Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| human mutations affecting the low density lipoprotein pathway. | 1977 | 194472 | |
| [detection of cytomegalovirus in female genitals by means of a immunofluorescent method (author's transl)]. | 1977 | 196773 | |
| phosphatidate phosphohydrolase and the regulation of glycerolipid biosynthesis. | 1977 | 196962 | |
| amebiasis. an increasing problem among homosexuals in new york city. | during a five-year period at the new york hospital, entamoeba histolytica was identified in the stools of 20 men who had not traveled outside the new york area. all of the patients were found subsequently to homosexual. during this same period amebiasis was diagnosed in 30 men who had traveled; only two were homosexual. of ten patients with e histolytica infection seen during the first year of this study, none were homosexual whereas eight of 11 patients in the fifth year were homosexual, sugges ... | 1977 | 197276 |
| substrate positions and induced-fit in crystalline adenylate kinase. | 1977 | 198550 | |
| an italian case of nasopharyngeal carcinoma correlated with epstein-barr virus specific antigens. | an italian case of nasopharyngeal carcinoma was studied clinically; the immunologic study showed the correlation with the epstein-barr virus specific antigen. | 1977 | 201063 |
| effects of peptides of pituitary origin on the formation of c21 steroid by fetal calf adrenal cells in culture. | 1977 | 201254 | |
| iron and copper metabolism in cancer, as exemplified by changes in ferritin and ceruloplasmin in rats with transplantable tumors. | 1977 | 205111 | |
| [use of antibiotics and side effects of an anti-inflammatory agent, ibuprofen, in the aged]. | 1977 | 266551 | |
| increase of proliferative activity of leukaemic blast cells from human peripheral blood in liquid culture. | the proliferative behaviour of leukaemic cells from the peripheral blood of 12 patients suffering from acute leukaemia was investigated in short term liquid culture. in 3 cases of aml an increase of the blast cell number was observed exceeding the initial value whereas in 9 other cases the cell number decreased more or less rapidly. in 9 of these patients the proliferation kinetics of the cultured leukaemic blast cells were studied with 3h-thymidine labelling. in all these cases the labelling in ... | 1977 | 267311 |
| the role of the mandible in mouse palatal development revisited. | growth changes associated with formation of the secondary palate were studied in h-velaz mouse embryos by morphometric measurement of medial sagittal sections of the heads between days 13 and 15 of embryonic development. horizontalization of the palatine processes depends primarily on the length of the mandible and is effected by a shift of palatine process material into the supralingual space. the administration of 7.5 mg cortisone acetate im to the female on day 12, of 0.5 mg 6-aminonicotinami ... | 1977 | 267520 |
| structure-function relationships in lipotropins. | 1977 | 279263 | |
| glc determination of indoprofen in plasma. | implementation of human bioavailability studies with the analgesic indoprofen required a rapid, sensitive, and convenient assay in blood plasma. a procedure based on ether extraction of acidified plasma, derivatization with diazomethane, and glc analysis using a 3% ov-1 column was sufficiently sensitive for measurement of plasma indoprofen concentrations in the 0.4-16 mug/ml range. an average recovery of 99.0 +/- 7.6% (sd) was achieved when the pentanoic acid homolog was employed as an internal ... | 1977 | 299889 |
| familial trisomy 20p five cases and two carriers in three generations a review. | a clinically normal mother of three retarded children has been determined by g-banding to have a balanced translocation 46,xx,t(13;20) (q34;p11.2). the children each have an unbalanced form of the translocation with partial trisomy for 20p. extensive gene marker studies have been unable to affix any specific gene locus onto the short arm of chromosome 20. the balanced translocation was inherited from the maternal grandfather. two phenotypically abnormal deceased members of the family are believe ... | 1977 | 302689 |
| urogastrone levels in the urine of normal adult humans. | urogastrone is a potent inhibitor of gastric acid secretion isolated from human urine and it is structurally related to and shares the properties of a potent mitogen-mouse epidermal growth factor. the amounts of urogastrone in 24 h normal human urine samples were measured using a specific and sensitive radioimmunoassay. values varied from 120--1360 ng/kg/24 h but a significant difference (2p less than 0.005) was observed between urine samples from men (602 +/- 41 se, n = 39) and women (782 +/- 4 ... | 1977 | 303242 |
| spontaneous cytotoxicity of human peripheral blood mononuclear cells toward red blood cell targets. ii. time-dependent loss of suppressor cell activity. | in a previous paper we demonstrated that human peripheral blood mononuclear cells become strikingly cytotoxic toward a wide variety of red blood cell targets after 7 days of in vitro culture. the cell responsible for cytotoxicity does not rosette with srbc and demonstrates both surface adherence and phagocytic properties. in this paper we wish to show that development of spontaneous cytotoxicity is due to a time-dependent loss of suppressor cell function. fresh autologous lymphocytes, when added ... | 1977 | 303249 |
