Publications

mineralization of the enamel of ovine permanent central incisor teeth using microhardness and histological techniques.		1979	116728
study of the anti-tumor effect of polypeptide pineal extract.	bovine pineal polypeptide extract (ppe) exerted an anti-tumor effect on mouse-transplantable tumors: mammary cancer (rsm), squamous cell cervical carcinoma (scc), hepatoma-22a and lympholeukemia lio-1, and had no effect on harding-passey melanoma and leukemia l-1210. it was shown that ppe possessed the ability to decrease the incidence of dmba-induced mammary adenocarcinomas in rats. the daily administration of 0.5 mg ppe prolonged the life span of rats by 25% and failed to influence spontaneous ...	1979	117414
nitroblue tetrazolium (nbt) reduction by bacteria. some properties of the reaction and its possible use.	all the s. albus, e. coli and p. aeruginosa strains examined reduced nitroblue tetrazolium (nbt) to dark blue formazan. the amount of formazan produced was proportional to the number of bacteria. under the same growth conditions, an equal number of bacteria of various strains produced different amounts of formazan. however, there were statistically verified differences in the nbt-reduction between the three species examined. the nbt-reduction took place in all phases of growth but was most inten ...	1979	115226
putreanine in developing monkey brain: relation to polyamines.		1979	115966
restriction cleavage map of sp01 dna: general location of early, middle, and late genes.	a detailed restriction endonuclease map for the genome of bacillus subtilis phage sp01 is presented. sites of cleavage for the restriction enzymes bglii, ecori, haeiii, and sali were determined. this physical map showed that sp01 dna was 140 kilobases in length and contained a repeated sequence of 12.4 kilobases at its termini. combined with previously published information, we were also able to identify the general locations of genes expressed at early, middle, or late times in the phage lytic ...	1979	116010
the etiology of acute pelvic inflammatory disease.		1979	116376
[animal experiments on the biomechanical vibration behaviour of the bulbus (author's transl)].	mechanical vibration may have a detrimental effect on visual performance. this particularly seems to be the case if the natural frequency of the bulbus is excited. experiments with animals were made with the aim of calculating the biomechanic transmission of vibration between the cranium and bulbus. postmortem experiments using pig crania have shown that in vivo application of the method of sewing miniature accelerometers onto the cornea may be possible. our experiments with monkeys gave typical ...	1979	116566
[a vector system designed to allow excretion of a protein encoded by a cloned gene].	we describe a method which should allow construction of bacterial strains able to export a given protein through the cytoplasmic membrane. the principle is to fuse the structural gene of the protein to the proximal part of gene lamb, the structural gene of the lambda receptor, an outer membrane protein of e. coli k-12.	1979	111853
pharmacokinetics in the interpretation of chronic toxicity tests: the last-in, first-out phenomenon.		1979	112717
three types of mycolic acid from mycobacterium tuberculosis brévanne: implications for structure-function relationships in pathogenesis.	saponification of the chloroform-soluble wax from mycobacterium tuberculosis brévanne led to the isolation of three classes of mycolic acid containing characteristic functional groups along the methylene backbone: type alpha (two cyclopropane rings); type beta (methoxyl, methyl, and cyclopropane); and type gamma (ketone, methyl, and cyclopropane). the structures of these acids were elucidated principally by mass spectrometry. the high mass region of the keto mycolate is presented showing the mer ...	1979	110779
experimental acute salpingitis in grivet monkeys provoked by chlamydia trachomatis.	chlamydia trachomatis is a common cause of sexually transmitted diseases. recently it has been shown that chlamydiae are also responsible for complications to such lower genital tract infections. in this study, isolates of c. trachomatis from the fallopian tubes of patients with acute salpingitis were inoculated direct into the fallopian tubes of two, and through the cervical canal into the uterine cavity of one grivet monkey. the experimental infections resulted in a self-limited acute salpingi ...	1979	107723
alcohol-induced pituitary adenolysis: how does it control intractable cancer pain?--an experimental study using tooth pulp-evoked potentials in rhesus monkeys.		1979	110174
isolation and cell culture propagation of rotaviruses from turkeys and chickens.	rotaviruses were detected by electron microscopy in the faeces of turkey poults and broiler chickens with diarrhoea. apparently symptomless infection was also observed in broilers. the avian rotaviruses could not be isolated in cell cultures by conventional techniques, but were adapted to serial growth in chick cell cultures following trypsin treatment of the virus and the cells. immunofluorescence studies showed that the avian and mammalian rotaviruses are antigenically related. antibodies to r ...	1979	92979
delayed hypersensitivity to chlamydia trachomatis: cause of chronic prostatitis.		1979	93221
