Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| prevotella nigrescens and porphyromonas gingivalis are associated with signs of carotid atherosclerosis in subjects with and without periodontitis. | yakob m, söder b, meurman jh, jogestrand t, nowak j, söder p.-ö. prevotella nigrescens and porphyromonas gingivalis are associated with signs of carotid atherosclerosis in subjects with and without periodontitis. j periodont res 2011; doi: 10.1111/j.1600-0765.2011.01398.x. © 2011 john wiley & sons a/s background and objective: oral microorganisms may be involved in the development of cardiovascular diseases, and porphyromonas gingivalis is one of the periodontal microorganisms that has been fou ... | 2011 | 21793826 |
| effect of green tea catechin, a local drug delivery system as an adjunct to scaling and root planing in chronic periodontitis patients: a clinicomicrobiological study. | evaluate the adjunctive use of locally delivered green tea catechin with scaling and root planing, as compared to scaling and root planing alone in the management of chronic periodontitis. | 2011 | 21772720 |
| analysis of the antimicrobial susceptibility of anaerobic bacteria isolated from endodontic infections in brazil during a period of nine years. | the purpose of this study was to analyze the susceptibility of some anaerobic species isolated from a brazilian population at different periods of time by determining a pattern of development of resistance to frequently prescribed antibiotics in endodontics. | 2011 | 21763894 |
| microbiologic changes in subgingival plaque before and during the early period of orthodontic treatment. | abstract objective: to evaluate changes in subgingival microbiota before and during the leveling and alignment orthodontic stage using the polymerase chain reaction (pcr) method. materials and methods: thirty orthodontic patients (17 females and 13 males; aged 16.7 -¦ 6.5-áy) were included in this study. subgingival microbial samples were taken from the disto-buccal gingival crevice of the left upper central incisors, the left lower central incisors, the mesio-buccal gingival crevice of the left ... | 2011 | 21827233 |
| aerosol deposition of hydroxyapatite and 4-hexylresorcinol coatings on titanium alloys for dental implants. | purpose: aerosol deposition is a newly developed technique, and it can deliver the drug from a hydroxyapatite (ha)-coated surface. 4-hexylresorcinol (4-hr) is a well-known antiseptic. the influence of the 4-hr component of ha coatings on titanium surfaces was studied in vitro and in vivo. materials and methods: x-ray diffraction and fourier transform infrared techniques were used for the evaluation of the coating. the cellular response of the coating was evaluated by scanning electron microscopi ... | 2011 | 21821331 |
| live/dead real-time polymerase chain reaction to assess new therapies against dental plaque-related pathologies. | dna-based methodology for the identification and detection of specific bacteria in dental plaque offers advantages over culturing techniques. one drawback of current molecular techniques like real-time quantitative polymerase chain reaction (rt-qpcr) is that they are not able to distinguish between live or dead bacteria. to overcome this problem an assay was assessed to discriminate between viable or dead bacteria using dna intercalating substances, propidium monoazide (pma) and ethidium monoazi ... | 2011 | 21729246 |
| [prevalence of helicobacter pylori detected by real-time pcr in the subgingival plaque of patients with chronic periodontitis]. | helicobacter pylori plays a significant role in gastric disease. the aim of the present pilot study was to evaluate the prevalence of h. pylori detected by real-time polymerase chain reaction (real-time pcr) in the sub-gingival plaque of chronic periodontitis patients and to determine periodontopathogens profile of positive sites at h. pylori. | 2011 | 21688602 |
| clinical, microbiologic, and immunologic factors of orthodontic treatment-induced gingival enlargement. | the aim of this study was to investigate the microbiologic and immunologic factors related to orthodontic treatment-induced gingival enlargement (ge). | 2011 | 21724088 |
| the elicitation step of nickel allergy is promoted in mice by microbe-related substances, including some from oral bacteria. | microbial components activate the host's innate immunity via interactions with molecules including tlrs and nods. we previously reported that in mice (i) escherichia coli lipopolysaccharide (lps; tlr4 agonist) promotes ni-allergy even in t-cell-deficient mice, (ii) e. coli lps reduces the minimum allergy-inducing concentrations of ni at both the sensitization and elicitation steps, and (iii) various microbe-related substances promote sensitization to ni. here, we examined the effects of microbe- ... | 2011 | 21839857 |
| antimicrobial sesquiterpenoids from laurus nobilis l. | activity-guided fractionations of leaf extracts from laurus nobilis l. led to the isolation of a known sesquiterpene lactone, deacetyl laurenobiolide (1). compound 1 showed antimicrobial activity against periopathic pathogens (actinomyces viscosus, porphyromonas gingivalis, prevotella intermedia and actinobacillus actinomycetemcomitans), opportunistic gram-positive bacteria (staphylococcus aureus and streptococcus pyogenes) and fungi (candida albicans, cryptococcus neoformans and aspergillus fum ... | 2011 | 21678158 |
| Simultaneous detection of periodontal pathogens in subgingival plaque and placenta of women with hypertension in pregnancy. | BACKGROUND: There are many studies documenting increased prevalence of periodontal infection in women with preeclampsia. But, very few studies have attempted to establish causal relationship between the two. OBJECTIVE: To find out causal circumstantial evidence by isolating specific periodontal pathogens in oral and placental samples. MATERIALS AND METHODS: Antenatal periodontal screening and subgingival plaque collection was carried out in ten women with hypertension in pregnancy and ten normot ... | 2011 | 21830010 |
| Microbiological analysis of gingivitis in pediatric patients under orthodontic treatment. | The aim of this study was to determine the relationship between gingival inflammation and changes in bacteria of the gingival sulcus in children in orthodontic treatment with brackets. | 2011 | 22185242 |
| Quantitative analysis of microbiota in saliva, supragingival, and subgingival plaque of Chinese adults with chronic periodontitis. | OBJECTIVE: The aim of this study was to determine the profiles of periodontopathogenic bacteria in a Chinese population using quantitative real-time polymerase chain reaction (qRT-PCR). MATERIALS AND METHODS: Twenty-four periodontally healthy Chinese subjects and 60 patients with chronic periodontitis (CP) were enrolled in this cross-sectional study. qRT-PCR was used to quantify Aggregatibacter actinomycetemcomit ... | 2011 | 22169888 |
