Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| a study of pre-operative presence of micro-organisms in affected knee joints of rheumatoid arthritis patients who need total knee arthroplasty. | to evaluate, by way of intraoperative tissue culture and pathological study, the pre-operative presence of micro-organisms in knee joints of patients with rheumatoid arthritis (ra) who need total knee arthroplasty (tka). | 2017 | 27919672 |
| universal contact precautions do not change the prevalence of antibiotic resistant organisms in a tertiary burn unit. | the prevalence of antibiotic-resistant organisms (aro) in burn units is increasing worldwide and contributes significantly to morbidity and mortality. study aims are to describe the burden of aros in burn patients admitted to a tertiary burn unit, to evaluate the impact of contact precautions implemented after an outbreak of antibiotic-resistant acinetobacter baumannii, and to identify possible predictors of aro acquisition. | 2017 | 27915096 |
| synthesis and antimicrobial studies of novel derivatives of 4-(4-formyl-3-phenyl-1h-pyrazol-1-yl)benzoic acid as potent anti-acinetobacter baumannii agents. | microbial resistance to antibiotics is a global concern. the world health organization (who) has identified antimicrobial resistance as one the three greatest threats for human beings in the 21st century. without urgent and coordinated action, the world is moving toward a post-antibiotic era, in which normal infections or minor injuries may become fatal. in an effort to find new agents, we report the synthesis and antimicrobial activities of 40 novel 1,3-diphenyl pyrazole derivatives. these comp ... | 2017 | 28065568 |
| epidemiology and control measures of outbreaks due to antibiotic-resistant organisms in europe (embargo): a systematic review protocol. | improving our understanding of outbreaks due to antibiotic-resistant bacteria (arb) and their control is critical in the current public health scenario. the threat of outbreaks due to arb requires multifaceted efforts. however, a global overview of epidemiological characteristics of outbreaks due to arb and effective infection control measures is missing. in this paper, we describe the protocol of a systematic review aimed at mapping and characterising the epidemiological aspects of outbreaks du ... | 2017 | 28057656 |
| manual resuscitators in successive use in the same patient: reservoir of multi- and extensively resistant bacteria. | to determine the bacterial load on manual resuscitators (mrs), swab samples of mr connectors from a brazilian intensive care unit were collected at time zero, and after 24 and 48h use in the same patient. from 20 mrs, a total of 54 bacteria were isolated: six at t=0, 17 at t=24, and 31 at t=48. staphylococcus aureus, acinetobacter baumannii, serratia marcescens, and pseudomonas aeruginosa were the predominant isolates, and multidrug resistance was widespread in all species. greater awareness of ... | 2017 | 28012582 |
| infectious disease exposures and outbreaks at a south african neonatal unit with review of neonatal outbreak epidemiology in africa. | hospitalized neonates are vulnerable to infection, with pathogen exposures occurring in utero, intrapartum, and postnatally. african neonatal units are at high risk of outbreaks owing to overcrowding, understaffing, and shared equipment. | 2017 | 28161461 |
| the antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis. | aditoprim (adp) has potential use as an antimicrobial agent in animals. however, its pharmacodynamic properties have not been systematically studied yet. in this study, the in vitro antibacterial activities of adp and its main metabolites were assayed, and the in vivo antibacterial efficacy of adp for the treatment of swine streptococcosis was evaluated. it was shown that salmonella and streptococcus from swine, escherichia coli and salmonella from chickens, e. coli, streptococcus, mannheimia, p ... | 2017 | 28145487 |
| evaluation of antimicrobial persistent activity of alcohol-based hand antiseptics against bacterial contamination. | the purpose of this study was to evaluate persistent activity of three alcohol-based antiseptics widely used in the clinical routine containing chlorhexidine, triclosan or mecetronium after hand disinfection. four tests were used to evaluate the antimicrobial activity of antiseptics on: (i) resident microbiota; (ii) nutrient agar plates (nap) subsequently inoculated with a test organism; and transient microbiota acquired by contact with dry hands (iii), or (iv) a wet inert surface that had been ... | 2017 | 28132117 |
| the role of universal stress proteins in bacterial infections. | universal stress proteins are ubiquitously expressed in bacteria, archaea and plants and other eukaryotes. a general property of usps is their role in adaptation of bacteria to oxidative stress, high temperature, low ph and/or hypoxia. there is increasing evidence that these proteins facilitate the adaption of bacterial pathogens to the human host environment, thereby facilitating colonisation and pathogenicity. usps in mycobacterium tuberculosis are well studied and may play a role in latency o ... | 2017 | 28120710 |
| nitroxoline: a broad-spectrum biofilm-eradicating agent against pathogenic bacteria. | bacterial biofilms are surface-attached communities of slow-growing or non-replicating bacteria tolerant to conventional antibiotic therapies. although biofilms are known to occur in ca. 80% of all bacterial infections, no therapeutic agent has been developed to eradicate bacteria housed within biofilms. we have discovered that nitroxoline, an antibacterial agent used to treat urinary tract infections, displays broad-spectrum biofilm-eradicating activities against major human pathogens, includin ... | 2017 | 28110918 |
| biofilm formation of achromobacter xylosoxidans on contact lens. | achromobacter spp. may contaminate lenses, lens cases, and contact lens solutions and cause ocular infections. the aim of this study was to investigate the possibility of isolated strain of achromobacter xylosoxidans to form biofilm on the surface of soft contact lenses (cl), to quantify the production of the formed biofilm, and compare it with the reference strains (pseudomonas aeruginosa, staphylococcus aureus, and haemophilus influenzae). bacterial strain isolated from one contact lens case w ... | 2017 | 28218002 |
| achromobacter xylosoxidans infection in cystic fibrosis siblings with different outcomes: case reports. | the clinical relevance of achromobacter xylosoxidans infection in cystic fibrosis (cf) remains controversial. this emerging agent in cf has been associated with increased lung inflammation, more frequent exacerbations and more severe lung disease. we describe a pair of cf siblings chronically colonized by the same multilocus genotype of a. xylosoxidans with different clinical courses, and assess whether this species may have developed any virulence traits and antimicrobial resistance that could ... | 2017 | 28138423 |
