Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| innovative non-thermal plasma disinfection process inside sealed bags: assessment of bactericidal and sporicidal effectiveness in regard to current sterilization norms. | in this work, we developed a device capable to generate a non-thermal plasma discharge inside a sealed bag. the aim of this study was to assess the effectiveness of the oxygen, nitrogen and argon plasma sterilization on pseudomonas aeruginosa, staphylococcus aureus and bacillus subtilis spores according to the nf en 556 norm. moreover the bag integrity which is a critical key to maintain the sterile state of items after the end of the process was verified by fourier transform infrared (ftir) and ... | 2017 | 28662202 |
| fluoro-carba-sugars are glycomimetic activators of the glms ribozyme. | the glms ribozyme is a bacterial gene-regulating riboswitch that controls cell wall synthesis, depending on glucosamine-6-phosphate as a cofactor. due to the presence of this ribozyme in several human pathogen bacteria (e.g. mrsa, vrsa), the glms ribozyme represents an attractive target for the development of artificial cofactors. the substitution of the ring oxygen in carbohydrates by functionalized methylene groups leads to a new generation of glycomimetics that exploits distinct interaction p ... | 2017 | 28661578 |
| identification and growth optimization of a marine bacillus dk1-sa11 having potential of producing broad spectrum antimicrobial compounds. | control of harmful bacteria in food, aquaculture, pharmaceuticals, agriculture, hospitals and recreation water pools are of great global concern. marine bacteria are an enormous source of bio-controlling agents. the aim of this study was to identify and optimize the growth conditions including effect of different biotic and abiotic factors on antimicrobial activity of strain dk1-sa11 isolated from qingdao bay of china yellow sea. microscopic characterization, api® 20e and 50 chb kit base carbohy ... | 2017 | 28653930 |
| screening of leaves extracts from calamus aromaticus for their antimicrobial activity by disc diffusion assay. | the current research investigates the anti-microbial activities of different solvent extracted samples from the leaves of calamus aromaticus against gram positive, gram negative bacteria and fungi using 500, 1000 and 2000 μg disc(-1) concentrations. escherichia coli, citorbacter freundii and candida albicans showed resistivity to crude methanolic extract and the same microbes were more susceptible to water extracted fractions. maximum activity was measured by hexane extracted fractions against p ... | 2017 | 28653924 |
| kitchen phytochemicals from allium cepa - their role in multidrug resistance. | bacterial resistance to antibiotics is increasingly becoming a concern to public health. current antibiotics have failed to bring desirable results to many bacterial infections due to multi-resistant strains. so, concerted efforts are being made to curve this with the help of dietary phytohemicals. a number of dietary phytochemical are being put to trials for antimicrobial activity; however it is worthwhile to search such a part of diet that is very frequently used by major population. keeping t ... | 2017 | 28653923 |
| evaluation of anti-oxidative, antimicrobial and anti-diabetic potential of adiantum venustum and identification of its phytochemicals through gc-ms. | the present study aimed to explore antioxidant, antimicrobial and anti-diabetic properties of the fern adiantum venustum. the tpc (total phenolic content) of methanolic extract of the plant was 247.95±0.0007μg of gallic acid equivalents per gram of dried extract (mg gae/g). the highest tpc was in n-butanolic fraction, which was 981.45±0.1562mg gae/g. hexane fraction showed lowest tpc (256.95±0.0420mg gae/g). ethyl acetate fraction exhibited highest total flavonoid content (tfc), i.e., 62.0±0.050 ... | 2017 | 28653913 |
| 1,1ꞌ-carbonyldiimidazole (cdi) mediated facile synthesis, structural characterization, antimicrobial activity and in-silico studies of coumarin-3-carboxamide derivatives. | despite of the availability of variety of antibacterial agents, re-emergance of pathogenic bacteria is still a serious medical concern. so, identification of new, safer, and selective antibacterial agents is the key interest in the medicinal chemistry research. | 2017 | 28641525 |
| chemical composition and biological activities of leaf and fruit essential oils from eucalyptus camaldulensis. | the chemical composition of the essential oils from the leaves and fruit of eucalyptus camaldulensis grown in mersin, turkey was analyzed using gas chromatography (gc) and gas chromatography-mass spectrometry (gc-ms) techniques. the biological activities (antibacterial and antifungal) were examined using the agar well diffusion method. the main leaf oil constituents were p-cymene (42.1%), eucalyptol (1,8-cineole) (14.1%), α-pinene (12.7%) and α-terpinol (10.7%). the main constituents of the frui ... | 2017 | 28640755 |
| coumarin-benzimidazole hybrids as a potent antimicrobial agent: synthesis and biological elevation. | molecular hybridization approach is an emerging tool in drug discovery for designing new pharmacophores with biological activity. a novel, new series of coumarin-benzimidazole hybrids were designed, synthesized and evaluated for their broad spectrum antimicrobial activity. among all the synthesized molecules, compound (e)-3-(2-1h-benzo[d]imidazol-1-yl)-1-((4-chlorobenzyl)oxy)imino)ethyl)-2h-chromen-2-one showed the most promising broad spectrum antibacterial activity against pseudomonas aerugino ... | 2017 | 28634338 |
| antibacterial and antifungal activities of spices. | infectious diseases caused by pathogens and food poisoning caused by spoilage microorganisms are threatening human health all over the world. the efficacies of some antimicrobial agents, which are currently used to extend shelf-life and increase the safety of food products in food industry and to inhibit disease-causing microorganisms in medicine, have been weakened by microbial resistance. therefore, new antimicrobial agents that could overcome this resistance need to be discovered. many spices ... | 2017 | 28621716 |
| synthesis of new thiazolyl coupled pyrazoles bearing 2,4-thiazolidinedionyl pharmacophore and their anti-inflammatory and antibacterial evaluation. | 2, 4-thiazolidinedione (tzd), pyrazole and thiazole heterocyclic rings exhibit wide range of pharmacological activities. medicinal chemists use these heterocyclic moieties as scaffolds in drug designing and discovery. the existing medicaments, celecoxib and meloxicam, used for treating inflammation and pain are having, pyrazole and thiazole, respectively as a key scaffolds. pyrazoles coupled with 2, 4-thiazolidinediones may display enhanced anti inflammatory activity. with this hope the title wo ... | 2017 | 28618987 |
| molecular cloning and analysis of a c-type lectin from silkworm bombyx mori. | c-type lectins (ctls) play a variety of roles in plants and animals. they are involved in animal development, pathogen recognition, and the activation of immune responses. ctls carry one or more non-catalytic carbohydrate-recognition domains (crds) to bind specific carbohydrates reversibly. here, we report the molecular cloning and functional analysis of a single-crd ctl, named c-type lectin-s2 (bmctl-s2) from the domesticated silkmoth bombyx mori (lepidoptera: bombycidae). the orf of ctl-s2 is ... | 2017 | 28618068 |