| Isoflavonoids and Coumarins from Glycyrrhiza uralensis: Antibacterial Activity against Oral Pathogens and Conversion of Isoflavans into Isoflavan-Quinones during Purification. | Phytochemical investigation of a supercritical fluid extract of Glycyrrhiza uralensis has led to the isolation of 20 known isoflavonoids and coumarins, and glycycarpan (7), a new pterocarpan. The presence of two isoflavan-quinones, licoriquinone A (8) and licoriquinone B (9), in a fraction subjected to gel filtration on Sephadex LH-20 is due to suspected metal-catalyzed oxidative degradation of licoricidin (1) and licorisoflavan A (2). The major compounds in the extract, as well as 8, were evalu ... | 2011 | 22074222 |
| Clinical and Microbial Evaluation of the Effects on Gingivitis of a Mouth Rinse Containing an Enteromorpha linza Extract. | Abstract Enteromorpha linza, a green alga, has been recognized as a potential source of natural antimicrobial and antifungal compounds. We previously reported that an E. linza extract strongly inhibited the growth of Prevotella intermedia and Porphyromonas gingivalis. The principal objective of this study was to evaluate the clinical effect of a mouth rinse containing the E. linza extract on gingivitis disease, as measured by the plaque index (PI), gingival index (GI), and bleeding on probing ... | 2011 | 22145775 |
| [Role of several periodontopathogenic microorganisms and tlr4 gene Asp299Gly polymorphism in atherosclerosis pathogenesis]. | Establishment of presence of periodonto-pathogenic microorganisms in atherosclerosis plaque and surrounding tissues, and possible relation of development of atherosclerosis and TLR4 gene Asp299Gly polymorphism in ischemic heart disease patients (IHD). | 2011 | 22145357 |
| effects of mushroom and chicory extracts on the physiology and shape of prevotella intermedia, a periodontopathogenic bacterium. | contrary to the common assumption that food has a negative impact on oral health, research has shown that several foods contain a number of components with antibacterial and antiplaque activity. these natural compounds may be useful for improving daily oral hygiene. in this study we evaluate the mode of antimicrobial action of fractions of mushroom and red chicory extracts on prevotella intermedia, a periodontopathogenic bacterium. the minimal inhibitory concentration corresponded to 0.5x compar ... | 2011 | 21918594 |
| detection of periodontal pathogens in newborns and children with mixed dentition. | we report the age-related prevalence of red complex periodontal pathogens, porphyromonas gingivalis, treponema denticola, and tannerella forsythia, along with four strains of orange complex pathogens. the bacteria present in samples isolated from tongue, cheek, and subgingival sulcus in edentulous newborns and children with mixed dentition were monitored by polymerase chain reaction (pcr). p. gingivalis was not detected in any site of any subject in the two groups tested. however, t. denticola w ... | 2011 | 21928086 |
| synergy in biofilm formation between fusobacterium nucleatum and prevotella species. | the formation of biofilm by anaerobic, gram-negative bacteria in the subgingival crevice plays an important role in the development of chronic periodontitis. the aim of this study was to characterize the role of coaggregation between fusobacterium nucleatum and prevotella species in biofilm formation. coaggregation between f. nucleatum and prevotella species was determined by visual assay. effect of co-culture of the species on biofilm formation was assessed by crystal violet staining. effect of ... | 2011 | 21945879 |
| extracellular deoxyribonuclease production by periodontal bacteria. | palmer lj, chapple ilc, wright hj, roberts a, cooper pr. extracellular deoxyribonuclease production by periodontal bacteria. j periodont res 2011; doi: 10.1111/j.1600-0765.2011.01451.x © 2011 john wiley & sons a/s background and objective: whilst certain bacteria have long been known to secrete extracellular deoxyribonuclease (dnase), the purpose in microbial physiology was unclear. recently, however, this enzyme has been demonstrated to confer enhanced virulence, enabling bacteria to evade the ... | 2011 | 22150619 |
| comparison of the virulence of exopolysaccharide-producing prevotella intermedia to exopolysaccharide non-producing periodontopathic organisms. | evidence in the literature suggests that exopolysaccharides (eps) produced by bacterial cells are essential for the expression of virulence in these organisms. secreted epss form the framework in which microbial biofilms are built. | 2011 | 21864411 |
| effect of a self-etching adhesive containing an antibacterial monomer on clinical periodontal parameters and subgingival microbiologic composition in orthodontic patients. | the aims of this study were to evaluate the effect of a self-etching adhesive system containing an antibacterial monomer on periodontal health and subgingival microbiologic composition in orthodontic patients and to compare it with a conventional adhesive system. | 2011 | 21967952 |
| Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. | Isoliquiritigenin (1) and liquiritigenin (2) are structurally related flavonoids found in a variety of plants. The purpose of this study was to perform a comparative analysis of biological properties of these compounds in regard to their therapeutic potential for oral infections. Compound 1 demonstrated significant antibacterial activity against three major periodontopathogens, Porphyromonas gingivalis, Fusobacterium nucleatum, and Prevotella intermedia. In contrast, 2 exerted less pronounced ef ... | 2011 | 21866899 |
| effects of fruit and vegetable low molecular mass fractions on gene expression in gingival cells challenged with prevotella intermedia and actinomyces naeslundii. | low molecular mass (lmm) fractions obtained from extracts of raspberry, red chicory, and shiitake mushrooms have been shown to be an useful source of specific antibacterial, antiadhesion/coaggregation, and antibiofilm agent(s) that might be used for protection towards caries and gingivitis. in this paper, the effects of such lmm fractions on human gingival kb cells exposed to the periodontal pathogens prevotella intermedia and actinomyces naeslundii were evaluated. expression of cytokeratin 18 ( ... | 2011 | 21941429 |
| Differentially regulated proteins in Prevotella intermedia after oxidative stress analyzed by 2D electrophoresis and mass spectrometry. | Prevotella intermedia is a rod-shaped, Gram-negative anaerobic bacterium found in human indigenous microbiota that plays an important role in opportunistic infections. The successful colonization depends on the ability of anaerobes to respond to oxidative stress (OS) in oxygenated tissues as well as to resist oxidative events from the host immune system until anaerobic conditions are present at the infection site. As knowledge of the mechanisms of protection against OS in Prevotella is limited, ... | 2011 | 22193554 |
