Publications

rapid detection of human cytomegalovirus and herpesvirus hominis igm antibody by the immunoperoxidase technique.	immunoglobulin m (igm) to human cytomegalovirus (cmv) and herpesvirus hominis (hvh, types 1 and 2) has been searched for in a group of patients with congenital and recent cmv and hvh infections and also in a group of patients with remote cmv and recurrent hvh infections, using the immunoperoxidase antibody technique (ipa) as compared to a technique using sucrose density gradient differential centrifugation. both techniques detected the same positive samples. high igm antibody titers (1:32-1:512) ...	1977	195911
simple mathematical deductions in the seroepidemiology of viral infections. i. herpesvirus group (herpesvirus hominis, varicella-zoster virus, cytomegalovris, epstein-barr-virus).	large samples of nonselected persons collected in south-west germnay were investigated for the prevalence of serum antibodies to the human herpesviruses hsv, vzv, cmv and ebv. according to "catalytic models", which compare the infection spread to simple chemical reactions of molecules, a mathematical approximation of the serum surveys was performed. through a new deduction of the exponential function y = k (l - e-r+) a simple way was found to estimate the annual attack rates in percent of the su ...	1977	196453
herpesvirus infection of the respiratory tract electronmicroscopic observation of the virus in cells obtained from a sputum cytology.	a case of herpesvirus infection of the respiratory tract in which the virus was seen ultrastructurally in cells obtained from a routine sputum collected for cytology studies, is presented. the method described would seem feasible for additonal studies at the ultrastructural level of cells obtained during collection of material for routine cytology of the respiratory tract. in the present case the virus particles were easily seen and characterized.	1977	196463
eczema herpeticum caused by herpesvirus type 2. a case in a patient with darier disease.	this, to our knowledge, is the first documented report of eczema herpeticum due to infection with herpesvirus hominis type 2. the virus was isolated from a patient with known darier disease who developed kaposi varicelliform eruption. recent increases in the incidence of infection with type 2 herpes simplex as well as the high frequency of recurrence with this virus make this infection of potential significance in patients with preexisting cutaneous disease.	1977	196558
in vitro studies on the mechanism of herpesvirus plaque growth inhibition by sensitized lymphocytes.	inhibition of herpesvirus plaque growth was observed when herpes simplex virus (hsv)-sensitized rabbit lymphocytes were placed in contact with an hsv-infected human foreskin monolayer. this inhibition was obtained as early as 3 h when a ratio of 6 viable lymphocytes to target cells was used, and the supernatants of these cultures also demonstrated plaque size reduction when put onto newly infected cell monolayers. interferon, which is present in this system, had no effect on hsv when tested on h ...	1977	197019
transformation of lymphocytes by herpesvirus papio.	cotton-topped (ct) or white-lipped (wl) marmoset lymphocytes were transformed in vitro with herpesvirus papio (hvp) into permanently growing lymphoblastoid cell lines (lcl). five of 9 hvp-transformed ct cell lines contained cells with antigens reacting with antibodies to epstein-barr virus (ebv) capsid antigen (vca) and/or to ebv-induced early antigens (ea). none of 12 wl lcl revealed such antigen-producing cells. cells from both groups of cultures failed to react with antibodies to the ebv-spec ...	1977	197025
techniques for typing herpesvirus hominis antibody: a comparison of inhibition of peroxidase-labelled antibody staining with inhibition of indirect haemagglutination and with microneutralisation.	a new technique based upon the inhibition of the peroxidase-labelled antibody staining (plas) has been used to type herpesvirus hominis (hvh) antibodies in four groups of human sera taken from patients with one or both types of hvh infection and in mixtures of different proportions of type 1 and type 2 antisera. the results were compared with those of the microneutralisation (mn) test and the indirect haemagglutination (iha) inhibition test. the sensitivity and specificity of the three methods w ...	1977	197239
studies of an outbreak of acute hepatitis a: ii. antibody changes to cytomegalovirus and herpersvirus.	the acute and convalescent sera from 14 schoolchildren with acute hepatitis a were tested for antibody changes to 70 viral antigens. marked decreases were noted in the levels of antibody to cytomegalovirus in 5 of the 14 children and in the levels of antibody to herpesvirus type 1 in 3. no such changes were noted in 9 sex- and age-matched healthy control children from the same classes.	1977	204739
effect of ribavirin on type 2 herpesvirus hominis (hvh/2) in vitro and in vivo.	ribavirin was found to inhibit five strains of hvh/2 tested in kb cells with the m1c range being 10-100 microgram/ml. in a mouse tail animal model, it effectively reduced hvh/2-induced lesions particularly at the peak lesion periods. ribavirin was remarkably effective when intravaginal treatment was initiated late in the infection, which suggests that it may have potential for treatment of human cutaneous infections.	1977	212976
