Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [stimulation of mucous glands of the respiratory tract by neuropeptides: comparison of exogenous administration and endogenous liberation]. | exogenous substance p is a powerful stimulant of tracheal gland secretion but the contribution of endogenous neuropeptides to neurogenic gland secretion is unknown. using the ussing chamber technique, we measured the secretion of radiolabeled macromolecules from submucosal glands in the ferret. neurokinins caused gland secretion through a neurokinin-1 (nk-1) receptor. gland secretion caused by electric field stimulation of postganglionic nerve endings was not inhibited by a substance p antagonis ... | 1990 | 1695001 |
| modulation of ca2+ transients and contractile properties by beta-adrenoceptor stimulation in ferret ventricular muscles. | 1. the mechanism of modulation of ca2+ transients and contraction by beta-adrenoceptor stimulation was studied in ferret ventricular muscles using aequorin to measure intracellular ca2+. 2. peaks of tension and light transients were increased by isoprenaline (10(-9) - 5 x 10(-7) m) which also abbreviated their time courses. 3. time-to-peak tension was significantly shortened by 5 x 10(-9) m-isoprenaline and time-to-peak light was abbreviated by 10(-9) m-isoprenaline. 4. the time for the light to ... | 1990 | 1696985 |
| excitation-contraction coupling model to estimate the recirculating fraction of activator calcium in intact cardiac muscle. | potentiated contractions were evoked with rapid pace pause maneuver in 14 length-clamped ferret papillary muscles paced 12 times/min at 25 degrees c. at 1.25 mm [ca2+]o the average steady-state force was 2.94 +/- 1.08 g/mm2 and the potentiated contraction averaged 10.96 +/- 1.61 g/mm2. at 5.0 mm [ca2+]o the steady-state force increased to 6.18 +/- 1.23 g/mm2 and the potentiated contraction averaged 12.08 +/- 1.15 g/mm2. under the conditions of these experiments the potentiated contraction obtain ... | 1990 | 1697217 |
| use of dna restriction endonuclease digest and ribosomal rna gene probe patterns to fingerprint helicobacter pylori and helicobacter mustelae isolated from human and animal hosts. | variation amongst strains of helicobacter pylori and helicobacter mustelae was examined by dna restriction endonuclease digestion and rrna gene patterns generated using a non-radioactive probe. chromosomal dna was extracted from 30 cultures of h. pylori from human, rhesus monkey and pig gastric mucosa, and from three h. mustelae isolates from ferret gastric mucosa. dna fingerprinting with hae iii and hind iii showed h. mustelae was relatively homogeneous but revealed genomic heterogeneity within ... | 1990 | 1698260 |
| development of the lateral geniculate nucleus: interactions between retinal afferent, cytoarchitectonic, and glial cell process lamination in ferrets and tree shrews. | we have studied the relationship of retinal afferents, glial cell processes, and neuronal cytoarchitectonics in the lateral geniculate nucleus (lgn) of two species: tree shrews (tupaia belangeri) and ferrets (mustela putoris). both species are relatively immature at birth, allowing the development of these features to be studied in the perinatal period. retinal afferents, visualized by intraocular injection of a wheat germ agglutinin/horseradish peroxidase conjugate (wga-hrp), are apparently the ... | 1990 | 1698826 |
| the topographic relationship between shifting binocular maps in the developing dorsal lateral geniculate nucleus. | the major mammalian subcortical visual structures receive topographically ordered projections from both eyes. in the adult dorsal lateral geniculate nucleus (dlgn) each projection terminates in separate restricted regions of the nucleus. this pattern is different during development. initially in ferrets the projections from each eye to the dlgn overlap throughout this structure. although the projections do not occupy regions that are appropriate given the adult pattern, they are both retinotopic ... | 1990 | 1704850 |
| somatodendritic morphology of on- and off-cells in the rostral ventromedial medulla. | the rostral ventromedial medulla (rvm) contains two classes of physiologically defined neurons, on-cells and off-cells, that are implicated in nociceptive modulation. in a continuing effort to detail the neural circuitry that underlies the activity of these two distinct neuronal types, the somatodendritic morphology of on- and off-cells was studied in the cat, rat, and ferret. in lightly anesthetized animals, on-cells increased and off-cells decreased their discharge rate during a withdrawal ref ... | 1990 | 1706357 |
| emesis-related biochemical and histopathological changes induced by cisplatin in the ferret. | cisplatin is an effective antineoplastic agent that causes severe vomiting due to unknown mechanism. the ferret, an animal model useful in the determination of emetic activity, was used to clarify the emesis-related biochemical and histopathological changes that were induced by cisplatin. cisplatin (5 to 10 mg/kg) was administered intraperitoneally and a 7-10 mg/kg i.p. dose evoked dose-dependent emesis in the ferret. almost all cisplatin-vomiting episodes occurred within a 6 hour observation pe ... | 1990 | 1707101 |
| immunocytochemistry of pancreatic endocrine tumors in three domestic ferrets (mustela putorius furo). | 1990 | 1972304 | |
| the actions of fenfluramine and interaction with 5-ht3 receptor-antagonists to inhibit emesis in the ferret. | the racemate and (+)- and (-)-isomers of fenfluramine (5 mg kg-1 i.p., 1 h pretreatment) antagonized cisplatin-induced retching and vomiting in the ferret. the intravenous injection of (+/-)-fenfluramine administered on an established cisplatin-induced emesis antagonized the response within minutes of injection. the administration of a lower dose of (+/-)-fenfluramine (1.0 mg kg-1 i.p., 1 h pretreatment) failed to antagonize cisplatin-induced emesis when administered alone but enhanced the antie ... | 1990 | 1972409 |
| fluphenazine, ics 205-930 and dl-fenfluramine differentially antagonise drug-induced emesis in the ferret. | the intravenous injection of cisplatin (10 mg/kg), the subcutaneous injection of apomorphine (0.125-1 mg/kg) and lisuride (0.001-0.1 mg/kg), the oral administration of ipecacuanha (0.3-2.4 mg/kg) and the intragastric administration of copper sulphate (25-100 mg/kg), induced a vomiting and retching response in the ferret. pretreatment with dl-fenfluramine (5 mg/kg i.p.) prevented or reduced the emesis induced by cisplatin, apomorphine, ipecacuanha and lisuride but failed to significantly antagoni ... | 1990 | 1972549 |
| the ferret as a model for studying the sexual differentiation of behavioral and reproductive function. | 1990 | 1974798 | |
| evaluation of the anti-influenza virus activities of 1,3,4-thiadiazol-2-ylcyanamide (ly217896) and its sodium salt. | 1,3,4-thiadiazol-2-ylcyanamide (ly217896) and its sodium salt were shown to be effective against influenza a and b viruses in vitro and in the mouse model. in nondividing confluent mdck cells, the 50% inhibitory concentration of ly217896 ranged from 0.37 to 1.19 micrograms/ml against various strains of influenza a virus and from 0.75 to 1.54 micrograms/ml against various strains of influenza b virus, with no apparent cytotoxicity. however, at a concentration of 0.31 microgram/ml, ly217896 inhibi ... | 1990 | 2073106 |
