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mixing at young ages reduces fighting in unacquainted domestic pigs.under normal farming practices, piglets from different litters are often mixed around the time of weaning, and a high incidence of fighting and minor injuries often occur. the aim of this experiment was to determine the effect of age on the incidence of fighting in piglets mixed before weaning, at different ages between 5 and 26 days. we found no significant relationship between age and the likelihood that a pair of piglets would fight during the first 75 min after mixing. however, the duration ...200010804264
effects of vasopressin and epinephrine on splanchnic blood flow and renal function during and after cardiopulmonary resuscitation in pigs.to compare the effects of vasopressin versus epinephrine on splanchnic blood flow during and after cardiopulmonary resuscitation (cpr), and to evaluate the effects of these vasopressors on renal function in the postresuscitation phase.200010809287
vasopressin decreases endogenous catecholamine plasma concentrations during cardiopulmonary resuscitation in pigs.the purpose of this study was to evaluate the effect of vasopressin vs. saline placebo on catecholamine plasma concentrations during cardiopulmonary resuscitation (cpr).200010809289
effect of phased chest and abdominal compression-decompression cardiopulmonary resuscitation on myocardial and cerebral blood flow in pigs.this study was designed to assess the effects of a phased chest and abdominal compression-decompression cardiopulmonary resuscitation (cpr) device, lifestick, vs. standard cpr on vital organ blood flow in a porcine cpr model.200010809291
bradykinin b2-receptor antagonism attenuates fatal cardiocirculatory breakdown induced by severe experimental pancreatitis.to investigate the impact of the long-acting bradykinin b2 receptor antagonist hoe 140 (icatibant) on survival time in a model of severe porcine pancreatitis.200010809293
pharmacokinetics and in vivo effects of a six-base phosphorothioate oligodeoxynucleotide with anticancer and hematopoietic activities in swine.a short phosphorothioate oligodeoxynucleotide telomere mimic with the sequence 5'-d(ttaggg)-3', tag-6, has been shown to inhibit telomerase activity and have antineoplastic and hematopoietic stimulatory properties. in this study, three immature male domestic swine (weighing approximately 40 kg) were administered 200 mg/m2 of tag-6 by continuous intravascular infusion at rates of 0.48 +/- 0.07 mg/hr for 14 days to evaluate the pharmacokinetics, toxicity, and tissue distribution. there was conside ...200010813533
somatostatin and somatostatin receptors in the pig pineal gland during postnatal development: an immunocytochemical study.an immunohistochemical study of the pineal gland of the domestic pig was carried out using rabbit antisera raised against synthetic peptide fragments corresponding to different amino acid sequences of the prosomatostatin, the somatostatin-14, and the somatostatin-28 molecule. the study was supplemented by immunohistochemical staining with rabbit antisera raised against five subtypes of somatostatin receptors. the pineal glands were taken from the newborn, 21-day-old and 7-month-old pigs. immunor ...200010820316
[dynamics and genetic determination of transformation of alpha macroglobulins allogroups in different populations of domestic pigs].the results of genetic studies of transformation of alpha-macroglobullin (am) allogroups (i.e., fixed allotype combinations) in pigs are presented. population and hybridization studies showed that the phenomenon discovered was based on activation/inactivation of the ami allotype expression, which depended on the genetic environment and interlocus relationships. genetic and selection bases, as well as the significance of the transformation phenomenon described, are discussed.200010822815
comparison of carbon dioxide laser, erbium:yag laser, dermabrasion, and dermatome: a study of thermal damage, wound contraction, and wound healing in a live pig model: implications for skin resurfacing.advances in laser technology allow for precise tissue removal and minimal thermal damage. however, mechanisms for cosmetic improvement have not been determined. investigators have suggested that ablation, collagen shrinkage, and new collagen deposition all contribute to the clinical outcome.200010607327
prevalence of antibody to hepatitis e virus among rodents in the united states.the recent identification of antibody to hepatitis e virus (hev) in pigs, sheep, and cattle and characterization of an hev isolated from domestic pigs suggest animal reservoirs for this virus. to investigate whether rodents might be a natural reservoir of hev, the prevalence of anti-hev was determined among a variety of species throughout the united states. serum samples were obtained from 806 rodents of 26 species in 15 genera. anti-hev prevalence was assessed by 2 eias (mosaic protein- and 55- ...200010669325
intestinal perfusion during pneumoperitoneum with carbon dioxide, nitrogen, and nitric oxide during laparoscopic surgery.to find out what effect insufflation pressure and type of gas have on intestinal perfusion during pneumoperitoneum.200010688221
the effect of continuous darkness and illumination on the function and the morphology of the pineal gland in the domestic pig. part i: the effect on plasma melatonin level.objectives: results of the majority of studies have revealed that diurnal changes in circulating melatonin level in the domestic pig differ from the typical patterns observed in other species. the aim of the present investigation was to study the effect of continuous darkness and continuous illumination on plasma melatonin in the pig. material and methods: the study was performed on three groups of immature gilts. the first group was kept under 14hrs light:10hrs dark cycle (500 lx of fluorescent ...200011455360
the effect of continuous darkness and illumination on the function and the morphology of the pineal gland in the domestic pig. part ii: the effect on pinealocyte ultrastructure.objectives: the characteristic feature of the pig pinealocytes is the presence of numerous membrane bounded bodies (mbb), which according to our previous results may be involved in the secretory activity. the present study was undertaken to analyze the effect of continuous darkness and illumination on the ultrastructure of the pig pinealocytes. material and methods: the study was performed on three groups of gilts. the first group (control) was kept under a cycle of 14hrs light (500 lx) and 10hr ...200011455361