antiviral potential of phosphonoacetic acid.	phosphonoacetate has been found to inhibit specifically the replication of herpes-viruses. a partial inhibition of vaccinia virus represents the only activity outside the herpesvirus class. the drug was found to be a specific inhibitor of the virus-induced dna polymerases. normal cellular polymerases were relatively insensitive to phosphonoacetate, resulting in low cellular toxicity. our working hypothesis is that the drug binds to the enzyme and that initiation of polynucleotide synthesis occur ...	1977	212978
inhibition of herpesvirus dna synthesis by 9-beta-d-arabinofuranosyladenine in cellular and cell-free systems.	9-beta-d-arabinofuranosyladenine 5'-triphosphate (ara-atp) is an inhibitor both of dna polymerase-alpha and -beta from noninfected rabbit kidney cells and of the dna-dependent dna polymerase induced by herpes simplex virus type 1 (strain ies). the studies were performed with partially purified enzymes, and each of the different polymerase preparations contained only one dna-dependent dna polymerase species. these enzymes were inhibited in a competitive manner. the hsv-induced dna-dependent dna p ...	1977	212980
the effect of cyclic nucleotides on virus infection.	the yield of influenza virus from infected primary chick kidney cells (pckc) was enhanced by treatment with dcamp. in addition, rapid serial passages of the virus in treated chick cells at low multiplicities did also exhibit maintenance of high virus titers. the action of dcamp upon viral replication could be reproduced in the chick cells by treatment with various agents known to increase intracellular camp levels by differing mechanisms. furthermore, an adrenergic component in the activation of ...	1977	212982
effect of a novel adenosine deaminase inhibitor (co-vidarabine, co-v) upon the antiviral activity in vitro and in vivo of vidarabine (vira-atm) for dna virus replication.	a new potent inhibitor of adenosine deaminase (co-vidarabine) was used in combination studies with adenine arabinoside (vidarabine, vira-atm) to protect this purine nucleoside from enzymatic deamination to the more weakly active metabolite, hypoxanthine arabinoside. comparing the combination to vidarabine alone, a significant increase (10-fold) of the antiviral activity of the combined drugs was observed against herpes and vaccinia viruses in tissue culture and subcutaneously, against cranial he ...	1977	212990
[chromosomes of 7 transplantable lines of macaque and pavian hematopoietic cells producing herpesvirus type ebv and oncornavirus type c].	karyotypes of su-1, su-2, kmma-1, and kmma-2 (producing oncornavirus c-type), and kmpg-1, spf-2, and spg-3 (producing hsv, a virus of ebv type) cell lines were studied in the time course. the lines were derived from hemopoietic cells of brown macaques and baboons bearing lymphomas. some of the lines had a paradiploid-pseudodiploid karyotype, another part aneuploid type. the selectivity of structural and numerical abnormalities of chromosomes 1, 9, 10, 11, 12, 13, 15, 18, and 20 was detected indi ...	1977	203114
[in vitro studies of the antiviral activity of ammonium humate against herpes simplex virus type 1 and type 2 (author's transl)].	ammonium humate, isolated from peat water, is a higher molecular polyphenolic compound with a strong antiviral activity against herpes simplex virus type 1 and type 2. three cell lines were chosen for examining the cytotoxicity of ammonium humate: rabbit kidney primary cells, hep-2- and fl-cells. as the light microscopic examination of both, the monolayers and the stained cover-glass cultures, revealed, concentrations of up to 5 microgram/ml ammonium humate can be used without hesitation for rab ...	1977	203143
[severe ocular manifestations attributed to a type 2 herpesvirus].		1977	203898
the isolation of bovid herpesvirus 2 from cattle in zambia.		1977	204098
an in vivo and in vitro study of infectious laryngotracheitis virus in chicken leukocytes.	infectious laryngotracheitis (ilt) virus, an avian herpesvirus, caused an infection in chickens that was followed by leukopenia due to a decrease in the number of circulating lymphocytes. viral synthesis in leukocytes in cell cultures was evident by specific and progressive viral antigens in the nuclei of infected leukocytes as shown by fluorescent-antibody technique and by the formation of multinucleated giant cells, typical of the herpesviruses. in addition, viral multiplication was observed i ...	1977	204276
dual virus maturation of both pathogenic and apathogenic marek's disease herpesvirus (mdhv) in the feather follicles of dually infected chickens.	infectious cell-free viruses of both pathogenic and apathogenic marek's disease herpesvirus (mdhv) were detected in feather-tip extracts of chickens dually infected with both mdhv isolants either by inoculation or by contact exposure. this indicated concurrent viral maturation of both pathogenic and apathogenic mdhv isolants in the feather-follicle epithelium, resulting in possible double shedding of the two isolants.	1977	204277
[diagnosis of recurrent herpesvirus infection by means of viral precipitin studies].		1977	218265
[recurrent herpesvirus in the state of rio de janeiro].		1977	218266
maternal viral infection with adverse results: cytomegalovirus and herpesvirus.		1977	218305
