Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| the bile response repressor brer regulates expression of the vibrio cholerae breab efflux system operon. | enteric pathogens have developed several resistance mechanisms to survive the antimicrobial action of bile. we investigated the transcriptional profile of vibrio cholerae o1 el tor strain c6706 under virulence gene-inducing conditions in the presence and absence of bile. microarray analysis revealed that the expression of 119 genes was affected by bile. the mrna levels of genes encoding proteins involved in transport were increased in the presence of bile, whereas the mrna levels of genes encodi ... | 2008 | 18776020 |
| transition state analogues in quorum sensing and sam recycling. | transition state structures can be derived from kinetic isotope effects and computational chemistry. molecular electrostatic potential maps of transition states serve as blueprints to guide synthesis of transition state analogue inhibitors of target enzymes. 5'- methylthioadenosine phosphorylase (mtap) functions in the polyamine pathway by recycling methylthioadenosine (mta) and maintaining cellular s-adenosylmethionine (sam). its transition state structure was used to guide synthesis of mt-dadm ... | 2008 | 18776260 |
| a transient breach in the epithelial barrier leads to regulatory t-cell generation and resistance to experimental colitis. | previous studies have indicated that a defective epithelial barrier leads to inflammation of the underlying lamina propria. nevertheless, it is likely that physiologic breaks in the barrier must occur for homeostatic regulatory t cells to develop. we determined the effect of agents that disrupt epithelial tight junctions (ethanol and at1002, a vibrio cholerae zonula occludens toxin hexapeptide) on regulatory t-cell induction and resistance to induction of colitis by trinitrobenzene sulfonic acid ... | 2008 | 18765239 |
| intestinal adherence of vibrio cholerae involves a coordinated interaction between colonization factor gbpa and mucin. | the chitin-binding protein gbpa of vibrio cholerae has been recently described as a common adherence factor for chitin and intestinal surface. using an isogenic in-frame gbpa deletion mutant, we first show that v. cholerae o1 el tor interacts with mouse intestinal mucus quickly, using gbpa in a specific manner. the gbpa mutant strain showed a significant decrease in intestinal adherence, leading to less colonization and fluid accumulation in a mouse in vivo model. purified recombinant gbpa (rgbp ... | 2008 | 18765724 |
| preliminary x-ray diffraction analysis of yqjh from escherichia coli: a putative cytoplasmic ferri-siderophore reductase. | yqjh is a cytoplasmic fad-containing protein from escherichia coli; based on homology to viub of vibrio cholerae, it potentially acts as a ferri-siderophore reductase. this work describes its overexpression, purification, crystallization and structure solution at 3.0 a resolution. yqjh shares high sequence similarity with a number of known siderophore-interacting proteins and its structure was solved by molecular replacement using the siderophore-interacting protein from shewanella putrefaciens ... | 2008 | 18765906 |
| andrimid producers encode an acetyl-coa carboxyltransferase subunit resistant to the action of the antibiotic. | andrimid is a hybrid nonribosomal peptide-polyketide antibiotic that blocks the carboxyl-transfer reaction of bacterial acetyl-coa carboxylase (acc) and thereby inhibits fatty acid biosynthesis with submicromolar potency. the andrimid biosynthetic gene cluster from pantoea agglomerans encodes an admt gene with homology to the acetyl-coa carboxyltransferase (ct) beta-subunit gene accd. escherichia coli cells overexpressing admt showed resistance to andrimid. co-overproduction of admt with e. coli ... | 2008 | 18768797 |
| cholera toxin b accelerates disease progression in lupus-prone mice by promoting lipid raft aggregation. | infectious agents, including bacteria and viruses, are thought to provide triggers for the development or exacerbation of autoimmune diseases such as systemic lupus erythematosus in the genetically predisposed individual. molecular mimicry and engagement of tlrs have been assigned limited roles that link infection to autoimmunity, but additional mechanisms are suspected to be involved. in this study we show that t cells from lupus-prone mice display aggregated lipid rafts that harbor signaling, ... | 2008 | 18768857 |
| efficacy of partially hydrolyzed guar gum-added oral rehydration solution in the treatment of severe cholera in adults. | partially hydrolyzed guar gum (phgg) is a water-soluble fiber if added to oral rehydration solution (ors) and undergoes fermentation in the colon liberating short chain fatty acids (scfas). scfas potentiate the effect of ors, reducing the severity of diarrhea. | 2008 | 18769066 |