| interaction between methicillin-resistant staphylococcus aureus (mrsa) and acanthamoeba polyphaga. | the interactions that occur between bacteria and amoebae can give through mutual relations, where both organisms benefit from the association or parasitic in which one organism benefits at the expense of the other. when these organisms share the same environment, it can result in some changes in the growth of organisms, in adaptation patterns, in morphology, development or even in their ability to synthesize proteins and other substances. in this study, the interaction between acanthamoeba polyp ... | 2017 | 28258293 |
| role of pathogens in multiple sclerosis. | multiple sclerosis (ms) is an inflammatory demyelinating autoimmune disease of the central nervous system (cns). although the etiology of ms is unknown, genetic and environmental factors play a role. infectious pathogens are the likely environmental factors involved in the development of ms. pathogens associated with the development or exacerbation of ms include bacteria, such as mycoplasma pneumoniae and chlamydia pneumoniae, the staphylococcus aureus-produced enterotoxins that function as supe ... | 2017 | 24266364 |
| the ability of a colloidal silver gel wound dressing to kill bacteria in vitro and in vivo. | inhibiting bacterial biofilms is of major significance for proper wound healing. the choice of the dressing material plays a key role, as bacteria can live in dressings and keep reinfecting the wound. this study examines the effectiveness of a colloidal silver gel (ag-gel) wound dressing in inhibiting the growth of bacteria in a mouse wound model. | 2017 | 28379105 |
| interplay between antibiotic resistance and virulence during disease promoted by multidrug-resistant bacteria. | diseases caused by antibiotic-resistant bacteria in hospitals are the outcome of complex relationships between several dynamic factors, including bacterial pathogenicity, the fitness costs of resistance in the human host, and selective forces resulting from interventions such as antibiotic therapy. the emergence and fate of mutations that drive antibiotic resistance are governed by these interactions. in this review, we will examine how different forms of antibiotic resistance modulate bacterial ... | 2017 | 28375515 |
| structural modification of lipopolysaccharide conferred by mcr-1 in gram-negative eskape pathogens. | mcr-1 was initially reported as the first plasmid-mediated colistin resistance gene in clinical isolates of escherichia coli and klebsiella pneumoniae in china and has subsequently been identified worldwide in various species of the family enterobacteriaceae. mcr-1 encodes a phosphoethanolamine transferase and its expression has been shown to generate phosphoethanolamine-modified bis-phosphorylated hexa-acylated lipid a in e. coli here, we investigated the effect of mcr-1 on colistin susceptibil ... | 2017 | 28373195 |
| presence of multidrug-resistant organisms in the residents and environments of long-term care facilities in taiwan. | this study investigated the prevalence of multidrug-resistant organisms (mdros) in the residents and environments of long-term care facilities (ltcfs) in taiwan. | 2017 | 28373038 |
| factors associated with recurrent bacterial empyema thoracis. | empyema thoracis (et) is one of the common thoracic diseases frequently found in developing countries. in the past, only a few studies have analyzed recurrent et, and none had clearly identified the prognostic factors for recurrence. the aim of this study is to identify the prognostic factors of recurrent et in northern thailand. | 2017 | 28372933 |
| synergistic effects of antimicrobial peptide dp7 combined with antibiotics against multidrug-resistant bacteria. | antibiotic-resistant bacteria present a great threat to public health. in this study, the synergistic effects of antimicrobial peptides (amps) and antibiotics on several multidrug-resistant bacterial strains were studied, and their synergistic effects on azithromycin (azt)-resistance genes were analyzed to determine the relationships between antimicrobial resistance and these synergistic effects. a checkerboard method was used to evaluate the synergistic effects of amps (dp7 and cls001) and seve ... | 2017 | 28356719 |
| n6', n6''', and o4' modifications to neomycin affect ribosomal selectivity without compromising antibacterial activity. | the synthesis of a series of neomycin derivatives carrying the 2-hydroxyethyl substituent on n6' and/or n6‴ both alone and in combination with a 4'-o-ethyl group is described. by means of cell-free translation assays with wild-type bacterial ribosomes and their hybrids with eukaryotic decoding a sites, we investigate how individual substituents and their combinations affect activity and selectivity at the target level. in principle, and as shown by cell-free translation assays, modifications of ... | 2017 | 28343384 |
| evaluating the effect of peptoid lipophilicity on antimicrobial potency, cytotoxicity, and combinatorial library design. | growing prevalence of antibiotic resistant bacterial infections necessitates novel antimicrobials, which could be rapidly identified from combinatorial libraries. we report the use of the peptoid library agar diffusion (plad) assay to screen peptoid libraries against the eskape pathogens, including the optimization of assay conditions for each pathogen. work presented here focuses on the tailoring of combinatorial peptoid library design through a detailed study of how peptoid lipophilicity relat ... | 2017 | 28291947 |
| characterizing the antimicrobial activity of n(2), n(4) -disubstituted quinazoline-2,4-diamines towards multidrug resistant acinetobacter baumannii. | we previously reported a series of n(2) ,n(4) -disubstituted quinazoline-2,4-diamine as dihydrofolate reductase inhibitors, with potent in vitro and in vivo antibacterial activity against mrsa strains. in this work we extend our previous study to the gram-negative pathogen acinetobacter baumannii we determined that optimized n(2) ,n(4) -disubstituted quinazoline-2,4-diamines are strongly antibacterial against multi-drug resistant a. baumannii strains when the 6-position is substituted with a hal ... | 2017 | 28289036 |
| persistent nasal carriers of acinetobacter baumannii in long-term-care facilities. | acinetobacter baumannii and staphylococcus aureus have persisted as 2 major pathogens worldwide. | 2017 | 28284750 |
| natural antimicrobial peptide complexes in the fighting of antibiotic resistant biofilms: calliphora vicina medicinal maggots. | biofilms, sedimented microbial communities embedded in a biopolymer matrix cause vast majority of human bacterial infections and many severe complications such as chronic inflammatory diseases and cancer. biofilms' resistance to the host immunity and antibiotics makes this kind of infection particularly intractable. antimicrobial peptides (amps) are a ubiquitous facet of innate immunity in animals. however, amps activity was studied mainly on planktonic bacteria and little is known about their e ... | 2017 | 28278280 |
