Publications

herpesvirus-associated epidermal hyperplasia in fish (carp).		1978	751904
on the etiological role of herpesvirus ovis in jaagsiekte.	serologically related ovine herpesviruses have been isolated independently by various workers in different countries from adenomatous lung tissue of sheep or cell cultures derived from it. although the disease can be transmitted with lung homogenates and with cell cultures, transmission attempts with virus alone failed. iudr treatment of tumour-cell cultures and co-cultivation or fusion with cells permissive for virus replication induced antigens which react with some sera from tumour-bearing an ...	1978	751905
phosphonoacetic acid in the treatment of simian varicella.	phosphonoacetic acid inhibited replication of simian varicella virus (delta herpesvirus) in tissue culture. the drug was tested in patas monkeys 40 h after infection with delta herpesvirus. a total of 200 mg/kg per day was given intramuscularly, divided into two doses every day for a total of 10 days. the treated monkeys were protected from clinical illness, and delta herpesvirus was not recovered from their lymphocytes. complement-fixing and neutralizing antibody titers were significantly lower ...	1978	213014
therapeutic effect of trisodium phosphonoformate on cutaneous herpesvirus infection in guinea pigs.	when applied topically, trisodium phosphonoformate (pfa) displayed activity against established cutaneous herpesvirus infections in guinea pigs similar to that exhibited by the closely related phosphonoacetic acid (paa); however, unlike paa, pfa was not locally skin irritating. the therapeutic benefits of topical application of pfa were clearly evident when application was delayed for 48 h after virus inoculation, at which time lesions were well developed. the therapeutic effect was dependent on ...	1978	213015
widespread occurrence in australian marsupials of neutralizing antibodies to a herpesvirus from a parma wallaby.	serum neutralizing antibodies to a parma wallaby herpesvirus (pwhv) have been detected in a wide range of marsupials from different locations across australia, including several islands. a study of 242 animals (mostly macropods) sampled in the wild showed that 23% had antibodies; a significantly higher frequency (41%) of 116 animals in captivity had antibodies, which were generally at higher levels than those of animals in the wild. antibodies to pwhv were also detected among parma wallabies fro ...	1978	213046
augmentation of the in vitro mitogenic response of owl monkey peripheral blood lymphocytes by levamisole and loss of this effect with the development of herpesvirus saimiri-induced lymphoma.	levamisole (lms) has been shown to be capable of enhancing the proliferative response of normal owl monkey peripheral blood lymphocytes (pbl) to pha, and, to a lesser degree, of increasing the level of spontaneous dna synthesis. with the development of herpesvirus saimiri-induced lymphoma, these stimulatory responses were lost. lms was not capable of stimulating tumour cells to normal functions, or of reversing the disease-induced suppressed functions on normal cells.	1978	213219
serological reactivities of human and baboon sera against ebna and herpesvirus papio-determined nuclear antigen (hupna).		1978	213288
development of cell-mediated immunity to marek's disease tumor cells in chickens inoculated with marek's disease vaccines.	chickens inoculated with herpesvirus of turkeys or with apathogenic or attenuated vaccine strains of marek's disease virus (mdv) developed a t-cell-mediated immune response to marek's disease (md) tumor cells. this immune response was detected in a 4-hour 51cr-release assay in which effector cells obtained from spleens of vaccinated chickens were reacted with 51cr-labeled target cells of an md lymphoblastoid cell line (msb-1). the cytotoxic effector cells generated by the vaccine viruses had cha ...	1978	213610
rapid diagnosis of cytomegalovirus infection in infants by electron microscopy.	electron microscopy was applied to the diagnosis of cytomegalovirus infection in infants; we used the pseudoreplica method, which permits detection of herpesvirus particles within 15 to 30 minutes. viruses were most readily detectable in urines with infectivity titers greater than or equal to 10(4) per milliliter (95 per cent correlation with the tissue-culture method). virus particles were detected in 18 of 20 urines obtained from symptomatic or asymptomatic, congenitally or postnatally acquire ...	1978	213712
decreased antiviral effect of phosphonoacetic acid on the poikilothermic herpesvirus of channel catfish disease.		1978	213781
intranasal tumor of the ethmoid olfactory mucosa in sheep.	intranasal tumors (papillary adenomas or adenocarcinomas) of the ethmoid olfactory mucosa of sheep were investigated by light and electron microscopy. the fine structure of the tumor cells was characterized by the presence of numerous secretory granules. viral particles, which were morphologically similar to a visna-maedi virus, were detected in all tumor tissues and in 3 of 4 cultures examined. the particles (about 97 nm) had an eccentrically located electron-dense core and numerous spikes on t ...	1978	213993
herpesvirus.		1978	214731
[antiviral activity of phenolic polymers against type 1 herpesvirus hominis].		1978	214800