a presumed intron of the mitochondrial mosaic gene controlling cytochrome b in saccharomyces cerevisiae contains a diuron-resistant genetic locus [proceedings].		1979	93452
[why monospecific tuberculin skin test antigens have not been isolated].		1979	93497
recent advances in applied malaria immunology.	our present knowledge of cellular and humoral factors which are involved in immunity to plasmodial infections are discussed. immunization against plasmodial infection has been achieved in birds, rodents, simians, and humans. avian hosts have been immunized against gametocytes which resulted in inhibition of gametocytes within the mosquito vector. immunization of humans against plasmodial gametocytes would indirectly protect them against malaria by blocking mosquito transmission to other suscepti ...	1979	93828
a comparative study in porcellio laevis (lat.) and armadillidium vulgare (lat.): response to temperature, photoperiod and oxygen concentration.	relationship of body weight, imposed fasting, temperature, light intensity, and oxygen concentration to oxygen consumption in porcellio laevis and armadillidium vulgare has been investigated in a series of laboratory experiments. it was observed that (1) the metabolic response in the two species to temperature change was a uniform increase of oxygen consumption with increasing temperature from 15 degrees c to 60 degrees c. beyond 30 degrees c, the oxygen consumption in each species fell, and the ...	1979	93887
[deoxyribonucleic acids from pasteurella multocida and pasteurella haemolytica].	pasteurella multocida and p. haemolytica strains contain between 1.5 and three per cent phosphorus, between nine and 14 per cent nitrogen, between two and four per cent dna, and between five and 18 per cent rna, the precise figures depending on culturing conditions. high-molecular dna may be isolated by means of bacteriolysis, using deoxycholate or dodecylsulphate and the usual steps of purification, with yield and purity differing by strains. dna with sufficient purity can be obtained from seph ...	1979	93955
update: drugs in breast milk.	drugs found in a woman's blood can be detected in her milk. the concentration in milk depends on the amount of drug in maternal blood, its lipid solubility and degree of ionization, whether it is actively secreted into the milk, and status of maternal renal function. alcohol concentration in the mother's milk is generally about equal to that in her blood; it is not known however, how large a daily dose can be tolerated by an infant. anticoagulants may or may not appear in breast milk. no sig ...	1979	84332
effects of etafenone and antiarrhythmic drugs on na and ca channels of guinea pig atrial muscle.	since ca-mediated electrophysiological phenomena seem to be important in the generation of various arrhythmias, we quantitatively compared the effects of quinidine, disopyramide, procainamide, lidocaine, propranolol, and etafenone, a new coronary vasodilator with antiarrhythmic properties, on na and ca channels in normal and depolarized guinea pig atria. the maximum rate of rise of the normal action potential and the amplitude of the depolarized, ca-mediated action potential were measured to exa ...	1979	94412
hereditary alpha 2-macroglobulin deficiency.	on screening of a normal material 1 man was found (age 37) who on repeated determinations had a low alpha 2m, namely 25 % with electroimmuno assay according to laurell. investigation of the family revealed that the mother (age 69) and one daughter (age 5) had low values too. all other coagulation and fibrinolytic components were normal. they had no signs of increased fibrinolysis and normal levels of alpha 2-antiplasmin, alpha 1-antitrypsin and antithrombin iii. liver function tests were normal. ...	1979	94459
enzymatic activity and qualitative immunochemical analysis of human dental plaque.		1979	94565
localization of concanavalin a binding sites with a concanavalin a-alkaline phosphatase method.		1979	94665
false negative hla-dr assignment necrokidney donors. a glucocorticoid effect?	thirteen potential necrokidney donors were hla-dr typed using peripheral blood b lymphocytes (pbbl). antigen assignment was impossible in 10 cases because of non-reactivity of the pbbl with the hla-dr testserum set, in some of the cases in spite of positive reactions with a positive control xenogeneic anti-human b cell antiserum. in five of these 10 donors, hla-dr typing was also performed on b lymphocytes isolated from the spleens, and in all five cases strong specific reactions were obtained, ...	1979	94708
transferable drug resistance of escherichia coli isolated from infant diarrhoea.	the resistance to several drugs was determined in 29 pathogenic strains of escherichia coli (026, 055 and 0111) isolated from infant diarrhoea and 18 non-pathogenic e. coli strains isolated from the same individuals. both pathogenic and nonpathogenic strains were resistant to at least 1 to 10 drugs, but only in four cases resistance patterns of the pathogenic strains were identical with those of non pathogenic ones. the majority of the strains were resistant to sulfonamide, tetracycline, ampicil ...	1979	94745
