Publications

the canary is alive and singing: birds continue to provide invaluable information about our changing environment.		2011	21184578
[evidence-based acute and long-lasting effects of climatotherapy in moderate altitudes and on the seaside].	evidence has been provided for acute and long-lasting effects of climatotherapeutic rehabilitation of atopic diseases (neurodermatitis, asthma bronchiale) in moderate altitudes. however, to sustain the climatotherapeutical evidence of psoriasis and non-allergic asthma treatment, controlled studies are required, especially for long-lasting benefits. for other indications of climatotherapy in moderate altitudes (heart and circulatory diseases, osteoporosis, metabolic syndrome) the results demonstr ...	2011	21246469
deciphering the role of is6110 in a highly transmissible mycobacterium tuberculosis beijing strain, gc1237.	the capacity of infection and the ability of mycobacterium tuberculosis strains belonging to the beijing family to spread rapidly probably result from genetic advantages and unidentified mechanisms of virulence not yet thoroughly investigated. among the mechanisms proposed to be responsible for the varying virulence phenotypes of m. tuberculosis strains we find is6110 insertions, genetic reorganizations and deletions, which have strong influences on fitness. beijing family is one of the lineages ...	2011	21256084
partial recessive ifn-?r1 deficiency: genetic, immunological and clinical features of 14 patients from 11 kindreds.	we report a series of 14 patients from 11 kindreds with recessive partial (rp)-interferon (ifn)-?r1 deficiency. the i87t mutation was found in nine homozygous patients from chile, portugal and poland, and the v63g mutation was found in five homozygous patients from the canary islands. founder effects accounted for the recurrence of both mutations. the most recent common ancestors of the patients with the i87t and v63g mutations probably lived 1600 (875-2950) and 500 (200-1275) years ago, respect ...	2011	21266457
sun exposure induces rapid immunological changes in skin and peripheral blood in patients with psoriasis.	ultraviolet (uv) radiation has immunosuppressive effects and heliotherapy is a well-described treatment modality for psoriasis.	2011	21271993
polymorphisms of glutathione s-transferase µ and ?, mdr1 and vegf genes as risk factors of bladder cancer: a case-control study.	objective:: the present study was aimed at examining the local distribution of gstm1, gstt1, mdr1, and vegf gene polymorphisms as possible risk factors contributing to the development of bladder cancer among the population from canary islands, spain. materials and methods:: the genotypes were determined by pcr-based methods in a hospital-based case-control study consisting of 119 cases and 110 controls. the socio-demographic and clinicopathologic data were collected, including the smoking habits ...	2011	21292509
genetically depauperate in the continent but rich in oceanic islands: cistus monspeliensis (cistaceae) in the canary islands.	population genetic theory holds that oceanic island populations are expected to have lower levels of genetic variation than their mainland counterparts, due to founder effect after island colonization from the continent. cistus monspeliensis (cistaceae) is distributed in both the canary islands and the mediterranean region. numerous phylogenetic results obtained in the last years allow performing further phylogeographic analyses in cistus.	2011	21347265
tissue oxygen tension monitoring: will it fill the void?	the holy grail of circulatory monitoring is an accurate, continuous and relatively noninvasive means of assessing the adequacy of organ perfusion. this could be then advantageously used to direct therapeutic interventions to prevent both under-treatment and over-treatment and thus improve outcomes. however, in view of the heterogeneous response (adaptive or maladaptive) of different organs to various shock states, any monitor of perfusion adequacy cannot reflect every organ system, but should at ...	2011	21358405
mitochondrial dna effects on fitness in drosophila subobscura.	we tested different fitness components on a series of conspecific mtdna haplotypes, detected by rflps in drosophila subobscura. additionally, haplotype viii, endemic to the canary islands, was tested upon its own native nuclear dna background and upon that of the rest of mtdnas tested herein. we found that both nuclear and mitochondrial dna can have a significant effect upon their hosts' fitness, and that negative selection is one of the mechanisms that can intervene in this species' mtdna haplo ...	2011	21364694
comparative analysis of copy number variation detection methods and database construction.	array-based detection of copy number variations (cnvs) is widely used for identifying disease-specific genetic variations. however, the accuracy of cnv detection is not sufficient and results differ depending on the detection programs used and their parameters. in this study, we evaluated five widely used cnv detection programs, birdsuite (mainly consisting of the birdseye and canary modules), birdseye (part of birdsuite), penncnv, cghseg, and dnacopy from the viewpoint of performance on the aff ...	2011	21385384
high prevalence of asthma and atopy in the canary islands, spain.	to evaluate the prevalence of and risk factors for asthma and related conditions in the canaries, spain.	2011	21396215
[cardiovascular risk factors in spain in the first decade of the 21st century, a pooled analysis with individual data from 11 population-based studies: the darios study].	to estimate the prevalence of cardiovascular risk factors in individuals aged 35-74 years in 10 of spain's autonomous communities and determine the geographic variation of cardiovascular risk factors distribution.	2011	21397375
systemic mycosis caused by trichophyton spp. in an olive ridley sea turtle (lepidochelys olivacea): an immunohistochemical study.	a sub-adult female olive ridley sea turtle (lepidochelys olivacea) was found floating off the coast of gran canaria, canary islands, spain. clinical and pathological findings: the turtle was lethargic and weak, and died one day after it was found. necropsy was performed and selected samples of lung and liver were routinely processed for histopathological and immunohistological studies. grossly, round, ulcerative lesions were observed on the rear flippers. the liver, spleen, coelomic wall, gastri ...	2011	21409736
a comparison of antibody responses to commercial equine influenza vaccines following annual booster vaccination of national hunt horses - a randomised blind study.	protection against equine influenza virus (eiv) relies largely on the production of circulating antibodies specific for the haemagglutinin (ha) glycoprotein. the objective of this study was to determine the antibody response of national hunt horses in training to booster vaccination. the antibody response to the six equine influenza vaccines available in ireland (three whole inactivated vaccines, two subunit vaccines and a canary pox recombinant vaccine), was monitored by single radial haemolysi ...	2011	21419776