induction of deoxythymidine kinase activity in several mammalian cell lines after infection with six different strains of equine herpesvirus type 1 (ehv-1).		1978	214953
[demonstration of bovine herpesvirus 1 (ibr/ipv) in cattle with gastrointestinal diseases].		1978	215117
biological properties of equine herpesvirus type 1 dna: transfectivity and transforming capacity.	dna extracted from purified virions of equine herpesvirus type 1 (ehv-1) was examined for its transfectivity and transforming ability. the infectivity of the herpesvirus dna was demonstrated by addition of calcium phosphate-dna coprecipitates to monolayers of permissive horse cells, with resultant plaque formation. the efficiency of transfection (50 to 100 plaque-forming units/microgram of dna) was reduced by treatment of the viral dna with deoxyribonuclease or sonication but not with pronase o ...	1978	215545
treatment of genital herpes simplex virus infection with photodynamic inactivation.	a double-blind randomized study to evaluate the effect of proflavine in the treatment of genital herpesvirus infection was conducted. one hundred fifty-seven women were studied, of whom 75 were treated with proflavine (treated women) and 82 were treated with placebo (control group). there were 62 women with primary disease and 95 with recurrent infection. under the conditions by which this study was conducted, there was no apparent difference in the time of healing of lesions, development of rec ...	1978	216264
[incidence and prevalence of antibodies to measles, herpesvirus infections, mumps and rubella in the cerebrospinal fluid and serum of subjects with abiotrophic-degenerative type diseases of the central nervous system].		1978	216379
toxoplasmosis, distemper, and herpesvirus infection in a skunk (mephitis mephitis).	a striped skunk (mephitis mephitis) showing abnormal behavior had histopathologic lesions of toxoplasmosis and canine distemper in addition to intranuclear, eosinophilic inclusions in the reticuloendothelial cells of the spleen, liver and lung. the inclusions, on electron microscopic examination, were compatible with herpesvirus infection.	1978	204802
persisting oncogenic herpesvirus induced by the tumour promotor tpa.		1978	204874
the fate of parental herpesvirus dna after infection with normal and photoinactivated virions.	the fate of the 3h-dt-labelled parental dna of normal and photoinactivated herpes simplex virus type 1 (kos strain) was followed for 8 h after infection. the sedimentation coefficients of parental virus dna from cells infected with normal virons increased and became associated with the replicative intermediates of hsv-1 dna. when cultured in 5-bromodeoxyuridine-containing medium, the buoyant density of the normal parental virus dna shifted to the hybrid region (containing heavy and light molecul ...	1978	205628
solubilization and characterization of herpesvirus saimiri-induced membrane antigens.	treatment of herpesvirus saimiri (hvs)-infected owl monkey cells by limited papain digestion removed the hvs-induced membrane antigen (ma) as determined by membrane immunofluorescence and antibody-dependent lymphocyte cytotoxicity (adlc). soluble antigenically active hvsma was detected by inhibition of adlc and by the decreased binding of 125i-labeled staphylococcus protein a to hvs-infected cells after absorption of an anti-ma-positive serum with papain extracts. approximately 38% of the inhibi ...	1978	205674
acute pharyngotonsillitis caused by herpesvirus type 2.		1978	205688
susceptibility of marmosets to epstein-barr virus-like baboon herpesviruses.	epstein-barr virus (ebv)-like herpeviruses, strains of herpesvirus papio (hvp), have recently been isolated from lymphomatous (hvp-l) and from normal baboons (hvp-n). both hvp isolates infect some species of marmosets, hvp-l inoculated adult animals develop a mild to severe and sometimes fatal lymphoproliferative disease whereas newborn marmosets of the same species do not develop a measureable disease after inoculation with hvp-l. hvp-n infects adult marmosets but does not cause disease.	1978	205854
spontaneous infectious diseases of marmosets.	the various species of marmosets are susceptible to a wide variety of infectious agents of which only a few have been fully characterized. little is known concerning spontaneous disease in their natural habitat, and often deaths in the laboratory go unexplained. in captivity, herpesvirus-t infection appears to be the most important viral infection, but serious disease may also follow infection with measles virus (rubeola) and an unidentified paramyxovirus. bacterial diseases are multiple, but ra ...	1978	205855
transfer factor and its protective effect against herpesvirus infections of marmosets.	using skin test response and lymphocyte blastogenesis as indicators of cell-mediated immunity, we have been able to demonstrate in vivo transfer of cell-mediated immunity to marmosets both with dialyzable transfer factor (tfd) prepared from a human donor and transfer factor (tf) from baboon whole cell lysates. we were able to protect marmosets with tfd from fatal herpesvirus hominis type 1 (hvh-1) disease. when tfd was administered prior to challenge with hvh-1, 50% of the marmosets survived. of ...	1978	205856
epidemiological approaches to determining whether herpesvirus is the etiological agent of cervical cancer.		1978	205907
