Publications

Significant association of multiple human cytomegalovirus genomic Loci with glioblastoma multiforme samples.	Viruses are appreciated as etiological agents of certain human tumors, but the number of different cancer types induced or exacerbated by viral infections is unknown. Glioblastoma multiforme (GBM)/astrocytoma grade IV is a malignant and lethal brain cancer of unknown origin. Over the past decade, several studies have searched for the presence of a prominent herpesvirus, human cytomegalovirus (HCMV), in GBM samples. While some have detected HCMV DNA, RNA, and proteins in GBM tissues, others have ...	2012	22090104
multicentric castleman disease in an hhv-8-infected child born to consanguineous parents.	childhood multicentric castleman disease (mcd) is a rare and unexplained lymphoproliferative disorder. we report a human herpesvirus-8 (hhv-8)-infected child, born to consanguineous comorian parents, who displayed isolated mcd in the absence of any known immunodeficiency. we also systematically review the clinical features of the 32 children previously reported with isolated and unexplained mcd. the characteristics of this patient and the geographic areas of origin of most previous cases suggest ...	2012	22157133
Bacterial artificial chromosome clones of viruses comprising the towne cytomegalovirus vaccine.	Bacterial artificial chromosome (BAC) clones have proven invaluable for genetic manipulation of herpesvirus genomes. BAC cloning can also be useful for capturing representative genomes that comprise a viral stock or mixture. The Towne live attenuated cytomegalovirus vaccine was developed in the 1970s by serial passage in cultured fibroblasts. Although its safety, immunogenicity, and efficacy have been evaluated in nearly a thousand human subjects, the vaccine itself has been little studied. Inst ...	2012	22187535
kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induction by hypoxia and hypoxia-inducible factors.	hypoxia and hypoxia-inducible factors (hifs) play an important role in the kaposi's sarcoma-associated herpesvirus (kshv) life cycle. in particular, hypoxia can activate lytic replication of kshv and specific lytic genes, including the replication and transcription activator (rta), while kshv infection in turn can increase the levels and activity of hifs. in the present study, we show that hypoxia increases the levels of mrnas encoding kshv latency-associated nuclear antigen (lana) in primary ef ...	2012	22090111
novel virus-encoded microrna molecules expressed by ovine herpesvirus 2-immortalized bovine t-cells.	a number of herpesviruses have now been shown to encode micrornas (mirnas) that have roles in control of both viral and cellular gene expression. ovine herpesvirus 2 (ovhv-2) is the causative agent of sheep-associated malignant catarrhal fever, a fatal lymphoproliferative disease of cattle. using massively parallel sequencing and northern hybridization we have identified eight putative mirnas encoded by ovhv-2 expressed in an ovhv-2-immortalized bovine lymphocyte cell line. these eight mirnas ar ...	2012	21957125
Detection of herpes simplex virus (1 and 2), varicella-zoster virus, cytomegalovirus, human herpesvirus 6 and enterovirus in immunocompetent tunisian patients with acute neuromeningeal disorder.	Enteroviruses (EVs) and human herpesviruses (HHVs) are involved frequently in acute neurological disorders of viral etiology. This study aimed to investigate the incidence of herpes simplex virus types-1 (HSV-1) and 2 (HSV-2), varicella-zoster virus (VZV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6) and human enteroviruses (EVs) in cerebrospinal fluid (CSF) samples of Tunisian immunocompetent patients with neuromeningeal disorders. The patients had been hospitalized at the Fattouma Bourgu ...	2012	22170549