| motility and flagellin gene expression in the fish pathogen vibrio salmonicida: effects of salinity and temperature. | the success of several vibrio species, including vibrio cholerae, vibrio anguillarum and vibrio fischeri in colonizing their symbiont, or causing infection is linked to flagella-based motility. it is during early colonization or the initial phase of infection that motility appears to be critical. in this study we used vibrio salmonicida, a psychrophilic and moderate halophilic bacterium that causes cold-water vibriosis in seawater-farmed atlantic salmon (salmo salar), to study motility and expre ... | 2008 | 18634865 |
| riboswitches in eubacteria sense the second messenger cyclic di-gmp. | cyclic di-guanosine monophosphate (di-gmp) is a circular rna dinucleotide that functions as a second messenger in diverse species of bacteria to trigger wide-ranging physiological changes, including cell differentiation, conversion between motile and biofilm lifestyles, and virulence gene expression. however, the mechanisms by which cyclic di-gmp regulates gene expression have remained a mystery. we found that cyclic di-gmp in many bacterial species is sensed by a riboswitch class in messenger r ... | 2008 | 18635805 |
| molecular typing of vibrio cholerae o1 isolates from thailand by pulsed-field gel electrophoresis. | the aim of the present study was to genotypically characterize vibrio cholerae strains isolated from cholera patients in various provinces of thailand. two hundred and forty v. cholerae o1 strains, isolated from patients with cholera during two outbreaks, i.e. march 1999-april 2000 and december 2001-february 2002, in thailand, were genotypically characterized by noti digestion and pulsed-field gel electrophoresis (pfge). in total, 17 pfge banding patterns were found and grouped into four dice-co ... | 2008 | 18637531 |
| ballast water as a vector of coral pathogens in the gulf of mexico: the case of the cayo arcas coral reef. | the discharge of nutrients, phytoplankton and pathogenic bacteria through ballast water may threaten the cayo arcas reef system. to assess this threat, the quality of ballast water and presence of coral reef pathogenic bacteria in 30 oil tankers loaded at the pemex cayo arcas crude oil terminal were determined. the water transported in the ships originated from coastal, oceanic or riverine regions. statistical associations among quality parameters and bacteria were tested using redundancy analys ... | 2008 | 18639903 |
| putative virulence traits and pathogenicity of vibrio cholerae non-o1, non-o139 isolates from surface waters in kolkata, india. | vibrio cholerae non-o1, non-o139 was isolated from natural surface waters from different sites sampled in diarrhea endemic zones in kolkata, india. twenty-one of these isolates were randomly selected and included in the characterization. the multiserogroup isolates were compared by their virulence traits with a group of clinical non-o1, non-o139 isolates from the same geographic area. of the 21 environmental isolates, 6 and 14 strains belonged to heiberg groups i and ii, respectively. three of t ... | 2008 | 18641168 |
| atp negatively regulates the initiator protein of vibrio cholerae chromosome ii replication. | vibrio cholerae, the agent of cholera, has two circular chromosomes. in bacteria that contain a single chromosome, initiation of chromosome dna replication is mediated by dnaa, a aaa+ atpase that unwinds the origin of replication. there is little knowledge regarding initiation of chromosome replication in bacteria with more than one chromosome. here, we purified v. cholerae dnaa and rctb, which have been implicated in the replication of v. cholerae chromosome ii, and characterized their activiti ... | 2008 | 18647828 |
| [the diagnostic value of prescalene biopsy]. | 2008 | 2587553 | |
| american medical association white paper on elderly health. report of the council on scientific affairs. | 2008 | 2288622 | |
| [nephrotic syndrome]. | 2008 | 2293261 | |
| effective discharge preparation of elderly cataract day surgery patients. | nurses should ensure that prior to discharge, cataract surgery patients acquire basic knowledge about the surgical procedure, postsurgical recovery, and safe, appropriate health-care practices during early convalescence. the modified knowledge test may be a functional, easy to administer tool to assess and track patient's knowledge about their post-cataract surgery recovery and safe, appropriate health-care practices during the early convalescent period. patients can acquire most of the requisit ... | 2008 | 2374167 |
| the bush budget: cuts likely, with some medicaid expansion. | 2008 | 2648204 | |
| the bush budget: cuts likely, with some medicaid expansion. | 2008 | 2648204 | |
| malaria, the scourge of the tropics. historical references to malaria in sri lanka and some notable episodes up to present times. | 2008 | 3073872 | |
| malaria, the scourge of the tropics. historical references to malaria in sri lanka and some notable episodes up to present times. | 2008 | 3073872 | |