inactivation of clinical isolates of herpesvirus hominis, types 1 and 2, by chemical contraceptives.	two chemical contraceptives were examined for virucidal effects against four strains each of herpesvirus hominis, type 2 and 1. seven of the strains represented recent clinical isolates; one strain was a type 2 prototype. either psermicide reduced the infectivities ofall eight viruses after contact for 10 minutes at room or body temperature. the new spermicide-germicide, compound a, produced an antiviral effect at the low concentration of 0.05%, whereas the commercially available preceptin was e ...	1978	205958
regulation of herpesvirus macromolecular synthesis. vii. inhibition of internal methylation of mrna late in infection.		1978	205998
[mechanism of specific vaccine therapy in ocular herpes simplex].	the mechanism of specific vaccine therapy in herpetic eye disease was studied. the effectiveness of the therapy in the observation period of 3 to 8 years was established. in 71 (62%) of 114 patients relapses of the disease disappeared completely, in 32 (26%) became less frequent and in 11 (10%) their frequency did not change. the clinical course of relapses in all cases became milder. the vaccination courses given were shown not to influence the level of virusneutralizing antibody but to induce ...	1978	206026
inhibition of herpesvirus replication and herpesvirus-induced deoxyribonucleic acid polymerase by phosphonoformate.	phosphonoformate was found to be an inhibitor of the deoxyribonucleic acid polymerase induced by the herpesvirus of turkeys. the apparent inhibition constants were 1 to 3 mum. phosphonoformate was also able to block the replication in cell culture of marek's disease herpesvirus, the herpesvirus of turkeys, and herpes simplex virus. it was as effective as phosphonoacetate. phosphonoformate was not an effective inhibitor of a phosphonoacetate-resistant mutant of the herpesvirus of turkeys nor of i ...	1978	206200
an improved method for extracting cell-free herpesviruses of marek's disease and turkeys from infected cell cultures.	sonic extraction of cell-free marek's disease herpesvirus (mdhv) and turkey herpesvirus (hvt) from infected cell cultures was improved by incorporating sorbitol in the suspending media. yields of cell-free virus of virulent mdhv were significantly increased with 10% sorbitol added to spga-edta buffer. avirulent strains of mdhv and hvt were respectively readily extracted with spga-edta and spga as the suspending medium, and extraction of their cell-free viruses was moderately improved by adding s ...	1978	206250
effect of treatment with exogenous interferon, polyriboinosinic-polyribocytidylic acid, or polyriboinosinic-polyribocytidylic acid-poly-l-lysine complex on herpesvirus hominis infections in mice.	the effect of treatment with exogenous interferon was compared with those of two interferon inducers, polyriboinosinic-polyribocytidylic acid [poly(i) . poly(c)] and poly(i) . poly(c)-poly-l-lysine complex [poly(iclc)], in three model herpesvirus hominis type 2 infections of mice. after intraperitoneal inoculation of h. hominis type 2, all drugs significantly protected animals against death and increased the mean day of death when administered as late as 48 hr after viral inoculation. with intra ...	1978	206632
viral inclusions in raccoon liver cells.	three young raccoons (procyon lotor), two from michigan and one from arizona, died suddenly from acute infections. intranuclear inclusion bodies and viral particles typical of herpesvirus were seen in liver cells from all three. inclusions also were seen in the nuclei of endothelial cells in the lung, liver, glomeruli and reticuloendothelial cells of the spleen. the source of the infection was not determined, but possible transmission from other species could not be ruled out.	1978	206734
[mixed herpesvirus and bacterial sensitization in uveitis].		1978	207000
[electron microscopy studies on the multiplication of herpesvirus-equi-1 in brain cells of hamsters].		1978	207056
isolation of equine herpesvirus type 2 from foals, showing respiratory symptoms.		1978	207057
expression of herpesvirus in adherent cells derived from bone marrow of latently infected guinea pigs.	the role of bone marrow adherent cells in the latency of guinea pig herpes-like virus (gphlv) was explored. cultures of macrophage-enriched adherent cells derived from infected guinea pigs were examined for evidence of latent gphlv infection. expression of the virus was detected in these cultures 9 to 10 days after in vitro cultivation. increasing virus infectivity titers as well as light and electron microscopic evidence of virion assembly in macrophages and fibroblasts were demonstrated. infec ...	1978	207189
measurement of neutralizing antibody to equid herpesvirus 1 by single radial hemolysis.	antibody to equid herpesvirus 1, which mediates single radial hemolysis, is that responsible for neutralization. hemagglutination inhibition antibody is not necessarily involved in neutralization or hemolysis.	1978	207720
flow microfluorometric analysis of herpesvirus infected bhk-21 and balb/3t3 cell cultures.	the interaction of herpes simplex type 1 with two eukaryotic cell lines (bhk-21 and balb/3t3) was investigated by flow microfluorometric analysis after cell staining with mithramycin. uninfected, lytically infected and persistently infected cell populations were examined. viral replication within an infected cell population could be detected via fmf analysis. the low levels of viral replication occurring within persistently infected cell populations were also detectable. a marked degree of corre ...	1978	207772
