Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| aflatoxins and fungal flora in lentil (lens esculenta l.). | fungal flora of 20 samples of lentil seeds collected from assiut governorate, egypt, were studied. seventeen genera and 13 species were isolated on glucose- (15 genera and 27 species), cellulose- (15 genera and 25 species)- czapek's agar media at 28 degrees c. the most common species were as follows: on glucose-czapek's agar, aspergillus fumigatus, a. niger, a. flavus, a. terreus, penicillium notatum and rhizopus oryzae and on cellulose agar, a. fumigatus, a. niger, a. flavus and p. notatum. thi ... | 1988 | 3419482 |
| serum antibodies to aspergillus fumigatus catalase in patients with cystic fibrosis. | seven to ten percent of patients with cystic fibrosis had serum antibodies to the catalase antigen of aspergillus fumigatus in three cross-sectional surveys between 1977 and 1984. a total of 208 patients participated at least once, and the cumulated frequency of catalase antibodies in 94 patients included in all three surveys was 16%. the titre range was 1 to 16. the prevalence rate of aspergillus fumigatus in sputum was 50% for a 2.5-year observation period. catalase antibodies were strongly as ... | 1988 | 3132374 |
| adrenal mass in an immunocompromised man. | 1988 | 3132469 | |
| aspergillus in pulmonary infections. | 1988 | 3133316 | |
| mic and fungicidal activity of terbinafine against clinical isolates of aspergillus spp. | terbinafine and amphotericin b mics for 90% of strains tested were 1.6 and 0.4 micrograms/ml against aspergillus fumigatus (16 strains), 0.8 and 3.2 micrograms/ml against aspergillus flavus (10 strains), and 0.4 and 1.6 micrograms/ml against aspergillus niger (10 strains), respectively. for all species tested, the minimal inhibitory and fungicidal concentrations for 90% of strains of both drugs were identical and the inoculum size did not have a major effect on the results. | 1988 | 3134851 |
| leukotriene c4 generation from human eosinophils stimulated with igg-aspergillus fumigatus antigen immune complexes. | sepharose beads coated with igg stimulate eosinophils to produce leukotriene c4 (ltc4). this observation has been extended with specific immobilized igg/antigen immune complexes to elicit mediator generation. an extract of aspergillus fumigatus was covalently coupled to sepharose beads and incubated with the igg fraction of immune serum from patients with allergic bronchopulmonary aspergillosis. these beads elicited generation of 7.72 +/- 1.7 pmol of ltc4 immunoreactive material (n = 5) from 1 x ... | 1988 | 3139729 |
| dot-immunobinding assay in the detection of igg antibodies against farmer's lung antigens. | circulating antibodies against faenia rectivirgula, thermoactinomyces candidus, t. vulgaris and aspergillus fumigatus were studied in the sera of 14 clinically proven farmer's lung patients and 10 normal controls using three immunological methods. these methods were agar gel double diffusion (dd), biotin-avidin-linked immunosorbent assay (balisa) and dot-immunobinding assay (diba). agar gel diffusion, the least sensitive of the three methods, failed to detect antibodies in some of the patients, ... | 1988 | 3140016 |
| an investigation of the bactericidal and fungicidal effects of certain disinfectants by use of a capacity test. | the bactericidal and fungicidal effects of five disinfectants and one combination of two disinfectants were tested using a modified kelsey-sykes method in which living microorganisms suspended in a sterilized yeast suspension ("dirty" conditions) and in sterile distilled water ("clean" conditions) were added to the disinfectants in three stages. six bacteria and two fungal organisms were employed as test microbes. results showed that formaldehyde was virtually inactive at the dilution tested (1/ ... | 1988 | 3140847 |
| catabolism of single ring aromatic acids by four aspergillus species. | four species of the genus aspergillus, viz a. fumigatus, a. japonicus, a. niger and a. terreus, decarboxylated, demethoxylated and ring-cleaved aromatic compounds but to different extents. decarboxylation of vanillate occurred before ring-cleavage, which preceded the release of 14co2 from the methoxyl group. a large proportion of labelled carbon from the ring of ferulate and vanillate was found in particulate or trichloracetic acid precipitable material of homogenized fungal mycelium. the four a ... | 1988 | 3144642 |
| sterilization potential of contact lens solutions. | 1988 | 3148554 | |
| isolation of aflatoxin from acacia and the incidence of aspergillus flavus in the sudan. | a total of 1300 seeds from 13 commodities were surveyed for aspergillus flavus. an additional inoculum was obtained from 6 divergent sources. a. flavus isolants, randomly selected on the bases of visual cultural characteristics and inoculum source, were assayed for aflatoxin yielding capacity. out of 97 analyzed isolates 76 (78.3%) were aflatoxin-elaborators of which 27 (27.8%) colonies were classified as very highly toxinogenic (greater than 1000 micrograms/kg). acacia, described a new source o ... | 1988 | 3148862 |
| serological diagnosis of aspergillus infections. | 1988 | 3152082 | |
| aspergillus fumigatus fungus ball in hospitalized patients with chronic pulmonary disease. usefulness of double immunodiffusion test as a screening procedure. | double immunodiffusion (did) was used as a screening test for the diagnosis of aspergillosis. three hundred and fifty patients were tested, all of them referred from a specialized chest disease hospital and without a definitive etiological diagnosis. when did was positive additional information such as clinical history and radiographic findings were requested and also surgical specimens were obtained whenever possible. specific precipitin bands for aspergillus fumigatus antigen were found in 29 ... | 1988 | 3152275 |