| fluorescence high-throughput screening for inhibitors of tonb action. | gram (-) bacteria acquire ferric siderophores through tonb-dependent outer membrane transporters (tbdt). by fluorescence spectroscopic high-throughput screening (flhts) we identified inhibitors of tonb-dependent ferric enterobactin (feent) uptake through e. coli fepa (ecofepa). among 165 inhibitors found in a primary screen of 17,441 compounds, we evaluated 20 in secondary tests: tonb-dependent ferric siderophore uptake and colicin killing; proton-motive force-dependent lactose transport. 6 of 2 ... | 2017 | 28242720 |
| mechanical ventilator as a major cause of infection and drug resistance in intensive care unit. | ventilator-associated pneumonia (vap) is the most frequent infection in intensive care units (icu). it is associated with high rates of long morbidity and mortality. management of a case of vap is often said to add $40,000 to hospital costs usa. all these data directed our interest to study the etiology, risk factors, and antibiotic susceptibility patterns of vap in icu of tanta university hospital. this study included 36 cases of vap. endotracheal aspirates were obtained from all cases and micr ... | 2017 | 28233206 |
| increasing resistance to extended-spectrum cephalosporins, fluoroquinolone, and carbapenem in gram-negative bacilli and the emergence of carbapenem non-susceptibility in klebsiella pneumoniae: analysis of korean antimicrobial resistance monitoring system (karms) data from 2013 to 2015. | national surveillance of antimicrobial resistance becomes more important for the control of antimicrobial resistance and determination of treatment guidelines. we analyzed korean antimicrobial resistance monitoring system (karms) data collected from 2013 to 2015. | 2017 | 28224769 |
| can contaminated water be rendered safe for nasal saline irrigations? | to compare sterile water to three methods of sterilization (carbon filtration, boiling, and ultraviolet [uv] light) for preparation of nasal saline irrigants free of bacterial and amebic contaminants. | 2017 | 28224696 |
| novel bacterial topoisomerase inhibitors with potent broad-spectrum activity against drug-resistant bacteria. | the novel bacterial topoisomerase inhibitor class is an investigational type of antibacterial inhibitor of dna gyrase and topoisomerase iv that do not have cross-resistance with the quinolones. here, we report the evaluation of the in vitro properties of a new series of this type of small molecules. exemplar compounds selectively and potently inhibited the catalytic activities of escherichia coli dna gyrase and topoisomerase iv but did not block the dna breakage-reunion step. compounds showed br ... | 2017 | 28223393 |
| [significance of bacteria detection with filter paper method on diagnosis of diabetic foot wound infection]. | objective: to evaluate the significance of bacteria detection with filter paper method on diagnosis of diabetic foot wound infection. methods: eighteen patients with diabetic foot ulcer conforming to the study criteria were hospitalized in liyuan hospital affiliated to tongji medical college of huazhong university of science and technology from july 2014 to july 2015. diabetic foot ulcer wounds were classified according to the university of texas diabetic foot classification (hereinafter referre ... | 2017 | 28219141 |
| potassium iodide potentiates broad-spectrum antimicrobial photodynamic inactivation using photofrin. | it is known that noncationic porphyrins such as photofrin (pf) are effective in mediating antimicrobial photodynamic inactivation (apdi) of gram-positive bacteria or fungi. however, the apdi activity of pf against gram-negative bacteria is accepted to be extremely low. here we report that the nontoxic inorganic salt potassium iodide (ki) at a concentration of 100 mm when added to microbial cells (10(8)/ml) + pf (10 μm hematoporphyrin equivalent) + 415 nm light (10 j/cm(2)) can eradicate (>6 log ... | 2017 | 28207234 |
| antibacterial effect of sevoflurane and isoflurane. | multidrug resistant bacteria are increasing worldwide and therapeutic options are limited. some anaesthetics have shown antibacterial activity before. in this study, we have investigated the antibacterial effect of the halogenated anaesthetic agents sevoflurane and isoflurane against a range of resistant pathogens. | 2017 | 28198170 |
| patients hospitalized abroad as importers of multiresistant bacteria-a cross-sectional study. | the pandemic spread of multidrug-resistant (mdr) bacteria poses a threat to healthcare worldwide, with highest prevalence in indigent regions of the (sub)tropics. as hospitalization constitutes a major risk factor for colonization, infection control management in low-prevalence countries urgently needs background data on patients hospitalized abroad. | 2017 | 28196696 |
| in vitro screening of an fda-approved library against eskape pathogens. | bacterial resistance to conventional antibiotics is an increasingly serious threat to public health worldwide that requires immediate exploration and the development of novel antimicrobial compounds. drug repurposing is an inexpensive and untapped source of new antimicrobial leads, and it holds many attractive features warranting further attention for antimicrobial drug discovery. in an effort to repurpose drugs and explore new leads in the field of antimicrobial drug discovery, we performed a w ... | 2017 | 28190396 |
| aetiology and significance of hospital-acquired infections in mexico. | hospital-acquired infections (hais) are infections that develop in the hospital environment and can be acquired by a patient or hospital staff. they are complications that combine diverse risk factors that make an individual susceptible and are frequently caused by endogenous and exogenous bacterial agents. the most commonly studied etiological agents are bacteria and fungi, with the former representing the most common etiological agents reported to the hospital epidemiological surveillance netw ... | 2017 | 28182358 |
| in vitro activity of a polyhexanide-betaine solution against high-risk clones of multidrug-resistant nosocomial pathogens. | to determine the in vitro activity of a polyhexanide-betaine solution against collection strains and multidrug-resistant (mdr) nosocomial isolates, including high-risk clones. | 2017 | 27004429 |
| antimicrobial susceptibility among european gram-negative and gram-positive isolates collected as part of the tigecycline evaluation and surveillance trial (2004-2014). | european centers (n = 226) involved in the tigecycline evaluation and surveillance trial (test, 2004-2014) submitted data and bacterial isolates. | 2017 | 27216271 |
| structure-activity relationship-based screening of antibiotics against gram-negative acinetobacter baumannii. | to discover potent antibiotics against the gram-negative bacteria, we performed a structure-activity relationship (sar) study of yksa-6, which was the most potent inhibitor of staphylococcus aureus β-ketoacyl acyl carrier protein iii in our previous study. we identified and selected 11 candidates, and finally screened two active compounds, ykab-4 (4-[(3-chloro-4-methylphenyl)aminoiminomethyl]benzene-1,3-diol) and ykab-6 (4-[[3-(trifluoromethyl)phenyl]aminoiminomethyl]phenol) as inhibitors of aci ... | 2017 | 27840136 |
