Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| chromosome 14 translocation in african and north american burkitt's lymphoma;. | two established north american burkitt lymphoma cell lines were studied by chromosomal banding techniques. the su-amb-1 line previously shown to be negative for the epstein-barr virus (ebv) was found to have, among other changes, a translocation from the long arm (q) of chromosome 8 onto 14q. the su-amb-2 line, which contains the ebv genome, also displayed the same 8/14 translocation. these results were compared with data from three ebv-positive tumor cell lines derived from patients with africa ... | 1977 | 844916 |
| a new class of infectious agents detectable by the production of chorioallantoic membrane lesions by human lymphoblastoid cell lines and their culture supernatants. | intravenous injection of cells and their tissue culture supernatants (cs) from human lymphoblastoid cell lines (lcl) induced the formation of lesions on the chorioallantoic membrane (cam) of the chicken embryo. injection of cells and cs from non-lcl and normal human lymphocytes induced few or no lesions. irradiated chick embryos were more sensitive to lesion formation than were nonirradiated embryos. the log10 cam lesions induced in irradiated (500 rads) embryos were a linear function of the log ... | 1977 | 845990 |
| burkitt's lymphoma in australia. | an australian case of burkitt's lymphoma is reported. the clinical features of large ovarian masses and subsequent bone marrow invasion, as well as the results of investigations related to the epstein-barr virus, were more consistent with the american than the african type of burkitt's lymphoma. after a good initial response to cyclophosphamide and vincristine, the tumour rapidly became resistant to these and other therapeutic measures and the patient died 10 months after diagnosis. | 1977 | 859483 |
| sequential evaluation of cutaneous delayed hypersensitivity responses to recall and to lymphoid cell line antigens in burkitt's lymphoma. | delayed cutaneous hypersensitivity reactions to standard recall antigens (candidin, mumps and ppd), to crude membrane extracts of a cell line derived from burkitt's lymphoma (raji) and to cell line derived from normal lymphocytes (f265) were sequentially evaluated in 44 patients with burkitt's lymphoma. sixteen patients (36%) manifested delayed hypersensitivity responses to the standard antigens and seven (16%) to the raji membrane extract at presentation. following successful chemotherapy, ther ... | 1977 | 903183 |
| [serologic survey for the determination of antibodies against various virus infections, mycoplasma, beta hemolytic a streptococcus and toxoplasma gondii, performed on children of a state-of-mexico municipality]. | a seroepidemiologic inquest was carried out in 667 children from the county of huixquilucan, mexico, looking for serum antibodies against infections caused by the following microorganisms: epstein-barr virus; cytomegalovirus; syncytial respiratory; para-influenza 1, 2 and 3; measles; rubella; mumps; mycoplasma pneumoniae, beta hemolytic a streptococcus and toxoplasma gondii. the findings are reported. considerations are made on the incidence of these diseases in different age groups and a compar ... | 1977 | 911440 |
| [carcinoma of the nasopharynx in the young subjects. clinical, pathological and ultrastructural study of 50 cases in eastern algeria (author's transl)]. | africa, and in particular north africa, is a site of high prevalence of carcinoma of the nasopharynx in the young subject. there is a marked male predominance and a clear peak of incidence between 15 and 25 years. the presenting feature is usually rapidly growing cervical lymphadenopathy. the diagnosis is based upon histological examination of these nodes. it is a squamous carcinoma, usually highly undifferentiated and difficult to identify. however, for the experienced observer, the special app ... | 1977 | 600721 |
| biologic and antigenic characteristics of epstein-barr virus-related herpesviruses of chimpanzees and baboons. | leukocyte-transforming agents were isolated in baboon leukocytes inoculated with oral excretions from immunosuppressed chimpanzees. the transformed lymphoblasts had b cell surface markers and harbored herpes-type virus particles; 5-10% of the cells contained cytoplasmic antigens reactive with epstein-barr virus (ebv)-antibody-positive chimpanzee, human and baboon sera. these sera also neutralized the transforming activity of the chimpanzee virus. long-term lymphoid cell lines were established fr ... | 1977 | 409690 |
| membrane antigen expression in epstein-barr virus-infected raji cells in the presence of phosphonoacetic acid. | the expression of the epstein-barr virus (ebv)-induced membrane antigen (ma) in raji cells experimentally infected with ebv concentrates was inhibited by phosphonoacetic acid (paa) as determined by membrane immunofluorescence and inhibition of antibody-dependent lymphocyte cytotoxicity. paa was only effective if present during the first 24 hr following virus adsorption, indicating that the synthesis of ma was primarily a late viral gene function requiring viral dna synthesis. | 1977 | 18625491 |