| bronchoscopic photodynamic therapy of bronchial carcinoma. | photodynamic therapy with photosensitizers is a new method of treating malignant tumors. in the area of bronchoscopy it is employed for the selective therapy of early carcinomas at central localizations. we report on our first attempts at treatment with hematoporphyrin derivative in an inoperable patient. the modalities of irradiation and the recurrence-free progress of, to date, 2.5 years, are described. | 2008 | 2612432 |
| bronchoscopic photodynamic therapy of bronchial carcinoma. | photodynamic therapy with photosensitizers is a new method of treating malignant tumors. in the area of bronchoscopy it is employed for the selective therapy of early carcinomas at central localizations. we report on our first attempts at treatment with hematoporphyrin derivative in an inoperable patient. the modalities of irradiation and the recurrence-free progress of, to date, 2.5 years, are described. | 2008 | 2612432 |
| [barium currents through single calcium channels of a nerve cell membrane]. | 2008 | 2580683 | |
| branch retinal vein occlusion. a clinicopathologic case report. | the eyes of a 72-year-old woman with a history of two branch retinal vein occlusions involving the left eye, were obtained postmortem and studied histopathologically. prior to her death, she had been enrolled in the multicentered, prospective, randomized clinical trial on branch vein occlusion and treated with peripheral argon laser photocoagulation for disc neovascularization. routine fluorescein angiograms and fundus photographs were available for clinical correlation. despite photocoagulation ... | 2008 | 2448855 |
| the pattern of cardiovascular malformation in the charge association. | congenital heart disease occurred in 64% of patients with the charge (coloboma, heart disease, choanal atresia, retardation of postnatal growth and mental development, genitalia hypoplasia, and ear anomalies) association (55% of 67 previously described patients and 100% of 16 new patients). of those with congenital heart disease, 42% had conotruncal anomalies (tetralogy of fallot, double-outlet right ventricle, truncus arteriosus), and 36% had aortic arch anomalies (vascular ring, aberrant subcl ... | 2008 | 2441595 |
| [alpha-amylase polymorphism. 1. a comparative study of alpha-amylase hp and gm]. | individual phenotypes, phenotypical and genetic frequencies of the alpha-amylase enzyme have been established by means of populational genetic researches. the most common phenotype is amyla amyl2a (85.15%) followed by amyla amyl2a 2b (6.27%), amylaib amyl2a (5.37%), amyl ia amyl2a 2b (2.15%), amyla amyl2b (0.53%), amylc amyl2b (0.35%), amylc amyl2a 2b (0.18%). the difference between the observed and theoretically expected phenotypes of amy, hp and m gm(1) is insignificant. the examined contingen ... | 2008 | 2627896 |
| mechanisms of action of slow-acting drugs in rheumatoid arthritis. | slow-acting anti-rheumatic drugs exhibit a number of similar properties in treated patients that suggest that they may have a common mode of action in rheumatoid arthritis. in vitro evaluation of drug action suggests that each of the slow-acting agents possesses immunosuppressive activity that may explain its therapeutic efficacy in rheumatoid arthritis. even though these agents appear to be able to suppress immune responses, the site of action of these agents differs. thus, gold compounds and t ... | 2008 | 2575024 |
| [a germ cell tumor of an ectopic testis in polyorchidism]. | 2008 | 2547104 | |
| panic attacks, buspirone, and serotonin function. | 2008 | 2570299 | |
| comparison of a vasodilating beta-blocker and a cardioselective beta-blocker in long-term treatment of hypertension: a european multicentre study. | the therapeutic effectiveness and safety of indenolol, a vasodilating beta-blocker with beta 2-agonism, was compared with that of atenolol, a cardioselective beta-blocker, in a 1-year double-blind trial. a total of 143 hypertensive patients (diastolic blood pressure 95-115 mmhg after 1 month of placebo) were randomly allocated to either atenolol, 50 mg/day, or indenolol, 60 mg/day. if the target diastolic blood pressure (less than or equal to 90 mmhg) was not reached after 1 month, the beta-bloc ... | 2008 | 2576667 |
| providing for the needs of handicapped candidates. | 2008 | 2533188 | |
| investigative protocols to treat malignant brain tumors in north america. | 2008 | 2648183 | |
| investigative protocols to treat malignant brain tumors in north america. | 2008 | 2648183 | |
| antenatal diagnosis of renal abnormalities: a review of the state of the art. | antenatal diagnosis of fetal abnormalities is an important component of genetic counseling. this paper reviews the indications and techniques of antenatal diagnosis of renal and urinary tract abnormalities, and outlines their follow-up and modes of treatment. | 2008 | 2644699 |
| [application of hemodilution to ischemic heart disease]. | 2008 | 2672312 | |
