Publications

regulation of vibrio vulnificus virulence by the luxs quorum-sensing system.	vibrio vulnificus is a halophilic estuarine bacterium that causes fatal septicaemia and necrotizing wound infections. we tested whether v. vulnificus produces signalling molecules (autoinducer 1 and/or 2) stimulating vibrio harveyi quorum-sensing system 1 and/or 2. although there was no evidence for signalling system 1, we found that v. vulnificus produced a signalling activity in the culture supernatant that induced luminescence expression in v. harveyi through signalling system 2. maximal auto ...	2003	12791145
characterization of the vibrio vulnificus putap operon, encoding proline dehydrogenase and proline permease, and its differential expression in response to osmotic stress.	the vibrio vulnificus putap genes encoding a proline dehydrogenase and a proline permease are transcribed in the same direction. proline dehydrogenase activity and the level of puta transcript were determined to reach a maximum in exponential phase and were then repressed when growth slowed down. northern blotting and primer extension analyses revealed that transcription of putap genes results in two different transcripts, transcript a (puta transcript) and transcript ap (putap transcript). expr ...	2003	12813078
inflammatory cytokine response to vibrio vulnificus elicited by peripheral blood mononuclear cells from chronic alcohol users is associated with biomarkers of cellular oxidative stress.	vibrio vulnificus is the leading cause of death in the united states associated with the consumption of raw seafood, particularly oysters. in epidemiological studies, primary septicemia and inflammation-mediated septic shock caused by v. vulnificus is strongly associated with liver disease, often in the context of chronic alcohol abuse. the present study was undertaken to determine whether clinical biomarkers of liver function or cellular oxidative stress are associated with peripheral blood mon ...	2003	12819121
analysis of vibrio vulnificus from market oysters and septicemia cases for virulence markers.	representative encapsulated strains of vibrio vulnificus from market oysters and oyster-associated primary septicemia cases (25 isolates each) were tested in a blinded fashion for potential virulence markers that may distinguish strains from these two sources. these isolates were analyzed for plasmid content, for the presence of a 460-bp amplicon by randomly amplified polymorphic dna pcr, and for virulence in subcutaneously (s.c.) inoculated, iron-dextran-treated mice. similar percentages of mar ...	2003	12839775
a fatal case of vibrio vulnificus meningoencephalitis.	the objective of this paper is to report a rare case of vibrio vulnificus presenting as meningoencephalitis without a wound infection. vibrio vulnificus is capable of causing severe and often fatal infections in susceptible individuals. it commonly causes necrotizing wound infections, primary septicemia, and gastroenteritis. a 69-year-old man had meningoencephalitis with lesion on the red nucleus, substantia nigra, basal ganglia, and dentate nucleus as the initial clinical manifestation of a v. ...	2003	12848737
signal-mediated cross-talk regulates stress adaptation in vibrio species.	quorum sensing systems serve as a means of 'census taking' of conspecific and non-conspecific bacteria in the near vicinity. the acylated homoserine lactone (ahl) quorum sensing system has been proposed to be primarily an intra-specific communication system, while the ai-2 autoinducer signalling system is proposed to be an interspecific communication system. here it is shown that ai-2-like signalling in two marine vibrio species, vibrio vulnificus and 'vibrio angustum' s14, induces the core resp ...	2003	12855743
cholera and other types of vibriosis: a story of human pandemics and oysters on the half shell.	vibrios are ubiquitous in the aquatic environment and are commonly present in or on shellfish and other seafood. a small subset of strains/species are able to cause human disease, including the cholera toxin-producing strains of vibrio cholerae that are responsible for epidemic/pandemic cholera; thermostable direct hemolysin-producing strains of vibrio parahaemolyticus; and vibrio vulnificus, which can cause fulminant sepsis. cholera outbreaks can be initiated by transmission of "epidemic" v. ch ...	2003	12856219
[vibrio vulnificus septicemia transmitted through a wound caused by a crustacea].	vibrio vulnificus proliferates during the summer in salt water where it infects the crustaceans. expression of its pathogenicity depends on the underlying condition and mode of contamination.	2003	12876519
