Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| evaluation of the mycobactericidal effect of thio-functionalized carbohydrate derivatives. | sugars with heteroatoms other than oxygen have attained considerable importance in glycobiology and in drug design since they are often more stable in blood plasma due to their resistance to enzymes, such as glycosidases, phosphorylases and glycosyltransferases. the replacement of oxygen atoms in sugars with sulfur forms thio-sugars, which are potentially useful for the treatment of diabetes and some bacterial and viral infections. here, we evaluated the antibacterial activity of thio-functional ... | 2017 | 28509874 |
| microbiological pattern of diabetic foot infections at a tertiary care center in a developing country. | to determine the microbiological profile and antibiotic susceptibility patterns of organisms isolated from diabetic foot ulcers in a tertiary care hospital karachi, pakistan. | 2017 | 28507348 |
| polyelectrolyte complexes based on alginate/tanfloc: optimization, characterization and medical application. | hydrogels based on alginate and tanfloc (a cationic biopolymer obtained from natural condensed tannins) were successfully prepared. tanfloc (tn) presents high aqueous solubility at phs lower than 10; it contains substituted amino sites and molar weight of ca. 600,000gmol(-1). a factorial design (2(2)) was used to optimize the yield of alginate/tanfloc polyelectrolyte complexes (pecs). dialysis recovered the overplus of alginate (ag) no complexed with tn. these materials were characterized by the ... | 2017 | 28501603 |
| catechol-functional chitosan/silver nanoparticle composite as a highly effective antibacterial agent with species-specific mechanisms. | in this study, silver nanoparticles (ag nps) coated with catechol-conjugated chitosan (css) were prepared using green methods. interestingly, we uncovered that css-coated ag nps (css-ag nps) exhibited a higher toxicity against gram-negative escherichia coli (e. coli) bacteria than against gram-positive staphylococcus aureus (s. aureus) bacteria. the differences revealed that the css-ag nps killed gram bacteria with distinct, species-specific mechanisms. the aim of this study is to further invest ... | 2017 | 28500325 |
| antibacterial and wound healing properties of chitosan/poly(vinyl alcohol)/zinc oxide beads (cs/pva/zno). | treatment against bacterial infection is crucial for wound healing. development of cost-effective antibacterial agent with wound healing properties is still in high demand. in this study we aimed to design chitosan/poly(vinyl alcohol)/zinc oxide (cs/pva/zno) beads as novel antibacterial agent with wound healing properties. cs/pva/zno beads were synthesized, and characterized by using xrd, ftir, sem, and tem analysis. pure chitosan exhibits two peaks at 2θ=10 and 20 and the cs/pva polymer matrix ... | 2017 | 28499948 |
| quaternary ammonium salts substituted by 5-phenyl-1,3,4-oxadiazole-2-thiol as novel antibacterial agents with low cytotoxicity. | twenty-one novel 5-phenyl-1,3,4-oxadiazole-2-thiol (pot) substituted n-hydroxyethyl quaternary ammonium salts (6a-g, 7a-g, 8a-g) were prepared and characterized by ftir, nmr, and elemental analysis. compounds 6a, 6c, and 8a were confirmed by x-ray single-crystal diffraction. they display the unsurpassed antibacterial activity against staphylococcus aureus, α-h-tococcus, escherichia coli, p. aeruginosa, proteus vulgaris, canidia albicans, especially 6g, 7g, 8g with dodecyl group. compounds 8a-d w ... | 2017 | 28498641 |
| prevention, removal and inactivation of escherichia coli and staphylococcus aureus biofilms using selected monoterpenes of essential oils. | the aim of this study was to investigate the antibiofilm potential of five essential oils (eos) components with cyclic (sabinene-sab, carveol-c1, carvone-c2) and acyclic (citronellol-c3 and citronellal-c4) structures against escherichia coli and staphylococcus aureus. | 2017 | 28497526 |
| novel signal peptides improve the secretion of recombinant staphylococcus aureus alpha toxinh35l in escherichia coli. | secretion of heterologous proteins into escherichia coli cell culture medium offers significant advantages for downstream processing over production as inclusion bodies; including cost and time savings, and reduction of endotoxin. signal peptides play an important role in targeting proteins for translocation across the cytoplasmic membrane to the periplasmic space and release into culture medium during the secretion process. alpha toxinh35l (ath35l) was selected as an antigen for vaccine develop ... | 2017 | 28497288 |
| determining the possible etiology of hospital-acquired pneumonia using a clone library analysis in japan. | obtaining precise etiological information regarding causative bacteria is important for the proper use of antimicrobials in hospital-acquired pneumonia (hap), which is associated with a high rate of mortality. the aim of this study was to comparatively investigate the bacterial diversity in bronchoalveolar lavage fluid (balf) in japanese patients with hap by the clone library method using the 16s rrna gene. this study included japanese patients with hap who were treated at our hospital and refer ... | 2017 | 28496015 |
| live-cell nanoscopy in antiadhesion therapy. | live-cell nanoscopy has contributed significantly to assessing the inhibition of adhesion of uropathogenic escherichia coli and staphylococcus aureus by glycoconjugates and monoclonal antibodies, respectively, and of s. aureus surface attachment and cell-cell association by a synthetic peptide. this new technology shows promise for the development of antiadhesion therapies against bacterial pathogens. | 2017 | 28495024 |
| the effect of low-temperature laundering and detergents on the survival of escherichia coli and staphylococcus aureus on textiles used in healthcare uniforms. | to determine the survival of escherichia coli and staphylococcus aureus on cotton and polyester and the effectiveness of low-temperature laundering and detergents on the removal of micro-organism from healthcare laundry. | 2017 | 28489297 |
| filtration and electrochemical disinfection performance of pan/pani/agnws-cc composite nanofiber membrane. | the removal and inactivation of waterborne pathogens from drinking water are important for human health. here, a polyacrylonitrile/polyaniline/silver nanowires-carbon fiber cloth (pan/pani/agnws-cc) composite nanofiber membrane was fabricated using a simple and rapid coelectrospinning process, and an electrical device was applied with the pan/pani/agnws-cc filter for water electrochemical disinfection. the effects of voltage, flow rate, and microbial concentration on the filtration and electroch ... | 2017 | 28488855 |
| bacteriological trends and antibiotic susceptibility patterns of clinical isolates at government cancer hospital, marathwada. | preventing and starting early treatment of infections in patients whose immunity system is weak due to malignancies can reduce mortality. since our hospital is a newly constructed one, this study aimed to determine microbial and antibiotic resistance patterns in clinical samples of patients with cancer at our center to start early treatment before the results of clinical tests are known. | 2017 | 28485357 |