| classical β-lactamase inhibitors potentiate the activity of daptomycin against methicillin-resistant staphylococcus aureus and colistin against acinetobacter baumannii. | we asked whether beta-lactamase inhibitors (blis) increased the activity of daptomycin (dap) against methicillin-resistant staphylococcus aureus (mrsa), the peptide antibiotic colistin (col) against the emerging gram-negative nosocomial pathogen acinetobacter baumannii, and the human host defense peptide cathelicidin ll37 against either pathogen. dap and ll37 kill curves were performed with or without blis against mrsa, vancomycin-intermediate s. aureus (visa), and heterogeneous visa (hvisa). co ... | 2017 | 27872080 |
| association of biofilm production with colonization among clinical isolates of acinetobacter baumannii. | the pathogen acinetobacter baumannii is increasingly causing healthcare-associated infections worldwide, particularly in intensive care units. biofilm formation, a factor contributing to the virulence of a. baumannii, is associated with long-term persistence in hospital environments. the present study investigates the clinical impact of biofilm production on colonization and acquisition after patient admission. | 2017 | 27653617 |
| the ability of quaternary ammonium groups attached to a urethane bandage to inhibit bacterial attachment and biofilm formation in a mouse wound model. | for proper wound healing, control of bacteria or bacterial infections is of major importance. while caring for a wound, dressing material plays a key role as bacteria can live in the bandage and keep re-infecting the wound. they do this by forming biofilms in the bandage, which slough off planktonic bacteria and overwhelm the host defense. it is thus necessary to develop a wound dressing that will inhibit bacterial growth. this study examines the effectiveness of a polyurethane foam wound dressi ... | 2017 | 26712337 |
| broad-range detection of microorganisms directly from bronchoalveolar lavage specimens by pcr/electrospray ionization-mass spectrometry. | the clinical demand on rapid microbiological diagnostic is constantly increasing. pcr coupled to electrospray ionization-mass spectrometry, pcr/esi-ms, offers detection and identification of over 750 bacteria and candida species directly from clinical specimens within 6 hours. in this study, we investigated the clinical performance of the iridica bac lrt assay for detection of bacterial pathogens in 121 bronchoalveolar lavage (bal) samples that were received consecutively at our bacterial labora ... | 2017 | 28085931 |
| clumping factor a of staphylococcus aureus interacts with annexina2 on mammary epithelial cells. | staphylococcus aureus is one of major pathogens that can cause a series of diseases in different hosts. in the bovine, it mainly causes subclinical and contagious mastitis, but its mechanisms of infection are not fully understood. considering the fact that virulence factors play key roles in interactions between the bacterium and host cells, this study aimed to identify if a binding partner of s. aureus clumping factor a (clfa) exists on the bovine mammary epithelial cells. the clfa protein was ... | 2017 | 28102235 |
| antibacterial activities of the methanol extract, fractions and compounds from elaeophorbia drupifera (thonn.) stapf. (euphorbiaceae). | elaeophorbia drupifera (thonn.) stapf. (euphorbiaceae) is used in cameroonian folk medicine to treat several ailments including bacterial-related diseases such as skin infections. in this study, the methanol extract from the leaves (edl), fractions (edla-d), sub-fractions edlc1-7 and edlc31-35 as well as isolated compounds were tested for their antimicrobial activities against a panel of gram-negative and gram-positive bacteria including multidrug resistant (mdr) phenotypes. | 2017 | 28061888 |
| glycin-rich antimicrobial peptide yd1 from b. amyloliquefaciens, induced morphological alteration in and showed affinity for plasmid dna of e. coli. | antimicrobial peptides (amps), low-molecular-weight proteins with broad-spectrum antimicrobial activity, are the most promising candidates for the development of novel antimicrobials. a powerful cationic glycine-rich amp yd1 (mw ~ 1.0 kda) was purified from bacillus amyloliquefaciens cbsyd1 isolated from traditional korean fermented food kimchi, for the treatment of multidrug-resistant (mdr) bacteria. strain cbsyd1 was identified 99.79% similar to bacillus amyloliquefaciens subsp. plantarum fzb4 ... | 2017 | 28050849 |
| whole-genome sequencing of invasion-resistant cells identifies laminin α2 as a host factor for bacterial invasion. | to understand the role of glycosaminoglycans in bacterial cellular invasion, xylosyltransferase-deficient mutants of chinese hamster ovary (cho) cells were created using clustered regularly interspaced short palindromic repeat (crispr) and crispr-associated gene 9 (crispr-cas9) gene targeting. when these mutants were compared to the pgsa745 cell line, a cho xylosyltransferase mutant generated previously using chemical mutagenesis, an unexpected result was obtained. bacterial invasion of pgsa745 ... | 2017 | 28074024 |
| in vitro activity of linezolid in combination with photodynamic inactivation against staphylococcus aureus biofilms. | biofilm infections are a major challenge in medical practice. bacteria that live in a biofilm phenotype are more resistant to both antimicrobial therapy and host immune responses compared to their planktonic counterparts. so, there is need for new therapeutic strategies to combat these infections. a promising approach [known as photodynamic inactivation (pdi)] to kill bacteria growing as biofilms uses light in combination with a photosensitizer to induce a phototoxic reaction which produces reac ... | 2017 | 28090280 |
| isolation and identification of phyllospheric bacteria possessing antimicrobial activity from astragalus obtusifolius, prosopis juliflora, xanthium strumarium and hippocrepis unisiliqousa. | the widespread utilization of antimicrobial compounds has caused emergence of resistant microorganisms in the world. hence, the research to probe the products with antimicrobial features has led to finding natural habitats and discovering new pharmaceutical products. | 2017 | 28090278 |
| secondary metabolites from bacillus amyloliquefaciens isolated from soil can kill burkholderia pseudomallei. | bacillus species are gram-positive bacteria found in abundance in nature and their secondary metabolites were found to possess various potential activities, notably antimicrobial. in this study, bacillus amyloliquefaciens n2-4 and n3-8 were isolated from soil and their metabolites could kill burkholderia pseudomallei, a gram-negative pathogenic bacterium also found in soil in its endemic areas. moreover, the metabolites were able to kill drug resistant isolates of b. pseudomallei and also inhibi ... | 2017 | 28050857 |
| infective endocarditis risk after percutaneous pulmonary valve implantation with the melody and sapien valves. | this study compared the risk of infective endocarditis (ie) after percutaneous pulmonary valve implantation (ppvi) with the sapien and melody valves. | 2017 | 28279319 |