| detection of antibodies against aspergillus fumigatus: comparison between double immunodiffusion, elisa and immunoblot analysis. | the performance of elisa to detect igg and igm antibodies to aspergillus fumigatus has been evaluated in strongly precipitin-positive, weakly precipitin-positive and precipitin-negative patient sera, with immunoblot analysis as the confirmatory test. all strongly precipitin-positive sera contained increased igg titers and showed clearly positive immunoblot patterns. most of the weakly precipitin-positive sera contained elisa titers within the normal range established with sera of healthy blood d ... | 1988 | 3123399 |
| studies on antifungal agents. 23. novel substituted 3,5-diphenyl-3-(1h-imidazol-1-ylmethyl)- 2-alkylisoxazolidine derivatives. | the synthesis and antifungal activity of a novel series of substituted 3,5-diphenyl-3-(1h-imidazol-1-ylmethyl)-2-alkylisoxazolidine derivatives (15-30) are described. the synthesis of the title compounds was accomplished via a 1,3-dipolar cycloaddition reaction of alpha-substituted ketonitrones with appropriate styrene precursors. the compounds when tested in vitro in solid agar cultures exerted a very potent antifungal activity against a wide variety of yeast and systemic mycoses and dermatophy ... | 1988 | 3172137 |
| [infectious pneumopathies in immunodepressed patients. value of the study of bronchoalveolar lavage fluid]. | during a period of 16 months 26 fluid specimens obtained by broncho-alveolar lavage (bal) in 24 immunocompromised patients were examined. this material included 13 hiv positive patients and 11 patients presenting malignant hemopathies (mh), of whom 7 had had a blood marrow transplantation. the bal fluid was divided into two equal parts, one of which was sent to the institute of pathology and the other to the laboratory of bacteriology of geneva university hospital. in some cases a transbronchial ... | 1988 | 3175570 |
| unusual clustering of allergic bronchopulmonary aspergillosis in children with cystic fibrosis. | allergic bronchopulmonary aspergillosis has been recognized in association with cystic fibrosis in children since 1965. since then, however, there have been a paucity of reports of pediatric cystic fibrosis complicated by allergic bronchopulmonary aspergillosis, and, in most cases, these have been diagnosed retrospectively. a cluster of five acute cases seen during a 4-month period in a single cystic fibrosis center with a systemic illness and deterioration in respiratory status are described. i ... | 1988 | 3186372 |
| 5-( [aryl or aryloxy (or thio)]methyl)-3-(1h-imidazol-1-ylmethyl)-3- (2-thienyl)-2-methylisoxazolidine derivatives as novel antifungal agents. | the in vitro antifungal activity of a novel series of cis- and trans-5-([aryl or aryloxy (or thio)]methyl)-3-(1h-imidazol-1-ylmethyl)-3- (2-thienyl)-2-methylisoxazolidines (13-24) was evaluated and compared with ketoconazole. the title series of compounds was prepared via a 1,3-dipolar cycloaddition reaction of 1-(2-thienyl)-2-(1h-imidazol-1-yl)-n-methylethanimine n-oxides with appropriate styrenes, allyl phenyl ethers, or allyl phenyl thioether precursors. the resulting products were mixtures o ... | 1988 | 3244110 |
| immunoconjugate generation between the ribosome inactivating protein restrictocin and an anti-human breast carcinoma mab. | in the perspective of therapeutic approaches the monoclonal antibody, mbrl, with a quite restricted spectrum of reactivity for human breast carcinoma, was coupled to restrictocin (res), a ribosome inactivating protein produced by aspergillus restrictus. in a cell-free system this toxin was found to have an activity comparable to that of other plant toxins, but its in vitro toxicity was shown to be low on different cell lines. three batches of mbr1-res conjugate were prepared and their specificit ... | 1988 | 3258791 |
| allergic bronchopulmonary aspergillosis. | allergic bronchopulmonary aspergillosis is primarily an immunologic disorder manifested by episodic bronchial obstruction (asthma or chronic obstructive pulmonary disease). the host response to local aspergillus antigens gradually results in irreversible pulmonary injury. a high index of suspicion is required to make the diagnosis. early and aggressive treatment is important in preventing the serious consequences of central bronchiectasis, pulmonary fibrosis and cor pulmonale. | 1988 | 3276099 |
| aspergillus fumigatus infection of the maxillary sinus. a case report. | the diagnosis and radiological findings in a 48-year-old woman with paranasal sinus aspergillus fumigatus infection is described. the patient had had chronic post-nasal discharge and sinusitis for 7 years. she was treated by total removal of all infected material. | 1988 | 3277293 |
| partial characterization of a rapidly released antigenic/allergenic component (ag 5) of aspergillus fumigatus. | an antigenic component of aspergillus fumigatus, which was responsible for inducing an initial early antibody response in rabbits immunized with a. fumigatus germlings, has been identified and partially characterized. by immunofluorescent antibody and elisa techniques, this antigen was demonstrated to be present on the germling surface, although it was also detected in supernatants of conidia/germlings within 1 hour and was present in all shake and stationary culture-filtrate extracts. by incorp ... | 1988 | 3279096 |
| [primary empyema caused by aspergillus]. | 1988 | 3279277 | |
| necrotizing otitis externa due to aspergillus in an immunocompetent patient. | an 85-year-old, nondiabetic man is described with necrotizing (malignant) otitis externa. the patient developed facial nerve paralysis in the presence of a progressive cellulitis and chondritis of the external auditory meatus. destruction of the bony meatus and mastoid and obliteration of normal soft-tissue planes at the skull base were documented by computed tomographic scans. aspergillus fumigatus was isolated from the external meatus and deep tissue specimens. fungal invasion of bone and soft ... | 1988 | 3281697 |