genital herpesvirus infection in a prepubertal girl.	an episode of acute vulvovaginitis which was found to be due to herpesvirus is described in an eight-year-old girl. the significance of such infections is discussed.	1977	843482
efficacy of 5,6-dihydro-5-azathymidine against cutaneous herpes simplex virus in hairless mice.	5,6-dihydro-5-azathymidine, administered subcutaneously, was active both prophylactically and therapeutically against cutaneous herpesvirus infection of hairless mice. activity was comparable to that obtained with adenine arabinoside.	1977	856033
neuroretinitis associated with herpes simplex encephalitis in an adult.	a 48-year-old man who died of herpes simplex encephalitis had a bilateral papillitis at autopsy. intranuclear inclusion bodies were especially numerous within the ganglion cells and inner nuclear layer of the macula and consisted of typical virions by electron microscopy. contiguous spread from the brain to the eyes may have occurred via the optic nerves. clinically, the disk and retinal changes were misinterpreted as being caused by papilledema. papillitis should be included in the differential ...	1977	868948
failure of type 1 herpesvirus to develop resistance to ribavirin.	exposure (10 passages) of type 1 herpesvirus to ribavirin or idoxuridine in vero cells results in resistance to idoxuridine, but not to ribavirin.	1977	883814
morphogenic studies of herpesvirus and oncornavirus from leukemic and normal guinea pigs.		1977	885267
malignant transformation of rat embryo cells by a herpesvirus isolated from l2c guinea pig leukemia.		1977	898672
effect of pregnancy hormones on herpesvirus and other deoxyribonucleic acid viruses.	clinical impressions and observations of genital herpesvirus infections indicate that lesions are more persistent and more severe during pregnancy. several explanations are possible: an altered immune state, increased vascularity and blood flow, and/or increased viral infectivity due to increase in one or more hormones during pregnancy. studies presented here were directed toward investigating the latter possibility. herpesvirus, type 2, isolated from a genital lesion was titrated in wi-38 cells ...	1977	900179
disseminated herpesvirus hominis 2 infection following drug overdose.	fatal disseminated herpesvirus hominis type 2 infection developed in a 24-year-old woman with psychiatric disease. the primary site of virus entry appeared to be the upper respiratory tract, although the cervix and anus could have been primary sites. dissemination of infection was facilitated by steroid therapy. an endotracheal tube may have increased spread to the lower respiratory tract and an intrauterine device may have aided spread to the uterus. intranuclear inclusion body-bearing cells in ...	1977	901088
studies of turkey herpesvirus viremia in two strains of vaccinated chickens strain difference and effects of vaccine dose.	turkey herpesvirus (hvt) viremia was studied at 3-week intervals through 21 weeks of age in individual chickens of experimental (wsu-vs) and commercial strains (c-wl) of white leghorns vaccinated with graded doses of hvt. hvt viremia was consistently detectable in all wsu-vs birds through 21 weeks postvaccination (pv) regardless of vaccine dose employed, whereas the viremia could not be detected in some of the c-wl birds 9 to 15 weeks pv and thereafter. c-wl birds that lost detectable viremia re ...	1977	907581
herpesvirus-like particles in tumor cells of breast muscle of chickens with marek's disease.	tumors of the breast musculature of 4 chickens with marek's disease were examined by light and electron microscopy. by light microscopy, tumors were composed of lymphoid cells which had infiltrated and separated bundles of muscle fibers. by electron microscopy, there was margination of chromatin and duplication of the inner nuclear membrane in almost all neoplastic cells of breast tumors of all 4 chickens. in addition, in one chicken the nuclei of tumor cells contained naked herpesvirus-like par ...	1977	907582
efficacy of herpesvirus of turkeys vaccine against challenge with marek's disease tumor cells.	tests were made of the effectiveness of herpesvirus of turkeys (hvt) vaccine in preventing tumorigenesis following challenge with a neoplastically transformed marek's disease tumor cell line (msb-1). hvt vaccine prevented tumors due to msb-1 inoculation whereas 21.4% of unvaccinated controls had tumors. the results support, but do not prove, the theory that hvt acts through enhancement of cell-mediated immunity against mdv-transformed cells. the drawbacks of using msb-1 cells in this experiment ...	1977	907584
studies on cytopathogenic viruses from cats with respiratory infections. iv. properties of hemagglutinin in feline herpesvirus suspensions and receptors on feline erythrocytes.		1977	916471
treatment of genital infections with herpesvirus hominis.		1977	579479
proventriculitis, "nakanuke" and reticuloendotheliosis in chickens following vaccination with herpesvirus of turkeys (hvt)		1977	588186
how reliable is the morphological diagnosis of penile ulcerations?	material from 100 consecutive men who presented with penile ulcerations was tested for a variety of microorganisms. fifty-one patients had microorganisms identified that were considered primary pathogens. the laboratory data were compared with the clinical diagnoses and the diagnostic accuracy and index of suspicion calculated. the diagnostic accuracy for lesions due to treponema pallidum was 77.8%, herpesvirus hominis 62.9% and haemophilis ducreyi 33.3%, whereas the indexes of suspicion were 88 ...	1977	594859