| nasopharyngeal and adjacent neoplasms: a clinico-pathologic and immunologic study. | thirteen cases of nasopharyngeal carcinoma (npc) and 16 cases of non-npc tumors in the nasopharynx or in adjacent locations were investigated clinically, immunologically, and pathologically. all tumors were classified according to the tnm classification, and the stage and course of the disease was correlated with the histological tumor type, the t- and b-cell distribution in tumor tissue and in the peripheral blood, as well as with antibody titers against epstein-barr virus (ebv). the results sh ... | 1978 | 305242 |
| establishment of a t-cell line from human lymphosarcoma. | a leukemic t-cell line, designated as tall-1, has been established in continuous culture from the bone marrow of a patient with a leukemic phase of t-cell lymphosarcoma. tall-1 cells have t-cell properties and lack epstein-barr virus or its genome. the cells of tall-1 line are considered to have originated from the donor's leukemic cells on the basis of their cytogenetic, morphological, and surface features. | 1978 | 305872 |
| rabbit antiserum against daudi-cell membrane fractions detects cell surface antigens present on subpopulations of human lymphocytes. | an antiserum was produced by immunization of rabbits with membrane preparations of a human lymphoblastoid b cell line, daudi. after absorption with a human endometrial carcinoma cell line, this antiserum appeared to be specific for antigen(s) present on adult and fetal thymocytes as well as on tonsillar lymphocytes but absent, or present in very small amounts, on normal or phytohemagglutinin- (pha) stimulated peripheral blood lymphocytes (pbl). when t and b cell-enriched fractions from tonsillar ... | 1978 | 307019 |
| human t lymphocyte cell line producing colony-stimulating activity. | we derived a permanent human t lymphocyte cell line that elaborates a potent colony-stimulating activity (csa). the line was established with spleen cells from a patient with a t lymphocyte variant of hairy-cell leukemia. these cells form rosettes with sheep erythrocytes, show a proliferative response to phytohemagglutinin, and are lysed by antithymocyte globulin. they do not synthesize immunoglobulin, nor do they contain epstein-barr virus. csa is regularly detected in the supernatant medium af ... | 1978 | 308824 |
| a histopathological study of lymphoid tissue reaction to metastatic nasopharyngeal carcinoma in nude mice. | in attempts to heterotransplant human npc into nude mice, using seven cultured cell lines, we have succeeded in growing a carcinoma simplex, composed of epstein-barr virus-determined nuclear antigen-positive and epstein-barr virus genome-positive cancer cells, at the injected site with two of the cell lines. these originated from a spindle-cell carcinoma (chinese npc-204) and from a combined-cell carcinoma (chinese npc-501), respectively. during the first few passages, wandering macrophages were ... | 1978 | 310417 |
| studies in porphyria. vii. induction of uroporphyrinogen-i synthase and expression of the gene defect of acute intermittent porphyria in mitogen-stimulated human lymphocytes. | a 50% reduction in the activity of uroporphyrinogen-i (uro) synthase in liver, erythrocytes, and cultured skin fibroblasts characterizes all patients with clinically active acute intermittent porphyria (aip). the same enzyme defect has also been demonstrated in the erythrocytes and skin fibroblasts of completely latent gene carriers of this disorder and presumably exists in the liver as well. in this study, we examined whether or not the formation of uro-synthase is impaired in aip cells using l ... | 1978 | 621286 |
| fatal aplastic anaemia complicating infectious mononucleosis. | a 7-year-old boy developed fatal aplastic anaemia, 2 weeks after the first signs of infectious mononucleosis. although some drugs were administered, infection with the epstein-barr virus, leading to infectious mononucleosis, is assumed to be the cause of this aplastic anaemia. some mechanisms possibly leading to the aplasia are discussed. | 1978 | 625631 |
| infectious mononucleosis associated with rhabdomyolysis and renal failure. | acute rhabdomyolysis and renal failure occurred in a 16-year-old boy with infectious mononucleosis; recovery was complete. renal failure is a rare complication of infectious mononucleosis. rhabdomyolysis has been reported only once in association with the epstein-barr virus, but has frequently been associated with influenza virus infections. prospective studies measuring creatine phosphokinase enzymes should establish the frequency of rhabdomyolysis in viral infections. | 1978 | 628861 |
| anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. identification of the anti-viral activity as interferon and characterization of the human effector lymphocyte subpopulation. | a viral inhibitor(s) is released in the supernate of mixed cultures containing human or mouse lymphocytes and cells from certain lines. the inhibitor is active against a variety of unrelated viruses and is a protein that is not toxic for cells. it does not inactivate viruses directly, but inhibits viral replication through an intracellular mechanism that involves synthesis by the cells of both rna and protein. these characteristics identify the inhibitor as an interferon. the anti-viral activity ... | 1978 | 650155 |