dna binding and cleavage by the periplasmic nuclease vvn: a novel structure with a known active site.	the vibrio vulnificus nuclease, vvn, is a non-specific periplasmic nuclease capable of digesting dna and rna. the crystal structure of vvn and that of vvn mutant h80a in complex with dna were resolved at 2.3 a resolution. vvn has a novel mixed alpha/beta topology containing four disulfide bridges, suggesting that vvn is not active under reducing conditions in the cytoplasm. the overall structure of vvn shows no similarity to other endonucleases; however, a known 'betabetaalpha-metal' motif is id ...	2003	12881435
antibiotic activity of lectins from marine algae against marine vibrios.	saline and aqueous ethanol extracts of marine algae and the lectins from two red algal species were assayed for their antibiotic activity against marine vibrios. experimental studies were also carried out on the influence of environmental factors on such activity, using batch cultures. the results indicated that many of the saline extracts of the algal species were active and that the activity was selective against those vibrios assayed. the algal extracts were active against vibrio pelagius and ...	2003	12884128
on-line high-performance liquid chromatography-mass spectrometric detection and quantification of n-acylhomoserine lactones, quorum sensing signal molecules, in the presence of biological matrices.	a protocol using reversed-phase liquid chromatography coupled with positive-ion electrospray ionization and ion trap mass spectrometry is described for the identification and quantification of n-acylhomoserine lactones (hsls) in crude cell-free supernatants of bacterial cultures. the hsls are produced by gram-negative bacteria and act as intercellular signals inducing density-dependent gene expression. compared with the multi-step procedures previously reported, which included chemical extractio ...	2003	12885081
vibrio vulnificus necrotizing fasciitis of the calf presenting with compartment syndrome.	we describe a 17-year-old boy with congenital spherocytosis and iron overload who presented with compartment syndrome of the calf as the initial manifestation of vibrio vulnificus infection after minor trauma in a contaminated fish pond. the disease was complicated by necrotizing fasciitis requiring above the knee amputation. childhood diseases associated with iron overload pose an increased risk for complicated v. vulnificus infections.	2003	12886899
vibrio vulnificus infection: clinical manifestations, pathogenesis, and antimicrobial therapy.	there has been a dramatic increase in the number of reported cases of infection due to vibrio vulnificus in taiwan. although the organism has been etiologically implicated in a variety of clinical syndromes, most cases of v. vulnificus infection are categorized as primary bacteremia, skin and soft tissue infection. the mortality was up to 50% in septic patients, most of them dying within 48 h of admission. in most of the cases involving v. vulnificus infection have underlying disease, particular ...	2003	12886957
vibrio vulnificus infection in a hemodialysis patient receiving intravenous iron therapy.	a 73-year-old man treated with long-term hemodialysis, erythropoietin, and intravenous iron sucrose infusions developed vibrio vulnificus infection after eating raw oysters harvested from the alabama coast. five of the 31 persons with cases of v. vulnificus infection reported to the alabama department of public health (montgomery) during 1996-2002 (including the patient described here) also had renal disease. persons with renal disease, especially those treated with long-term hemodialysis and in ...	2003	12942420
smcr and cyclic amp receptor protein coactivate vibrio vulnificus vvpe encoding elastase through the rpos-dependent promoter in a synergistic manner.	the putative virulence factors of vibrio vulnificus include an elastase, the gene product of vvpe. we previously demonstrated that vvpe expression is differentially directed by two different promoters in a growth phase-dependent manner. the activity of the stationaryphase promoter (promoter s (ps)) is dependent on rpos and is also under the positive control of cyclic amp receptor protein (crp). in this study, primer extension analyses revealed that smcr, the vibrio harveyi luxr homolog, is also ...	2003	12947096
regulation of fur expression by rpos and fur in vibrio vulnificus.	in a proteomic analysis of rpos-deficient vibrio vulnificus versus the wild type, one of the down-regulated proteins in the rpos mutant strain was identified as a fur protein, a ferric uptake regulator. the expression of a fur::luxab fusion was significantly influenced by sigma factor s, the rpos gene product, and positively regulated by fur under iron-limited conditions.	2003	13129962
