Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| treatment of helicobacter pylori-associated gastroduodenal disease in children. clinical evaluation of antisecretory vs antibacterial therapy. | the charts of 54 children diagnosed with antral h. pylori were reviewed, to establish the incidence of gastroduodenal inflammation and compare therapeutic efficacies of antisecretory vs. antibacterial therapy. histology demonstrated normal mucosa in three cases (6%) and gastric/duodenal inflammation (> or = whitehead grade 3) in 51 biopsies (94%). 23/43 children (53%) initially responded to h2-blockers; however, by 10 mo, 13 had relapsed clinically. all of these patients subsequently responded t ... | 1993 | 8093598 |
| h pylori-initiated ulcerogenesis: look to the host. | 1993 | 8093924 | |
| helicobacter pylori in dental plaque. | 1993 | 8094153 | |
| pcr identification of helicobacter pylori in faeces from gastritis patients. | 1993 | 8094221 | |
| uncomplicated peptic ulcer disease. an overview of formation and treatment principles. | the end point in peptic ulcer disease is a crater in the mucosa. the cause of gastric ulcers seems to be the breakdown of defensive factors, which then allows damage from endogenous and/or exogenous aggressive factors. aggressive factors are more important in duodenal ulcer formation. treatment options discussed herein have similar clinical effectiveness, and all have better results than placebo. selection of a specific agent should be individualized. helicobacter pylori infection has been impli ... | 1993 | 8095330 |
| refractory peptic lesions. therapeutic strategies for ulcers and reflux esophagitis that resist standard regimens. | in some patients, peptic lesions fail to heal after 2 to 3 months of standard histamine2 (h2) receptor antagonist or sucralfate (carafate) therapy. noncompliance with prescribed treatment, cigarette smoking, gastric acid hypersecretory states (including zollinger-ellison syndrome), helicobacter pylori infection, the use of nonsteroidal anti-inflammatory drugs, abdominal radiation therapy, and malignant tumors are all causes of refractory disease. treatment options include high-dose h2 receptor a ... | 1993 | 8095331 |
| the impact of therapeutic improvements in reducing peptic ulcer mortality in europe. | trends in death certification rates from peptic ulcer between 1955 and 1989 have been analysed for 24 european countries on the basis of age-specific and age-standardized rates, and a log-linear model to estimate the effects of age, cohort of birth and period of death. for males, in all western countries there were substantial declines in mortality. in the late 1950s, the range of variation of the world standardized rates was between 4/100,000 in france and 17.8 in portugal. in the late 1980s, o ... | 1993 | 8095492 |
| helicobacter pylori and pathogenesis of ulceration. | 1993 | 8095617 | |
| helicobacter pylori and pathogenesis of ulceration. | 1993 | 8095619 | |
| h pylori in dental plaques. | 1993 | 8096286 | |
| h pylori in dental plaques. | 1993 | 8096287 | |
| detection of helicobacter pylori dna by pcr in gastrointestinal equipment. | 1993 | 8096604 | |
| helicobacter pylori: host responses in peptic ulceration. | 1993 | 8096606 | |
| gastric acid secretion and intragastric acidity: measurement in health and disease. | gastric acid secretion tests have limited use in clinical practice. for practical purposes, a ph measurement on a fasting gastric aspirate will provide strong evidence of the presence or absence of achlorhydria. tests of gastric acidity, in particular 24-h acidity studies, have provided considerable insight into normal and abnormal gastric physiology, and have largely determined the dosing regimens for the management of acid-peptic diseases. acid tests may be simple to perform, so much so that t ... | 1993 | 8097412 |
| acid pump blockers: what are their current therapeutic roles? | 1993 | 8097414 | |
| helicobacter pylori and duodenal ulcer disease: the somatostatin link? | 1993 | 8097735 | |
| detection of vacuolating toxin of helicobacter pylori in human faeces. | 1993 | 8098476 | |
| an international association between helicobacter pylori infection and gastric cancer. the eurogast study group. | gastric infection with helicobacter pylori seems to be a risk factor for gastric cancer. we have conducted a multicentre epidemiological study to investigate this relation further. our study was designed to look at the relation between the prevalence of h pylori infection and gastric cancer rates in 17 populations from 13 countries, chosen to reflect the global range of gastric cancer incidence. in each centre, about 50 males and 50 females in each of the two age groups 25-34 years and 55-64 yea ... | 1993 | 8098787 |
| categorization of clinical isolates of helicobacter pylori on the basis of restriction digest analyses of polymerase chain reaction-amplified urec genes. | restriction endonuclease analyses of a 1.1-kb polymerase chain reaction-amplified portion of the urec gene from helicobacter pylori were used to group or to differentiate 21 clinical isolates. isolates were placed into 4 groups after hindiii digestion alone, and placement was expanded into 15 groups after isolates were digested with alui and pvui. | 1993 | 8099088 |
