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perinatal and neonatal infections: listeriosis. 1979112093
role of complement in the expression of delayed-type hypersensitivity in rats: studies with cobra venom factor.the hypothesis was tested that delayed-type hypersensitivity (dth) to the complement-activating bacterium listeria monocytogenes is initiated by complement-derived mediators that attract sensitized lymphocytes to reaction sites. to this end dth and acquired resistance to l. monocytogenes were measured in rats injected with cobra venom factor, a potent inactivator of c3. treatment with cobra venom factor reduced the hemolytic power of serum to less than 0.5% of the control value. such decomplemen ...1979313366
effects of cannabinoids on host resistance to listeria monocytogenes and herpes simplex virus.previous investigations from our laboratories have demonstrated that cannabinoids possess immunosuppressive properties. the present studies were designed to determine whether these agents decrease host resistance to infections with listeria monocytogenes and herpes simplex virus type 2. host resistance was measured by changes in the 50% lethal dose of the pathogen in cannabinoid-treated and control mice. the effect of cannabinoids on resistance to l. monocytogens was dose dependent. delta-9-tetr ...1979313368
inhibition of host resistance by nutritional hypercholesteremia.previous experiments showed that nutritionally induced hypercholesteremia in mice caused an increase in susceptibility to coxsackievirus b, with a marked suppression of cellular infiltrates in infected tissues and an increased mortality. the present studies demonstrated that a hypercholesteremic diet was associated with an inhibition in host resistance as measured by susceptibility to listeria monocytogenes infection and the growth of two transplanted syngeneic murine tumors. moreover, the abili ...1979317596
listeria monocytogenes: brain abscess or meningoencephalitis?a brain abscess caused by listeria monocytogenes developed in an immunosuppressed renal transplant patient. meningitis and meningoencephalitis from this organism were encountered in three other renal transplant recipients at this medical center during the past 4 years. focal neurologic deficits occurred in patients with either listeria abscess or meningoencephalitis. computerized tomography was a rapid aid to the diagnosis of abscess. immunosuppression has increased the incidence of central nerv ...1979370686
the variable response of bacteria to excess ferric iron in host tissues.the enhancement by exogenous ferric iron, both systemic and local, of the infectivity of 120 strains of bacteria, representing 17 genera, was measured in the skin of guinea-pigs. systemic iron enhanced only 23% of 115 strains, and local iron 49% of 71 strains. systemic iron, by an apparently anti-inflammatory action, depressed the size of lesions produced by 27 of the non-enhanced strains from nine of the genera tested. for most strains, the degree of enhancement was small, ranging from 2- to 8- ...1979372534
hexachlorobenzene-induced stimulation of the humoral immune response in rats.rats were fed diets containing 0, 500, 1000, and 2000 mg hcb/kg during a 3-week period. marked weight increases of spleen, popliteal and mesenteric lymph nodes and of the liver were found. histologically, the white pulp in the spleen was enlarged because of an increase in size of marginal zones and follicles. in addition, there was an increase of extramedullary hemopoiesis. in the lymph nodes, the number of high endothelial venules was increased at all dose levels. the number of neutrophils, bas ...1979378061
effects of bcg infection on the susceptibility of mouse macrophages to endotoxin.mice infected intravenously with mycobacterium bovis (bcg) are 100 to 1,000 times more sensitive to the lethal effects of bacterial lipopolysaccharides (lps). since bcg infection results in macrophage activation and lps may cause pathophysiological effects through interaction with this cell type, it was of interest to determine whether macrophages from bcg-infected animals were more susceptible to the toxic effects of lps in vitro. when lps-susceptible, c57bl/6 mice were infected with bcg, a sig ...1979378847
[inflammation and host resistance against bacteria. i.--increased resistance against listeria monocytogenes and salmonella typhimurium in mice, following their treatment with bradykinin, kallidin and methionyl-lysyl-bradykinin (author's transl)].mice pretreated with kinins are more resistant to a lethal challenge of listeria monocytogenes. the multiplication of listeria is decreased in the liver and spleen and the blood clearance of salmonella typhi-murium is increased.1979393161
indirect sandwich enzyme-linked immunosorbent assay for rapid detection of haemophilus influenzae type b infection.we report the development and testing of an enzyme-linked immunosorbent assay with excellent sensitivity for the detection of haemophilus influenzae type b (hi(b)) antigen in clinical specimens from patients with hi(b) meningitis. the assay, an indirect sandwich technique, uses polystyrene balls as a solid phase and an alkaline phosphatase-labeled goat anti-rabbit globulin conjugate. specimens are incubated with polystyrene balls armed with burro anti-hi(b) antiserum, and recognition antibody is ...1979393714
listeria monocytogenes pericarditis and myocardial abscess. 1979286406
outcome of listeria monocytogenes infection in compromised and non-compromised adults; a comparative study of seventy-two cases.the mortality in listeric meningitis and septicaemia, the two main clinical manifestations of the infection, is generally considered to be high. however, co-existing disorders rather than the listeric infection itself seem to determine the outcome. in the present study of 72 listeric infections among non-pregnant adults, 28 patients without co-existing disease had a fatality rate of 10.7% as compared to 57.9% among 19 immunocompromised individuals. finally, in a third group of listeric patients, ...1979437892