age differences in thickness of the epidermis of miniature and domestic swine. 200011200562
median effective dose determination and histologic characterization of porcine (sus scrofa domestica) dermal lesions induced by 1540-nm laser radiation pulses.light amplification by stimulated emission of radiation (laser) systems operating in the so-called "eye safe" region are gaining widespread use in industry, medicine, and military applications. this research effort was geared to study the effects of laser tissue interaction on human skin by using in vivo porcine skin as an animal model. the goals of the study were to determine the median effective dose (ed50) for 1540-nm laser exposures, to evaluate the yorkshire pig and the yucatan mini-pig as ...200011200570
no evidence of infection with porcine endogenous retrovirus in recipients of encapsulated porcine islet xenografts.transplantation of pig tissues into humans has the potential for cotransferring pig infections. knowledge of the epidemiology of pig infections transmissible to humans allows the development of risk limitation strategies at the source herd level, but potentially infectious pig endogenous retrovirus (perv) is ubiquitous in all domestic pigs and therefore is not avoidable. using a specific and sensitive rt-pcr and nested pcr for perv nucleic acids with primers, the screening of pigs from new zeala ...200011202575
streptococcus suis meningitis, a poacher's risk.streptococcus suis infection is a zoonosis that has been mainly reported in pig-rearing and pork-consuming countries. the most common disease manifestation is meningitis, often associated with cochleovestibular signs. the causative agent is streptococcus suis serotype 2, found as a commensal in the tonsils of its natural host, the pig. persons at risk are mostly those with an occupational exposure to domestic pigs or their meat products. a case of meningitis caused by streptococcus suis in a poa ...200011205632
loteprednol etabonate: a soft steroid for the treatment of allergic diseases of the airways.there are several approaches for developing new antiallergic/antiasthmatic agents. one of them is the improvement of an existing class of effective drug classes. due to some undesired effects of intranasal or inhaled corticosteroids, there is a need for better tolerated corticosteroids. loteprednol etabonate belongs to the so-called class of soft steroids because it is metabolized by a one-step reaction (hydrolysis) without using the cytochrome p450 monooxygenase system. in in vitro investigatio ...200012861354
[modulation of nerve growth factor on wound healing of burn].to investigate the effect of nerve growth factor(ngf) on the burn wound healing and to study the mechanism of burn wound healing.200012516472
molecular variation of taenia solium in the world.complete nucleotide sequences of the mitochondrial cytochrome b (cytb) and cytochrome c oxidase subunit i (co i) genes from various isolates of taenia solium were examined. eleven isolates were analyzed; two isolates from china, two isolates from indonesia, one isolate each from india, thailand, mexico, ecuador, peru, mozambique and tanzania. in both genes, two isolates from indonesia shared the same sequences. similarly, the isolate from mexico shared same sequences with that from peru, and the ...200112041611
evaluation of the genetic variability of 13 microsatellite markers in native indian pigs.we analysed polymorphism of 13 microsatellites in two indian domesticated pig types (north indian and northeast indian). heterozygosity, polymorphism information content, and probability of identity of two random individuals were calculated for all microsatellites in both types. the number of alleles observed at a locus varied between five and 12. the evaluated microsatellites exhibited a very high heterozygosity and polymorphism information content. the probability of identity of two random ind ...200111988634
gastrointestinal transit of dosage forms in the pig.the gastrointestinal transit of liquid, pellet and tablet formulations was measured under fasted conditions in the domestic pig (n = 4) using the technique of gamma scintigraphy. the mean times for 50% gastric emptying for liquid and pellet systems were 1.4 and 2.2 h, respectively; tablets emptied between 1.5 and 6.0 h. total transit times were in the order of 50 h. these data conform well to published values for the transit of liquid and solid food materials in the pig. the times are much short ...200111206190
habituating pigs for in-pen, non-invasive biophysical skin analysis.the purpose of this study was to develop a method for habituating pigs (sus scrofa domestica, middle white strain) to enable non-invasive, biophysical measurements of dorsal skin to be obtained on a daily basis over a 7-week period, thus eliminating the need for anaesthesia or restraint. this was accomplished by associating measurements of transepidermal water loss (tewl) and skin reflectance spectroscopy (srs) with feeding times, and with positive reinforcement by allowing exercise outside the ...200111459406
oxidative state and histological changes in muscles of mastication after conditioning training.stress due to endurance training of striated muscles leads to adaptive changes in the distribution of muscle fiber types (i.e. ratio of type i and type ii fibers). moreover, severe training leads to tissue hypoxia and oxidative stress in muscles. in the current study, we examined the relationship between histological changes and oxidative state in muscles of mastication during the acute adaptation phase to a sustained muscle load. six domestic pigs received build-ups on the molar teeth in order ...200111370740
inhibition of nitric oxide improves coronary perfusion pressure and return of spontaneous circulation in a porcine cardiopulmonary resuscitation model.during spontaneous circulation, nonspecific inhibition of nitric oxide synthase by n(g)-nitro-l-arginine methyl ester (l-name) increases systemic vascular resistance and, therefore, mean arterial pressure. if this effect can be extrapolated to cardiopulmonary resuscitation (cpr), administering l-name during cpr may be beneficial by maintaining or even improving coronary perfusion pressure, and hence successful defibrillation.200111373408