| [bcg vaccination, cancer and infectious mononucleosis. a retrospective study of hospitalized patients]. | a retrospective study (1966--1976) of patients hospitalized for cancer was carried out to determine a possible relationship with bcg vaccination, with a control group matched for age and sex and a similar study concerning infectious mononucleosis. among 105 patients with cancer, 54 (51.42%) had been previously vaccinated with bcg, 56 (53.33%) in the control group, and 22 (33.84%) among the 65 patients with infectious mononucleosis (p less than 0.05, x2). the mean age on admission for cancer or i ... | 1978 | 711498 |
| fever of undetermined origin: role of cytomegalovirus and epstein-barr virus. | roles of various infections, neoplasms and granulomatous diseases in fever of unknown origin were studied in 22 patients. bacterial infections were responsible in seven (32 percent), herpes viruses in five (23 percent), neoplasms in four (18 percent) and granulomata in two (9 percent) cases. patients with herpes infections had initially no clinical or routine laboratory clues to viral involvement, and were given an intensive workup for 5 to 15 days. the diagnosis was made on the basis of cytomeg ... | 1978 | 716387 |
| transcription and circular dichroism of chromatin in lymphoblastoid cell lines during proliferation and quiescence. | rna polymerase activity of nuclei and positive circular dichroism ellipticity in the 250--300 nm region of chromatin were studied in three lymphoblastoid cell lines: hri, an epstein-barr virus (ebv) positive virus-producing line; raji, and ebv positive virus-producing line; raji, an ebv positive non-producer line; and su-amb-1, and ebv negative line. raji consistently exhibited the highest and su-amb-1 the lowest polymerase activity and ellipticity. all lines showed higher rna polymerase activit ... | 1978 | 718933 |
| spontaneous resolution of severe aplastic anemia associated with viral hepatitis a in a 6-year-old child. | recovery from acquired aplastic anemia associated with hepatitis is rare. this case of a 6-year-old boy with severe aplastic anemia is the first reported association of this disease with a hepatitis a infection. antibody to hepatitis a (anti-ha) was not detected on admission, but was detected three weeks later. infection with hepatitis b virus, cytomegalovirus (cmv), and epstein-barr virus (ebv) were excluded. the peak titer of anti-ha was higher than would be expected for passive transfer of an ... | 1978 | 752262 |
| epstein-barr virus (ebv) receptors, complement receptors, and ebv infectibility of different lymphocyte fractions of human peripheral blood. i. complement receptor distribution and complement binding by separated lymphocyte subpopulations. | 1978 | 340053 | |
| [epidemiology of burkitt's lymphoma in tropical areas - its relationship with malaria (author's transl)]. | epidemiology of tropical burkitt's lymphoma shows the concomitant existence of the three following characteristics in endemic areas: - fairly dense rural population with a low standard of living; - early occurrence of primary infection by the epstein-barr virus (whose genome is always present in all tumour cells); - stable malaria. the social and economic level of these areas accounts for the specific features of the viral infection. climatic factors determine permanent of prolonged transmission ... | 1978 | 345230 |
| immunohistochemistry of local immunoglobulin production in nasopharyngeal carcinoma. | immunohistochemical investigations by the immunoperoxidase method have been carried out on sections of biopsy specimens obtained from the primary tumour sites of patients with nasopharyngeal carcinoma (npc). it was found that, in many of the sections thus examined, there was an accumulation of plasma cells, particularly of the iga type, in the connective tissues surrounding nests of npc cells. similar accumulation of plasma cells in the subepithelial connective tissues was likewise observed in a ... | 1978 | 348224 |
| the virology and immunology of burkitt's lymphoma in africa and the need for corresponding studies in the high endemic regions of papua new guinea. | 1978 | 220813 | |
| sister chromatid exchange in patients with viral disease. | sister chromatid exchange (sce) frequencies were studied in differentially stained chromosomes from lymphocytes of 17 patients with viral disease. the mean sce score for the patients was 8.7 +/- 2.9 standard deviations. sce scores were significantly elevated in the patients compared with the controls (p less than 0.01); however, variability in sce means was observed in the patients. sce elevations were also present in long term cultured epstein barr virus positive human b lymphocytes. | 1978 | 233771 |
| expression of altered ribonucleotide reductase activity associated with the replication of the epstein-barr virus. | 1978 | 210572 | |
| current assessment of "case clustering" of lymphomas and leukemias. | 1978 | 210923 | |
| host cell reactivation of epstein-barr virus in normal and repair-defective leukocytes. | 1978 | 210932 | |