| [traveler's diarrhea]. | 1977 | 319371 | |
| reiter's syndrome following shigella flexneri 2a: a sequel to traveler's diarrhea. report of a case with hepatitis. | shigella flexneri 2a was isolated from a patient with reiter's syndrome (rs) following a family outbreak of traveler's diarrhea. among 3 members at risk, only the patient was positive for hla-b27. data from 3 similar families support the hypothesis that susceptibility to rs is genetically transmitted. it is urged that every effort be made to culture and subtype shigella and other enteric pathogens in rs following diarrhea. concurrently, the patient had hepatitis, interpreted as a parallel enteri ... | 1977 | 319805 |
| [formation of the dysentery epidemic process in three small towns]. | data are presented concerning the epidemiological analysis of sonnei dysentery outbreaks in three towns connected by common nutrition and water supply. the epidemic processes in these populated localites were strongly interrelated. possibilities of the effect of the water factor on the extent of sonnei dysentery incidence were studied as well. the results of studies led to the conclusion on the presence of numerous action forms of the water factor which should be taken into consideration in carr ... | 1977 | 320797 |
| [test of the safety, reactogeneity and immunogeneity of live flexner 2a and sonne dysentery vaccine from spontaneous mutants, prepared in dragee form, in a controlled experiment on adults]. | controlled experiment was conducted on 428 adult persons. a study was made of the reaktogenic properties and the immunological activity of live enteral dysentery vaccine flexner 2a and sonne from the spontaneous mutants developed at the n.f. gamaleya institute of epidemiology and microbiology. the vaccine is prepared in the form of sugar-coated pills covered with an acid-fast substance protecting from the gastric juice action. a single administration of the vaccine in a dose of up to 4 pills (6 ... | 1977 | 320801 |
| volume and shape of normal human spermatozoa. | an improved apparatus for measuring the electrical size of particles, developed in this laboratory and based on the principle of the coulter counter, is used to size human spermatozoa. the typical size distribution is unimodel, with a skew to the right. the actual quantity determined by the measuring system is electrical size (i.e., shape factor x volume); in order to extract the volume, it is necessary to obtain an independence measure of particle shape. this is done by estimating the relative ... | 1977 | 321264 |
| conservation of transfer ribonucleic acid and 5s ribonucleic acid cistrons in enterobacteriaceae. | the genes for tranfer ribonucleic acid (tdna) and 5s ribonucleic acid (5sdna) were isolated from the total deoxyribonucleic acid (dna) of escherichia coli. the relatedness of tdna and 5s from e. coli and other species of enterobacteriaceae was determined by reassociation of the isolated genes labeled with 32po4 to unlabeled, unfractionated dna. double-stranded dna was separated from unreacted dna by hydroxyapatite chromatography. thermal elution profiles were done to determine the amount of unpa ... | 1977 | 321428 |
| a simple one-step hemolytic assay for c2 with c2-deficient human serum. | a simple one-step procedure has been developed for the molecular titration of c2 by utilizing the ability of the test material to restore the hemolytic activity of human serum selectively deficient in c2 (c2d serum). in this assay, equal volumes of ea (10(8) cells/ml), c2d serum (1/20), and a suitable dilution of a source of c2 were incubated at 37 degrees c for 60 min and the fraction of cells lysed was used to calculate the effective molecules of c2/ml test material. the assay can be used to t ... | 1977 | 321681 |
| protection by hypoxia and the effect of low oxygen tensions on radiosensitivity. | 1977 | 323029 | |
| biological properties of shigella flexneri 2a toxin and its serological relationship to shigella dysenteriae 1 toxin. | a toxin extracted from heat-inactivated, alkaline-treated shigella flexneri 2a showed biological properties similar to those of shigella dysenteria 1 toxin. the s, flexneri 2a toxin was lethal to mice, enterotoxic for ileal loops of rabbits, and cytotoxic for hela cells. a serological relationship between s. flexneri 2a and s. dysenteriae 1 toxin was shown with cross neutralization tests. | 1977 | 323142 |
| the pathogenesis of shigella diarrhea. vi. toxin and antitoxin in shigella flexneri and shigella sonnei infections in humans. | two strains of shigella flexneri and one of shigella sonnei were studied for toxin production in vitro. all of the three strains produced a cell-free cytotoxin that showed marked similarity to that produced by shigella dysenteriae 1. each toxin eluted in two distinct peaks on chromatography with sephadex g-150, was destroyed by heating at 90 c for 30 min, and was neutralized by s. dysenteriae 1 antitoxin. patients with infections due to s. flexneri and s. sonnei developed antibody that neutraliz ... | 1977 | 323376 |