localization of nadph-diaphorase activity in the pineal gland of the domestic pig.the study showed the presence of nadph-diaphorase containing structures in the pineal gland of the domestic pig. nadph-diaphorase activity was found in the nerve fibers and in the endothelial cells of the vasculature. the nerve fibers were localized in the capsule, around the blood vessels as well as in the parenchyma. the positive staining was not observed in the pig pinealocytes.200111374815
birth weight variation in the domestic pig: effects on offspring survival, weight gain and suckling behaviour.in domestic pigs, litter-mates often vary considerably in birth weight. to examine whether this size variation influences piglet survival, weight gain and suckling behaviour, we experimentally manipulated the number and size distribution of litter-mates in 51 litters. litters were small (eight or nine piglets) or large (11 or 12 piglets) compared to the herd mean of 10 piglets, and were made more or less variable in weight by using the largest and smallest quartiles of two combined litters (vari ...200111376836
are macrophages involved in early myocardial reperfusion injury?neutrophils are the predominant phagocytes in the early stages of myocardial ischemia-reperfusion response and are also implicated in the development of tissue damage. this study examined the role of recruited macrophages in the evolution of this tissue injury.200111383806
transgenic porcine valves show no signs of delayed cardiac xenograft rejection.glutaraldehyde fixation stiffens the structural integrity of porcine valves, although the solution also destroys tissue viability and accelerates calcification. recently, we demonstrated that fresh cardiac valves from domestic pigs do not express the galactose alpha1, 3 galactose (alpha-gal) antigen and may be immunologically unique. the absence of alpha-gal explained why the valves remained pristine while the rest of the porcine heart was destroyed by primate immunoglobulin m (igm) and compleme ...200111388231
decreased porcine valve antigenicity with in vitro culture.porcine valvular prostheses may stimulate inflammation after implantation, with resultant accelerated structural degeneration. we investigated the expression of porcine major histocompatibility complex (mhc) class ii molecules on valve leaflets and the possibility of decreasing valve antigenicity with in vitro culture.200111388232
rearrangement of the genes of vesicular stomatitis virus eliminates clinical disease in the natural host: new strategy for vaccine development.gene expression among the nonsegmented negative-strand rna viruses is controlled by distance from the single transcriptional promoter, so the phenotypes of these viruses can be systematically manipulated by gene rearrangement. we examined the potential of gene rearrangement as a means to develop live attenuated vaccine candidates against vesicular stomatitis virus (vsv) in domestic swine, a natural host for this virus. the results showed that moving the nucleocapsid protein gene away from the si ...200111390612
hepatic oxygen exchange and energy metabolism in hyperdynamic porcine endotoxemia: effects of the combined thromboxane receptor antagonist and synthase inhibitor dttx30.we compared the effects of thromboxane receptor antagonist and synthase inhibitor dttx30 on systemic and liver blood flow, oxygen (o2) exchange and energy metabolism during 24 h of hyperdynamic endotoxemia with untreated endotoxemia.200111396287
surgical organ perfusion method for gene transfer into cells of the perifollicular area of the spleen: an experimental trial on farm pigs.in an attempt to develop a gene therapy method for splenic and systemic diseases, an evaluation was made of surgical methods for gene transfer into porcine spleen. we have developed a continuous closed-circuit organ perfusion method for gene transfer into porcine spleen. for gene transfer, we used a type-5 replication defective adenovirus vector expressing the e. coli beta-galactosidase gene as a reporter gene. in eight young 22-35 kg farm pigs, the spleen was perfused in vivo with the viral sol ...200111465343
tracing nitrate transport and environmental impact from intensive swine farming using delta nitrogen-15.natural-abundance delta15n showed that nitrate generated from commercial land application of swine (sus scrofa domesticus) waste within a north carolina coastal plain catchment was being discharged to surface waters by ground water passing beneath the sprayfields and adjacent riparian buffers. this was significant because intensive swine farms in north carolina are considered non-discharge operations, and riparian buffers with minimum widths of 7.6 m (25 ft) are the primary regulatory control on ...200111476493
regional bone mass measurement from whole-body dual energy x-ray absorptiometry scan.there are no data on the relative accuracy and precision of regional bone mass measurement from whole-body dual energy x-ray absorptiometry (dxa) scans in small young subjects. twelve domestic swine piglets (2550-17,660 g) were scanned on a single-beam and on a fan beam densitometer using each humerus and femur as the region of interest to determine the validity of five different scan modes: two infant whole body (iwb), two spine, and one rat whole body (rwb) scan mode in the determination of re ...200111477306
successful repair of esophageal injury using an elastin based biomaterial patch.an esophageal injury with significant tissue loss is very difficult to repair. we conducted an in vivo study to test our elastin based acellular biomaterial patch to repair such defect. the patch was made from porcine aorta, by decellularization and sterilization. collagen fibers were preserved to retain mechanical strength and enhance cellular in-growth. ten domestic pigs underwent right thoracotomy. a 2 cm circular defect was made on the distal esophagus, excising half its circumference, and w ...200111482483
effects of biphasic vs monophasic defibrillation on the scaling exponent in a swine model of prolonged ventricular fibrillation.mathematical analyses of ventricular fibrillation (vf) have resulted in the derivation of a measure termed the scaling exponent (sce) that characterizes the duration of vf and probability of defibrillation success. the purpose of this study was to compare the effects of biphasic defibrillation waveform (bdw) and monophasic defibrillation waveform (mdw) rescue shocks on sce in a swine model of prolonged vf.200111483451