| a greatly simplified method of establishing b-lymphoblastoid cell lines. | ten lymphoblastoid cell lines were established by epstein-barr virus-induced transformation directly from 0.04 to 0.15 ml of peripheral whole blood of one patient with xeroderma pigmentosum and four normal healthy adults. all these lines expressed b-lymphocyte characteristics. the advantages of this method are: (a) only a few drops of blood are required for establishing a permanent line; (b) damage and loss of cells in separation procedures are minimal; and (c) the method is simple, reliable, an ... | 1978 | 210942 |
| clones of human lymphoblastoid cell lines producing antibody to tetanus toxoid. | 1978 | 211002 | |
| establishment of specific antibody producing human lines by antigen preselection and ebv-transformation. | 1978 | 211003 | |
| epstein-barr (eb) virus genome-containing, eb nuclear antigen-negative b-lymphocyte populations in blood in acute infectious mononucleosis. | experiments have been performed to identify the type and size of cell infected by eb virus in the blood of acute infectious mononucleosis (im) patients, and to investigate the nature of the infection. virus-infected cells, recognized by their ability to give rise to lymphoblastoid cell lines when co-cultivated with foetal lymphocytes, were shown to be restricted to the b-lymphocyte population. samples of this population from each of eight im patients were found to be negative for eb nuclear anti ... | 1978 | 204732 |
| virological aspects of head and neck cancer. | 1978 | 201814 | |
| epstein-barr-virus immunity and tissue distribution in a fatal case of infectious mononucleosis. | 1978 | 201839 | |
| [early granuloma formation, a rise in eb virus antibody titer with an interesting ultrastructural observation and reticulum cell sarcoma-like pattern--an autopsy case]. | 1978 | 215801 | |
| epstein-barr virus (ebv) antibody in patients treated by radical radiotherapy for head and neck cancer. | antibody against epstein barr viral capsid (ebv-vca) was measured in 65 patients with primary head and neck cancer referred for radical radiotherapy. sixty-three percent had locally advanced cancer and 37% had early disease. forty-eight percent had detectable antibody in their sera. thirty-three percent had elevated titers (above 1:20 dilution). only 19% of cases with early cancer had increased titers. almost 50% of those with locally advanced cancer or recurrence following treatment had titers ... | 1978 | 215844 |
| [recent data on the pathogenic role of the epstein-barr virus]. | 1978 | 215968 | |
| [epstein-barr virus and infectious mononucleosis. a clinical study of epstein-barr antibodies (author's transl)]. | thirty-seven patients--aged 2 to 58--with clinical and hematological signs of infectious mononucleosis were studied. thirty patients gave serologic evidence of epstein-barr virus infections; antibodies to viral capsid antigen (vca) appeared very early (only two seroconversions and 4 cases of increased titer were detected); antibodies to early antigen (ea) occured in 25 patients, but only 9 had high titers; antibodies to nuclear antigen (ebna) appeared late in the course of the disease. vca-speci ... | 1978 | 215969 |
| biology of the human malignant lymphomas. | 1978 | 216061 | |
| herpesviruses, venereal disease, and cancer. | 1978 | 216293 | |
| discordance of epstein-barr virus (ebv) specific humoral and cellular immunity in patients with malignant lymphomas: elevated antibody titres and lowered in vitro lymphocyte reactivity. | 1978 | 217561 | |
| electron microscopic studies of tumor viruses. ii. entry and uncoating of epstein-barr virus. | entry of epstein-barr virus into human lymphoblastoid cells (daudi cells) was studied by electron microscopy. at the site of viral attachment, two distinct interactions conducive to penetration of the virus occurred between the viral envelope and cell membrane, namely, (i) simultaneous dissolution of both the envelope and cell membrane, presumably resulting in passage of viral capsids into the cytoplasm and (ii) dissolution confined to the cell membrane with resulting penetration of enveloped vi ... | 1978 | 214669 |
| epstein-barr virus early antigen titer by immunofluorescence in microplates. a new semi-automated method based on microtiter system. | for the titration of antibodies directed against epstein-barr virus early antigen (ebv-ea) we describe a method in microplates with the microtiter system (cooke engineering co., alexandria, va). using this technique, which allows rapid epidemiological investigations, we have titered anti-ebv-ea antibodies in different groups of patients and controls, and particularly in group which had recent contact with infectious mononucleosis. in this group the percentage of individuals having antibodies dir ... | 1978 | 214682 |
| complete heart block in epstein-barr myocarditis. | 1978 | 214746 | |
| antigenic content of an in vitro cellular immunity reactive cell surface extract of raji cells. | antigenic content of a raji cell surface extract (ts) was studied by sequential abosrption of rabbit antiserum to this extract with different cells. anti-ts was first allowed to react exhaustively with human blood cells followed by hela cells and human diploid fibroblasts. the residual reactivity was studied by stepwise absorption with an ebv-negative b lymphoblastoid cell line, bjab, and then with b1--19, a clone derived from ebv transformed bjab cells. these processes delineated three kinds of ... | 1978 | 215106 |