| risk adjustment in claims-based research: the search for efficient approaches. | claims-based indices of comorbidity and severity, as well as other measures derived from routinely collected administrative data, are developed and tested. the extent to which risk adjustments using claims can be improved by adding information from one well-known measure based on chart review and patient examination (the american society of anesthesiologists' (asa) physical status score) is also examined. readmissions and mortality after three common surgical procedures are the outcomes studied ... | 2008 | 2585010 |
| protein evolution on rugged landscapes. | we analyze a mathematical model of protein evolution in which the evolutionary process is viewed as hill-climbing on a random fitness landscape. in studying the structure of such landscapes, we note that a large number of local optima exist, and we calculate the time and number of mutational changes until a protein gets trapped at a local optimum. such a hill-climbing process may underlie the evolution of antibody molecules by somatic hypermutation. | 2008 | 2762321 |
| [fatal septum pellucidum cyst]. | case history of a patient with cysta septi pellucidi is described. pathomechanism of the symptoms and that of the fatal outcome is curtly analysed. it is stated that communicating cysta may become non-communicating one and vice versa, so in case of a known cysta when neurologic symptoms appear, causal role of it has to be considered. | 2008 | 2771394 |
| [fatal septum pellucidum cyst]. | case history of a patient with cysta septi pellucidi is described. pathomechanism of the symptoms and that of the fatal outcome is curtly analysed. it is stated that communicating cysta may become non-communicating one and vice versa, so in case of a known cysta when neurologic symptoms appear, causal role of it has to be considered. | 2008 | 2771394 |
| case report 543. osteofibrous dysplasia of tibia. | 2008 | 2749297 | |
| absence of dystrophin in becker muscular dystrophy. | 2008 | 2563029 | |
| in vitro and in vivo evaluation of granulocyte labeling with [99mtc]d,1-hm-pao. | the functional integrity of white blood cells labeled with [99mtc]d,1-hm-pao containing variable amounts of the ligand or of the 99mtc activity was evaluated by enzymatic tests and by measuring random migration, chemotaxis, phagocytosis, killing, and adhesion. the ultrastructure of labeled cells was studied by electron microscopy. the tracer dose and the hm-pao concentration did not significantly affect phagocytosis and killing. the results of the other tests remained normal. a maximum labeling ... | 2008 | 2585105 |
| model predicting survival in stage i melanoma based on tumor progression. | we used the lesional steps in tumor progression and multivariable logistic regression to develop a prognostic model for primary, clinical stage i cutaneous melanoma. this model is 89% accurate in predicting survival. using histologic criteria, we assigned melanomas to tumor progression steps by ascertaining their particular growth phase. these phases were the in situ and invasive radial growth phase and the vertical growth phase (the focal formation of a dermal tumor nodule or dermal tumor plaqu ... | 2008 | 2593166 |
| [immunoenzymatic determination of free immunoglobulin light chains in the cerebrospinal fluid: its value in the biological diagnosis of multiple sclerosis]. | based on previous data on free immunoglobulin light chains in the cerebrospinal fluid (csf) of patients with multiple sclerosis (ms), we evaluated free kappa and lambda light chains in the csf from 3 patients groups: (a) 42 with ms, (b) 16 with other neurological inflammatory diseases (onid) and (c) 42 with non inflammatory neurological diseases (nind) used as control. the kappa and lambda light chains contents were evaluated using a specific and sensitive (0.5 mcg/ml) enzyme linked immunosorben ... | 2008 | 2518740 |
| [pharmacologic therapy of bronchial asthma]. | the main feature in asthma is bronchial eosinophilic inflammation, induced, in genetically predisposed subjects, by known (aeroallergens, viral infection, occupational agents) and unknown agents. inflammation critically increases bronchial responsiveness so that even rather mild stimuli (exercise, cold air, mist, allergens) are able to induce obstructive reactions. when preventive measures (specific immunotherapy, avoidance of inflammatory and precipitating factors) are inadequate, a pharmacolog ... | 2008 | 2573115 |
| criteria that discriminate between native proteins and incorrectly folded models. | various theoretical concepts, such as free energy potentials, electrostatic interaction potentials, atomic packing, solvent-exposed surface, and surface charge distribution, were tested for their ability to discriminate between native proteins and misfolded protein models. misfolded models were constructed by introducing incorrect side chains onto polypeptide backbones: side chains of the alpha-helical hemerythrin were modeled on the beta-sheeted backbone of immunoglobulin vl domain, whereas tho ... | 2008 | 3186690 |
| [diabetes in the works of a piedmontese physician--g. f. arma da chivasso--of the 16th century]. | 2008 | 2519496 | |