sideritis spp.: uses, chemical composition and pharmacological activities--a review.	the genus sideritis (lamiaceae) comprises more than 150 perennial and annual vegetal species widely distributed in the mediterranean area, together with canary and madeira islands. it is a controversial botanic genus, with a complex taxonomical classification due to the high number of hybridizations that occur between species; their study requires a deep research experience. sideritis species have been traditionally used as teas for feeding, flavoring agents and in folk medicine as antiinflammat ...	2011	21420484
contamination of cheese by polycyclic aromatic hydrocarbons in traditional smoking. influence of the position in the smokehouse on the contamination level of smoked cheese.	this paper sets out to determine the polycyclic aromatic hydrocarbon (pah) contamination degree of a traditionally smoked cheese: herreño cheese, which comes from one of the canary islands. its pah profile is thoroughly studied by means of gas chromatography-mass spectrometry in sim mode, and compared with that of an unsmoked cheese. furthermore, a parameter not previously studied is evaluated, namely the influence of the position of the individual cheeses in the smokehouse on their pah contamin ...	2011	21426955
analysis of the spatial variation of bovine tuberculosis disease risk in spain (2006-2009).	in this study we explored the spatial variation of bovine tuberculosis (btb) risk of being positive, new positive or persistently positive, as well as the risk of eliminating btb in positive herds throughout spain from 2006 to 2009 by means of hierarchical bayesian models. the results of the models showed that the risk of infection (positive or new positive herds), persistence and elimination was lower in counties located in north and north-eastern of spain, and in the balearic and canary island ...	2011	21429605
acid epimerization of 20-keto pregnane glycosides is determined by 2d-nmr spectroscopy.	carbohydrates influence many essential biological events such as apoptosis, differentiation, tumor metastasis, cancer, neurobiology, immunology, development, host-pathogen interactions, diabetes, signal transduction, protein folding, and many other contexts. we now report on the structure determination of pregnane glycosides isolated from the aerial parts of ceropegia fusca bolle (asclepiadaceae). the observation of cicatrizant, vulnerary and cytostatic activities in some humans and animals of c ...	2011	21431831
mitochondrial dna in basque descendants from the city of trinidad, uruguay: uruguayan- or basque-like population?	like other countries in the americas, during its colonization uruguay was the recipient of immigrants from several ethnic groups from europe, as well as of enslaved africans. after its independence in 1830, basques were the first group of europeans to arrive in the country. in this paper, we aim to contribute to the understanding of the process of integration of these migratory waves into the uruguayan society. for that purpose, individuals of basque origin from the city of trinidad, uruguay, we ...	2011	21453004
[current peritoneal dialysis compared with haemodialysis: medium-term survival analysis of incident dialysis patients in the canary islands in recent years].	important differences in patient survival exist between peritoneal dialysis (pd) and haemodialysis (hd). several different studies have shown that pd yields a better survival rate than hd in the first and second years of treatment, especially in younger patients and non-diabetic patients with low comorbidity, whereas hd produces better results in diabetic patients, elderly patients, and in patients with greater comorbidity. in recent years, interesting changes have occurred in pd units in the ca ...	2011	21461011
phylogeography of the atlanto-mediterranean sea cucumber holothuria (holothuria) mammata: the combined effects of historical processes and current oceanographical pattern.	we assessed the genetic structure of populations of the widely distributed sea cucumber holothuria (holothuria) mammata grube, 1840, and investigated the effects of marine barriers to gene flow and historical processes. several potential genetic breaks were considered, which would separate the atlantic and mediterranean basins, the isolated macaronesian islands from the other locations analysed, and the western mediterranean and aegean sea (eastern mediterranean). we analysed mitochondrial 16s a ...	2011	21463375
north african influences and potential bias in case-control association studies in the spanish population.	despite the limited genetic heterogeneity of spanish populations, substantial evidences support that historical african influences have not affected them uniformly. accounting for such population differences might be essential to reduce spurious results in association studies of genetic factors with disease. using ancestry informative markers (aims), we aimed to measure the african influences in spanish populations and to explore whether these might introduce statistical bias in population-based ...	2011	21479138
depth profile of (236)u/(238)u in soil samples in la palma, canary islands.	the vertical distribution of the (236)u/(238)u isotopic ratio was investigated in soil samples from three different locations on la palma (one of the seven canary islands, spain). additionally the (240)pu/(239)pu atomic ratio, as it is a well establish tool for the source identification, was determined. the radiochemical procedure consisted of a u separation step by extraction chromatography using uteva(®) resin (eichrom technologies, inc.). afterwards pu was separated from th and np by anion ex ...	2011	21481502
exercise tiger: assessing the bcm impact of the 2012 olympics on canary wharf.	in this paper, collective corporate resilience is studied to see how a culture of sharing information and planning may assist other business communities to prepare for future events. the london 2012 summer olympic games will see huge opportunity for businesses in london, and across europe, but not without cost. canary wharf lies in the heart of london's docklands and less than three miles from the olympic park at stratford. purpose-built as a business district, it accommodates a working populati ...	2011	21482513
chestnut cultivar diversification process in the iberian peninsula, canary islands, and azores.	this is a large-scale molecular study based on simple sequence repeat (ssr) loci of the diversification process in chestnut cultivars from portugal and spain, from the northern iberian peninsula to the canary islands and the azores. a total of 593 grafted chestnut trees (castanea sativa mill.) were analysed with 10 ssrs: 292 from portugal and 301 from spain. some of the trees studied were more than 300 years old. accessions were analysed using a model-based bayesian procedure to assess the geogr ...	2011	21491973
culture-induced chromosome abnormalities: the canary in the mine.		2011	21493156
poxvirus infection in stone curlews in the canary islands.		2011	21493519