| antibacterial activity of tribulus terrestris and its synergistic effect with capsella bursa-pastoris and glycyrrhiza glabra against oral pathogens: an in-vitro study. | in this study, antimicrobial activities of an ethanol extract of tribulus terrestris aloneand in combination with capsella bursa-pastoris and glycyrrhiza glabra were examined in vitro against six pathogens namely streptococcus mutans, streptococcus sanguis, actinomyces viscosus, enterococcus faecalis staphylococcus aureus, and escherichia coli. | 2017 | 26101754 |
| secondary bacterial isolates from previously untreated buruli ulcer lesions and their antibiotic susceptibility patterns in southern nigeria. | mycolactones, secreted by mycobacterium ulcerans, were previously believed to prevent super infection in buruli ulcer lesions. however, little is known about secondary bacterial infections in these lesions. this study evaluated contaminating bacterial flora and their antibiotic susceptibility patterns in cases of previously untreated buruli ulcer disease from three states in southern nigeria. | 2017 | 28001222 |
| identification of ly2 members as antimicrobial peptides from zebrafish danio rerio. | the emergence of multidrug-resistant (mdr) microbes caused by overuse of antibiotics leads to urgent demands for novel antibiotics exploration. our recent data showed that ly2.1-3 (a novel lymphocyte antigen 6 (ly6) gene cluster) were proteins with cationic nature and rich in cysteine content, that are characteristic of antimicrobial peptides (amps) and their expression were all significantly up-regulated after challenge with lipopolysaccharide (lps). these strongly suggested that ly2.1-3 are po ... | 2017 | 27980020 |
| dietary myrtle (myrtus communis l.) improved non-specific immune parameters and bactericidal activity of skin mucus in rainbow trout (oncorhynchus mykiss) fingerlings. | the present study examined the effects of dietary myrtle (myrtus communis l.) on non-specific immune parameters and bactericidal activity of skin mucus in rainbow trout (oncorhynchus mykiss) fingerlings. three hundred and sixty fingerlings (6.50 ± 0.55 g (were distributed in twelve cages (65 × 65 × 65 cm) with a metal framework. the study included four treatments repeated in triplicates. the treatments were feeding trouts with experimental diets containing different levels (0, 0.5, 1 and 1.5%) o ... | 2017 | 28330807 |
| a galectin contributes to the innate immune recognition and elimination of pathogens in the freshwater mussel hyriopsis cumingii. | galectins are members of the lectin superfamily. they function as pattern recognition receptors in the innate immune system of vertebrates and invertebrates. a galectin homolog from the triangle sail mussel hyriopsis cumingii (hcgal2) was cloned and characterized. hcgal2 mrna was expressed in all tissues examined, displaying particular enrichment in mantle tissue. interestingly, rhcgal2 protein was only detected in the mantle, hemocytes, and gills, suggesting that post-transcriptional regulation ... | 2017 | 28300581 |
| bacterial coaggregation among the most commonly isolated bacteria from contact lens cases. | to examine the coaggregation and cohesion between the commonly isolated bacteria from contact lens cases. | 2017 | 28061510 |
| the effect of seasons on brazilian red propolis and its botanical source: chemical composition and antibacterial activity. | the aim of this study was to evaluate the effect of seasons on the chemical composition and antibacterial activity of brazilian red propolis (brp) and its plant source. brp was collected from maceio, alagoas state, north-east of brazil, during one year. chemical composition was determined by physicochemical analyses and hplc while antimicrobial activity was assessed against streptococcus mutans, streptococcus sobrinus, staphylococcus aureus and actinomyces naeslundii by determining the minimal i ... | 2017 | 27701899 |
| clinical and microbiological characteristics of bloodstream infections among patients with haematological malignancies with and without neutropenia at a medical centre in northern taiwan, 2008-2013. | this study aimed to investigate the epidemiology and microbiology of bloodstream infections (bsis) in patients with haematological malignancies. clinical characteristics and microbiology of 2083 patients with haematological malignancy who were treated for bsi from 2008 to 2013 at a medical centre in taiwan were retrospectively reviewed. lymphoma (38.1%) was the most common, followed by acute myeloid leukaemia (30.9%). of the 2090 non-duplicate bsi isolates, 1310 (62.7%) were recovered from patie ... | 2017 | 28109554 |
| evasion of neutrophil extracellular traps by respiratory pathogens. | the release of neutrophil extracellular traps (nets) is a major immune mechanism intended to capture pathogens. these histone- and protease-coated dna structures are released by neutrophils in response to a variety of stimuli, including respiratory pathogens, and have been identified in the airways of patients with respiratory infection, cystic fibrosis, acute lung injury, primary graft dysfunction, and chronic obstructive pulmonary disease. net production has been demonstrated in the lungs of m ... | 2017 | 27854516 |
| bactericidal and fungicidal activity of n-chlorotaurine is enhanced in cystic fibrosis sputum medium. | lung infections with multiresistant pathogens are a major problem of patients suffering from cystic fibrosis (cf). n-chlorotaurine (nct), a microbicidal active chlorine compound with no resistance development, is well tolerated upon inhalation. the aim of this study was to investigate nct on its bactericidal and fungicidal activity in vitro in artificial sputum medium (asm) mimicking the composition of cystic fibrosis mucus.the medium was inoculated with bacteria (staphylococcus aureus including ... | 2017 | 28223376 |
| chemical characteristics, antimicrobial and cytotoxic activities of the essential oil of egyptian cinnamomum glanduliferum bark. | the essential oil isolated from the bark of cinnamomum glanduliferum (wall) meissn that grown in egypt was screened for the first time. the chemical composition was analyzed by gc and gc/mass. the antimicrobial activity of the oil was assessed using agar-well diffusion method toward representatives for each of gram-positive bacteria, gram-negative bacteria, and fungi. the cytotoxic activity was checked using three human cancer cell lines. twenty seven compounds were identified, representing 99.0 ... | 2017 | 28190283 |
| synthesis and biological evaluation of a new series of benzimidazole derivatives as antimicrobial, antiquorum-sensing and antitumor agents. | new benzimidazole derivatives were synthesized and assessed for antimicrobial efficacy toward escherichia coli, bacillus cereus, staphylococcus aureus, candida albicans and aspergillus fumigatus 293. results indicated that compounds 3c and 3n have promising activity toward s. aureus, whereas 3i exhibited remarkable efficacy toward b. cereus. moreover, compound 3c was proved to be the most active antifungal analog toward c. albicans. on the other hand, 3n displayed the highest activity against a. ... | 2017 | 28334654 |