susceptibility of human embryonic kidneys in organ culture to herpesvirus hominis.	101 pairs of human embryonic kidneys of 5-12 weeks' gestation were maintained in whole organ culture by our previously described technique, with herpesvirus hominis types1 and 2 added to our regular media. one kidney of each pair served as a control and was exposed to identical culture medium without virus. cultures were maintained for 24-120 h to study the time sequence of viral infectivity. organs were then examined for the presence of virus by electron microscopy and histochemical staining. h ...	1978	208015
relation of herpesvirus hominis type ii to carcinoma of the cervix. an animal model for the induction of long-term latency of herpesvirus hominis type ii.	proof of latency of herpesvirus hominis type ii (hvh-ii) following acute vaginocervical infection must be validated if it is to be considered an etiologic factor in carcinoma of the cervix. an animal model is presented which demonstrates acute hvh-ii vaginocervical infection. following the primary acute infection, animals maintained for an equivalent of 60 human years display persistance of the herpesvirus in the pelvic sensory ganglia. evidence of the specificity of hvh-ii as the infectious age ...	1978	208035
direct evidence for 6-fold symmetry of the herpesvirus hexon capsomere.	rotational power spectrum analysis of scanning transmission electron micrographs of negatively stained herpesvirus capsids has given direct evidence for the 6-fold symmetry of the herpesvirus hexon capsomere. individual hexons have been analyzed in situ without interference from other parts of the capsid because only one level of the capsid was in focus in the micrograph. this study found hexons to have 6-fold symmetry. the majority of the mass of each hexon subunit was seen to lie on a line con ...	1978	208076
antibody to bovid herpesvirus 2 in the sera from cattle in the netherlands.		1978	208225
distribution of bovid herpesvirus 2 in calves inoculated intravenously.	the behavior of bovid herpesvirus 2 in the skin, lymph nodes, and nervous system of calves injected intravenously with the virus was studied. after a latent phase that lasted up to 40 hours after inoculation, the virus produced a systemic infection which was characterized by primary localization of virus in the skin, lymph nodes, and nervous system. between postinoculation days 7 and 12, the infection tended to persist in the skin only. the finding of intranuclear inclusions in the pyramidal cel ...	1978	208435
pathogenesis of marek's disease in chickens with maternal antibody.	histopathological lesions were studied in chickens with maternal antibody against md virus at 14-day intervals after their exposure by contact to hprs-16 of md virus in the first-day of life. the first lesions occured 14 days after infection in the liver, kidney, heart, brain and the sciatic nerves. relatively, the most expressive changes were observed between 56th and 70th day after infection. lesions were characterized as light to heavy infiltrations formed by immature and mature pleomorphic m ...	1978	208481
syncytium formation caused by human cytomegalovirus in human embryonic lung fibroblasts.	large syncytia were regularly produced after prolonged infection in vitro of human embryonic fibroblasts by ad169 and other strains of human cmv. the syncytia showed typical cmv intranuclear inclusion bodies and herpesvirus particles in the nuclei and cytoplasm. it is proposed that syncytium formation follows abortive infection of the fibroblasts with defective virus.	1978	208487
experimental infection of callithrix jacchus marmosets with herpesvirus ateles, herpesvirus saimiri, and epstein barr virus.	we inoculated common marmosets (callithrix jacchus) with herpesvirus ateles (hva), herpesvirus saimiri (hvs), and epstein-barr virus (ebv). hva-induced tumors contained several cell types, including giant cells reminiscent of the sternberg-reed cells observed in human hodgkin's disease. hvs and ebv did not induce tumors, although hvs was present in lymphocytes and elicited a strong antibody response. ebv elicited only a variable antibody response. we feel that more common marmosets should be use ...	1978	208678
response of the respiratory tract of calves kept at controlled climatic conditions to bovine herpesvirus 1 in aerosol.	seven experiments with four calves each were conducted in which the calves spent at least four days of adaptation in an environmental chamber and then were subjected to climatic stress in the form of a number of constant ambient temperature and humidity combinations. on the second day of climatic stress the calves were individually exposed to measured numbers of infectious units of bovine herpesvirus 1 (bhv1, virus of infectious bovine rhinotrachetis) in aerosol. the calves were killed seven or ...	1978	208734
the protective antigens of equine herpesvirus type 1.	equine herpesvirus type 1 was cultivated in swine testis cell cultures and partially purified by differential centrifugation and centrifugation in a linear sucrose density gradient. the viral envelope was separated from the nucleocapsid by treatment with rexol 25j followed by sucrose gradient centrifugation. the envelope and nucleocapsid preparations were then electrophoresed in polyacrylamide gel after solubilization with sodium dodecyl sulphate. hamsters were immunized with various preparation ...	1978	208736