| the structural assembly switch of cell division protein ftsz probed with fluorescent allosteric inhibitors. | ftsz is a widely conserved tubulin-like gtpase that directs bacterial cell division and a new target for antibiotic discovery. this protein assembly machine cooperatively polymerizes forming single-stranded filaments, by means of self-switching between inactive and actively associating monomer conformations. the structural switch mechanism was proposed to involve a movement of the c-terminal and n-terminal ftsz domains, opening a cleft between them, allosterically coupled to the formation of a t ... | 2017 | 28616148 |
| cytotoxic and antimicrobial activities of cantharellus cibarius fr. (cantarellaceae). | antibacterial and cytotoxic activities of cyclohexane, dichloromethane, methanol, and aqueous extracts of cantharellus cibarius were tested. broth microdilution assay was performed against 10 bacterial strains (staphylococcus aureus, s. epidermidis, micrococcus luteus, bacillus subtilis, enterococcus feacalis, escherichia coli, klebsiella pneumoniae, pseudomonas aeruginosa, salmonella abony), with emphasis on helicobacter pylori. methanol extract was the most active against h. pylori strains wit ... | 2017 | 28613963 |
| microcontact imprinted plasmonic nanosensors: powerful tools in the detection of salmonella paratyphi. | identification of pathogenic microorganisms by traditional methods is slow and cumbersome. therefore, the focus today is on developing new and quicker analytical methods. in this study, a surface plasmon resonance (spr) sensor with a microcontact imprinted sensor chip was developed for detecting salmonella paratyphi. for this purpose, the stamps of the target microorganism were prepared and then, microcontact s. paratyphi-imprinted spr chips were prepared with the functional monomer n-methacrylo ... | 2017 | 28608810 |
| enzyme inhibitory, antifungal, antibacterial and hemolytic potential of various fractions of colebrookia oppositifolia. | the purpose of the present investigation was to assess the enzyme inhibition, antifungal, antibacterial and hemolytic activities of various fractions of colebrookia oppositifolia smith. the meoh extract of plant was dissolved in dist. water and partitioned with n-hexane, chcl3, etoac and n-buoh sequentially. enzyme inhibition studies were done against four enzymes i.e. α-glucosidase, butyrylcholinesterase, acetyl cholinesterase and lipoxygenase. ethyl acetate fraction possessed very good activit ... | 2017 | 28603120 |
| a truncated sph12-38 with potent antimicrobial activity showing resistance against bacterial challenge in oryzias melastigma. | antimicrobial peptides (amps) represent an efficient part of innate immunity and are found in a variety of life. among them histone 2a (h2a), as a promising class of amps, attracts great attention, but the in vivo mechanism of h2a derived amp is still less known. based on the acquisition of sphistin, a synthetic 38-amino acid h2a derived peptide from scylla paramamosain, as reported in our previous study, was truncated into three short fragments (sph12-38, sph20-38 and sph30-38) and further inve ... | 2017 | 28600196 |
| antimicrobial effect of okcel® h-d prepared from oxidized cellulose. | the antimicrobial effect of okcel® h-d, a topical, absorbable hemostatic textile prepared from oxidized cellulose, was tested. testing by dilution and diffusion methods was conducted on a spectrum of 27 select microorganisms, including also antibiotic-resistant strains. okcel® h-d showed inhibitory effects on nearly all tested bacteria. in testing using the dilution suspension method, the majority of bacteria showed decrease in cell density by 7-8 orders of magnitude after just 6 h of exposure. ... | 2017 | 28597345 |
| antibacterial and anticancer activities of acetone extracts from in vitro cultured lichen-forming fungi. | lichens that were used in traditional medicine for ages produce numerous secondary metabolites, however our knowledge about biological activities of substances secreted by separated bionts is scarce. the main objectives of this study were to isolate and find optimal conditions for the growth of mycelia from three common lichen-forming fungi, i.e. caloplaca pusilla, protoparmeliopsis muralis and xanthoria parietina and to evaluate antibacterial and antiproliferative activities of their acetone ex ... | 2017 | 28592323 |
| investigation into the antimicrobial action and mechanism of a novel endogenous peptide β-casein 197 from human milk. | a novel endogenous peptide cleaved from 197-213 aa of β-casein, named β-casein 197, was identified by tandem mass spectrometry. β-casein 197 constituted a significant proportion of the peptide content in preterm milk. this study investigated the antibacterial effects and mechanisms against common pathogenic bacteria. six bacterial strains were selected for this study: escherichia coli, staphylococcus aureus, yersinia enterocolitica, listeria monocytogenes, klebsiella pneumonia and bacillus subti ... | 2017 | 28591979 |
| evaluation of phenolic profile and antibacterial bioactivities of nigella sativa l. seed extracts. | black cumin (nigella sativa l. [n. sativa]) seed extracts demonstrated numerous beneficial biological effects including, among others, antidiabetic, anticancer, immunomodulatory, antimicrobial, anti-inflammatory, antihypertensive, and antioxidant activity. to better understand the phytochemical composition of n. sativa seeds, methanol seed extracts were analyzed for phenolic acid and flavonoid content. furthermore, we tested n. sativa methanol, n-hexane, and aqueous seed extracts for their inhib ... | 2017 | 28590231 |
| production of macrolide antibiotics from a cytotoxic soil streptomyces sp. strain zdb. | crude extract from a culture of a soil streptomyces sp. strain zdb showed toxicity towards artemia salina and antimicrobial activity against escherichia coli, bacillus subtilis, staphylococcus aureus, chlorella vulgaris, and chlorella sorokiniana. large scale fermentation of the strain led to the isolation of the macrolide antibiotics, bafilomycins a1 (1), b1 (2), and d (3) together with nonactic acid (4) and bostrycoidin-9-methyl ether (5). structures of the antibiotics were determined based on ... | 2017 | 28585168 |
| in vitro antibacterial activity of poly (amidoamine)-g7 dendrimer. | nano-scale dendrimers are synthetic macromolecules that frequently used in medical and health field. traditional anibiotics are induce bacterial resistence so there is an urgent need for novel antibacterial drug invention. in the present study seventh generation poly (amidoamine) (pamam-g7) dendrimer was synthesized and its antibacterial activities were evaluated against representative gram- negative and gram-positive bacteria. | 2017 | 28583153 |