| anti-inflammatory effects and the underlying mechanisms of action of daidzein in murine macrophages stimulated with prevotella intermedia lipopolysaccharide. | choi e-y, jin j-y, lee j-y, choi j-i, choi is, kim s-j. anti-inflammatory effects and the underlying mechanisms of action of daidzein in murine macrophages stimulated with prevotella intermedia lipopolysaccharide. j periodont res 2011; doi: 10.1111/j.1600-0765.2011.01422.x. © 2011 john wiley & sons a/s background and objective: host modulatory agents directed at inhibiting specific proinflammatory mediators could be beneficial in terms of attenuating periodontal disease progression and potentia ... | 2011 | 21972936 |
| Associations of periodontal microorganisms with salivary proteins and MMP-8 in gingival crevicular fluid. | OBJECTIVE: We investigated in subjects with and without periodontitis, the levels of certain salivary proteins and matrix metalloproteinase-8 (MMP-8) in gingival crevicular fluid (GCF), in relation to the presence of specific periodontal pathogens. METHODS: Clinical parameters were recorded at baseline, in 1985 and in 2009 from 99 subjects; 56 with and 43 without periodontitis (mean age 59.2 ± SD 2.9). Saliva samples collected in 2009 were analysed for salivary albumin, total protein and immunog ... | 2011 | 22103335 |
| colonisation of the oral cavity by periodontopathic bacteria in complete denture wearers. | gerodontology 2011; doi: 10.1111/j.1741-2358.2011.00506.x colonisation of the oral cavity by periodontopathic bacteria in complete denture wearers objective: the purpose of this study was to investigate colonisation by periodontopathic bacteria and the sites of colonisation in elderly upper and lower complete denture wearers. we also investigated the relationship between level of oral hygiene and colonisation by periodontopathic bacteria. materials and methods: forty edentulous and 37 dentate ... | 2011 | 21929616 |
| dna/protamine complex paste for an injectable dental material. | a dna/protamine complex powder was prepared by reaction between dna and protamine sulfate solution with stirring in order to develop a new injectable biomaterials for dental therapy. the powder of dna/protamine complex became paste by kneading the complex powder and distilled water. complex formation was confirmed by ft-ir measurement. the complex paste had a porous structure and its viscosity was approximately 280.1 pas. the paste could easily pass through a needle of 0.25 mm internal diameter. ... | 2011 | 21922330 |
| molecular detection of human periodontal pathogens in oral swab specimens from dogs in japan. | periodontal diseases are known to be major diseases in humans, and are also common in dogs. the purpose of the present study was to analyze the distribution of periodontitis-related bacterial species using oral swab specimens collected from 26 pet dogs. the distribution of an animal gingival organism porphyromonas gulae, in addition to 10 human periodontitis-related bacterial species, including porphyromonas gingivalis, treponema denticola, tannerella forsythia, capnocytophaga ochracea, capnocyt ... | 2011 | 21916371 |
| salivary biomarkers for predicting the progression of chronic periodontitis. | objective: predicting the progression of periodontitis would allow for targeted supportive periodontal therapy. the purpose of this study was to determine the usefulness of salivary biomarkers for predicting the progression of periodontitis. design: eighty-five chronic periodontitis patients were enrolled in an 18-month longitudinal study. amongst them, 57 experienced progression of periodontitis, indicated at the end of the 18 months by at least one site with >3mm loss of attachment compared wi ... | 2011 | 22030151 |
| the antiplaque efficacy of pomegranate mouthrinse. | to evaluate the effect of a pomegranate-containing mouthrinse on plaque, determine whether it has any adverse effects, and evaluate its antibacterial properties against selected periodontopathogens in vitro. | 2011 | 21206931 |
| effect of smoking on subgingival microflora of patients with periodontitis in japan. | smoking is a risk factor for periodontitis. to clarify the contribution of smoking to periodontitis, it is essential to assess the relationship between smoking and the subgingival microflora. the aim of this study was to gain an insight into the influence of smoking on the microflora of japanese patients with periodontitis. | 2011 | 21208407 |
| identification of periodontal pathogens and severity of periodontitis in patients with and without chronic kidney disease. | in this study of patients with chronic periodontitis (cp), the severity of the disease and the main periodontal pathogens identified in patients with chronic kidney disease (ckd) were compared with those detected in individuals without systemic disease. | 2011 | 21211789 |
| prognosis of periodontitis recurrence after intensive periodontal treatment using examination of serum igg antibody titer against periodontal bacteria. | chronic periodontitis is associated with systemic diseases such as atherosclerosis. in this study, we evaluated the efficacy of serum igg antibody titer to periodontal bacteria for prognosis of periodontitis recurrence during supportive periodontal therapy (spt) phase. the 139 patients during spt phase were selected and divided to two groups as follows: "stable" and "recurrence" group at spt phase for case-control study: "high igg titer" and "normal igg titer" group before transition to spt phas ... | 2011 | 21254239 |
| salivary infectious agents and periodontal disease status. | the potential of salivary microorganisms to diagnose periodontal disease and to guide periodontal treatment is a research topic of current interest. this study aimed to determine whether the salivary counts of periodontopathic microbes correlated with the periodontal pocket counts of the same infectious agents, and whether the salivary counts of the test infectious agents could distinguish among individuals with periodontal health and various types of periodontal disease. | 2011 | 21261620 |
| antimicrobial activity of diterpenes from viguiera arenaria against endodontic bacteria. | six pimarane-type diterpenes isolated from viguiera arenaria baker and two semi-synthetic derivatives were evaluated in vitro against a panel of representative microorganisms responsible for dental root canal infections. the microdilution method was used for the determination of the minimum inhibitory concentration (mic) and minimum bactericidal concentration (mbc) against porphyromonas gingivalis, prevotella nigrescens, prevotella intermedia, prevotella buccae, fusobacterium nucleatum, bacteroi ... | 2011 | 21233793 |