benzoxacystol, a benzoxazine-type enzyme inhibitor from the deep-sea strain streptomyces sp. ntk 935.	benzoxacystol, a new 1,4-benzoxazine-type metabolite, was produced by strain ntk 935, a marine member of the streptomyces griseus 16s rrna clade, isolated from deep-sea sediment collected from the canary basin. the structure of benzoxacystol was determined by mass spectrometry, nmr experiments and x-ray analysis. the compound showed an inhibitory activity against the enzyme glycogen synthase kinase 3β and a weak antiproliferative activity against mouse fibroblast cells.the journal of antibiotics ...	2011	21505471
mapping unexplored genomes ii: genetic architecture of species differences in the woody sonchus alliance (asteraceae) in the macaronesian islands.	despite numerous, well-documented evolutionary histories of plant groups which underwent rapid radiation in various oceanic archipelagos, very little is known about the genetic basis of species differences and adaptive radiation. this paper represents the first such study in the macaronesian islands using non-model endemic plants, the woody sonchus alliance. here i inferred the genetic basis of species differences between two canary island endemics, the herbaceous perennial, shade tolerant lactu ...	2011	21505946
trypanosoma culicavium sp. nov., an avian trypanosome transmitted by culex mosquitoes.	a new avian trypanosome, trypanosoma culicavium sp. nov., isolated from culex mosquitoes, is described on the basis of naturally and experimentally infected vectors and bird hosts, localization in the vector, morphological characters and molecular data. this study provides the first comprehensive description of a trypanosome species transmitted by mosquitoes, in which parasites form plugs and rosettes on the stomodeal valve. trypanosomes occurred as long epimastigotes and short trypomastigotes i ...	2011	21515704
new bicyclotridecane c(15) nonterpenoid bromoallenes from laurencia marilzae.	nonterpenoid bromoallenes possessing a novel skeleton that incorporates an unprecedented [5.5.1]bicyclotridecane ring system, marilzabicycloallenes a-d (1-4), were isolated from specimens of laurencia marilzae collected on the canary islands. the framework of these metabolites strongly reinforces braddock's hypothesis concerning the biosynthesis via electrophilic bromination of the obtusallene family.	2011	21517101
characteristic phenolic composition of single-cultivar red wines of the canary islands (spain).	the detailed phenolic composition of five single-cultivar (baboso negro, listán negro, negramoll, tintilla, and vijariego negro) young and aged (vintages 2005-2009) red wines of the canary islands has been determined by hplc-dad-esi-ms(n). despite the total monomeric anthocyanin content decreasing for older wines in each set of single-cultivar wines, the corresponding anthocyanin profiles remained almost unchanged. although all wine anthocyanin profiles were dominated by malvidin 3-glucoside, t ...	2011	21548631
high prevalence of hypovitaminosis d in medical students in gran canaria. canary islands (spain).	background: vitamin d deficiency has been described in many diseases and indeed in the general population. however fewer reports have been published in young and healthy people. vitamin d deficiency should not be found in medical students of the canary islands, because they have all the resources to avoid it. objective: to estimate the prevalence of vitamin d deficiency in a population of medical students of both gender from the university of las palmas de gran canaria. methods: 103 medical stud ...	2011	21555257
non-human viruses developed as therapeutic agent for use in humans.	viruses usually infect a restricted set of host species, and only in rare cases does productive infection occur outside the natural host range. infection of a new host species can manifest as a distinct disease. in this respect, the use of non-human viruses in clinical therapy may be a cause for concern. it could provide the opportunity for the viruses to adapt to the new host and be transferred to the recipient's relatives or medical caretakers, or even to the normal host species. such environm ...	2011	21560181
animal sentinels for environmental and public health.	studies of the effects of environmental exposures on domestic and wild animals can corroborate or inform epidemiologic studies in humans. animals may be sensitive indicators of environmental hazards and provide an early warning system for public health intervention, as exemplified by the iconic canary in the coal mine. this article illustrates the application of animal sentinel research to elucidate the effects of exposure to traditional and emerging contaminants on human health. focusing on env ...	2011	21563712
cnvassoc: association analysis of cnv data using r.	abstract: background: copy number variants (cnv) are a potentially important component of the genetic contribution to risk of common complex diseases. analysis of the association between cnvs and disease requires that uncertainty in cnv copy-number calls, which can be substantial, be taken into account; failure to consider this uncertainty can lead to biased results. therefore, there is a need to develop and use appropriate statistical tools. to address this issue, we have developed cnvassoc, an ...	2011	21609482
seroprevalence of rickettsia typhi and rickettsia conorii infections in the canary islands (spain).	objective: the aim of this work was to evaluate the prevalence of past infection due to rickettsia typhi and rickettsia conorii in the canary islands (spain). methods: a representative sample of the population of the seven islands, formed of 662 people aged between 5 and 75 years (368 females, 294 males), was analyzed. epidemiological data were obtained by direct survey. the detection of serum igg antibodies against both microorganisms was based on an indirect immunofluorescence test, considered ...	2011	21612963
greater seasonal carbon gain across a broad temperature range contributes to the invasive potential of phalaris arundinacea (poaceae; reed canary grass) over the native sedge carex stricta (cyperaceae).	• premise of the study: most invasive plants grow faster and produce more biomass than the species that they displace, but physiological mechanisms leading to invasive success are poorly understood. to foster novel control approaches, our goal was to determine whether the grass phalaris arundinacea possessed superior physiological strategies that contributed to its success over native sedges. • methods: data for spring, summer, and autumn diel gas-exchange, leaf morphology, and nitrogen content ...	2011	21613081
the analysis of groel gene in salmonella enterica subspecies enterica serovar typhimurium isolated from avians by pcr-restriction fragment length polymorphism method.	salmonella enterica subspecies enterica serovar typhimurium causes food-borne outbreaks and systemic diseases in humans and animals. groel gene (also known as mopa gene in s. typhimurium), possessing conserved sequence, plays an important role in invasion of bacteria. the purpose of present study was to identify the polymorphism of groel gene among different avians in different regions by pcr-rflp method. fifty two s. typhimurium isolates (broiler (n = 13), layer (n = 12), duck (n = 5), goose (n ...	2011	21312060