early detection of chlamydia trachomatis using fluorescent, dna binding dyes.	hela 229 cells were infected with genital tract strains of chlamydia trachomatis. after incubation for varying times the infected cells were fixed and stained with the fluorescent dna binding dyes hoechst 33258 or dapi for comparison with conventional giemsa stain. fluorochrome-treated preparations were examined by incident ultraviolet fluorescence microscopy and the giemsa-stained preparations by dark-ground light microscopy. chlamydial inclusion bodies could be identified unambiguously as earl ...	1979	92480
[identification of nerve cells in the visual cortex of the rat using nissl and golgi-kopsch methods].	the neurons of the visual cortex of the albino rat were studied using both the nissl- and golgi-kopsch methods. in nissl preparations we can distinguish between a group of neurons rich in cytoplasm, a group of neurons poor in cytoplasm and an intermediate group. in the golgi preparations the neurons can be subdivided according to the shape of their cell bodies, dendrites and axons. spiny cells with long axonal main trunks are pyramidal cells, multiangular cells and stellate cells of layer iv. ce ...	1979	94077
[immunosuppressive activity of variously prepared alpha-globulin fractions of human blood].		1979	94844
[retrospective study in hepatic biopsies, of hepatitis b surface antigen by the orcein method and indirect immunofluorescence methods].	a retrospective study of the hbsag was done in 56 liver biopsies of children less than 12 year-old and 78 biopsies of adults. the study was performed by orcein stain and indirect immunofluorescent method. in 23 of the adults patients, the serological detection of hbsag and antibodies (hbsab) was determined by reverse passive haemagglutination technique. the adults patients' histological dianosis were variable and included acute or chronic hepatitis (20.5%) and cirrhosis (24.4%). orcein was posit ...	1979	95161
e-type delayed fluorescence depolarization, technique to probe rotational motion in the microsecond range.	e (eosin)-type delayed fluorescence depolarization studies extend the time range for the measurement of rotational diffusion to microseconds and ms, thereby allowing investigation of slow rotational movement of macromolecules like membrane proteins. an apparatus is described for the determination of time-dependent anisotropy in this interesting time range. the method has been tested on eosin-labelled cytochrome p-450 incorporated into phospholipid membrane vesicles.	1979	95189
[general considerations on the interferon system].	in this review some interesting aspects of interferon and its present perspectives for a practical utilization in human viral infections and in oncological therapy are described. after an evaluation of general characteristics of if, some particular problems are considered about this system as that of if and poly i:c interaction with cellular membranes, genetic control of if system, if and its inducers influence on immune reactivity and human tumours cells if inducing ability and sensitivity. fin ...	1979	95450
the use and possible misuse of tetracycline as a vital stain.		1979	95888
diisopropylfluorophosphate-evoked inhibition of anaphylactic histamine release from human skin: decrease of the inhibition by storing the skin specimens.	antigen-induced histamine release from human skin slices passively sensitized with reaginic serum in vitro was inhibited by dfp, suggesting involvement of serine esterase activation in the reaction. the magnitude of dfp-evoked inhibition of the histamine release was not the same in each skin sample and no correlationship was observed between the magnitude of the dfp-evoked inhibition of the histamine release and that of the histamine release in the absence of dfp. the magnitude of the histamine ...	1979	84487
immunogenetics of the mcb1 macroglobulin allotype in cattle.	the paper describes a cattle serum antigen (mcb1) which is controlled by a dominant gene (mcb1), independent from those controlling the two macroglobulin markers mca1 and mca2 as well as from that controlling the low-density lipoprotein marker ld1a1. mcb1 is located on a high-molecular-weight serum protein which, very likely, is an alpha2-macroglobulin.	1979	86518
prolonged survival of corneal allografts in rabbits treated with cyclosporin a.		1979	90771
preparation of antigens for microimmunofluorescence testing for antichlamydial antibodies.		1979	90960
procaine-induced seizures in epileptic monkeys with bilateral hippocampal foci.	intravenous procaine hcl given at low doses (0.5-2.5 mg/kg) to two monkeys with bilateral alumina hippocampal foci depressed interictal spiking or had little effect. at 5.0 mg/kg unilateral limbic activation occurred. at 10.0 mg/kg unilateral or bilateral limbic activation and generalized seizures could be evoked within 3-10 min. at higher doses (15 and 20 mg/kg) bilateral limbic activation or brief (one min) generalized seizures occurred. the unilateral-onset psychomotor seizures were not ident ...	1979	91502
immunofluorescence testing for chlamydial antibodies.		1979	91742
the intra-nucleolar localization of amplified rdna in xenopus laevis oocytes.	a fluorescent feulgen-stain was adapted in order to demonstrate dna-containing structures inside the amplified nucleoli of xenopus laevis. at all stages of oogenesis this method reveals granules or complex structures of dna in each nucleolus. the micronucleoli which do not stain with this method and which do not reveal an internal structure in low molarity saline, unlike real nucleoli are considered as nucleolus-like bodies. the dna-containing structures in the nucleoli can be composed of one or ...	1979	90588