| clinical and serological survey of pulmonary aspergillosis in patients with cystic fibrosis. | a 5.5-year survey revealed 9 patients with allergic bronchopulmonary aspergillosis (abpa) and 1 patient with a highly probable diagnosis among 200 danish patients with cystic fibrosis (cf). the incidence of abpa was 0.9 (0.4-1.7, 95% confidence limits) per 100 patients per year. all the patients with definite or probable abpa had serum antibodies to the aspergillus fumigatus catalase antigen, and in 5 patients the appearance of catalase antibodies during the incipient phase of abpa was documente ... | 1988 | 3281913 |
| aspergillosis of the nose and paranasal sinuses in immunocompromised children. | 1988 | 3284628 | |
| assessment of immunoblotting in the investigation of specific immune responses during infection. | 1988 | 3286316 | |
| [allergic bronchopulmonary aspergillosis with hay dust-induced alveolitis and bronchial asthma]. | a 55-year-old female farmer had all the clinical, biochemical and radiological signs diagnostic of allergic bronchopulmonary aspergillosis. remarkably she also had symptoms of farmer's lung and exogenous allergic bronchial asthma with specific types i and iii sensitisation due to aspergillus antigens inhaled with straw-dust. in addition to the usual asthma treatment she also received antimycotic agents and corticosteroids. antigen exposure was strictly avoided. these measures brought about lasti ... | 1988 | 3292187 |
| isolation and characterization of a relevant aspergillus fumigatus antigen with igg- and ige-binding activity. | an immunologically relevant antigen fraction was isolated from a cytoplasmic extract of aspergillus fumigatus mycelium. the fraction was obtained by concanavalin-a affinity chromatography and hydrophobic interaction chromatography. two protein bands were discernible in polyacrylamide gel electrophoresis while two precipitin peaks were detected in crossed immunoelectrophoresis. when tested against sera from patients with aspergillus-induced diseases, the fraction showed both igg and ige antibody- ... | 1988 | 3292438 |
| factors affecting protoplast release from some mesophilic, thermophilic and thermotolerant species of filamentous fungi using novozym 234. | factors affecting the release of protoplasts from mycelia of aspergillus fumigatus, aspergillus niger, penicillium ochrochloron and geosmithia emersonii were investigated. protoplast yields were found to be greatly dependent on the growth temperature, incubation conditions, lytic enzyme system, mycelial age and mycelial concentration. high yields of protoplasts were obtained from all four organisms after a 3 h incubation with 1 mg/ml novozym 234 in 0.1 m 2-n-[morpholino] ethane sulphonic acid (m ... | 1988 | 3292876 |
| in vitro activity of enilconazole against aspergillus spp. and its fungicidal efficacy in a smoke generator against aspergillus fumigatus. | 1988 | 3292911 | |
| [pulmonary and cerebral aspergillosis in burkitt's lymphoma]. | multiple intracerebral aspergillus abscesses in a 5 year old boy with a burkitt's lymphoma are described. the disease was fatal despite antifungal treatment. the diagnostic and therapeutic problems, the risk factors and preventive care are discussed. | 1988 | 3293010 |
| [invasive pulmonary aspergillosis]. | invasive pulmonary aspergillosis is an opportunistic pneumonia which is particularly common in immuno-depressed subjects. the most frequent risk factors are the intensity and duration of leucopaenia, cytotoxic drugs and steroid therapy. in the respiratory tract, the proliferation of aspergillus fumigatus becomes possible when there is a failure of the reticulo-endothelial system and of the polymorphonuclear leucocytes. there is no typical clinical picture: one sees an acute febrile pneumonia res ... | 1988 | 3293130 |
| [histological study of a case of chondrocostal aspergillosis]. | histological study of biopsy specimens successively taken from the 7th, 5th and 6th right chondrocostal regions in a 33 year-old man; the patient was under chemotherapy for a diffuse lymphoma and has been operated for an aspergilloma of the right lung superior lobe. non-specific chronic osteomyelitis was observed as well as aspergillus fumigatus perichondritis (acute and chronic) which had lead to cartilage fragmentation. cartilage fragmentation could be attributed to an enzymatic chondrolysis i ... | 1988 | 3293580 |
| aspergillus endocarditis in association with a false aortic aneurysm. | a 32-year-old man was admitted with an intracerebral hematoma and subsequently with bilateral femoral emboli five months after aortic valve replacement. blood cultures for bacteria and fungi were negative but microscopy of the embolus revealed aspergillus fumigatus. at operation a large false aneurysm of the ascending aorta and vegetations on the prosthetic aortic valve were found. aspergillus endocarditis is diagnosed antemortem in only 23% of fatal aortic aneurysms: blood cultures are positive ... | 1988 | 3293861 |
| fatal aspergillosis associated with smoking contaminated marijuana, in a marrow transplant recipient. | a 34-year-old man presented with pulmonary aspergillosis on the 75th day after marrow transplant for chronic myelogenous leukemia. the patient had smoked marijuana heavily for several weeks prior to admission. cultures of the marijuana revealed aspergillus fumigatus with morphology and growth characteristics identical to the organism grown from open lung biopsy specimen. despite aggressive antifungal therapy, the patient died with disseminated disease. physicians should be aware of this potentia ... | 1988 | 3293934 |