| [chilean medicine during the government of president balmaceda]. | this is a conference dictated on the occasion of the centennial of the first chilean medical congress, the foundation of the first public health council and the school of medicine of the university of chile (1889). during the government of president balmaceda, prominent chilean physicians and university professors were closely linked to the presidency, often in public office or congress. the conditions were then created for an accelerated development of many aspects of chilean medicine, includin ... | 2008 | 2519385 |
| antenatal diagnosis of parenti-fraccaro type achondrogenesis. | 2008 | 2276781 | |
| a model for teaching periodontal surgery. | a simple laboratory-made model is described for periodontal surgical technique exercises. it has proved useful for tutor demonstration and student practice of all aspects of flap management. | 2008 | 2346697 |
| [organ injuries during gastrectomy in peptic ulcer]. | 2008 | 2259107 | |
| comment: i.v. alcohol in prevention of delirium tremens. | 2008 | 2275246 | |
| [a case of asymptomatic course of kidney tumor]. | 2008 | 2292876 | |
| asymmetric brain stem auditory evoked responses in infants treated with extracorporeal membrane oxygenation. | brain stem auditory evoked responses (baers) were obtained in 25 infants who received extracorporeal membrane oxygenation (ecmo) for severe respiratory failure. tracings were obtained by means of a nicolet ca-2000 averager, using a conventional paradigm. the presence or absence of replicated responses at 35 and 75 db nhl were recorded for each ear. interpeak latencies i-iii, iii-v, and i-v were measured and differences between right and left ears were compared, using a matched pair t-test. wave ... | 2008 | 2262085 |
| are more consultants needed for dermatology? | 2008 | 2258854 | |
| non-aids-associated kaposi's sarcoma (classical and endemic african types): treatment with low doses of recombinant interferon-alpha. | in the treatment of the classical and endemic african forms of kaposi's sarcoma (ks), radiation therapy and chemotherapy have been widely used with varying degrees of success and morbidity. we here report our preliminary experiences with low doses of recombinant interferon alfa-2b (rifn alpha-2b) in the treatment of these types of ks, non-linked to the acquired immunodeficiency syndrome (aids). ten consecutive patients (eight patients with classical and two with endemic ks) with a median age of ... | 2008 | 2258634 |
| study population in support: patients (as defined by disease categories and mortality projections), surrogates, and physicians. | 2008 | 2174967 | |
| the role of computerized microdiscs in dentistry. | 2008 | 3462054 | |
| [a case of posttraumatic cerebral air embolism]. | we report a case of cerebral air embolism that occurred after chest trauma. the diagnosis was confirmed by ct and skull roentgenogram which demonstrated air bubbles in intracranial arteries. it is well recognized that cerebral air embolism is caused by various diagnostic and therapeutic procedures, and trauma. but it may often be overlooked because it is diagnosed clinically and there are no characteristic symptoms nor signs. although various ways of treatment have been reported, prevention and ... | 2008 | 2586716 |
| centromeric dots in crane-fly spermatocytes: meiotic maturation and malorientation. | during the first meiotic division in crane-fly spermatocytes, the two homologs of a metaphase bivalent each bear two sister kinetochores oriented toward the same pole. we have previously reported treatments that increase the percentage of metaphase bivalents in which one or both homologs have bipolar malorientations: kinetochore microtubules extending from a homolog toward both poles. the maloriented homologs lag at anaphase. treatments that induce this behavior include: (a) recoverey from expos ... | 2008 | 2612294 |
| centromeric dots in crane-fly spermatocytes: meiotic maturation and malorientation. | during the first meiotic division in crane-fly spermatocytes, the two homologs of a metaphase bivalent each bear two sister kinetochores oriented toward the same pole. we have previously reported treatments that increase the percentage of metaphase bivalents in which one or both homologs have bipolar malorientations: kinetochore microtubules extending from a homolog toward both poles. the maloriented homologs lag at anaphase. treatments that induce this behavior include: (a) recoverey from expos ... | 2008 | 2612294 |
| effect of replacing glucose with lipid on the energy metabolism of newborn infants. | 1. indirect calorimetry and primed constant infusion of [u-13c]glucose were combined in 28 appropriate-for-gestational age newborn, parenterally fed infants, in order to measure glucose utilization and glucose oxidation and to estimate lipogenesis from glucose. 2. the infants were randomly allocated to either a group receiving glucose as the non-protein energy source or a group having one-quarter of the glucose energy replaced by intravenous fat. the energy intake (370 kj day-1 kg-1) and protein ... | 2008 | 2736877 |