vesicular lesions in adults due to echovirus 11 infections.	echovirus 11 was recovered from vesicular lesions in two adults. patient 1 had a severe disseminated vesicular exanthem. patient 2 had a mild vesicular enanthem. both were clinically suspected of having herpesvirus hominis lesions. serologic studies indicate that these viruses were similar to each other and also to the "u" prime strain.	1977	596902
application of the cell-free turkey herpesvirus vaccine by the aerosol route for the prevention of marek's disease in chickens.	in field trials approximately 300,000 birds were vaccinated against marek's disease (md) by aerosol spray with 1,000 to 5,000 pfu of cell-free hvt vaccine per chick. chicks were sprayed in the trays of the hatchers which still contained dust and down after hatching. prior to spraying, the incoming and outgoing air ducts were closed. the chicks were sprayed for 12--15 min. with hvt in 250 to 300 ml. of diluent, and after completion of spraying the chicks remained in contact with the aerosol for a ...	1977	605103
rational design of arabinosyl nucleosides as antitumor and antiviral agents.	the rational design of antitumor and antiviral agents must ultimately take advantage of biochemical differences between normal host cells and transformed cells. the initial experiments must be performed with subcellular or cellular model systems. for the studies with arabinosyl nucleosides we have chosen those enzyme systems, synthesizing dna and rna; being precursor analogues, the different arabinosyl nucleosides have been added in the triphosphate state to the different dna- and rna polymerase ...	1977	612702
isolation and characterisation of herpes virus from turkeys.	turkey herpesvirus (hvt) was isolated from the kidneys of 6 of 8 turkey poults from two flocks. the isolates were identified by syncytial-type of cytopathology, inhibition of plaque formation by 5-bromodeoxyuridine, formation of cowdry type a intranuclear inclusions in cell cultures, and presence of herpes-type virions in negatively stained preparations and thin sections of infected cell cultures. one of these isolates inoculated into chickens proved apathogenic over an observation period of 10 ...	1977	614022
herpes simplex keratitis.	this article reviews the current concepts for the diagnosis and treatment of herpes simplex keratitis and its complications, discussing characteristics of the virus, the prevalence of the disease, chemical and clinical differentiation between types i and ii herpesvirus hominis, and the many clinical presentations of type i disease. the antiviral agents commonly in use are reviewed, covering the historical development of the drugs, indications for their use and the associated toxic and untoward r ...	1977	402036
isolation of virus-free herpesvirus saimiri antigen-positive plasma membrane vesicles.	experiments were undertaken to determine whether virus-free, antigen-positive plasma membrane vesicles could be isolated from owl monkey kidney cells infected with herpesvirus saimiri. the results demonstrate that vesicles can be produced by using a vesiculation fluid containing 25 mm formaldehyde/2 mm dithiothreitol. electron microscopy revealed that these vesicles were free of detectable virus particles. vesicles prepared from the infected cells contained virus-induced membrane antigens as sho ...	1977	407579
disodium phosphonoacetate in cream base as a possible topical treatment for skin lesions of herpes simplex virus in cebus monkeys.	disodium phosphonoacetate (paa) in a cream-ointment base was applied to herpesvirus skin lesions on the genitalia of cebus monkeys. the lesions had been produced by the intradermal injection of herpes simplex virus type 2. concentrations of 0.2, 2, and 5% paa were used. liberal application of paa at concentrations of 2 and 5% proved extremely irritating and produced extensive, severe lesions over the treated area. the 2% paa, when applied carefully to the lesion area, proved less irritating, but ...	1977	411417
disseminated herpesvirus hominis infection in a child with acute leukemia.		1977	266071
synergistic effects of antiviral agents and humoral antibodies in experimental herpesvirus hominis encephalitis.	experimental herpesvirus hominis encephalitis in 3-week-old swiss mice was utilized to evaluate the antiviral effects of adenine arabinoside (ara-a), phosphonacetic acid (paa), and humoral antibodies to h. hominis (hig). administration of ara-a, paa, or hig during the early phase of infection reduced the mortality rate of h. hominis encephalitis in mice. combined administration of humoral antibodies with an antiviral agent (ara-a or paa) resulted in an enhanced protection, accompanied by a decre ...	1977	280140
relative potencies of anti-herpes compounds.	assessment of the relative potencies of compounds that inhibit the multiplication of herpesvirus is rendered difficult by the fact that they have been investigated by different workers who were not using comparable test systems. the relative and absolute potencies of idoxuridine, cytarabine, vidarabine, trifluorothymidine, and ara-dap have therefore been evaluated by plaque inhibition, plaque reduction, and yield reduction tests, the most satisfactory dose-response lines being obtained by plaque ...	1977	280147