| il6 -174 genotype associated with aggregatibacter actinomycetemcomitans in indians. | genetic factors have recently been associated with presence of aggregatibacter actinomycetemcomitans subgingivally in populations living in industrialized countries. the aim of this study was to analyse associations between interleukin-6 (il6) single nucleotide polymorphisms and presence and levels of a. actinomycetemcomitans and other subgingival microbes in a rural indian population. | 2011 | 20860759 |
| prevotella intermedia stimulates tissue-type plasminogen activator and plasminogen activator inhibitor-2 expression via multiple signaling pathways in human periodontal ligament cells. | prevotella intermedia is an important periodontal pathogen that induces various inflammatory and immune responses. in this study, we investigated the effects of p. intermedia on the plasminogen system in human periodontal ligament (hpdl) cells and explored the signaling pathways involved. using semi-quantitative reverse transcription (rt)-pcr and quantitative real-time rt-qpcr, we demonstrated that p. intermedia challenge increased tissue-type plasminogen activator (tpa) and plasminogen activato ... | 2011 | 21314733 |
| effect of teenage smoking on the prevalence of periodontal bacteria. | the aim of our study was to investigate how teenage smoking affects the prevalence of periodontal bacteria and periodontal health with the hypothesis that smoking increases the prevalence of the bacteria. oral health of 264 adolescents (15- to 16-year-olds) was clinically examined, and their smoking history was recorded. the participants also filled in a structured questionnaire recording their general health and health habits. pooled subgingival plaque samples were taken for polymerase chain re ... | 2011 | 21340603 |
| antibody responses to periodontopathic bacteria in relation to rheumatoid arthritis in japanese adults. | background: periodontopathic bacteria have been implicated as contributory to the etiology of rheumatoid arthritis (ra). anti-cyclic citrullinated peptide (ccp) antibodies and rheumatoid factor (rf) were shown to be associated with ra. this study was undertaken to examine whether serum levels of antibodies to periodontopathic bacteria may affect clinical and laboratory profiles of ra. methods: the study subjects consisted of 80 patients with ra and 38 age-, gender-, smoking status-, and periodon ... | 2011 | 21342003 |
| association between periodontal pathogens and risk of nonfatal myocardial infarction. | the direct effect of periodontal pathogens on atherosclerotic plaque development has been suggested as a potential mechanism for the observed association between periodontal disease and coronary heart disease, but few studies have tested this theory. | 2011 | 21375559 |
| detection of specific periodontal microorganisms from bacteraemia samples after periodontal therapy using molecular-based diagnostics. | the aim of this study was to assess the presence of subgingival pathogens in peripheral blood samples from periodontitis patients before and after scaling and root planing (sc/rp) using nested polymerase chain reaction (nested pcr). | 2011 | 21392048 |
| clustering of subgingival microbial species in adolescents with periodontitis. | it has become increasingly recognized that groups of microorganisms interact within the subgingival plaque of adult subjects with periodontitis. it is much less clear, however, whether the consortia of microorganisms associated with periodontitis are different in early and more advanced cases of periodontitis. to investigate this point further, subgingival plaque was collected from six sites in 87 adolescents with periodontitis and 73 controls and the samples were analyzed for the detection of 1 ... | 2011 | 21410554 |
| azithromycin concentrations in blood and gingival crevicular fluid after systemic administration. | background: azithromycin is a macrolide antibiotic that is active against several periodontal pathogens. macrolides are taken up and concentrated inside gingival fibroblasts, which could influence their pharmacokinetics. this study tested the hypothesis that steady-state levels of azithromycin are higher and more sustained in gingival crevicular fluid (gcf) than in serum. methods: four healthy subjects received an initial dose of 500 mg azithromycin followed by 250 mg doses on each of the next 2 ... | 2011 | 21417585 |
| longitudinal changes in microbiology and clinical periodontal parameters after removal of fixed orthodontic appliances. | the aim of this longitudinal study was to monitor patients' microbiological and clinical parameters from bracket placement up to 3 months post-treatment. twenty-four patients (10 males and 14 females, aged 14.6 ± 1.0 years) were included in this investigation. microbiology (sub- and supragingival), periodontal probing depth (ppd), bleeding on probing (bop), and gingival crevicular fluid (gcf) flow were assessed at baseline (t1), at bracket removal (t2), and 3 months post-treatment (t3). a statis ... | 2011 | 20671070 |
| bovine milk fermented with lactobacillus rhamnosus l8020 decreases the oral carriage of mutans streptococci and the burden of periodontal pathogens. | the aim of this study was to find the oral isolate of lactobacilli, which has the potential to inhibit either periodontal, cariogenic, or fungal pathogens in vitro, and to examine the effects of bovine milk fermented with the isolate on the oral carriage of cariogenic and periodontal pathogens. | 2011 | 25426790 |
| probiotic effects of orally administered lactobacillus reuteri-containing tablets on the subgingival and salivary microbiota in patients with gingivitis. a randomized clinical trial. | to investigate the effects of an orally administered probiotic on the oral microbiota. | 2012 | 22694350 |
| detection of porphyromonas endodontalis, porphyromonas gingivalis and prevotella intermedia in primary endodontic infections in a chinese population. | to assess the prevalence of three black-pigmented bacterial species (porphyromonas endodontalis, porphyromonas gingivalis and prevotella intermedia) using microarray technology in root canals of teeth associated with primary endodontic infections in a chinese population. | 2012 | 22429191 |
| high-fat diet induces periodontitis in mice through lipopolysaccharides (lps) receptor signaling: protective action of estrogens. | a fat-enriched diet favors the development of gram negative bacteria in the intestine which is linked to the occurrence of type 2 diabetes (t2d). interestingly, some pathogenic gram negative bacteria are commonly associated with the development of periodontitis which, like t2d, is characterized by a chronic low-grade inflammation. moreover, estrogens have been shown to regulate glucose homeostasis via an lps receptor dependent immune-modulation. in this study, we evaluated whether diet-induced m ... | 2012 | 23133617 |