| a study of epstein barr virus receptor activity in cell free extracts of human lymphoblastoid cells. | epstein barr virus (ebv) receptor activity in cell free extracts is operationally defined as one which causes a reduction in the effective concentration of the early antigen inducing particles of an ebv preparation when the latter is preincubated with the extract before infection. such activity was detected in the surface extract of raji cells and to a lesser extent in that of bjab cells, both of which are b lymphoblastoid cells that are susceptible to infection with ebv. receptor activity was n ... | 1978 | 215107 |
| histological types of nasopharyngeal carcinoma in an intermediate risk area. | between april and december 1974, 485 cases of npc were seen at the salah azaïz institute in tunis. a histological study was carried out according to a classification that comprises four types of tumour:well-differentiated squamous-cell carcinoma, poorly-differentiated squamous-cell carcinoma, 'nasopharyngeal' type carcinoma and an anaplastic type. some correlation between these histological types and clinical, epidemiological, virological and prognostic features was found. | 1978 | 215511 |
| clinical aspects and natural history of nasopharyngeal carcinoma in western europe. | 1978 | 215512 | |
| descriptive and analytical epidemiology of nasopharyngeal cancer. | information concerning the descriptive and analytical epidemiology of npc that has been reported mainly since the first international symposium on the subject in singapore in 1964 are reviewed. npc is rare in most countries in the world, with an age-adjusted incidence rate of less than 1 per 100,000, and the incidence rate is twice as high in males as in females. chinese of southern origin have a uniquely high risk, the incidence rates per 100,000 being 10--20 in males and 5--10 in females. the ... | 1978 | 215514 |
| histopathological types of nasopharyngeal carcinoma in a low-risk area: japan. | npc in japan was studied histopathologically by examining 816 npcs from among 3 338 biopsies from patients with tumours of the nasopharynx and other parts of the upper respiratory system. in addition, a comparative study on npc among taiwanese and an immunoserological study were carried out. when comparing histological types of malignant tumours of the upper respiratory tract, poorly-differentiated squamous-cell carcinoma predominated only in those of the nasopharynx. malignant nasopharyngeal tu ... | 1978 | 215515 |
| histological typing of nasopharyngeal carcinoma. | there is little agreement about correlations between histological type and the epidemiological and biological characteristics of npc. this is largely due to variations in terminology and diagnostic criteria. the use of the terminology and definitions proposed by who would facilitate and improve international comparisons. | 1978 | 215516 |
| epstein-barr virus--discovery, properties and relationship to nasopharyngeal carcinoma. | 1978 | 215517 | |
| morphological transformation of nasopharyngeal epithelial cells in vitro by epstein-barr virus from b95-8 cells. | tissue fragments of fresh biopsy specimens from the non-neoplastic np mucosa of 20 subjects, from the tumours of 10 npc patients, from the mucosa of freshly removed tonsils from nine subjects and from the primary lesions of seven patients with malignancies of the upper respiratory or alimentary tract other than npc were infected with ebv derived from b95-8 cells. a significantly higher frequency of growth stimulation and a greater mean growth ratio between infected and uninfected fragments from ... | 1978 | 215518 |
| epstein-barr virus-regulation studies on somatic-cell hybrids derived from the fusion of burkitt's lymphoma and nasopharyngeal carcinoma cells with human or mouse partners. | 1978 | 215519 | |
| epstein-barr virus-epithelial cell interaction and its implication in the etiology of nasopharyngeal carcinoma. | the etiological role of ebv in npc is still a matter for debate. a major question is how the viral dna becomes associated with the carcinoma cell, since only b lymphocytes are at present known to have receptors to ebv. the following hypotheses are proposed: (1) the epithelial cells of the nasopharynx have ebv receptors in vivo; transformation of the epithelial cell thus results from a direct interaction between ebv and this cell type. the epithelial cells of the nasopharynx are not permissive fo ... | 1978 | 215520 |
| early and late components of epstein-barr virus-associated membrane antigen in superinfected daudi cells and their reactivity with sera from nasopharyngeal carcinoma patients. | investigations were carried out on newly synthesized ma, vca and ea in daudi cells superinfected with the p3hr-1 strain of ebv and treated with trypsin to remove previously adsorbed ma-positive material from the cell surface. synthesis of ma, vca and ea was completely blocked by puromycin. a marked reduction in the frequency of ma-positive cells was observed in the infected cell cultures in the presence of either ara-c or pa, but a fraction of the ma-positive cells was insensitive to the inhibit ... | 1978 | 215521 |