| visual response properties and afferents of nucleus of the optic tract in the ferret. | basic properties of responses to visual stimulation with large moving random dot patterns were studied in ferret nucleus of the optic tract. retinal input to not was assessed by orthodromic electrical stimulation of the optic chiasm and optic nerves. presence of an input from visual cortex was tested by orthodromic electrical stimulation of ipsilateral area 17. all 51 not neurons studied displayed a non-habituating, clearly direction-specific response: discharge rate strongly increased with the ... | 1990 | 2073937 |
| effects of early monocular deprivation on response properties and afferents of nucleus of the optic tract in the ferret. | effects of early monocular deprivation on visual response properties of neurons in the nucleus of the optic tract (not) were studied in six adult ferrets. retinal input to not was investigated by orthodromic electrical stimulation of optic chiasm and optic nerves. electrical stimulation of the ipsilateral primary visual cortex was applied to reveal the presence of a cortical pathway to not. all 75 neurons studied in the not displayed the typical strongly direction-specific response to horizontal ... | 1990 | 2073938 |
| the effects of cocaine on intracellular ca2+ handling and myofilament ca2+ responsiveness of ferret ventricular myocardium. | 1. when ferret right ventricular papillary muscles were stimulated with threshold punctate pulses (0.33 hz; 30 degrees c), cocaine, 10(-5) m, increased peak tension development from 815 +/- 120 to 1125 +/- 180 mg (p less than 0.05) and increased the rate of relaxation from peak tension (time to 80% decline from peak tension decreased from 155 +/- 11 to 144 +/- 11 ms; p less than 0.05). these changes in the twitch were associated with comparable changes in the amplitude and time course of the cal ... | 1990 | 2076484 |
| pulmonary arterial and venous constriction during hypoxia in 3- to 5-wk-old and adult ferrets. | we have determined the sites of hypoxic vasoconstriction in ferret lungs. lungs of five 3- to 5-wk-old and five adult ferrets were isolated and perfused with blood. blood flow was adjusted initially to keep pulmonary arterial pressure at 20 cmh2o and left atrial and airway pressures at 6 and 8 cmh2o, respectively (zone 3). once adjusted, flow was kept constant throughout the experiment. in each lung, pressures were measured in subpleural 20- to 50-microns-diam arterioles and venules with the mic ... | 1990 | 2077015 |
| ontogeny of the sexually dimorphic male nucleus in the preoptic/anterior hypothalamus of ferrets and its manipulation by gonadal steroids. | a sexually dimorphic nucleus exists in the dorsal region of the ferret preoptic/anterior hypothalamic area (poa/ah), and is called the male nucleus of the poa/ah (mn-poa/ah) because it is found only in males. development of the mn-poa/ah was studied in male ferrets, and for comparison a sexually nondimorphic ventral poa/ah nucleus was studied in both sexes. the mn-poa/ah was conspicuous in males as early as embryonic day 37 (e37) of a 41-day gestation, and its volume increased until postnatal da ... | 1990 | 2077101 |
| pulmonary vascular pressure profile in 2-3-week-old, 5-6-week-old and adult ferrets. | we have previously reported age-related differences in the pattern of vascular pressure drop in rabbit lungs (raj et al., pediatric res. 20:1107-1111, 1986). the purpose of this study was to investigate if there were similar age related differences in the ferret lung. to determine the profile of vascular pressures and the longitudinal distribution of vascular resistance in arteries, microvessels and veins, we isolated and blood perfused lungs of 20 ferrets (8 adults greater than 6 months of age; ... | 1990 | 2080320 |
| auditory brainstem of the ferret: early cessation of developmental sensitivity of neurons in the cochlear nucleus to removal of the cochlea. | the role of primary afferent innervation in the maintenance of neurons in the mammalian auditory system was assessed by performing unilateral removals of the cochlea in neonatal and mature ferrets of known birth dates. removals were performed under steroid anesthesia and resulted in the complete destruction of the organ of corti and the loss of at least 80% of type i spiral ganglion neurons. four main age groups [postnatal days (p)5, p24, p90, and p180] were used. additional animals received no ... | 1990 | 2081818 |
| effects of cholecystokinin (cck-8) on two classes of gastroduodenal vagal afferent fibre. | in order to investigate the vagal afferent pathway responsible for the previously reported effects of cholecystokinin (cck) on gastric emptying and food intake, single afferent fibres were recorded from the cervical vagus of urethane-anaesthetized ferrets. sixty tension receptor afferents with receptive fields in the corpus, antrum, duodenum, jejunum and ileum all showed a resting level of discharge which was augmented powerfully by distension of the segment containing the ending. close intraart ... | 1990 | 2084184 |
| ultrastructure of the leptomeninx of the fetal ferret spinal cord and cerebrum. | the ultrastructures of the leptomeninx of the spinal cord and cerebrum was examined in the 32 d post-conception fetal ferret. leptomeningeal cells of the fetal ferret spinal cord have a moderately electron dense cytoplasm and nucleoplasm. the cisternae of endoplasmic reticulum are filled with an amorphous material and are more numerous in cells covering the lateral part of the cord. collagen fibrils are also abundant in this region. glycogen granules are only rarely present and then only in arac ... | 1990 | 2088147 |
| isolation of campylobacter coli from a proliferative intestinal lesion in a ferret. | 1990 | 2094455 | |
| effects of length change on intracellular ca2+ transients in ferret ventricular muscle treated with 2,3-butanedione monoxime (bdm). | quick release of the right ventricular papillary muscle of ferrets, injected with aequorin, from lmax (initial length) to 92% lmax during twitch response produced an extra-light signal of aequorin. 2,3-butanedione monoxime (bdm) at 10 mm decreased the peak tension to less than 10% of that in control and the light signal to 70%. in the bdm-treated muscle, the extra-light in response to the quick release did not occur. a quick stretch from lmax to 103% lmax, in the presence and absence of bdm, did ... | 1990 | 2094785 |
| in vivo findings associated with heat generation during thermomechanical compaction of gutta-percha. 1. temperature levels at the external surface of the root. | temperature elevations of 10 degrees c above body temperature, of duration greater than 1 minute, may be sufficient to cause bone tissue injury. temperature rises on the root surface in excess of 10 degrees c have been shown in studies in vitro of thermoplasticized gutta-percha root filling techniques. to determine whether results in vitro at room temperature could be extrapolated to conditions in vivo, temperature elevations were recorded at the mid-point on the root surface of the canine tooth ... | 1990 | 2098343 |