| effectiveness of egg yolk immunoglobulin (igy) against periodontal disease-causing fusobacterium nucleatum. | to evaluate the in vitro and in vivo effectiveness of egg yolk immunoglobulin (igy) against periodontal disease-causing fusobacterium nucleatum. | 2012 | 22789022 |
| [impact of periodontal disease on arterial pressure in diabetic mice]. | diabetes-driven cardiovascular diseases represent a high challenge for developed countries. periodontal disease is strictly linked to the aforementioned diseases, due to its gram negative-driven inflammation. thus, we investigated the effects of periodontal disease on arterial pressure during the development of diabetes in mice. to this aim, c57bl/6 female mice were colonized with pathogens of periodontal tissue (porphyromonas gingivalis, prevotella intermedia and fusobacterium nucleatum) for 1m ... | 2012 | 22621847 |
| butyric acid induces apoptosis in both human monocytes and lymphocytes equivalently. | short-chain fatty acids (scfas) are metabolites from anaerobic periodontopathic bacteria that induce apoptosis in immune cells such as lymphocytes, monocytes and macrophages. however, it remains unclear if scfas from pathogens induce apoptosis in monocytes/macrophages similarly with lymphocytes. this study investigated whether scfas-induced apoptosis is equal among the immunoregulatory cells. cell apoptosis of the employed human cells was evaluated after treatment with culture supernatants from ... | 2012 | 22466881 |
| giant frontal mucocele complicated by subdural empyema: treatment of a rare association. | giant frontal mucocele (gfm) is an extremely rare cause of frontal lobe syndrome. subdural empyema (sde) is an uncommon complication of paranasal sinisutis, for which craniotomy and decompressive craniotomy are the most effective surgical procedures. a 54-year-old man was brought unconscious to the emergency room where recurrent generalized seizures occurred. heroine abuse, hcv-related hepatitis, prolonged antibiotic therapy for treatment of purulent rhinorrhea, along with recent personality cha ... | 2012 | 22427297 |
| effects of oil drops containing lactobacillus salivarius wb21 on periodontal health and oral microbiota producing volatile sulfur compounds. | the objective of this paper is to evaluate the effects of oil drops containing lactobacillus salivarius wb21 on periodontal health and oral microbiota producing volatile sulfur compounds (vscs). for this study, 42 subjects were randomly assigned to receive oil samples containing l. salivarius wb21 or a placebo for two weeks. oral assessment and saliva collection were performed on days 1 and 15. bacterial analysis was performed using the real-time polymerase chain reaction and terminal restrictio ... | 2012 | 22368259 |
| inhibition of oral pathogens and collagenase activity by seaweed extracts. | fifty-seven species of common seaweed from the coast of korea were screened for antimicrobial (i.e. inhibition of prevotella intermedia and porphyromonas gingivalis growth) activity. as a source of bioactive compounds, seaweeds can produce many secondary metabolites with a variety of activities. using the agar diffusion method, only 17 species (29.8%) showed inhibitory activity. of these, methanol extracts of enteromorpha linza, sargassum sagamianum, and ulva pertusa showed strong inhibitory eff ... | 2012 | 23033653 |
| does periodontopathic bacterial infection contribute to the etiopathogenesis of the autoimmune disease rheumatoid arthritis? | there is a significant association between rheumatoid arthritis (ra) and periodontal disease (pd). patients with longstanding active ra have been found to have a substantially increased frequency of pd compared with healthy subjects. further, patients with pd have been shown to have a higher prevalence of ra than patients without periodontitis. antibodies to gram-negative, anaerobic periodontal pathogens such as porphyromonas gingivalis, prevotella intermedia, prevotella melaninogenica, and tann ... | 2012 | 22642916 |
| reduction of bacterial volatile sulfur compound production by licoricidin and licorisoflavan a from licorice. | halitosis affects a large proportion of the population and is, in most cases, caused by the production of volatile sulfur compounds (vscs), particularly methyl mercaptan and hydrogen sulfide, by specific bacterial species colonizing the oral cavity. in this study, a supercritical extract of chinese licorice (glycyrrhiza uralensis), and its major isoflavans, licoricidin and licorisoflavan a, were investigated for their effect on growth, vsc production and protease activity of porphyromonas gingiv ... | 2012 | 22368239 |
| peri-implant tissue findings in bone grafted oral cancer patients compared to non bone grafted patients without oral cancer. | the aim of this study was to compare microbiological, histological, and mechanical findings from tissues around osseointergrated dental implants in patients who had undergone tumour resection and subsequent bone grafting with non bone grafted patients without a history of oral cancer and to develop an effective tool for the monitoring of the peri-implant tissues. a third aim was to assess and compare the masticatory function of the two patient groups after reconstruction with dental implants. | 2012 | 24421999 |
| pattern of distribution of prevotella species/phylotypes associated with healthy gingiva and periodontal disease. | the purpose of the present study was to obtain diverse profiles of prevotella species associated with gingival sites in an isolated aboriginal and an urban community by phylogenetic analysis and to establish patterns of association of identified prevotella species in gingival sites. species/phylotypes identified from the phylogenetic analysis of near full-length bacteroidetes 16s rrna gene sequences cloned from subgingival plaque samples obtained from an aboriginal community were compared with t ... | 2012 | 22684253 |
| the importance of genetic variants in tnfα for periodontal disease in a cohort of coronary patients. | the aim of this analysis was to evaluate the importance of genetic variants of tnfα for the severity of periodontal disease and periodontal risk factors with respect to periodontal risk factors in a cohort of coronary patients. | 2012 | 22691114 |