verification of good production practices that reduce the risk of exposure of pigs to trichinella.control of trichinella infection in swine has traditionally been accomplished by inspection of individual carcasses or by post-slaughter processing to inactivate parasites. recent declines in prevalence of this parasite in domestic swine, coupled with improvements in swine management systems, offer the opportunity to document pork safety during the production phase. we report here on a certification pilot study using an audit to document good production practices for swine relative to the risk o ...200111484365
evaluation of two pcr-based techniques for molecular epidemiology in finland, a high-endemic area with four sympatric trichinella species.trichinella larvae collected from wildlife, domestic and synanthropic animals in finland were identified to species by two molecular techniques: random amplified polymorphic dna (rapd) polymerase chain reaction (pcr) and the recently described multiplex pcr. the rapd-pcr was very sensitive to the sub-optimal preservation muscle larvae and resulting in weak and smeared bands on the gels for such material. however, the same samples yielded easily recognizable bands in the multiplex pcr; this latte ...200111484379
present status of trichinellosis in yugoslavia: serbia.trichinellosis was recognized almost one century ago as a health and animal husbandry problem in serbia. in the last 10 years, trichinellosis has been expanding from three endemic regions (srem, macva and negotinska krajina) to neighbouring regions. the infection rate detected by veterinary inspection in 1999 year was 0.17% in slaughtered swines. simultaneously, the number of infected humans increased three-five times in comparison with the period 1980-1990. for instance, 555 individuals were re ...200111484397
genetic relationship amongst the major non-coding regions of mitochondrial dnas in wild boars and several breeds of domesticated pigs.we completed phylogenetic analysis of the major non-coding region of the mitochondrial dna (mtdna) from 159 animals of eight euro-american and six east asian domesticated pig breeds and 164 japanese and five european wild boars. a total of 62 mtdna haplotypes were detected. alignment of these regions revealed nucleotide variations (including gaps) at 73 positions, including 58 sites with transition nucleotide substitutions, and two transversion substitutions. phylogenetic analysis of the sequenc ...200111493262
plasma melatonin levels in relation to the light-dark cycle and parental background in domestic pigs.to study porcine melatonin secretion in a stable environment 3 daytime (10.00-15.00) and 3 nighttime (22.00-03.00) plasma samples were collected by jugular venipuncture from 15 gilts, 16 sows, 3 boars and 48 piglets (24 females and 24 males from 8 litters) and analysed for melatonin content. nighttime melatonin concentrations were higher than daytime melatonin concentrations (p < 0.001), whereas no effect of sampling order could be discerned. the 3 adult hampshire boars had higher melatonin conc ...200111503374
local delivery of paclitaxel using the double-balloon perfusion catheter before stenting in the porcine coronary artery.paclitaxel is a new cancer chemotherapeutic agent that has been approved for clinical use in patients with a variety of different cancers. paclitaxel inhibits cell proliferation by an action on microtubules. the aim of this study was to evaluate the safety and efficacy of locally delivered paclitaxel after coronary stent implantation. a novel double-balloon perfusion catheter was used to deliver the drug locally in the pig coronary artery. twenty-seven domestic pigs underwent stent implantation ...200111515014
veterinary aspects of alveolar echinococcosis--a zoonosis of public health significance.human alveolar echinococcosis (ae), caused by the metacestode stage of echinococcus multilocularis, is a serious zoonosis which caused up to 100% lethality in untreated patients before the 1970s, when modern methods of treatment were not yet established. ae occurs in large areas of the northern hemisphere mostly with low country-wide prevalences, but high prevalences of up to 4% have been reported from small population groups in highly endemic foci, e.g. from china. ae includes many veterinary a ...200111516580
improving standard cardiopulmonary resuscitation with an inspiratory impedance threshold valve in a porcine model of cardiac arrest.to improve the efficiency of standard cardiopulmonary resuscitation (cpr), we evaluated the potential value of impeding respiratory gas exchange selectively during the decompression phase of standard cpr in a porcine model of ventricular fibrillation. after 6 min of untreated cardiac arrest, anesthetized farm pigs weighing 30 kg were randomized to be treated with either standard cpr with a sham valve (n = 11) or standard cpr plus a functional inspiratory impedance threshold valve (itv(tm)) (n = ...200111524335
coronary vasa vasorum neovascularization precedes epicardial endothelial dysfunction in experimental hypercholesterolemia.experimental hypercholesterolemia is associated with vasa vasorum neovascularization, unknown to occur before or after initial lesion formation. thus, this study was performed to determine the temporal course of neovascularization of coronary vasa vasorum in relation to endothelial dysfunction, a hallmark of early atherosclerosis.200111530109
study of lobation and vascularization of the lungs of wild boar (sus scrofa).the purpose of this study was to describe the anatomy of the lungs of wild boars for comparison with those of domestic swine. it was found that the right lung of the wild boar is divided into four lobes: cranial, median, caudal and accessory, whereas the left lung is divided into two lobes: cranial and caudal. in 93.4% of the cases, right pulmonary artery separates into the ascendant, descendant, median, accessory and caudal branches. in 73.3% of the cases, left pulmonary artery separates most f ...200111534325
sarcocystis miescheriana infection in domestic pigs (sus scrofa) in the philippines.sarcocystis miescheriana sarcocysts were identified in skeletal muscles of 9 (27%) of 33 swine slaughtered for human consumption. sarcocysts were 144-180 microm x 20-38 microm in size. ultrastructurally, the cyst wall resembled the type 10 sarcocyst wall. the villar protrusions (vp) were 3-4.5 microm long and 0.6-1.2 microm wide and had prominent longitudinally arranged microtubules extending from the vp tips to the granular layer (=ground substance). the parasitophorous vacuolar membrane with i ...200111534668