| in vivo findings associated with heat generation during thermomechanical compaction of gutta-percha. 2. histological response to temperature elevation on the external surface of the root. | an in vivo investigation is described and a histological evaluation made of the effect of canal obturation by thermomechanical compaction of gutta-percha and sealer on the cementum on the lateral surface of the root and adjacent periodontal membrane and alveolar bone of the ferret canine after time intervals of 24 hours, 20 days and 40 days. these tissue reactions were compared with those in the roots of control teeth filled by lateral condensation of cold gutta-percha and sealer. iatrogenic dam ... | 1990 | 2098344 |
| magnesium transport in ferret red cells. | 1. mg2+ efflux from ferret red cells into a nominally mg2(+)-free medium is 41 +/- 2 mumol (l cell)-1 h-1. the properties of mg2+ transport can be measured in these cells without the need for mg2+ loading. 2. amiloride, quinidine, imipramine and external divalent cations partially inhibit mg2+ efflux. maximal inhibition by these agents is about 60-70% suggesting that at least two mg2+ transport pathways exist. 3. as external na+ is replaced by choline or n-methyl-d-glucamine mg2+ efflux is first ... | 1990 | 2100303 |
| submandibular responses to stimulation of the parasympathetic innervation in bursts in the anaesthetized ferret. | 1. submandibular salivary and vascular responses to different patterns of stimulation of the parasympathetic innervation have been investigated in anaesthetized ferrets in the presence and absence of atropine. 2. at low stimulus frequencies likely to fall within the physiological range (0.5-2.0 hz continuously; 5.0-20.0 hz in 1 s bursts at 10 s intervals) secretion of fluid and protein were both potentiated by the bursting pattern of stimulation and the latency of the secretory response was redu ... | 1990 | 2100312 |
| species differences in susceptibility to ischemic injury and responsiveness to myocardial protection. | isolated hearts from rabbits, hamsters, ferrets, gerbils, rats, mice and guinea pigs were used to investigate species differences in (i) stability during aerobic perfusion, (ii) susceptibility to ischemic injury and (iii) responsiveness to cardioplegic protection. during 120 minutes of continuous aerobic perfusion, the rate of functional deterioration differed between species. the rabbit was the most stable and the guinea pig the least: the mean +/- sem of the left ventricular developed pressure ... | 1990 | 2102801 |
| an efficient isolation procedure of ca-tolerant ventricular myocytes from ferret heart for applications in electrophysiological studies. | a simple procedure which provides a large yield of isolated ferret ventricular myocytes is described. the enzymatic dissociation was performed by perfusion of the whole heart with the "langendorff method" at 37 degrees c, without an incubation period. special attention was given to the period of perfusion with ca-free or low-calcium containing solutions and to the proportion of both collagenase and elastase used. the viability and calcium tolerance of the isolated cells were tested by ultrastruc ... | 1990 | 2103519 |
| control of ph of airway surface liquid of the ferret trachea in vitro. | we measured the ph of airway surface liquid (asl) secreted by the ferret trachea in vitro by using a catheter-tipped ph electrode implanted in a collecting cannula close to the airway epithelium. mucus secretion was promoted by methacholine (0.02 mmol/l) in the organ bath. the ph of the asl was 6.85 +/- 0.03 (se) compared with a bath value of 7.39 +/- 0.01, when the bath was bubbled with 5.65% co2. changing the bath co2 from 0 to 20.93% co2 altered the bath ph from 8.06 to 6.96, but the asl ph o ... | 1990 | 2107164 |
| quantification of [ca2+]i in perfused hearts. critical evaluation of the 5f-bapta and nuclear magnetic resonance method as applied to the study of ischemia and reperfusion. | calcium has been implicated as a mediator of cell injury in ischemia and reperfusion, but direct measurements of ca2+ are required to refine this idea. we used nuclear magnetic resonance spectroscopy and the ca2+ indicator 5f-bapta to measure [ca2+]i in perfused ferret hearts. several lines of evidence are presented to show that loading with the acetoxymethyl ester of 5f-bapta is not significantly complicated by accumulation of partially de-esterified metabolites, compartmentalization into mitoc ... | 1990 | 2110515 |
| a comparative biochemical and ultrastructural study of proteoglycan-collagen interactions in corneal stroma. functional and metabolic implications. | 1. corneas of mouse, rat, guinea pig, rabbit, sheep, cat, dog, pig and cow were quantitatively analysed for water, hydroxyproline, nucleic acid, total sulphated polyanion, chondroitin sulphate/dermatan sulphate and keratan sulphate, several samples or pools of tissue from each species being used. ferret cornea was similarly analysed for water and hydroxyproline on one pool of eight corneas. pooled frog (38) and ferret (eight) corneas and a single sample of human cornea were qualitatively examine ... | 1990 | 2119175 |
| large and small airway responses to bronchoconstrictors in the guinea pig and ferret. | in the isolated, perfused lung lobe of the ferret we evaluated the bronchoconstrictor response of its airways to methacholine and histamine, pharmacologic agents associated with the asthmatic state. the bronchus of excised lobes was cannulated and needle scarifications were made on the pleural surface to allow perfusate to exit. lung airways were perfused at constant flow with equilibrated 95% o2/5% co2, warmed krebs-ringers solution. perfusion pressure was measured as a gauge of airway resistan ... | 1990 | 2126832 |
| epithelium-derived pge2 inhibits the contractile response to cholinergic stimulation in isolated ferret trachea. | we have previously reported that epithelium-dependent inhibitory factors, both prostanoids and non-prostanoids, can be activated by electrical field stimulation (efs) and direct nerve stimulation (dns) in an in vitro nerve-muscle preparation of ferret trachea. in this study we set out to compare the release of the inhibitory prostanoids, pge2 and pgi2, in preparations with intact and with removed epithelium. ferret tracheae were mounted in organ baths and phasic contractions were induced by efs ... | 1990 | 2135219 |
| dexamethasone can potentiate the anti-emetic action of a 5ht3 receptor antagonist on cyclophosphamide induced vomiting in the ferret. | a new group of selective 5ht3 antagonists are proving to be effective anti-emetics for cytotoxic and radiation induced vomiting in both animal models and man. current anti-emetic regimens often benefit from combination therapy, in particular the efficacy of metoclopramide (which can be a weak 5ht3 antagonist), can be improved by combination with dexamethasone, another anti-emetic. hence it was of interest to evaluate whether a 5ht3 receptor antagonist gr38032f could be improved by combination wi ... | 1990 | 2137008 |
| dracunculus insignis in ferrets: comparison of inoculation routes. | three routes of inoculation were compared to determine the best method to infect ferrets with dracunculus insignis. the traditional method of administering infected cyclops containing l3s through gavage was compared to intraperitoneal (i.p.) and subcutaneous (s.c.) inoculation of l3s. ten of 18 (56%) gavaged ferrets became infected after receiving copepods containing approximately 100 l3s each; 44 adult worms were recovered from these 10 animals. twenty-one of 28 (75%) animals inoculated with 50 ... | 1990 | 2137166 |