| quantification of cultivable bacteria and endotoxin in post-treatment apical periodontitis before and after chemo-mechanical preparation. | this clinical study was conducted to quantify cultivable bacteria and endotoxin in root canals with post-treatment apical periodontitis by correlating their levels with clinical features and to evaluate the effect of chemo-mechanical preparation (cmp) with 2 % chlorhexidine gel + 17 % edta on bacterial and endotoxin removal/elimination. moreover, target strict gram-negative anaerobic bacteria were investigated by polymerase chain reaction (pcr). fifteen teeth with post-treatment apical periodont ... | 2012 | 22565224 |
| relationship between salivary antioxidant capacity and phases of the menstrual cycle. | reactive oxygen species and free radicals are involved in the pathogenesis of periodontal disease. previous studies have shown that the stage of the menstrual cycle is associated with the levels of gingival inflammation and discomfort. this study examined changes in salivary antioxidant activities, clinical parameters and bacterial levels during the menstrual cycle. | 2012 | 22376058 |
| periodontal disease as a risk factor for rheumatoid arthritis: a systematic review. | the objective of this systematic review is to identify and synthesise the best available evidence to examine whether periodontal disease is a risk factor for rheumatoid arthritis. | 2012 | 27820156 |
| distribution of periodontopathic bacterial species in dogs and their owners. | presently, a large number of individuals consider their companion animals as family members and have close contact with them in daily life. the purpose of the present study was to analyze the distribution of periodontopathic bacterial species in oral specimens taken from dogs and their owners. | 2012 | 22417880 |
| comparative evaluation of the effects of different photoablative laser irradiation protocols on the gingiva of periodontopathic patients. | we aimed at quantifying the presence of periodontopathogens in gingival biopsies from periodontitis patients treated with different photoablative lasers (diode gaas, er:yag, nd:yag, and co(2) lasers) and histologically analyzing their effects on the gingiva. | 2012 | 22401128 |
| the association of aggregatibacter actinomycetemcomitans with preeclampsia in a subset of japanese pregnant women. | to determine whether periodontitis and three prominent members of the periodontal flora are associated with the development of preeclampsia (hypertension plus proteinuria) materials and methods: the samples were composed of 127 systemically healthy women. within 5 days after labour, clinical periodontal parameters and aggregatibacter actinomycetemcomitans, porphyromonas gingivalis and prevotella intermedia in subgingival plaque were evaluated. maternal serum igg antibody specific for each bacter ... | 2012 | 22393563 |
| azithromycin as an adjunctive treatment of generalized severe chronic periodontitis: clinical, microbiologic, and biochemical parameters. | this study examines the efficacy of azithromycin in combination with non-surgical periodontal therapy on clinical and microbiologic parameters and gingival crevicular fluid (gcf) matrix metalloproteinases-8 (mmp-8) levels over 6 months in patients with severe generalized chronic periodontitis (cp). | 2012 | 22324488 |
| contribution of hly homologs to the hemolytic activity of prevotella intermedia. | prevotella intermedia is a periodontal pathogen that requires iron for its growth. although this organism has hemolytic activity, the precise nature of its hemolytic substances and their associated hemolytic actions are yet to be fully determined. in the present study, we identified and characterized several putative hly genes in p. intermedia atcc25611 which appear to encode hemolysins. six hly genes (hlya, b, c, d, e, and hlyi) of p. intermedia were identified by comparing their nucleotide seq ... | 2012 | 22554902 |
| synthesis and antimicrobial activity of geranyloxy- and farnesyloxy-acetophenone derivatives against oral pathogens. | the compounds 2',6'-dihydroxy-4'-geranyloxyacetophenone (1) and 2',6'-dihydroxy-4'-farnesyloxy-acetophenone (2) are oxyprenylated secondary metabolites extracted from plants belonging to the rutaceae family. in this study, 1 and 2 were synthesized and tested for their antimicrobial activity toward major oral pathogens. compounds 1 and 2 were synthesized by selective prenylation of 2,4,6-trihydroxyacetophenone at the 4' position with geranyl and farnesyl bromide, respectively. compound 1 showed s ... | 2012 | 22698715 |
| efficacy of berberine, an antimicrobial plant alkaloid, as an endodontic irrigant against a mixed-culture biofilm in an in vitro tooth model. | berberine, a plant alkaloid isolated from many medicinal plants, has shown antimicrobial activity against selected oral pathogens. the purpose of this investigation was to evaluate the antimicrobial efficacy of berberine solution against selected endodontic pathogens using a multispecies biofilm tooth model. | 2012 | 22794217 |
| in vitro evaluation of mtad and nisin in combination against common pathogens associated with root canal infection. | many pathogenic microorganisms were found in an infected root canal. the object of this study was to evaluate the effect of mtad in combination with nisin on the pathogens associated with root canal infection. | 2012 | 22414835 |
| association of serum anti-periodontal pathogen antibody with ischemic stroke. | periodontitis increases the risk of atherosclerotic cardiovascular disease and ischemic stroke. in this study, we evaluated whether serum antibody levels against individual periodontal pathogens are significantly associated with ischemic stroke subtypes and their risk factors. | 2012 | 23207319 |
| possible translocation of periodontal pathogens into the lymph nodes draining the oral cavity. | numerous publications have reported the presence of periodontopathogenic bacteria in peripheral and central vascular lesions. however, it is unclear how this bacterial translocation occurs. the objective of this study was to investigate whether periodontopathic bacteria are translocated to lymph nodes proximal to the oral cavity. obtaining lymph node samples is not ethically feasible unless they are excised as part of the surgical management of patients with cancer. this study analyzed formalin- ... | 2012 | 23124752 |
| reduction of salivary arginine catabolic activity through periodontal therapy. | salivary enzymes may be used to diagnose periodontal conditions. salivary arginase activity (saa) is related to susceptibility to bacterial infection. therefore, the aim of this controlled interventional study was to determine the saa before and after non-surgical periodontal therapy. | 2012 | 23041992 |