a comparison of biphasic and monophasic waveform defibrillation after prolonged ventricular fibrillation.to compare the effects of biphasic defibrillation waveforms and conventional monophasic defibrillation waveforms on the success of initial defibrillation, postresuscitation myocardial function, and duration of survival after prolonged duration of untreated ventricular fibrillation (vf), including the effects of epinephrine.200111555534
ventriculocoronary artery bypass results using a mesh-tipped device in a porcine model.in this report we describe the in vivo evaluation of a device and ventriculocoronary artery bypass procedure that creates a permanent transmyocardial channel between the left ventricle and a coronary artery.200111565716
linear prediction coding analysis and self-organizing feature map as tools to classify stress calls of domestic pigs (sus scrofa).it is assumed that calls may give information about the inner (emotional) state of an animal. hence, in the last years sound analysis has become an increasingly important tool for the interpretation of the behavior, the health condition, and the well-being of animals. a procedure was developed that allows the characterization, classification, and visualization of the cluster structures of stress calls of domestic pigs (sus scrofa). based on the acoustic model of the sound production the extracti ...200111572353
molecular epidemiology of classical swine fever in italy.to gain an insight into the molecular epidemiology of classical swine fever (csf) in italy, virus isolates originating from outbreaks that occurred between 1985 and 2000 in wild boar or in domestic pigs in mainland italy and in sardinia were analysed by genetic typing. for this, a fragment (190 nucleotides) of the e2 glycoprotein gene was sequenced and phylogenetic analyses were performed, including older italian isolates and isolates from recent outbreaks in europe for comparison. the results s ...200111574170
african swine fever virus infection of porcine aortic endothelial cells leads to inhibition of inflammatory responses, activation of the thrombotic state, and apoptosis.african swine fever (asf) is an asymptomatic infection of warthogs and bushpigs, which has become an emergent disease of domestic pigs, characterized by hemorrhage, lymphopenia, and disseminated intravascular coagulation. it is caused by a large icosohedral double-stranded dna virus, african swine fever virus (asfv), with infection of macrophages well characterized in vitro and in vivo. this study shows that virulent isolates of asfv also infect primary cultures of porcine aortic endothelial cel ...200111581405
melatonin potentiates the vasoconstrictive effect of noradrenaline in renal artery from newborn hooded seals (cystophora cristata) and harp seals (phoca groenlandica).isometric tension was recorded by force displacement transducers in ring segments of the inferior branch of the renal artery from newborn hooded seals (cystophora cristata, n=6), harp seals (phoca groenlandica, n=3) and domestic pigs (sus scrofa f. domestica, n=5). arterial segments were mounted in heated organ baths and exposed to graded concentrations of noradrenaline (na) and adrenaline (a), alone or together with melatonin. the melatonin concentration in the bath was similar to the plasma co ...200111585261
laparoscopic bladder flap ureteral reimplantation: survival porcine study.the bladder or boari flap is a useful technique for ureteroneocystostomy when the distal ureter is too short to reach the bladder without undue tension. we report our experience with laparoscopic boari flap ureteroneocystostomy in the chronic porcine model.200111586261
cytochrome b gene for species identification of the conservation animals.a partial dna sequence of cytochrome b gene was used to identify the remains of endangered animals and species endemic to taiwan. the conservation of animals species included in this study were: the formosan gem-faced civets, leopard cats, tigers, clouded leopards, lion, formosan muntjacs, formosan sika deers, formosan sambars, formosan serows, water buffalo, formosan pangolins and formosan macaques. the control species used included domestic cats, domestic dogs, domestic sheeps, domestic cattle ...200111587860
comparison of aerosolized gadoteridol and gadopentetate dimeglumine for magnetic resonance ventilation imaging of the lung.the purpose of this study was to compare aerosolized gadoteridol and gadopentetate dimeglumine in regard to homogeneity of aerosol distribution and relative pulmonary signal intensity (si) changes after a 10-min mechanical ventilation period. twenty experimental procedures were performed in 10 intubated domestic pigs that were mechanically aerosolized with the nebulized contrast medium. images were obtained by using a respiratory-gated t(1)-weighted tse sequence. pulmonary si increase for the ri ...200111590658
three-dimensional mr pulmonary perfusion imaging and angiography with an injection of a new blood pool contrast agent b-22956/1.initial evaluation of a new blood pool agent, b-22956/1, for pulmonary imaging was performed in five domestic pigs with artificial embolism. pre-embolism 3d pulmonary perfusion images were first acquired by injecting an extravascular agent, gadoteridol. the pulmonary arteries of the pigs were then occluded by the artificial emboli. post-embolism perfusion scans were subsequently performed by injecting b-22956/1. additional post-embolism high-spatial-resolution angiograms were also acquired. pare ...200111599067
functional comparison of transmyocardial revascularization by mechanical and laser means.as a result of the clinical benefit observed in angina patients treated by transmyocardial revascularization (tmr) with a laser, interest in mechanical tmr has been renewed. although the injury induced by mechanical tmr is similar to laser tmr, the resultant impact on myocardial contractility is unknown. the purpose of this study was to determine whether mechanical tmr improves ventricular function as compared with laser tmr in chronically ischemic myocardium.200111789783
ocular fluorescein kinetics before and after vitrectomy on swine.to study the quantitative effects of vitrectomy on fluorescein transport kinetics across the ocular barriers.200111789863