a customizable 3-dimensional digital atlas of the canary brain in multiple modalities.	songbirds are well known for their ability to learn their vocalizations by imitating conspecific adults. this uncommon skill has led to many studies examining the behavioral and neurobiological processes involved in vocal learning. canaries display a variable, seasonally dependent, vocal behavior throughout their lives. this trait makes this bird species particularly valuable to study the functional relationship between the continued plasticity in the singing behavior and alterations in the anat ...	2011	21565273
transpiration of urban forests in the los angeles metropolitan area.	despite its importance for urban planning, landscape management, and water management, there are very few in situ estimates of urban-forest transpiration. because urban forests contain an unusual and diverse mix of species from many regions worldwide, we hypothesized that species composition would be a more important driver of spatial variability in urban-forest transpiration than meteorological variables in the los angeles (california, usa) region. we used constant-heat sap-flow sensors to moni ...	2011	21639035
atrial fibrillation: new-onset af in women-an independent risk factor or a 'canary in a coal mine'?		2011	21647182
occupational allergy to birds within the population of polish bird keepers employed in zoo gardens.	objectives: to evaluate the risk factors for the development of occupational allergy to birds among polish zoo garden keepers. methods: a total of 200 bird zookeepers employed in the polish zoo gardens in lódz, warsaw, gdansk, chorzów and plock and exposed occupationally to bird allergens were examined using a questionnaire, skin prick tests (spts) to common allergens and bird allergens, spirometry and cytograms of nasal swab. the level of total ige in serum and serum-specific ige to parrot, can ...	2011	21805139
lox-1 transcription.	the importance of the lectin-like oxidized ldl receptor (lox-1) gene in cardiovascular and other diseases is slowly being revealed. lox-1 gene expression appears to be a "canary in a coal mine" for atherogenesis, being strongly up-regulated early on in a number of cell types when they are activated, and predicting the sites of future disease. from this early time point the lox-1 protein often participates in the disease process itself. while gene/protein expression can be regulated on a multipli ...	2011	21796333
occurrence of contamination by controlled substances in euro banknotes from the spanish archipelago of the canary islands.	the social problems of drug abuse are a matter of increasing global problem. nowadays, international agencies need fresh methods to monitor trends of the use of illicit drugs. in this sense, small amounts of drugs are transferred to banknotes and they could be detected and quantified. an analytical procedure based upon extraction with organic solvent, liquid chromatography separation, and mass spectrometric detection allowed the identification of 21 drugs and metabolites in 120 used euro banknot ...	2011	21790602
herbaspirillum canariense sp. nov., herbaspirillum aurantiacum sp. nov. and herbaspirillum soli sp. nov., three new species isolated in tenerife (canary islands).	three gram-negative, motile and slightly curved rod-shaped bacterial isolates, suemi03(t), suemi08(t) and suemi10(t), were isolated an old volcanic mountain soil in tenerife (canary islands). the three strains are able to produce siderophores in vitro and were phylogenetically related with species of genus herbaspirillum from which their close related species was h. seropedicae. the identity of 16s rrna gene sequences ranged from 99.2 and 99.6% among the strains suemi03(t), suemi08(t) and suemi1 ...	2011	21788228
[evidence against the myth of adjustment problems of people with high intellectual abilities.]	evidence against the myth of adjustment problems of people with high intellectual abilities. personal and social adjustment of high-ability children and adolescents is a very important issue in the specialized literature. the differences found between data for and against appropriate adjustment in gifted children and adolescents could be explained by conceptual or methodological biases. in this work, the relation between adjustment and high abilities are contrasted in a sample of teenagers from ...	2011	21774886
diagnosis of imported canine filarial infections in germany 2008 - 2010.	filarial infections of dogs are attracting attention across europe because of the risk of spread into previously non-endemic areas (e.g. dirofilaria repens with culicidae as vectors) and as emerging zoonotic agents. the occurrence of filarial infections in german dogs has been analysed based on 8,545 samples collected either from imported animals or following travel into endemic regions. all samples were tested by means of modified knott's test and heartworm antigen assay within the period 2008 ...	2011	21739376
a new endogean, anophthalmous species of parazuphium jeannel from northern morocco (coleoptera, carabidae), with new molecular data for the tribe zuphiini.	a new species of the genus parazuphium (coleoptera, carabidae, zuphiini), parazuphium aguileraisp. n., is described from the tingitan peninsula in north morocco. the only known specimen was found under a large deeply buried boulder, and belongs to an anophthalmous, depigmented and flattened species. this is the second species of blind parazuphium known so far, the other being parazuphium feloi machado 1998 from a lava tube in the canary islands. molecular data of the only known parazuphium aguil ...	2011	21747680
the link between erectile and cardiovascular health: the canary in the coal mine.	lifestyle and nutrition have been increasingly recognized as central factors influencing vascular nitric oxide (no) production and erectile function. this review underscores the importance of no as the principal mediator influencing cardiovascular health and erectile function. erectile dysfunction (ed) is associated with smoking, excessive alcohol intake, physical inactivity, abdominal obesity, diabetes, hypertension, and decreased antioxidant defenses, all of which reduce no production. better ...	2011	21624550
global biodiversity and phylogenetic evaluation of remipedia (crustacea).	remipedia is one of the most recently discovered classes of crustaceans, first described in 1981 from anchialine caves in the bahamas archipelago. the class is divided into the order enantiopoda, represented by two fossil species, and nectiopoda, which contains all known extant remipedes. since their discovery, the number of nectiopodan species has increased to 24, half of which were described during the last decade. nectiopoda exhibit a disjunct global distribution pattern, with the highest abu ...	2011	21625553
the cat that caught the canary: what to do with single-molecule trapping.	it has recently become possible to trap individual fluorescent biomolecules in aqueous solution by using real-time tracking and active feedback to suppress brownian motion. we propose areas of investigation in which anti-brownian electrokinetic (abel) trapping of single molecules is likely to lead to significant new insights into biomolecular dynamics.	2011	21710977