| detection and enumeration of periodontopathogenic bacteria in subgingival biofilm of pregnant women. | the aim of this study was to use the fluorescence in situ hybridization (fish) technique to test the hypothesis of qualitative and quantitative differences of 8 periodontopathogens between pregnant and non-pregnant women. this cross-sectional study included 20 pregnant women in their second trimester of pregnancy and 20 non-pregnant women. probing depth, bleeding on probing, clinical attachment level, and presence of calculus were recorded. subgingival plaque samples were collected and the fish ... | 2012 | 23018230 |
| quantification of periodontopathic bacteria in saliva using the invader assay. | when quantifying periodontopathic bacteria, it is important to use a convenient method that does not produce false negative results. the invader assay is a convenient method because it does not involve gene amplification. the purpose of this study was to evaluate the validity of the invader assay to quantify periodontopathic bacteria. the invader technology was applied in quantifying five periodontopathic bacteria (aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, tannerella forsy ... | 2012 | 22996215 |
| do elderly edentulous patients with a history of periodontitis harbor periodontal pathogens? | the presence of periodontal pathogens in the oral cavity may impact implant survival. therefore, this study aimed to determine the prevalence of campylobacter rectus, porphyromonas gingivalis, aggregatibacter actinomycetemcomitans, prevotella intermedia, tannerella forsythia, treponema denticola, eikenella corrodens, and parvimonas micra in a specific elderly population with a history of periodontitis who have never worn dentures. | 2012 | 22988660 |
| screening for periodontopathogenic bacteria in severe chronic periodontitis in a moroccan population. | bacteria play an important role in destructive periodontitis. the aim of this study was to screen for five highly pathogenic bacteria: aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, prevotella intermedia, tannerella forsythia, and treponema denticola, in moroccan patients presenting with severe chronic periodontitis and to compare results with those of patients presenting with severe aggressive periodontitis. | 2012 | 23141872 |
| antibiotic susceptibility profiles of oral pathogens. | periodontitis is a bacterial disease that can be treated with systemic antibiotics. the aim of this study was to establish the antibiotic susceptibility profiles of five periodontal pathogens to six commonly used antibiotics in periodontics. a total of 247 periodontal bacterial isolates were tested for susceptibility to the six antibiotics using the etest method. mic(50) and mic(90) values (minimum inhibitory concentrations for 50% and 90% of the organisms, respectively) were calculated. both eu ... | 2012 | 22890195 |
| prediagnostic plasma antibody levels to periodontopathic bacteria and risk of coronary heart disease. | many epidemiological studies have indicated that periodontitis is an important risk factor for coronary heart disease (chd). we examined whether plasma antibody levels to 3 major periodontal pathogens, aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, and prevotella intermedia predicted the risk of chd events. a nested case-control research design (case: n = 191, control: n = 382), by matching gender, age, study area, date of blood collection, and time since last meal at blood col ... | 2012 | 22878796 |
| antimicrobial activity of nanoparticulate metal oxides against peri-implantitis pathogens. | dental plaque accumulation may result in peri-implantitis, an inflammatory process causing loss of supporting bone that may lead to dental implant failure. the antimicrobial activities of six metal and metal oxide nanoparticles and two of their composites against bacterial pathogens associated with peri-implantitis were examined under anaerobic conditions. the activities of nanoparticles of silver (ag), cuprous oxide (cu(2)o), cupric oxide (cuo), zinc oxide (zno), titanium dioxide (tio(2)), tung ... | 2012 | 22727529 |
| [amalgam, composite and compomer: microbiological study]. | restorative materials have different consequences on the periodontium. the surface of these materials may influence gingival health and cause in some instances gingival inflammation. the purpose of this study was to investigate and compare, in a healthy periodontium, intracrevicular plaque bacteria (aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, prevotella intermedia, tannerella forsythensis and treponema denticola), at day 0 and at 6 months, around subgingivally located amalga ... | 2012 | 22715643 |
| subgingival microbiota from cebus apella (capuchin monkey) with different periodontal conditions. | this present study evaluated the subgingival microbiota of the cebus apella with different periodontal conditions kept by the tufted capuchin monkey procreation center (são paulo state university - unesp) or free-ranging monkeys. for this purpose, clinical specimens of subgingival biofilm were collected from 52 monkeys, of both genders, 40 kept in captivity and 12 free-ranging monkeys. the primates were submitted to periodontal evaluation and biofilm samples were transferred to vmga iii transpor ... | 2012 | 22710412 |
| a common periodontal pathogen has an adverse association with both acute and stable coronary artery disease. | the aim of this study was to investigate the association between angiographically verified coronary artery disease (cad) and salivary levels of four major periodontal pathogens. | 2012 | 22704805 |
| fcγriib-nt645+25a/g gene polymorphism and periodontitis in japanese women with preeclampsia. | fcγriib contains a unique immunoreceptor tyrosine-based inhibition motif (itim) and functions as a negative feedback regulator of leucocyte activation and antibody production. we have previously reported fcγriib-nt645+25a/g gene polymorphism to be associated with prevalence and severity of periodontitis, fcγriib expression level on peripheral b lymphocytes and the serum igg level against periodontopathic bacteria. previous studies have reported maternal periodontal disease to be associated with ... | 2012 | 22594540 |
| effect of azithromycin, as an adjunct to nonsurgical periodontal treatment, on microbiological parameters and gingival crevicular fluid biomarkers in generalized aggressive periodontitis. | emingil g, han b, özdemir g, tervahartiala t, vural c, atilla g, baylas h, sorsa t. the effect of azithromycin, as an adjunct to nonsurgical periodontal treatment, on microbiological parameters and gingival crevicular fluid biomarkers in generalized aggressive periodontitis. j periodont res 2012; 47: 729-739. © 2012 john wiley & sons a/s background and objective: to study the effectiveness of azithromycin in combination with nonsurgical periodontal therapy on clinical and microbiological parame ... | 2012 | 22571226 |