severe bacterial infection in transfusion-dependent patients with thalassemia major.	the incidence and clinical spectrum of severe bacterial infection were studied in 89 patients with thalassemia major that was diagnosed between january 1971 and march 2002. there were 20 patients with 24 episodes of severe bacterial infection, resulting in an incidence of 1.6 infections per 100 patient-years. the clinical spectrum included liver abscess (6 cases), septicemia (6 cases), soft-tissue infection (2 cases), osteomyelitis (2 cases), corneal ulcer (1 case), enteritis (1 case), and absce ...	2003	13130412
characterization and pathogenic significance of vibrio vulnificus antigens preferentially expressed in septicemic patients.	many important virulence genes of pathogenic bacteria are preferentially expressed in vivo. we used the recently developed in vivo-induced antigen technology (iviat) to identify vibrio vulnificus genes induced in vivo. an expression library of v. vulnificus was screened by colony blot analysis by using pooled convalescent-phase serum that had been thoroughly adsorbed with in vitro-expressed v. vulnificus whole cells and lysates. twelve clones were selected, and the sequences of the insert dnas w ...	2003	14500463
isolation of vibrio vulnificus and atypical vibrio from surface water of the baltic sea in germany.	from 1995 to 1997 several defined species like v. alginolyticus, v. anguillarum, v. cholerae (non o1 and non o139), v. mimicus, v. parahaemolyticus and v. vulnificus were isolated during a survey to determine the presence of v. vulnificus in the brackish water of the baltic sea in germany. moreover atypical vibrio isolates were detected. four isolates belonging to a group of atypical vibrio and possibly representing a new species in the genus vibrio were characterized in detail. all four strains ...	2003	14526469
rpos-dependent stress response and exoenzyme production in vibrio vulnificus.	vibrio vulnificus is an estuarine bacterium capable of causing rapidly fatal infections through both ingestion and wound infection. like other opportunistic pathogens, v. vulnificus must adapt to potentially stressful environmental changes while living freely in seawater, upon colonization of the oyster gut, and upon infection of such diverse hosts as humans and eels. in order to begin to understand the ability of v. vulnificus to respond to such stresses, we examined the role of the alternate s ...	2003	14532069
emerging pathologies in aquaculture: effects on production and food safety.	infectious diseases represent a limiting factor for the further development of italian aquaculture. the recent introduction and spreading of new pathogens, along with the global climatic change, has contributed to a considerable decrease in trout production. emerging pathologies in rainbow trout culture include viral diseases, e.g. infectious haematopoietic necrosis (ihn), bacterial diseases, such as lactococcosis and visceral flavobacteriosis, and parasitical diseases, e.g. proliferative kidney ...	2003	14535454
necrotising fasciitis and myositis that originated from gastrointestinal bacterial infection: two fatal cases.	we present two cases of aggressive myofasciitis after gastrointestinal infections. the first patient developed necrosis of the legs over 5 days and he died on the 20th day. vibrio vulnificus was cultured. the second patient developed bullae on his thigh and he died the next day. streptococcus pyogenes was cultured.	2003	14582759
a 46-year-old man with end-stage liver disease secondary to hepatitis c with diarrhea, fever, and worsening liver failure.		2003	14603109
duplex real-time sybr green pcr assays for detection of 17 species of food- or waterborne pathogens in stools.	a duplex real-time sybr green lightcycler pcr (lc-pcr) assay with dna extraction using the qiaamp dna stool mini kit was evaluated with regard to detection of 8 of 17 species of food- or waterborne pathogens in five stool specimens in 2 h or less. the protocol used the same lc-pcr with 20 pairs of specific primers. the products formed were identified based on a melting point temperature (t(m)) curve analysis. the 17 species of food- or waterborne pathogens examined were enteroinvasive escherichi ...	2003	14605150
identification of foodborne bacteria by infrared spectroscopy using cellular fatty acid methyl esters.	identification of bacterial species by profiling fatty acid methyl esters (fames) has commonly been carried out by using a 20-min capillary gas chromatographic procedure followed by library matching of fame profiles using commercial midi databases and proprietary pattern recognition software. fast gc (5 min) fame procedures and mass spectrometric methodologies that require no lipid separation have also been reported. in this study, bacterial identification based on the rapid (2 min) infrared mea ...	2003	14607413