[phospholipids and blood coagulation].	after a simplified survey of the chemistry of phospholipids (pl) their presence in the lipid part of thromboplastin is dealt with, the significance of this structure being stressed. in addition, the condition, mode of action and synthesis of pl in blood platelets are extensively discussed and the impact of the composition of thrombocytic pl in the membrane and granular fraction by plasma lipid substances is referred to. the relations between single forms of pl and those proteins activating coagu ...	1979	89981
the immune response of lewis rats to peptide 68-88 of guinea pig myelin basic protein. i. t cell determinants.	a series of peptides, produced from peptide 68-88 by selective enzyme cleavage, were used to define the amino acid sequences required for the induction of experimental allergic encephalomyelitis (eae), an in vitro lymphocyte proliferative response (lpr), and serum antibody by peptide 68-88 in the lewis rat. here we present data that indicate that the t cell determinants for induction of eae, an lpr, and helper function in the production of antibody are located in the same region of the molecule ...	1979	90087
involvement of host fc receptors in antibody-mediated cutaneous basophil hypersensitivity reactions.	cutaneous basophil hypersensitivity (cbh) reactions are heterogeneous delayed time course basophil-rich responses that can be mediated by either t cells, b cells, or serum antibodies. the current study examined the mechanism by which antibodies mediate cbh in guinea pigs. fc competition experiments were constructed by passively transferring mixtures of anti-klh serum and normal heterologous gamma-globulins. it was found that rabbit igg and its isolated and purified fc fragment [but not the (fab' ...	1979	90094
degranulation of human basophils: quantitative analysis of histamine release and desensitization, due to a bivalent penicilloyl hapten.		1979	90102
[value of the method of quantitative bacterial counts for etiological diagnosis of pneumonia].		1979	90194
mechanisms of mouse mast cell activation and inactivation for ige-mediated histamine release.	the ige-mediated histamine release from mouse mast cells requires ca++, is optimal at 37 degrees c, and is enhanced by phosphatidylserine. the rate of release is relatively slow. the mast cells can be activated to release histamine by either anti-ige or anti-fab antibodies and, in the case of cells from sensitized mice, by the immunizing antigen. the incubation of mast cells with antigen in the absence of ca++ or phosphatidylserine fails to release histamine. such cells are desensitized to the f ...	1979	87441
a new method for the size estimation of the rna genome segments of influenza virus.	previous estimates of the size of the rna genome segments of influenza virus have been unreliable because of a lack of suitable rna species as size markers. we have attempted to overcome this problem by utilising the ability of amv reverse transcriptase to synthesise full length dna copies of rna molecules in the presence of a suitable primer. by comparing such dna copies of the rna segments of the influenza virus genome with sequenced restriction fragments from the e. coli plasmid pbr322, we ha ...	1979	88039
cell-mediated lysis of lipid vesicles containing eye muscle protein: implications regarding pathogenesis of graves ophthalmopathy.	we prepared artificial vesicles that are lysed upon cell-mediated immunological attack by human lymphocytes. these vesicles are made from a mixture of dimyristoyl lecithin, dipalmitoyl lecithin, and cholesterol, have eye muscle membrane protein (emp) inserted into the bilayer wall, and contain intravesicular (99m)tc marker. injury to the vesicular membrane was assessed by measurement of (99m)tc release. thyroglobulin (tg) and tg-anti-tg complex (tga) bind to emp-vesicles to an extent equal to or ...	1979	88053
automatic recognition of inter-ictal epileptic activity in prolonged eeg recordings.	a method of automatic recognition and quantification of inter-ictal epileptic activity in the human eeg had previously been developed and tested using short recordings from awake subjects. this paper describes the adaptation of the method for use during overnight recordings in free-moving unattended patients, in combination with the already existing seizure monitoring system. eeg s were recorded from scalp and sphenoidal electrodes, using cable telemetry and a pdp-12 computer. the spike and shar ...	1979	88339
hippocampal evoked potentials and eeg changes during classical conditioning in the rat.	hippocampal evoked potentials (eps) and eeg responses were studied in rats, using a classical conditioning paradigm (water, us), with a spatially discontiguous cs-us arrangement in order to separate the cs and goal-related responses. in early training, when the orienting score was high, the tone cs, instead of eliciting a definite ep, usually reset hippocampal theta activity in phase, i.e. theta rhythm became time-locked to cs. with further training, orienting activity (ori) decreased to the pre ...	1979	88362