| microbial profile of patients with periodontitis compared with healthy subjects. | objective: to define and compare the microbiologic profile of subgingival plaque in german patients with periodontitis (including aggressive and advanced chronic periodontitis) and healthy subjects and to determine significant association between isolates and clinical status. aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, and tannerella forsythia are major periodontal pathogens, though it is recognized that other species may also contribute to the pathogenesis of periodontal di ... | 2012 | 22257880 |
| full-mouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: a randomized, placebo-controlled trial. | aim: the present investigation aimed to analyse clinical and microbiological effects of systemic administration of metronidazole and amoxicillin combined with the one-stage-full-mouth-disinfection protocol (osfmd) in generalized aggressive periodontitis patients (g-agp). materials and methods: thirty-nine systemically healthy patients with g-agp were consecutively included. the test group (n = 19) received amoxicillin-metronidazole combination (500 mg of each, three times a day for 7 days) and t ... | 2012 | 22220822 |
| evaluation of periodontal pathogens in amniotic fluid and the role of periodontal disease in pre-term birth and low birth weight. | pre-term birth and/or low birth weight (ptlbw) is a serious problem in developing countries. the absence of known risk factors in ≈ 50% of ptlbw cases has resulted in a continued search for other causes. the aim of this study was to examine the effect of periodontitis on pregnancy outcomes. | 2012 | 23638858 |
| identification of organic acids in cichorium intybus inhibiting virulence-related properties of oral pathogenic bacteria. | the low molecular mass (lmm) extract of cichorium intybus var. silvestre (red chicory) has been shown to inhibit virulence-linked properties of oral pathogens including streptococcus mutans, actinomyces naeslundii and prevotella intermedia. in the present study hplc-dad-esi/ms(2) was used to investigate the compounds contained in this extract for their anti-virulence activity. the extract contained a number of components, including oxalic, succinic, shikimic and quinic acids, which interfere wit ... | 2012 | 23411301 |
| periodontal conditions during the pregnancy associated with periodontal pathogens. | to describe the bacterial associations in the periodontal pockets of pregnant women and to correlate the presence of prevotella intermedia, tannerella forsythia (t. forsythia), treponema denticola (t. denticola), aggregatibacter actinomycetemcomitans, and porphyromona gingivalis (p. gingivalis) with periodontal parameters of severity. | 2012 | 23335585 |
| [removal of oral prevotella intermedia endotoxin by octyl phenyl polyoxyethylene ether extraction method]. | to investigate an effective purification method for removing endotoxin from prevotella intermedia. | 2012 | 23328097 |
| biofilms of black tooth stains: pcr analysis reveals presence of streptococcus mutans. | this study investigated the presence of the black-pigmented bacteria prevotella nigrescens and prevotella intermedia, the non-black-pigmented bacteria actinomyces spp and particularly the cariogenic pathogen streptococcus mutans in the dental biofilms of patients with or without black extrinsic tooth stains, using the multiplex polymerase chain reaction (pcr) technique. analysis of the dental biofilms of patients with (n=26) or without (n=26) black tooth stains was performed using duplex pcr for ... | 2012 | 23306233 |
| [expression of cytokines in dentogingival sulcus in patients after dental implantation and during development of peri-implantitis]. | determination of cytokine content in various areas of dentition in patients with peri-implantitis associated with parodontopathogenic bacteria species of i and ii order. | 2012 | 23297645 |
| treponema denticola associates with increased levels of mmp-8 and mmp-9 in gingival crevicular fluid. | objectives: the aim was to assess the association between the presence of site-specific subgingival micro-organisms and the levels of matrix metalloproteinases-8 and matrix metalloproteinases-9 (mmp-8 and mmp-9) in gingival crevicular fluid (gcf). materials and methods: the patient group consisted of 56 subjects with periodontitis and the control group of 43 subjects without periodontitis. gcf samples from four test sites for each subject were collected. polymerase chain reaction was used to det ... | 2012 | 23294114 |
| validation of a quantitative real-time pcr assay and comparison with fluorescence microscopy and selective agar plate counting for species-specific quantification of an in vitro subgingival biofilm model. | subgingival biofilms are the prime etiological factor of periodontal disease. owing to their complex polymicrobial nature, quantification of individual bacterial species within the biofilm for research and diagnostic purposes can be methodologically challenging. the aims of this study were to establish a quantitative real-time pcr (qpcr) assay to quantify the bacteria used in our 10-species in vitro 'subgingival' biofilm model and to compare the quantitative outcome with fluorescence microscopy ... | 2012 | 23278531 |
| identification and functional analysis of the gene cluster for fructan utilization in prevotella intermedia. | fructanase enzymes hydrolyze the β-2,6 and β-2,1 linkages of levan and inulin fructans, respectively. we analyzed the influence of fructan on the growth of prevotella intermedia. the growth of p. intermedia was enhanced by addition of inulin, implying that p. intermedia could also use inulin. based on this finding, we identified and analyzed the genes encoding a putative fructanase (frua), sugar transporter (frub), and fructokinase (fruk) in the genome of strain atcc25611. transcript analysis by ... | 2012 | 23266804 |
| optimization of quantitative polymerase chain reactions for detection and quantification of eight periodontal bacterial pathogens. | the aim of this study was to optimize quantitative (real-time) polymerase chain reaction (qpcr) assays for 8 major periodontal pathogens, i.e. aggregatibacter actinomycetemcomitans, fusobacterium nucleatum, parvimonas micros, porphyromonas gingivalis, prevotella intermedia, tanerella forsythia and treponema denticola, and of the caries pathogen streptococcus mutans. | 2012 | 23199017 |
| cleavage of igg1 in gingival crevicular fluid is associated with the presence of porphyromonas gingivalis. | immunoglobulin (ig) g1 plays an important role in the adaptive immune response. kgp, a lysine-specific cysteine protease from porphyromonas gingivalis, specifically hydrolyses igg1 heavy chains. the purpose of this study was to examine whether cleavage of igg1 occurs in gingival crevicular fluid (gcf) in vivo, and whether there is any association with the presence of porphyromonas gingivalis and other periodontopathogens. | 2012 | 23116446 |