resistance to listeria monocytogenes in mice: genetic control by genes that are not linked to the h-2 complex.after mice of several inbred strains were injected with listeria monoyctogenes, two parameters of resistance, the 50% lethal dose and the suppression of bacterial proliferation in spleen, were determined. the strains of mice tested could be segregated into two groups: the resistant c57bl/10sn mice and the sensitive a/j and dba/2j mice. congenic resistant strains of mice were used because they would express the h-2 haplotype of the sensitive strains (h-2a or h-2d) on the background of a resistant ...1979438535
[listeria monocytogenes meningitis. report of 12 cases (author's transl)]. 1979471725
fish oil-induced yellow fat disease in rats. iv. functional studies of the reticuloendothelial system.in rats with "stage s/e" yellow fat disease an injection of colloidal carbon resulted in a marked reduction in the number of circulating platelets. the death rate of rats with experimental listeria monocytogenes infection, the number of bacteria in their spleens and the decrease of bacteria in their spleens on the days after infection were the same in rats with yellow fat disease as in controls. the fact that the rats died during the first few days after infection also may indicate that their im ...1979473490
[determination of the bactericidal activity of peritoneal macrophages: a new method (author's transl)].a new method to estimate the bactericidal activity of peritoneal macrophages is described. this method allows to calculate with great accuracy the number of phagocytised bacteria per macrophage. in serial experiments different degrees of activation of macrophages in respect to their bactericidal activity against listeria monocytogenes has been shown.1979478579
[case of l. monocytogenes meningitis in the non-neonatal period].a case of listeria monocytogenes meningitidis in a little girl of envie (cuneo) is reported. the epidemiologic study has shown the presence of significatively high antibodies titers also in the sera of other members of the family.1979488580
listeria pneumonitis: influence of route of immunization on resistance to airborne infection.mice that are immunized with an airborne inoculum of bcg are more highly resistant to airborne challenge with mycobacterium tuberculosis than are mice that are immunized by the subcutaneous or intravenous route. to discover whether this phenomenon is peculiar to tuberculosis, we studied the influence of the route of immunization upon pulmonary resistance in listeria monocytogenes infection. mice were immunized by the airborne, intravenous, or footpad route and were subsequently challenged by the ...1979489125
mechanisms of listeria monocytogenes-mediated modulation of tumor growth.studies using listeria monocytogenes as an antitumor agent were initiated to determine the requirements for listeria-mediated tumor inhibition to occur. when strain 13 guinea pigs were injected with an admixture of viable listeria and a methylcholanthrene-induced fibrosarcoma in a ratio of 1 bacterium to 100 tumor cells, listeria had a marked capacity to inhibit tumor growth. this confirms an earlier study in our laboratory (m. m. dustoor, a. fulton, w. croft, and a. a. blazkovec, infect. immun. ...1979489127
cns listeriosis: rhomboencephalitis in a healthy, immunocompetent person.a previously healthy woman had a febrile illness resembling aseptic meningoencephalitis. with the exception of mild increase in both csf pressure and protein concentration, initial findings were normal, including negative bacterial cultures. bilateral pyramidal and cerebellar signs with multiple lower cranial nerve pareses developed over a 48-hour period beginning on the tenth hospital day. repeated blood and csf studies had previously been nondiagnostic, but at that time, cultures became positi ...1979508167
infection of the brainstem by listeria monocytogenes.a case of brainstem infection by listeria monocytogenes is described. the patient was a 63 year old man previously in good health and his illness did not follow the usual bi-phasic pattern. there was no prodromal phase, and the progressive brainstem signs with a lymphocytosis and a normal sugar level in the csf led to a tentative diagnosis of viral brainstem encephalitis. ampicillin was begun only when signs of pulmonary infection developed. clinical diagnosis is difficult but ampicillin should ...1979512667
simultaneous listeria monocytogenes septicaemia in mother and pre-term infant. 1979523369
mouse strain difference in the protection against listeria monocytogenes. 1979527919
evaluation of gentamicin and penicillin as a synergistic combination in experimental murine listeriosis.the administration of a combination of penicillin and gentamicin to mice given an intraperitoneal challenge of a highly pathogenic strain of listeria monocytogenes resulted in increased survival as compared with groups receiving penicillin alone or gentamicin alone or a control group that received no antibiotic. the median survival of animals that eventually died was no longer than in groups receiving single antibiotics and suggests that additional studies should be carried out to further invest ...1979533266
[bacterial meningitis in newborn infants. a retrospective study from a pediatric clinic 1967-1978].a total of 22 newborn infants (14 boys, 8 girls) have been admitted and treated for bacterial meningitis in the university pediatric service of geneva over a period of 11 years (may 1967 to may 1978). the three most common infectious agents were: group b beta-hemolytic streptococcus (6/22 cases), escherichia coli (6/22 cases), and listeria monocytogenes (4/22 cases). thirteen of the 22 infants died (a 59% mortality, in keeping with that observed in other centers). follow-up of the nine survivors ...1979541219