| synergic bactericidal effects of reduced graphene oxide and silver nanoparticles against gram-positive and gram-negative bacteria. | reduced graphene oxide (rgo) is a promising antibacterial material, the efficacy of which can be further enhanced by the addition of silver nanoparticles (nag). in this study, the mechanisms of antibacterial activity of rgo-nag nanocomposite against several important human pathogenic multi-drug resistant bacteria, namely gram-positive coccal staphylococcus aureus and gram-negative rod-shaped escherichia coli and proteus mirabilis are investigated. at the same concentration (100 µg/ml), rgo-nag n ... | 2017 | 28484209 |
| gepotidacin (gsk2140944) in vitro activity against gram-positive and gram-negative bacteria. | gepotidacin is a first-in-class, novel triazaacenaphthylene antibiotic that inhibits bacterial dna replication and has in vitro activity against susceptible and drug-resistant pathogens. reference in vitro methods were used to investigate the mics and minimum bactericidal concentrations (mbcs) of gepotidacin and comparator agents for staphylococcus aureus, streptococcus pneumoniae, and escherichia coli gepotidacin in vitro activity was also evaluated by using time-kill kinetics and broth microdi ... | 2017 | 28483959 |
| silver nanoparticle and lysozyme/tannic acid layer-by-layer assembly antimicrobial multilayer on magnetic nanoparticle by an eco-friendly route. | a facile, economical and green synthetic route was developed to fabricate magnetic nanocomposite arming with silver nanoparticles (agnps) for antibacterial application. in this synthesis, two natural compounds, positively charged lysozyme (lys) and negatively charged tannic acid (ta), were alternately deposited on fe3o4 nanoparticles (ionps) surface by layer-by-layer (lbl) self-assembly technique. and then agnps were embedded by an in situ reduction of ag(+) so as to achieve complementary antiba ... | 2017 | 28482604 |
| construction of n-halamine labeled silica/zinc oxide hybrid nanoparticles for enhancing antibacterial ability of ti implants. | the traditional antibiotic treatment for bacterial infections often induces antibiotic resistance in bacteria. in this work, we developed hybrid nanoparticles (nps) with a self-antibacterial ability on ti implants using monodispersed polystyrene-acrylic acid (psa) nanoparticles as colloidal templates followed by the electrostatic adsorption of zinc oxide (zno) and the subsequent deposition of silica (sio2) membrane on the outside. these synthesized psa-zno-sio2 nps were pretreated by 5,5-dimethy ... | 2017 | 28482556 |
| iodine-loaded metal organic framework as growth-triggered antimicrobial agent. | zeolitic imidazolate framework-8 (zif-8) is one of easily available metal organic frameworks because of its facile preparation via mixing aqueous solutions of zinc nitrate and 2-methylimidazole. it turned into a very effective ph-responsive bactericide after loading with iodine. approximately, 0.9g of iodine could be readily loaded into one gram of zif-8 from iodine dissolved n-heptane solution. both gram-negative escherichia coli and gram-positive staphylococcus epidermidis and staphylococcus a ... | 2017 | 28482553 |
| characterization of membranes based on cellulose acetate butyrate/poly(caprolactone)triol/doxycycline and their potential for guided bone regeneration application. | this paper discusses the feasibility of using membranes based on cellulose acetate butyrate/poly(caprolactone)triol loaded with doxycycline for guided bone regeneration. those membranes were obtained by solvent casting varying the cellulose acetate butyrate: poly(caprolactone)triol:doxycycline (cab:pcl-t:dox) mass ratios and characterized by scanning electron microscopy, differential scanning calorimetry, dynamical mechanical analysis, swelling and weight loss, drug release, in vitro antimicrobi ... | 2017 | 28482539 |
| poly(amino acid-hydroxyethyl methacrylate)s with chiral lysine and/or leucine side moieties and their antibacterial abilities for biomedical applications. | biomedical applications of the synthetic polymers with amino acid side moieties have been studied in light of their biocompatibility. in this work, poly(amino acid-hydroxyethyl methacrylate)s with lysine (lys)/leucine side moieties were synthesized via reversible addition-fragmentation chain transfer polymerization, and were verified with intrinsic chirality. for biomedical uses, their antibacterial abilities as well as hemolysis and cytotoxicity were investigated. the results indicated that the ... | 2017 | 28482475 |
| influence of ball milling on the particle size and antimicrobial properties of tridax procumbens leaf nanoparticles. | the herbal nanoparticles were prepared from shade dried tridax procumbens plant leaves employing ball milling technique using different process parameters, like ball ratio/size and milling time. the obtained nanoparticles were comprehensively characterised using x-ray diffraction, fourier transform infrared spectroscopy, uv-visible spectroscopy, dynamic light scattering, scanning electron microscopy and antimicrobial analysis techniques. the crystallinity of the nanoparticles was retained withou ... | 2017 | 28476955 |
| evaluation of sampling locations in pregnant women and newborns for the detection of colonisation with antibiotic-resistant bacteria. | up to now, little has been known about the prevalence and clinical relevance of colonisation of asymptomatic pregnant women with methicillin-susceptible staphylococcus aureus (mssa), methicillin-resistant s. aureus (mrsa) or extended-spectrum β-lactamase (esbl)-producing escherichia coli. in this two-centre cross-sectional study, we evaluated the performance and importance of screening at different times and different locations for colonisation in pregnant women and newborns. between october 201 ... | 2017 | 28474179 |
| examining the safety of menstrual cups among rural primary school girls in western kenya: observational studies nested in a randomised controlled feasibility study. | examine the safety of menstrual cups against sanitary pads and usual practice in kenyan schoolgirls. | 2017 | 28473520 |
| green synthesis and characterization of ag nanoparticles from mangifera indica leaves for dental restoration and antibacterial applications. | green synthesis has gained a wide recognition as clean synthesis technique in the recent years. in the present investigation, silver nanoparticles were prepared by a novel green synthesis technique using mangifera indica (mango leaves) and found to be successfully used in dental applications. the prepared samples were spectroscopically characterized by xrd, psa, sem with eds, and uv-vis spectroscopy. the crystalline size and lattice strain were analyzed from the xrd data which were counter-verif ... | 2017 | 28470622 |
| a polymerization-associated structural switch in ftsz that enables treadmilling of model filaments. | bacterial cell division in many organisms involves a constricting cytokinetic ring that is orchestrated by the tubulin-like protein ftsz. ftsz forms dynamic filaments close to the membrane at the site of division that have recently been shown to treadmill around the division ring, guiding septal wall synthesis. here, using x-ray crystallography of staphylococcus aureus ftsz (saftsz), we reveal how an ftsz can adopt two functionally distinct conformations, open and closed. the open form is found ... | 2017 | 28465423 |