| analysis of bronchoalveolar lavage in allergic bronchopulmonary aspergillosis: divergent responses of antigen-specific antibodies and total ige. | bronchoalveolar lavage (bal) was performed in eight patients with allergic bronchopulmonary aspergillosis (abpa) at a time when chest roentgeongraphy did not reveal an infiltrate, and respiratory status was stable. bal was tolerated well by all patients with only one patient experiencing mild wheezing. bal fluid recovery averaged 40%, and total cells/lavage were 22.3 x 10(6) (range 3.5 to 49.5 x 10(6)). cell viability, as determined by trypan blue exclusion, averaged 48% (range 34% to 60%). mean ... | 1988 | 3042837 |
| lectin-like attachment sites on murine pulmonary alveolar macrophages bind aspergillus fumigatus conidia. | murine pulmonary alveolar macrophages bound aspergillus fumigatus conidia in vitro at 4 c and 37 c in the absence of serum or opsonins. this attachment was dependent on calcium and was sensitive to mild trypsinization and paraformaldehyde pretreatment of the macrophage membrane. chitotriose, n-acetylglucosamine, d-mannose, alpha-methyl-mannoside, and l-fucose, but not d-galactose, were effective inhibitors of conidial binding. this pattern of reduction of conidial binding was consistent with tha ... | 1988 | 3042877 |
| effect of immunosuppression and amphotericin b on aspergillus antigenemia in an experimental model. | a modified enzyme-linked immunosorbent assay (elisa) for crude carbohydrate antigen was used to evaluate the kinetics of aspergillus antigenemia and to determine the effect of therapy on circulating antigen levels in an experimental model. the elisa was rapid, simple to perform, and able to detect less than 10 ng of antigen/ml of serum. the model was also used to evaluate the effect of temporary and persistent immunosuppression on experimental disease. antigen levels rose progressively in untrea ... | 1988 | 3042878 |
| production and characterization of a murine monoclonal antibody to aspergillus fumigatus antigen having igg- and ige-binding activity. | by employing hybridoma technology, a monoclonal antibody against aspergillus fumigatus was produced. this antibody, isotyped as igm k, reacted with 12 of 16 antigens extracted from 9 different a. fumigatus strains. this antibody also reacted with all 3 aspergillus flavus antigens studied, but not with aspergillus niger, aspergillus terreus, penicillium notatum or candida albicans antigens. western blot analysis indicated that this antibody reacted with two concanavalin a (con-a) binding bands of ... | 1988 | 3045013 |
| [mycologic analyses of house dust in patients with mycotic infections of the paranasal sinuses and in healthy probands]. | dust samples from 30 patients suffering from an aspergillus sinusitis and from 20 healthy persons were analysed for moulds as a possible cause of mycotic sinusitis. questionnaires were also distributed to assess the ecological environment of the patients. mycological analyses of the dust samples showed no statistical difference in the presence of moulds, especially those of aspergillus fumigatus and aspergillus niger. both moulds were found to roughly the same extent in 75%-95% of subjects. the ... | 1988 | 3045056 |
| [pseudo-allergic rhinitis in sinus aspergillosis. apropos of a case]. | 1988 | 3045939 | |
| igg antibodies to aspergillus fumigatus in cystic fibrosis: a laboratory correlate of disease activity. | serum was collected from 50 patients with cystic fibrosis, and igg antibodies to aspergillus fumigatus were measured by enzyme linked immunosorbent assay (elisa). in addition, total ige and aspergillus specific ige antibodies were measured in 41 of the 50. a close association was found between pulmonary function and clinical state, and igg antibodies to aspergillus. there was no association between pulmonary function or clinical state and ige antibodies. it is postulated that in patients with cy ... | 1988 | 3046514 |
| infection of the central nervous system in organ transplant recipients. | infections of the central nervous system are an important cause of morbidity and mortality in recipients of organ transplants. three organisms--listeria monocytogenes, aspergillus fumigatus, and cryptococcus neoformans--account for the great majority of such infections. the incidence of these infections is directly related to the patient's net state of immunosuppression and to the epidemiologic exposures he encounters. there is an expected timetable of when particular infections are likely to oc ... | 1988 | 3047541 |
| electroretinograms in early fungal endophthalmitis. | to facilitate the early diagnosis of exogenous fungal endophthalmitis, we developed a rabbit model for aspergillus fumigatus endophthalmitis. six eyes of six new zealand white rabbits were inoculated with forty spores of a. fumigatus. a control group of their six contralateral eyes received a similar but sterile inoculum. the rabbit eyes were evaluated with respect to clinical appearance and the electroretinogram. clinically evident endophthalmitis developed in all six infected eyes at an averag ... | 1988 | 3048943 |
| experimental aspergillosis in japanese quails (coturnix coturnix japonica). clinical signs and haematological changes. | intratracheal inoculation of 2-week-old quail chicks with aspergillus fumigatus resulted in the development of clinical signs within 24 h of infection. these were characterized by anorexia, depression, accelerated respiration and gasping followed by death. the acute course of the disease lasted for 7-10 days followed by recovery in the surviving chicks. the overall mortality during a 6-week observation period was 20%. although the mean body weight of a. fumigatus infected quail chicks continued ... | 1988 | 3050527 |