cytologic examination and viral and bacterial culture in herpes simplex, herpes zoster, and varicella.	cytologic examination of epithelial cells from the base of vesicles, virus isolation, and bacterial culture were carried out in thirty-one patients with herpes simplex, in eleven patients with herpes zoster, and in three patients with varicella. determination of herpes simplex complement fixation reaction was made in the patients with herpes simplex. cytologic manifestations consistent with herpes were found 65 percent of patients with herpes simplex, while herpesvirus hominis was isolated in 77 ...	1978	208820
stimulation of chicken spleen cell mitogenic response with turkey herpesvirus vaccine against marek's disease.		1978	208875
small-plaque variant of canine herpesvirus with reduced pathogenicity for newborn pups.	the plaque characteristics of 13 field isolates of canine herpesvirus were found to be similar. after 312 passages of the f-205 strain in dog kidney cell cultures incubated at 35 degrees c, the virus still was virulent for newborn pups; it also had the macroplaque morphology of the wild-type virus. however, after 20 additional passages at 30 degrees c, a microplaque (mp) variant had emerged as the predominant type. cloned mp virus retained the small-plaque characteristic after 66 transfers at 30 ...	1978	208969
in vitro establishment of marek's disease herpesvirus-transformed productive and nonproductive lymphoblastoid cell lines.	the establishment of two marek's disease herpesvirus-transformed lymphoblastoid cell lines (jmv-1 and jm-1) is reported. cocultivation with chicken embryo fibroblasts, attempts to rescue marek's disease virus from kidney cell cultures, and immunofluorescent staining show that jmv-1 is a nonproductive line and jm-1 is a productive line.	1978	208974
further characterization of a herpesvirus-positive orang-utan cell line and comparative aspects of in vitro transformation with lymphotropic old world primate herpesviruses.	an orang-utan (pongo pygmaeus) suspension line, cp81, was shown to lack myeloid markers of lysozyme activity an d phagocytosis but to be positive for lymphocytic n-alkaline phosphatase activity, and to release a b-cell-tropic herpesvirus. this herpesvirus, termed herpesvirus pongo, had 30--40% dna homology with ebv and was present at 2-3 genome copies per cp-81 cell. gibbon lymphocytes transformed by h. pongo, epstein-barr virus (ebv), and h. papio (of baboon, papio hamadryas, origin) were found ...	1978	208990
naturally occurring canine herpesvirus infection in japan.		1978	209235
the effect of herpesvirus infection and 2-deoxy-d-glucose on glycosphingolipids in bhk-21 cells.		1978	209617
recurrent genital herpes among women: symptomatic v. asymptomatic viral shedding.	to investigate whether asymptomatic shedding of herpes simplex virus occurs in women with recurrent genital herpes, six women with documented disease were followed up twice weekly with viral cultures and pelvic examination. during the study period of 1330 patient days and 452 patient visits, 26 episodes of genital herpesvirus infection were recorded. twenty-three (88%) episodes were accompanied by signs and symptoms. three (14%) of the culture-positive recurrences were asymptomatic. in one episo ...	1978	209847
effect of maternal antibody on viraemic and antibody responses to cell-associated and cell-free turkey herpesvirus in chickens.		1978	209848
antigen-inducing ability of herpesvirus papio in human and baboon lymphoma lines, compared to epstein-barr virus.	herpesvirus papio(hvp)-carrying baboon lymphoblastoid lines do not express a nuclear antigen like the epstein-barr virus(ebv)-determined nuclear antigen (ebna), as judged by in situ anticomplement fluorescence staining, although the carry multiple viral genomes and, in the case of producerlines, early antigen (ea) and viral capsid antigen (vca) that cross-react with the corresponding human ebv-determined antigens. to test whether the lack of in situ nuclear antigen expression is a property innat ...	1978	210135
herpesvirus morphology: visualization of a structural subunit.	the presence of spontaneously disrupted cytomegalovirus capsids has made it possible to visualize a subunit within the herpesvirus capsomere. the pattern resolved agreed well with the theoretical net based on the concept of a structural subunit at each apex of the hexon.	1978	210144
trisodium phosphonoformate, a new antiviral compound.	trisodium phosphonoformate selectively inhibits cell-free dna polymerase activity induced by herpesvirus. the new inhibitor has an antiviral effect on herpes simplex virus types 1 and 2, pseudorables virus, and infectious bovine rhinotracheitis virus in cell culture. it has a good therapeutic activity against cutaneous herpes simplex virus infection in guinea pigs.	1978	210500
perinatal foal mortality associated with a herpesvirus.	an outbreak of perinatal foal mortality associated with a herpesvirus is described. twenty two foals either were still-born, or died soon after birth, or were weak and soon developed severe respiratory signs, or were normal at birth and developed respiratory symptoms 18 to 24 hours later. elevated temperatures, heart and respiratory rates were constant features. the animals were severely leucopaenic, and showed an absolute neutropaenia. at autopsy the lungs were enlarged, and showed varying degr ...	1978	210751