| bright carbon dots as fluorescence sensing agents for bacteria and curcumin. | carbon dots (c-dots) are fluorescent nanomaterials that possess good photostability and low toxicity. they have been used as sensing probes and bioimaging agents for a variety of biological species. numerous methods are available to generate c-dots. nevertheless, simple and straightforward synthesis methods must be explored for the synthesis of c-dots from inexpensive, natural sources. in this study, we developed a simple method to generate c-dots from inexpensive chicken egg whites through a on ... | 2017 | 28463765 |
| steroid-au(i) -nhc complexes: synthesis and antibacterial activity. | a series of gold(i) pioneer complexes bearing n-heterocyclic carbenes and steroid derivatives (ethynylestradiol and ethisterone) with the generic formula [au(r2 -imidazol-2-ylidene)(steroid)] (where r=ch3 or ch2 ch2 och3 ) were synthesized, and the x-ray structure of a rare of gold(i)-estradiol derivative is discussed. toxicity studies reveal notable antibacterial activity of the gold-based compounds, which is significantly increased in vivo by the presence of the estradiol unit. toxicity profil ... | 2017 | 28463422 |
| sortase a-mediated crosslinked short-chain dehydrogenases/reductases as novel biocatalysts with improved thermostability and catalytic efficiency. | (s)-carbonyl reductase ii (scrii) from candida parapsilosis is a short-chain alcohol dehydrogenase/reductase. it catalyses the conversion of 2-hydroxyacetophenone to (s)-1-phenyl-1,2-ethanediol with low efficiency. sortase was reported as a molecular "stapler" for site-specific protein conjugation to strengthen or add protein functionality. here, we describe staphylococcus aureus sortase a-mediated crosslinking of scrii to produce stable catalysts for efficient biotransformation. via a native n- ... | 2017 | 28596548 |
| eco-friendly synthesis of silver nanoparticles using green algae (caulerpa serrulata): reaction optimization, catalytic and antibacterial activities. | stable colloidal silver nanoparticles (agnps) were synthesized using caulerpa serrulata (green marine algae) aqueous extract as an efficient reducing and stabilizing agent. this method is considered to be a sustainable alternate to the more complicated chemical procedures. to achieve the optimization synthesis of agnps, several effects such as extract concentration, contact time, ph values, and temperature were examined. the synthesized agnps were characterized by uv-vis spectroscopy, ft-ir, xrd ... | 2017 | 28646435 |
| healing potential of zerumbone ointment on experimental full-thickness excision cutaneous wounds in rat. | zerumbone is a monocyclic sesquiterpene compound. based on report, it is the predominant bioactive compound from the rhizomes of zingiber zerumbet. the study was undertaken to evaluate the therapeutic effects of topical zerumbone on excision wounds in rats. a 1% (w/w) simple ointment containing zerumbone was applied topically (100 mg ointment per rat) once a day on full-thickness excision wounds created on rats. the wound tissue was removed and used for estimation of antioxidant activity and to ... | 2017 | 28454680 |
| potassium iodide potentiates antimicrobial photodynamic inactivation mediated by rose bengal in in vitro and in vivo studies. | rose bengal (rb) is a halogenated xanthene dye that has been used to mediate antimicrobial photodynamic inactivation for several years. while rb is highly active against gram-positive bacteria, it is largely inactive in killing gram-negative bacteria. we have discovered that addition of the nontoxic salt potassium iodide (100 mm) potentiates green light (540-nm)-mediated killing by up to 6 extra logs with the gram-negative bacteria escherichia coli and pseudomonas aeruginosa, the gram-positive b ... | 2017 | 28438946 |
| synthesis, characterization, antimicrobial and antiproliferative activity evaluation of cu(ii), co(ii), zn(ii), ni(ii) and pt(ii) complexes with isoniazid-derived compound. | hydrazone complexes of cu(ii), co(ii), zn(ii), ni(ii) and pt(ii) with n-isonicotinoyl-n'-(3-metoxy-2 hydroxybenzaldehyde)-hydrazone (hl) were synthesized and characterized by different physico-chemical techniques including elemental and thermal analysis, magnetic susceptibility measurements, molar electric conductivity, as well as ir (infrared), ¹h-nmr and (13)c-nmr (hydrogen and carbon nuclear magnetic resonance, uv-vis (ultraviolet-visible), fab (fast atom bombardment), epr (electron paramagne ... | 2017 | 28422067 |
| zinc ion coordinated poly(ionic liquid) antimicrobial membranes for wound healing. | herein, a series of quaternary ammonium (qa) or imidazolium (im) cation-based poly(ionic liquid) (pil) membranes and their corresponding zinc ion coordinated pil membranes were synthesized. the effects of chemical structure, including organic cations, alkyl side chain of substitution, and zinc atoms on the antimicrobial activities against escherichia coli, staphylococcus aureus, and candida albicans were investigated. the zn-containing pil membranes show higher antibacterial activities compared ... | 2017 | 28418650 |
| tmcactin plays an important role in gram-negative and -positive bacterial infection by regulating expression of 7 amp genes in tenebrio molitor. | cactin was originally identified as an interactor of the drosophila iκb factor cactus and shown to play a role in controlling embryonic polarity and regulating the nf-κb signaling pathway. while subsequent studies have identified the roles for cactin in the mammalian immune response, the immune function of cactin in insects has not been described yet. here, we identified a cactin gene from the mealworm beetle, tenebrio molitor (tmcactin) and characterized its functional role in innate immunity. ... | 2017 | 28418029 |
| electrospun fiber pads of cellulose acetate and essential oils with antimicrobial activity. | the method of electrospinning was used to create nanofibers made of cellulose acetate (ca) and essential oils (eos). ca polymer at 15% w/v was dissolved in acetone and then 1% or 5% v/v of eos was added to the polymer solution. the utilized essential oils were rosemary and oregano oils. then, the ca/eos in acetone solution were electrospun, creating micro/nanofibers, approximately 700-1500 nm in diameter. raman spectroscopy was used to detect the attachment of the eos in the ca electrospun fiber ... | 2017 | 28417912 |
| the naturally occurring host defense peptide, ll-37, and its truncated mimetics ke-18 and kr-12 have selected biocidal and antibiofilm activities against candida albicans, staphylococcus aureus, and escherichia coli in vitro. | amongst the recognized classes of naturally occurring antimicrobials, human host defense peptides are an important group with an advantage (given their source) that they should be readily translatable to medicinal products. it is also plausible that truncated versions will display some of the biological activities of the parent peptide, with the benefit that they are less costly to synthesize using solid-phase chemistry. the host defense peptide, ll-37, and two truncated mimetics, ke-18 and kr-1 ... | 2017 | 28408902 |