| studies on antifungal agents. 17. effects of the c-5-substitution on the in vitro activity of novel 3,5-substituted isoxazolidines. | a number of novel 5-(substituted thiomethyl)-3-phenyl-3-(1h-imidazol-1-ylmethyl)-2- methylisoxazolidine derivatives were prepared and evaluated in vitro for antifungal activity in solid agar cultures against trichophyton rubrum, aspergillus fumigatus and candida albicans. the effect of the 5-(substituted thiomethyl) group on the degree and scope of activity was studied and compared to that of the corresponding 5-phenoxymethyl and 5-[(substituted phenyl)thio(or amino)methyl] derivatives. | 1988 | 3053064 |
| [disseminated aspergillosis with marked morphological and functional defects of polymorphonuclear leukocytes in a case of myelodysplastic syndrome]. | 1988 | 3054200 | |
| effects of t-2 mycotoxin ingestion on phagocytosis of aspergillus fumigatus conidia by rabbit alveolar macrophages and on hematologic, serum biochemical, and pathologic changes in rabbits. | rabbits were given t-2 mycotoxin orally at 0, 0.25, 0.5, and 0.75 mg/kg of body weight/day for 21 days. only rabbits in the 0.75 mg/kg/day group (4 of 5 rabbits) died. alveolar macrophages were harvested on day 22 and used for in vitro phagocytosis of killed aspergillus fumigatus conidia. cultures included sera from untreated rabbits or rabbits treated with t-2. phagocytosis was significantly (p less than 0.01) reduced in cultures that used serum from rabbits treated with 0.5 mg of t-2/kg/day an ... | 1988 | 3056139 |
| [obstructive bronchial aspergillosis of favorable course under corticoids in a hiv seropositive patient]. | 1988 | 3056177 | |
| sequential pathological studies in japanese quails infected experimentally with aspergillus fumigatus. | intratracheal inoculation of young quail chicks with aspergillus fumigatus spores resulted in the development of characteristic gross and microscopic lesions. the lesions were restricted to respiratory tract and there was no dissemination of infection to other tissues of the body. gross changes in lungs and air sacs were observed within 24 hours and continued up to 20 days while in trachea these were noticed from the 3rd to the 9th day post-infection. the lesions, in general, included congestion ... | 1988 | 3057379 |
| a case of aspergillus osteomyelitis complicating an open fracture of the tibia. | 1988 | 3058608 | |
| serum antibodies to the catalase antigen of aspergillus fumigatus in cattle. | 1988 | 3059782 | |
| interferon protects mice against an extracellular infection of aspergillus fumigatus. | 1988 | 3063178 | |
| [a rare case of aspergilloma of the maxillary sinus]. | 1988 | 3063937 | |
| allergic bronchopulmonary aspergillosis: report of three cases. | 1988 | 3067130 | |
| brainstem invasion by aspergillus fumigatus in a child with leukemia. | 1988 | 3068594 | |
| surgery for pulmonary aspergilloma and pleural aspergillosis. | pulmonary aspergilloma and pleural aspergillosis are a potentially lifethreatening disease resulting from the colonization of lung or pleural cavities by the ubiquitous fungus aspergillus fumigatus. twenty four patients with pulmonary aspergilloma and five with pleural aspergillosis underwent major thoracic procedures at our hospital between 1976 and 1986. fourteen of the patients had haemoptysis, in 9 it was recurrent, and in 5 life-threatening. tuberculosis, pneumonia, and sarcoidosis were the ... | 1988 | 3068829 |
| an outbreak of disseminated aspergillosis associated with an intensive care unit. | 1988 | 3069301 | |
| pathologic, hematologic, and serologic changes in rabbits given t-2 mycotoxin orally and exposed to aerosols of aspergillus fumigatus conidia. | the influence of immunosuppression by t-2 mycotoxin on the fungal disease aspergillosis was investigated in rabbits. four groups of rabbits (groups 1a, 1b, 3a, and 3b) were given 0.5 mg of t-2 toxin/kg of body weight/day, po; in addition, rabbits of groups 3a and 3b were exposed to aerosols of aspergillus fumigatus conidia from days 7 through 16. rabbits of groups 2a and 2b were exposed to a fumigatus aerosols, but were not given t-2 toxin, and rabbits of group 0 served as controls. two rabbits ... | 1988 | 3071196 |
| binding of fibrinogen to the pathogenic aspergillus species. | the binding of human fibrinogen to the pathogenic aspergilli was investigated in vitro by different procedures using either fibrinogen in solution or fixed, insolubilized fibrinogen. binding of fibrinogen was detected at the surface of hyphae and conidia by an immunofluorescence assay. ultrastructural localization of the binding sites was visualized with fibrinogen-sensitized gold particles. the labelling was restricted to the outer cell wall layer of the 'smooth' walled conidia. quantitative an ... | 1988 | 3073204 |
| morphological studies on clinical isolates of aspergillus fumigatus. | morphological variation was examined in 19 strains of aspergillus fumigatus fres. isolated from the sputum of five patients with aspergilloma. for each patient a series of variant strains was obtained which exhibited gross differences in growth rate, colour and texture of the colony. on microscopical examination, some of the strains were found to produce markedly abnormal fruiting heads which were uncharacteristic for the species. scanning electron microscopy revealed that the variant produced c ... | 1988 | 3073205 |
| [biological activity of the soluble conidial proteins of aspergillus fumigatus fres. during germination]. | 1988 | 3074256 | |
| [toxigenicity and pathogenicity of micromycetes isolated from fish roe]. | 1988 | 3074261 | |
| invasive and granulomatous pulmonary aspergillosis with cerebral dissemination. | 1988 | 3075268 | |
| [invasive form of pulmonary aspergillosis in a patient with chronic lymphocytic leukemia successfully treated with amphotericin b]. | 1988 | 3075740 | |