patients treated with plasmapheresis: a case review from university hospital of the canary islands.	plasmapheresis (pp) is a therapeutic apheresis technique used in the treatment of various renal and systemic diseases with varying degrees of proven clinical efficacy.	2011	21738245
experimental infection of domestic canaries (serinus canaria domestica) with mycoplasma gallisepticum: a new model system for a wildlife disease.	the ethical and logistical challenges inherent in experimental infections of wild-caught animals present a key limitation to the study of wildlife diseases. here we characterize a potentially useful domestic model for a wildlife disease that has been of particular interest in recent decades; that is, infection of north american house finches (carpodacus mexicanus) with mycoplasma gallisepticum, more commonly known as a worldwide poultry pathogen. seven domestic canaries (serinus canaria domestic ...	2011	21711192
validation of a gc-ms/ms method for simultaneous determination of 86 persistent organic pollutants in marine sediments by pressurized liquid extraction followed by stir bar sorptive extraction.	a multiresidue method for the analysis of 86 persistent pollutants in marine sediments at ultra-trace level has been developed and validated using pressurized liquid extraction (ple) and stir-bar sorptive extraction (sbse) coupled with thermal desorption and gas chromatography-triple quadrupole mass spectrometry (td-gc-ms/ms qqq). the compounds analyzed belong to various families such as polychlorinated biphenyls, polycyclic aromatic hydrocarbons, polybrominated diphenylethers, organophosphorus ...	2011	21723584
hemodynamics and metabolism at low versus moderate altitudes.	despite the higher prevalence of diabetes and hypertension in populations residing at moderate altitudes, mortality in these populations is lower than in populations residing at low altitudes. to examine whether metabolic and hemodynamic differences can explain this apparent paradox, we performed a cross-sectional study of a general population sample recruited in the canary islands, spain (n=6729). we recorded altitude of residence, age, heart rate, blood pressure, body mass index, social class, ...	2011	21718166
use of ionic liquid aggregates of 1-hexadecyl-3-butyl imidazolium bromide in a focused-microwave assisted extraction method followed by high-performance liquid chromatography with ultraviolet and fluorescence detection to determine the 15+1 eu priority pahs in toasted cereals ("gofios").	a focused-microwave assisted extraction method using aggregates of the ionic liquid (il) 1-hexadecyl-3-butylimidazolium bromide (hdbim-br) followed by high-performance liquid chromatography (hplc) with ultraviolet (uv) detection and single-channel fluorescence detection (fld) has been developed for the determination of polycyclic aromatic hydrocarbons (pahs) in toasted cereals ("gofios") of different nature (wheat, barley, rye, and maize corn) from the canary islands, spain. the optimized hplc-u ...	2011	21726759
Consequences of plant-pollinator and floral-herbivore interactions on the reproductive success of the Canary Islands endemic Canarina canariensis (Campanulaceae).	• Premise of the study: Pollination is a critical phase for plant reproduction, but ecological and evolutionary outcomes by pollinators may be counteracted by floral herbivores. These interacting assemblages may also be altered (directly or indirectly) by introduced species, especially on oceanic islands. In this study, we analyzed the effects of opportunistic nectar-feeding passerine birds and native (semi-slugs) and introduced (rats) floral herbivores on the reproductive success of Canarina ca ...	2011	21900611
the potential impact of reproducibility of gleason grading in men with early stage prostate cancer managed by active surveillance: a multi-institutional study.	we evaluated the reproducibility of gleason grading as relevant to the clinical treatment of men on active surveillance.	2011	21679996
gnrh - a missing link between testosterone concentrations in yolk and plasma and its intergenerational effects.	despite the strong interest in hormone-mediated maternal effects two key questions concerning their mechanisms are as yet unanswered: first, whether the deposition of hormones in the egg yolk is coupled with the levels of these hormones in the maternal circulation, and second, whether epigenetic changes as induced by embryonic exposure to maternal yolk hormones impinge on yolk hormone deposition at adulthood. we investigated the responsiveness to gonadotropin-releasing hormone (gnrh) in female c ...	2011	21829476
a multi-gene approach reveals a complex evolutionary history in the cyanistes species group.	quaternary climatic oscillations have been considered decisive in shaping much of the phylogeographic structure around the mediterranean basin. within this paradigm, peripheral islands are usually considered as the endpoints of the colonization processes. here, we use nuclear and mitochondrial markers to investigate the phylogeography of the blue tit complex (blue tit cyanistes caeruleus, canary blue tit c. teneriffae and azure tit c. cyanus), and assess the role of the canary islands for the ge ...	2011	21880092
multisensory non-photoperiodic cue advances the onset of seasonal breeding in island canaries (serinus canaria).	in most temperate zone vertebrates, photoperiodic change plays the major role in the timing of seasonal breeding. however, direct environmental stimuli such as temperature, rainfall, or availability of food are thought to be important for fine-tuning breeding activities. building on evidence from wild island canaries (serinus canaria), the authors had shown advancing effects of green vegetation on breeding under captive, short-day conditions. so far, the precise, sensory modalities of this stimu ...	2011	21921297
Is cystic fibrosis genetic medicine's canary?	In 1989 the gene that causes cystic fibrosis (CF) was identified in a search accompanied by intense anticipation that the gene, once discovered, would lead rapidly to gene therapy. Many hoped that the disease would effectively disappear. Those affected were going to inhale vectors packed with functioning genes, which would go immediately to work in the lungs. It was a bewitching image, repeatedly invoked in both scientific and popular texts. Gene therapy clinical trials were carried out with a r ...	2011	21857124
Oceanic islands are not sinks of biodiversity in spore-producing plants.	Islands have traditionally been considered as migratory and evolutionary dead ends for two main reasons: island colonizers are typically assumed to lose their dispersal power, and continental back colonization has been regarded as unlikely because of niche preemption. The hypothesis that islands might actually represent dynamic refugia and migratory stepping stones for species that are effective dispersers, and in particular, for spore-producing plants, is formally tested here, using the archipe ...	2011	22084108