| abdominal lymph-node granulomas and helicobacter pylori. | 1993 | 8100033 | |
| peptic ulcer disease: an update. | peptic ulcers can develop when there is an imbalance between gastric acid secretion and gastroduodenal mucosal defense. investigators are looking at the role of helicobacter pylori in the development of peptic ulcer disease; eradication of the microorganism may reduce recurrence. approved drug therapy includes h2-receptor antagonists, omeprazole, sucralfate, and antacids. recommendations for treating and counseling patients are provided. | 1993 | 8100116 |
| rapid fingerprinting of helicobacter pylori by polymerase chain reaction and restriction fragment length polymorphism analysis. | a simple and reliable technique was developed for differentiating helicobacter pylori strains by restriction fragment length polymorphism analysis of polymerase chain reaction (pcr)-amplified dnas. oligonucleotide primer pairs developed to the urease, 48-kda stress protein (htra), and 26-kda antigen-encoding genes were used to amplify fragments of the appropriate size from crude boiled cell preparations. the pcr-amplified products were digested with sau3a, haeiii, mspi, alui, mlui, hinfi, and xb ... | 1993 | 8100240 |
| differentiation between isolates of helicobacter pylori by pcr-rflp analysis of urease a and b genes and comparison with ribosomal rna gene patterns. | genetic diversity amongst 21 human gastric isolates of helicobacter pylori was investigated by polymerase chain reaction amplification and haeiii digest (restriction fragment length polymorphism) analysis of an internal 2.4-kb segment of the urease a and urease b genes. h. pylori from 11 independent individuals yielded nine distinct restriction fragment patterns but only one pattern was common to h. pylori from two individuals. by contrast, multiple isolate sets of h. pylori from two patients ea ... | 1993 | 8100546 |
| international association between helicobacter pylori and gastric cancer. | 1993 | 8100891 | |
| protection by human milk iga against helicobacter pylori infection in infancy. | 1993 | 8100892 | |
| abdominal lymph-node granulomas and helicobacter pylori. | 1993 | 8101316 | |
| abdominal lymph-node granulomas and helicobacter pylori. | 1993 | 8101317 | |
| seroconversion for helicobacter pylori. | the prevalence of helicobacter pylori antibodies increases with age, but it is unknown whether this is due to a constant rate of infection in different age groups, or whether most infection occurs in childhood. follow-up data on infection rates and the course of infection in an untreated population are scarce. we measured h pylori igg antibody concentrations in patients who were seen at our endoscopy unit between 1979 and 1983. 115 of 164 eligible patients (70%) participated in the study. h pylo ... | 1993 | 8101585 |
| acid, ulcers, and h pylori. | 1993 | 8101896 | |
| eradication of helicobacter pylori in patients with non-ulcer dyspepsia. | non-ulcer dyspepsia is an unsatisfactory term, as it describes a spectrum of conditions. the term is used for patients who have a normal upper endoscopy, macroscopically, but who have persistent upper gastrointestinal symptoms. patients with non-ulcer dyspepsia respond to a wide variety of treatments, and there is a strong placebo response. fifty per cent of these patients are shown to have helicobacter pylori present if biopsy specimens are taken at endoscopy. previous studies suggest that h. p ... | 1993 | 8102009 |
| gastric cancer and helicobacter pylori: the whispering killer? | 1993 | 8102661 | |
| malaria and the natural history of helicobacter pylori infection. | 1993 | 8102682 | |
| healing gastric malt lymphomas by eradicating h pylori? | 1993 | 8102714 | |
| the response of cells from low-grade b-cell gastric lymphomas of mucosa-associated lymphoid tissue to helicobacter pylori. | an association has been shown between colonisation of gastric mucosa by helicobacter pylori, acquisition of mucosa-associated lymphoid tissue (malt), and occurrence of primary b-cell gastric malt lymphoma. we investigated the immunological response of cells from 3 low-grade primary b-cell gastric malt lymphomas to h pylori type nctc 11637 and 12 isolates of h pylori from patients without lymphomas. after co-culture of tumour cells with bacteria, cells were examined for phenotypic evidence of act ... | 1993 | 8102718 |
| regression of primary low-grade b-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of helicobacter pylori. | certain features of primary low-grade b-cell gastric lymphoma of mucosa-associated lymphoid tissue (malt) suggest the tumour is antigen-responsive. given the close association between gastric malt lymphoma and helicobacter pylori, these organisms might be evoking the immunological response, and eradication of h pylori might inhibit the tumour. 6 patients in whom biopsies showed histological and molecular-genetic evidence of low-grade gastric b-cell malt lymphoma with h pylori infection were trea ... | 1993 | 8102719 |