| clinical and laboratory assessment of the pathogenicity of serotyped enteropathogenic escherichia coli. | only one of 167 separate isolates of enteropathogenic escherichia coli (eec) was shown to produce enterotoxin, and none of the 167 isolates were invasive. clinical features of 123 hospitalized children with eec were compared with those of 917 infants with nonbacterial gastroenteritis and 145 infants infected with shigella. the average duration of diarrhea (five or more stools per day) in hospitalized children with eec, nonbacterial gastroenteritis, shigella flexneri, and shigella sonnei was 4.6, ... | 1977 | 323379 |
| phagocytosis stimulation by an extracellular product of virulent shigella flexneri 2a. | 1977 | 323646 | |
| trimethoprim-sulfamethoxazole compared to ampicillin in the treatment of shigellosis. | twenty hospitalized children between 1 and 11 years of age were enrolled in a comparative randomized evaluation of trimethoprim-sulfamethoxazole (tm-sm) and ampicillin for the treatment of shigellosis. each drug was provided for five days. the group treated with ampicillin had significantly more stools per day (mean 21.25) compared to the tm-sm group (8.64). treatment with tm-sm appeared to be associated with a more rapid reversion of stool cultures to normal, but these differences compared to a ... | 1977 | 323811 |
| [functioning of the kspa-gene in f'-merodiploids of flexner shigellae]. | 1977 | 324195 | |
| [diagnosis and treatment of acute dysentery]. | 1977 | 325896 | |
| [our experiences with water-induced epidemics of bacillary dysentery]. | 1977 | 325899 | |
| postdysenteric reiter's syndrome. | 1977 | 325904 | |
| [biological activity of extracts isolated from a virulent strain of sh. flexneri grown in the presence of calcium ions]. | the authors carried out a comparative study of the genetically connected sh. flexneri cultures (3 virulent strains, 3 clones of an avirulent mutant selected in the flux of an oblique light from the virulent strain, and lac+ kcp a-hybrids obtained by crossing the initial virulent cultures with the e. coli k12 hfr strains). the absence of any correlation between the virulence of the strains under study and the lipopolysaccharide (by rhamnose) content in the extracts from them in growing the cultur ... | 1977 | 325961 |
| [immunochemistry of shigellae (review of important results). 1. o-antigens of flexner shigellae (characteristics and isolation)]. | 1977 | 325963 | |
| [study of a "rfa" locus coding for cell wall lipopolysaccharide core biosynthesis in "shigella flexneri" f6s (author's transl)]. | the rfa-7 lipopolysaccharide core mutation carried by the r mutant f680, derived from shigella flexneri f6s serotype 5b, has been mapped by conjugation and transduction experiments. the results show a chromosomal distance of about 1 min between rfa-7 and mtl. such a position would be similar to those of rfa genes in escherichia coli k12 and salmonella typhi-murium lt2. conjugational transfer of e. coli k12 rfa+ genes to mutant f680 restored s. flexneri o-specificity. chemical analyses performed ... | 1977 | 326120 |
| spectrophotometry as a tool for assaying endotoxins. | a spectrophotometric method is reported for assaying endotoxins over a wide concentration range, including low parts per billion levels. five solution of endotoxins. escherichia coli 0127:b8, escherichia coli 055:b5, salmonella abortus-equi, salmonella enteritidis, and shigella flexneri, were examined. each exhibited an absorption maximum at 259 nm, but the absorptivities differed in each case. thus, rigorous quantification requires that the identity of the endotoxin be known. the uv absorbance ... | 1977 | 327056 |
| [sensitivity of shigella to antibiotics]. | 1977 | 327917 | |
| rough mutant of shigella flexneri 2a that penetrates tissue culture cells but does not evoke keratoconjunctivitis in guinea pigs. | a rough mutant, designated 5503-01, has been isolated from a virulent strain of shigella flexneri 2a 5503. strain 5503-01 produced smooth opaque colonies, whereas its parent strain produced characteristic green-gold translucent ones. characterization of 5503-01 by agglutination tests, rhamnose content, and sensitivity spectra to "rough-specific" phages revealed that it had lost the specific somatic antigens. when 5503-01 was used to infect hela or l cells, it penetrated the cells and multiplied ... | 1977 | 328396 |
| incompatibility and bacteriophage inhibition properties of n-1, a plasmid belonging to the h2 incompatibility group. | n-1, a plasmid isolated from a strain of shigella flexneri in japan more than 10 years ago, mediates the phage inhibition phenotype which has recently been found to be characteristic of plasmids of the h2 incompatibility group. using the criteria of phage inhibition, surface exclusion and incompatibility, the n-1 plasmid is shown to be closely related to h2 plasmids isolated from non-typhoid salmonella and distantly related to h1 plasmids isolated from salmonella typhi. plasmids of other incompa ... | 1977 | 329103 |