| antimicrobial peptide from bacillus subtilis csb138: characterization, killing kinetics, and synergistic potency. | we studied the prospect of synergy between the antimicrobial peptide p138c and non-peptide antibiotics for increasing the potency and bacterial killing kinetics of these agents. the production of p138c was maximized in the late exponential growth phase of bacillus subtilis csb138. purification of p138c resulted in a total of 4800 arbitrary units (au) with 19.15-fold and 3.2% recovery. peptide p138c was thermo-tolerant up to 50 °c and stable at ph 5.8 to 11. the biochemical nature of p138c was de ... | 2017 | 28581021 |
| new phenalenone derivatives from pinellia ternata tubers derived aspergillus sp. | nine new phenalenone derivatives (1-9), along with two known analogues (10-11) have been isolated from the solid cultures of an endophytic fungus aspergillus sp. which was obtained from pinellia ternate. their structures were established through interpretations of spectroscopic evidence, and some of their absolute configurations were determined by electronic circular dichroism (ecd) and mo2(ococh3)4 induced ecd. all of the phenalenones are unusual acyclic diterpenoid adducts, which are diversely ... | 2017 | 28577908 |
| antibacterial and antioxidant potential of stem bark extract of bombax ceiba collected locally from south punjab area of pakistan. | ethnic medication systems have been used extensively by humans since their origin. now a day, in the developing countries these systems are being used due to their effectiveness and affordability. especially inhabitants of rural areas still rely on these systems as first line of treatment against diseased conditions. till now, majority of medicines is derived from the natural origin particularly plants owing to their little side effects and cost effectiveness. | 2017 | 28573217 |
| new merosesquiterpenes from a vietnamese marine sponge of spongia sp. and their biological activities. | the investigation of the vietnamese marine sponge spongia sp. led to the isolation of three new sesquiterpene phenols, langconols a-c (1-3), and one new sesquiterpene hydroxyquinone, langcoquinone c (4), together with two known meroterpenoids (5 and 6). their structures were determined on the basis of spectroscopic analyses and comparisons with published data. furthermore, the antibacterial assays of the isolates 1-6 suggested that 4 and 6 had significant antibacterial activities against bacillu ... | 2017 | 28558970 |
| staphylococcal botryomycosis of the glans penis. | a middle aged male had botryomycosis affecting the glans penis. there were macroscopic granules that on gram staining showed masses of staphylococci.staphylococcus aureus was isolated from the lesion. there was prompt response to surgical removal of the affected tissue in conjunction with systemic cloxacillin. | 2017 | 28134219 |
| use of benzathine pencillin in impectigo in children. | one hundred and fifty children having impetigo were investigated bacteriologically. pure growth of staphylococcus aureus was found in 92 children, streptococcus pyogenes in 39 children and both organisms were isolated in 19 children. forty four per cent staphylococcus aureus and 82% streptococcus pyogenes were sensitive to penicillin. one hundred children were treated with injection benzathine penicillin and fifty cases treated with oral tablet sulfamoxole. benzathine pencillin was effective in ... | 2017 | 28145347 |
| update on infections in articular prosthesis. | the implantation of joint prostheses, especially for the hip and knee, is becoming increasingly common. this provides a significant reduction in discomfort and an immeasurable improvement in patient mobility. reviews of the worldwide literature indicate that 1 to 5% of these prostheses become infected, although it is important to remember that as the number of operations performed to implant these prosthesis increases, so will the number of cases of this type of infection. gram-positive bacteria ... | 2017 | 27026957 |
| lacrimal function and ocular complications in patients treated with systemic isotretinoin. | to evaluate the effect on lacrimal function and ocular complications in patients with severe acne vulgaris during systemic treatment with 13- cis-retinoic acid (isotretinoin). | 2017 | 28226159 |
| mrsa-free elective orthopaedic surgery.a dedicated elective orthopaedic ward free from mrsa alexandra hospital, redditch, uk. | deep infection complicating arthroplasty surgery carries a heavy financial and emotional burden on any orthopaedic service. the cost of hospital acquired infection is estimated at 1 billion per year by the national audit office. healthcare associated infection is an area currently under great scrutiny. the alexandra hospital, redditch, has developed a dedicated elective orthopaedic ward free from methicillin-resistant staphylococcus aureus (mrsa) that delivers high quality and high volume major ... | 2017 | 28224603 |
| open drainage versus percutaneous drainage in the treatment of tropical pyomyositis. prospective and randomized study. | to compare the results from treating tropical pyomyositis through percutaneous drainage of abscesses versus open surgical drainage of abscesses, by means of a randomized prospective study. | 2017 | 27022550 |
| differential effects of planktonic and biofilm mrsa on human fibroblasts. | bacteria colonizing chronic wounds often exist as biofilms, yet their role in chronic wound pathogenesis remains unclear. staphylococcus aureus biofilms induce apoptosis in dermal keratinocytes, and given that chronic wound biofilms also colonize dermal tissue, it is important to investigate the effects of bacterial biofilms on dermal fibroblasts. the effects of a predominant wound pathogen, methicillin-resistant s. aureus, on normal, human, dermal fibroblasts were examined in vitro. cell-cultur ... | 2017 | 22332802 |
| simultaneous antibiofilm and antiviral activities of an engineered antimicrobial peptide during virus-bacterium coinfection. | antimicrobial-resistant infections are an urgent public health threat, and development of novel antimicrobial therapies has been painstakingly slow. polymicrobial infections are increasingly recognized as a significant source of severe disease and also contribute to reduced susceptibility to antimicrobials. chronic infections also are characterized by their ability to resist clearance, which is commonly linked to the development of biofilms that are notorious for antimicrobial resistance. the us ... | 2017 | 27303744 |
| effect of human burn wound exudate on pseudomonas aeruginosa virulence. | burn wound sepsis is currently the main cause of morbidity and mortality after burn trauma. infections by notorious pathogens such as pseudomonas aeruginosa, staphylococcus aureus, and acinetobacter baumannii impair patient recovery and can even lead to fatality. in this study, we investigated the effect of burn wound exudates (bwes) on the virulence of those pathogens. bwes were collected within 7 days after burn trauma from 5 burn patients. we first monitored their effect on pathogen growth. i ... | 2017 | 27303724 |