| role of helicobacter pylori in the pathogenesis of complications of meckel's diverticula. | to assess the possible role of colonisation of ectopic gastric mucosa in meckel's diverticula by helicobacter pylori in causing inflammation, ulceration, perforation and bleeding. | 1993 | 8102893 |
| quality of healing in peptic ulcer disease--are h2 receptor antagonists all we need? | the rapid relief of symptoms and ulcer healing can now be achieved in most patients with peptic ulcer. histamine2 (h2) receptor antagonists, proton pump inhibitors, prostaglandin analogues, colloidal bismuth and sucralfate have all proved safe and effective for the initial treatment of peptic ulcer. however, most ulcers will recur when treatment is stopped. meta-analyses suggest a higher relapse rate after h2 antagonist therapy than that following sucralfate or bismuth. this difference has not b ... | 1993 | 8103021 |
| maintenance therapy for peptic ulcer--who needs it? | until recently, peptic ulcer disease implied lifelong susceptibility to symptomatic, asymptomatic or complicated ulcer recurrences. only about 50% of the ulcers seen endoscopically ever become symptomatic. asymptomatic ulcers appear clinically unimportant, except in the setting of aspirin (asa) or nsaid use, where they may lead without warning to fatal complications. until recently, ulcer disease could not be cured medically: no drug has been shown to prevent ulcer complications occurring in pat ... | 1993 | 8103022 |
| satellite symposium: new therapeutic approach to peptic ulcer disease. 34th annual meeting of the japanese society of gastroenterology. | 1993 | 8103024 | |
| dna fingerprints of helicobacter pylori from mouth and antrum of patients with chronic ulcer dyspepsia. | 1993 | 8103866 | |
| immunoreactive-somatostatin concentrations of the human stomach and mood state in patients with functional dyspepsia: a preliminary case-control study. | immunoreactive-somatostatin (ir-ss) concentrations of the gastric mucosa and mood state in patients with functional dyspepsia were examined. the subjects were 12 patients with upper abdominal discomfort, nausea and/or vomiting (motility disorder group) and 14 patients complaining of upper abdominal pain (ulcer-like disorder group) for more than a month without any organic upper-gastrointestinal tract disease proven by endoscopy. these patients were compared with either an age- and sex-matched gr ... | 1993 | 8104048 |
| gastric cancer and helicobacter pylori. | 1993 | 8105232 | |
| the hsp60 protein of helicobacter pylori: structure and immune response in patients with gastroduodenal diseases. | helicobacter pylori is a human pathogen that has been associated with gastritis, peptic ulcer and gastric carcinoma. the role of the direct action of h. pylori virulence factors and of the induction of autoreactive immunity in the development of chronic gastritis has not been clarified yet. here we report the cloning and molecular characterization of a gene of h. pylori coding for a protein of 58 kda, recognized by sera of patients affected by h. pylori-induced gastroduodenal diseases. this anti ... | 1993 | 8105364 |
| diarrhoeal disease: current concepts and future challenges. malnutrition and infection. | in individual children in developed countries it is possible to follow a sequence of infection of the gastrointestinal tract leading to chronic diarrhoea which, if it long persists, may in turn lead to undernutrition. both in individuals and epidemiologically in developing countries it is, by contrast, often difficult to be certain whether infection precedes under-nutrition or vice versa. chronic diarrhoea is heterogeneous and aetiology varies from community to community. unlike acute diarrhoea, ... | 1993 | 8108842 |
| animal model of human disease: lymphocytic gastritis. | gastric specimens from 102 belonging to 11 different species were reviewed. of the 11 species, only the gastric mucosa of pigs contained a large number of lymphocytes in the surface and in the foveolar epithelium (mean 82 lymphocytes/1000 epithelial cells, range 62-128 lymphocytes. the gastric specimens of the remaining 10 species revealed none or occasional lymphocytes in the surface or the foveolar epithelium. the occurrence of intraepithelial lymphocytes in the gastric mucosa of pigs mimics t ... | 1993 | 8110991 |
| inhibition of helicobacter pylori glycosulfatase activity towards human gastric sulfomucin by a gastroprotective agent, sulglycotide. | 1. a glycosulfatase activity towards human gastric sulfomucin was identified in the extracellular material elaborated by helicobacter pylori, a pathogen implicated in the etiology of gastric disease. 2. the purified enzyme displayed an apparent molecular weight of 30 kda, and exhibited maximum activity at ph 5.7 in the presence of 0.3% triton x-100 and 100 mm cacl2. 3. the h. pylori glycosulfatase activity towards human gastric sulfomucin was inhibited by a gastroprotective agent, sulglycotide. ... | 1993 | 8112521 |