| antimicrobial properties of black grape (vitis vinifera l.) peel extracts against antibiotic-resistant pathogenic bacteria and toxin producing molds. | black grape peel possesses a substantial amount of polyphenolic antimicrobial compounds that can be used for controlling the growth of pathogenic microorganisms. the purpose of this study was to assess antibacterial and antifungal activity of black grape peel extracts against antibiotic-resistant pathogenic bacteria and toxin producing molds, respectively. | 2017 | 26729960 |
| establishment of the inducible tet-on system for the activation of the silent trichosetin gene cluster in fusarium fujikuroi. | the pks-nrps-derived tetramic acid equisetin and its n-desmethyl derivative trichosetin exhibit remarkable biological activities against a variety of organisms, including plants and bacteria, e.g., staphylococcus aureus. the equisetin biosynthetic gene cluster was first described in fusarium heterosporum, a species distantly related to the notorious rice pathogen fusarium fujikuroi. here we present the activation and characterization of a homologous, but silent, gene cluster in f. fujikuroi. bio ... | 2017 | 28379186 |
| n-heterocyclic choline analogues based on 1,2,3,4-tetrahydro(iso)quinoline scaffold with anticancer and anti-infective dual action. | pharmacological effects of biologically active "small molecules" can be improved by their targeted modification, which affects drug delivery and interaction with tumor cells and microorganisms. we aimed to evaluate anticancer and antimicrobial activity of lipid-like choline derivatives modified via simultaneous introduction of tetrahydro(iso)quinoline based pharmacophore system at nitrogen atom and long chain alkyl substituent at oxygen atom. | 2017 | 28364698 |
| comparison of survivability of staphylococcus aureus and spores of aspergillus niger on commonly used floor materials. | the survivability of staphylococcus aureus and spores of aspergillus niger was compared on 5 common floor materials. | 2017 | 28318645 |
| effects of potassium sulfate [k2so4] on the element contents, polyphenol content, antioxidant and antimicrobial activities of milk thistle [silybum marianum]. | silybum marianum l. (milk thistle) is native to the mediterranean basin and is now widespread throughout the world. it's sprout is used as a herbal medicine for the treatment of liver disease for centuries. the seeds of milk thistle contain silymarin, an isomeric mixture of flavonolignans [silybin, silychristin, and silydianin]. silymarin acts as a strong anti-hepatotoxic. | 2017 | 28216891 |
| synthesis, structure and antimicrobial properties of novel benzalkonium chloride analogues with pyridine rings. | quaternary ammonium compounds (qacs) are a group of compounds of great economic significance. they are widely used as emulsifiers, detergents, solubilizers and corrosion inhibitors in household and industrial products. due to their excellent antimicrobial activity qacs have also gained a special meaning as antimicrobials in hospitals, agriculture and the food industry. the main representatives of the microbiocidal qacs are the benzalkonium chlorides (bacs), which exhibit biocidal activity agains ... | 2017 | 28098790 |
| evaluation of wound healing, anti-microbial and antioxidant potential of pongamia pinnata in wistar rats. | to investigate wound healing, antimicrobial and antioxidant activity of leaf extract of pongamia pinnata. | 2017 | 28053891 |
| antimicrobial assay and genetic screening of selected freshwater cyanobacteria and identification of a biomolecule dihydro-2h-pyran-2-one derivative. | explorations of freshwater cyanobacteria as antimicrobial (bacteria, fungi and methicillin-resistant staphylococcus aureus (mrsa) strains) drug resource using bioassay, nrps (non-ribosomal polypeptide synthetase) and pks (polyketide synthase) genes, as well as in silico approach. | 2017 | 28004519 |
| preparation and characterization of intelligent starch/pva films for simultaneous colorimetric indication and antimicrobial activity for food packaging applications. | we have developed an intelligent starch/poly-vinyl alcohol (pva) film that is capable of monitoring ph changes and inhibiting undesired microbial growth in foods. starch and pva polymers in the film were doubly cross-linked by sodium trimetaphosphate and boric acid to improve their water-resistance and mechanical strength. anthocyanins (ant) and limonene (lim) were used to achieve simultaneous colorimetric indication and antimicrobial activity. firstly, the characterization of surface morphology ... | 2017 | 27987998 |
| structural, textural and morphological characteristics of tannins from acacia mearnsii encapsulated using sol-gel methods: applications as antimicrobial agents. | tannins from acacia mearnsii were encapsulated using four different sol-gel methods acid (sgar), basic (sgbr), silicate (sgsr) and non-hydrolytic (sgnhr) routes. the hybrid materials were analyzed using a set of techniques to characterize their structure, texture and morphology. the antimicrobial performance of the encapsulated materials was evaluated against different microorganisms (staphylococcus aureus, escherichia coli, aspergillus niger and candida sp.). the data showed that the encapsulat ... | 2017 | 27940166 |
| effects of β-caryophyllene and murraya paniculata essential oil in the murine hepatoma cells and in the bacteria and fungi 24-h time-kill curve studies. | orange jessamine [murraya paniculata l. (rutaceae)] has been used worldwide in folk medicine as an anti-inflammatory, antibiotic and analgesic. | 2017 | 27927082 |
| synthesis and antimicrobial evaluation of ester-linked 1,4-disubstituted 1,2,3-triazoles with a furyl/thienyl moiety. | twenty ester-linked 1,4-disubstituted 1,2,3-triazoles having a furyl/thienyl moiety have been synthesized from heteroaryl prop-2-yn-1-yl carboxylate and aromatic azides via a cu(i) catalyzed 1,3-dipolar cycloaddition. all the synthesized compounds were characterized by ftir, [formula: see text]h nmr, [formula: see text]c nmr spectroscopy and hrms. synthesized triazoles were tested in vitro for antimicrobial evaluation against gram-negative bacteria-escherichia coli, enterobacter aerogenes and kl ... | 2017 | 27900513 |
| antimicrobial metal-based thiophene derived compounds. | a novel series of thiophene derived schiff bases and their transition metal- [co(ii), cu(ii), zn(ii), ni(ii)] based compounds are reported. the schiff bases act as tridentate ligands toward metal ions via azomethine-n, deprotonated-n of ammine substituents and s-atom of thienyl moiety. the synthesized ligands along with their metal complexes were screened for their in vitro antibacterial activity against six bacterial pathogens (escherichia coli, shigella flexneri, pseudomonas aeruginosa, salmon ... | 2017 | 27766891 |
| design, synthesis and spectroscopic characterization of metal (ii) complexes derived from a tetradentate macrocyclic ligand: study on antimicrobial and antioxidant capacity of complexes. | the paper presents the synthesis of co(ii), ni(ii) and cu(ii) complexes of macrocyclic schiff base ligand derived from 1, 4-dicarbonyl-phenyl-dihydrazide and ethyl 3-oxobutanoate (2:2). the synthesized ligand and its metal complexes were characterized by elemental analyses, magnetic susceptibility measurements, ftir, uv-vis., mass (1)h nmr and x-ray diffraction. the cu(ii) complex exhibit distorted octahedral geometry, whereas an octahedral geometry is suggested for other complexes. the synthesi ... | 2017 | 28126666 |