| effect of replacing glucose with lipid on the energy metabolism of newborn infants. | 1. indirect calorimetry and primed constant infusion of [u-13c]glucose were combined in 28 appropriate-for-gestational age newborn, parenterally fed infants, in order to measure glucose utilization and glucose oxidation and to estimate lipogenesis from glucose. 2. the infants were randomly allocated to either a group receiving glucose as the non-protein energy source or a group having one-quarter of the glucose energy replaced by intravenous fat. the energy intake (370 kj day-1 kg-1) and protein ... | 2008 | 2736877 |
| primordial birdheaded nanism associated with progressive ataxia, early onset insulin resistant diabetes, goiter and primary gonadal insufficiency. a new syndrome. | a new syndrome in two siblings with primordial birdheaded nanism, progressive ataxia, goiter, primary gonadal insufficiency and insulin resistant diabetes mellitus is presented. plasma concentrations of tsh, pth, lh, fsh, acth, glucagon and insulin all working through cell membrane receptors were elevated. a generalized cell membrane defect was suggested to be the pathophysiological abnormality in these patients. | 2008 | 2662702 |
| characteristics of antibodies adsorbed on the dna immunoadsorbent, agarose poly-l-lysine-dna. | agarose-poly-l-lysine (ag-(lys)n-dna) has been used to bind dna for assay of anti-dna antibodies (ab). in this work, an algorithmic approach has been used to classify antinuclear ab (ana) as being directed against native dna (dsdna), denatured dna (ssdna), dna-protein complexes (deoxyribonucleoprotein; dnp), and against antigens which are independent of dna (idna). these ab were subjected to ag-(lys)n-dna, and the selectivity of this adsorbent for the various specificities of ab was determined. ... | 2008 | 2446798 |
| nasolacrimal abnormalities in oblique facial clefts. | a patient with a tessier no. 4 cleft and an associated bifid nasolacrimal system is presented and considered within the tessier classification of craniofacial clefting. previous accounts of nasolacrimal abnormalities associated with facial clefts are reviewed together with the accepted developmental embryology. it is proposed that the bifid nasolacrimal duct system described constitutes a new addition to the literature. | 2008 | 2393773 |
| regulation of metallothionein gene expression. | the metallothioneins are small, cysteine-rich proteins that have the capacity for high affinity binding of heavy metal ions, and whose synthesis is regulated by metal ion concentrations. these properties suggest that they play pivotal roles in the metabolism of the relatively nontoxic essential metals (zinc and copper), as well as toxic heavy metals (cadmium), a concept supported by a variety of studies of cells in culture, as well as in intact animals. expression of the metallothionein genes ma ... | 2008 | 2293243 |
| depression and organic mood disorder. | 2008 | 2211553 | |
| effects of the d-1 agonist skf-38393 combined with haloperidol in schizophrenic patients. | 2008 | 2405808 | |
| interspecies scaling and comparisons in drug development and toxicokinetics. | 1. methods of interspecies extrapolation using physiological models and allometric scaling have been reviewed with their possible application to drug development, both for candidate drug selection and the interpretation of toxicokinetic data. 2. physiological models offer a mechanistic approach to extrapolation from one species to another, examining individual components which interrelate to produce the characteristics of the whole system. tissues of interest are arranged in anatomical order bas ... | 2008 | 2275215 |
| enhanced net mass transfer of hdl cholesteryl esters to apo b-containing lipoproteins in patients with peripheral vascular disease. | in vitro net mass transfer of hdl cholesteryl ester to apolipoprotein (apo) b-containing lipoproteins (hdl-cet) was found to be nearly twofold higher in plasma from 35 male patients with peripheral vascular disease compared to the values of 27 age- and sex-matched healthy controls (p less than 0.001). differences in hdl-cet were predominantly observed between normolipidemic patients and controls, and were also demonstrable in pairs of patients and controls with similar hdl cholesterol, vldl + ld ... | 2008 | 2612001 |
| hepatic antipyrine metabolism in athletes. | the aim of the present study was to investigate the influence of prolonged physical exercise on hepatic metabolism. an oral antipyrine loading test (15 mg/kg body weight) was carried out on 24 healthy male subjects: 8 controls, 8 sprinters (anaerobic activity), 8 long distance runners (aerobic activity). antipyrine clearance resulted to be significantly higher in athletes vs. controls, without a significant difference between the two groups of athletes. these results put forward the importance o ... | 2008 | 2266756 |
