocarcinoma and helicobacter pylori infection. | the seroprevalence of igg antibodies to helicobacter pylori (hp-ab) was studied in 47 patients (29m, 18f, mean age +/- sd: 62.44 +/- 12.63 years) with non-cardia gastric carcinoma using an enzyme-linked immunosorbent assay. controls were: a) 50 healthy people well-matched with the cancer patients; b) 50 patients with dyspepsia well matched with the cancer patients. hp-ab were detected in 72.3% of patients with gastric carcinoma, in 68% of healthy people and in 88% of dyspeptics. no significant a ... | 1993 | 8280897 |
| special issue. the microbiology of helicobacter pylori. assessment of recent experimental evidence on the pathophysiology, cancerogenic potential, immunity and chemotherapy of h. pylori infections. | 1993 | 8280929 | |
| adherence of haemagglutinating helicobacter pylori to five cell lines. | helicobacter pylori causes gastritis and is an important factor for the development of peptic ulcer disease in man. we used two different methods to examine the adhesion of nine h. pylori strains, with different haemagglutinating properties, to five cell lines, hela s3, hfi, vero, sw1222 and wehi cells. the adhesion studies were performed a) as bacterial adhesion to a monolayer of tissue culture cells, visualizing bacteria with fluorescein-isothiocyanate-labelled antibodies, b) as cell agglutina ... | 1993 | 8280930 |