[infectious listeria monocytogenes endocarditis. apropos of a case]. 1979543809
anti-infective properties of vitamin a.1. six months after feeding a vitamin a free diet the liver content of mice was markedly reduced but not yet completely exhausted. these vitamin a deprived mice were either immunized with sheep erythrocytes or infected with listeria monocytogenes. in comparison to normal control mice no significant difference ws observed. this indicates that neither the immune system nor the mononuclear-phagocytic system was involved. 2. mice treated with a high dose of vitamin a showed increased antibody produc ...1979549269
[cellular antibacterial immunity (author's transl)].facultatively intracellular bacteria (mycobacteria, brucellae, listeria monocytogenes, salmonella typhi etc.) may not necessarily be killed after having being phagocytosed by polymorphonuclear leucocytes or macrophages, cellular immunity having first to be built up. this results in the formation of specifically committed t-lymphocytes, which in turn release lymphokines after restimulation by homologous antigen. under the effect of lymphokines, mononuclear phagocytes are chemotactically attracted ...1979551085
listeria monocytogenes. macroabscesses of placenta.macroabscesses of placenta caused by listeria monocytogenes were observed in a 37-year-old febrile primigravida. she was prematurely delivered of a depressed 2310-g infant, who was resuscitated and promptly treated with antibiotics. mother and child are well at 10-year followup. although perinatal listeriosis with placentitis is not rare, its presentation as macroabscesses of the placenta has until now gone unreported in the english language literature.1979760011
listeriosis. 19806103466
immunity to toxoplasma and listeria induced by homologous and heterologous organisms.cross protection of animals against various organisms have been shown for many years. this type of resistance to phylogenetically unrelated organisms might be attributed to certain immunological phenomena such as non-specific macrophage activation. in this report the cross-protective effect of some organisms against toxoplasma gondii rh strain and listeria monocytogenes is described. groups of mice were immunized with bcg, toxoplasma lysate antigen, viable cysts of t. gondii tehran strain and he ...19806104422
failure of synthetic muramyl dipeptide to increase antibacterial resistance.synthetic muranyl dipeptide, which potentiates antibody production and cellular immune responses at a dosage of 100 to 500 micrograms, did not enhance resistance to intravenous infection with a sublethal dose of 2 x 10(3) to 4 x 10(3) viable listeria monocytogenes cells in mice when intraperitoneally injected either 20 min or 5 days before infection. similarly, blockade of the mononuclear phagocyte system by dextran sulfate 500 could not be overcome by pretreatment with muramyl dipeptide. in con ...19806155329
stimulation of activated rat t cells in vitro by listeria monocytogenes antigens.a soluble extract of listeria monocytogenes bound firmly and in similar amounts to a variety of rat cells. cells that bound this material differed in their capacity to stimulate the in vitro proliferation of lymphocytes obtained from the thoracic duct of listeria-immune donors. the capacity of cells to serve as antigen-presenting cells in this system coincided or closely overlapped the expression on these cells of an ia antigen-like structure. three lines of evidence indicate that t cells respon ...19806159325
systemic candidiasis in mice. ii.--main role of polymorphonuclear leukocytes in resistance to infection.cyclophosphamide (cy) increased whereas the talc embedded in a calcium phosphate gel (tcp) decreased the susceptibility of mice to systemic candidiasis estimated by measuring mean survival time and "renal infectivity" 12 h after challenge. transfers of plasma from cy- and tcp-treated mice did not modify cnadidiasis susceptibility of recipient mice. granulopenia and granulocytosis induced respectively by cy and tcp were significantly correlated with susceptibility or resistance to candidiasis. ne ...19806249181
[electron microscopic findings on reversion of listeria l-forms].reversion in l-forms of listeria monocytogenes was studied with the use of electron microscopy. in the culture undergoing the process of reversion cells differing in size, form and the electron density of the cytoplasm were present. the process of reversion was characterized by the increase of cytoplasmic density, the decrease of nucleoid, the appearance of fibrillary material of medium electron density on the membrane surface and the longitudinal elongation of the cell. the cell wall of the rev ...19806251676
comparative effects of an inflammatory reaction on the resistance of mice to bacterial and viral infections.the induction in mice of a sterile subcutaneous granuloma exerted no influence upon the mortality following their infection with herpes type 1, murine hepatitis or encephalomyocarditis viruses. attempts to reproduce the resistance -- which has been found to occur as a result of the granulomatous reaction, in the case of bacterial, fungal or protozoa infections and tumour invasions -- by varying the route and timing of the virus inoculation or the strain of mice have failed. we conclude that it i ...19806251747