| nasal mucosal temperature and the effect of acute infective rhinitis. | nasal mucosal temperature was measured in 71 healthy subjects with an electronic thermometer. no correlation was found between the nasal mucosal temperature and age or sex. an increased mucosal temperature was found in patients with acute rhinitis, an effect which is supposed to assist in the defence system against microorganisms. when measuring nasal mucosal temperature over a 7-h period at the same time as nasal airway resistance, there was no correlation between these factors, indicating that ... | 2008 | 2612033 |
| [meta-analysis. a systematic approach to the synthesis of knowledge]. | 2008 | 2620806 | |
| [meta-analysis. a systematic approach to the synthesis of knowledge]. | 2008 | 2620806 | |
| the buried running dermal subcutaneous suture technique. | this article illustrates the buried running dermal subcutaneous suture technique, a more rapid method for closing large fusiform open skin wounds than vertically oriented buried dermal subcutaneous sutures that are individually tied and cut. this technique effectively closes dead space, provides excellent strength, and relieves wound tension uniformly. | 2008 | 2646333 |
| leakage in vitro with irm, high copper amalgam, and eba cement as retrofilling materials. | an in vitro dye leakage study was performed to compare the sealing ability of high copper amalgam with copalite, irm, and eba cement when used as retrofilling materials. fifty-one extracted anterior teeth were instrumented and then obturated with gutta-percha. the apical 3 mm of the roots were resected and 2-mm deep apical preparations were made. the roots were then randomly placed into three groups and retrofilled with one of the experimental materials. after 72 h in india ink, the teeth were c ... | 2008 | 2607285 |
| sigmoid volvulus in kaduna, nigeria. | worldwide regional variations exist in the incidence of sigmoid volvulus. this article describes the experience with sigmoid volvulus at the ahmadu bello university teaching hospital in kaduna, nigeria. sixty of 121 patients who had large-bowel obstruction over a 15-year period had sigmoid volvulus. fifty-seven (95 percent) had gangrenous bowel. the mortality rate was 16.7 percent. the clinical presentation and the treatment modalities offered are discussed. | 2008 | 2376220 |
| binding modes of mammalian hepatic gal/galnac receptors. | mammalian gal/galnac receptors show dramatic preference for three-branched oligosaccharide structures over two- or one-branched counterparts. the spatial arrangement of the gal residues is extremely important for optimal binding. the three terminal gal residues in the best triantennary ligand are about 15-30 a apart, and therefore the sugar-combining sites on the receptor may also have the same geometry. the results obtained with synthetic ligands containing gal or galnac are in agreement with t ... | 2008 | 2551610 |
| [a case of an s-shaped kidney complicated by calculosis and hydronephrosis]. | 2008 | 2585989 | |
| characterization of high molecular weight glycosylated forms of murine tumor necrosis factor. | tumor necrosis factor (tnf) is synthesized as a prohormone with an unusually long and atypical signal sequence which is absent from the mature secreted cytokine. in addition to mature 17 kda tnf, lps-stimulated murine macrophages secrete at least seven tnf-like proteins (isoforms) of differing electrophoretic mobility which appear as a "ladder" on sds-page. we here present data indicating that these isoforms derive not from sequential clipping of propiece fragments, but rather from differential ... | 2008 | 2268312 |
| neuroendocrinology of the normal menstrual cycle. | the physiology of the ovarian/menstrual cycle is dependent on signaling whereby the "ovarian clock" modulates hypothalamic-pituitary function as well as endometrial proliferation and secretion and menses. diagnosis and treatment of infertility are based on these physiologic processes, as is contraceptive intervention. feedback stimulation and inhibition orchestrate fertility. | 2008 | 2654387 |
| bronchial and cardiovascular effects of ocular topical b-antagonists in asthmatic subjects: comparison of timolol, carteolol, and metipranolol. | b antagonists eye drops are most effective for the treatment of chronic open angle glaucoma. by this way of administration they have a very good systemic bioavailability. bronchial, and cardiovascular effects of three of these topicals: timolol, carteolol and metipranolol have been evaluated in three parallel groups of asthmatic patients. the three topics induce bronchoconstriction without significant difference between them, and lower heart rate (sometimes very intensely) whatever the b antagon ... | 2008 | 2565918 |
| colony-stimulating factor and drug-induced agranulocytosis. | 2008 | 2655524 | |
| colony-stimulating factor and drug-induced agranulocytosis. | 2008 | 2655524 | |
| neurolathyrism remains a threat in india. | 2008 | 2733776 | |
| neurolathyrism remains a threat in india. | 2008 | 2733776 | |