gut luminal lactate release during gradual intestinal ischemia.gut ischemia induced by occlusion of the superior mesenteric artery (sma) results in release of lactate into the gut lumen. we studied the threshold of sma flow reduction that leads to increased gut luminal lactate during stepwise reduction in sma blood flow.200111797028
molecular phylogenetics relationship between six chinese native pig breeds and three swedish pig breeds from mitochondrial dna.mitochondrial dna genetic polymorphisms were used to evaluate the relationship between 6 chinese indigenous pig breeds and 3 swedish domestic pig breeds. a total of 440 bp of the control region and 798 bp of cytochrome b (cyt b) gene of mtdna were determined from 140 pigs of 9 different breeds. the results of phylogenetics analysis showed that 6 chinese native pig breeds originated from the asian wild boar. the pairwise nucleotide sequences divergence suggested that they might occur about 413,00 ...200111797341
optimizing timing of ventricular defibrillation.our intent was to evolve a prognosticator that would predict the likelihood that an electrical shock would restore a perfusing rhythm. such a prognosticator was to be based on conventional electrocardiographic signals but without constraints caused by artifacts resulting from precordial compression. the adverse effects of "hands off" intervals for rhythm analyses would therefore be minimized. such a prognosticator was further intended to reduce the number of electrical shocks and the total energ ...200111801840
[risk factors for human african trypanosomiasis in the bipindi region of cameroon].in the course of two surveys carried out at the end of 1998 and beginning of 1999, sleeping sickness was diagnosed in a total of 43 people in the bipindi region of cameroon. this observation led us to investigate the mechanisms of transmission of human african trypanosomiasis in the epicentrer of the outbreak. a case-control study showed a particularly high risk of infection associated with hunting activities (odds-ratio: 2.87; ci 95%: 0.96-9.52). interpretation of this finding in the light of l ...200111803830
[intravascular detection of myocardial ischemia by spectrometry in the near infrared spectrum in experimental animals].interruption of oxygen supply in acute myocardial ischaemia reduces venous return of oxygen at the coronary sinus. in this study, the oxygen content of venous return in the coronary sinus was measured by using spectrometry in the near infrared spectrum. the authors developed a new intravascular catheter made of fibre optics. after in vitro calibration by blood flow based on a standard gas mixture used in in vitro experiment, an in vivo application in 12 domestic pigs was undertaken. the catheter ...200111603075
methyl-beta-cyclodextrin: an alternative carrier for intravenous infusion of palmitate during tracer studies in swine (sus scrofa domestica).fatty acid-free albumin has been the standard carrier for intravenous infusion of fatty acids to study in vivo lipid metabolism. however, subjects can have adverse reactions to infusion of albumin. we sought an alternative to albumin as a carrier for intravenous infusion of fatty acids, using the pig as a model. cyclodextrins are naturally occurring water-soluble molecules that can serve as carriers for lipid-soluble compounds. 13c-palmitate was complexed to either 20% methyl-beta-cyclodextrin, ...200111672683
revascularisation of costochondral grafts: an experimental study in domestic pigs.mandibular condyles are reconstructed immediately with costochondral grafts (ccgs) in children for several temporomandibular conditions, including ankylosis, benign neoplasia, and chronic arthritis. a prerequisite for growth of ccgs is that they are properly revascularised, but the revascularisation process has not to our knowledge so far been examined. the aim of the present study was therefore to investigate the revascularisation of ccgs when they were used for immediate reconstruction of the ...200111680393
growth of costochondral grafts in reconstruction of the mandibular condyle: an experimental study in domestic pigs.reconstruction of the mandibular condyle with costochondral grafts (ccgs) in children may result in overgrowth at the reconstructed side of the mandible. in this study we report on the effects of functional stimuli on growth and morphology of growth plates of ccgs used for immediate mandibular condyle replacement in 10 juvenile pigs. the mandibular condyles were resected unilaterally and immediately reconstructed with autogenous ccgs. another ccg was placed submuscularly on one tibia. the length ...200111680394
experimental evaluation of photocrosslinkable chitosan as a biologic adhesive with surgical applications.in various surgical cases, effective tissue adhesives are required for both hemostasis (eg, intraoperative bleeding) and air sealing (eg, thoracic surgery). we have designed a chitosan molecule (az-ch-la) that can be photocrosslinked by ultraviolet (uv) light irradiation, thereby forming a hydrogel. the purpose of this work was to evaluate the effectiveness and safety of the photocrosslinkable chitosan hydrogel as an adhesive with surgical applications.200111685194
morphometric characterization of the airway and vascular systems of the lung of the domestic pig, sus scrofa: comparison of the airway, arterial and venous systems.the bronchial system (bs), the pulmonary artery (pa) and the pulmonary vein (pv) of the lung of the domestic pig, sus scrofa were simultaneously cast with silicone rubber and studied. asymmetrical dichotomous bifurcation preponderated in the tree-like arrangement of the three conducting systems. lengths and diameters of the various generations were measured. at the extremities of the bs and the pa, alveoli and blood capillaries related very closely. in the cranial and middle lobes of the right a ...200111691614
morphological and histochemical characteristics of the lamina propria in scrotal and abdominal testes from postpubertal boars: correlation with the appearance of the seminiferous epithelium.this study was undertaken to investigate the morphological characteristics and lectin affinity of the testicular lamina propria in healthy boars and in unilateral and bilateral abdominal cryptorchid boars. the lamina propria of scrotal testes from healthy boars and unilateral cryptorchid boars was constituted by an innermost noncellular layer, the basal lamina, and by 2 layers of peritubular cells, each separated by a fibrous layer. the noncellular layers contained collagen fibres and glycoconju ...200111693304