characterizing mortality effects of particulate matter size fractions in the two capital cities of the canary islands.	most of the studies differentiating the effect of size-classified particulate matter (pm) exposure have been carried out in cities where the average levels of fine particles (pm(2.5)) were higher than those of coarse particles (pm(10-2.5)). these studies have suggested that pm(2.5) is associated with daily mortality, but there is only limited evidence that pm(10-2.5) is independently associated with mortality. the citizens of the canary islands are exposed to pm which is highly influenced by min ...	2011	22099912
Symbolic play connects to language through visual object recognition.	Object substitutions in play (e.g. using a box as a car) are strongly linked to language learning and their absence is a diagnostic marker of language delay. Classic accounts posit a symbolic function that underlies both words and object substitutions. Here we show that object substitutions depend on developmental changes in visual object recognition: 18- to 30-month old children (n = 63) substitute objects in play after they have developed the adult-like ability to recognize common objects from ...	2011	21884329
Isolation and characterization of polymorphic microsatellite loci in Aleurodicus dispersus (Hemiptera, Aleyrodidae).	Ten microsatellite markers were isolated and characterized from Aleurodicus dispersus, the spiraling whitefly, an exotic pest species that is considered to be one of the most serious agricultural pests on Hainan Island, China. The polymorphism of these loci was examined in individual whiteflies from Hainan Island and from the Canary Islands. All loci were polymorphic, with two to four alleles per locus. Mean observed and expected heterozygosity values were 0.773 and 0.585, respectively. T ...	2011	22009865
seroprevalence of angiostrongylus cantonensis in wild rodents from the canary islands.	angiostrongylus cantonensis is a lungworm of rats (muridae) that is the causative agent of human cerebral angiostrongyliasis. the life cycle of a. cantonensis involves rats and mollusks as the definitive and intermediate hosts, respectively. this study was designed to increase the knowledge about the occurrence and distribution of a. cantonensis in its definitive host in the canary islands, using parasitological and serological analysis in different areas and age groups.	2011	22110752
Sweepoviruses cause disease in sweet potato and related Ipomoea spp.: fulfilling Koch's postulates for a divergent group in the genus begomovirus.	Sweet potato (Ipomoea batatas) and related Ipomoea species are frequently infected by monopartite begomoviruses (genus Begomovirus, family Geminiviridae), known as sweepoviruses. Unlike other geminiviruses, the genomes of sweepoviruses have been recalcitrant to rendering infectious clones to date. Thus, Koch's postulates have not been fullfilled for any of the viruses in this group. Three novel species of sweepoviruses have recently been described in Spain: Sweet potato leaf curl Lanzarote virus ...	2011	22073314
pathogenic leptospira spp. in wild rodents, canary islands, spain.		2011	21888829
Cryptosporidium spp. parasitize exotic birds that are commercialized in markets, commercial aviaries, and pet shops.	The purpose of this study was to genetically characterize and phylogenetically analyze the Cryptosporidium spp. isolated from exotic birds commercialized in popular markets, commercial aviaries, and pet shops located in Rio de Janeiro, Brazil. Fecal samples from individually housed birds were collected and subjected to centrifuge-flotation technique using saturated sugar solution. DNA was isolated from Cryptosporidium positive samples, and 18S subunit rDNA was amplified and processed using neste ...	2011	21922240
spiropyran-amidine: a molecular canary for visual detection of carbon dioxide gas.		2011	21905137
prevalence of general and abdominal obesity in the adult population of spain, 2008-2010: the enrica study.	this is the first study to report the prevalence of general obesity and abdominal obesity (ao) in the adult population of spain based on measurements of weight, height and waist circumference. the data are taken from the enrica study, a cross-sectional study carried out between june 2008 and october 2010 in 12,883 individuals representative of the non-institutionalized population on spain aged 18 years and older. anthropometry was performed under standardized conditions in the households by trai ...	2011	22151906
Negative effects of yolk testosterone and ticks on growth in canaries.	Maternal yolk hormones in bird eggs are thought to adjust the offspring to the post-hatching environment. This implies that the effects of maternal yolk hormones should vary with the post-hatching environment, but to date such context-dependency has largely been ignored. We experimentally increased yolk testosterone concentrations in canary eggs and simultaneously manipulated the post-hatching context via an experimental tick-infestation of the chicks. This allows us to evaluate the context-depe ...	2011	21898851
Lipolysis and proteolysis profiles of fresh artisanal goat cheese made with raw milk with 3 different fat contents.	The objective of this study was to describe the proteolysis and lipolysis profiles in goat cheese made in the Canary Islands (Spain) using raw milk with 3 different fat contents (0.5, 1.5, and 5%) and ripened for 1, 7, 14, and 28 d. ß-Casein was the most abundant protein in all cheeses and at all ripening times. Quantitative analysis showed a general decrease in caseins as ripening progressed, and degradation rates were higher for a(S1)-casein than for ß-casein and a(S2)-casein. Furthermore, the ...	2011	22118069
distribution and genetic variation of hymenolepidid cestodes in murid rodents on the canary islands (spain).	in the canary islands there are no previous data about tapeworms (cestoda) of rodents. in order to identify the hymenolepidid species present in these hosts, a survey of 1,017 murine (349 rattus rattus, 13 rattus norvegicus and 655 mus musculus domesticus) was carried out in the whole archipelago. molecular studies based on nuclear its1 and mitochondrial coi loci were performed to confirm the identifications and to analyse the levels of genetic variation and differentiation.	2011	21943096
a new species of spauligodon (nematoda: oxyurida: pharyngodonidae) in geckos from s?o nicolau island (cape verde) and its phylogenetic assessment.	abstract a new nematode species of spauligodon, spauligodon nicolauensis n. sp. from geckos tarentola bocagei and tarentola nicolauensis on the island of s?o nicolau, cape verde, is described. the new nematode was found in the pellets obtained directly from the geckos in a non-invasive fashion and its identity was assessed both at morphologic and genetic levels. the new species has morphological similarities with spauligodon tarentolae spaul, 1926, also parasitizing geckos from the canary isla ...	2011	21942458