| developmental changes in children's awareness of strategies for coping with uncontrollable stress. | children at 3 age levels (5-6 1/2, 7 1/2-9, and 10-12 years) were interviewed to determine their spontaneous suggestions of coping strategies designed to manage frustration caused by waiting for a desired object (positive valence) and fear caused by waiting for an unpleasant event (negative valence) in uncontrollable situations. subjects' responses were grouped into categories based on coping techniques discussed in the adult coping literature on a continuum from approach to avoidance techniques ... | 2008 | 2612245 |
| developmental changes in children's awareness of strategies for coping with uncontrollable stress. | children at 3 age levels (5-6 1/2, 7 1/2-9, and 10-12 years) were interviewed to determine their spontaneous suggestions of coping strategies designed to manage frustration caused by waiting for a desired object (positive valence) and fear caused by waiting for an unpleasant event (negative valence) in uncontrollable situations. subjects' responses were grouped into categories based on coping techniques discussed in the adult coping literature on a continuum from approach to avoidance techniques ... | 2008 | 2612245 |
| identity of pb76 differentiation antigen and lymphocyte alkaline phosphatase. | alkaline phosphatases (apases, ec 3.1.3.1) are ecto-enzymes bound to cell membranes by a phosphatidyl-inositol anchor. we have previously shown that apase is present on activated murine b cells and its expression correlates with the process of b cell differentiation into immunoglobulin secretion. recently, a monoclonal antibody (mab), g-5-2, that recognizes a 76-kda molecule preferentially expressed on the surface of pre-b and plasma cells (pb76) was described. some features shared by apase and ... | 2008 | 2347370 |
| [extrathoracic versus transthoracic methods of surgical correction of stenoses and occlusions of the aortic arch branches: a comparison]. | 125 reconstructions performed during the years 1968 to 1988 were analysed retrospectively. 81 surgical procedures were extrathoracic (64.8%) and 44 transthoracic (35.2%). the symptoms of the aortic arch branch lesions included subclavian steal syndrome in 67 (53.6%), transient cerebral ischemia in 16 (12.8%), residua of cerebral infarction in 5 (4.0%), monocular ischemic attacks in 16 (12.8%) and ischemic arm symptoms in 27 (21.6%) patients. surgical repair was achieved by subclavian-carotid tra ... | 2008 | 2588596 |
| [ischemic colitis and recurrent venous thrombosis caused by familial protein s deficiency]. | 2008 | 2533119 | |
| [method of isolating fmrf-amide-like substances in the snail, using affinity chromatography coupled with hplc]. | an extraction procedure of fmrfa-like substances from brain of helix aspersa was developed. it consists of using affinity chromatography coupled with reverse phase hplc. three synthetic peptides (fmrfa, pqdpflrfa, met-enkephalin) were used to evaluate the specificity and yield of the affinity column. its efficiency was tested by use of snail brain extracts. the results showed that this method is efficient and reproducible. | 2008 | 2575010 |
| a mechanism for cross-lineage gene rearrangements in b-cell neoplasm. | the organization of immunoglobulin heavy chain (igh) gene of b precursor cell acute lymphoblastic leukemia (all) was examined in order to elucidate the mechanism causing simultaneous tcr gene rearrangements. study using a 5'd probe lying 20 kb upstream of igh d region genes was useful to distinguish diversity(d)-joining(j) recombination(dj) from variable(v)-dj recombination(vdj). indeed, igh gene structures determined by 5'd study well correlated to those recognized by dj or vdj transcripts. igh ... | 2008 | 2519516 |
| doxepin-induced cardiac dysrhythmia. | 2008 | 2453531 | |
| diffuse axonal injury: analysis of 100 patients with radiological signs. | one hundred patients with head injuries who showed diffuse axonal injury on computed tomographic scans are reported. evaluation of the glasgow coma score, pupillary signs, and computed tomographic findings on admission led to an improved ability to forecast outcomes. our relatively good results as compared with other series, can be explained by the high proportion of children and by the liberal use of computed tomography to evaluate head injuries, thus revealing that concussion may sometimes be ... | 2008 | 2234337 |
| [the gynecology clinic in the era of electronic data processing]. | 2008 | 2583592 | |
| regression of left ventricular hypertrophy in hypertension with alpha-adrenergic blockade: physiological basis and therapeutic implications. | left ventricular hypertrophy may be a serious consequence of chronic untreated hypertension since it may accentuate the risk of congestive heart failure, arrhythmias, coronary ischaemias and sudden death. although haemodynamic factors may play a role in the genesis of left ventricular hypertrophy, certain neurohumoral mechanisms such as the adrenergic nervous system may induce left ventricular hypertrophy in patients with hypertension. there is considerable evidence to implicate adrenergic activ ... | 2008 | 2576672 |