| bovine mastitis prevention: humoral and cellular response of dairy cows inoculated with lactic acid bacteria at the dry-off period. | the use of lactic acid bacteria (lab) in animal feed, constitute an alternative tool for bovine mastitis prevention. previously, two lab strains were isolated from bovine milk and selected for their probiotics properties. so far, immune response of inoculating lab in bovine udders at dry-off period has not been investigated. the immunoglobulin isotype levels and memory cell proliferation in blood and milk of animals inoculated with lactobacillus lactis subsp. lactis crl1655 and lactobacillus per ... | 2017 | 28701082 |
| reduction in fecal microbiota diversity and short-chain fatty acid producers in methicillin-resistant staphylococcus aureus infected individuals as revealed by pacbio single molecule, real-time sequencing technology. | methicillin-resistant staphylococcus aureus (mrsa) may cause potentially lethal infections. increasing evidence suggests that the gut microbiota is associated with human health. yet, whether patients with mrsa infections carry specific signatures in their fecal microbiota composition has not been determined. thus, this study aimed to compare the fecal microbiota profile of mrsa-positive patients (n=15) with individuals without mrsa infection (n=15) by using the pacbio single molecule, real-time ... | 2017 | 28455781 |
| labradorins with antibacterial activity produced by pseudomonas sp. | the urgent need for new antibacterial drugs has led to renewed interest in microorganisms, which historically have been the main source of previously discovered antibiotics. the present study describes the discovery of two new antibacterial oxazolylindole type alkaloids, labradorins 5 (1) and 6 (2), which were isolated and characterized from two isolates of pseudomonas sp., along with four previously known tryptophane derived alkaloids. the structures of 1 and 2 were determined by nmr spectrosco ... | 2017 | 28654009 |
| palivizumab prophylaxis in infants with cystic fibrosis does not delay first isolation of pseudomonas aeruginosa or staphylococcus aureus. | respiratory syncytial virus (rsv) infections may worsen cystic fibrosis (cf) lung disease and favor pseudomonas aeruginosa (pa) or staphylococcus aureus (sa) acquisition, which is of particular importance in the youngest patients. we aimed to determine the effectiveness of pvz on microbiological outcomes in young children with cf. we conducted a retrospective case-control study to compare these outcomes in children who systematically received pvz (pvz+; n = 40) or not (pvz-; n = 140). one case w ... | 2017 | 28508992 |
| next generation sequencing-based multigene panel for high throughput detection of food-borne pathogens. | contamination of food by chemicals or pathogenic bacteria may cause particular illnesses that are linked to food consumption, commonly referred to as foodborne diseases. bacteria are present in/on various foods products, such as fruits, vegetables and ready-to-eat products. bacteria that cause foodborne diseases are known as foodborne pathogens (fbps). accurate detection methods that are able to reveal the presence of fbps in food matrices are in constant demand, in order to ensure safe foods wi ... | 2017 | 28578266 |
| sensitivity to antibiotics of bacteria exposed to gamma radiation emitted from hot soils of the high background radiation areas of ramsar, northern iran. | over the past several years our laboratories have investigated different aspects of the challenging issue of the alterations in bacterial susceptibility to antibiotics induced by physical stresses. | 2017 | 28432369 |
| dynamics of mono- and dual-species biofilm formation and interactions between staphylococcus aureus and gram-negative bacteria. | microorganisms are not commonly found in the planktonic state but predominantly form dual- and multispecies biofilms in almost all natural environments. bacteria in multispecies biofilms cooperate, compete or have neutral interactions according to the involved species. here, the development of mono- and dual-species biofilms formed by staphylococcus aureus and other foodborne pathogens such as salmonella enterica subsp. enterica serovar enteritidis, potentially pathogenic raoultella planticola a ... | 2017 | 28401747 |
| seven new lignan glycosides from the branches of alangium kurzii craib var. laxifolium. | seven new lignan glycosides (1-3, 8-10, and 14) and 17 known compounds were isolated from the branches of alangium kurzii craib var. laxifolium. their structures were established by spectroscopic analysis and circular dichroism (cd) and x-ray analysis. the isolated compounds were evaluated for their antibacterial activities against staphylococcus aureus ci1011, streptococcus suis ci1608, salmonella gallinarum ci0912, enterococcus faecalis ci1304, aeromonas hydrophila ci1008, escherichia coli ci1 ... | 2017 | 28733150 |
| antibacterial effects of lactobacillus isolates of curd and human milk origin against food-borne and human pathogens. | this study was undertaken to assess the antibacterial efficacy of lactobacilli isolated from curd and human milk samples. identities of thirty-one different lactobacilli (20 from curd and 11 from human milk) were confirmed by genus-specific pcr and 16s rrna-based sequencing. these strains belonged to five species, lactobacillus casei, l. delbrueckii, l. fermentum, l. plantarum, and l. pentosus. antibacterial activities of cell-free supernatants (cfss) of all the lactobacillus isolates were estim ... | 2017 | 28401466 |
| deep ssi after mesh-mediated groin hernia repair: management and outcome in an emergency surgery department. | mesh-mediated groin hernia repair is considered the goldstandard procedure. it has low recurrence rate. rarely a deep surgical site infection (ssi) is seen when a synthetic prosthesis is used. | 2017 | 28460203 |
| topical application of josamycin inhibits development of atopic dermatitis-like skin lesions in nc/nga mice. | patients with atopic dermatitis (ad) have superficial skin colonization by staphylococcus aureus and an increased number of t helper type 2 (th2) cells in their peripheral blood. our previous study showed that josamycin, a macrolide antibiotic, had excellent bactericidal activity against s. aureus strains isolated from ad patients and simultaneously inhibited th1 and th2 cell development mediated by langerhans cells. the purpose of the present study was to evaluate the effect of topical applicat ... | 2017 | 28459659 |
| lethal and sublethal effect of a dielectric barrier discharge atmospheric cold plasma on staphylococcus aureus. | the lethal and sublethal effect of a dielectric barrier discharge atmospheric cold plasma on staphylococcus aureus were investigated by nonselective and selective media. the inactivation level and sublethally injured proportions of s. aureus cells by dielectric barrier discharge atmospheric cold plasma depended on the treatment times (0, 5, 15, and 45 s), applied input powers (40, 50, and 60 w), and gap distances (2, 4, and 6 mm). under weak conditions (e.g., 5 s, 40 w, and 6 mm), the occurrence ... | 2017 | 28459615 |
| prevalence of inducible clindamycin resistance in methicillin-resistant staphylococcus aureus: the first study in jordan. | a high rate of infections with methicillin-resistant staphylococcus aureus (mrsa) has been documented, in both hospital- (ha-mrsa) and community-acquired (ca-mrsa) diseases in jordan. erythromycin and clindamycin are considered treatments of choice. however, resistance to erythromycin with false susceptibility to clindamycin in vitro may lead to therapeutic failure. hence, it is mandatory to study the prevalence of inducible resistance to macrolide-lincosamide-streptogramin b (imlsb) antibiotics ... | 2017 | 28459227 |