| [dysentery]. | 1977 | 329360 | |
| [electron microscopic study of the interaction of shigellae with cell cultures. iii. functional-structural changes in transplanted amniotic cells exposed to extracellular flexner shigellae]. | a quantitative changes of rna and proteins and structural peculiarities of compensative-regenerative character were discovered in amnion cells subjected to the action of extracellular virulent shigellas by means of successive cytophotometry and electron microscopy. the long contact with the bacteria lead to increased degenerative changes in the cell cytoplasm. the arising changes seem to involve toxicity caused by the action of exometabolites of shigella flexneri. | 1977 | 329505 |
| structural studies of the shigella flexneri variant x, type 5 a and type 5 b o-antigens. | previous studies of different shigella flexneri o-antigens indicate that their o-specific region is composed of oligosaccharide repeating units containing a basic tetrasaccharide structure, to which alpha-d-glucopyranosyl groups and o-acetyl groups may be attached to different positions. structural studies of o-antigens from variant x, type 5a and type 5b lend further support to this assumption. these antigens contain terminal alpha-d-glucopyranosyl groups, one each per repeating unit in x and 5 ... | 1977 | 330159 |
| antagonistic effect of extremely oxygen-sensitive clostridia from the microflora of conventional mice and of escherichia coli against shigella flexneri in the digestive tract of gnotobiotic mice. | two extremely oxygen-sensitive strains of clostridium sp., designated clostridium e and p, were obtained from digestive microflora of conventional mice and found to constitute a barrier against shigella flexneri sf-2 when associated in vivo with escherichia coli k-12. these and other simplified fractions of the conventional microflora were demonstrated to have an effect comparable to that of the total flora. when k-12 and clostridium e were established in gnotobiotic mice before the introduction ... | 1977 | 330410 |
| use of omega-aminohexyl-sepharose in the fractionation of escherichia coli b aminoacyl-trna synthetases. | the usefulness of aminohexyl-sepharose in purification of e. coli b aminoacyl-trna synthetases is presented. the purification factors for 14 synthetases lie in the range 3- to 94-fold and the recoveries of the enzymatic activity were 30-80%, depending on the enzyme. | 1977 | 330554 |
| [the survival time of shigellas on plastic materials]. | 1977 | 331701 | |
| [epidemiology of dysentery in dagestan]. | analysis of material on bacterial dysentery and other acute intestinal infections morbidity in the dagestan assr for a period of 15 years showed high morbidity level and its variations, with reduction and elevation in individual years, and the leading role played by shigella flexneri among the causative agents of dysentery. the greatest incidence of dysentery was revealed among children aged under one year and between 1 and 2 years. a high bacterial dysentery incidence was recorded in dagestan t ... | 1977 | 331761 |
| [comparative characteristics of cell-free filtrates of shigella flexneri of different virulence]. | it was shown for the first time that the virulent sh. flexneri strain grown on luria broth differed from the avirulent one by the yield of readily released surface-located complexes--lipopolysaccharide (determined by rhamnose) and protein into the filtrate. there was no distinct correlation between the strain virulence and the content of rhamnose-determined lipopolysaccharide in the filtrate; growing bacteria in the presence of ca and mg ions had no significant influence on the lipopolysaccharid ... | 1977 | 331764 |
| [intraspecies antagonism of sh. flexneri in an hep-2 cell line model]. | the authors describe an effect of suppression of invasion of the guinea pig eye conjunctiva and the hep-2 epithelial cells by virulent sh. flexneri bacilli, with a simultaneous administration of the same dose of avirulent shigella mutants, genetically connected with them. the data of morphological study and experiments with 3h-glucose labeled shigellae carried out on the cell species model indicated that the bacterial competition for the specific sites for absorption on the epithelial cells unde ... | 1977 | 331774 |
| [r-factor transmission during interspecies crossing of shigella and salmonella]. | 1977 | 331777 | |
| [physico-chemical parameters of the surface of flexner shigella cells and the structure of lipopolysaccharide o-antigen]. | 1977 | 331779 | |
| [experimental salmonellosis conjunctivitis and keratitis in guinea pigs]. | the authors present the results of morphological study of experimentally-induced conjunctivitis and keratitis induced in guinea pigs by salmonellae. it was revealed that injuries of the conjunctiva and cornea in salmonellae infection were different by development and morphological manifestations from keratoconjunctivitis caused by shigellae. this difference was due to specific peculiarities of the pathogenic properties of salmonellae and shigellae clearly expressed on the given experimental mode ... | 1977 | 331788 |