acceptability of local made baits for oral vaccination of dogs against rabies in the philippines. 200111696244
transjugular intrahepatic portosystemic shunt with an autologous vein-covered stent: results in a swine model.to investigate the feasibility, safety, and efficacy of an autologous vein-covered stent (avcs) to prevent shunt stenosis in a porcine transjugular intrahepatic portosystemic shunt (tips) model.200111698634
selective aortic arch perfusion with hemoglobin-based oxygen carrier-201 for resuscitation from exsanguinating cardiac arrest in swine.the prospects for resuscitation after blunt traumatic cardiac arrest are dismal. selective aortic arch perfusion (saap) with a hemoglobin-based oxygen carrier (hboc-201) offers a potentially effective therapy. this study evaluated the acute cardiovascular and metabolic effects of saap with hboc-201 in an exsanguination model of cardiac arrest.200111700396
the pattern of melatonin secretion is rhythmic in the domestic pig and responds rapidly to changes in daylength.the aim of the study was to investigate the capability of pigs to respond to abrupt changes in lighting conditions by means of alterations in circadian melatonin profiles. sixteen pre-pubertal crossbred male pigs weighing 40-45 kg were housed in individual pens in four temperature- and lighting-controlled climate rooms (four pigs per room). in two rooms there was a light-dark cycle of 16 l:8 d (group a) and in two other rooms 8 l:16 d (group b). under both lighting regimens light intensity at pi ...200111703557
triggered electromyographic threshold for accuracy of thoracic pedicle screw placement in a porcine model.a porcine model of thoracic pedicle screw insertion was used to determine the effect of screw position on triggered electromyographic response.200111707715
comparison of renal ablation with cryotherapy, dry radiofrequency, and saline augmented radiofrequency in a porcine model.needle ablative therapy has recently generated a lot of interest in the urologic community. we compare renal lesions produced in a porcine model using three forms of needle ablative energy: cryoablation (cr), dry radiofrequency (rf), and saline augmented radiofrequency (sarf).200111708507
detection of porcine bone lesions and fissures: comparing digital selenium, digital luminescence, and analog film-screen radiography.the purpose of our study was to compare the diagnostic performance of a digital selenium detector (thoravision) with that of analog film-screen systems and digital luminescence radiography in skeletal radiography for the detection of fissures and lesions in porcine bones.200111717093
plasma epinephrine levels after epinephrine administration using different tracheal administration techniques in an adult cpr porcine model.the aim of the study was to compare arterial plasma epinephrine levels after tracheal epinephrine application using three different tracheal instillation techniques at different tracheal levels in a porcine adult cardiopulmonary resuscitation model. in the prospective, randomized study, electrically-induced cardiopulmonary arrest was applied to 32 anaesthetized and paralyzed domestic pigs. after 3 min of cardiopulmonary arrest and 2 min of external chest compressions using a pneumatic compressio ...200111719136
effects of epinephrine in a pig model of hypothermic cardiac arrest and closed-chest cardiopulmonary resuscitation combined with active rewarming.the aim of the current study was to assess the effects of epinephrine in a pig model of hypothermic cardiac arrest followed by closed-chest cardiopulmonary resuscitation combined with active rewarming, simulating the clinical management of an arrested hypothermic patient in a hospital without cardiopulmonary bypass facilities.200111719160
spinal cord metabolism during thoracic aortic cross-clamping in pigs with special reference to the effect of allopurinol.investigate the metabolic response of the spinal cord and the effect of allopurinol following cross clamping of the descending thoracic aorta in a porcine model.200111735178
use of a cardiocerebral-protective drug cocktail prior to countershock in a porcine model of prolonged ventricular fibrillation.this was the third study in a series exploring whether the use of combination pharmacotherapy with delayed countershock would produce higher rates of return of spontaneous circulation (rosc) and one-hour survival when compared with standard advanced cardiac life support (acls) therapy in prolonged ventricular fibrillation (vf).200111738783
[interstitial t1-weighted mr lymphography with use of the dendritic contrast agent gadomer-17 in pigs].to investigate the enhancement of regional lymph nodes, lymph vessels and the thoracic duct after subcutaneous administration of the dendritic contrast agent gadomer-17.200111740675
pancreatic tissue perfusion in experimental acute pancreatitis.to investigate pancreatic tissue perfusion and oxygenation in severe and mild experimental acute pancreatitis in pigs.200111759740
comparison of a new stent and wallstent for transjugular intrahepatic portosystemic shunt in a porcine model.to evaluate a new balloon-expandable stainless steel stent (cordis stent) in a transjugular intrahepatic portosystemic shunt (tips) porcine model and compared with wallstent.200111819736
effects of birth season, breed, sex, and sire family on cardiac morphology determined in pigs (sus scrofa domestica) by use of echocardiography.echocardiography played an important role in the screening and diagnosis of hypertrophic cardiomyopathy. in the study reported here, we attempted to evaluate the effects of birth season, breed, sex, and sire family on cardiac morphology determined in pigs by use of echocardiography.200111924818
stress response to cold in trichinella species.trichinella-type larvae (l(1)) are found in the muscles of infected wild animals and domestic pigs and are the cause of trichinosis in man and other animals throughout the world. these parasites are exposed to low temperatures during their life cycle. on this premise, three trichinella species of different types of habitat (the arctic t. nativa, the cosmopolitan t. spiralis, and the tropical t. nelsoni) were selected to examine the effect of a shift in temperature, from 37 to 4 degrees c, on lon ...200112009726