| cathodic voltage-controlled electrical stimulation of titanium for prevention of methicillin-resistant staphylococcus aureus and acinetobacter baumannii biofilm infections. | antibiotic resistance of bacterial biofilms limits available treatment methods for implant-associated orthopaedic infections. this study evaluated the effects of applying cathodic voltage-controlled electrical stimulations (cvces) of -1.5v and -1.8v (vs. ag/agcl) to coupons of commercially pure titanium (cpti) incubated in cultures of methicillin-resistant staphylococcus aureus (mrsa) and acinetobacter baumannii (a. baumannii) as a method of preventing bacterial attachment. stimulations were app ... | 2017 | 27890730 |
| detection of eskape bacterial pathogens at the point of care using isothermal dna-based assays in a portable degas-actuated microfluidic diagnostic assay platform. | an estimated 1.5 billion microbial infections occur globally each year and result in ∼4.6 million deaths. a technology gap associated with commercially available diagnostic tests in remote and underdeveloped regions prevents timely pathogen identification for effective antibiotic chemotherapies for infected patients. the result is a trial-and-error approach that is limited in effectiveness, increases risk for patients while contributing to antimicrobial drug resistance, and reduces the lifetime ... | 2017 | 27986722 |
| refugees and antimicrobial resistance: a systematic review. | there is a large increase in the numbers of refugees and asylum seekers worldwide and a lack of data on the carriage of antimicrobial resistance in refugee/asylum seeking groups. | 2017 | 27919742 |
| a study of pre-operative presence of micro-organisms in affected knee joints of rheumatoid arthritis patients who need total knee arthroplasty. | to evaluate, by way of intraoperative tissue culture and pathological study, the pre-operative presence of micro-organisms in knee joints of patients with rheumatoid arthritis (ra) who need total knee arthroplasty (tka). | 2017 | 27919672 |
| universal contact precautions do not change the prevalence of antibiotic resistant organisms in a tertiary burn unit. | the prevalence of antibiotic-resistant organisms (aro) in burn units is increasing worldwide and contributes significantly to morbidity and mortality. study aims are to describe the burden of aros in burn patients admitted to a tertiary burn unit, to evaluate the impact of contact precautions implemented after an outbreak of antibiotic-resistant acinetobacter baumannii, and to identify possible predictors of aro acquisition. | 2017 | 27915096 |
| synthesis and antimicrobial studies of novel derivatives of 4-(4-formyl-3-phenyl-1h-pyrazol-1-yl)benzoic acid as potent anti-acinetobacter baumannii agents. | microbial resistance to antibiotics is a global concern. the world health organization (who) has identified antimicrobial resistance as one the three greatest threats for human beings in the 21st century. without urgent and coordinated action, the world is moving toward a post-antibiotic era, in which normal infections or minor injuries may become fatal. in an effort to find new agents, we report the synthesis and antimicrobial activities of 40 novel 1,3-diphenyl pyrazole derivatives. these comp ... | 2017 | 28065568 |
| epidemiology and control measures of outbreaks due to antibiotic-resistant organisms in europe (embargo): a systematic review protocol. | improving our understanding of outbreaks due to antibiotic-resistant bacteria (arb) and their control is critical in the current public health scenario. the threat of outbreaks due to arb requires multifaceted efforts. however, a global overview of epidemiological characteristics of outbreaks due to arb and effective infection control measures is missing. in this paper, we describe the protocol of a systematic review aimed at mapping and characterising the epidemiological aspects of outbreaks du ... | 2017 | 28057656 |
| manual resuscitators in successive use in the same patient: reservoir of multi- and extensively resistant bacteria. | to determine the bacterial load on manual resuscitators (mrs), swab samples of mr connectors from a brazilian intensive care unit were collected at time zero, and after 24 and 48h use in the same patient. from 20 mrs, a total of 54 bacteria were isolated: six at t=0, 17 at t=24, and 31 at t=48. staphylococcus aureus, acinetobacter baumannii, serratia marcescens, and pseudomonas aeruginosa were the predominant isolates, and multidrug resistance was widespread in all species. greater awareness of ... | 2017 | 28012582 |
| infectious disease exposures and outbreaks at a south african neonatal unit with review of neonatal outbreak epidemiology in africa. | hospitalized neonates are vulnerable to infection, with pathogen exposures occurring in utero, intrapartum, and postnatally. african neonatal units are at high risk of outbreaks owing to overcrowding, understaffing, and shared equipment. | 2017 | 28161461 |
| the antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis. | aditoprim (adp) has potential use as an antimicrobial agent in animals. however, its pharmacodynamic properties have not been systematically studied yet. in this study, the in vitro antibacterial activities of adp and its main metabolites were assayed, and the in vivo antibacterial efficacy of adp for the treatment of swine streptococcosis was evaluated. it was shown that salmonella and streptococcus from swine, escherichia coli and salmonella from chickens, e. coli, streptococcus, mannheimia, p ... | 2017 | 28145487 |
| evaluation of antimicrobial persistent activity of alcohol-based hand antiseptics against bacterial contamination. | the purpose of this study was to evaluate persistent activity of three alcohol-based antiseptics widely used in the clinical routine containing chlorhexidine, triclosan or mecetronium after hand disinfection. four tests were used to evaluate the antimicrobial activity of antiseptics on: (i) resident microbiota; (ii) nutrient agar plates (nap) subsequently inoculated with a test organism; and transient microbiota acquired by contact with dry hands (iii), or (iv) a wet inert surface that had been ... | 2017 | 28132117 |
| the role of universal stress proteins in bacterial infections. | universal stress proteins are ubiquitously expressed in bacteria, archaea and plants and other eukaryotes. a general property of usps is their role in adaptation of bacteria to oxidative stress, high temperature, low ph and/or hypoxia. there is increasing evidence that these proteins facilitate the adaption of bacterial pathogens to the human host environment, thereby facilitating colonisation and pathogenicity. usps in mycobacterium tuberculosis are well studied and may play a role in latency o ... | 2017 | 28120710 |
| nitroxoline: a broad-spectrum biofilm-eradicating agent against pathogenic bacteria. | bacterial biofilms are surface-attached communities of slow-growing or non-replicating bacteria tolerant to conventional antibiotic therapies. although biofilms are known to occur in ca. 80% of all bacterial infections, no therapeutic agent has been developed to eradicate bacteria housed within biofilms. we have discovered that nitroxoline, an antibacterial agent used to treat urinary tract infections, displays broad-spectrum biofilm-eradicating activities against major human pathogens, includin ... | 2017 | 28110918 |