| inflammatory responses and histopathological changes in a mouse model of staphylococcus aureus-induced bloodstream infections. | staphylococcus aureus-induced bloodstream infections (bsis) remain a prevalent clinical challenge and the underlying pathogenesis is still poorly understood. the aim of this study was to investigate the inflammatory responses and histopathological changes in bsis in mice. | 2017 | 28459220 |
| genomic analysis of vancomycin-resistant staphylococcus aureus vrs3b and its comparison with other vrsa isolates. | high-level vancomycin resistance among staphylococcus aureus poses a grave threat to global health as the treatment options for this pathogen are very limited. a detailed evaluation of the genetic background of vancomycin-resistant s. aureus (vrsa) is expected to facilitate the understanding of its origin and pathogenicity. in this study, we performed the genetic analysis of the clinical vrsa isolates and identified the genetic basis of resistance to multiple antibiotics among these strains, bas ... | 2017 | 28458299 |
| effectiveness of a computer-facilitated, pharmacist-driven antimicrobial stewardship program for infection management. | in recent years, hospitals have routinely implemented antimicrobial stewardship (as) programs, and it is important that these programs are effective. consequently, we utilized a customized computer system to support infection management and implemented a pharmacist-driven as program in our hospital. using this computer system, a pharmacist monitored the daily usage of carbapenems and agents against anti-methicillin-resistant staphylococcus aureus and generated a patient database. with the use of ... | 2017 | 28458296 |
| the usefulness of silkworms as a model animal for evaluating the effectiveness of medicine and food. | development of novel medicines is an important responsibility of researchers in the field of pharmaceutical sciences. however, the discovery of new therapeutically effective without side effects is not an easy job. i think the limiting step of drug discovery is the process of evaluating the therapeutic effects of candidate drugs. to overcome this problem, i would like to propose a novel approach, "drug discovery with silkworms". | 2017 | 28458287 |
| recombinant pbp2a as a vaccine candidate against methicillin-resistant staphylococcus aureus: immunogenicity and protectivity. | methicillin-resistant staphylococcus aureus infections are focal and development of an effective vaccine can help to control this infection. here, recombinant pbp2a was studied in mouse model. following the preparation of recombinant pbp2a, balb/c mice were injected subcutaneously with 20 μg of r-pbp2a formulated in freund's adjuvant three times with three weeks intervals with proper control group. total and specific isotype antibodies were evaluated on sera by elisa. opsonophagocytic activity w ... | 2017 | 28457901 |
| molecular characterization and antibiotic resistance of staphylococcus spp. isolated from cheese processing plants. | the aim of this research paper was to characterize coagulase-positive and coagulase-negative staphylococci from raw milk, minas cheese, and production lines of minas cheese processing. one hundred isolates from 3 different cheese producers were characterized using molecular approaches, such as pcr, molecular typing, and dna sequencing. staphylococcus aureus (88% of the isolates) was the most abundant followed by staphylococcus epidermidis, staphylococcus hyicus, and staphylococcus warneri. among ... | 2017 | 28457548 |
| outpatient treatment of osteomyelitis with telavancin. | telavancin is a lipoglycopeptide antibiotic with bactericidal activity against gram-positive pathogens including staphylococcus aureus, the most frequent cause of osteomyelitis. treatment is often challenging due to needs for surgical intervention along with prolonged administration of intravenous antimicrobials, frequently in an outpatient setting. this was a retrospective analysis of the efficacy and safety of telavancin for treatment of osteomyelitis provided as outpatient parenteral antimicr ... | 2017 | 28456704 |
| identification of the key interactions in structural transition pathway of ftsz from staphylococcus aureus. | the tubulin-homolog protein ftsz is essential for bacterial cell division. ftsz polymerizes to form protofilaments that assemble into a contractile ring-shaped structure in the presence of gtp. recent studies showed that ftsz treadmilling coupled with the gtpase activity drives cell wall synthesis and bacterial cell division. the treadmilling caused by assembly and disassembly of ftsz links to a conformational change of the monomer from a tense (t) to a relaxed (r) state, but considerable contro ... | 2017 | 28456664 |
| staphylococcus aureus promotes smed-pgrp-2/smed-setd8-1 methyltransferase signalling in planarian neoblasts to sensitize anti-bacterial gene responses during re-infection. | little is known about how organisms exposed to recurrent infections adapt their innate immune responses. here, we report that planarians display a form of instructed immunity to primo-infection by staphylococcus aureus that consists of a transient state of heightened resistance to re-infection that persists for approximately 30days after primo-infection. we established the involvement of stem cell-like neoblasts in this instructed immunity using the complementary approaches of rna-interference-m ... | 2017 | 28456423 |
| structure and function of the two-component cytotoxins of staphylococcus aureus - learnings for designing novel therapeutics. | staphylococcus aureus can produce up to five different bi-component cytotoxins: two gamma-hemolysins hlgab and hlgcb, and leukocidins sf-pv (panton valentine leukocidin), ed (luked) and gh (lukgh, also called lukab). their major function in s. aureus pathogenesis is to evade innate immunity by attacking phagocytic cells and to support bacterial growth by lysing red blood cells. the five cytotoxins display different levels of amino acid sequence conservation (30-82%), but all form a remarkably si ... | 2017 | 28455832 |
| identification of causative organism in cardiac implantable electronic device infections. | the causative organism in cardiovascular implantable electronic device (cied) infection is usually diagnosed with the cultures from blood, removed leads, and/or infected pocket material. the cultured organism, however, is sometimes different among these samples. | 2017 | 28454777 |
| association of hospital contact precaution policies with emergency department admission time. | contact precautions are a widely accepted strategy to reduce in-hospital transmission of meticillin-resistant staphylococcus aureus (mrsa) and vancomycin-resistant enterococci (vre). however, these practices may have unintended deleterious effects on patients. | 2017 | 28454768 |