passive sensitization of human basophils: evidence for heterogeneity in the ige molecule.	possible functional heterogeneity of human ige antibody was studied by passively sensitizing human basophils for antigen-induced histamine release. six sera of known ige anti-ragweed antigen e and total ige content were diluted to contain 10 ng of antibody but differed with respect to the ratio of specific/total ige. the relative ability of the sera to passively sensitize generally reflected the specific/total ige ratio but one serum was 2.5 times more active than the remainder. this ability did ...	1979	88417
inhibition of murine sarcoma virus-induced foci formation by cytidine analogues and other drugs chemotherapeutically effective in human malignancies.	the present report describes an in vitro culture system using the kirsten murine sarcoma virus transformation focus assay to evaluate the antiviral activities of 12 commonly used chemotherapeutically effective drugs. since these drugs are cytotoxic, the plating efficiencies of the cells treated were monitored simultaneously. using this procedure, adriamycin, daunorubicin, bleomycin camptothecin, mithramycin, hydroxyurea, 5-fluorouracil, thioguanine, 9-beta-d-arabinofuranosyladenine, 1-beta-d-ara ...	1979	88425
analysis of macrophage surface receptors. i. binding of alpha-macroglobulin . protease complexes to rabbit alveolar macrophages.		1979	88449
transient in vivo protein adsorption onto polymeric biomaterials.	the adsorption of albumin, gamma-globulin, and fibrinogen was measured on three ex vivo polymeric shunt surfaces [polyvinyl chloride (pvc), silastic, and segmented polyether urethane (biomer)] exposed to flowing heparinized, canine blood in vivo. small amounts of radiolabeled proteins were infused into anesthetized mongrel dogs and the deposition of radioactivity on the walls of femoral arteriovenous shunts was followed with time for two hours following initial blood-polymer contact. previously, ...	1979	88452
is trachoma an ocular component of a more generalised chlamydial infection?	in industrialised countries, inclusion conjunctivitis of the newborn is now known to be just one manifestation of a more generalised infection with chlamydia trachomatis. pneumonia and enteric infection can develop in perinatally infected infants. it is possible that trachoma in developing countries may reflect extraocular infection that may contribute to the high frequency of pneumonia and diarrhoea in infants in these countries. if true, this would explain the short-term effects of topical tre ...	1979	85939
identification of gallbladder typhoid carriers by a string device.	the efficiency of a gelatin capsule containing a nylon string for collection of duodenal specimens was investigated in carriers of salmonella typhosa (typhi). cultures of duodenal specimens obtained by means of the string capsule were compared with cultures of duodenal specimens obtained by a conventional duodenal tube and with stool cultures duodenal contents obtained with either the string or tube were more often positive for s. typhosa than were stool cultures. the string, which is as efficie ...	1979	86040
the isolated human cortex. a golgi analysis of krabbe's disease.	the clinical course of a child with krabbe's leukodystrophy was characterized by clinical seizures, startle myoclonus, and paroxysmal activity recorded by eeg. at autopsy in the fourth year, myelinated subcortical axons were destroyed, virtually completely. despite isolation from major subcortical and interhemispheric connections, the cell and fiber pattern of the cortex appeared remarkably normal in routine histologic preparations. the normal range of pyramidal and stellate interneurons were al ...	1979	86346
subarachnoid space of the cns, nasal mucosa, and lymphatic system.	we have briefly reviewed the literature pertaining to the movement of tracer molecules and infectious organisms within the olfactory nerve. there is a body of evidence indicating that tracers placed in the csf will quickly move via the olfactory nerve to the nasal mucosa and then to the cervical lymph nodes. organic and inorganic tracer materials and organisms as diverse as viruses, a bacillus, and an amoeba, when placed in the nasal cavity, have been shown to move from the nasal mucosa via the ...	1979	85446
evidence for two forms of rna-dependent dna polymerase in visna virus.	the visna viral rna-dependent dna polymerase has been resolved into two forms by affinity chromatography. glycerine gradient centrifugation of the two forms showed that one form sedimented at 6.9 s corresponding to an apparent molecular weight of 135 000 and the other at 6.3 s corresponding to 118 000. sodium dodecyl sulfate (sds)-polyacrylamide gel electrophoresis of the two forms indicated that the 6.9 s enzyme is composed of 2 molecules of 68 000 mol. wt. chain and the 6.3 s is a single chain ...	1979	85464
isolation of a nucleocapsid polypeptide of herpes simplex virus types 1 and 2 possessing immunologically type-specific and cross-reactive determinants.	a polypeptide (p40) of approximately 40,000 molecular weight was isolated from herpes simplex virus type 1 and 2 nucleocapsids by gel filtration and ion exchange chromatography. this protein appears to be the same as protein 22a described previously (gibson and roizman, j. virol. 10:1044--1052, 1972). competition immunoassays were developed by using purified p40 and antisera prepared in guinea pigs. the assays indicated that the p40's from herpes simplex virus types 1 and 2 possess both type-spe ...	1979	85720