| biofilm formation of achromobacter xylosoxidans on contact lens. | achromobacter spp. may contaminate lenses, lens cases, and contact lens solutions and cause ocular infections. the aim of this study was to investigate the possibility of isolated strain of achromobacter xylosoxidans to form biofilm on the surface of soft contact lenses (cl), to quantify the production of the formed biofilm, and compare it with the reference strains (pseudomonas aeruginosa, staphylococcus aureus, and haemophilus influenzae). bacterial strain isolated from one contact lens case w ... | 2017 | 28218002 |
| achromobacter xylosoxidans infection in cystic fibrosis siblings with different outcomes: case reports. | the clinical relevance of achromobacter xylosoxidans infection in cystic fibrosis (cf) remains controversial. this emerging agent in cf has been associated with increased lung inflammation, more frequent exacerbations and more severe lung disease. we describe a pair of cf siblings chronically colonized by the same multilocus genotype of a. xylosoxidans with different clinical courses, and assess whether this species may have developed any virulence traits and antimicrobial resistance that could ... | 2017 | 28138423 |
| interaction between methicillin-resistant staphylococcus aureus (mrsa) and acanthamoeba polyphaga. | the interactions that occur between bacteria and amoebae can give through mutual relations, where both organisms benefit from the association or parasitic in which one organism benefits at the expense of the other. when these organisms share the same environment, it can result in some changes in the growth of organisms, in adaptation patterns, in morphology, development or even in their ability to synthesize proteins and other substances. in this study, the interaction between acanthamoeba polyp ... | 2017 | 28258293 |
| role of pathogens in multiple sclerosis. | multiple sclerosis (ms) is an inflammatory demyelinating autoimmune disease of the central nervous system (cns). although the etiology of ms is unknown, genetic and environmental factors play a role. infectious pathogens are the likely environmental factors involved in the development of ms. pathogens associated with the development or exacerbation of ms include bacteria, such as mycoplasma pneumoniae and chlamydia pneumoniae, the staphylococcus aureus-produced enterotoxins that function as supe ... | 2017 | 24266364 |
| the ability of a colloidal silver gel wound dressing to kill bacteria in vitro and in vivo. | inhibiting bacterial biofilms is of major significance for proper wound healing. the choice of the dressing material plays a key role, as bacteria can live in dressings and keep reinfecting the wound. this study examines the effectiveness of a colloidal silver gel (ag-gel) wound dressing in inhibiting the growth of bacteria in a mouse wound model. | 2017 | 28379105 |
| interplay between antibiotic resistance and virulence during disease promoted by multidrug-resistant bacteria. | diseases caused by antibiotic-resistant bacteria in hospitals are the outcome of complex relationships between several dynamic factors, including bacterial pathogenicity, the fitness costs of resistance in the human host, and selective forces resulting from interventions such as antibiotic therapy. the emergence and fate of mutations that drive antibiotic resistance are governed by these interactions. in this review, we will examine how different forms of antibiotic resistance modulate bacterial ... | 2017 | 28375515 |
| structural modification of lipopolysaccharide conferred by mcr-1 in gram-negative eskape pathogens. | mcr-1 was initially reported as the first plasmid-mediated colistin resistance gene in clinical isolates of escherichia coli and klebsiella pneumoniae in china and has subsequently been identified worldwide in various species of the family enterobacteriaceae. mcr-1 encodes a phosphoethanolamine transferase and its expression has been shown to generate phosphoethanolamine-modified bis-phosphorylated hexa-acylated lipid a in e. coli here, we investigated the effect of mcr-1 on colistin susceptibil ... | 2017 | 28373195 |
| presence of multidrug-resistant organisms in the residents and environments of long-term care facilities in taiwan. | this study investigated the prevalence of multidrug-resistant organisms (mdros) in the residents and environments of long-term care facilities (ltcfs) in taiwan. | 2017 | 28373038 |
| factors associated with recurrent bacterial empyema thoracis. | empyema thoracis (et) is one of the common thoracic diseases frequently found in developing countries. in the past, only a few studies have analyzed recurrent et, and none had clearly identified the prognostic factors for recurrence. the aim of this study is to identify the prognostic factors of recurrent et in northern thailand. | 2017 | 28372933 |
| synergistic effects of antimicrobial peptide dp7 combined with antibiotics against multidrug-resistant bacteria. | antibiotic-resistant bacteria present a great threat to public health. in this study, the synergistic effects of antimicrobial peptides (amps) and antibiotics on several multidrug-resistant bacterial strains were studied, and their synergistic effects on azithromycin (azt)-resistance genes were analyzed to determine the relationships between antimicrobial resistance and these synergistic effects. a checkerboard method was used to evaluate the synergistic effects of amps (dp7 and cls001) and seve ... | 2017 | 28356719 |
| n6', n6''', and o4' modifications to neomycin affect ribosomal selectivity without compromising antibacterial activity. | the synthesis of a series of neomycin derivatives carrying the 2-hydroxyethyl substituent on n6' and/or n6‴ both alone and in combination with a 4'-o-ethyl group is described. by means of cell-free translation assays with wild-type bacterial ribosomes and their hybrids with eukaryotic decoding a sites, we investigate how individual substituents and their combinations affect activity and selectivity at the target level. in principle, and as shown by cell-free translation assays, modifications of ... | 2017 | 28343384 |
| evaluating the effect of peptoid lipophilicity on antimicrobial potency, cytotoxicity, and combinatorial library design. | growing prevalence of antibiotic resistant bacterial infections necessitates novel antimicrobials, which could be rapidly identified from combinatorial libraries. we report the use of the peptoid library agar diffusion (plad) assay to screen peptoid libraries against the eskape pathogens, including the optimization of assay conditions for each pathogen. work presented here focuses on the tailoring of combinatorial peptoid library design through a detailed study of how peptoid lipophilicity relat ... | 2017 | 28291947 |