equine abortion associated with herpesvirus.		1978	210753
pneumonia in calves produced with aerosols of bovine herpesvirus 1 and pasteurella haemolytica.	in each of 11 experiments, four calves were exposed first to an aerosol of bovine herpesvirus 1 (bhv1, virus of infectious bovine rhinotracheitis) and second to an aerosol of pasteurella haemolytica. the interval between aerosols was three to five days. in two other experiments, calves were exposed only to a bacterial aerosol. climate was controlled for all experiments from the day of viral exposure and for eight of the experiments it was also controlled for four to six days before the first aer ...	1978	210912
proctitis associated with herpesvirus hominis type 2 infection.		1978	210921
suppression and enhancement of mitogen response in chickens infected with marek's disease virus and the herpesvirus of turkeys.	the kinetics of phytohemagglutinin (pha) response of peripheral blood lymphocytes from chickens infected with oncogenic marek's disease (md) virus (mdv) or nononcogenic herpesvirus of turkeys (hvt) was studied with a whole blood microassay. at about 7 days after inoculation, a depression in pha response was observed in mdv-inoculated resistant line n or susceptible line 7(2) chickens and in hvt-inoculated line 7(2) chickens. all chickens initially regained their pha responsiveness. susceptible c ...	1978	211085
demonstration of marek's disease tumor-associated surface antigen in chickens infected with nononcogenic marek's disease virus and herpesvirus of turkeys.	the presence of marek's disease tumor-associated surface antigen (matsa) was demonstrated on spleen cells from p-line chickens inoculated 5--6 days earlier with herpesvirus of turkeys and sb-1 (a nononcogenic marek's disease virus). antisera against matsa expressed on five marek's disease lymphoblastoid cell lines were able to recognize the matsa present on sb-1-infected spleen cells. no viral membrane antigens and only a low incidence of viral internal antigens could be demonstrated.	1978	211242
herpesvirus infection modifies adenovirus rna metabolism in adenovirus type 5-transformed cells.	the effect of herpes simplex virus (hsv) infection of mrna metabolism was examined in a system where the fate of specific rna sequence can be assayed. adenovirus type 5-transformed rat embryo cell line 107 synthesizes adenovirus-specific rna (ad-rna), which functions in the cytoplasm as mrna. we have utilized ad-rna as a model for mrna metabolism, and in a preliminiary study we characterized ad-rna in the nucleus and cytoplasm by hybridization to filter-bound adenovirus dna. the results indicate ...	1978	211246
anatomy of bovine mammillitis dna ii. size and arrangements of the deoxynucleotide sequences.	we previously reported that bovine mammillitis virus (bmv) dna consists of two covalently linked components designated l and s and estimated to be 71.5 x 10(6) and 15.7 x 10(6) in molecular weight, respectively; the components invert relative to each other, giving rise to four equimolar populations differing soley in the relative orientation of the two components. we now report that (i) bmv dna has a contour length corresponding to a molecular weight of 89 x 10(6). (ii) component l consists of a ...	1978	211253
dna viruses in urine after renal transplantation.	approximately 2 500 specimens from 96 renal transplant recipients were examined for virus particles. electron microscopy of negatively stained preparations showed that only 3 virus groups were present, namely polyomavirus, adenovirus and herpesvirus. no rna viruses or oncogenic rna viruses (retraviridae) were detected. over a 5-year period polyomavirus was excreted by 37,5% of patients. both herpesvirus and adenovirus were excreted by approximately 11% of the patients. although trace quantities ...	1978	211648
skin hypersensitivity to equid herpesvirus type 1 in horses.		1978	211756
duration of vaccinal immunity against marek's disease.	specific vaccinal immunity against marek's disease (md) virus was measured by a short-term challenge test in which chickens vaccinated with turkey herpesvirus (hvt) and control chickens at various ages up to 40 weeks were inoculated with virulent md virus and evaluated 2 weeks later for microscopic lesions and md viremia. vaccinal immunity induced by high (2,900 pfu) and low (29 pfu) doses of hvt persisted without detectable reduction through the 40th week in line 151 chickens, thus indicating t ...	1978	211999
identification of a herpesvirus isolated from cytomegalovirus-transformed human cells.	human cells transformed by cytomegalovirus and transplanted to athymic nude mice yielded a cytopathic virus, hershey medical center virus, following prolonged in vitro passage of the tumor cells. the virus is a double-enveloped herpesvirus, is sensitive to ether, and is inhibited by iododeoxyuridine. no significant antigenic relationship to herpes simplex virus was detected using herpes simplex virus-immune sera in neutralization and immunofluorescence tests, but indirect immunofluorescence test ...	1978	212591