factors affecting the incidence and anti-salmonella activity of the anaerobic caecal flora of the young chick.	thirty-two different types of anaerobic bacteria isolated from chickens have been tested for anti-salmonella activity in vitro. under the conditions of the test only bacteroides hypermegas and a bifidobacterium sp. were shown to inhibit the salmonellas and this was attributed to the production of volatile fatty acids (vfa's) coupled with a low ph. when these organisms were tested in newly hatched chicks no inhibition of s. typhimurium occurred. possible explanations for this observation are cons ...	1979	34658
staining of legionella pneumophila.		1979	85128
antibodies against chlamydia of lymphogranuloma-venereum type in crohn's disease.	antibodies against chlamydia of lymphogranuloma-venereum type were detected by the micro-immunofluorescence technique in 38 (69%) of 55 patients with crohn's disease. weak positive reactions were seen in only 2 or 21 patients with other gastrointestinal disorders and 1 of 50 healthy blood-donors.	1979	83465
isolation of a type-specific antigen from chlamydia trachomatis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	this report describes the isolation of a type-specific antigen of a serotype a strain of chlamydia trachomatis. the antigen could be identified in sodium dodecyl sulfate-polyacrylamide electrophoretic (sds-page) analysis of immunoprecipitates of homologously reacted lysates from bolton-hunter 125i-labeled elementary bodies, solubilized by sonication and treatment with nonidet p40. the electrophoretic pattern of this precipitate revealed a peak of unique mobility that was not reproduced by hetero ...	1979	84016
growth-stimulating factor in regenerating canine liver.	extracts from dog livers which had been regenerating for 24, 48, and 72 h after hepatectomy were infused for 6 h into the left portal vein of animals which had fresh portacaval shunts (eck fistula) and which were killed 2 and 3 days later. the brief exposure to the 48-h and especially the 72-h regenerating liver extracts induced a delayed proliferative response predominantly in the left liver lobes, with a slight spillover effect to the right liver lobes but none to the kidney. the response reac ...	1979	84151
normal immunosuppressive protein inhibition of human and murine lymphoblastoid cell line proliferation.	normal immunosuppressive protein, prepared from human plasma by deae-cellulose chromatography, inhibits dna synthesis in human cell lines of lymphocytes of both t and b origin. it also inhibits [3h]thymidine incorporation in mouse cell lines. normal immunosuppressive protein was able to inhibit the proliferation of these cells, although they were already transformed and had a high rate of dna synthesis. on the other hand, it does not inhibit myeloid cells or fibroblasts.	1979	86450
moloney lymphoma cells express a polyprotein containing the gag gene-coded p15 and the moloney leukemia virus-induced cell surface antigen (mcsa).	the relationship between mcsa and the viral structural proteins in yac moloney lymphoma cells was further investigated by using membrane immunofluorescence and immunoadsorbent columns. as previously observed, mcsa showed only minimal capping and thereby differed in behaviour from gp70, p30 and p12 virion antigens. whereas antibody-induced capping of gp70 did not change the membrane distribution of mcsa, co-capping was observed between mcsa and p30 and p12 gag protein antigens. this indicated tha ...	1979	86525
prostacyclin: a solution to some problems of extracorporeal circulation. experiments in greyhounds.	in cardiopulmonary-bypass experiments in greyhounds the effects of adding prostacyclin, prostacyclin plus heparin, and heparin alone to the extracorporeal circulation were compared. with heparin alone platelet count and function were reduced, the pressure differential across the arterial filters rose, platelet deposits were found on the arterial filters, and plasma-fibrinogen levels fell. plasma from these dogs was toxic to fetal-mouse hearts in culture. with prostacyclin alone, fibrinogen level ...	1979	86720
inclusion bodies in paneth cells.		1979	86743
low frequency of chlamydial antibodies in patients with crohn's disease and ulcerative colitis.	serum samples from 55 patients with crohn's disease and from 23 patients with ulcerative colitis were tested for antibodies to chlamydia trachomatis immunotypes by a micro-immunofluorescence technique. antibody titres of 1:8 or greater against several immunotypes were detected in 14.5% of patients with crohn's disease and in 21.7% of those with ulcerative colitis. these figures resemble the incidence in a healthy, non-venereal-disease population. furthermore, there was no correlation between the ...	1979	86884
antigenic variation in three distinct determinants of an influenza type a haemagglutinin molecule.		1979	86955
receptor cross-linking and histamine release. ii. interpretation and analysis of anomalous dose response patterns.		1979	87458
thymic control of secretory antibody responses in the rat.	the effect of neonatal thymectomy on salivary and serum antibody responses was studied in rats. local immunization of thymectomized rats with a t-dependent antigen (dnpbgg) elicited negligible amounts of iga anti-dnp antibody in saliva. in contrast, both normal and sham-thymectomized animals demonstrated substantial levels of salivary iga antibody. all thymectomized rats locally injected with a t-independent antigen (dnp-lys-ficoll) exhibited salivary iga antibody production. salivary igg antibo ...	1979	87472