| a 36 nucleotide deletion mutation in the coding region of the ns1 gene of an influenza a virus rna segment 8 specifies a temperature-dependent host range phenotype. | previously a spontaneous 36 nucleotide deletion in the coding region of ns1 was detected in the ns gene of a reassortant virus (cr43-3) recovered from a dual infection by the influenza a/ann arbor/6/60 cold-adapted (ca) mutant and wild-type (wt) influenza a/alaska/6/77 (h3n2). the hemagglutinin, neuraminidase and ns genes were derived from the wild type virus parent while the other 5 genes were derived from the ca parent. the cr43-3 reassortant virus exhibited: (i) a host range (hr) phenotype, i ... | 1990 | 2138396 |
| cell calcium, oncogenes, and hypertrophy. | the cellular mechanisms of cardiac hypertrophy remain unclear despite tantalizing clues gleaned from a variety of experimental approaches. here we examine the hypothesis that an increase in cytosolic free ca2+ concentration ([ca2+]i) triggers the expression of proto-oncogenes, which in turn direct the characteristic increase in protein synthesis. new results from perfused ferret hearts are presented demonstrating that [ca2+]i increases as a direct consequence of an elevation in perfusion pressur ... | 1990 | 2140817 |
| distribution, behavior, and course of patency of dracunculus insignis in experimentally infected ferrets. | from 106 ferrets experimentally infected with dracunculus insignis, 273 female worms and 42 male worms were recovered. the percentage of female worms that mated, the location of all worms, and the rate of emergence of gravid females were recorded. of 174 mature female worms recovered, only 11% had emerged before necropsy. eighty-one percent of the male worms and 87% of all unmated (immature) females were found on the trunk of the animal or on the skin overlying it. gravid female worms were found ... | 1990 | 2143224 |
| chemoprophylactic drug trials for treatment of dracunculiasis using the dracunculus insignis-ferret model. | groups of ferrets inoculated with dracunculus insignis were treated with various anthelminthic compounds to evaluate the potential use of drugs in controlling the human parasite d. medinensis. the three primary compounds tested were diethylcarbamazine (dec), albendazole (albz), and invermectin (iver); they were administered in dosages of 60 mg/kg, 10 mg/kg, and 1 mg/kg, respectively. groups of animals received treatment either once at 60 days after inoculation, once at 60 and 90 days, or for 3 d ... | 1990 | 2143770 |
| distribution of growth-associated protein, b-50 (gap-43) in the mammalian enteric nervous system. | the presence of the growth-associated protein, b-50 (also known as gap-43) was investigated in the adult mammalian enteric nervous system. the small intestine of rat, ferret and human was examined by immunohistochemistry. dense b-50-like immunoreactivity was localized in nerves throughout the wall of the rat, ferret and human small intestine, notably in the myenteric and submucous plexuses, where in the ferret ileum it co-localized with vasoactive intestinal polypeptide-immunoreactive fibre grou ... | 1990 | 2147742 |
| differential effects of caffeine on skinned fibers from control and hypertrophied ferret hearts. | the effects of caffeine on the mechanical properties of detergent-skinned fibers from control and pressure-overloaded ferret hearts have been compared. right ventricle hypertrophy was studied 6 wk after pulmonary artery ligation, an intervention that increased the right ventricular weight-body weight ratio by 60%. although no changes were observed in the ca sensitivity of contraction between control [pca for one-half-maximal activation (pca50) = 5.80 +/- 0.05] and hypertrophied (pca50 = 5.85 +/- ... | 1990 | 2148060 |
| intracellular calcium related to force development in twitch contraction of mammalian myocardium. | to characterize the relationship between force production and ca2+ occupancy of troponin c, investigators have related peak intracellular ca2+, measured with a variety of ca2(+)-indicators, and peak force during twitches. inherent in the force-[ca2+] relationship is the responsiveness of the myofilaments to ca2+ which can be altered by different pharmacological manipulations. in this study we compared the force-[ca2+] relationship obtained in aequorin-injected papillary muscles and saponin skinn ... | 1990 | 2148283 |
| nerve growth factor receptor immunoreactivity is transiently associated with the subplate neurons of the mammalian cerebral cortex. | nerve growth factor and its receptor (ngfr) are known to be present in diverse embryonic and neonatal central nervous system tissues, including the cerebral cortex. however, the identity of the cortical cells expressing ngfr immunoreactivity has not been established. we have used immunolabeling coupled with [3h]thymidine autoradiography to identify such cells in ferret and cat brain. polyclonal antibodies raised against a synthetic peptide corresponding to a conserved amino acid sequence of the ... | 1990 | 2153287 |
| phase i/ii trial of granisetron: a novel 5-hydroxytryptamine antagonist for the prevention of chemotherapy-induced nausea and vomiting. | a new class of antiemetic agents, the 5-hydroxytryptamine (5-ht3) antagonists, have been shown to possess potent antiemetic properties in the ferret model. we conducted a phase i/ii trial of the 5-ht3 antagonist brl43694 (granisetron) in 24 chemotherapy-naïve patients who were receiving any combination of doxorubicin and/or cisplatin. the first 12 patients received 40 micrograms/kg and the second 12 received 80 micrograms/kg of granisetron intravenously before beginning chemotherapy. nausea was ... | 1990 | 2153767 |
| derivation of gnotobiotic ferrets: perinatal diet and hand-rearing requirements. | a procedure is described which has resulted in successful gnotobiotic derivation of the domestic ferret. the most critical element of this hand-rearing procedure was found to be diet, with ferret milk being required for at least the first 7 days. puppy milk replacer was phased in during the next 10 days, and enriched cow's milk sufficed thereafter. around-the-clock sip-feeding with fire-polished pasteur pipettes was necessary at intervals gradually increasing from 1 to 1.5 hours at birth to 3 ho ... | 1990 | 2153861 |
| thyroid and adrenal function tests in adult male ferrets. | effects of thyroid-stimulating hormone (tsh) and thyrotropin-releasing hormone (trh) on plasma concentrations of thyroid hormones, and effects of acth and dexamethasone on plasma concentrations of cortisol, were studied in adult male ferrets. thirteen ferrets were randomly assigned to test or control groups of eight and five animals, respectively. combined (test + control groups) mean basal plasma thyroxine (t4) values were different between the trh (1.81 +/- 0.41 micrograms/dl, mean +/- sd) and ... | 1990 | 2154147 |