| helicobacter pylori lipopolysaccharide inhibition of gastric mucosal laminin receptor: effect of sulglycotide. | 1. the effect of cell-wall lipopolysaccharide from helicobacter pylori, a bacterium implicated in the etiology of gastric disease, on the gastric mucosal laminin-receptor was investigated. 2. the receptor, isolated from gastric epithelial cell membrane by affinity chromatography on laminin-coupled sepharose, was radioiodinated and incorporated into liposomes which exhibited specific affinity towards laminin-coated surface. 3. the binding of liposomal receptor to laminin-coated surface was inhibi ... | 1993 | 8112522 |
| [the use of urea carbon 14 in breath tests as diagnostic method for helicobacter pylori infections]. | the helicobacter pylori has been indicated as a pathologic agent in the pathogenesis of antral gastritis, gastric and duodenal ulcers and probably in gastric cancer. due to the high incidence of this infection in our place, we decided to look for a diagnostic method quick to perform, sensitive, reliable and no invasive. the breath test of 14c urea, based in the production of urea by the h. pylori, represents this alternative. we have found, using does of 1 microci, a high correlation with the di ... | 1993 | 8112551 |
| helicobacter pylori in portal hypertension. | 1993 | 8114266 | |
| autogenous vaccination against helicobacter pylori. | 1993 | 8115933 | |
| helicobacter pylori: enough to give anyone an ulcer! | since the early 1980s, research into gastritis and peptic ulcer disease has been dominated by helicobacter pylori. this is a small, gram-negative spiral bacterium which inhabits the mucus layer that coats the gastric mucosa. colonisation of the human stomach by this bacterium is worldwide and, in certain continents, virtually ubiquitous. while histological gastritis is always the result, h. pylori-positive individuals are characteristically asymptomatic. transmission is thought to be via the fae ... | 1993 | 8117558 |
| helicobacter pylori infection in early and advanced gastric adenocarcinoma: a seroprevalence study in 143 taiwanese patients. | the association between gastric adenocarcinoma and helicobacter pylori infection remains controversial. a seroprevalence study of helicobacter pylori infection in 143 patients with gastric adenocarcinoma and a control group of 823 subjects randomly selected from four areas in taiwan, was carried out to elucidate the association. the overall seropositivity of helicobacter pylori in gastric adenocarcinoma patients (62.9%) was higher than in controls (54.4%), but the difference was not statisticall ... | 1993 | 8119647 |
| serum levels of pepsinogen i and gastrin in gastric carcinoma: the influence of helicobacter pylori infection and tumor characteristics. | the influence of helicobacter pylori infection on serum levels of pepsinogen i and gastrin in gastric carcinoma was investigated by simultaneous determination of serum pepsinogen i, gastrin, and igg antibodies against helicobacter pylori in 100 patients with gastric carcinoma, and in another 100 age- and sex-matched healthy controls. serum pepsinogen i level was significantly lower in gastric carcinoma than in controls (55.5 +/- 28.1 vs. 76.9 +/- 25.1 ng/ml, p < 0.005), but there was no differen ... | 1993 | 8119648 |
| [helicobacter pylori infections in various groups of patients at a general hospital and in blood donors]. | incidence of helicobacter pylori (hp) infection in inpatients of a general hospital and donors was evaluated immunologically: the serum was examined for igg antibodies to hp using enzyme immunoassay. of 354 examinees 89 had duodenal ulcer (du), 101 were healthy donors. hp infection was found prevalent in all the groups of the inpatients. cases of hp were more numerous in the gastroenterological department as compared to other departments (81.6% against 39.6%, respectively). among patients of the ... | 1993 | 8015214 |
| [diagnostic criteria of pyloric helicobacter infection in peptic ulcer]. | helicobacter pylori (hp) in 41 patients (10 with stomach ulcer and 31 with duodenum ulcer) was found in gastro-biopsies from the stomach antrum before and after the treatment. the following methods to reveal hp were used: giemsa staining, immunoperoxidase reaction with polyclonal monospecific antibodies against hp, urease rapid test. hp was also revealed in the blood serum by antibodies against hp by means of enzyme immunoassay. electron microscopy was performed in 5 patients and bacteriologic s ... | 1993 | 8122976 |
| glucose utilization and lactate production by helicobacter pylori. | the transport and incorporation of d-glucose into the human pathogen helicobacter pylori was investigated employing radioactive tracer analysis and 1h and 13c nuclear magnetic resonance spectroscopy. the bacterium was found to utilize d-glucose contrary to the accepted view that it cannot catabolize carbohydrates. under the experimental conditions employed, the rate of transport of [14c]glucose was 3.24 mmol min-1 (g protein)-1, and the rate of incorporation into the cellular mass was 1.06 mumol ... | 1993 | 8126428 |