| heterogeneity of epstein-barr virus derived from p3hr-1 cells. | infection of cells of the ebv-free human b-lymphoma lines bjab and ramos resulted in conversion of these cells to ebv-genome carriers expressing ebna. ebv isolates from p3hr-1 cells induced a heterogeneous ebna pattern: both a faintly granular pattern and brilliant ebna-expression were observed. the two types of ebna-expressing cells could be separated upon cloning. brilliantly ebna-expressing cells always segregated varying percentages of ebna-negative cells. an ebna-negative subclone derived f ... | 1978 | 215522 |
| expression of latent epstein-barr virus genomes in human epithelial/burkitt's lymphoblastoid hybrid cells. | expression of latent epstein-barr virus genomes in somatic-cell hybrids of burkitt's lymphoblastoid cells has been studied. treatment of the hybrid cells, d98/raji and d98/hr-1, with iudr induced the formation of ea and vca and replication of virus dna, whereas the same treatment of raji cells induced only the formation of ea. the patterns of transcription of virus genomes in these three cell lines were, however, very similar: 25% without treatment with iudr, 30% immediately after the treatment ... | 1978 | 215523 |
| interaction between epstein-barr virus and type-c virus in human cells. | the interaction between ebv and type-c viruses was studied in our fvnc experimental system, in which ebv and type-c viral genomes are contained in each cell. the data indicate that the human lymphoid fvnc cells are sensitive to both ebv and type-c virus exposure, showing high frequencies of induction of both repressed viral genomes. the two different viral genomes may be associated with different chromosomes in individual cells. | 1978 | 215524 |
| epstein-barr virus-related serology in nasopharyngeal carcinoma and controls. | 1978 | 215525 | |
| clinical evaluation of ebv serology in american patients with nasopharyngeal carcinoma. | there is now extensive immunological, biological and biochemical evidence to support a possible etiological relationship between ebv and npc in patients from different geographical locations. besides providing information on the question of etiology, the results from immunological investigations suggest that antibodies to some of the ebv-associated antigens might also be of clinical importance in the diagnosis and prognosis of npc. to determine the possible clinical application of ebv serology t ... | 1978 | 215526 |
| the genetic and antigenic basis for the iga antibody response to epstein-barr viral capsid antigen. | 1978 | 215527 | |
| presence of epstein-barr virus specific iga in saliva of nasopharyngeal carcinoma patients: their activity, origin and possible clinical value. | 1978 | 215528 | |
| differences in ebv antibody titres of patients with nasopharyngeal carcinoma originating from high, intermediate and low incidence areas. | in order to assess the differences in serological reactivities of npc patients from high, intermediate and low incidence areas, 288 npc sera from hong kong, singapore, tunis, east africa, paris and los angeles, together with sera from patients with ear, nose and throat tumours other than npc and with those from normal individuals from the same areas, were tested 'blind' with the same batches of antigen. important differences (up to 3-fold) in the gmts of antibodies directed against vca, ea and e ... | 1978 | 215529 |
| cell-mediated immunity, epstein-barr virus and nasopharyngeal carcinoma. | cellular immunity is apparently important in host defenses against cancer. a growing body of information on cmi to ebv is here reviewed, providing a strong basis for studies of such reactivity in npc. present work suggests that cmi responses to virus- and tumour-associated antigens may have implications for etiology, diagnosis and treatment. | 1978 | 215530 |
| general immunological status of nasopharyngeal carcinoma patients in singapore. | newly diagnosed npc patients were found to have impaired general t-cell functions, as determined in vivo by the mantoux test and in vitro by the pha response assay. treated remission patients were as hyporesponsiveness as newly diagnosed patients. pha hyporesponsiveness was associated with the hla profile of a2-b sin 2 and with high antibody titres to ebv-related antigens, in particular to the early antigen. impaired responses in the mantoux or pha tests were associated with poor survival. the i ... | 1978 | 215531 |
| autoantibodies (cold lymphocytotoxins, antiactin antibodies and antinuclear factors) in nasopharyngeal carcinoma patients. | lta, sma and ana were found at higher frequencies in sera from npc patients than in those from matched controls. the frequency and gmts of lta-positive sera varied with the origin of the patient (chinese greater than north african greater than caucasian, thus paralleling the risk for npc in each ethnic group) and the stage of the disease (stage iv greater than stage i). a positive correlation was found between lta and anti-ebv titres with regard to anti-vca and anti-ebna antibodies. sma were spe ... | 1978 | 215532 |