biochemical transformation of deoxythymidine kinase-deficient mouse cells with uv-irradiated equine herpesvirus type 1.	a line of 3t3 mouse cells lacking deoxythymidine kinase (dtk-) was stably transformed to the dtk+ phenotype after exposure to uv-irradiated equine herpesvirus type 1 (ehv-1). biochemical transformants were isolated in a system selective for the dtk+ phenotype (eagle minimal essential medium containing 10(-4) m hypoxanthine, 6 x 10(-7) m aminopterin, and 2 x 10(-5) m deoxythymidine). transformation was accompanied by the acquisition of a dtk activity with immunological, electrophoretic, and bioch ...	1978	212607
isolation of a herpesvirus-specific dna polymerase from tissues of an american patient with burkitt lymphoma.	a dna polymerase (dna nucleotidyltransferase) has been partially purified from a neck mass of an american patient with burkitt lymphoma and separated from the cellular dna polymerases. the molecular weight of the enzyme was approximately 90,000. the enzyme differs from the cellular dna polymerases, but resembles herpes-virus-induced dna polymerase in its primer template preference, high monovalent cation requirement for activity, and sensitivity to phosphonoacetate. enzyme activity was inhibited ...	1978	212756
activation of endogenous type c virus in balb/c mouse cells by herpesvirus dna.	several virion and nonvirion dnas were tested for the ability to activate endogenous type c virus in balb/c-derived mouse cells using the calcium precipitation technique. the dnas from all herpesviruses tested activated xenotropic type c virus synthesis. these included dnas from herpes simplex virus types 1 and 2, epstein-barr virus, human cytomegalovirus, sa8 virus, infectious bovine rhinotracheitis virus, pseudorabies virus, and herpes saimiri virus (m-dna). in contrast, dnas from vaccinia vir ...	1978	212761
episomal viral dna in herpesvirus saimiri-transformed lymphoid cell lines.	structural analysis of episomal viral genomes from two herpesvirus saimiri (hvs)-transformed tumour cell lines (no. 1670 and 70n2) showed that both types of episomes have a higher molecular weight than linear virion dna. the arrangement of unique (l) and repetitive (h) dna in no. 1670 episomes was studied by partial denaturation mapping. part of the l-sequences present in linear virion dna was found to be missing, part was found to be duplicated in the episomes. the episomal l-dna regions were c ...	1978	221324
herpesvirus papio: state of viral dna in baboon lymphoblastoid cell lines.	baboon lymphoblastoid cell lines (lcl) transformed with herpesvirus papio were evaluated for the state of hvp dna in the cells by caesium chloride density-gradient centrifugation and dna-crna filter hybridization. five hvp producer cultures and one non-producer culture were studied and non-integrated and integrated hvp dna were detected in all producer cultures whereas only integrated hvp dna could be demonstrated in the non-producer lcl. non-integrated hvp dna had a density of 1.715--1.716 g/cm ...	1978	221325
altered biological and biochemical properties of a phosphonoacetate-resistant mutant of herpesvirus of turkeys.	a phosphonoacetate (pa)-resistant mutant of the herpesvirus of turkeys (hvt) was isolated and characterized. the mutant (hvtpa) replicates in growth medium containing 300 microgram/ml of pa and shows in vitro temperature sensitivity at 41 degrees c (its 37 degrees c/41 degrees c efficiency of replication is about 5). hvtpa replicates poorly in chickens and fails to provide complete protection against mdv challenge. the hvtpa-induced dna polymerase has an apparent inhibition constant for pa 10 ti ...	1978	221331
human herpesvirus 1 as a model of regulation of herpesvirus macromolecular metabolism: a review.		1978	221332
identification and partial purification of two ebv-associated dna polymerases.	virally induced dna polymerases have been demonstrated in cells infected with a variety of herpesviruses. these include herpes simplex virus (weissbach et al., 1973), marek's disease virus (boezi et al., 1974), equine herpesvirus (allen et al., 1977), and cytomegalovirus (huang, 1975a). recently a new iododeoxyuridine (iudr)-induced intracellular dna polymerase in an epstein-barr virus (ebv)-producing hybrid cell line has also been reported (miller et al., 1977). we present evidence that there a ...	1978	221345
herpesvirus production by ultraviolet-irradiated human skin cells: a marker of repair.		1978	221346
oncogenic transformation of non-permissive murine cells by viable equine herpesvirus type 1 (ehv-1) and ehv-1 dna.	primary cultures of balb/c mouse embryo fibroblasts infected with as much as 100 pfu per cell of ehv-1 do not exhibit cytopathology or synthesize detectable amounts of ehv-1 specific rna, dna, or infectious virus. addition of 1--2 microgram of non-fragmented ehv-1 dna as a co-precipitate with calcium phosphate to monolayers of such non-permissive mouse cells resulted in the appearance, after 4--6 weeks, of foci of piled-up, morphologically altered cells. cell lines established from such transfor ...	1978	221355
enhanced efficiency of transfection of hsv dna in hsv-1 dna-transformed hamster cells.	the efficiency of transfection, i.e., the number of plaques per microgram of dna, was compared for herpes simplex virus (hsv) type 1 and type 2, and herpesvirus eidolon (antigenically unrelated to hsv) dnas in hsv dna-transformed cells (eh/a44) and control hamster cells (eht). the efficiency of transfection of hsv-1 and hsv-2 dnas was significantly higher in eh/a44 cells than in eht cells, showing that an early step in hsv infection was involved in the partial resistance of hsv dna-transformed c ...	1978	221357