| identification of structures containing polyphosphate in helicobacter pylori. | for the first time polyphosphate (poly p) granules have been detected in helicobacter pylori organisms colonizing the gastric antrum as well as in organisms isolated from the same tissue. poly p granules showed typical sublimation characteristics during exposure to the electron beam and chipped out of ultrathin sectioning. a prominent phosphorus signal was identified using elemental specific electron microscopy such as electron energy loss spectroscopy (eels) and was localized to at least three ... | 1993 | 8126429 |
| the automatic patient symptom monitor (apsm): a voice mail system for clinical research. | double-blind clinical trials become very tedious when symptoms are measured rather than objective laboratory and physical parameters. the standard "diary card" method is labor intensive for patients and impractical to use for more than a few weeks. in chronic relapsing disorders it would be far better for patients to record symptoms one or more times per day, at defined times, for weeks, months or even years. the automatic patient symptom monitor (apsm) is a voice processing system designed to a ... | 1993 | 8130487 |
| helicobacter pylori infection. | 1993 | 8133551 | |
| [anti-gastric antibodies and gastritis in insulin-dependent diabetes in children]. | adult patients with insulin-dependent diabetes mellitus frequently also show gastric disturbances. knowledge of the prevalence of such abnormalities in children with insulin-dependent diabetes and the predictive value of anti-gastric parietal cell antibodies in blood may be of practical importance. | 1993 | 8135606 |
| histology of the mucosa of gastric antrum and body before and after eradication of helicobacter pylori. | 1. helicobacter pylori status and the histology of the antral and oxyntic mucosa were evaluated in 25 patients with duodenal ulcer treated with a triple schedule of furazolidone, metronidazole and amoxicillin, and in 16 patients treated only with cimetidine. 2. before treatment, h. pylori was detected in all patients. one month after treatment with the antimicrobial agents, h. pylori was not found in 18 (72.0%) of 25 patients treated with the triple schedule. in the patients treated with cimetid ... | 1993 | 8136729 |
| [advances in epidemiologic study in helicobacter pylori infection]. | 1993 | 8137417 | |
| validation of a new serologic test for the detection of helicobacter pylori. | in order to determine normal ranges for positive and negative titres using a new commercially available second generation serologic elisa test for the detection of helicobacter pylori igg antibodies (malakit by biolab, limal, belgium) we investigated 560 asymptomatic pregnant women aged 20 to 44. 128 patients (22.9%) had a positive titre for helicobacter pylori. although we were able to observe an increase of the number of seropositive subjects with advancing age, a significant increase in titre ... | 1993 | 8140846 |
| [nested-polymerase chain reaction in detection of helicobacter pylori in human dental plaque]. | a nested polymerase chain reaction (n-pcr) for the specific detection of helicobacter pylori (h. pylori) was developed with two primer pairs derived from the urease gene a of h. pylori. the n-pcr was used to detect all 21 h. pylori strains, including 20 clinical isolates and 1 reference strain (nctc 14126), but failed to detect 12 other bacterial species. it was shown that the pcr assay is 100% specific. tenfold serial dilution experiments revealed that n-pcr could detect as little as 0.1 fg dna ... | 1993 | 8143193 |
| [detection of helicobacter pylori in human saliva by using nested polymerase chain reaction]. | epidemiologic studies suggest person to person spread of helicobacter pylori (h. pylori), but the exact mechanism is unknown. spread through oral secretions has been suggested, however, it has proved very difficult to grow the organism from areas outside the stomach. a nested polymerase chain reaction (n-pcr) for the specific detection of h. pylori was developed with two primer pairs (nested primers) derived from the urease gene a of h. pylori. the n-pcr could detect all 21 h. pylori strains, in ... | 1993 | 8143325 |
| spontaneous bile reflux in the elderly. | duodenogastric bile reflux is common in postoperative stomach but has been reported in intact stomachs. spontaneous bile reflux in the elderly has not been studied before. this has been assessed in dyspeptic elderly and young patients. total bile acid (tba) levels and ph were measured in the samples of fasting gastric juice. antral biopsies were taken for histological examination including helicobacter pylori identification. tba levels were significantly higher in elderly patients with gastritis ... | 1993 | 8144049 |
| [helicobacter pylori at hospital santo tomás]. | we studied the incidence of infection with helicobacter pylori in panamanians with chronic dyspepsia, gastric or duodenal ulcer, gastritis or gastric cancer. the histopathology was positive in 54 (81%) of 66 patients; the urea test was positive in 52 (82.5%) of 63 cases; the impromptu was positive in 51 (79.6) of 64 patients; the endoscopic examination was positive in 64 (82.9%) of 77 examinations. | 1993 | 8146351 |
| [helicobacter pylori: pathogenic role]. | 1993 | 8145493 | |