chemiluminescence by listeria monocytogenes.listeria monocytogenes cells suspended in brain heart infusion broth or in carbonated saline solution emitted light (chemiluminescence) that could be detected by a liquid scintillation spectrometer. this chemiluminescence was inhibited by superoxide dismutase and catalase but not by the hydroxyl radical scavengers mannitol and benzoate; it was also dependent upon and proportional to the carbonate ion concentration in the medium. organisms suspended in carbonated saline solution which had ceased ...19806253442
effect of influenza virus infection on susceptibility to bacteria in mice.a model of combined infection was established with intranasal influenza virus and systemic listeria monocytogenes infections of mice. prior infection of mice with influenza virus markedly influenced resistance to subsequent challenge with l. monocytogenes. if mice were infected with influenza virus within the 24-hr period before challenge, a substantial increase in mortality was reflected by enhanced growth of listeria in the spleen. if mice were infected with influenza virus three or five days ...19806257797
splenic regulation of cell-mediated immunity to listeria monocytogenes.splenectomized mice are more resistant than normal mice to infection by listeria monocytogenes. the nature of splenic regulation of cell mediated immunity to listeria was investigated. splenectomized mice were reconstituted with normal syngeneic spleen cells and normal plasma from listeria-stimulated normal donors to determine if suppression of resistance in normal mice was cellular or humoral. mice receiving spleen cells showed no decreased resistance, but mice receiving plasma showed decreased ...19806448219
comparison of in vitro activity of moxalactam (ly127935) with cefazolin, amikacin, tobramycin, carbenicillin, piperacillin, and ticarcillin against 420 blood culture isolates.to compare the in vitro activity of moxalactam (ly127935), a new broad-spectrum antimicrobial agent, with cefazolin, amikacin, tobramycin, carbenicillin, piperacillin, and ticarcillin, each drug was tested against 420 bacterial isolates from the blood of septic patients. standard broth dilution methods were used to determine minimum inhibitory and bactericidal concentrations. ly127935 was as active as the aminoglycosides against aerobic gram-negative organisms, including pseudomonas aeruginosa, ...19806448577
[studies on the increased susceptibility to infections in streptozotocin-induced diabetic mice. altered resistance against listeria monocytogenes and pseudomonas aeruginosa infection (author's transl)]. 19806450149
macrophage activation during experimental murine brucellosis. iii. do macrophages exert feedback control during brucellosis? 19806766089
on the mechanism of t cell-independent anti-listeria resistance in nude mice. 19806766161
resistance to listeriosis in mice that are deficient in the fifth component of complement.infection with listeria monocytogenes was studied in strains of mice with genetic absence of the fifth component of complement (c5). mice deficient in c5 consistently showed an increased growth of listeria in their spleens as compared to normal mice. this increased growth was not corrected by administration of plasma containing c5. furthermore, depletion of c5 and terminal complement components by administration of cobra venom factor did not impair the resistance to listeria infection of normal ...19806766905
regulation of macrophage populations. i. preferential induction of ia-rich peritoneal exudates by immunologic stimuli.the amounts of ia-positive and -negative macrophages were studied in peritoneal exudates of normal mice or of mice injected with various inflammatory materials, infected with listeria monocytogenes, or injected with hemocyanin. ia-negative macrophages predominated in exudates from normal mice or from mice given mineral oil, peptone, thioglycollate, culture media, or endotoxin. infection with listeria caused a very marked increase in ia-positive macrophages. the induction of ia-positive macrophag ...19806766974
a murine model for listerial meningitis and meningoencephalomyelitis: therapeutic evaluation of drugs in mice.meningitis and meningoencephalomyelitis caused by listeria monocytogenes were experimentally established in mice. the pathological changes in brain and spinal cord resulting from the infection resemble those observed in man and domestic animals. the efficacy of 24 antibiotics in treating this experimental infection was determined. minocycline and chlortetracycline were the most efficacious antiotics followed by amoxicillin, which was 2- to 4-fold less active than the former. however, the acute t ...19806767585
decreased resistance to listeria monocytogenes in mice injected with killed corynebacterium parvum: association with suppression of cell-mediated immunity.to investigate the therapeutic potential of killed corynebacterium parvum, its effects on the course of listeria monocytogenes infection in mice was studied. mortality in mice given c. parvum after l. monocytogenes infection was greater than in mice given c. parvum before infection or infected with only l. monocytogenes. c. parvum alone resulted in no mortality. spleens from infected mice given c. parvum had increased numbers of l. monocytogenes. peritoneal macrophages from mice infected with on ...19806767792
physicochemical characteristics of listeria specific antigen 2.listeria specific antigen 2 (ag2) was purified to within 97% of homogeneity, with a high yield, using both gel filtration and polyacrylamide gel electrophoresis. ag2 is a glycoprotein. its isoelectric point is about 4.2. as determined by sodium dodecyl sulphate-polyacrylamid gel electrophoresis, its molecular weight in 16710 +/- 450. ag2 may aggregate easily since it was previously found in gel filtration in a peak corresponding to a molecular weight of 160000. no enzyme activity has been found ...19806768841