cutaneous herpes simplex virus infection of guinea pigs as a model for antiviral chemotherapy.	the kinetics of herpesvirus hominis (type 1) replication and lesion development in guinea pig skin were determined. the data indicate that lesion scores did not always reflect virus content. virus replication was detected prior to appearance of lesions and maximum virus content preceded maximum lesion score. lesions resolved slowly while virus content declined rapidly to an undetectable level. the utility of the guinea pig skin-herpesvirus model for the evaluation of ara-a and kethoxal was studi ...	1977	280151
frequency of occurrence of viruses associated with respiratory tract disease of cattle in oklahoma: serologic survey for bovine herpesvirus dn599.	serum samples from 351 oklahoma cattle were tested for antibodies to dn599 virus by the indirect fluorescent antibody test. seven cattle (approximately 2%) were seropositive for this virus.	1977	334002
effect of interferon on systemic herpesvirus infections.	the studies reviewed here are encouraging in that hsv is moderately sensitive to the action of interferon and that infections in experimental animals clearly may be altered by exogenous interferon and interferon inducers. on the other hand it is apparent that the potential of this approach to treatment of herpesvirus infections is limited by the levels of interferon that can be passively administered or induced, the development of hyporeactivity which prevents maintaining high levels of interfer ...	1977	358468
[investigations on the mode of transmission of the herpesvirus of turkeys in vitro].	fluorescent microscopic and immuno-histochemical methods, and cytochalasin b, were used to investigate the mode of transmission of the herpesvirus of turkeys in vitro. the results obtained indicated that a paramount requirement for the transmission of the herpesvirus of turkeys in vitro is the formation of virus-containing cytoplasmic protrusions. the addition of cytochalasin b to the cell culture medium prevented the formation of plaques. however, this effect was reversible.	1977	18770310
cross-protection between jmv marek's disease-derived tumour transplant, marek's disease and turkey herpesviruses.	cross-protection tests were conducted using attenuated jmv (jmv-a) marek's disease-derived lymphoblasts, glutaraldehyde-treated jmv tumour cells, attenuated marek's disease virus (mdv, strain hprs-16/att) and turkey herpesvirus (hvt, strain fc126) as vaccines, and virulent jmv and mdv (hprs-16) for challenge. the jmv and jmv-a preparations were free of mdv, leukosis and reticuloendotheliosis viruses. vaccination of chickens with attenuated mdv or with hvt provided good protection against both jm ...	1977	18770345
quantitative pathogenicity of marek's disease virus and vaccine virus strains in chickens: macroscopical aspects.	two virulent strains (jm and k) and one vaccine strain (cvi 988) of marek's disease virus (mdv), together with two vaccine strains of the herpesvirus of turkeys (hvt) (fc 126 and pb-thv 1), all in the cell-associated state, were administered intramuscularly at 3.7 log tcid50 per dose to day-old spf white leghorn chickens. a control group of chicks received uninfected cells. the pathological parameters studied were onset and duration of clinical symptoms, mortality, bird weight and macroscopical ...	1978	18770360
[potency tests with hvt-, mhv- and jmv vaccines against marek's disease].	turkey herpesvirus (hvt)(fc 126) vaccine made in w. germany, marek's herpesvirus (mhv) (cvi 988) vaccine used in the netherlands and experimental jmv vaccine were tested in laboratory and field trials for protection against marek's disease. the tests were carried out with 780 spf chicks and 3200 commercial white leghorn chicks (with maternally derived antibodies to hvt and mhv). there were no differences in potency of hvt- and mhv vaccines. both vaccines showed increased protection with an incre ...	1978	18770372
transient effect of cyclophosphamide on vaccinal immunity to marek's disease.	cyclophosphamide treatment of chicks abrogated the induction of immunity against marek's disease (md) by the herpesvirus of turkeys, but immunity eventually developed if a sufficient interval was allowed to elapse between vaccination and challenge. vaccinated, cyclophosphamide-treated chicks showed severe suppression of antibody and immunoglobulin production even when immunity to md was present, suggesting that resistance was not mediated by humoral immunity. bursa and thymus weights of chicks w ...	1978	18770381
contagious paralysis of pigeons.	a disease affecting domestic pigeons characterised by marked contagiousness, high mortality and rapidly progressing paralysis of the extremities is reported. gross and microscopical findings in naturally affected pigeons are given. a viral agent was isolated and found to be a herpesvirus. reproduction of the disease in domestic pigeons with the isolated virus and its reisolation suggests it may be causally related to the condition.	1978	18770416