| characterizing the antimicrobial activity of n(2), n(4) -disubstituted quinazoline-2,4-diamines towards multidrug resistant acinetobacter baumannii. | we previously reported a series of n(2) ,n(4) -disubstituted quinazoline-2,4-diamine as dihydrofolate reductase inhibitors, with potent in vitro and in vivo antibacterial activity against mrsa strains. in this work we extend our previous study to the gram-negative pathogen acinetobacter baumannii we determined that optimized n(2) ,n(4) -disubstituted quinazoline-2,4-diamines are strongly antibacterial against multi-drug resistant a. baumannii strains when the 6-position is substituted with a hal ... | 2017 | 28289036 |
| persistent nasal carriers of acinetobacter baumannii in long-term-care facilities. | acinetobacter baumannii and staphylococcus aureus have persisted as 2 major pathogens worldwide. | 2017 | 28284750 |
| natural antimicrobial peptide complexes in the fighting of antibiotic resistant biofilms: calliphora vicina medicinal maggots. | biofilms, sedimented microbial communities embedded in a biopolymer matrix cause vast majority of human bacterial infections and many severe complications such as chronic inflammatory diseases and cancer. biofilms' resistance to the host immunity and antibiotics makes this kind of infection particularly intractable. antimicrobial peptides (amps) are a ubiquitous facet of innate immunity in animals. however, amps activity was studied mainly on planktonic bacteria and little is known about their e ... | 2017 | 28278280 |
| fluorescence high-throughput screening for inhibitors of tonb action. | gram (-) bacteria acquire ferric siderophores through tonb-dependent outer membrane transporters (tbdt). by fluorescence spectroscopic high-throughput screening (flhts) we identified inhibitors of tonb-dependent ferric enterobactin (feent) uptake through e. coli fepa (ecofepa). among 165 inhibitors found in a primary screen of 17,441 compounds, we evaluated 20 in secondary tests: tonb-dependent ferric siderophore uptake and colicin killing; proton-motive force-dependent lactose transport. 6 of 2 ... | 2017 | 28242720 |
| mechanical ventilator as a major cause of infection and drug resistance in intensive care unit. | ventilator-associated pneumonia (vap) is the most frequent infection in intensive care units (icu). it is associated with high rates of long morbidity and mortality. management of a case of vap is often said to add $40,000 to hospital costs usa. all these data directed our interest to study the etiology, risk factors, and antibiotic susceptibility patterns of vap in icu of tanta university hospital. this study included 36 cases of vap. endotracheal aspirates were obtained from all cases and micr ... | 2017 | 28233206 |
| increasing resistance to extended-spectrum cephalosporins, fluoroquinolone, and carbapenem in gram-negative bacilli and the emergence of carbapenem non-susceptibility in klebsiella pneumoniae: analysis of korean antimicrobial resistance monitoring system (karms) data from 2013 to 2015. | national surveillance of antimicrobial resistance becomes more important for the control of antimicrobial resistance and determination of treatment guidelines. we analyzed korean antimicrobial resistance monitoring system (karms) data collected from 2013 to 2015. | 2017 | 28224769 |
| can contaminated water be rendered safe for nasal saline irrigations? | to compare sterile water to three methods of sterilization (carbon filtration, boiling, and ultraviolet [uv] light) for preparation of nasal saline irrigants free of bacterial and amebic contaminants. | 2017 | 28224696 |
| novel bacterial topoisomerase inhibitors with potent broad-spectrum activity against drug-resistant bacteria. | the novel bacterial topoisomerase inhibitor class is an investigational type of antibacterial inhibitor of dna gyrase and topoisomerase iv that do not have cross-resistance with the quinolones. here, we report the evaluation of the in vitro properties of a new series of this type of small molecules. exemplar compounds selectively and potently inhibited the catalytic activities of escherichia coli dna gyrase and topoisomerase iv but did not block the dna breakage-reunion step. compounds showed br ... | 2017 | 28223393 |
| [significance of bacteria detection with filter paper method on diagnosis of diabetic foot wound infection]. | objective: to evaluate the significance of bacteria detection with filter paper method on diagnosis of diabetic foot wound infection. methods: eighteen patients with diabetic foot ulcer conforming to the study criteria were hospitalized in liyuan hospital affiliated to tongji medical college of huazhong university of science and technology from july 2014 to july 2015. diabetic foot ulcer wounds were classified according to the university of texas diabetic foot classification (hereinafter referre ... | 2017 | 28219141 |
| potassium iodide potentiates broad-spectrum antimicrobial photodynamic inactivation using photofrin. | it is known that noncationic porphyrins such as photofrin (pf) are effective in mediating antimicrobial photodynamic inactivation (apdi) of gram-positive bacteria or fungi. however, the apdi activity of pf against gram-negative bacteria is accepted to be extremely low. here we report that the nontoxic inorganic salt potassium iodide (ki) at a concentration of 100 mm when added to microbial cells (10(8)/ml) + pf (10 μm hematoporphyrin equivalent) + 415 nm light (10 j/cm(2)) can eradicate (>6 log ... | 2017 | 28207234 |
| antibacterial effect of sevoflurane and isoflurane. | multidrug resistant bacteria are increasing worldwide and therapeutic options are limited. some anaesthetics have shown antibacterial activity before. in this study, we have investigated the antibacterial effect of the halogenated anaesthetic agents sevoflurane and isoflurane against a range of resistant pathogens. | 2017 | 28198170 |
| patients hospitalized abroad as importers of multiresistant bacteria-a cross-sectional study. | the pandemic spread of multidrug-resistant (mdr) bacteria poses a threat to healthcare worldwide, with highest prevalence in indigent regions of the (sub)tropics. as hospitalization constitutes a major risk factor for colonization, infection control management in low-prevalence countries urgently needs background data on patients hospitalized abroad. | 2017 | 28196696 |
| in vitro screening of an fda-approved library against eskape pathogens. | bacterial resistance to conventional antibiotics is an increasingly serious threat to public health worldwide that requires immediate exploration and the development of novel antimicrobial compounds. drug repurposing is an inexpensive and untapped source of new antimicrobial leads, and it holds many attractive features warranting further attention for antimicrobial drug discovery. in an effort to repurpose drugs and explore new leads in the field of antimicrobial drug discovery, we performed a w ... | 2017 | 28190396 |
| aetiology and significance of hospital-acquired infections in mexico. | hospital-acquired infections (hais) are infections that develop in the hospital environment and can be acquired by a patient or hospital staff. they are complications that combine diverse risk factors that make an individual susceptible and are frequently caused by endogenous and exogenous bacterial agents. the most commonly studied etiological agents are bacteria and fungi, with the former representing the most common etiological agents reported to the hospital epidemiological surveillance netw ... | 2017 | 28182358 |