hepcidin: the missing link between hemochromatosis and infections.		2003	14638752
[development of asphyxia in hematogenic osteomyelitis of the mandible in a newborn infant].		2003	283596
[state of the pituitary-adrenal system in burns].		2003	201039
[multifactorial diagnosis and treatment of low back pain (author's transl)].	as a rule chronic or acute low back pain has not one, but a number of pathogenetic factors. disturbances of the supporting and locomotor systems, the cerebrospinal and autonomic nervous systems, the viscera, posture and the psyche are to be recognized and delimited. the therapeutic aim is the extinction, suppression or elimination of disturbing factors in the supporting and locomotor systems, in the peripheral voluntary and autonomic nervous systems and the psyche, in order to enable the organis ...	2003	143614
statistical analysis of epidemiological data from a chromium chemical manufacturing plant.	a statistical analysis was performed on reported bronchogenic carcinoma incidence in a group of chromium chemical manufacturing workers over the period 1929 to 1977. the purpose was to determine if post-1950 process improvements corresponded to favorable trends in morbidity. because the paucity of data on the population at risk prevented meaningful calculations of smr's, a recently developed method called "probability window analysis" was used to evaluate for statistically valid changes in the " ...	2003	430272
unusual marine pathogens causing cellulitis and bacteremia in hemodialysis patients: report of two cases and review of the literature.	cellulitis in immunocompetent hosts is usually caused by skin organisms and responds to oral antibiotics. in immunocompromised hosts, such as end-stage renal disease (esrd) patients, unusual organisms with unpredictable pathogenicity can cause infections. we present two cases with isolates that are usually encountered in coastal waters. the first case describes a 71-year-old african-american esrd patient who presented with bacteremia secondary to a wound infection after exposure to flood waters ...	2003	19379389
seasonal shifts in population structure of vibrio vulnificus in an estuarine environment as revealed by partial 16s ribosomal dna sequencing.	abstract the partial sequence (600 bp) containing the most variable region of vibrio vulnificus 16s ribosomal dna (rdna) was determined for 208 randomly selected v. vulnificus strains isolated from galveston bay, tx, usa between june 2000 and june 2001. a comparative analysis of the determined partial 16s rdna sequences revealed the existence of two different partial 16s rdna sequences (type a and type b, 1.3% base substitutions) among the 208 v. vulnificus isolates. a higher proportion of 16s r ...	2003	19719603
[liver diseases, vibrios and earth warming].		2003	16285643
[vibrio vulnificus sepsis].	a 59-year-old female patient with a history of malignant lymphoma presented with symptoms of septicaemia. the skin of the extremities showed bullous, necrotizing plaques. blood culture revealed vibrio vulnificus as the causative organism. the infection was most likely acquired while swimming in the unusually warm baltic sea through inadvertent swallowing of sea water. the disease is rare in europe. it is discussed in view of its typical clinical and histological picture.	2003	16285648
normal and abnormal upper abdominal venous structures as seen by ultrasound.	recent b-scan ultrasonic techniques have made possible the routine visualization of the major upper abdominal venous structures. real-time scanning permits in vivo dynamic assessment of the upper abdominal veins. b-scan ultrasound allows optimal anatomic resolution and is superior for the establishment of intraluminal pathology and anatomic relationships with adjacent organs. the anatomic localization of the upper abdominal veins has proved of practical importance in several ways. identification ...	2003	403799
[protein concentrations in the ejaculate of patients with chronic prostatitis].	in 158 patients suffering from chronic prostatitis and 23 healthy men seminal fluid concentrations of igg, iga, c3c, coeruloplasmin, alpha-1-antitrypsin and alpha-1-glycoprotein were determined by immunodiffusion. concentration of igg is closely correlated to leucocyte counts, that of igg, c3c, and coeruloplasmin to erythrocyte counts. c3c, coeruloplasmin, alapha-1-glycoprotein and alpha-1-antitrypsin are further correlated to sperm counts. igg and c3c concentrations are related to pathogenetic ...	2003	309878