characterization of the replicative structures of the dna of a herpesvirus (pseudorabies).	the replication of prv dna occurs in two phases, early and late. during the early stages of infection newly synthesized dna is associated with molecules sedimenting with an s-value up to two-fold greater than that of mature viral dna. these molecules represent unit-size linear or circular molecules, as well as small concatemers in the process of replication. initiation of replication occurs at a site situated 20 micron from one of the ends as well as at or near the end of the molecules. at later ...	1978	221363
provisional classification of herpesviruses: herpesvirus study group of the international committee for the nomenclature of viruses.		1978	221375
achievements, priorities and needs in the lucké tumour herpesvirus field.		1978	221378
oncogenesis and herpesviruses iii. part 2: cell-virus interactions, host response to herpesvirus infection and associated tumours, role of co-factors.		1978	221380
pronephric tumour cell lines from herpesvirus-transformed cells.	pronephric tumor cell lines have been established from tumours induced after inoculation of embryos with herpesvirus cultivated in vitro. neoplastic properties of the lines are characterized.	1978	221384
the immunology of primary and recurrent herpesvirus infection: an overview.		1978	221390
persistent, chronic, and latent infections by herpesvirus: a review.		1978	221391
comparison of humoral and cell-mediated responses and virus markers in herpesvirus-associated lymphomas: a review.		1978	221406
prospects for control of herpesvirus-related diseases: a review.		1978	221415
vaccination against diseases associated with herpesvirus infections in animals: a review.	an account is presented of the development and use of herpesvirus vaccines in domestic animals, with particular reference to those viruses causing cytolytic rather than oncogenic infections. the chief infections covered are aujeszky's disease (ad or pseudorabies), infectious bovine rhinotracheitis (ibr) and equine rhinopneumonitis (equine abortion; ehv-1). others mentioned are feline viral rhinotracheitis and malignant catarrhal fever of cattle. both live-modified and inactivated vaccines are wi ...	1978	221416
the interaction between herpesvirus and oncornavirus of guineapigs: in vitro and in vivo studies.	in vitro, cultured guineapig doubly infected with both guineapig herpesvirus (gphlv) and guineapig oncornavirus (gpov) revealed pseudotype virus particles with oncornavirus morphology coated with gphlv antigen as detected by immunoferritin electron microscopy. in vivo, infection of hartley guineapigs with both gphlv and gpov induced hyperplasia in lymph-nodes in a higher percentage of animals than in those that received only one virus type. in addition, experimental gphlv infection of strain 2 g ...	1978	221417
effect of ara-t on the replication of herpes simplex virus, varicella-zoster virus and cytomegalovirus.	the thymidine analogue, 1-beta-arabinofuranosylthymine (ara-t), has previously been found to selectively inhibit herpes simplex virus (hsv) replication. at a relatively non-toxic concentration (50 microgram/ml), ara-t reduced hsv yields by a factor of 10,000-100,000. ara-t was also effective in inhibiting the replication of variecella-zoster virus (vzv) in vitro in human embryo fibroblasts, completely preventing vzv-specific cytopathic effects (cpe). ara-t reduced the cell-free virus and plaque- ...	1978	221418
[isolation and identification of the infectious bovine rhinotracheitis virus in a bovine fetus kidney (ibr/ipv)].	the authors describe the isolation and identification of a virus from bovine fetal kidney cells maintained in culture for 30 to 45 days. the virus was characterized as a herpesvirus of the infectious bovine rhinotracheitis in cell culture by the evidence of cytopathogenic effect in bovine kidney and testis cultures and serologically by a neutralization test using rabbit anti-infectious bovine rhinotracheitis sera.	1978	224840
replication of type i herpes simplex virus in primary cultures of hairy cell leukemic leukocytes.	the ability of leukemic leukocytes to support the replication of herpes simplex virus (hsv) was studied. mononuclear leukocytes (mnl) from the peripheral blood of patients with a variety of lymphoid leukemias were isolated on ficoll-hypaque gradients and infected with hsv at a multiplicity of infection of 5 to 10. no virus growth was detected in cells from patients with chronic lymphocytic leukemia (9), acute lymphocytic leukemia (1), or lymphosarcoma cell leukemia (2), hsv replication did occur ...	1978	202167
herpesvirus ateles dna and its homology with herpesvirus saimiri nucleic acid.	analysis of the structural organization of herpesvirus ateles dna shows that two types of viral dna molecules are encapsidated in virions: (i) m-genomes, which contain 74% light sequences (l-dna, 38% guanine plus cytosine) and 26% highly repetitive heavy sequences (h-dna, 75% guanine plus cytosine), and (ii) defective h-genomes, which consist exclusively of repetitive h-dna. the structure of m-genomes from h. ateles consists of an l-dna region of about 70 x 10(6) daltons inserted between h-dna t ...	1978	202747