| in vitro activity of a polyhexanide-betaine solution against high-risk clones of multidrug-resistant nosocomial pathogens. | to determine the in vitro activity of a polyhexanide-betaine solution against collection strains and multidrug-resistant (mdr) nosocomial isolates, including high-risk clones. | 2017 | 27004429 |
| antimicrobial susceptibility among european gram-negative and gram-positive isolates collected as part of the tigecycline evaluation and surveillance trial (2004-2014). | european centers (n = 226) involved in the tigecycline evaluation and surveillance trial (test, 2004-2014) submitted data and bacterial isolates. | 2017 | 27216271 |
| structure-activity relationship-based screening of antibiotics against gram-negative acinetobacter baumannii. | to discover potent antibiotics against the gram-negative bacteria, we performed a structure-activity relationship (sar) study of yksa-6, which was the most potent inhibitor of staphylococcus aureus β-ketoacyl acyl carrier protein iii in our previous study. we identified and selected 11 candidates, and finally screened two active compounds, ykab-4 (4-[(3-chloro-4-methylphenyl)aminoiminomethyl]benzene-1,3-diol) and ykab-6 (4-[[3-(trifluoromethyl)phenyl]aminoiminomethyl]phenol) as inhibitors of aci ... | 2017 | 27840136 |
| classical β-lactamase inhibitors potentiate the activity of daptomycin against methicillin-resistant staphylococcus aureus and colistin against acinetobacter baumannii. | we asked whether beta-lactamase inhibitors (blis) increased the activity of daptomycin (dap) against methicillin-resistant staphylococcus aureus (mrsa), the peptide antibiotic colistin (col) against the emerging gram-negative nosocomial pathogen acinetobacter baumannii, and the human host defense peptide cathelicidin ll37 against either pathogen. dap and ll37 kill curves were performed with or without blis against mrsa, vancomycin-intermediate s. aureus (visa), and heterogeneous visa (hvisa). co ... | 2017 | 27872080 |
| association of biofilm production with colonization among clinical isolates of acinetobacter baumannii. | the pathogen acinetobacter baumannii is increasingly causing healthcare-associated infections worldwide, particularly in intensive care units. biofilm formation, a factor contributing to the virulence of a. baumannii, is associated with long-term persistence in hospital environments. the present study investigates the clinical impact of biofilm production on colonization and acquisition after patient admission. | 2017 | 27653617 |
| the ability of quaternary ammonium groups attached to a urethane bandage to inhibit bacterial attachment and biofilm formation in a mouse wound model. | for proper wound healing, control of bacteria or bacterial infections is of major importance. while caring for a wound, dressing material plays a key role as bacteria can live in the bandage and keep re-infecting the wound. they do this by forming biofilms in the bandage, which slough off planktonic bacteria and overwhelm the host defense. it is thus necessary to develop a wound dressing that will inhibit bacterial growth. this study examines the effectiveness of a polyurethane foam wound dressi ... | 2017 | 26712337 |
| broad-range detection of microorganisms directly from bronchoalveolar lavage specimens by pcr/electrospray ionization-mass spectrometry. | the clinical demand on rapid microbiological diagnostic is constantly increasing. pcr coupled to electrospray ionization-mass spectrometry, pcr/esi-ms, offers detection and identification of over 750 bacteria and candida species directly from clinical specimens within 6 hours. in this study, we investigated the clinical performance of the iridica bac lrt assay for detection of bacterial pathogens in 121 bronchoalveolar lavage (bal) samples that were received consecutively at our bacterial labora ... | 2017 | 28085931 |
| clumping factor a of staphylococcus aureus interacts with annexina2 on mammary epithelial cells. | staphylococcus aureus is one of major pathogens that can cause a series of diseases in different hosts. in the bovine, it mainly causes subclinical and contagious mastitis, but its mechanisms of infection are not fully understood. considering the fact that virulence factors play key roles in interactions between the bacterium and host cells, this study aimed to identify if a binding partner of s. aureus clumping factor a (clfa) exists on the bovine mammary epithelial cells. the clfa protein was ... | 2017 | 28102235 |
| antibacterial activities of the methanol extract, fractions and compounds from elaeophorbia drupifera (thonn.) stapf. (euphorbiaceae). | elaeophorbia drupifera (thonn.) stapf. (euphorbiaceae) is used in cameroonian folk medicine to treat several ailments including bacterial-related diseases such as skin infections. in this study, the methanol extract from the leaves (edl), fractions (edla-d), sub-fractions edlc1-7 and edlc31-35 as well as isolated compounds were tested for their antimicrobial activities against a panel of gram-negative and gram-positive bacteria including multidrug resistant (mdr) phenotypes. | 2017 | 28061888 |
| glycin-rich antimicrobial peptide yd1 from b. amyloliquefaciens, induced morphological alteration in and showed affinity for plasmid dna of e. coli. | antimicrobial peptides (amps), low-molecular-weight proteins with broad-spectrum antimicrobial activity, are the most promising candidates for the development of novel antimicrobials. a powerful cationic glycine-rich amp yd1 (mw ~ 1.0 kda) was purified from bacillus amyloliquefaciens cbsyd1 isolated from traditional korean fermented food kimchi, for the treatment of multidrug-resistant (mdr) bacteria. strain cbsyd1 was identified 99.79% similar to bacillus amyloliquefaciens subsp. plantarum fzb4 ... | 2017 | 28050849 |
| whole-genome sequencing of invasion-resistant cells identifies laminin α2 as a host factor for bacterial invasion. | to understand the role of glycosaminoglycans in bacterial cellular invasion, xylosyltransferase-deficient mutants of chinese hamster ovary (cho) cells were created using clustered regularly interspaced short palindromic repeat (crispr) and crispr-associated gene 9 (crispr-cas9) gene targeting. when these mutants were compared to the pgsa745 cell line, a cho xylosyltransferase mutant generated previously using chemical mutagenesis, an unexpected result was obtained. bacterial invasion of pgsa745 ... | 2017 | 28074024 |
| in vitro activity of linezolid in combination with photodynamic inactivation against staphylococcus aureus biofilms. | biofilm infections are a major challenge in medical practice. bacteria that live in a biofilm phenotype are more resistant to both antimicrobial therapy and host immune responses compared to their planktonic counterparts. so, there is need for new therapeutic strategies to combat these infections. a promising approach [known as photodynamic inactivation (pdi)] to kill bacteria growing as biofilms uses light in combination with a photosensitizer to induce a phototoxic reaction which produces reac ... | 2017 | 28090280 |