| the role of mitochondria and sarcoplasmic reticulum calcium handling upon reoxygenation of hypoxic myocardium. | the mechanism of twitch prolongation of hypoxic myocardium after reoxygenation was studied before and after interventions that affect cellular cyclic nucleotide levels, subcellular calcium handling, or oxygen-derived free radical production/survival. right ventricular ferret papillary muscles were subjected to two 20-minute periods of hypoxia, each followed by 1 hour of reoxygenation. the first sequence of hypoxia/reoxygenation was done without intervention. before the second sequence, the pharm ... | 1990 | 2155067 |
| reduction of calculus accumulation in domestic ferrets with two dentifrices containing pyrophosphate. | work performed by king et al. in the 1940's and 1950's, as well as recent studies by our group, have shown that the domestic ferret is a suitable model for the study of calculus formation, offering several advantages over the rodent and dog models in current use. we have demonstrated that mineral supplementation of a moist diet accelerates calculus accumulation, and that twice-daily application of a regular dentifrice slows the initial rate of calculus formation, but permits significant accumula ... | 1990 | 2155258 |
| aleutian disease parvovirus infection of mink and ferrets elicits an antibody response to a second nonstructural viral protein. | a second nonstructural protein of the aleutian disease parvovirus was predicted from nucleotide sequence analysis and a detailed transcription map. western immunoblotting analysis showed that infected mink and ferrets show an antibody response to this predicted protein. | 1990 | 2157070 |
| effects of yohimbine on bradycardia and duration of recumbency in ketamine/xylazine anesthetized ferrets. | eleven adult ferrets (mustela putorius furo) were anesthetized with ketamine hydrochloride (25 mg/kg, im) and xylazine hydrochloride (2 mg/kg, im). fifteen minutes post-ketamine/xylazine injection, ferrets were treated with yohimbine hydrochloride at a dose of 0.5 mg/kg, or an equal volume of physiologic saline, intramuscularly. each ferret served as its own control by randomly receiving both treatments with a minimum interval of 2 weeks between treatments on any one ferret. at 15 minutes post-k ... | 1990 | 2157099 |
| growth of the ferret tracheobronchial tree. | because the ferret is being used increasingly in inhalation toxicology and lung physiology studies, it is necessary to better understand the airway structure of its tracheobronchial tree. previously published information does not include dimensions of bronchi and bronchioles in either adult or growing ferrets. the airway structure of interest for calculating inhaled particle deposition patterns includes airway lengths, diameters and branching angles in each generation. measurements of these dime ... | 1990 | 2157101 |
| leiomyosarcoma in a domestic ferret: morphologic and immunocytochemical diagnosis. | 1990 | 2157107 | |
| emesis and defecations induced by the 5-hydroxytryptamine (5-ht3) receptor antagonist zacopride in the ferret. | three antiemetic compounds (zacopride, batanopride, granisetron [brl43694]) were evaluated for the production of gastrointestinal side effects in the conscious ferret after i.v. or p.o. administration. zacopride evoked multiple emetic and defecatory responses at clinically relevant doses (0.003-0.3 mg/kg) and in a dose-dependent manner. the oral route was the more potent one for eliciting emesis (ed50 0.033 mg/kg). at 0.3 mg/kg p.o., zacopride reliably evoked an 80 to 100% incidence of emesis an ... | 1990 | 2162943 |
| rg 12915: a potent 5-hydroxytryptamine-3 antagonist that is an orally effective inhibitor of cytotoxic drug-induced emesis in the ferret and dog. | rg 12915 [4-[n-(1-azabicyclo[2.2.2.]octan-3-(s)-yl)]2-chloro-cis 5a-(s)-9a-(s)-5a,6,7,8,9,9a-hexahydrobenzofurancarboxamide hydrochloride] is a potent and effective agent against cisplatin-induced emesis in the ferret after i.v. or p.o. administration. this agent (p.o.) is also highly protective against cisplatin-induced emesis in the dog, as well as cyclophosphamide/doxorubicin-induced emesis in the ferret. when administered either p.o. or i.v., rg 12915 has a lower ed50 value (0.004 mg/kg) tha ... | 1990 | 2166791 |
| recovery of contractility and phi during respiratory acidosis in ferret hearts: role of na(+)-h+ exchange. | during acute respiratory acidosis, cardiac contractile pressure first drops but then recovers substantially. we investigated the mechanism of this response in isovolumic perfused ferret hearts. developed pressure (dp) and its first derivative (dp/dt) were measured before, during, and after hypercapnia induced by equilibrating the perfusate with 15% co2, rather than the 5% co2 used in control. intramyocardial ph (phi) was measured by phosphorus nuclear magnetic resonance (nmr) spectroscopy. after ... | 1990 | 2168681 |
| the role of specific 5-ht3 receptor antagonism in the control of cytostatic drug-induced emesis. | work on the pharmacological effects of high-dose metoclopramide led beecham scientists to identify the role of 5-ht3 receptors in the emetic response to cytostatic drugs and x-irradiation in animals. further studies have confirmed and extended knowledge of the novel 5-ht3 antagonist granisetron. dose-dependent inhibition of the 5-ht-induced bezold-jarisch reflex in anaesthetized rats was shown by doses of 0.1-10 micrograms/kg i.v. granisetron. radioligand binding studies in rat brain revealed a ... | 1990 | 2169786 |
| transitional cell carcinoma of the renal pelvis in a ferret. | 1990 | 2170760 | |
| effect of temperature on the rise in intracellular sodium caused by calcium depletion in ferret ventricular muscle and the mechanism of the alleviation of the calcium paradox by hypothermia. | the effects of temperature over the range 37-10 degrees c on the responses of isolated ferret ventricular trabeculae to the depletion and repletion of bathing calcium has been investigated. cooling is found to reduce the rate of rise of intracellular sodium activity (measured with an ion-sensitive microelectrode) induced by depletion of bathing divalent cations, without affecting the prolonged depolarization. the rate of rise of [na]i (with the sodium pump inhibited) shows a dependence on temper ... | 1990 | 2171805 |
| melatonin receptors are present in the ferret pars tuberalis and pars distalis, but not in brain. | the pineal hormone melatonin regulates reproductive function in seasonally breeding mammals. recent studies using 125i-labeled 2-iodomelatonin (i-mel) reveal that the distribution of putative melatonin receptors is species-specific; only the hypophysial pars tuberalis (pt) is a consistent site of i-mel binding in all photoperiodic species examined. in the present study, we used in vitro autoradiography to examine the distribution of i-mel binding in the ferret brain and pituitary. we report that ... | 1990 | 2171920 |
| a technique for femoral bone marrow collection in the ferret. | 1990 | 2172640 | |
| an elisa for detection of antibodies against influenza a nucleoprotein in humans and various animal species. | a double antibody sandwich blocking elisa, using a monoclonal antibody (mab) against influenza a nucleoprotein (np) was developed to detect antibodies against influenza. collections of serum samples were obtained from human and various animal species. all influenza a subtypes induced antibodies against hemagglutinins and np. a close correlation between titers of the hemagglutination inhibition (hi) test and the np-elisa was seen. antibodies against influenza np were demonstrated in serum samples ... | 1990 | 2174233 |