the fine specificity of regulatory t cells. i. hen egg-white lysozyme-induced suppressor t cells in a genetically nonresponder mouse strain do not recognize a closely related immunogenic lysozyme.		1979	87419
lipid-modified antigens. i. specificity of guinea pig t lymphocyte responses and i-region restriction.		1979	87434
evidence for antigenic variation in influenza a nucleoprotein.		1979	88124
anaphylatoxin-induced shock and two patterns of anaphylactic shock: hemodynamics and mediators.	in the dog, different cardiorespiratory reactions were identified in two types of anaphylactic shock and in c5a-at (anaphylatoxin)-induced shock. all three types had in common a portal blood pooling with consequent decrease in the venous return, cardiac output, and arterial pressure. in anaphylaxis (a) of the first type, at a low titer of hemagglutinating antibodies, the latent period was 68 s and heart and lung function was unchanged. in the second type, at high titer, the latency was 19 s and ...	1979	88165
ethical considerations in cancer chemotherapy.	cancer treatment has improved dramatically in the recent past. as a consequence, the range of choices has been greatly broadened. with a much larger range of choices and a larger range of treatment disciplines available, decisions regarding treatment create major ethical burdens for the physician and for the patient. the participation of the patient in such choices improves the ethical posture of the therapist, whenever that is possible, and also improves the probability that the best treatment ...	1979	88204
antibody to early antigens of varicella-zoster virus during varicella and zoster.	igg antibody to the early antigens of varicella-zoster virus (vzv) was studied during both varicella and zoster by the indirect immunoperoxidase antibody technique. in parallel, complement-fixing, immune-adherence hemagglutinating, igg, and igm antibodies to vzv were studied. in both varicella and zoster infections, antibody to the early antigens of vzv appeared three to five days after onset of infection, reached a peak during the second week, and progressively decreased in titer until it disap ...	1979	88490
isoelectric focusing of chlamydia trachomatis.	hela-229 cells and the elementary bodies of chlamydia trachomatis had a net negative electrical surface charge at neutral ph when measured by isoelectric focusing. inclusion-forming and non-inclusion-forming elementary bodies focused in one band at pi 4.64.	1979	44706
abstracts of an international symposium on viral hepatitis, 5-7 april 1979, munich.		1979	41810
the stimulatory effect of 5ht and the role of the paraventricular nucleus on pms induced ovulation in the immature rat.	immature rats can be induced to ovulate with pregnant mare serum (pms) as long as they weigh over 60 g. in the rats weighing less than 60 g 5-hydroxytryptamine (5ht)-60 micrograms/rat intraventricularly or 2 micrograms/rat in the paraventricular nucleus (pvn)-stimulated ovulation. injections into several other hypothalamic nuclei were ineffective. in rats weighing greater than 60 g, lesions of the pvn or injection of 10 micrograms/rat p-chlorophenylalanine into the pvn inhibited ovulation. the h ...	1979	37456
kinetic studies in isolated organs: tools to design analgesic peptides and to analyze their receptor effects.	the opioid activities of peptide and non-peptide narcotics were studied in longitudinal muscle strip of guinea pig ileum (gpi) and in mouse vas deferens (mvd). the comparison of agonist activities of peptides found in gpi and mvd offered the opportunity to predict the presence but not the magnitude of potential analgesic activity. the kinetics of the antagonism between naltrexone and different types of agonists were also determined in these systems. using c-6 epimers of naltrexone, it was found ...	1979	33396
chronic cryptic q-fever infection of the heart.	evidence of chronic coxiella burneti infection of the heart, a disease previously considered peculiar to patients with valvular heart-disease, was found in a patient during routine serological tests before resection of a ventricular aneurysm and also by isolation of the rickettsia from the resected tissue. the patient had no symptoms or signs of q-fever endocarditis and none of the laboratory evidence usually associated with it.	1979	88607
[partial monosomy 21 in familial cystic fibrosis and ectodermal dysmorphias].		1979	88707
the influence of cyclic nucleotides on histamine release from rat peritoneal mast cells [proceedings].		1979	88893
a simple and sensitive method for the quantitative estimation of collagen.		1979	88913
systemic hyalinosis (juvenile hyaline fibromatosis). ultrastructure of the hyaline with particular reference to the cross-banded structure.	systematic hyalinosis (juvenile hyaline fibromatosis) is characterized by hyalinized skin lesions. electron microscopic examination of a hyalinized skin tumor from a 19-year-old man with this syndrome revealed that the hyaline was composed of ruthenium red-positive ultrastructures (granules, filaments, and a kind of cross-banded structure), indicating the presence of glycosamino-glycan or glycoprotein, and a small number of thin collagen fibrils. using a new ruthenium red staining method combine ...	1979	88923