[nurse's role in the organization of diagnostic studies].		2003	254370
from the clinic: back school.		2003	155392
dangers and interactions between drugs used in conjunction with anaesthesia.		2003	262470
[importance of ultrastructural findings for the diagnosis of primary and secondary pleural neoplasms].		2003	262293
osteogenic sarcoma of the mandible. a case report.		2003	280618
[reconstruction of abdominal wall defects using corium. surgical procedure, clinical results and manometric examination of postoperative abdominal wall function].	extensive resection of the abdominal wall was performed on six patients to reconstruct defects caused by tumors or necroses. autologous dermis covered by a flap plasty produced good clinical and functional results, documented by the measurement of intraabdominal pressures in response to coughing, pressing, and lifting of the legs. the autologous dermis graft represents a valuable tool for the closure of large defects of the abdominal wall.	2003	161976
the independent living centre.		2003	161503
an interview with robert l. clyman. the role of the pedodontist.		2003	154075
a case of giant cavernous hemangioma of the liver complicated by intravascular coagulopathy.	a case of liver hemangioma complicated by intravascular coagulopathy is presented because of the rarity of the association. hemangioma of the liver was suspected by palpation of the liver tumor, scintigraphy and x-ray examination, and confirmed by selective hepatic arteriography in combination with exploratory laparotomy. intravascular coagulopathy was established by demonstrating secondary fibrinolysis and consumption of platelets and coagulation factors. unconjugated hyperbilirubinemia due to ...	2003	148835
angiographic demonstration of bleeding into a pancreatic pseudocyst with venous drainage.		2003	143416
psycho-social aspects of recovery from coronary heart disease: a review.		2003	329420
controversy of the decade. coronary artery bypass graft (cabg) surgery.		2003	308925
[effectiveness of the comprehensive treatment by rhonidase electrophoresis and tbilisi sulfide baths of elderly patients suffering from osteoarthrosis deformans].		2003	154769
alcohol units up cure rate, census.		2003	152391
[interaction of antithymocyte globulin and immunopotentiating activity of schizophyllan (author's transl)].		2003	155747
occupational allergic contact dermatitis to isophorone diamine (ipd) used as an epoxy resin hardener.	three patients employed in the manufacture of plastic tennis rackets developed allergic contact dermatitis to isophorone diamine (ipd), an epoxy resin hardener, and concomitantly to epoxy resin. patch tests were positive to ipd at 1, 2 and 5% in olive oil and to ipd at 1, 2 and 5% in ethanol. investigations were conducted in control subjects to confirm the allergic nature of reactions. a review of the literature about ipd and related compounds is presented.	2003	149629
[vectorcardiographic aspects of complete right bundle branch block following ventriculotomy (author's transl)].		2003	148862
blood chemistry and lipid profiles of elite distance runners.	in summary, we conclude that the analysis of the blood profiles of elite runners offers no explanation for their superior fitness of physical ability when compared to the good runners. selected enzymes related to cellular or tissue damage may be elevated in distance runners and could be classified as abnormal on routine clinical evaluation if unaware of their physical lifestyles. it is also important to note that certain blood profile parameters, especially the hematocrit, could be classified as ...	2003	201207
dermatological aspects of so called vinyl chloride monomer disease.	the pathological findings revealed in 30 subjects with so called vinyl chloride disease has been presented. the most often observed symptoms were: changes in histopathological picture of the skin, history of the symptoms of raynaud's phenomenon, positive results of functional proofs (pletysmography, vibration perception test, cooling test), and scleroderma like skin lesions. acroosteolysis was found only in 3 cases, thrombocytopenia only in one. the constellation of singns may be related to the ...	2003	161529
[in memoriam professor erich zdansky].		2003	154440
the bulletin turns forty.		2003	150055
the effect of hormonal therapy on a transplantable renal cortical adenocarcinoma in syngeneic mice.		2004	4692365