non-invasive measurement of blood pressures in the yucatan micropig (sus scrofa domestica), with and without midazolam-induced sedation.current literature suggests that the effects of midazolam, a water-soluble benzodiazepine, on blood pressure in swine are minimal. the hypothesis of the study reported here was that a light sedative dose would induce a decrease in blood pressure in this species. healthy female yucatan micropigs (n = 20), 16 to 30 (mean, 22) kg, aged four six months, were individually placed in a humane restraint sling and allowed to acclimate. systolic (sbp), diastolic (dbp), and mean (mbp) blood pressures (mmhg ...200111926295
pathogenesis of african swine fever virus in ornithodoros ticks.african swine fever virus (asfv) is the only known dna arbovirus and the sole member of the family asfarviridae. it causes a lethal, hemorrhagic disease in domestic pigs. asfv is enzootic in sub-saharan africa and is maintained in a sylvatic cycle by infecting both wild members of the suidae (e.g. warthogs) and the argasid tick ornithodoros porcinus porcinus. the pathogenesis of asfv in o. porcinus porcinus ticks is characterized by a low infectious dose, lifelong infection, efficient transmissi ...200111831434
demodex phylloides (acari, demodecidae) as a specific parasite of sus scrofa (mammalia, artiodactyla).within 1994-2000, sections of skin collected from eleven areas on the body of 650 wild boars and 85 pigs living in the northern poland and in the great poland were examined. the d. phylloides infestation in the wild boar was observed to be very heavy (prevalence 32%, mean intensity 74 ind.). in contrast, the domestic pig turned out to be free of the parasite. the wild boar d. phylloides infestations are symptomless. the parasite is relatively rare in the domestic pig, although the high animal de ...200116886429
diaspirin cross-linked hemoglobin fails to improve left ventricular diastolic function after fluid resuscitation from hemorrhagic shock.in severe hemorrhagic shock, left ventricular (lv) diastolic dysfunction is an early sign of cardiac failure due to compromised myocardial oxygenation. immediate fluid replacement or, in particular, administration of a hemoglobin-based oxygen carrier (diaspirin cross-linked hemoglobin; dclhb) improves myocardial oxygenation; therefore, positive effects on lv diastolic function could be expected. the effects of fluid resuscitation from severe hemorrhagic shock with dclhb were investigated in 20 a ...200111805391
a histologic analysis of three-dimensional versus two-dimensional tissue expansion in the porcine model.recently, a two-dimensional silastic dacron stretching skin device has been developed for scalp reduction surgery. attached subgaleally, this device stretches skin over time, while avoiding the visible volumetric distention that is typical of three-dimensional tissue expanders. unlike three-dimensional expanders, the histological changes observed with a two-dimensional stretching device have not been described in the literature. the present study compares the histological effects of two-dimensio ...200111192897
use of intraosseous blood for repeated hematologic and biochemical analyses in healthy pigs.to evaluate the clinical and histologic effects of repeated intraosseous (io) needle placement in domestic pigs and determine whether blood and serum obtained intraosseously could be used for cbc and biochemical analyses.200111197559
fasciolopsiasis: is it a controllable food-borne disease?fasciolopsiasis, endemic to the orient and southeast asia, is a snail-transmitted, intestinal, food-borne parasitic zoonosis caused by a trematode, fasciolopsis buski, which also infects farm pigs. fasciolopsiasis remains a public health problem despite changes in eating habits, alterations in social and agricultural practices, health education, industrialization, and environmental alterations. the disease occurs focally and is most prevalent in school-age children. in foci of parasite transmiss ...200111199855
seasonal alterations in circadian melatonin rhythms of the european wild boar and domestic gilt.the aims of the present study were: 1) to determine if the european wild boar exhibits a circadian pattern of melatonin secretion under its natural light environment; 2) to compare this pattern with the pattern in domestic pigs reared under the light environment typical for domesticity; and 3) to determine if there are seasonal alterations in melatonin rhythms. four to six young, pure-bred, european wild boars and four to six cross-bred (yorkshire x finnish landrace) domestic gilts were sampled ...200111168906
experimental infection of european wild boars and domestic pigs with pseudorabies viruses with differing virulence.to determine susceptibility of european wild boars (sus scrofa) to infection with pseudorabies virus (prv) and to characterize the virulence of a wildboar prv isolate for wild and domestic pigs.200111212035
mass closure technique: an experimental study on separation of wound edge.to study separation of wound edges in midline laparotomy incisions closed with either a mass stitch or a stitch incorporating only aponeurosis.200111213824
effect of vascular occlusion on radiofrequency ablation of the liver: results in a porcine model.this study determined the effect of vascular occlusion on radiofrequency lesion shape, volume, and temperature in a porcine liver model.200111222227
multiple groups of novel retroviral genomes in pigs and related species.in view of the concern over potential infection hazards in the use of porcine tissues and organs for xenotransplantation to humans, we investigated the diversity of porcine endogenous retrovirus (perv) genomes in the dna of domestic pigs and related species. in addition to the three known envelope subgroups of infectious gamma retroviruses (perv-a, -b, and -c), classed together here as perv group gamma 1, four novel groups of gamma retrovirus (gamma 2 to gamma 5) and four novel groups of beta re ...200111222700
comparative pathogenesis of infection of pigs with hepatitis e viruses recovered from a pig and a human.specific-pathogen-free pigs were inoculated with one of two hepatitis e viruses (hev) (one recovered from a pig and the other from a human) to study the relative pathogenesis of the two viruses in swine. fifty-four pigs were randomly assigned to three groups. seventeen pigs in group 1 served as uninoculated controls, 18 pigs in group 2 were intravenously inoculated with the swine hev recovered from a pig in the united states, and 19 pigs in group 3 were intravenously inoculated with the us-2 str ...200111230404
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