| immunomodulation by candida albicans: crucial role of organ colonization and chronic infection with an attenuated agerminative strain of c. albicans for establishment of anti-infectious protection. | intravenous inoculation of an attenuated agerminative strain of candida albicans (pca-2) of low virulence, but not of two other species of candida of low virulence (c. parapsilosis and c. viswanathii) into cd2f1 mice conferred protection against the highly virulent microbes c. albicans ca-6, staphylococcus aureus and aspergillus fumigatus. to provide protection, a definite inoculum size (10(6) cells per mouse) resulting in organ colonization and establishment of a long-lasting chronic infection ... | 1988 | 3076189 |
| [pneumopathy caused by aspergillus in patients undergoing renal transplantation]. | 1988 | 3077208 | |
| [detection of specific antibodies in patients with aspergillosis using an immunoenzyme method]. | 1988 | 3077714 | |
| tremorgenic effects of mould extracts isolated in wood industry tested in rats. | 1988 | 3078625 | |
| prevention of airborne fungal infection in immunocompromised patients. | 1988 | 2896699 | |
| use of bronchoalveolar lavage in immunocompromised children with pneumonia. | because pneumonia in the immunocompromised host presents a diagnostic dilemma to the pediatrician, we prospectively studied the use of bronchoalveolar lavage (bal) with flexible fiberoptic bronchoscopy in 14 immunocompromised children with pneumonia over a 5-month period. the children received immunosuppressive agents because of organ transplants, cancer, or systemic lupus erythematosus. a diagnosis was made by bal in 10 (71%) of the 14 children. pathogenic organisms included pneumocystis carini ... | 1988 | 2845341 |
| simultaneous aspergillus endophthalmitis and cytomegalovirus retinitis after kidney transplantation. | we report a case of disseminated and intraocular aspergillus and cytomegalovirus (cmv) infection in a renal transplant recipient. aggressive management included reduction of the immunosuppressive medications, systemic and intraocular administration of antifungal agents, treatment with a systemic antiviral drug, and ophthalmic surgery. the clinical and histopathologic features of intraocular aspergillus and cytomegalovirus infections are discussed. the literature of intraocular mixed opportunisti ... | 1988 | 2852837 |
| studies on antifungal agents. 18. in vitro activity of 5,5-disubstituted-3-phenyl-3-(1h-imidazol-1-ylmethyl)-2-methy lisoxazol idines and related compounds. | the in vitro antifungal activity of a series of novel 5,5-disubstituted-3-phenyl-3-(1h-imidazol-1-ylmethyl)-2-methyli soxazolidines and related compounds against trichophyton rubrum, aspergillus fumigatus and candida albicans was studied. the screening was performed in solid agar cultures and some structure-activity relationships involving the c-5-substitution pattern are discussed. | 1988 | 2854041 |
| high-performance liquid chromatography of siderophores from fungi. | a reversed-phase hplc separation of iron(iii) chelates of 16 representative fungal siderophores including ferrichromes, coprogens and triacetylfusarinine c was established in order to investigate siderophore production of fungi. for comparison purposes, the widely used bacterial siderophore ferrioxamine b was included. culture filtrates of the fungi penicillium resticulosum, fusarium dimerum, aspergillus fumigatus and neurospora crassa were quantitatively analyzed for the presence of known and u ... | 1988 | 2978959 |
| localization, molecular weight and immunoglobulin subclass response to aspergillus fumigatus allergens in acute bronchopulmonary aspergillosis. | a specimen of aspergillus fumigatus was isolated from a patient with acute bronchopulmonary aspergillosis (abpa). cultures were allowed to propagate and were separated into spores and mycelium to greater than 95% homogeneity. extracts of both the spores and mycelium were prepared and used for study by both dot blot analysis and immunoblotting to study the major allergens. by dot blot analysis, 22 of 22 patients with abpa and none of 10 healthy controls reacted with mycelium when probed for both ... | 1988 | 2451644 |
| interferon inhibits aspergillus fumigatus growth in mice: an activity against an extracellular infection. | prophylactic treatment of mice with interferon (ifn) or polyinosinic-polycytidylic acid [poly(i:c)], an ifn inducer, provided significant protection against an extracellular infection by aspergillus fumigatus in both swiss and swiss athymic nude mice. tunicamycin (tm) treatment inhibits the antifungal activity of ifn and poly(i:c) in these mice. anti-asialo gm1 or tm [both inhibitors of natural killer (nk) cell function] treatment enhance the severity of a. fumigatus infection. these results sug ... | 1988 | 2452848 |
| histopathology of experimental aspergillus fumigatus keratitis. | histopathological studies in rabbit's eyes, 7 and 14 days after intracorneal inoculation with 1 x 10(5) aspergillus fumigatus conidia have been performed. similar lesions were found in both periods with fungal hyphae in the anterior third of corneal stroma, round cell infiltration from the sclero-corneal edge and in the anterior chamber and, neovascularization. no lesions were found in the descemet's membrane. gomori silver-methenamine stain with hematoxiline-eosine counter-stain was found to be ... | 1988 | 2454404 |
| the application of immunoperoxidase staining for the detection of causative fungi in tissue specimens of mycosis i. | this study was performed in order to identify the fungi of four species (aspergillus fumigatus, fusarium anthophilum, candida albicans, cryptococcus neoformans) in formalin-fixed, paraffin-embedded tissue sections by the indirect method of immunoperoxidase staining. mature albino rabbits were immunized by formalin-killed organisms. the antibodies were prepared by precipitation at a 50% saturation of ammonium sulfate and were checked for cross-reactivities by ouchterlony's double immunodiffusion ... | 1988 | 2457159 |