| multifunctional nanocomposites of chitosan, silver nanoparticles, copper nanoparticles and carbon nanotubes for water treatment: antimicrobial characteristics. | multifunctional nanocomposites of chitosan with silver nanoparticles, copper nanoparticles and carbon nanotubes either as bi- or multifunctional nanocomposites were prepared. change in the overall morphology of the prepared nanocomposites was observed; carbon nanotubes, ag nps and cu nps are distributed homogeneously inside the polymer matrix individually in the case of the bi-nanocomposites while a combination of different dimensional shapes; spherical nps and nanotubes was observed in the mult ... | 2017 | 28082228 |
| synthesis and biological evaluation of newer 1,3,4-oxadiazoles incorporated with benzothiazepine and benzodiazepine moieties. | a series of thiazepines and diazepines having 1,3,4-oxadiazole moiety were synthesized, and they were analyzed for their in vitro antimicrobial activity against several bacteria (staphylococcus aureus, staphylococcus pyogenes, escherichia coli, and pseudomonas aeruginosa) and fungi (candida albicans, aspergillus niger, and aspergillus clavatus) and protozoa (entamoeba histolytica, giardia lamblia, trypanosoma cruzi and leishmania mexicana). few of the selected compounds were tested for their ant ... | 2017 | 28182579 |
| microbiology of otitis media in indigenous australian children: review. | to review research addressing the polymicrobial aetiology of otitis media in indigenous australian children in order to identify research gaps and inform best practice in effective prevention strategies and therapeutic interventions. | 2017 | 28088924 |
| evaluation of phenolic compounds and antioxidant and antimicrobial activities of some common herbs. | the study was designed to evaluate the phenolic, flavonoid contents and antioxidant and antimicrobial activities of onion (allium cepa), garlic (allium sativum), mint (mentha spicata), thyme (thymus vulgaris), oak (quercus), aloe vera (aloe barbadensis miller), and ginger (zingiber officinale). all extracts showed a wide range of total phenolic contents, that is, 4.96 to 98.37 mg/100 g gallic acid equivalents, and total flavonoid contents, that is, 0.41 to 17.64 mg/100 g catechin equivalents. an ... | 2017 | 28316626 |
| the effect of calprotectin on tslp and il-25 production from airway epithelial cells. | calprotectin is a heterodimer complex of the s100a8 and s100a9 proteins, and has various functions as an innate mediator at the sites of inflammation. the aim of this study was to elucidate the roles of calprotectin in the eosinophilic chronic rhinosinusitis (ecrs). | 2017 | 27475624 |
| synthesis and antimicrobial properties of 4-acylaminobenzenethiosulfoacid s-esters. | a series of esters of 4-acetyl, 4-trifluoroacetyl- and 4-(3-chloropropionyl)aminobenzenethiosulfoacids (twenty-four compounds) were synthesized and characterized by elemental analysis, (1)h nmr and ir spectroscopy. the antibacterial activity of the novel candidates has been screened using the agar diffusion or serial dilution methods against representative gram-positive (staphylococcus aureus, bacillus subtilis, bacillus mesentericus, mycobacterium sp., mycobacterium luteum), gram-negative (aero ... | 2017 | 28344478 |
| evaluation of the antibacterial potential of liquid and vapor phase phenolic essential oil compounds against oral microorganisms. | the aim of the present study was to determine the antibacterial activities of the phenolic essential oil (eo) compounds hinokitiol, carvacrol, thymol, and menthol against oral pathogens. aggregatibacter actinomycetemcomitans, streptococcus mutans, methicillin-resistant staphylococcus aureus (mrsa), and escherichia. coli were used in this study. the minimum inhibitory concentrations (mics), minimum bactericidal concentrations (mbcs), bacterial growth curves, temperature and ph stabilities, and sy ... | 2017 | 27681039 |
| antimicrobial activity of biogenically produced spherical se-nanomaterials embedded in organic material against pseudomonas aeruginosa and staphylococcus aureus strains on hydroxyapatite-coated surfaces. | in an effort to prevent the formation of pathogenic biofilms on hydroxyapatite (ha)-based clinical devices and surfaces, we present a study evaluating the antimicrobial efficacy of spherical biogenic se-nanostructures embedded in organic material (bio se-nemo-s) produced by bacillus mycoides selte01 in comparison with two different chemical selenium nanoparticle (senp) classes. these nanomaterials have been studied as potential antimicrobials for eradication of established ha-grown biofilms, for ... | 2017 | 28233476 |
| hydrocarbon-stapled lipopeptides exhibit selective antimicrobial activity. | antimicrobial peptides (amps) occur widely in nature and have been studied for their therapeutic potential. amps are of interest due to the large number of possible chemical structural combinations using natural and unnatural amino acids, with varying effects on their biological activities. using physicochemical properties from known naturally occurring amphipathic cationic amps, several hydrocarbon-stapled lipopeptides (hslps) were designed, synthesized, and tested for antimicrobial properties. ... | 2017 | 28073163 |
| a novel c-type lectin in the black tiger shrimp penaeus monodon functions as a pattern recognition receptor by binding and causing bacterial agglutination. | c-type lectins are pattern recognition proteins that play important roles in innate immunity in invertebrates by mediating the recognition of pathogens. in this study, a novel c-type lectin gene, pmclec, was cloned and characterized from the black tiger shrimp penaeus monodon. the open reading frame of pmclec is 657 bp in length. it encodes a predicted protein of 218 amino acids with a calculated molecular mass and an isoelectric point of 24086 da and 4.67, respectively. sequence analysis of pmc ... | 2017 | 27876622 |
| silver nanoparticles as an antimicrobial agent: a case study on staphylococcus aureus and escherichia coli as models for gram-positive and gram-negative bacteria. | the current research was focused on the characterization and antimicrobial activity of silver nanoparticles (agnps) produced by bacillus licheniformis nm120-17. the synthesis was initially observed by a colour change from pale yellow to brown which was further confirmed by uv-vis spectroscopy. the agnps were characterized using tem, edax and ftir. the synthesized nanoparticles were found to be spherical and uniformly distributed with a size in the range of 9-27.5 nm. the antibacterial activities ... | 2017 | 28123131 |