a fast method using a new hydrophilic-lipophilic balanced sorbent in combination with ultra-high performance liquid chromatography for quantification of significant bioactive metabolites in wines.	this manuscript describes the development and validation of an ultra-fast, efficient, and high throughput analytical method based on ultra-high performance liquid chromatography (uhplc) equipped with a photodiode array (pda) detection system, for the simultaneous analysis of fifteen bioactive metabolites: gallic acid, protocatechuic acid, (-)-catechin, gentisic acid, (-)-epicatechin, syringic acid, p-coumaric acid, ferulic acid, m-coumaric acid, rutin, trans-resveratrol, myricetin, quercetin, ci ...	2011	22063514
Neoparamoeba branchiphila infections in moribund sea urchins Diadema aff. antillarum in Tenerife, Canary Islands, Spain.	A total of 109 sea urchins from 3 species collected in 2 localities off the coast of Tenerife Island, Spain, were examined for the presence of free-living amoebae in their coelomic fluid. Amoeba trophozoites were isolated exclusively from moribund individuals of long-spined sea urchins Diadema aff. antillarum (Philippi) (Echinoidea, Echinodermata) that manifested lesions related to sea urchin bald disease on their tests (16 out of 56 examined). No amoebae were detected in Arbacia lixula (L.) and ...	2011	21932534
j. m. despréaux' lichens from the canary islands and west africa: an account of a 19th century collection found in an english archive.	this is an historical and descriptive account of 28 herbarium specimens, 27 lichens and an alga, found in the archives of charles chalcraft, a descendant of the bedford family, who were dye manufacturers in leeds, england, in the 19th century. the lichens comprise 13 different morphotypes collected in the canary islands and west africa by the french botanist j. m. despréaux between 1833 and 1839. the collections include samples of "roccella fuciformis", "r. phycopsis" and "r. tinctoria" (includi ...	2011	21941694
salmonellosis and charter tourism: epidemiology and trends of imported human cases to norway from the canary islands and thailand, 1994-2008.	summarymore than 70% of reported human salmonella infections in norway are infected abroad. the canary islands and thailand are two of the most popular charter tourist destinations for norwegians. using surveillance data for the years 1994-2008, and denominator data on travel to the canary islands 2000-2008 and to thailand 1997-2008, we present the epidemiology and trends of salmonella infections in norwegian tourists to these destinations. we found a declining trend in risk of salmonellosis in ...	2011	22051449
determinants of blood lead levels in children: a cross-sectional study in the canary islands (spain).	the adverse effects of lead exposure on children are well known. low blood lead levels (bll) produce neurodevelopmental delay and cognitive disorders. however, since bll thresholds for adverse effects on children's health are not known, the children population at risk of excessive lead exposure still has to be identified. this study was aimed at evaluating bll in a children population of gran canaria (canary islands, spain). up to our knowledge, this is the first study to report on bll in this p ...	2011	22104625
impaired fasting glucose, ancestry and waist-to-height ratio: main predictors of incident diagnosed diabetes in the canary islands.	aims: to estimate the incidence rate and risk factors for diabetes in the canary islands. methods: a total of 5521 adults without diabetes were followed for a median of 3.5 years. incident cases of diabetes were self-declared and validated in medical records. the following factors were assessed by cox regression to estimate the hazard ratios for diabetes: impaired fasting glucose (5.6 mmol/l ≤ fasting glucose ≤ 6.9 mmol/l), bmi, waist-to-height ratio (≥ 0.55), insulin resistance (defined as tr ...	2011	21883429
molecular survey of apicomplexa in podarcis wall lizards detects hepatozoon, sarcocystis and eimeria species.	abstract the occurrence of apicomplexan parasites in podarcis wall lizards from the iberian peninsula and balearic islands was studied by amplification and sequencing of the 18s rrna gene. species from three genera, hepatozoon, sarcocystis and eimeria were detected. the phylogenetic analysis of the 18s rrna gene provides unexpected insights into the evolutionary history of these parasites. all hepatozoon specimens were recovered as part of a clade already identified in lizards from north afric ...	2011	22128850
diversity of acetic acid bacteria present in healthy grapes from the canary islands.	the identification of acetic acid bacteria (aab) from sound grapes from the canary islands is reported in the present study. no direct recovery of bacteria was possible in the most commonly used medium, so microvinifications were performed on grapes from tenerife, la palma and lanzarote islands. up to 396 aab were isolated from those microvinifications and identified by 16s rrna gene sequencing and phylogenetic analysis. with this method, acetobacter pasteurianus, acetobacter tropicalis, glucono ...	2011	21903289
avoidable costs of physical treatments for chronic back, neck and shoulder pain within the spanish national health service: a cross-sectional study.	abstract: background: back, neck and shoulder pain are the most common causes of occupational disability. they reduce health-related quality of life and have a significant economic impact. many different forms of physical treatment are routinely used. the objective of this study was to estimate the cost of physical treatments which, despite the absence of evidence supporting their effectiveness, were used between 2004 and 2007 for chronic and non-specific neck pain (np), back pain (bp) and shou ...	2011	22188790
factors associated with knowledge and control of arterial hypertension in the canary islands.	introduction and objectives: to analyze the factors associated with knowledge and control of hypertension in the adult population of the canary islands (18-75 years). methods: we recruited a random sample of the general population aged ≥18 years. hypertension was defined as systolic/diastolic blood pressure ≥140/90 mmhg or known hypertension (self-declared, or controlled hypertension <140/90 mmhg). the bivariate association of known and controlled hypertension with age, sex, anthropometry, serum ...	2011	22209706
heaven it's my wife! male canaries conceal extra-pair courtships but increase aggressions when their mate watches.	many animals live in a communication network, an environment where individuals can obtain information about competitors or potential mates by observing interactions between conspecifics. in such an environment, interactants might benefit by changing their signalling behaviour in the presence of an audience. this audience effect seems widespread among species, has been observed during various types of interaction (e.g. intra-sexual vs. inter-sexual interaction) and varies according to the social ...	2011	21857945