| ecological and physiological studies on fungi associated with human hair. | thirty-seven species attributed to 19 genera of keratinophilic fungi were recovered from 100 human hair samples collected from the assiut governorate. the genera aspergillus followed by penicillium and chrysosporium were frequently isolated from 65, 43 and 30% of the samples respectively. fifteen species and 13 genera of thermophilic and thermotolerant fungi (recovered at 45 degrees c) were identified. the thermotolerant aspergillus fumigatus was frequently encountered and emerged from 82% of th ... | 1988 | 2462534 |
| immunoblot fingerprinting aspergillus fumigatus. | a new technique for typing aspergillus fumigatus is presented. this is based on immunoblot fingerprinting each isolate against a rabbit hyperimmune antiserum raised against a. fumigatus nctc 2109. all isolates were typable and reproducibility for the 16 antigenic bands which formed the basis of the system was excellent. discrimination was better than silver staining and revealed 11 types among the 21 isolates from eight patients with an aspergilloma. each aspergilloma could be due to either a si ... | 1989 | 2466902 |
| production and characterization of murine monoclonal antibodies to histoplasma capsulatum yeast cell antigens. | four monoclonal antibodies (mabs) were produced by immunizing mice with a disrupted yeast cell homogenate of histoplasma capsulatum. mabs 1 and 2 reacted only with the yeast cell antigens of h. capsulatum and blastomyces dermatitidis, whereas mabs 3 and 4 showed broader cross-reactivity. mab 3 cross-reacted with b. dermatitidis, paracoccidioides brasiliensis, sporothrix schenckii, and candida albicans, and mab 4 cross-reacted with b. dermatitidis, c. albicans, coccidioides immitis, aspergillus f ... | 1989 | 2917790 |
| isolation of a mycotoxin (gliotoxin) from a bovine udder infected with aspergillus fumigatus. | a bovine udder infected with aspergillus fumigatus was analysed by physico-chemical methods (thin layer chromatography, high performance liquid chromatography and direct exposure probe-mass spectrometry) for the presence of mycotoxins. gliotoxin, a fungal metabolite with cytotoxic and immunosuppressive properties was isolated for the first time from naturally infected tissue. the gliotoxin concentration analysed (9.2 mg kg-1 udder) was approximately 100 times higher than the concentration known ... | 1989 | 2474066 |
| use of thin layer chromatography for detection and high performance liquid chromatography for quantitating gliotoxin from rice cultures of aspergillus fumigatus fresenius. | gliotoxin, a mycotoxin with antimicrobial and immunosuppressive capabilities, is produced by several genera of fungi including the pathogenic fungus aspergillus fumigatus. the ability of selected isolates of a. fumigatus to produce gliotoxin on three different media was tested and a thin layer chromatographic and high performance liquid chromatographic method for quantitation of gliotoxin from rice culture was developed and is described. rice cultures were extracted with chloroform and the resul ... | 1989 | 2482445 |
| intratracheal exposure of rats to aspergillus fumigatus spores isolated from sawmills in sweden. | five strains of aspergillus fumigatus (a, b, d, h, and k) isolated from sawmills were used to expose groups of three rats by intratracheal intubation. the dose was 10(9) spores per rat. at 48 h after administration, two rats from the d group and all rats from the k group died with symptoms of strong dyspnea and tachypnea. at 72 h postadministration and after, some animals showed mild to moderate dyspnea and tachypnea. autopsies of all animals were performed, including a histopathological examina ... | 1989 | 2483040 |
| [in vitro study of the antifungal activity of two chlorine derivatives to be used in antisepsis]. | the activity of two chlorine derivates, sodium hypochlorite in water solution with nacl (product a) and electrolytic chloroxidant (product b) has been tested in vitro against potentially human pathogenic fungi (aspergillus niger, aspergillus fumigatus, microsporum gypseum, candida albicans, cryptococcus neoformans, trichophyton mentagrophytes, microsporum canis, epidermophyton floccosum, trichophyton rubrum, sporotrix schenkii). for a. niger, the relation of the two compounds has also been consi ... | 1989 | 2483652 |
| incorporation of tellurium into amino acids and proteins in a tellurium-tolerant fungi. | aspergillus fumigatus, aspergillus terreus, and penicillium chrysogenum, a tellurium tolerant fungi, are able to grow on sulfur free medium amended with 0.2% (w/v) tellurite. tellurium was incorporated into several types of low and high molecular weight proteins. the newly detected telluro-proteins contained an extraordinary high level of tellurium, as well as telluro-cysteine, telluro-cystine, telluro-methionine, and serine. | 1989 | 2484755 |
| isolation of human pathogenic fungi from barbers' shop of chhindwara (mp): a preliminary study. | isolation of human pathogenic fungi was made from the barbers' shops of chhindwara. trichophyton mentagrophytes showed highest percentage of occurrence (30%), followed by trichophyton rubrum (26%) and aspergillus fumigatus (18%) whereas, the lowest relative density was exhibited by aspergillus niger and a hyphomycetous fungus (2%). | 1989 | 2486270 |
| neuropathology of pediatric liver transplantation. | we reviewed the clinical histories and autopsy records of 35 pediatric patients (ranging in age from 9 months to 18 years) who underwent orthotopic liver transplantation using ciclosporin and corticosteroids for immunosuppression. at the time of death, 19 children (54%) had encephalopathy, 16 (46%) were lethargic or in coma, 10 (29%) had seizures, and 10 were normal. neuropathological lesions were found on postmortem examination in all 35 patients. vascular lesions such as infarction, ischemia, ... | 1989 | 2489584 |