preparative isolation of the cell receptor for immunoglobulin e.		1979	89114
simplified rubella haemagglutination inhibition test not requiring removal of non-specific inhibitors.		1979	89304
prospective study of chlamydial infection in neonates.	chlamydia trachomatis was recovered from the cervices of 4% (36/900) of pregnant women tested. 20 infants born through chlamydia-infected cervices were followed up for a year, as were 18 infants born to chlamydia-negative mothers. a statistically significant excess of conjunctivitis and pneumonia was found in infants exposed to chlamydia. the attack-rate for inclusion conjunctivitis was 35% (7/20) and for chlamydial pneumonia it was 20% (4/20). chlamydiae were recovered from 10 of the 20 (50%) e ...	1979	89446
failure to isolate a transmissible agent from the bone-marrow of patients with multiple sclerosis.		1979	89469
carcinomas of the liver in rats ingesting kepone.	young male and female albino rats ingested 0, 1, 5, 10 or 25 ppm kepone, an organochlorine pesticide, in the diet for two years. carcinomas of the liver, as well as hyperplastic nodules and moderate and severe diffuse hyperplasia were observed in kepone-treated rats. such hepatic lesions were not seen in control rats. female rats ingesting kepone were more susceptible than male rats to hepatic carcinogenesis. rats ingesting 50 or 80 ppm kepone developed severe diffuse hepatic hyperplasia and did ...	1979	89631
comparison of effects of pentobarbital and ethanol on the neuronal activity in the posterior parietal association cortex.	the problem of this study was whether the effects produced by alcohol in the posterior parietal association cortex are specific to this drug or shared by other centrally acting depressant drugs such as barbiturates. the effect of graded doses of pentobarbital on multineuronal impulse activity was recorded with transdural microelectrode technique in 30 expts. in brodmann's area 7 of five stump-tailed monkeys (macaca speciosa). the results were compared with those from 32 expts. performed with alc ...	1979	120109
comparison of tolerance development and dependence capacities of morphine, beta-endorphin, and [d-met2, pro5]-enkephalinamide.	the tolerance-development capacities of beta-endorphin, [d-met2, pro5]-enkephalinamide, and morphine were compared in rats, and the dependence capacity of morphine was compared with that of the enkephalin analogue in mice. tolerance to the analgesic effect, as measured by the tail-flick test, developed somewhat more rapidly in the [d-met2, pro5]-enkephalinamide-treated group than in the others. a similar relationship was found for the dependence capacity. considering that the enkephalin analogue ...	1979	108745
cardiac imaging with tantalum-178.	tantalum-178 is a potential tracer for the first transit studies of the heart. it has a short physical half-life (9.3 minutes) and is obtained as a generator product from its long-lived (21.3 days) parent, tungsten-178. first transit studies were performed in the monkey and dog following the intravenous injection of 20 mci (740 mbq) of tantalum-178. imaging was performed with a large field of view single crystal camera and a multicrystal camera. pulmonary dilution curves were derived for the ana ...	1979	108764
enhanced responsiveness to intraventricular infusion of amphetamine following its repeated systemic administration.	previous studies have demonstrated that long-term administration of d-amphetamine produces a progressive augmentation of behavior. in the present experiment, rats receiving repeated systemic injections responded to an intraventricular infusion of d-amphetamine with an augmented increase in locomotor activity. these results indicate that central mechanisms, rather than peripheral dispositional factors, subserve the enhanced behavioral response to repeated amphetamine administration.	1979	108743
effect of cyproterone acetate (ca) on growth and endocrine function in precocious puberty.	16 girls with precocious puberty have been studied. following low dosage cyproterone acetate (ca) therapy (mean daily dosage 65 mg/m2bsa) a beneficial effect on growth and skeletal maturation was observed. during high dosage therapy (150 mg/m2 per day) endocrinological studies were performed in 10 of these patients. there was no significant difference in hgh levels (insulin- and arginine-test), t3 and tsh values (trh-test) between patients and controls, t4 concentration was significantly increas ...	1979	120672
the cornea in normal condition and in groenouw's macular dystrophy.		1979	161528
effect of oral contraceptive containing a new progestin (org 2969) on plasma renin activity, growth hormone and immunoreactive insulin.	plasma renin activity (pra), growth hormone (gh) and immunoreactive insulin (iri) were studied in seven healthy subjects during the ovulatory menstrual cycle and during the first and third cycles of oral contraception with 0.05 mg of ethinylestradiol and 0.100 mg or 0.125 mg of a new progestogen, 17 alpha-ethinyl-18-methylene-4-estren-17 beta-ol. the pra level in the second half of the control cycle was significantly higher than in the beginning of the cycle. at the end of the treated cycles it ...	1979	161858