relation between bactericidal and phagocytic activities of peritoneal macrophages induced by irritants. 19806768886
monocyte function in rheumatoid arthritis.monocytes derived from peripheral blood of patients with rheumatoid arthritis (ra) had a marked defect in their bactericidal activity against staphylococcus albus and listeria monocytogenes; whereas the phagocytic capacity of monocytes from ra patients for both staph. albus and shigella flexneri was similar to that of monocytes from healthy subjects. there were no significant differences between the patient and control groups with regard to antibody dependent cellular cytotoxicity (adcc) of mono ...19806769149
[a spate of listeriosis in newborn infants in vienna (author's transl)].twelve years after the last bacteriologically verified case of human listeriosis was reported in austria, 3 cases of neonatal listeriosis have been observed in vienna within the space of a few months. in 2 patients the disease was definitely septicaemic, whilst the third suffered from predominantly pneumonic manifestations. as the clinical picture is not uniform, neonatal listeriosis may be difficult to recognize. therefore, the consulted physician ought always to consider this disease, when he ...19806769258
thioglycolate medium decreases resistance to bacterial infection in mice.brewer thioglycolate medium, a bacterial culture medium which is widely used as a nonspecific in vivo macrophage stimulant, was tested for its effect on mouse resistance to bacterial infection. mice which did or did not receive thioglycolate medium were challenged with listeria monocytogenes. injection of thioglycolate medium significantly decreased the ability of the host to resist infection. this decreased resistance occurred whether thioglycolate medium was injected 0 to 9 days before, or 1 t ...19806769800
pseudomonas aeruginosa infection and vaccination in the rat.a large molecular-weight fraction of pseudomonas aeruginosa culture filtrate protected rats and mice against a lethal infection with a heterologous serotype, and to some extent against escherichia coli and listeria monocytogenes. the active components were obtained from cultures grown for several days in a simple synthetic medium. infection and vaccination with p. aeruginosa serotype 16 induced agglutinating and precipitating antibodies to the components of this serotype only; in rats infected o ...19806770090
[meningoencephalitis listeriosa]. 19806770320
listeriosis in sheep. isolation of listeria monocytogenes from organs of slaughtered animals and dead animals submitted for post-mortem examination. 19806770617
macrophage function in germ-free, athymic (nu/nu), and conventional-flora (nu/+) mice. 19806771397
listeriosis in adults: a changing pattern. report of eight cases and review of the literature, 1968-1978. 19806771866
[isolation of l-forms of bacteria from mixed microbial populations by ultracentrifugation]. 19806771943
macrophage activation and resistance to pulmonary tuberculosis.mice were vaccinated with 300 micrograms of bcg cell walls (bcg-cw) in oil-in-water emulsion intravenously or with a high or low dose of living bcg by inhalation (bcg-hd or bcg-ld, respectively). the consequences of vaccination were evaluated in terms of the growth of bcg in the lungs and spleen, lung and spleen weight, resistance to intravenous and airborne challenge with listeria monocytogenes, airborne challenge with virulent mycobacterium tuberculosis h37rv, and transfer of adoptive immunity ...19806772560
cell-mediated immunity to intestinal infection.specified pathogen-free b6d2f1 mice were orally infected with various doses of listeria monocytogenes. oral inocula containing more than 2.5 x 10(8) live organisms consistently initiated infection in the peyer's patches (pp) of the small intestine. at lower doses the infection was sporadic, with many mice showing no apparent infection in the pp. the pp appeared to be the only site of tissue invasion and l. monocytogenes survival in the intestinal tissues, as no organisms were recovered from muco ...19806772561
enhancement of resistance to infections by endotoxin-induced serum factor from mycobacterium bovis bcg-infected mice.necrosis of a variety of transplanted murine tumors can be induced by serum from mycobacterium bovis bcg-treated mice challenged with a lethal dose of endotoxin. results reported here show that the tumor necrosis serum (tns) enhances resistance to infections, protecting mice against two types of challenges, either with klebsiella pneumoniae or with the intracellular parasite listeria monocytogenes. moreover, tns activity was demonstrated in animals which are refractory to lipopolysaccharide and ...19806772564
acute starvation protects mice against listeria monocytogenes.we investigated the effect of starvation on the course of listeria monocytogenes infections in mice. mice starved for 24, 48, or 72 h and then inoculated with a lethal dose of l. monocytogenes showed significantly less mortality than mice not starved (i.e., fed mice). the protective effect of 48 or 72 h of starvation began immediately after the starvation period and persisted for at least 48 h. starved, infected mice had significantly fewer l. monocytogenes cells in their spleens 2, 3, and 4 day ...19806772566
expression of antibacterial resistance at the site of a delayed hypersensitivity reaction.the site of a delayed hypersensitivity reaction to tuberculin or bovine serum ablumin was shown to contain mechanisms that expressed increased antibacterial activity, as evidenced by restricted growth of a local inoculum of listeria monocytogenes. as was the case with a delayed hypersensitivity reaction, the local generation of antibacterial activity was antigen specific and t-cell dependent. antibacterial resistance was always expressed at the site of injection of specific antigen in sensitized ...19806772576