herpesvirus salmonis: characterization of a new pathogen of rainbow trout.	a new agent, provisionally designated herpesvirus salmonis, was isolated from post-spawning rainbow trout (salmo gairdneri) and studied primarily in the rtg-2 rainbow trout cell line. infection of rtg-2 cells resulted in the formation of syncytia and cowdry type a intranuclear inclusions. replication occurred regularly at 5 and 10 degrees c, but was inconsistent at 15 degrees c, largely inhibited at 0 degrees c, and completely inhibited at 20 degrees c or higher. the virus was acid, heat, ether, ...	1978	16789171
isolation and partial characterization of an antibody enhancing factor from leukaemic owl monkey cell cultures.	herpesvirus saimiri inoculated into owl monkeys (aotus trivirgatus) causes leukaemia and lymphoma. peripheral lymphocytes from leukaemic monkeys grown in culture are predominantly t lymphocytes. the supernatants from these cultures contain a factor which enhances the antibody response of murine b cells to sheep red blood cells (srbc). the factor has been partially characterized by ammonium sulphate precipitation, deae-chromatography, gel filtration over sephadex g-150 and disc-gel electrophores ...	1978	342395
a double-blind, controlled trial of levamisole in the treatment of recurrent herpes labialis.	a double-blind, controlled trial of levamisole in the prevention and treatment of recurrent cold sores was performed. forty-eight subjects received levamisole in a dosage of 2.5 mg/kg on two consecutive days each week for six months. the 51 control subjects were given a placebo identical to the drug in appearance. both groups were given the same instructions. nineteen subjects receiving levamisole and eight receiving placebo withdrew during the six months of the study. there were no significant ...	1978	351073
levamisole and the treatment of herpesvirus hominis infections. a case report.	the successful treatment with levamisole of 3 categories of herpesvirus hominis infection is described. a fourth category of patients infected with vulval condylomata acuminata were unsuccessfully treated with levamisole. the dosage regimen is discussed. the most dramatic feature was the relief of the severe pain encountered in the acute cases. levamisole has also prevented further attacks to date. there is no doubt that levamisole has a definite place in the treatment of h. hominis infections.	1978	354039
[immunomorphological changes in chicks vaccinated against marek's disease with herpesvirus sz-1].		1978	219588
effectiveness of cell-free or cell-associated turkey herpesvirus vaccine against marek's disease in chickens as influenced by maternal antibody, vaccine dose, and time of exposure to marek's disease virus.		1978	219826
in vitro inactivation of cell-free marek's disease herpesvirus by immune peripheral blood lymphocytes.	the effect of peripheral blood lymphocytes (pbl) on cell-free marek's disease virus (mdv) was studied in vitro in pbl from intact or embryonal bursectomized (bx) chicks infected with the apathogenic sb-1 isolate of mdv. the pbl were harvested purified and were mixed, 200 or 2,000 to 1, with cell-free ga-5 of mdv. virus survival was assayed after incubation for 1 hour at 36 c by the standard assay for cell-free mdv. pbl from intact but not bx chickens were able to inactivate virus. when the effec ...	1978	219833
[serologic methods for the overall diagnosis of bovine herpes mamillitis].	developed were methods of seroneutralization, agar gel precipitation, and complement-fixation test (cft) for the complex diagnosis of herpes mamillitis of herpes mamillitis in cattle. an agreement was found between the results obtained with the use of each method. highest sensitivity and specificity possessed the seroneutralization reaction with which a highest percent of positively reacting sera was revealed (18.6). however, the cft method could preferably be applied in mass investigations as i ...	1978	217144
bovine herpesvirus 1--infection of the upper alimentary tract of cattle and its association with a severe mortality.		1978	223538
changes in the lymphoid organs of mice after a short treatment with diphenylhydantoin and inoculation with an herpesvirus subtype.		1978	223608
serodiagnosis of herpesvirus infection in primates.	the presence of herpesviruses in various animal tissues used for vaccine production is of importance, inasmuch as these viruses may go unrecognized, residing in latent form. of greatest concern is herpesvirus simiae (b virus) present in the majority of macaca species, one of the more extensively used laboratory nonhuman primates. the close antigenic relationship of b virus to human herpes strains (h. hominis) and sa8 (a baboon herpesvirus) makes serologic differentiation extremely difficult, but ...	1978	223911
episomal viral dna in herpesvirus saimiri-transformed lymphoid cell lines.	structural analysis of episomal viral genomes from two herpesvirus saimiri (hvs)-transformed tumour cell lines (no. 1670 and 70n2) showed that both types of episomes have a higher molecular weight than linear virion dna. the arrangement of unique (l) and repetitive (h) dna in no. 1670 episomes was studied by partial denaturation mapping. part of the l-sequences present in linear virion dna was found to be missing, part was found to be duplicated in the episomes. the episomal l-dna regions were c ...	1978	221324