| [interspecies antagonism of dysentery bacteria]. | 1977 | 331789 | |
| [immunochemistry of shigellae. ii. o-antigen of flexner shigellae (chemical structure and relationship to serological properties)]. | 1977 | 331790 | |
| [phage conversion of escherichia and shigella antigens. i. phage conversion of type i antigen of sh. flexneri in entrophatogenic e. coli o129]. | the authors realized conversion of type i sh. flexneri in enteropathogenic e. coli o129 with converting moderate phage phi i sh. flexneri. phage phi i lysogenized 7.3--42.7% of the cells of antigenic e. coli variant o129 which lost type v antigen; conversion of the type i antigen of sh. flexneri was revealed in the agglutination and adsorption of agglutinins tests. as a result, e. coli strain was obtained with the o-antigen identical to the o-antigen of sh. flexneri ia. | 1977 | 331793 |
| basic structure of the oligosaccharide repeating-unit of the shigella flexneri o-antigens. | 1977 | 332361 | |
| quantitative in vitro phagocytic rate measurements. | a model for the calculation of phagocytic rate constants based on the assumption that the process of phagocytosis can be treated in a manner analogous to chemical reactions of the first order is suggested. by employing such an approach, accurate rate constants of ingestion of in vitro cultivated macrophages can be obtained following minimal time intervals from the onset of phagocytosis. | 1977 | 333027 |
| shigella surveillance in the united states, 1975. | 1977 | 333038 | |
| algorithms in the diagnosis and management of exotic diseases. xxvii. shigellosis. | 1977 | 333040 | |
| studies with a new generation of oral attenuated shigella vaccine: escherichia coli bearing surface antigens of shigella flexneri. | in an attempt to develop a safe, proliferating, oral, attenuated vaccine against shigellosis, genes that control the synthesis of group- and type-specific somatic antigens of shigella flexneri 2a were transferred via conjugation to a recipient strain of escherichia coli. the resultant hybrid (e. coli expressing shigella surface antigens) vaccine strain, pgai 42-1-15, believed to have a complete (smooth) lipopolysaccharide, was given to volunteers in two vaccination-challenge studies. the vaccine ... | 1977 | 333041 |
| a possible role of glycolipids in epithelial cell penetration by virulent shigella flexneri 2a. | 1977 | 333234 | |
| [clinical aspects and treatment of dysentery]. | 1977 | 333732 | |
| [immunologic properties of soluble shigella antigens]. | of the live sh. flexner 2a and sonne soluble antigens containing glucide-lipoid-protein complex, characterized by low toxicity, a high yield of dry substances, and the capacity to induce immunity production in mice after subcutaneous and oral immunization, were obtained by salt extraction and physical disintegration. local antigen application into eye mucosa of guinea pigs produced local resistance against homologous causative agents and also stimulated production of the highest level of specifi ... | 1977 | 335736 |
| venereal transmission of shigellosis in seattle-king county. | in the past, shigellosis in seattle-king county has been primarily a disease of children, their parients, and foreign travelers. during the 18 months beginning in july 1975, an outbreak of shigellosis in seattle's community of gay men involved both shigella flexneri and shigella sonnei. they accounted for nearly 30% of all cases of shigellosis reported to the health department. fellatio and/or oral-anal contact was reported by 90% of the infected homosexual men; this was probably the mechanism o ... | 1977 | 337539 |
| [structure of shigella antigens. heterogeneity of specific polysaccharides of 2 shigella flexneri strains and 2 sh. flexneri/escherichia coli hybrids]. | the s-specific polysaccharide from 2 sh. flexneri wild strains (with serological var. x- and var. y-specificity, respectively) and 2 sh. flexneri e. coli hybrids (with the same specificities) can be separated by means of gel chromatography on sephadex g-200 and g-50 into altogether 6 fractions per strain. fraction g-200/1 (molecular weight greater than 10(6)d) represents a polymer consisting nearly exclusively of glucose and is present mainly in the two y-type strains, much less in the two x-typ ... | 1977 | 337687 |
| [assessment of the diagnostic effectiveness of antigenic preparations from sonne shigellae]. | the authors studied the diagnostic possibilities of 4 diagnistic agents from sh. sonnei. a total of 1500 from 1122 persons were investigated. specificity and sensitivity of the diagnostic agents from sh. sonnei were determined. methodical priciples of the objective assessment of the diagnostic efficacy of the antigenic preparations in the controlled epidemiological trial were elaborated. a possibility of establishment of the etiological diagnosis of sonne dysentery in the passive hemagglutinati ... | 1977 | 339617 |