metabolism of purines in macrophages. effect of functional state of the cells.ecto-5'-nucleotidase is known to be diminished markedly in activated compared to control mouse macrophages. the level of three purine nucleoside metabolizing enzymes, adenosine deaminase (ec 3.5.4.4), purine nucleoside phosphorylase (ec 2.4.2.1), and adenine phosphoribosyltransferase (ec 2.4.2.7) were measured in the sonicates of different populations of mouse peritoneal macrophages. levels of adenine phosphoribosyltransferase and purine nucleoside phosphorylase in macrophages that were elicited ...19806772733
[ventriculitis caused by listeria monocytogenes].a case of meningitis due to listeria monocytogenes is reported. the bacteria was mainly located in brain ventricles and induced ventriculitis. the patient is clinically and bacteriologically analyzed. the greenish-yellow color of spinal fluid resembling the pigmentation of amniotic fluid by listeria monocytogenes is stressed.19806773117
the role of divalent cations in interactions between lymphokines and macrophages. 19806773670
genetically determined differences in antibacterial activity of macrophages are expressed in the environment in which the macrophage precursors mature. 19806773671
[clinical differentiation between idiopathic respiratory distress, neonatal septicemia caused by group b streptococci and septicemia caused by other pathogens (author's transl)].since bacterial infection in newborns must be treated as specifically and as early as possible, it is important to confirm a diagnosis of suspected infection based on clinical symptoms and to take possible pathogens into consideration when choosing therapy. rds and septicemia with group b streptococci can present very similar clinical symptoms, but leucopenia on the first day of life is most probably an indication of septicemia with group b streptococci. septicemia caused by other pathogens, how ...19806773886
phenol-extracted lipopeptidopoly-saccharide (lpps) complex from listeria monocytogenes.endotoxin phenol extraction method with subsequent ultracentrifugation and/or chromatographic analysis on sepharose 2 b column were used to obtain biologically active isolate that turned out to contain polysaccharide, peptide and lipid fractions. the raw phenol extract formed 15% and the lpps complex, obtained from it by ultracentrifugation, 0.17% of bacterial biomass. the lpps complex contained 11 amino acids representing about 11% of its dry weight. similarly as in factor ei and in analogous e ...19806774009
allogeneic restriction in the rat: genetic basis of restriction of the t cell mediators of delayed-type hypersensitivity and antimicrobial resistance to listeria monocytogenes.the genetic basis of the restriction imposed on t cell mediating acquired antimicrobial resistance and delayed-type hypersensitivity (dth) to listeria in the rat was investigated. sharing of mhc-coded genes between donors of sensitized t cells and antigen-stimulated recipients was both necessary and sufficient for efficient transfer of both resistance and dth. evidence to support this assumption was derived from experiments involving allogeneic transfers within major histocompatibility complex ( ...19806774028
suppression of bactericidal activity of macrophages in ascites tumors. 19806774094
killed listeria monocytogenes vaccine is protective in c3h/hej mice without addition of adjuvants. 19806774260
biological properties of l-forms and their parent bacteria.l-forms of staphylococcus aureus, streptococcus faecalis, listeria monocytogenes and salmonella typhy and their parent bacteria were examined for biological properties and compared with their parental forms. some l-forms differed from their parent bacteria and required a longer incubation period.19806774598
electron microscopic observations on the interaction of listeria monocytogenes and peritoneal macrophages of normal mice.acid phosphatase histochemistry was performed to study ultrastructurally the intracellular survival and digestion of listeria monocytogenes in normal mouse peritoneal macrophages. acid phosphatase activity proved to be a useful marker for digestive processes of the macrophages, as this activity could be seen in the cytoplasm of killed listeria before disintegration, but not in viable listeria. almost all killed listeria and the majority of the viable listeria were found in phagosomes of the loos ...19806775151
a simple method for the isolation of phages from listeria monocytogenes.by application of a combined mitomycin-/heat treatment after freezing, 7 out of 29 listeria monocytogenes strains which were found to be non-phage carriers by uv irradiation could release phages. propagation of the obtained phages was promoted by storage at 4 degrees c. apart from tnsa plates the application of chocolate plates appears to be necessary in order to study these phages.19806775437
primary immune response of mice to sheep erythrocytes during the course of infection with listeria monocytogenes.the influence of an infection with a sublethal dose of viable listeria monocytogenes on the primary antibody-forming potential of mice against sheep erythrocytes (se) was monitored by means of counting plaque-forming cells (pfc) in the spleen and measuring circulating antibodies against se. additionally, the course of infection was followed by determination of viable bacteria in the spleen. as against the injection of killed l. monocytogenes, infection with viable bacteria did not display any si ...19806775440