| isolation and identification of phyllospheric bacteria possessing antimicrobial activity from astragalus obtusifolius, prosopis juliflora, xanthium strumarium and hippocrepis unisiliqousa. | the widespread utilization of antimicrobial compounds has caused emergence of resistant microorganisms in the world. hence, the research to probe the products with antimicrobial features has led to finding natural habitats and discovering new pharmaceutical products. | 2017 | 28090278 |
| secondary metabolites from bacillus amyloliquefaciens isolated from soil can kill burkholderia pseudomallei. | bacillus species are gram-positive bacteria found in abundance in nature and their secondary metabolites were found to possess various potential activities, notably antimicrobial. in this study, bacillus amyloliquefaciens n2-4 and n3-8 were isolated from soil and their metabolites could kill burkholderia pseudomallei, a gram-negative pathogenic bacterium also found in soil in its endemic areas. moreover, the metabolites were able to kill drug resistant isolates of b. pseudomallei and also inhibi ... | 2017 | 28050857 |
| infective endocarditis risk after percutaneous pulmonary valve implantation with the melody and sapien valves. | this study compared the risk of infective endocarditis (ie) after percutaneous pulmonary valve implantation (ppvi) with the sapien and melody valves. | 2017 | 28279319 |
| antibacterial activity of tribulus terrestris and its synergistic effect with capsella bursa-pastoris and glycyrrhiza glabra against oral pathogens: an in-vitro study. | in this study, antimicrobial activities of an ethanol extract of tribulus terrestris aloneand in combination with capsella bursa-pastoris and glycyrrhiza glabra were examined in vitro against six pathogens namely streptococcus mutans, streptococcus sanguis, actinomyces viscosus, enterococcus faecalis staphylococcus aureus, and escherichia coli. | 2017 | 26101754 |
| secondary bacterial isolates from previously untreated buruli ulcer lesions and their antibiotic susceptibility patterns in southern nigeria. | mycolactones, secreted by mycobacterium ulcerans, were previously believed to prevent super infection in buruli ulcer lesions. however, little is known about secondary bacterial infections in these lesions. this study evaluated contaminating bacterial flora and their antibiotic susceptibility patterns in cases of previously untreated buruli ulcer disease from three states in southern nigeria. | 2017 | 28001222 |
| identification of ly2 members as antimicrobial peptides from zebrafish danio rerio. | the emergence of multidrug-resistant (mdr) microbes caused by overuse of antibiotics leads to urgent demands for novel antibiotics exploration. our recent data showed that ly2.1-3 (a novel lymphocyte antigen 6 (ly6) gene cluster) were proteins with cationic nature and rich in cysteine content, that are characteristic of antimicrobial peptides (amps) and their expression were all significantly up-regulated after challenge with lipopolysaccharide (lps). these strongly suggested that ly2.1-3 are po ... | 2017 | 27980020 |
| dietary myrtle (myrtus communis l.) improved non-specific immune parameters and bactericidal activity of skin mucus in rainbow trout (oncorhynchus mykiss) fingerlings. | the present study examined the effects of dietary myrtle (myrtus communis l.) on non-specific immune parameters and bactericidal activity of skin mucus in rainbow trout (oncorhynchus mykiss) fingerlings. three hundred and sixty fingerlings (6.50 ± 0.55 g (were distributed in twelve cages (65 × 65 × 65 cm) with a metal framework. the study included four treatments repeated in triplicates. the treatments were feeding trouts with experimental diets containing different levels (0, 0.5, 1 and 1.5%) o ... | 2017 | 28330807 |
| a galectin contributes to the innate immune recognition and elimination of pathogens in the freshwater mussel hyriopsis cumingii. | galectins are members of the lectin superfamily. they function as pattern recognition receptors in the innate immune system of vertebrates and invertebrates. a galectin homolog from the triangle sail mussel hyriopsis cumingii (hcgal2) was cloned and characterized. hcgal2 mrna was expressed in all tissues examined, displaying particular enrichment in mantle tissue. interestingly, rhcgal2 protein was only detected in the mantle, hemocytes, and gills, suggesting that post-transcriptional regulation ... | 2017 | 28300581 |
| bacterial coaggregation among the most commonly isolated bacteria from contact lens cases. | to examine the coaggregation and cohesion between the commonly isolated bacteria from contact lens cases. | 2017 | 28061510 |
| the effect of seasons on brazilian red propolis and its botanical source: chemical composition and antibacterial activity. | the aim of this study was to evaluate the effect of seasons on the chemical composition and antibacterial activity of brazilian red propolis (brp) and its plant source. brp was collected from maceio, alagoas state, north-east of brazil, during one year. chemical composition was determined by physicochemical analyses and hplc while antimicrobial activity was assessed against streptococcus mutans, streptococcus sobrinus, staphylococcus aureus and actinomyces naeslundii by determining the minimal i ... | 2017 | 27701899 |
| clinical and microbiological characteristics of bloodstream infections among patients with haematological malignancies with and without neutropenia at a medical centre in northern taiwan, 2008-2013. | this study aimed to investigate the epidemiology and microbiology of bloodstream infections (bsis) in patients with haematological malignancies. clinical characteristics and microbiology of 2083 patients with haematological malignancy who were treated for bsi from 2008 to 2013 at a medical centre in taiwan were retrospectively reviewed. lymphoma (38.1%) was the most common, followed by acute myeloid leukaemia (30.9%). of the 2090 non-duplicate bsi isolates, 1310 (62.7%) were recovered from patie ... | 2017 | 28109554 |
| evasion of neutrophil extracellular traps by respiratory pathogens. | the release of neutrophil extracellular traps (nets) is a major immune mechanism intended to capture pathogens. these histone- and protease-coated dna structures are released by neutrophils in response to a variety of stimuli, including respiratory pathogens, and have been identified in the airways of patients with respiratory infection, cystic fibrosis, acute lung injury, primary graft dysfunction, and chronic obstructive pulmonary disease. net production has been demonstrated in the lungs of m ... | 2017 | 27854516 |
| bactericidal and fungicidal activity of n-chlorotaurine is enhanced in cystic fibrosis sputum medium. | lung infections with multiresistant pathogens are a major problem of patients suffering from cystic fibrosis (cf). n-chlorotaurine (nct), a microbicidal active chlorine compound with no resistance development, is well tolerated upon inhalation. the aim of this study was to investigate nct on its bactericidal and fungicidal activity in vitro in artificial sputum medium (asm) mimicking the composition of cystic fibrosis mucus.the medium was inoculated with bacteria (staphylococcus aureus including ... | 2017 | 28223376 |