the prognostic features of biochemical investigations in tetanus.	factors determining prognosis in tetanus have been based mainly on clinical grounds and mortality is high especially in the developing countries. the biochemical changes occurring in tetanus before any form of therapy or sedation, were examined to determine screening parameters for earlier institution of intensive care in high risk patients. the results obtained from a prospective study of 73 patients are presented. the blood sugar and serum transaminases correlated well with the severity of the ...	2004	517569
[value of angiotensin ii test and the "roll over test" as predictable methods of acute hypertensive disease in pregnancy (pre eclampsia and eclampsia)].		2004	520860
[a rapid method for the determination of urinary pregnandiol using sephadex lh-20 chromatography].		2004	520858
[performance of tumor markers on the es-600 system (b.m.) in routine use].		2004	3320410
[proportion of genitalia deviations in the operation material in the course of forty years (author's transl)].		2004	509277
[developmental trends, prevention and expertise in occupational diseases in the gdr].		2004	516817
[separation of immunoglobulins by ultracentrifugation in density gradients: application to rubella].	ultracentrifugation in sucrose density gradients was used to isolate rubella specific igm. we have studied three individual sera and twenty one couples among which at least one of the sera was positive by indirect immunofluorescent. there was significant correlation between the two technics.	2004	400605
[choledochoplasty in the treatment of cholelithiasis].		2004	516291
homogeneous immunoglobulins in the serum of irradiated and bone marrow reconstituted mice: the role of thymus and spleen.	the influence of thymectomy and splenectomy on the frequency and class distribution of homogeneous immunoglobulins (h-ig) in serum was studied in lethally irradiated (dba/2 x c57bl/rij)f1 mice reconstituted with syngeneic bone marrow. during four follow-up periods in the first 9 months after transplantation, the sham-operated controls and splenectomized animals developed transient h-ig in an average frequency of 14.2 and 15.7% respectively. there were no marked differences in the incidence of h- ...	2004	387578
does postnasal drip cause cough?		2004	535194
a gray scale inverter for use with ct scanners and other imaging systems.		2004	515174
folic acid and reproduction.		2004	535198
malignancies on the external ear: methods of ablation and reconstruction of defects.		2004	387840
percutaneous placement of inferior vena cava filters.	pulmonary embolism is a serious and difficult problem. many approaches for the prevention of recurrent pulmonary embolism have been tried. percutaneous placement of inferior vena cava filters is an easy, safe, available and well established procedure for the prevention of pulmonary embolism. the authors review the indications for use of ivc filters, and they review the main filters available in terms of ease of use, the physical characteristics, the technique of introduction, the efficacy and mo ...	2004	1492602
[propharmacopoea technical notes : their role].		2004	539742
[ecg diagnosis in the last 10 years].		2004	529440
[effects of mass colpocytological screening on morbidity and mortality of uterine cervical carcinoma in inhabitants of parma and experiments on the diagnostic and therapeutic value of conization].		2004	1134694
[effects of mass colpocytological screening on morbidity and mortality of uterine cervical carcinoma in inhabitants of parma and experiments on the diagnostic and therapeutic value of conization].		2004	1134694
'chronotopic' organization of goldfish optic pathway [proceedings].		2004	529075
[univentricular heart and its clinical picture].		2004	523212
congressman normal mineta: keeping tabs on the clean water act. interview by donald feliciano.		2004	522208
vascular disorders in cerebral reversible ischaemic attacks: a diagnostic study with doppler flow imaging and spectral analysis.		2004	3320286
[risks of jogging].		2004	492380
sequential intellectual recovery after near-drowning.	sequential neurological and intellectual recovery after childhood near-drowning is discussed. decisions concerning the persistence and intensity of resuscitation require a knowledge of the natural history of intellectual improvement after rescue from near-drowning. a severe case of fresh-water immersion, leading to recovery, is described. evidence is presented to suggest that the time interval of one hour before the first spontaneous respiratory gasp forms the upper limit of the apnoeic time bra ...	2004	470688
[treatment of trochanteric fractures by means of intramedullary nailing from the distal metaphysis].		2004	421608