listeriosis in humans and animals in the netherlands (1958-1977).during the past twenty years 793 strains of listeria monocytogenes were isolated from human beings in the netherlands; of these 193 were taken from neonates and babies up to two months old. isolations from adults came from patients (242) as well as clinically healthy people (358). septicaemia appeared to occur to an equal extent in men and women (20 and 29 respectively), whereas meningitis was found more often in men than in women (50 and 22 respectively). a clear predisposition for l.m. develop ...19806775441
survival of listeria monocytogenes in high salt concentrations.the bactericidal effects of high concentrations of common salt has been determined in a laboratory medium for listeria monocytogenes strain (1, 2a, no. 18). the survival time for the organism was followed at three different incubation temperatures (4, 22, 37 degrees c). the influence of temperature on the action of salt is discussed.19806775446
immunotherapy of the guinea pig line 10 hepatocarcinoma with a variety of nonviable bacteria.a variety of heat-killed bacteria were tested for their capacity to induce regressions of established line 10 hepatocarcinomas in syngeneic guinea pigs. multiple intralesional injections of heat-killed escherichia coli, streptococcus mutans, listeria monocytogenes, and propionibacterium acnes resulted in complete regression of the tumor in a majority of guinea pigs. repeated injections of heat-killed mycobacterium bovis strain bacillus calmette-guérin caused no regressions. surviving animals wer ...19806775802
relationship between non-specific activity of macrophages and immune responses to listeria monocytogenes.delayed footpad reactions and acquired cellular resistance to listeria monocytogenes were studied in mice whose mononuclear phagocyte system (mps) had been blocked or stimulated. colloidal carbon was used for the blockade of mps and corynebacterium parvum used for the stimulation. strong delayed footpad reactions. on the other hand, the i.v. injection of 3 x 10(1) listeria induced an appreciable level mice, while in mps-stimulated mice, i.v. injection with even 4 x 10(3) listeria could not induc ...19806776031
interaction of nonhuman primate peripheral blood leukocytes and coccidioides immitis in vitro.the leukocytes from rhesus macaques could not kill either endospores or arthrospores of coccidioides immitis even in the presence of immune serum and complement, although these leukocytes were able to kill candida and listeria organisms.19806776061
obstetrical management of maternal listeremia.a case is reported of fetal survival after maternal listeremia. transplacental fetal infection may have been prevented by early delivery. review of the literature suggests that management be based on cultures of the maternal and fetal compartments. we believe that the considerations for immediate delivery as opposed to medical therapy should rest on the fetal maturity and the sensitivity of the organism to antibiotics which will reach therapeutic levels in the fetal compartment.19806777134
enhanced elimination of listeria monocytogenes at the site of delayed footpad reaction.the protective activity against a challenge infection with listeria monocytogenes was investigated at the site of a delayed footpad reaction in mice immunized with viable or killed listeria. delayed footpad reactivity was induced only in mice immunized with viable bacteria. rapid and marked elimination of challenge bacteria was observed only at the site of reaction in mice immunized with viable bacteria but not in mice immunized with killed bacteria. macrophage migration inhibitory activity was ...19806777299
mechanism of cellular suppression induced by oral tilorone treatment of mice.specific-pathogen-free b6d2 f1 hybrid mice were treated orally with tilorone hydrochloride (100 mg/kg of body weight per day) and infected with sublethal doses of listeria monocytogenes, salmonella enteritidis, mycobacterium bovis (bcg pasteur), or m. tuberculosis erdman. daily tilorone treatment inhibited the cell-mediated response to all of the intracellular parasites, and most of the mice succumbed to the challenge. tilorone suppressed delayed hypersensitivity responses to the microbial sensi ...19806777302
effects of human neutrophils and monocytes on nocardia asteroides: failure of killing despite occurrence of the oxidative metabolic burst.to study mechanisms of resistance to nocardia asteroides in vitro, suspensions of human neutrophils and monocytes were challenged with n. asteroides in the presence of autologous serum. at 4 hr, numbers of viable n. asteroides incubated with neutrophils and monocytes averaged only 10% and 21% less, respectively, than numbers of n. asteroides incubated without phagocytes. in contrast, a mean of > 90% of listeria monocytogenes and staphylococcus aureus incubated with neutrophils and monocytes was ...19806777435
the effects of iron and temperature on the growth of listeria monocytogenes in cell-free media.the effects of variable iron and temperature on the growth of l. monocytogenes in vitro was investigated in cell-free tissue culture medium 199. two temperatures, 37 degrees and 42 degrees c, and varying concentrations of iron (fe+3) derived from ferric ammonium citrate, 40--130 microgram/ml, were selected for the study. under these conditions, l. monocytogenes exhibited better growth at 37 degrees c than at 42 degrees c. dose-effect was demonstrated at every succeeding higher fe+3 concentration ...19806777652
effect of listeria monocytogenes lipids on the immunity of mice against candida albicans, cryptococcus neoformans and trichomonas vaginalis.the effect of listeria monocytogenes lipids (lm lipids) on immunity against candida albicans, cryptococcus neoformans and trichomonas vaginalis was studied in mice. the administration of lm lipids did not affect significantly the course of t. vaginalis infection. on the other hand, single lm lipids injection markedly decreased the mortality rate of mice with mycotic infections, and significantly accelerated the elimination of fungal cells from liver, spleen and blood circulation of animals. it i ...19806778451