| synthesis of octapeptin c4 and biological profiling against ndm-1 and polymyxin-resistant bacteria. | the first synthesis of octapeptin c4 was achieved using a combination of solid phase synthesis and off-resin cyclisation. octapeptin c4 displayed antibiotic activity against multi-drug resistant, ndm-1 and polymyxin-resistant gram-negative bacteria, with moderate activity against staphylococcus aureus. the linear analogue of octapeptin c4 was also prepared, which showed reduced activity. | 2017 | 28454673 |
| patterns and predictors of antimicrobial resistance among staphylococcus spp. from canine clinical cases presented at a veterinary academic hospital in south africa. | antimicrobial resistance in staphylococci, often associated with treatment failure, is increasingly reported in veterinary medicine. the aim of this study was to investigate patterns and predictors of antimicrobial resistance among staphylococcus spp. isolates from canine samples submitted to the bacteriology laboratory at the university of pretoria academic veterinary hospital between 2007 and 2012. retrospective data of 334 staphylococcus isolates were used to calculate the proportion of sampl ... | 2017 | 28454567 |
| molecular imaging of activated platelets via antibody-targeted ultra-small iron oxide nanoparticles displaying unique dual mri contrast. | magnetic resonance imaging (mri) is a powerful and indispensable tool in medical research, clinical diagnosis, and patient care due to its high spatial resolution and non-limited penetration depth. the simultaneous use of positive and negative mri imaging that employs the same contrast agents will significantly improve detection accuracy. here we report the development of functional multimodal iron oxide nanoparticles for targeted mri of atherothrombosis using a combination of chemical and biolo ... | 2017 | 28453956 |
| eradication of staphylococcus aureus biofilm infections using synthetic antimicrobial peptides. | here, we demonstrate that antimicrobial peptides (amps) are an effective antibiofilm treatment when applied as catheter lock solutions (clss) against s. aureus biofilm infections. the activity of synthetic amps (bac8c, hb43, p18, omiganan, wmr, ranalexin, and polyphemusin) was measured against early and mature biofilms produced by methicillin-resistant s. aureus and methicillin-susceptible s. aureus isolates from patients with device-related infections grown under in vivo-relevant biofilm condit ... | 2017 | 28453851 |
| downstream element determines rnase y cleavage of the saepqrs operon in staphylococcus aureus. | in gram-positive bacteria, rnase j1, rnase j2 and rnase y are thought to be major contributors to mrna degradation and maturation. in staphylococcus aureus, rnase y activity is restricted to regulating the mrna decay of only certain transcripts. here the saepqrs operon was used as a model to analyze rnase y specificity in living cells. a rnase y cleavage site is located in an intergenic region between saep and saeq. this cleavage resulted in rapid degradation of the upstream fragment and stabili ... | 2017 | 28453818 |
| anti-microbial coating innovations to prevent infectious diseases (amici): cost action ca15114. | worldwide, millions of patients are affected annually by healthcare-associated infection (hcai), impacting up to 80,000 patients in european hospitals on any given day. this represents not only public health risk, but also an economic burden. complementing routine hand hygiene practices, cleaning and disinfection, antimicrobial coatings hold promise based, in essence, on the application of materials and chemicals with persistent bactericidal or -static properties onto surfaces or in textiles use ... | 2017 | 28453429 |
| infective endocarditis in principal hospital of dakar: a retrospective study of 42 cases over 10 years. | infective endocarditis (ie) is an endocardial infection usually caused by bacteria that affects not only the native heart valves but also, with increasing frequency intravascular implanted devices and congenital heart diseases. despite medical advances, ie remains a life-threatening disease with substantial morbidity and mortality. in africa, its diagnosis and treatment are still a major challenge in clinical practice. the objective of this work was to study the epidemiological, clinical feature ... | 2017 | 28451018 |
| are antibiotic-resistant pathogens more common in subsequent episodes of diabetic foot infection? | after antibiotic therapy of an initial diabetic foot infection (dfi), pathogens isolated from subsequent episodes might become more resistant to commonly prescribed antibiotics. if so, this might require a modification of the current recommendations for the selection of empiric antibiotic therapy. this study investigated whether the infectious diseases society of america (idsa) dfi guideline recommendations should be modified based on the number of past dfi episodes. | 2017 | 28450198 |
| evaluation of the eazyplex mrsa assay for the rapid detection of staphylococcus aureus in pleural and synovial fluid. | loop-mediated isothermal amplification (lamp) is a simple and sensitive technique for rapid microbiological diagnosis. the aim of this study was to evaluate the analytical and diagnostic performance of the lamp eazyplex mrsa test for the direct detection and differentiation of methicillin-susceptible (mssa) and methicillin-resistant staphylococcus aureus (mrsa) in synovial/pleural fluid. | 2017 | 28450195 |
| effects of surfactants on the formation of gelatin nanofibres for controlled release of curcumin. | this work studied the effects of non-ionic tween 80, anionic sodium dodecyl sulfonate (sds) and cationic cetyltrimethyl ammonium bromide (ctab) surfactants on the morphology of electrospun gelatin nanofibres, and on the release behaviour, antioxidant activity and antimicrobial activity of encapsulated curcumin. scanning electron micrographs showed that addition of sds significantly increased the nanofibre diameter. fourier transform infrared and differential scanning calorimetry analysis indicat ... | 2017 | 28450025 |
| relationship between vancomycin exposure and outcomes among patients with mrsa bloodstream infections with vancomycin etest® mic values of 1.5mg/l: a pilot study. | data suggest that vancomycin is less effective for methicillin-resistant staphylococcus aureus (mrsa) bloodstream infection (bsi) with vancomycin etest® mic (micetest) ≥1.5 mg/l. no published studies have evaluated the relationship between vancomycin exposure and outcomes among patients with mrsa bsis vancomycin micetest ≥1.5 mg/l. this study was a retrospective cohort of 71 hospitalized, adult, non-dialysis patients with mrsa bsis treated with vancomycin. all but three patients had a vancomycin ... | 2017 | 28449844 |
| noninferiority trial investigating the efficacy of a nonantibiotic intramammary therapy in the treatment of mild-to-moderate clinical mastitis in dairy cows with longer lasting udder diseases. | a nonblinded, positively controlled, noninferiority trial was conducted to evaluate the efficacy of an alternative, nonantibiotic therapy with masti veyxym(®) to reduce ineffective antibiotic usage in the treatment of nonsevere clinical mastitis (cm) in cows with longer lasting udder diseases. the solely intramammary treatment with masti veyxym(®) (three applications, 12 hr apart) and the combined treatment with masti veyxym(®) and antibiotics as usual on the farm according to label of the respe ... | 2017 | 28449183 |
| in response to: "ranjan, p, joshi p, and gupta m. staphylococcus aureus induced endogenous endophthalmitis with pink hypopyon." | 2017 | 28448724 | |