herpesvirus papio: state of viral dna in baboon lymphoblastoid cell lines.	baboon lymphoblastoid cell lines (lcl) transformed with herpesvirus papio were evaluated for the state of hvp dna in the cells by caesium chloride density-gradient centrifugation and dna-crna filter hybridization. five hvp producer cultures and one non-producer culture were studied and non-integrated and integrated hvp dna were detected in all producer cultures whereas only integrated hvp dna could be demonstrated in the non-producer lcl. non-integrated hvp dna had a density of 1.715--1.716 g/cm ...	1978	221325
altered biological and biochemical properties of a phosphonoacetate-resistant mutant of herpesvirus of turkeys.	a phosphonoacetate (pa)-resistant mutant of the herpesvirus of turkeys (hvt) was isolated and characterized. the mutant (hvtpa) replicates in growth medium containing 300 microgram/ml of pa and shows in vitro temperature sensitivity at 41 degrees c (its 37 degrees c/41 degrees c efficiency of replication is about 5). hvtpa replicates poorly in chickens and fails to provide complete protection against mdv challenge. the hvtpa-induced dna polymerase has an apparent inhibition constant for pa 10 ti ...	1978	221331
human herpesvirus 1 as a model of regulation of herpesvirus macromolecular metabolism: a review.		1978	221332
identification and partial purification of two ebv-associated dna polymerases.	virally induced dna polymerases have been demonstrated in cells infected with a variety of herpesviruses. these include herpes simplex virus (weissbach et al., 1973), marek's disease virus (boezi et al., 1974), equine herpesvirus (allen et al., 1977), and cytomegalovirus (huang, 1975a). recently a new iododeoxyuridine (iudr)-induced intracellular dna polymerase in an epstein-barr virus (ebv)-producing hybrid cell line has also been reported (miller et al., 1977). we present evidence that there a ...	1978	221345
herpesvirus production by ultraviolet-irradiated human skin cells: a marker of repair.		1978	221346
oncogenic transformation of non-permissive murine cells by viable equine herpesvirus type 1 (ehv-1) and ehv-1 dna.	primary cultures of balb/c mouse embryo fibroblasts infected with as much as 100 pfu per cell of ehv-1 do not exhibit cytopathology or synthesize detectable amounts of ehv-1 specific rna, dna, or infectious virus. addition of 1--2 microgram of non-fragmented ehv-1 dna as a co-precipitate with calcium phosphate to monolayers of such non-permissive mouse cells resulted in the appearance, after 4--6 weeks, of foci of piled-up, morphologically altered cells. cell lines established from such transfor ...	1978	221355
enhanced efficiency of transfection of hsv dna in hsv-1 dna-transformed hamster cells.	the efficiency of transfection, i.e., the number of plaques per microgram of dna, was compared for herpes simplex virus (hsv) type 1 and type 2, and herpesvirus eidolon (antigenically unrelated to hsv) dnas in hsv dna-transformed cells (eh/a44) and control hamster cells (eht). the efficiency of transfection of hsv-1 and hsv-2 dnas was significantly higher in eh/a44 cells than in eht cells, showing that an early step in hsv infection was involved in the partial resistance of hsv dna-transformed c ...	1978	221357
characterization of the replicative structures of the dna of a herpesvirus (pseudorabies).	the replication of prv dna occurs in two phases, early and late. during the early stages of infection newly synthesized dna is associated with molecules sedimenting with an s-value up to two-fold greater than that of mature viral dna. these molecules represent unit-size linear or circular molecules, as well as small concatemers in the process of replication. initiation of replication occurs at a site situated 20 micron from one of the ends as well as at or near the end of the molecules. at later ...	1978	221363
arabinosylthymine: in vivo effectiveness in a systemic herpesvirus infection.		1978	221367
potential for immunization against herpesvirus infections with plasma membrane vesicles.	virus-free, membrane antigen (ma)-positive plasma membrane vesicles produced from herpesvirus saimiri-infected owl monkey cells were used as immunogens in cotton-top marmosets. neutralizing antibodies as well as antibodies to ma and hvs-induced la were induced following immunization of marmosets with these vesicles. preliminary findings demonstrated that immunized marmosets were significantly less susceptible to tumour induction by hvs than control animals.	1978	221369
provisional classification of herpesviruses: herpesvirus study group of the international committee for the nomenclature of viruses.		1978	221375
achievements, priorities and needs in the lucké tumour herpesvirus field.		1978	221378
oncogenesis and herpesviruses iii. part 2: cell-virus interactions, host response to herpesvirus infection and associated tumours, role of co-factors.		1978	221380
pronephric tumour cell lines from herpesvirus-transformed cells.	pronephric tumor cell lines have been established from tumours induced after inoculation of embryos with herpesvirus cultivated in vitro. neoplastic properties of the lines are characterized.	1978	221384
the immunology of primary and recurrent herpesvirus infection: an overview.		1978	221390
persistent, chronic, and latent infections by herpesvirus: a review.		1978	221391
comparison of humoral and cell-mediated responses and virus markers in herpesvirus-associated lymphomas: a review.		1978	221406
prospects for control of herpesvirus-related diseases: a review.		1978	221415