listeria monocytogenes infection in bovine mastitis.listeria monocytogenes type 4 was isolated from milk of a cow affected with mastitis in the left fore quarter. histological examination revealed a severe suppurative mastitis with eosinophil leucocytes predominating among the inflammatory cells. the findings and the public health aspect of the condition are discussed.19806779410
humoral and cellular immune response in mice after infection with salmonella typhimurium.nmri mice were infected orally with s. typhimurium. specific antibody titers determined by indirect hemagglutination, and cellular immune response tested by blastogenesis transformation of lymphocytes and enhanced bactericidal action on listeria monocytogenes were studied in relation to persistence of bacteria up to one year after the infection. about three weeks after the infection cell mediated immune reactions were no longer detected and in the course of a year detection of serum antibodies o ...19806779438
experimental infection of mice with listeria monocytogenes and l. innocua.swiss mice were infected with two listeria strains: l. monocytogenes strain 10401, serovar 4b, and l. innocua strain 390, serovar 6a. bacteria were inoculated by intravenous, subcutaneous or oral routes, and then enumerated in the spleen. the splenic infection was studied comparatively for these three inoculation routes with both strains. strain 390 caused a splenic colonization only after intravenous inoculation. for the 10401 strain, the peak of infection appeared on the 3rd day after inoculat ...19806779690
the effect of listeria monocytogenesis lipids on the mouse lymphocytes in vitro.the effect of listeria monocytogenes lipids (lml) on the incorporation of 3h-thymidine into mouse spleen lymphocytes cultured in vitro was studied. it has been found that lml was mitogenic for b lymphocytes but did not stimulate t lymphocytes. the presence of autologous t dependent cells did not change the intensity of b lymphocytes stimulation of lml. however, macrophages markedly increased the effect of lml on b lymphocytes. the supernatants of the cultures of unfractionated spleen lymphocytes ...19806779774
the effect of listeria monocytogenes lipids on the activity of nonspecific immune mechanisms.the administration of listeria monocytogenes lipids (lml) in mice resulted in the development of population of macrophages with increased phagocytic and microbicidal activity, as well as higher content of the lysosomal acid hydrolases. the elevation of the serum level of lysozyme, complement and properdin in guinea pigs after lml injection was observed. the normal macrophages cultured in vitro were also activated by lml independently on the presence or absence of autologous lymphocyte. it is con ...19806779775
the effect of adult exposure to diethylstilbestrol in the mouse: alterations in tumor susceptibility and host resistance parameters. 19806780687
[serological diagnosis of listeria infections. optimal conditions for conduction of the hemagglutination test]. 19806780742
[characteristics of microbial multiplication in parenterally infected xenopsylla cheopis (siphonaptera) fleas].being inoculated parenterally various microbes cause the fleas x. cheopis a stable infection which, as a rule, is preserved in experimental insects to the end of life. reproducing intensively listeria monocytogenes and salmonella typhimurium caused the death of all ectoparasites in 3 to 5 days. the increase in abundance of escherichia coli, yersinia pseudotuberculosis, y. enterocolitica and vaccine strains of y. pestis "ev" and francisella tularensis went on gradually and infected fleas lived up ...19806780964
[bacteriostatic and bactericidal effect of penicillins, cephalosporins, aminoglycosides and ampicillin plus gentamicin compared to trimethoprim plus sulfamethoxazole on "listeria monocytogenes" (author's transl)].the bacteriostatic effect of penicillins and old and new cephalosporins was studied on ten strains of listeria monocytogenes. their bactericidal effects were studied in relation to time and concentration of antibiotics. if the betalactamines are bactericidal after 48 h only, they can be distinguished by their mbc/mic ratio. cephalosporins have a smaller ratio (8 to 32/200) than penicillin and ampicillin; the new cephalosporins have not improved the bactericidal effect of the oldest. the associat ...19806781393
[listeria monocytogenes action on viral t8 epithelioma growth].effects of listeria monocytogenes on normal and tumor-bearing rats were evaluated. inhibition of t8 tumor and its metastases in tumor-bearing rats treated with l. monocytogenes was observed. macrophage phagocyte functions, depressed in tumor bearing rats, was restored by l., monocytogenes. in particular, a dissociation between different macrophages functions in tumor-bearing rats was observed.19806781505
[effect of phospholipid fractions from various bacteria and fungi on the immunity of mice to bacterial infections]. 19806782398
candidacidal activity of mouse macrophages in vitro.mouse peritoneal macrophages were infected in vitro with candida albicans, and the phagocytic and candidacidal activities were estimated by microscopic examination of giemsa-stained cells. activated macrophages obtained from either bcg-vaccinated animals or by in vitro exposure of normal macrophages to phytohemagglutinin-induced lymphokines exhibited higher phagocytic and candidacidal activities than did normal macrophages. however, activated macrophages obtained by in vitro exposure of macropha ...19806783531
the influence of intrauterine infection on the brain of rabbit foetus. 19806787837
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