| future research opportunities in peri-prosthetic joint infection prevention. | peri-prosthetic joint infection (pji) is a serious complication of prosthetic joint arthroplasty. a better understanding and reversal of modifiable risk factors may lead to a reduction in the incidence of incisional (superficial and deep) and organ/space (e.g., pji) surgical site infections (ssi). recently, the centers for disease control and prevention (cdc) and the healthcare infection control practices advisory committee (hicpac) published the guideline for prevention of surgical site infecti ... | 2017 | 28448204 |
| a tandem liquid chromatography-mass spectrometry-based approach for metabolite analysis of staphylococcus aureus. | in an effort to thwart bacterial pathogens, hosts often limit the availability of nutrients at the site of infection. this limitation can alter the abundances of key metabolites to which regulatory factors respond, adjusting cellular metabolism. in recent years, a number of proteins and rna have emerged as important regulators of virulence gene expression. for example, the cody protein responds to levels of branched-chain amino acids and gtp and is widely conserved in low g+c gram-positive bacte ... | 2017 | 28448019 |
| staphylococcus aureus nasal carriage among medical students. | 2017 | 28447948 | |
| nanoemulsion is an effective antimicrobial for methicillin-resistant staphylococcus aureus in infected wounds. | to develop nb-201, a nanoemulsion compound, as a novel microbicidal agent against methicillin-resistant staphylococcus aureus (mrsa) infection, which is a common threat to public health but with limited therapeutic options. | 2017 | 28447896 |
| population dynamics of staphylococcus aureus in cystic fibrosis patients to determine transmission events by use of whole-genome sequencing. | strict infection control practices have been implemented for health care visits by cystic fibrosis (cf) patients in an attempt to prevent transmission of important pathogens. this study used whole-genome sequencing (wgs) to determine strain relatedness and assess population dynamics of staphylococcus aureus isolates from a cohort of cf patients as assessed by strain relatedness. a total of 311 s. aureus isolates were collected from respiratory cultures of 115 cf patients during a 22-month study ... | 2017 | 28446577 |
| risk factors for persistent methicillin-resistant staphylococcus aureus infection in cystic fibrosis. | methicillin-resistant staphylococcus aureus (mrsa) has emerged as an important pathogen in cystic fibrosis (cf). over 25% of individuals in the united states with cf are found to have mrsa in respiratory culture specimens, and persistent mrsa infection has been associated with more rapid decline in lung function and increased mortality. the objective of this study was to investigate clinical and demographic characteristics that are associated with the development of persistent mrsa infection in ... | 2017 | 28446387 |
| staphylococcus aureus pore-forming toxins: the interface of pathogen and host complexity. | staphylococcus aureus is a prominent human pathogen capable of infecting a variety of host species and tissue sites. this versatility stems from the pathogen's ability to secrete diverse host-damaging virulence factors. among these factors, the s. aureus pore-forming toxins (pfts) α-toxin and the bicomponent leukocidins, have garnered much attention for their ability to lyse cells at low concentrations and modulate disease severity. although many of these toxins were discovered nearly a century ... | 2017 | 28445785 |
| rapid detection of staphylococcus aureus and methicillin-resistant s. aureus in atopic dermatitis by using the bd max staphsr assay. | eczematous lesions of atopic dermatitis (ad) patients are known to be a source of staphylococcus aureus (sa) transmission and might be a reservoir for community-associated methicillin-resistant sa (mrsa). the bd max staphsr (bd-sr) is a fully automated, multiplex real-time pcr assay for the direct detection and differentiation of sa and mrsa from nasal swab samples. we evaluated the detection rates of sa and mrsa from skin lesions of outpatients with ad using the bd-sr assay, and determined the ... | 2017 | 28445011 |
| density assessment and mapping of microorganisms around a biocomposting plant in sanandaj, iran. | exposure to microorganisms can cause various diseases or exacerbate the excitatory responses, inflammation, dry cough and shortness of breath, reduced lung function, chronic obstructive pulmonary disease, and allergic response or allergic immune. the aim of the present study was to investigate the density of microorganisms around the air of processing facilities of a biocomposting plant. each experiment was carried out according to astm e884-82 (2001) method. the samples were collected from inha ... | 2017 | 28444609 |
| whole-genome sequencing of seven strains of staphylococcus lugdunensis allows identification of mobile genetic elements. | coagulase negative staphylococci are normal inhabitant of the human skin flora that account for an increasing number of infections, particularly hospital-acquired infections. staphylococcus lugdunensis has emerged as a most virulent species causing various infections with clinical characteristics close to what clinicians usually observe with staphylococcus aureus and both bacteria share more than 70% of their genome. virulence of s. aureus relies on a large repertoire of virulence factors, many ... | 2017 | 28444231 |
| maternal colonization with staphylococcus aureus and group b streptococcus is associated with colonization in newborns. | although staphylococcus aureus and group b streptococcus (gbs) are major causes of neonatal sepsis in sub-saharan africa, it is unclear how these bacteria are transmitted to the neonate. | 2017 | 28478240 |
| post-operative mrsa infections in head and neck surgery. | surgical site infection (ssi) with methicillin-resistant staphylococcus aureus (mrsa) is a serious post-operative complication, with head and neck cancer patients at greater risk due to the nature of their disease. infection with mrsa has been shown to be costly and impart worse outcomes on patients who are affected. this study investigates incidence and risks for mrsa ssis at a tertiary medical institution. | 2017 | 28478091 |
| pathogen-related factors affecting outcome of catheter-related bacteremia due to methicillin-susceptible staphylococcus aureus in a spanish multicenter study. | even with appropriate clinical management, complicated methicillin-susceptible staphylococcus aureus (mssa) catheter-related bacteremia (crb) is frequent. we investigated the influence of molecular characteristics of mssa strains on the risk of complicated bacteremia (cb) in mssa-crb. a multicenter prospective study was conducted in spain between 2011 and 2014 on mssa-crb. optimized protocol-guided clinical management was required. cb included endocarditis, septic thrombophlebitis, persistent ba ... | 2017 | 28477236 |