[alcohol intoxication and its differential diagnosis (author's transl)].	acute alcohol intoxication causes a lot of diagnostic problems. every doctor should be well informed about its differential diagnostic aspects. carelessness concerning diagnosis can be detrimental to the patient and the physician as well.	2004	532410
[emergency medical service in greater copenhagen].		2004	545772
acute viral respiratory infections in children.		2004	506792
[occurrence and distribution of viral hepatitis in the gdr].		2004	463071
fallacies of medially wedged heel for valgus foot.		2004	521647
[blood pressures in gestosis patients under general anaesthesia following hypotensive treatment (author's transl)].	a retrospective evaluation was made of the blood pressures of 131 patients with hypertensive late gestosis who had undergone caesarean section for maternal or foetal indications, between 1971 and 1977. rauwolfia preparations should be avoided in both long-term and acute hypotensive treatment of late gestosis patients not only for their unfavourable impact upon circulation at large, but also for their cumulative effects in terms of drastic depression of blood pressure in case of anaesthesia neces ...	2004	532434
exercise prescription--north american experience.	the principles of exercise prescription are reviewed with respect to north american experience. the required regimen must be safe, therapeutically effective, and ensure a high rate of compliance. precautions to increase the safety of exercise are discussed. cardiac emergencies are sufficiently rare events (less than 1 in 200,000 hours even in post-coronary classes) that the need for immediate medical supervision of a well-designed programme can be questioned. the prime determinant of the respons ...	2004	444812
misuse of drugs in sport.		2004	444805
surgical removal of a left atrial myxoma during pregnancy.	successful removal of a left atrial myxoma in a pregnant woman has not been previously reported. the patient postoperatively had an uncomplicated pregnancy, delivering at term a normal, healthy baby.	2004	421587
how can teachers learn to respond effectively to their students?		2004	470754
[problems of special epidemiological risk areas in public health and social workers].		2004	463074
[study of the pulmonary vessel reaction to administration of carbon dioxide and nitroglycerin in congenital heart defects complicated by high pulmonary hypertension].	the results of functional pharmacological tests with nitroglycerine and carbon dioxide gas are presented for patients with congenital heart diseases and pulmonary hypertension, as shown during right heart catheterization. it was established that nitroglycerine, taken sublingually, does not produce any direct effect on the pulmonary artery pressure, and the delayed changes in haemodynamics are a consequence of the altered regimen of pressure in the general circulation. when carbon dioxide gas was ...	2004	404459
20 years investigations on cytochrome p-450.		2004	356059
the influence of experimental gingivitis on plaque formation.	the rate of plaque growth was assessed using daily plaque index measurements over a 7-day period in eleven dental students with an initial mean gingival indes of 1.21 (+/- 0.05). the mean gingival index was then reduced to 0.27 (+/- 0.04) and the rate of plaque growth assessed in the same way. bacterial smears were taken from the teeth at intervals during both experimental periods and percentage counts of various morphological types of bacteria made. the rate of plaque growth was found to be sig ...	2004	321485
[achievements in gastric surgery in ukraine during 60 years of the soviet rule].		2004	342803
two cases of severe sepsis due to vibrio vulnificus wound infection acquired in the baltic sea.	two severe cases of vibrio vulnificus wound infection with secondary septicemia occurred during 1 week in august 2003 on the german island of usedom in the southwestern baltic sea. in both cases, pre-existing wounds were inoculated by wading in contaminated sea water. one of the patients died from septic multiorgan failure. to the best of our knowledge, this is the first fatality due to a v. vulnificus infection to have occurred in germany. microbiological analysis revealed high concentrations o ...	2004	15599654
vibrio vulnificus infection of the upper extremity.	vibrio vulnificus is a potentially limb- and life-threatening infection. this pathogen should be suspected in any patient with a rapidly progressive infection who has a history of saltwater contact. although the infection may occur in otherwise healthy individuals, v vulnificus has a proclivity for patients with underlying chronic disease, particularly hepatic dysfunction. prompt recognition and immediate treatment with antibiotics and possibly surgical débridement may prevent amputation or deat ...	2004	15603518