| comparison of urease gene primer sequences for pcr-based amplification assays in identifying the gastric pathogen helicobacter pylori. | different genomic dna samples and primer sequences were evaluated in urease (ure) gene-based pcr assays for rapid identification of helicobacter pylori. purified dna and heated (boiled) cell lysates of bacterial cultures from gastric biopsies were tested with three primer sets for unique internal urea, urea+b and urec sequences. the heated-lysates of h. pylori were quick to prepare but more frequently gave unexpected variable or negative pcr results than assays performed on purified dna, which w ... | 1993 | 8145775 |
| [spiral shaped bacteria in the human gastric biopsy]. | biopsy specimens from the gastric mucosa of 149 patients who underwent gastroduodenal endoscopy for upper gastrointestinal complaints were studied by light microscopy and culture. spiral shaped bacteria were detected in four of the specimens by smears with gram stain. the positive rate was 2.68%, but these bacteria and hp did not grow in culture. the characteristic helical morphology of the bacteria appears to be similar to that of the bacteria found in the stomach of cats and dogs. and what of ... | 1993 | 8150439 |
| [therapeutic reflections and strategies on the topic of helicobacter pylori: what, who, why?]. | 1993 | 8161613 | |
| short report: smoking habits and the acquisition of metronidazole resistance in patients with helicobacter pylori-related gastritis. | thirty-three dyspeptic patients with colonization of helicobacter pylori in the gastric antrum were treated with tripotassium dicitrate bismuthate 120 mg q.d.s. for 28 days and metronidazole 250 mg q.d.s. for 10 days starting on day 19. five weeks after cessation of this treatment regimen h. pylori was eradicated in 23 patients. in 8 of the remaining 10 patients, h. pylori had become resistant to metronidazole. in this study resistance was significantly associated with smoking habits, but not wi ... | 1993 | 8161676 |
| helicobacter pylori: microbiology of a 'slow' bacterial infection. | the bacterium helicobacter pylori lives in the gastric mucus layer of humans and induces a chronic inflammatory response that can result in both peptic ulceration and gastric neoplasms. helicobacter pylori infection can be considered as a 'slow', adaptive and autoregulating process. the mechanisms by which this slow bacterial pathogen survives and interacts with the host immune system may provide a model for other persistent mucosal pathogens. | 1993 | 8162405 |
| [clinical and pathological characteristics of helicobacter pylori-associated chronic gastritis]. | to define the clinical and pathological characteristics of helicobacter pylori-associated gastritis, 173 patients with chronic gastritis, including 99 hp-positive and 74 hp-negative patients were studied. we found that there were no significant differences between hp-positive and hp-negative patients with regard to clinical symptoms, gastric acid secretion and serum basal gastrin level, whereas the grades of chronic gastritis and active gastritis were markedly higher in hp-positive patients. 91. ... | 1993 | 8156840 |
| histology compared with chemical testing for urease for rapid detection of helicobacter pylori in gastric biopsy specimens. | gastric biopsy specimens from 283 patients with ulcer and non-ulcer dyspepsia attending five gastroenterology clinics in the northern region of the united arab emirates (uae) were tested by the agar gel test (n = 115) or the ultra-rapid endoscopy room test (n = 168) for the presence of helicobacter pylori urease. results were compared with a histological technique using the romanowsky type (diff-3) stain for detecting h pylori in both antral and body type gastric mucosa. a sensitivity of 94% and ... | 1993 | 8157765 |
| [combined therapy of duodenal ulcer associated with helicobacter pylori with electromagnetic decimeter waves and colloidal bismuth subcitrate]. | 1993 | 8154113 | |
| reinfection or recrudescence after apparently successful eradication of helicobacter pylori infection: implications for treatment of patients with duodenal ulcer disease. | helicobacter pyloris is considered to be aetiologically implicated in gastritis and peptic ulceration, since if h. pyloris infection can be eradicated the risk of subsequent ulcer relapse is markedly reduced. the rate of 'reinfection' following treatment ranges from 0% to 45%, but its origin remains controversial (reappearance of uneradicated original infection or a fresh infection). to distinguish temporary suppression of h. pylori from fresh infection we conducted a retrospective analysis of t ... | 1993 | 8171185 |
| [the rapid microscopic diagnosis of helicobacter pylori as the etiological agent of gastric and duodenal ulcers]. | 1993 | 8173217 | |
| [helicobacter pylori (h.p.) in the etiology of peptic (gastric and duodenal) ulcer]. | 1993 | 8173219 | |
| identification and characterization of a helicobacter pylori hemolysin. | 1993 | 8173790 | |