| evidence for presynaptic 5-hydroxytryptamine3 recognition sites on vagal afferent terminals in the brainstem of the ferret. | antagonists acting at the 5-hydroxytryptamine3 receptor are potent anti-emetic agents in cases of cytotoxic- and radiation-induced vomiting, and binding sites for these compounds have been described in brainstem areas known to be involved in mediation of nausea and vomiting. we have used autoradiography to examine the distribution of one of these antagonists, [3h]granisetron in the caudal brainstem of the ferret, a commonly used animal model for physiological investigations of emesis. the highes ... | 1990 | 2176720 |
| bradykinin and respiratory mucous membranes. analysis of bradykinin binding site distribution and secretory responses in vitro and in vivo. | bradykinin (bk) and lysyl-bk (lys-bk, kallidin) have been proposed as potentially important mediators of rhinorrhea. possible mechanisms by which bk might contribute to rhinorrhea were investigated by several approaches. (1) the autoradiographic distribution of 125i-bk binding sites in human inferior turbinate nasal mucosa was determined. (2) the effects of bk and lys-bk and antagonists on radiolabeled respiratory glycoconjugate (rgc) release from human nasal mucosa was measured. (3) the secreto ... | 1990 | 2178531 |
| animal models in the study of vomiting. | the emetic responses to various pharmacological agents, cytotoxins, and radiation are compared among animal species. the species included for comparison are the human, nonhuman primate, dog, cat, and ferret. the categories of pharmacologic compounds include both those compounds that act on identified membrane receptors (e.g., cholinergic agonists, catecholamines, and neuroactive peptides) and those that act on unidentified receptors (e.g., cardiac glycosides and veratrum alkaloids, among others) ... | 1990 | 2178751 |
| the abdominal visceral innervation and the emetic reflex: pathways, pharmacology, and plasticity. | in recent years the role of the area postrema in the emetic reflex has been predominant and the involvement of the abdominal visceral innervation has tended to be overlooked. this paper attempts to redress the balance reflex by reviewing aspects of the existing literature and complementing this with original studies from the ferret. in view of the widespread use of the ferret in studies of emesis and particularly in the characterization of the antiemetic actions of 5-ht3 receptor antagonist, the ... | 1990 | 2178756 |
| electromechanical effects of endothelin on ferret bronchial and tracheal smooth muscle. | the effects of endothelin (et) on transmembrane potential and isometric force were studied in ferret bronchial and tracheal smooth muscles. at rest, the muscle cells were electrically and mechanically quiescent. the mean resting potential for the bronchial cells was -70 +/- 1 mv (n = 25 cells/8 ferrets), and that of the tracheal cells was -60 +/- 1 mv (n = 7 cells/2 ferrets). et depolarized and contracted both types of muscle cells in a concentration-dependent manner. at 1 nm et, the bronchial m ... | 1990 | 2179208 |
| toxicology of selected pesticides, drugs, and chemicals. zinc. | zinc poisoning in small animals has been described in dogs, cats, birds, and ferrets, but the dog appears to be the species most often affected. ingestion of zinc-containing metallic objects, including pennies, and zinc oxide ointments has been associated with the majority of the toxicoses. clinical signs include anorexia, vomiting, diarrhea, hemolytic anemia, kidney dysfunction, and possible liver and pancreatic abnormalities. treatments that have proven efficacious include fluid diuresis, bloo ... | 1990 | 2180195 |
| differential interaction of virulent and attenuated influenza virus strains with ferret alveolar macrophages: possible role in pathogenicity. | the ferret provides a unique model for the study of human influenza. the interaction between alveolar macrophages and virus strains with different levels of virulence was examined in vitro. the greater virulence of wild-type a strains over type b and c viruses was reflected in the higher production of infectious virus progeny and subsequent cytopathology, even though the expression of viral antigens was equivalent for all strains tested. these included a/ann arbor/6/60 (h2n2) and a/rochester/1/8 ... | 1990 | 2181032 |
| electromechanical effects of endothelin in ferret bronchial and tracheal smooth muscle. | 1990 | 2181482 | |
| the inhibitory effect of halothane on the emetic response in the ferret. | emesis and nausea are often associated with anaesthesia and continue to be a common clinical problem. past clinical studies have demonstrated that halothane produces a higher incidence of vomiting compared with other anaesthetics, but some investigators have described an antiemetic effect. the purpose of this study was to investigate the effects of various doses of halothane on the emetic response in the decerebrate ferret. following a control emetic response, a maximum of six increasing cumulat ... | 1990 | 2182187 |
| abnormal intracellular calcium handling in acute and chronic heart failure: role in systolic and diastolic dysfunction. | acute or chronic heart failure may be caused by one or more of a variety of abnormalities including changes in excitation-contraction coupling processes (i.e. decreased availability of activator ca2+ or a change in myofilament ca2+ responsiveness), a change in myocardial energetics, or a change in extracellular factors, such as connective tissue content. most of the animal and human models of acute cardiac failure that we have studied in our laboratory (i.e. negative inotropic responses to drugs ... | 1990 | 2188844 |
| enterocecocolitis associated with intraepithelial campylobacter-like bacteria in rabbits (oryctolagus cuniculus). | we examined 28 suckling, weanling, and young adult rabbits with lethargy, inappetence, and mucinous, semifluid feces. sixteen of the rabbits had intestinal lesions. in eight of these rabbits, the primary changes were multifocal to diffuse epithelial proliferation and accumulation of lymphocytes, macrophages, or both in the lamina propria of the small intestine, cecum, and sacculated colon. in two of these rabbits, the accumulation of macrophages in the lamina propria was extensive. the other eig ... | 1990 | 2189255 |
| pituitary responsiveness to luteinizing hormone-releasing hormone in prepubertal and postpubertal male ferrets. | the pituitary response to three different doses of exogenously administered lhrh was examined in prepubertal (9-wk-old) and postpubertal (32-wk-old) male ferrets. the doses of 5, 10, and 15 ng lhrh/kg body weight tested in this study produced dose-related increases in circulating lh concentrations in both pre- and postpubertal groups. in addition, a significant effect of age on lh response was observed, with the prepubertal animals demonstrating significantly greater serum lh values in response ... | 1990 | 2198953 |