| the difference in in vivo sensitivity between bacillus licheniformis perr and bacillus subtilis perr is due to the different cellular environments. | perr, a member of fur family of metal-dependent regulators, is a major peroxide sensor in many gram positive bacteria, and controls the expression of genes involved in peroxide resistance. bacillus licheniformis, a close relative to the well-studied model organism bacillus subtilis, contains three perr-like proteins (perrbl, perr2 and perr3) in addition to fur and zur. in the present study, we characterized the role of perrbl in b. licheniformis. in vitro and in vivo studies indicate that perrbl ... | 2017 | 28104400 |
| combating drug resistant pathogenic bacteria isolated from clinical infections, with silver oxide nanoparticles. | the antibiogram study of methicillin resistant staphylococcus aureus isolates revealed 100% resistance to vancomycin, bacitracin, erythromycin, ciprofloxacin and nalidixic acid. eight isolates (53.3%) showed resistance to co-trimoxazole and one isolate to rifampicin, which was the drug of choice. an effort was made to evaluate the antimethicillin resistant staphylococcus aureus activity of silver oxide (ag2o) nanoparticles synthesized from aspergillus terreus vit 2013. production of ag2o nanopar ... | 2017 | 26009646 |
| new metabolites from the sponge-derived fungus aspergillus sydowii j05b-7f-4. | two new metabolites, diorcinolic acid (1) and β-d-glucopyranosyl aspergillusene a (8), together with six diphenylethers (2-7), a diketopiperazine (9), a chromone (10) and a xanthone (11) were isolated from the fungus aspergillus sydowii derived from the marine sponge stelletta sp. the planar structures and their relative configurations were elucidated by analysing 1d, 2d nmr and hresims data. compound 8 is the first glycoside of phenolic bisabolane sesquiterpenes. compounds 1 and 8 exhibited mil ... | 2017 | 28278674 |
| potential immunomodulatory effects of non-dialyzable materials of cranberry extract in poultry production. | studies on effects of cranberry products in animals, especially in chickens, are very scarce or even lacking. this study investigated the immunomodulatory effect of high molecular weight non-dialyzable materials (ndms) of cranberry extract. the in vitro antioxidant and anti-inflammatory activities were investigated. the ability of ndms (0, 1, 2, or 4 mg/ml) to enhance phagocytic activities was also evaluated using chicken heterophils (ches) against staphylococcus aureus furthermore, a broiler mo ... | 2017 | 27587728 |
| rapid and sensitive detection of mycoplasma synoviae by an insulated isothermal polymerase chain reaction-based assay on a field-deployable device. | mycoplasma synoviae (ms), causing respiratory diseases, arthritis, and eggshell apex abnormalities in avian species, is an important pathogen in the poultry industry. implementation of a biosecurity plan is important in ms infection management. working on a field-deployable pockit™ device, an insulated isothermal polymerase chain reaction (iipcr) assay has a potential for timely ms detection on the farm. the ms iipcr assay had limit of detection 95% of about 9 genome equivalents by testing seria ... | 2017 | 27389062 |
| design, synthesis and antimicrobial activities of thiouracil derivatives containing triazolo-thiadiazole as seca inhibitors. | a series of novel thiouracil derivatives containing a triazolo-thiadiazole moiety (7a-7l) have been synthesized by structural modifications on a lead seca inhibitor, 2. all the compounds have been evaluated for their antibacterial activities against bacillus amyloliquefaciens, staphylococcus aureus, and bacillus subtilis. compounds 7d and 7g were also tested for their inhibitory activities against seca atpase due to their promising antimicrobial activities. the inhibitory activity of compound 7d ... | 2017 | 28039774 |
| aspergillus terreus brain abscess complicated by tension pneumocephalus in a patient with angiosarcoma. | background aspergillus terreus is an evolving opportunistic pathogen, and patients with a. terreus often have poor outcomes due to its intrinsic resistance to several systemic antifungal agents. here we present a unique case of intracranial abscesses of a. terreus in a patient with recurrent angiosarcoma, complicated by development of tension pneumocephalus. case report a 67-year old gentleman with history of scalp angiosarcoma with wide excision two years prior presented to the hospital for lef ... | 2017 | 28070116 |
| isolation and identification of phase i metabolites of butyrolactone i in rats. | 1. butyrolactone i (bl-i), one of the major secondary metabolites of fungus aspergillus terreus, is a selective cdc2 kinase inhibitor. in the present study, the metabolism of bl-i in male wistar rats was investigated by characterizing metabolites excreted into feces. 2. following an oral dose of 40 mg/kg bl-i, 10 phase i metabolites were isolated from the feces of rats, and their structures were identified on the basis of a range of spectroscopic data and icd analysis. these metabolites were ful ... | 2017 | 27604497 |
| evaluating bionanoparticle infused fungal metabolites as a novel antimicrobial agent. | therapeutic properties of fungal metabolites and silver nanoparticles have been well documented. while fungal metabolites have been used for centuries as medicinal drugs, potential of biogenic silver nanoparticles has recently received attention. we have evaluated the antimicrobial potential of aspergillus terreus crude extract, silver nanoparticles and an amalgamation of both against four pathogenic bacterial strains. antimicrobial activity of the following was evaluated - a. terreus extract, b ... | 2017 | 27429931 |
| synthesis, antifungal and antibacterial activity of novel 1,2,4-triazole derivatives. | a large number of 1,2,4-triazole-containing ring system have been incorporated into a wide variety of therapeutically interesting drug candidates including anti-inflammatory, central nervous system stimulants, antianxiety, and antimicrobial agents. to overcome the rapid development of drug resistance, new agents should preferably have chemical characteristics that clearly differ from those of existing agents. thus led to the design and synthesize the new antimicrobial agents. a novel series of s ... | 2017 | 26317080 |
| chemical composition and biological activities of the essential oil from rubus pungens var. oldhamii. | this paper presents a study on chemical composition, antimicrobial, antioxidant and tyrosinase inhibitory properties of the essential oil from leaves of rubus pungens var. oldhamii (reo). the major component of the reo is sesquiterpenes (36.04%), which consists of 1,5-cyclooctadiene,3-(1-me thylallyl)-(8ci)(17.66%), 5,6-diethenyl-1-methylcyclohexene (12%), (+) - γ-elemene (10.48%) and β-caryophyllene (8.39%).the reo is shown to be moderately active against staphylococcus aureus, aspergillus nige ... | 2017 | 27817203 |
| development of antibacterial conjugates using sulfamethoxazole with monocyclic terpenes: a systematic medicinal chemistry based computational approach. | to develop 6 conjugate agents of the moribund antibiotic sulfamethoxazole (smz) joined to 6 individual monoterpenes, followed by protocols of medicinal chemistry as potent antibacterials, against multidrug resistant (mdr) human gruesome pathogenic bacteria. | 2017 | 28254074 |