determinants of specific food consumption in the canary islands (spain).	the consumption of specific functional foods (ff) and some determinants of ff item selection were assessed using a questionnaire administered to 1112 individuals in the canary islands (spain). food items considered were milk products: easily digestible milk (or milk low in lactose), milk enriched with vitamins and/or minerals, skimmed milk with soluble fiber, milk with royal jelly, milk with modified fatty acids (omega 3), milk products low in fat, pro-biotic foods (yoghurt and fermented milk) a ...	2011	21959777
a study of nutrient digestibility and growth performance of broiler chicks fed hairy and hairless canary seed (phalaris canariensis l.) products.	a nutrient retention study and a growth study were conducted with broiler chickens to evaluate the nutritive value and potential toxicity of 2 hairless canary seed products-hulled seed and groats (cultivar cdc maria), and one hairy hulled canary seed (cultivar keet). each treatment was replicated 6 times (6 groups of 4 birds each). the hairless canary seed groat, hairless hulled canary seed, and the hairy hulled canary seed contained 24.5, 21.8, and 16.3% cp; 7.1, 5.8, and 6.6% ether extract; 1. ...	2011	22080017
naturally occurring phytotoxins in allelopathic plants help reduce herbicide dose in wheat.	field studies were carried out to evaluate the influence of allelopathic plant water extracts applied alone or tank-mixed with a reduced herbicide dose on the weeds of wheat. water extracts of sorghum (sorghum bicolor (l.) moench.) + sunflower (helianthus annuus l.) + mulberry (morus alba l.) were used alone (each at 20 l ha(-1)) or combined with iodo + mesosulfuron (3.6 and 7.2 g active ingredient (a.i.) ha(-1); 25 and 50% of the recommended dose, respectively). the recommended dose of herbicid ...	2011	21854181
gastric endoscopic submucosal dissection assisted by a new traction method: the clip-band technique. a feasibility study in a porcine model (with video).	endoscopic submucosal dissection (esd) is the standard of care for treating gastric intramucosal neoplasias in japan. however, it is seldom performed in western countries, mainly because it is technically very challenging. several traction methods have been proposed to facilitate submucosal dissection, but they are usually not widely available or are difficult to apply.	2011	22032320
molecular survey of apicomplexa in podarcis wall lizards detects hepatozoon, sarcocystis and eimeria species.	abstract the occurrence of apicomplexan parasites in podarcis wall lizards from the iberian peninsula and balearic islands was studied by amplification and sequencing of the 18s rrna gene. species from three genera, hepatozoon, sarcocystis and eimeria were detected. the phylogenetic analysis of the 18s rrna gene provides unexpected insights into the evolutionary history of these parasites. all hepatozoon specimens were recovered as part of a clade already identified in lizards from north afric ...	2011	22176558
high-resolution record of the matuyama-brunhes transition constrains the age of javanese homo erectus in the sangiran dome, indonesia.	a detailed paleomagnetic study conducted in the sangiran area, java, has provided a reliable age constraint on hominid fossil-bearing formations. a reverse-to-normal polarity transition marks a 7-m thick section across the upper tuff in the bapang formation. the transition has three short reversal episodes and is overlain by a thick normal polarity magnetozone that was fission-track dated to the brunhes chron. this pattern closely resembles another high-resolution matuyama-brunhes (mb) transitio ...	2011	22106291
Next generation DNA sequencing technology delivers valuable genetic markers for the genomic orphan legume species, Bituminaria bituminosa.	ABSTRACT: BACKGROUND: Bituminaria bituminosa is a perennial legume species from the Canary Islands and Mediterranean region that has potential as a drought-tolerant pasture species and as a source of pharmaceutical compounds. Three botanical varieties have previously been identified in this species: albomarginata, bituminosa and crassiuscula. B. bituminosa can be considered a genomic 'orphan' species with very few genomic resources available. New DNA sequencing technologies provide an opportuni ...	2011	22171578
A comparison of antibody responses to commercial equine influenza vaccines following primary vaccination of Thoroughbred weanlings--a randomised blind study.	Many racing authorities, sales companies and equestrian bodies have mandatory vaccination policies for equine influenza (EI). The consequences of lack of vaccine efficacy include clinical disease, disruption to training programmes, the cancellation of equestrian events and the introduction of virus to susceptible populations. The correlation between antibody against the virus haemagglutinin and protection against influenza has been well established. The objective of this study was to compare the ...	2011	21983355
the genetic ghost of an invasion past: colonization and extinction revealed by historical hybridization in senecio.	hybridization is an important evolutionary factor in the diversification of many plant and animal species. of particular interest is that historical hybridization resulting in the origin of new species or introgressants has occurred between species now geographically separated by great distances. here, we report that senecio massaicus, a tetraploid species native to morocco and the canary islands, contains genetic material of two distinct, geographically separated lineages: a mediterranean linea ...	2011	22171696
granulomatous myocarditis caused by candida albicans in a canary (serinus canaria).	candida albicans is among the major agents of mucous membrane mycosis in humans and animals, with systemic and deep infections observed in immunocompromised hosts. we describe a case of fatal granulomatous myocarditis caused by c albicans in a 20-day-old canary (serinus canaria). the etiologic diagnosis was confirmed by identifying characteristic morphologic features of the organism, combined with histochemical staining, and followed by the use of ad hoc biomolecular analysis.	2011	22216721
cloacal fibrosarcoma in a canary (serinus canaria).	a 1-year-old, male canary (serinus canaria) with a history of an enlarged abdomen of several days duration died acutely and was submitted for necropsy. results revealed a yellow to tan hard mass, 2 cm in diameter, adherent to the cloacal wall. histologically, the mass was composed of interlacing bundles of pleomorphic spindle cells with numerous and bizarre mitotic figures. neoplastic cells were positive for vimentin and negative for desmin and actin and showed ultrastructural features (dilated ...	2011	22458183
food conditions affect yolk testosterone deposition but not incubation attendance.	in many bird species with hatching asynchrony, yolk androgens increase across the laying sequence. this has been hypothesized to represent a compensatory mechanism for disadvantages of later-hatching chicks - via positive effects of yolk androgens on early competitiveness and growth. however, the costs and benefits of this compensatory strategy probably depend on environmental factors determining the survival chances of the chicks such as the food conditions, which should, therefore, influence m ...	2012	22265816