| effect of age, helicobacter pylori infection, and gastritis with atrophy on serum gastrin and gastric acid secretion in healthy men. | gastric acid secretion has been considered to decline with increasing age but this view is being re-evaluated as the importance of helicobacter pylori infection emerges. this study aimed to determine the effect of age, h pylori, and gastritis with atrophy on the serum gastrin concentration, gastric secretory volumes, and acid output in healthy, asymptomatic men. young men (mean (sd) age 22.9 (0.6) years; n = 22) were compared with old men (72.9 (1.2) years; n = 28) in respect of basal serum gast ... | 1993 | 8174948 |
| effect of eradication of helicobacter pylori on gastric juice ascorbic acid concentrations. | ascorbic acid, the reduced form of vitamin c, may protect against gastric cancer and is secreted by the normal stomach. secretion is impaired in helicobacter pylori (h pylori) associated chronic gastritis. this study examined if eradication of h pylori improves gastric juice ascorbate values. fasting gastric juice and plasma samples were collected at endoscopy from patients participating in trials of h pylori eradication for duodenal ulcer disease and intestinal metaplasia before and up to 15 mo ... | 1993 | 8174949 |
| eradicating helicobacter pylori infection lowers gastrin mediated acid secretion by two thirds in patients with duodenal ulcer. | helicobacter pylori (h pylori) raises serum gastrin but it is unclear whether this stimulates increased acid secretion. gastrin mediated acid secretion and plasma gastrin after the intravenous infusion of gastrin releasing peptide was studied in nine h pylori negative and nine h pylori positive healthy volunteers, and in 11 duodenal ulcer patients. nine of the last group were re-examined one month after eradication of h pylori. the median acid output (mmol/h) to gastrin releasing peptide (40 pmo ... | 1993 | 8174954 |
| [drug resistance of helicobacter pylori strains isolated from patients with inflammation of stomach mucous membrane and peptic ulcer of stomach and duodenum]. | twelve strains of h. pylori were tested. they were isolated from biosamples from 23 patients with stomach inflammation (16 persons) and stomach (3) and duodenum peptic ulcer. by application of solid medium dilution of mic50 and mic90-16 antibiotics and antimicrobials were tested. values of mic50 and mic90 for antibiotics from the tetracycline group were, respectively 0.25-0.5 microgram/ml and 0.12-1.0 microgram/ml. similar results were obtained with macrolide antibiotics. all strains were sensit ... | 1993 | 8189807 |
| [helicobacter pylori in mucous membrane of stomach and duodenum of patients with symptoms of ulceration and dyspepsia]. | the material consisted of samples of mucous membrane of stomach and duodenum obtained during endoscopy in patients with clinical symptoms of peptic ulcer of stomach or the duodenum or with dyspeptic problems. samples were tested for presence of h. pylori by culture on brain-heart agar supplemented with 7% of horse blood. direct test for urease production was also performed. isolated strains were identified basing on morphology of growth, gram-stained preparation, mobility of microorganism, produ ... | 1993 | 8189827 |
| a systematic overview (meta-analysis) of outcome measures in helicobacter pylori gastritis trials and functional dyspepsia. | to critically appraise the use of outcome measures in treatment trials of helicobacter pylori positive non-ulcer dyspepsia patients. | 1993 | 8171300 |
| [the etiotropic and pathogenetic treatment of patients with chronic gastritis and primary chronic gastroduodenitis]. | 120 patients with chronic gastritis and primary chronic gastroduodenitis were given a three-week course of etiopathogenetic treatment (antichelibacterial and immunocorrective drugs) that allowed to diminish the clinical, bacteriological and immune manifestations of the disease and achieve a complete cure in most patients. patients with marked chelibacteriosis revealed greater refractoriness. the authors recommend prolonged courses of treatment with alternations of etiologically directed drugs. | 1993 | 8191708 |
| [new antibacterial vaccines]. | 1993 | 8193945 | |
| [the principles of administering drug and non-drug treatment methods in peptic ulcer]. | as the result of the study optimal schemes of the ulcer disease treatment were elaborated. they include microwave resonance therapy, immunomodulatory and antibacterial drugs with regard to localisation, depth and size of the ulcerous lesion, exacerbation rate, degree of secondary immune disorders and seeding of gastric mucosa with helicobacter pylori. the treatment suggested allows to shorten the terms of ulcer cicatrization, reduces exacerbation rate and ensures clinico-endoscopic remission in ... | 1993 | 8209501 |
| [the relationship of duodenal peptic ulcer and gastroduodenitis to a chronic staphylococcal infection]. | tonsillar and pharyngeal smears revealed growth of pathogenic microorganisms, mainly of staphylococcus aureus, in 58.0 +/- 3.7% of 174 patients with duodenal ulcer and gastroduodenitis during remission or unstable remission, in 40.0 +/- 5.3% of 85 patients with other gastroenterological diseases and in 17.5 +/- 6.0% of 40 subjects constituting control group. urease activity ratio (biological marker of helicobacter pylori) was found to be approximately the same in every group of patients vs 11.1 ... | 1993 | 8209503 |