| [results of treatment of dysentery patients with streptomycin-dependent vaccine in comparison with other methods of treatment]. | comparative study of various methods of treatment was carried out on 777 patients suffering from acute dysentery with a bacteriologically confirmed diagnosis. to assess the therapeutic efficacy, along with consideration of clinical signs of the disease, immunoglobulin level was examined in the blood and coprofiltrates; also the state of reparative processes in the mucosa was appreciated by the histological examination of the biopsy material. results of the work carried out indicated the inexpedi ... | 1977 | 339618 |
| [study of the mechanism of reduction of the virulence in the shigella flexneri strains resistant to streptomycin]. | streptomycin-resistant mutations in donor strains of e. coli k12 hfr ab 313 and at-13 are not associated with the action of the stra-gene limiting the suppression. shigella mutations str-r obtained by the method described in this paper also failed to limit the suppression. changes in the virulence observed in transmission stra region from the str-r strains of e. coli and shigellae used in this work were not connected with mutations limiting the suppression (with competent mutations). | 1977 | 339620 |
| [clinico-immunological characteristics of dysentery in persons with different blood groups]. | the authors studied the frequency of distribution of the abo system blood groups in 392 adults and 322 children suffering from acute dysentery. x2 criterion and double-factor dispersion analysis were used for statistical analysis. deficiency of persons with b iii and ab iv blood group. phagocytosis indices were decreased in them with the elevated neutrophil damage index. | 1977 | 339628 |
| [phage conversion of the antigens in escherichiae and shigellae. 2. conversion of the somatic antigen in shigella flexneri with the moderate e. coli 0129 phage]. | the authors studied the converting activity of the moderate ef5 phage isolated from the lysogenic e. coli 0129 strain. it was shown that this phage converted the o-antigen with the detection of the type antigen v in the strains of sh. flexneri of the serological type la and y-variant. the converted cultures contained the type antigen v and were identical by the antigenic properties to one another and the sh. flexneri of the serological type 5 and e. coli 0129. a conclusion was drawn that phages ... | 1977 | 339629 |
| [histamine metabolism in acute dysentery and nonspecific ulcerative colitis]. | 1977 | 341350 | |
| on the metabolic characteristics of shigella flexneri x escherichia coli, devoid of ability for intracellular multiplication in epithelial cells. iii. oxygen uptake and dehydrogenase activity. | the oxygen uptake and dehydrogenase activity of avirulent xyl+ and xyl- str hybrids (kcp-), obtained from virulent strains sh. flexneri (sh. flexneri 222 5 a and sh. flexneri m42-432a) and donor strain e. coli ab 313, devoid of ability for intracellular multiplication in epithelial cells are studied. some tricarboxylic acid intermediates, hexoses and pentoses were used as substrates. a definite tendency has been established, indicating a decreased rate of oxygen consumption and dehydrogenase act ... | 1977 | 341601 |
| [experimental study, using a pulmonary model, of the pathogenic properties of genetically related strains of sh. flexneri, differing in their ability to cause keratoconjunctivitis]. | complex microbiological and morphological study of the genetically connected sh. flexneri strains, avirulent by keratoconjunctival test showed that the greatest extent of the virulent loss was revealed in shigellae with mutation in the area glpk-gene: they lost the capacity to penetrate into the cells of the bronchial epithelium, to resist local leukocytic reaction and to produce an injurious action on the pulmonary vessels. shigellae with the replaced kcpa- gene area mostly lost the capacity to ... | 1977 | 341614 |
| phenotypic correction of nonsense mutation carrying non-converting pe5 phages in shigella flexneri with suppressor gene. | (i) phenotypic suppression by aminoglycoside antibiotics of a polyauxotrophic shigella flexneri var. y strain on partially completed minimal medium has shown that its thr dependence is associated with nonsense mutation. induced thr+ revertants selected from the culture yielded clones correcting the lytic cycle of nonsense t4 mutant phages. transfer of r1am plasmid to these clones carrying a nonsense mutation of ampicillin resistance was performed. in this manner a s. flexneri var. y derivative w ... | 1977 | 341654 |
| phage typing and bacteriocin typing of shigella strains isolated in romania from sporadic and epidemic dysentery cases. | 1977 | 341847 | |
| the aetiology of dysentery-like diseases and the biology of their causative agents. | 1977 | 346997 | |
| the role of cellular locomotion in leukemic infiltration. an organ culture study on penetration of l 5222 rat leukemia cells into the chick embryo mesonephros. | the significance of cellular locomotion for leukemic infiltration was investigated using l 5222 rat leukemia cells. previous cinemicrographic studies have shown that these cells are able to locomote only after formation of a uropod-like posterior extension. this characteristic locomotive configuration of l 5222 cells is easily recognizable in scanning electron micrographs and appropriate sections. leukemia cells were inoculated on slices of chick embryo mesonephros incubated for 24h; at this tim ... | 1977 | 403674 |