| endocrine pathology of estrogens: species differences. | the clinical uses of estrogens are associated with serious adverse effects, so the experimental toxicology of these compounds is under continuous review. structurally different estrogens have qualitatively similar effects in animals when given in amounts way above the rodent uterotrophic dose. toxicity still tends, however, to be related to estrogenic potency. carnivores are more susceptible than rodents. changes in reproductive, mammary and endocrine tissues are consistent with hyperestrogenism ... | 1990 | 2203070 |
| hepatic steatosis during convalescence from influenza b infection in ferrets with postprandial hyperinsulinemia. | the possibility that postprandial hyperinsulinemia could play a role in the development of hepatic lipid disturbances during convalescence from influenza b infection was explored in the ferret as a possible model of the steatosis of reye's syndrome. postprandial hyperinsulinemia was produced by feeding young ferrets glucose/water and a regular diet (glucose-treated group), as reflected by the mean serum insulin levels attained, which were 57 and 135 microu/ml during control and postinfluenza per ... | 1990 | 2205696 |
| performance of a tv image analysis system as a microdensitometer. | the performance of a tv image analysis system combined with an automated microscope (the leitz tas plus) as a microdensitometer and morphometric device was investigated. there was a strict linear correlation (r greater than .99) between the physically defined optical transmission values and the resulting electronic signals from the plumbicon tv camera for the whole area displayed on the monitor. the shading of the optoelectronic system had a coefficient of variation (cv) of 1.42% for measurement ... | 1990 | 2206196 |
| medullary sites mediating some abdominal vagal reflexes in the ferret using [14c]2-deoxyglucose. | the central projections of some abdominal visceral afferents passing through the vagal communicating branch were studied in anesthetized ferrets using [14c]2-deoxyglucose autoradiography. the reflex effects of electrical stimulation of the vagal communicating branch were studied while measurements of jejunal motor activity and transmural potential difference, a marker of electrogenic epithelial transport were made concurrently. the aim of this study was to examine brainstem projections of some a ... | 1990 | 2207629 |
| in vivo morphogenetic activity of dentine matrix proteins. | matrix proteins (edta-soluble and collagenase-released) from rabbit dentine have been demonstrated to show in vivo morphogenetic activity in exposed pulps of ferret canine teeth. in young adult ferrets, the reparative dentine resembled normal primary tubular dentine with odontoblast-like cells lining its formative surface. the reparative response in older animals was seen as osteo-dentine deposition. in both cases, the reparative response was characterized by its intensity within a comparatively ... | 1990 | 2211578 |
| immunological detection of cat uterine proteins in ferrets, dogs and baboons. | in the cat, a high molecular weight (greater than 320 kda) estrogen (e2)-dependent protein (cuped) and a group of low molecular weight (28 kda, 36 kda, 41 kda) progesterone (p)-dependent proteins (pdp) are synthesized by the epithelial cells of the deep uterine glands and secreted into the lumen. the present study was designed to investigate the possibility that other species synthesize proteins similar to cuped and pdp in response to steroids. uterine flushings and media from cultured endometri ... | 1990 | 2213724 |
| effects of lesions of a sexually dimorphic nucleus in the preoptic/anterior hypothalamic area on the expression of androgen- and estrogen-dependent sexual behaviors in male ferrets. | the male nucleus of the preoptic/anterior hypothalamic area (mn-poa/ah) is a sexually dimorphic structure present in male, but not in female ferrets. ovariectomized female ferrets given increasing dosages of estradiol benzoate (eb) normally run faster towards a stud male in an l-maze (i.e. become more proceptive). in two separate experiments, only gonadectomized males with bilateral damage to the mn-poa/ah following large or small electrolytic lesions approached stud males more quickly in respon ... | 1990 | 2224522 |
| the innervation of tracheal smooth muscle in the ferret. | the innervation of tracheal smooth muscle in the ferret has been studied by monitoring pressure changes in a fluid-filled segment of trachea in pentobarbitone anaesthetized animals. stimulation of the peripheral cut end of the vago-sympathetic trunk elicited increases in trachea segment pressure only when activity was evoked in non-myelinated efferent axons, myelinated axons were without effect. such excitatory responses were blocked by atropine. after atropine and elevation of trachealis muscle ... | 1990 | 2229889 |
| peptidergic innervation of the major salivary glands of the ferret. | in parotid, sublingual and submandibular glands of the ferret, morphological correlates were looked for, using immunocytochemistry, to previous physiological findings showing parasympathetic "atropine-resistant" salivary secretion and neuropeptide-evoked salivation in this species. nerve fibers storing vip were numerous in association with acini, ducts and blood vessels, while the number of fibers storing substance p was moderate and those containing cgrp and galanin few; also the number of npy- ... | 1990 | 2235685 |
| molecular characterization of a new hemagglutinin, subtype h14, of influenza a virus. | two influenza a viruses whose hemagglutinin (ha) did not react with any of the reference antisera for the 13 recognized ha subtypes were isolated from mallard ducks in the ussr. antigenic analysis by hemagglutination inhibition and double immunodiffusion tests showed that the has of these viruses are similar to each other but distinct from the has of other influenza a viruses. nucleotide sequence analysis showed that these ha genes differ from each other by only 21 nucleotides. however, they dif ... | 1990 | 2238469 |
| the effect of surgical anaesthesia on antral motility in the ferret. | gastric motility was recorded from ferrets chronically prepared with an antral strain gauge. in fasted animals, antral motility showed cycles of activity and quiescence typical of the migrating motor complex (mmc) with a period of 44.7 +/- 6.1 min (n = 4). anaesthesia with pentobarbitone sodium (50 mg/kg) disrupted this interdigestive motor pattern which returned along with recovery from anaesthesia. the first cycle of antral motility occurred 119 +/- 23.9 min after the onset of anaesthesia and ... | 1990 | 2245020 |
| regulation of force in skinned, single cells of ferret aortic smooth muscle. | an isolation technique was developed for single cells from the ferret aorta, which resulted in the isolation of long (87 +/- 27 microns; x +/- sd, n = 62), relaxed, pharmacologically active smooth muscle cells. these cells were attached to microtools, one of which was connected to a force transducer. force in maximally phenylephrine-stimulated contractions of the intact cells averaged 2.3 +/- 1.4 micron (n = 17). after cell skinning with saponin, the threshold for force development was 0.05 micr ... | 1990 | 2247345 |