| down-regulation of the two-component system and cell-wall biosynthesis-related genes was associated with the reversion to daptomycin susceptibility in daptomycin non-susceptible methicillin-resistant staphylococcus aureus. | daptomycin (dap) is widely used in the treatment of methicillin-resistant staphylococcus aureus (mrsa) infection. the emergence of dap non-susceptible mrsa strains during therapy is a major concern in clinical settings. recent studies revealed that mrsa spontaneously reverts to a subsequent methicillin-susceptible s. aureus (mssa) strain. however, it is not clear whether dap non-susceptible mrsa has the ability to revert to a susceptible strain. we obtained an mrsa strain pair, dap non-susceptib ... | 2017 | 28477235 |
| infection with enterotoxigenic staphylococcus aureus as a concern in patients with gastroenteritis. | intestinal overgrowth of staphylococcus aureus may promote unpleasant disorders in the human intestinal tract. this study assessed the prevalence of enterotoxigenic multidrug-resistant s. aureus (mdr-sa) in patients with gastroenteritis. | 2017 | 28476559 |
| electrochemical advanced oxidation processes for staphylococcus aureus disinfection in municipal wwtp effluents. | this paper presents the staphylococcus aureus inactivation in a simulated wastewater treatment plant effluent by different electrochemical techniques, including the photo-electro-fenton process. s. aureus, dissolved organic carbon (doc), total oxidants and h2o2 concentrations, as well as ph, were monitored during the assays. an electrolytic cell, including a uva lamp, a gas diffusion electrode (gde) as cathode and an iro2 anode, was used to conduct the experiments under galvanostatic conditions ... | 2017 | 28475964 |
| infection prevention strategy in hospitals in the era of community-associated methicillin-resistant staphylococcus aureus in the asia-pacific region: a review. | community-associated methicillin-resistant staphylococcus aureus (ca-mrsa) has emerged as an important cause of healthcare-associated infection. ca-mrsa clones have replaced classic hospital mrsa clones in many countries and have shown higher potential in transmission and virulence than hospital mrsa clones. in particular, the emergence of ca-mrsa in the asia-pacific region is concerning owing to insufficient infection control measures in the region. the old strategies for infection prevention a ... | 2017 | 28475795 |
| mrsa transmission dynamics among interconnected acute, intermediate-term, and long-term healthcare facilities in singapore. | methicillin-resistant staphylococcus aureus (mrsa) is the most common healthcare-associated multidrug-resistant organism. despite the interconnectedness between acute care hospitals (achs) and intermediate- and long-term care facilities (iltcfs), the transmission dynamics of mrsa between healthcare settings is not well understood. | 2017 | 28475785 |
| sak and sak4 recombinases are required for bacteriophage replication in staphylococcus aureus. | dna-single strand annealing proteins (ssaps) are recombinases frequently encoded in the genome of many bacteriophages. as ssaps can promote homologous recombination among dna substrates with an important degree of divergence, these enzymes are involved both in dna repair and in the generation of phage mosaicisms. here, analysing sak and sak4 as representatives of two different families of ssaps present in phages infecting the clinically relevant bacterium staphylococcus aureus, we demonstrate fo ... | 2017 | 28475766 |
| signatures of cytoplasmic proteins in the exoproteome distinguish community- and hospital-associated methicillin-resistant staphylococcus aureus usa300 lineages. | methicillin-resistant staphylococcus aureus (mrsa) is the common name for a heterogeneous group of highly drug-resistant staphylococci. two major mrsa classes are distinguished based on epidemiology, namely community-associated (ca) and hospital-associated (ha) mrsa. notably, the distinction of ca- and ha-mrsa based on molecular traits remains difficult due to the high genomic plasticity of s. aureus. here we sought to pinpoint global distinguishing features of ca- and ha-mrsa through a comparat ... | 2017 | 28475476 |
| rhodomyrtus tomentosa leaf extract inhibits methicillin-resistant staphylococcus aureus adhesion, invasion, and intracellular survival in human hacat keratinocytes. | methicillin-resistant staphylococcus aureus (mrsa) has an ability to invade nonprofessional phagocytic cells, resulting in persistent infections and most likely host cell death. series of our studies have claimed pronounced antibacterial efficacy of rhodomyrtus tomentosa leaf extract. this study was to further investigate potency of the extract in intracellular killing of human hacat keratinocytes. pretreatment of mrsa with the extract resulted in a remarkable reduction in the bacterial adhesion ... | 2017 | 28475464 |
| the effect of negative pressure wound therapy with antibacterial dressings or antiseptics on an in vitro wound model. | the aim of this study was to investigate the bacterial bioburden in experimental in vitro wounds during the application of conventional negative pressure wound therapy (npwt), with and without antimicrobial dressings (polyhexanide, silver), against npwt instillation of octenidine. | 2017 | 28475440 |
| two new kaurane-type diterpenoids from wedelia chinensis (osbeck.) merr. | two new kaurane-type diterpenoids, 3α-(angeloyloxy)-17-hydroxy-ent-kaur-15-en-19-oic acid (1) and 3α-(tigloyloxy)-17-hydroxy-ent-kaur-15-en-19-oic acid (2), along with 10 known compounds (3-12) were isolated from the whole plant of wedelia chinensis (osbeck.) merr. their structures were elucidated on the basis of extensive spectroscopic analyses (uv, ir, ms and nmr) and comparison with literature data. compounds 3 and 4 showed moderate inhibitory activity against the staphylococcus aureus subsp. ... | 2017 | 28475376 |
| in situ forming and h2o2-releasing hydrogels for treatment of drug-resistant bacterial infections. | various types of commercialized wound dressings (e.g., films, foams, gels, and nanofiber meshes) have been clinically used as a physical barrier against bacterial invasion and as wound-healing materials. although these dressings can protect the wounded tissue from the external environment, they cannot treat the wounds that are already infected with bacteria. herein, we report in situ h2o2-releasing hydrogels as an active wound dressing with antibacterial properties for treatment of drug-resistan ... | 2017 | 28474514 |
| accuracy of complement activation product levels to detect infected pleural effusion in rats. | pleural empyema is a well-known complication of pneumonia. if treatment is delayed, empyema may increase morbidity and mortality in affected patients. therefore, the identification of empyema biomarkers in parapneumonic pleural effusion is desirable. previous research has suggested complement activation products as candidate empyema markers. | 2017 | 28474458 |
| a potential role for staphylococcal and streptococcal superantigens in driving skewing of tcr vβ subsets in tonsillar hyperplasia. | the tcr vβ repertoire from patients with recurrent tonsillitis and/or tonsillar hyperplasia was examined to determine whether the tcr vβ composition is suggestive of local superantigen activity and if so, whether it is associated with the presence of superantigen producing bacteria. tonsil specimens were cultured aerobically to allow identification and isolation of the bacterial pathogens staphylococcus aureus and group a streptococcus. tcr vβ subset analysis of tonsil leucocytes was performed b ... | 2017 | 28474248 |