| in vivo cell-mediated immunity in chinese patients with nasopharyngeal carcinoma. | delayed hypersensitivity to antigens derived from four ebv-related (khly 28, raji, f265 and nc37) and one ebv-unrelated (molt) t-lymphoid cell lines and to standard antigens (trichophyton, candida albicans and streptokinase/streptodornase) was measured in 104 npc patients and 24 patients with other cancers. of the npc patients with non-disseminated disease, 55/86 (63.2%) had a positive skin reaction to hkly 28 extract, compared with only 1/18 (5.6%) oc patients with non-disseminated disease. the ... | 1978 | 215533 |
| use of immunological studies in evaluating the clinical course of nasopharyngeal carcinoma. | the prognosis of a npc patient is influenced by many factors, including the therapeutic method used and the clinical stage and histological characteristics of the tumour. the immune response of the peripheral lymphocytes was examined in 27 patients with npc, and it was concluded that this response accurately indicates the clinical course of the diseases as compared with clinical stage of disease, histological type of tumour and anti-vca-antibody titre. | 1978 | 215534 |
| nasopharyngeal carcinoma: etiology and control. recommendations. | 1978 | 215535 | |
| animal models for nasopharyngeal carcinoma. | 1978 | 215536 | |
| integration of epstein-barr virus dna. | the application to herpesviruses of different standard methods fo measuring tumour-virus integration is discussed. the evidence for the presence of integrated virus dna in ebv-transformed cells is summarized. | 1978 | 221323 |
| herpesvirus papio: state of viral dna in baboon lymphoblastoid cell lines. | baboon lymphoblastoid cell lines (lcl) transformed with herpesvirus papio were evaluated for the state of hvp dna in the cells by caesium chloride density-gradient centrifugation and dna-crna filter hybridization. five hvp producer cultures and one non-producer culture were studied and non-integrated and integrated hvp dna were detected in all producer cultures whereas only integrated hvp dna could be demonstrated in the non-producer lcl. non-integrated hvp dna had a density of 1.715--1.716 g/cm ... | 1978 | 221325 |
| similarities and differences between various herpesviruses: a review. | 1978 | 221327 | |
| isolation of the epstein-barr virus nuclear antigen from chromatin preparations. | 1978 | 221330 | |
| epstein-barr virus genomes and their biological functions: a review. | 1978 | 221334 | |
| studies on epstein-barr virus dna polymerase activities in various human lymphoblastoid cell lines. | 1978 | 221344 | |
| identification and partial purification of two ebv-associated dna polymerases. | virally induced dna polymerases have been demonstrated in cells infected with a variety of herpesviruses. these include herpes simplex virus (weissbach et al., 1973), marek's disease virus (boezi et al., 1974), equine herpesvirus (allen et al., 1977), and cytomegalovirus (huang, 1975a). recently a new iododeoxyuridine (iudr)-induced intracellular dna polymerase in an epstein-barr virus (ebv)-producing hybrid cell line has also been reported (miller et al., 1977). we present evidence that there a ... | 1978 | 221345 |
| transformation of non-lymphoid cells by herpesviruses: a review. | 1978 | 221349 | |
| transformation of lymphoid cells by herpesviruses: a review with special reference to the phenotypic properties of transformed cells. | 1978 | 221350 | |
| mapping of putative transforming sequences of ebv dna. | the linkage of restriction enzyme fragments of dna of the b95-8 strain of epstein-barr virus has been determined. two approaches are being employed to define which ebv dna sequences are needed to initiate and maintain the transformation of lymphocytes to lymphoblasts capable of long-term growth in culture. the first approach is to determine the differences between the dna of strains of ebv which possess transforming capacity and the dna of the hr-1 strain which cannot transform. the data indicat ... | 1978 | 221358 |
| in vitro lymphocyte transformation by epstein-barr virus (ebv)-like viruses isolated from old-world non-human primates. | ebv-like viruses and lymphoid cell lines have been isolated from baboons and an orangutan. the cell lines have properties of b- or undifferentiated lymphocytes and have antigens and dna related to those of ebv. the baboon virus has a broad in vitro transformation host range among lymphocytes of old-world simian species whereas the orangutan isolate has a narrower host range. baboon and orangutan viruses as well as ebv have shown transforming activity for gibbon lymphocytes. baboon virus is infec ... | 1978 | 221359 |
| transcription of epstein-barr virus genomes in human lymphoblastoid cells and in somatic-cell hybrids of burkitt's lymphoma. | expression of latent epstein-barr virus genomes in lymphoblastoid cells and somatic-cell hybrid of burkitt's lymphoblastoid cells has been studied. iudr treatment induced the formation of early antigen (ea), virus capsid antigen (vca) and virus dna replication in d98/raji and d98/hr-1 cells whereas only ea was induced in raji cells. hr-1 clone no. 9 did not respond to iudr treatment. the pattern of transcription of virus genomes in these cell lines without iudr treatment was uniform with 20--25% ... | 1978 | 221360 |