| neurite induction in mature cortical neurones in feline gm1-ganglioside storage disease. | 1977 | 404568 | |
| effects of 19-hydroxy-prostaglandins on oviductal and uterine motility. | the effects of 19-hydroxyprostaglandins (19-oh-pgs) were tested in vivo on the rabbit oviduct and uterus and on the rhesus monkey (macaca mulatta) uterus. the 19-oh-pges suppressed spontaneous oviductal and uterine activity in the rabbit. the qualitative effect on the rabbit oviduct of 19-oh-pges was similar to that of pge2. however, the typical response of the rabbit uterus to pge2 was an increase in muscle activity. with regard to the rabbit oviduct, 19(r)-oh-pge2 was as potent as pge2, but 19 ... | 1977 | 404673 |
| [study of intestinal infections in experiments on monkeys]. | 1977 | 410189 | |
| oral immunization of monkeys with polyvalent dysentery vaccine. | macaca mulatta monkeys were immunized orally with polyvalent boivin extract of shigella flexneri 2a, 3a, 4a, 4b, 6 and shigella sonnei. the total immumizing dose for each component was equivalent to 1.2 x 10(12) cells. after challenge with 7.5 x 10(10) cells of a virulent s. flexneri 2a strain, out of 20 immunized animals 2 developed dysentery and 4 showed mild dyspepsia; all 6 control animals became ill with dysentery. vaccination failed to influence the incidence, duration or the intermittent ... | 1977 | 412396 |
| [safety and immunologic effectiveness of polyantigen from shigellae for oral immunization of monkeys]. | clinical, morphological, and immunological study was carried out in monkeys given shigellae antigen in tablets orally. each tablet contained 0.5 mg of the antigens obtained by boiven's method from sh. flexneri 2a, 3, 4a, 4b, 6 and sh. sonnei. daily administration of the preparation for 4 days and then 4 times at the interval of 5 days proved to be harmless for monkeys. a marked immunomorphological reaction in the form of hyperplasia of the lymphoid elements of the wall of the large intestine and ... | 1977 | 413291 |
| theileria parva piroplasmosis in mice, and its attempted transmission with rhipicephalus appendiculatus ticks. | theileria parva piroplasm infection of mouse erythrocytes was detected, following intraperitoneal inoculation of mice with irradiated cultures of t. parva-infected bovine lymphoid cells. infection could not be transmitted to cattle using rhipicephalus appendiculatus ticks. | 1977 | 414389 |
| the use of tetracyclines on the chemotherapy of experimental east coast fever (theileria parva infection of cattle). | in a series of experiments, groups of cattle, undergoing patent east coast fever (ecf) reactions induced by the inoculation of tick-derived stabilates of theileria parva infective particles, were treated by parenteral administration of 2 tetracyclines. ten cattle were treated with n-pyrrolidinomethyl tetracycline at 15 mg/kg for 5 days, starting on the first day macroschizonts were detected in lymph node biopsy smears. nine of these treated cattle survived ecf reactions induced by an inoculum wh ... | 1977 | 414390 |
| monocyte function in familial mediterranean fever. | monocytes derived from the peripheral blood of patients with familial mediterranean fever (fmf) demonstrated a consistently lower phagocytic capacity (38-44%) for 125i-labelled shigella flexneri when compared to monocytes from healthy subjects. phagocytosis of both viable and killed staphylococcus albus was similar in patients and controls. however, fmf monocytes had a two- to eight-fold depressed bactericidal capacity against s. albus in comparison to normal monocytes. acid phosphatase and beta ... | 1977 | 345807 |
| rifampicin therapy in shigellosis in infancy. | eleven infants aged 1-2 years suffering from shigellosis associated with shigella flexneri type 6 were treated with rifampicin. all were initially treated with antimicrobial drugs to which sh. flexneri was shown to be sensitive, but without effect. rifampicin was effective in curing gastrointestinal symptoms and eradicating the bacilli in all infants in 5 days. the drug was given in a dose of 10-12 mg/kg per day divided into two equal parts, for 7 days. no untoward side effects were observed. ou ... | 1977 | 343724 |
| proposals for quality control methods of bacterial vaccines for immunostimulation. iii. effect of bcg and c. parvum on in vivo listeria clearance and tumor growth. | two quality control methods for bcg and c. parvum are described. first, in vivo macrophage dependent-spleen clearance of listeria monocytogenes in inbred b10lp mice. bcg and c. parvum were administered intravenously prior to listeria inoculation (a prophylactic model). conditions for enhanced listeria clearance including dose, route and time interval were described for each vaccine. next, a tumor model was developed: i.e. a fibrosarcoma, chemically induced by 20-methylcholanthrene in inbred balb ... | 1977 | 415924 |