| aspergillus infection in the neutropenic host. | 1989 | 2498353 | |
| increased amounts of the aspergillus metabolite d-mannitol in tissue and serum of rats with experimental aspergillosis. | several aspergillus species produce large amounts of the hexitol d-mannitol in vitro, but it is not known whether these species also produce d-mannitol in vivo. serum samples and homogenized tissues were analyzed from rats pretreated with cortisone and cyclophosphamide and then given 2 x 10(6) preincubated conidia of aspergillus fumigatus intravenously. the resulting infection was lethal by 48 h and was characterized by much more severe disease in the liver than in the kidneys, spleen, or lungs. ... | 1989 | 2499640 |
| efficacy of immunoprecipitation methods for rapid serodiagnosis of allergic bronchopulmonary aspergillosis. | the relative efficacy of ouchterlony's double diffusion (odd), wadsworth's gel diffusion (wgd) and counter-immunoelectrophoresis (cie) is reported for serodiagnosis of allergic bronchopulmonary aspergillosis (abpa). of the 50 sera taken from patients with confirmed or suspected abpa, serum precipitins were demonstrated against aspergillus fumigatus by cie, wgd and odd in sera from 34, 31 and 25 patients, respectively. the results were negative by the three methods in sera taken from 10 healthy v ... | 1989 | 2499786 |
| ct findings in sphenoid sinus aspergillosis. | 1989 | 2501737 | |
| indolinone derivatives as potential antimicrobial agents. | 1-substituted aminomethyl-3-cyclohexylthiosemicarbazone-2-indolinones (i) were tested for their antibacterial activity against bacillus pumilis, bacillus brevis and bacillus megaterium and antifungal activity against aspergillus flavus, aspergillus fumigatus and aspergillus niger. the majority of the compounds were found to exhibit promising antibacterial and antifungal activities. these compounds were also screened for their antiviral action against tobacco mosaic virus in nicotiana glutinosa p ... | 1989 | 2501946 |
| the radiographic appearances of infection and acute rejection of the lung after heart-lung transplantation. | thirty-two patients underwent combined heart and lung transplantation at papworth hospital between 1984 and 1987. the clinical and physiologic observations made at the time of episodes of infection and rejection together with the histopathology of lung tissue obtained by transbronchial lung biopsy were compared with pre- and postepisode chest radiographs. there were 45 episodes of rejection in 20 patients: 23 episodes during the first month after transplantation, and 22 after 1 month. twenty-six ... | 1989 | 2502057 |
| aspergillosis. | aspergillus spores are ubiquitous in the environment and may become concentrated in hospital ventilation systems. colonization in normal hosts can lead to allergic diseases ranging from asthma to allergic bronchopulmonary aspergillosis. normal hosts rarely develop invasive disease, which is primarily an infection of severely immunocompromised patients. the major predisposing factors for infection include prolonged neutropenia, chronic administration of adrenal corticosteroids, the insertion of p ... | 1989 | 2502407 |
| immunofluorescence staining of hyphae in the histopathological diagnosis of mycoses in cattle. | an immunofluorescence staining system was developed for the identification of mycelial fungi causing systemic mycoses in cattle. antisera to absidia corymbifera, aspergillus fumigatus, aspergillus flavus, and aspergillus niger were raised in rabbits. tissue sections of experimentally infected mice were used to determine the specificity of immune staining with antisera that had been absorbed with heterologous antigens. when 46 lesions from 22 cattle with systemic mycosis were studied, the infecti ... | 1989 | 2502614 |
| biocidal activity of ozone versus formaldehyde against poultry pathogens inoculated in a prototype setter. | ozone was evaluated as an alternative hatchery disinfectant to replace formaldehyde in the event that the environmental protection agency regulates the use of formaldehyde under the toxic substances control act. cultures of staphylococcus, streptococcus, and bacillus species previously isolated from poultry hatcheries and selected culture collections of escherichia coli, pseudomonas fluorescences, salmonella typhimurium, proteus species, and aspergillus fumigatus were spread-plated on open petri ... | 1989 | 2506541 |
| pulmonary and myocardial infarction secondary to arterial occlusion by aspergillus fumigatus in anll. | secondary invasive aspergillosis is a well-recognized complication of the immunocompromised patient. this case concerned a 52-y.o. male patient affected by anll (fab: m2). on day 10 after induction therapy the patient, previously apyretic and asymptomatic, had an episode of acute dyspnea with fever (39 degrees c). chest x-ray and pulmonary scintigram were compatible with a diagnosis of pulmonary embolism, and the patient was started on heparin. on day 24 the patient had persistent anginal pain w ... | 1989 | 2511122 |
| comparison of immunodiffusion and enzyme linked immunosorbent assay for antibodies to four aspergillus species. | antigenic extracts were prepared from aspergillus fumigatus, a niger, a flavus and a terreus for use in enzyme linked immunosorbent assay (elisa) and immunodiffusion (id) tests for aspergillus antibodies to determine whether the use of antigenic extracts from species other than a fumigatus increased the sensitivity of the elisa. elisa titres correlated well with positive id tests. patient titres by elisa were significantly higher than control titres for all species. patient titres to a niger wer ... | 1989 | 2511230 |