| studies on the association of the epstein-barr virus genome with chromosomes in human (burkitt)/mouse hybrid cells. | we have used somatic-cell hybrids of mouse fibroblast and burkitt's lymphoblastoid tumour cells to continue our investigation of the association between epstein-barr virus (ebv) genome and human chromosomes. a mouse/burkitt hybrid cell, designated cl1d/hr-1, was cloned in soft agar. each of 10 clones was assayed for the spontaneous expression of ebv-associated nuclear antigen (ebna), early antigen (ea) and virus capsid antigen (vca). six of 10 clones were ebna-positive but negative for ea and vc ... | 1978 | 221361 |
| establishment of somatic hybrid cell clones from rat embryonic fibroblast cells with burkitt's lymphoblastoid cells using polyethylene glycol. | 1978 | 221362 | |
| provisional classification of herpesviruses: herpesvirus study group of the international committee for the nomenclature of viruses. | 1978 | 221375 | |
| priorities and needs in ebv research. | 1978 | 221379 | |
| inhibition of epstein-barr virus transformation: evidence for a block between ebna production and cell proliferation. | non-adherent lymphocyte populations prepared from donors with previous ebv infection transformed in the usual way in response to ebv. however, transformation was completely inhibited in the presence of adult but not fetal human fibroblasts. such inhibition was associated with lymphocytes from donors with prior ebv infection, but not from those without, and there appears to be an immunological basis for inhibition. inhibition was associated with production of ebna and was reversible. addition of ... | 1978 | 221385 |
| suppression of in vitro epstein-barr virus infection: a new role for adult human t-lymphocytes. | in vitro ebv infection of lymphocytes from different sources indicated that b-cells of adult peripheral or fetal cord blood transform with equal efficiency whether assayed by dna synthesis induction or immortalization. unfractionated adult lymphocytes transformed much less efficiently than those from fetal cord blood. this effect was due to the suppression of b-cell proliferation by adult t-lymphocytes. | 1978 | 221386 |
| surface glycoprotein patterns of human haematopoietic cell lines. | human ebv-positive and ebv-negative haematopoietic cell lines were shown to have different and easily distinguishable surface glycoprotein patterns as demonstrated using surface labelling by the galactose oxidase-tritiated sodium borohydride method. | 1978 | 221389 |
| persistent, chronic, and latent infections by herpesvirus: a review. | 1978 | 221391 | |
| pathogenesis of infectious mononucleosis, burkitt's lymphoma and nasopharyngeal carcinoma: a unified scheme. | 1978 | 221392 | |
| antibody-dependent autologous lymphocyte cytotoxicity against cells freshly transformed by epstein-barr virus. | cytotoxicity against lymphocytes freshly transformed by ebv was studied in an autologous system by trypan blue exclusion of ebna-positive cells and 51cr-release assay. when ebv-tranformed lymphocytes were incubated with ebv-positive serum and autologous unfractionated lymphocytes or k-cells from sero-positive healthy donors, the transformed cells were significantly damaged. the cytotoxicity against newly produced ebna-positive lymphocytes was also remarkable when sero-positive healthy donor lymp ... | 1978 | 221393 |
| inhibition by phosphonoacetate of the in vitro outgrowth of epstein-barr virus genome-containing cell lines from the blood of infectious mononucleosis patients. | 1978 | 221394 | |
| detection of epstein-barr virus-coded antigens in lymphocytes isolated from defined patient samples. | a preliminary report on the use of specific rabbit antisera raised to epstein-barr virus-coded antigens (ebna and ea) for detection of these antigens in vivo is presented. human lymphocytes were isolated on isokinetic gradients and the c3 receptor-bearing b-lymphocyte subpopulation was isolated, providing an enriched source of ebv-infected lymphocytes. such technology was employed to establish the status of the ebv host-cell complex in recurrent exudative tonsillitis (ret), infectious mononucleo ... | 1978 | 221395 |
| epstein-barr virus nuclear antigen (ebna)-positive cells in a lymph-node of a child with severe primary ebv infection. | 1978 | 221396 | |
| replication of epstein-barr virus dna in epithelial cells in vivo. | epstein-barr virus (ebv)-specific complementary rna (crna) was hybridized in situ to oropharyngeal epithelial cells taken from patients with infectious mononucleosis. cells from patients shedding virus in the throat hybridized signifnicant quantities of crna, whereas cells from ebv-negative sources did not. the degree of hybridization indicated a large ebv genome number per infected epithelial cell and suggested that these cells were the source of virus found in the throat. this finding may expl ... | 1978 | 221397 |
| comparison of immune responses and viral markers in herpesviruses-associated carcinomas: a review. | 1978 | 221405 | |
| comparison of humoral and cell-mediated responses and virus markers in herpesvirus-associated lymphomas: a review. | 1978 | 221406 |