| inflammatory conditions of the stomach and duodenum. | upper gastrointestinal inflammatory processes are exceedingly common and have a wide spectrum of causes and manifestations. the broad category of acid-peptic disease incorporates the most common and important conditions. concepts of pathophysiology of gastritis and duodenitis and their relationship to ulcers and neoplasm continue to evolve. the role of infection, especially h. pylori, remains under intense investigation. the spectrum of gastroduodenal inflammation in the immunocompromised host c ... | 1993 | 8210352 |
| the fate of ingested 14c-urea in the urea breath test for helicobacter pylori infection. | the metabolic fate of the radioactive carbon in the 14c-urea breath test for helicobacter pylori was investigated in 18 subjects. after ingestion of labelled urea, breath was sampled for 24 h, and urine was collected for 3 days. subjects were designated high or low expirers on the basis of their breath counts, and this agreed well with h. pylori serologic analyses. when given 185 or 37 kbq of 14c-urea, 51% (sd = 16%, n = 11) of the label was recovered from the breath of high expirers, and 7% (sd ... | 1993 | 8210978 |
| helicobacter pylori infection and exaggerated gastrin release. effects of inflammation and progastrin processing. | helicobacter pylori infection is associated with exaggerated gastrin release. we investigated whether this abnormality was due to the bacteria or the immune response. fasting and meal-stimulated 'total' and amidated gastrin were measured in 10 h. pylori-infected volunteers before eradication therapy, after 2 and 14 days of therapy, and 4 weeks after completion of therapy. the exaggerated meal-stimulated gastrin concentration remained unchanged after 2 days of therapy, although the polymorphonucl ... | 1993 | 8210984 |
| is helicobacter pylori involved in the pathogenesis of the gastritis characteristic of pernicious anaemia? comparison between pernicious anaemia relatives and duodenal ulcer relatives. | the aim of the study was to evaluate whether helicobacter pylori could be involved in the early stages of the severe corpus atrophy that is characteristic of overt pernicious anaemia and is usually h. pylori-negative. the behaviour of h. pylori infection and chronic gastritis was studied in 159 first-degree relatives of pernicious anaemia (pa) probands and was compared with that in 137 first-degree relatives of duodenal ulcer (du) probands. du is as a rule associated with h. pylori infection. pa ... | 1993 | 8210987 |
| [a trial of modified triple therapy for the eradication of h. pylori in recurrent duodenal ulcer]. | in a prospective trial we examined the efficacy and acceptability of a modified triple therapy in h. pylori (hp)-positive patients with recurrent duodenal ulcer disease. oral administration of amoxicillin for two weeks was substituted for one single injection of intramuscular depot penicillin (benzathine penicillin g). additionally, patients were given ornidazole 500 mg tid for 14 days and 120 mg colloidal bismuth sub-citrate qid for 28 days. the patients were investigated for h. pylori coloniza ... | 1993 | 8211015 |
| [chronic recurrent abdominal pain in school children]. | the diagnostic approach of children with recurrent abdominal pain (rap) was investigated by means of a standard protocol. the protocol consisted of recently developed laboratory techniques and 'routine' investigations. in addition, all patients were subjected to an extensive psychological investigation. the main results show that in a high percentage (42%) of patients organic abnormalities could be found. particularly the small bowel seemed to be involved in the pathogenesis of the complaints. f ... | 1993 | 8211938 |
| [gastritis, ulcerous syndrome without ulcer and helicobacter pylori (250 cases)]. | 1993 | 8212332 | |
| [is there to be a renaissance of surgical treatment of ulcers?]. | medical treatment of peptic ulcer disease with h2-blockers has over the last ten years practically replaced surgical treatment of this condition, due to greater patient compliance, high effectivity and negligible side-effects. the treatment is, however, strained by the relatively high cost of medication. development of techniques for laparoscopic vagotomy, which is associated with a considerably reduced postoperative morbidity and reconvalescence as well as entailing only one to two days hospita ... | 1993 | 8212365 |
| [response to the article by fixa, komárková, nozicka: h. pylori in the etiology of ulcer disease and gastritis]. | 1993 | 8212604 | |
| [helicobacter pylori in patients with diabetes mellitus]. | the authors assessed the frequency of helicobacter pylori in diabetic patients with gastroduodenal ulceration and non-ulcerative dyspepsia. they evaluated a group of 91 hospitalized type ii diabetics which non-ulcerative dyspepsia, endoscopically confirmed ulceration of the duodenal bulbus and gastric ulceration. the control group was formed by 98 hospitalized non-diabetic subjects. between the two groups there was no difference in the frequency of helicobacter pylori in non-ulcerative dyspepsia ... | 1993 | 8212614 |