| presence of common idiotypes on antibodies induced by glutamic acid-lysine-containing terpolymers in responder and nonresponder mice with the ig-1b heavy chain allotype. | a b10.a (5r) responder mouse to the random linear terpolymer, poly--(glu, lys, phe), glphi, can produce immunoglobulins which bind poly-l (glu, lys), gl, that share idiotypic determinants with gl-binding antibodies produced by other members of the same strain. expression of these common idiotypic determinants, termed bgl, is independent of the h-2 halotype and closely linked to the ig-lb heavy chain allotype. moreover, nonresponder mice with the ig-lb heavy chain allotype, when immunized with gl ... | 1977 | 415884 |
| dog bites. | dog bites can be prevented by proper education of children, appropriate selection of family pets and the restraint of guard dogs in the community. an unusually high incidence of bites by german shepherds was observed in this study. treatment of injuries inflicted by dogs should include: careful wound toilet, appropriate excision of damaged tissues, careful wound repair with adequate drainage and systematic therapy with selected antibiotics. | 1977 | 556659 |
| in vitro activity of cinoxacin, ampicillin, and chloramphenicol against shigella and nontyphoid salmonella. | the in vitro antibacterial activity of cinoxacin was compared with that of ampicillin and chloramphenicol against 26 strains of nontyphoid salmonella and 44 strains of shigella. cinoxacin was found to have a lower minimal inhibitory concentration than ampicillin and chloramphenicol against all salmonella and shigella sonnei strains. cinoxacin had minimal inhibitory concentrations similar to those of chloramphenicol but lower than those of ampicillin against shigella flexneri and s. boydii strain ... | 1977 | 856008 |
| oesophageal reflux and its myths. | 1977 | 421073 | |
| [a new technic of substitute stomach formation; merguet's modification]. | 1977 | 352030 | |
| computer tomography, radionuclide imaging and ultrasonography in hepatic mass lesions. | the livers of 86 patients comprising this report were examined by both transmission computerized tomography (ct) and radionuclide scans (ls). fifty-nine of them were also examined by gray-scale ultrasound (us). in a comparative study, the strengths and weaknesses of each modality were evaluated. ct demonstrated 85%. us 82%, and ls 73% of masses involving the liver. because of better resolution and sectioning capabilities, together with stop-motion imaging, ct and us detected smaller and deeper m ... | 1977 | 421442 |
| [shigella flexneri diarrhoea with positive blood culture]. | 1978 | 16114334 | |
| oxolinic acid for the treatment of chronic gastrointestinal shigella carriers. | two patients were long-term gastrointestinal carriers of shigella flexneri for 23 mo and 6 mo, respectively. neither patient responded to oral antibiotics, despite in vitro sensitivity of the bacteria to the antibiotics administered. oral oxolinic acid produced immediate cessation of the carrier state in both patients, with resolution of minor but persistent physical complaints. | 1978 | 686252 |
| specific antiserum to the main intrinsic polypeptide of chick lens fiber cell plasma membranes. | 1978 | 415893 | |
| pharmacokinetics of intracarotid artery 14c-bcnu in the squirrel monkey. | a comparison of intravenous to intracarotid artery (ica) administration of 14c-bcnu (1,3-bis(2-chloroethyl)-1-nitrosourea) was made in squirrel monkeys. radioactivity was measured as soluble drug products and as rna-, dna-, and protein-bound radioactivity. the ica administration of bcnu achieved 190% to 280% higher brain nucleic acid-bound drug levels than use of the intravenous route in the infused hemisphere and 130% to 280% higher levels than in the noninfused hemisphere. in addition, some br ... | 1978 | 416182 |
| quantitative toxicology: interlaboratory and intermethod evaluation in new york state. | the new york state department of health has conducted a proficiency evaluation program in quantitative toxicology since 1974. serum samples containing a barbiturate and phenytoin, together with either glutethimide, procainamide, or theophylline, are sent to participating laboratories quarterly. within the first two years of the program the percentage of laboratories able to quantitate 75% of the test samples to within 25% of the gravimetric values increased from 25 (1974-1975) to 40% (1975-1976) ... | 1978 | 343948 |
| eosinophils chemotactic factor (ecf). iv. inhibitory activity in human peripheral leukocytes. | a low molecular weight eosinophil chemotactic factor (ecf) can be released from human peripheral polymorphonuclear leukocytes by phagocytosis, by reverse anaphylaxis or by the calcium ionophore a 23187. during later phases of ecf-release, a leukocyte-derived ecf inhibitor (ldi) is concomitantly released. inhibitory activity is also present in sonicates of unstimulated cells, suggesting that the factor is preformed. on chromatographic analysis of neutrophil (pmn) sonicates, two peaks of inhibitor ... | 1978 | 344231 |
| [clinical and rectoscopic characteristics of dysentery with accompanying helminthic invasion]. | 1978 | 344988 |