| reproductive failure in mink and ferrets after intravenous or oral inoculation of campylobacter jejuni. | four pregnant mink and seven pregnant ferrets, including five with previous exposure and specific antibody, were injected intravenously with 10(8)-10(10) colony-forming units of campylobacter jejuni. all 11 pregnancies failed 1-16 days after infection, with results ranging from fetal resorption to expulsion of dead or premature living kits. in every case, uterine contents (placenta, uterine fluid and/or kits) were culture-positive for c. jejuni. three pregnant mink and nine pregnant ferrets, inc ... | 1990 | 2249178 |
| 23na-nmr measurements of intracellular sodium in intact perfused ferret hearts during ischemia and reperfusion. | 23na nuclear magnetic resonance (nmr) spectroscopy was utilized to measure intracellular na+ in perfused ferret hearts exposed to the shift reagent dysprosium triethylenetramine-hexa-acetic acid [dy(ttha)3-]. the intracellular na+ signal was small under normal perfusion conditions; resolution was enhanced by using a jump-return nmr pulse protocol. during 20 min of total global ischemia at 30 degrees c, intracellular na+ concentration ([na+]i) increased steadily to a peak value fivefold greater t ... | 1990 | 2260701 |
| neutron spectrum measurements in the aluminum oxide filtered beam facility at the brookhaven medical research reactor. | neutron spectrum measurements were performed on the aluminum oxide filter installed in the brookhaven medical research reactor (bmrr). for these measurements, activation foils were irradiated at the exit port of the beam facility. a technique based on dominant resonances in selected activation reactions was used to measure the epithermal neutron spectrum. the fast and intermediate-energy ranges of the neutron spectrum were measured by threshold reactions and 10b-shielded 235u fission reactions. ... | 1990 | 2268243 |
| the auditory periphery of the ferret. i: directional response properties and the pattern of interaural level differences. | the transformations of sound by the auditory periphery of the ferret have been investigated using an impulse response technique for a large number of sound locations surrounding the animal. individual frequencies were extracted from the detailed spectral transformation functions (stfs) obtained for each stimulus location and, using sophisticated spatial interpolation routines, were used to calculate the directional response of the periphery at that frequency. the strength of the directional resp ... | 1990 | 2269734 |
| the auditory periphery of the ferret. ii: the spectral transformations of the external ear and their implications for sound localization. | in the previous paper the directional response characteristics of the ferret auditory periphery were examined. in this study further measurements of the spectral transfer functions (stfs) of the auditory periphery were obtained at locations close to the tympanic membrane. there was considerable variation in the stfs recorded from different animals and between recordings made at each end of the auditory canal in the same animal. however, calculation of the so called "location dependency function" ... | 1990 | 2269735 |
| intracellular free magnesium and its regulation, studied in isolated ferret ventricular muscle with ion-selective microelectrodes. | intracellular free magnesium ([mg2+]i) was measured in isolated ferret papillary muscles using ion-selective microelectrodes filled with the new magnesium sensor eth 5214. this new sensor, unlike its predecessor eth 1117, does not react to marked changes in k+, na+ or ph. reducing ca2+ from 20 microm to around 10 nm also did not affect the response so these electrodes are ideally suited to study intracellular mg2+ and its regulation. the mean value for the [mg2+]i from thirty-two experiments (fo ... | 1990 | 2271154 |
| adaptation of the mechanisms controlling gastric motility following chronic vagotomy in the ferret. | changes in gastric motility were studied in the urethane-anaesthetized ferret following acute or chronic (3 weeks) vagotomy. the stomach was divided into the corpus and antrum and the effects of vagotomy on tone, frequency and contraction amplitude were investigated separately in the two gastric regions. in the corpus tone is kept at low levels by vagal activation of nonadrenergic, non-cholinergic (nanc) inhibitory neurones and also tonic sympathetic inhibition of intramural cholinergic activity ... | 1990 | 2271159 |
| flow-volume characteristics in the pulmonary circulation. | isolated ferret and canine lungs were used to validate a method for assessing determinants of vascular volume in the pulmonary circulation. with left atrial pressure (pla) constant at 5 mmhg, flow (q) was raised in steps over a physiological range. changes in vascular volume (delta v) with each increment in q were determined as the opposite of changes in perfusion system reservoir weight or from the increase in lung weight. at each level of q, the pulmonary arterial and left atrial cannulas were ... | 1990 | 2272968 |
| force production following transient potential changes in voltage-clamped myocardium. | inter-relationships between force, membrane voltage and currents were studied in ferret and guinea-pig papillary muscles using the single sucrose gap technique (37 degrees c). the preparations were held at -90 or -40 mv and depolarized (excited) to 0 mv for 180 ms at 1.0 hz. at regular intervals the shape of a single clamp pulse (called '1') was varied and its effects were investigated during the same test cycle and in two subsequent test cycles ('2' and '3'). peak force of contraction 1 (f1) in ... | 1990 | 2275406 |
| the visual pathways of eutherian mammals and marsupials develop according to a common timetable. | data from cats, ferrets, hamsters, macaques, mice, rabbits and rats concerning the time of occurrence of 26 developmental events involved in the establishment of the retinofugal, geniculocortical, corticogeniculate and corticocollicular pathways were analysed. for each species the timing of developmental events was expressed as a proportion of the period between conception and eye opening ('caecal period'). for 6 of these events, the values for all species fell within a range of 1-5% of the caec ... | 1990 | 2279233 |
| bile reflux and the gastric mucosa: an experimental ferret model. | to study the effects of chronic bile reflux on the mammalian gastric mucosa, the ferret model was chosen for its practical aptitude and for its similarity to human gastric anatomy and physiology. a technique was first perfected for endoscopically directed gastric mucosal biopsy in the ferret. subsequently, a surgical model of maximal enterogastric reflux (mr) and a control model of minimal reflux or "nonreflux" (nr) were developed. a stable population of 9 mr and 9 nr ferrets surviving 1-3 years ... | 1990 | 2285676 |
| ultrastructural study of tracer permeability through the cat and ferret enamel organ. | the access of exogenous materials to the developing enamel surface has been intensively studied in rodents, but not in other mammalian species. this ultrastructural study investigates the permeability of injected horseradish peroxidase (hrp) and lanthanum tracers in cat and ferret tooth buds. in cat enamel organs fixed by immersion, lanthanum did not escape the capillaries overlying secretory stage tooth buds, but it did permeate up to the distal junctions of ruffle-ended (ra) and the proximal j ... | 1990 | 2288004 |
| kinetics of deoxyglucose (dg) and fluorodeoxyglucose (fdg) metabolism in rat and ferret brain. | 1990 | 2298832 |