vaccination against diseases associated with herpesvirus infections in animals: a review.	an account is presented of the development and use of herpesvirus vaccines in domestic animals, with particular reference to those viruses causing cytolytic rather than oncogenic infections. the chief infections covered are aujeszky's disease (ad or pseudorabies), infectious bovine rhinotracheitis (ibr) and equine rhinopneumonitis (equine abortion; ehv-1). others mentioned are feline viral rhinotracheitis and malignant catarrhal fever of cattle. both live-modified and inactivated vaccines are wi ...	1978	221416
the interaction between herpesvirus and oncornavirus of guineapigs: in vitro and in vivo studies.	in vitro, cultured guineapig doubly infected with both guineapig herpesvirus (gphlv) and guineapig oncornavirus (gpov) revealed pseudotype virus particles with oncornavirus morphology coated with gphlv antigen as detected by immunoferritin electron microscopy. in vivo, infection of hartley guineapigs with both gphlv and gpov induced hyperplasia in lymph-nodes in a higher percentage of animals than in those that received only one virus type. in addition, experimental gphlv infection of strain 2 g ...	1978	221417
effect of ara-t on the replication of herpes simplex virus, varicella-zoster virus and cytomegalovirus.	the thymidine analogue, 1-beta-arabinofuranosylthymine (ara-t), has previously been found to selectively inhibit herpes simplex virus (hsv) replication. at a relatively non-toxic concentration (50 microgram/ml), ara-t reduced hsv yields by a factor of 10,000-100,000. ara-t was also effective in inhibiting the replication of variecella-zoster virus (vzv) in vitro in human embryo fibroblasts, completely preventing vzv-specific cytopathic effects (cpe). ara-t reduced the cell-free virus and plaque- ...	1978	221418
rising perinatal infections. herpesvirus hominis type 2 in women and newborns.		1978	414034
a multicentered study of lysine therapy in herpes simplex infection.	lysine appears to suppress the clinical manifestations of herpesvirus infection. 45 patients with frequently recurring herpes infection were given 312-1,200 mg of lysine daily in single or multiple doses. the clinical results demonstrated a beneficial effect from supplementary lysine in accelerating recovery from herpes simplex infection and suppressing recurrence. tissue culture studies have demonstrated an enhancing effect on viral replication when the amino acid ratio of arginine to lysine fa ...	1978	640102
antibodies to herpesvirus type 1 and type 2 among japanese cervical cancer patients.	antibodies to herpesvirus type 1 and type 2 were examined in 69 japanese females with cancer of uterine cervix, which included cases of cervical dysplasia (7 cases), carcinoma in situ (9 cases), and invasive carcinoma (53 cases), and 112 matched controls. the presence of antibodies to type 2 virus was 42% in cervical dysplasia, 11% in carcinoma in situ, and 28% in invasive carcinoma, while such was 15% in matched controls. mean antibody titer in log10 was 2.12 to type 1 and 1.65 to type 2 in wom ...	1978	640320
a bovine herpesvirus isolated from sheep.	a viral agent was isolated from the trachea of a lamb that was suffering from a respiratory disorder. the physical and chemical properties of the isolates are characteristic of the herpesvirus group. it contains dna in its virion, is ether sensitive, acid labile at ph 3.0 and heat labile at 56 degrees c after five minutes. the cytopathology observed provided further evidence of a herpesvirus isolate. the neutralization of the infectivity of the isolate with antiserum to bovine herpesvirus 1 is e ...	1978	647461
induction of delayed hypersensitivity to turkey herpesvirus in fowls.	delayed hypersensitivity, as determined by the wattle skin reaction, to turkey herpesvirus developed in chickens sensitised with the infected cell antigen. a significant increase in skin thickness occurred in the sensitised wattles as compared with the controls.	1978	653123
treatment of cutaneous herpesvirus hominis type 2 infection with 8-methoxypsoralen and long-wave ultraviolet light in guinea pigs.	treatment of cutaneous herpesvirus hominis type 2 infection in albino guinea pigs with 8-methoxypsoralen plus long-wave ultraviolet light was evaluated by clinical assessment and quantitative viral cultures. there was a statistically significant difference between the treated animals and the controls in relation to vesicular development, rate of healing, and viral titers. the treatment was effective after the appearance of lesions, when viral multiplication has already begun.	1978	659920
a biological perspective of slow virus infection and chronic disease.	sequential events characterize the interaction of viruses with parenchymal cells, and acute lytic infections of tissues and organs have broad biological attributes. a knowledge of these permits a keener understanding of persistent, intermittent herpesvirus infections and persistent, continuous respiratory virus infections. in addition to unique biochemical mechanisms which may permit the latter chronic infections to evolve, the roles of defective and mutant strains of virus, viral interference, ...	1978	664641
herpesvirus hominis endometritis in a young woman wearing an intrauterine contraceptive device.		1978	665740
[disseminated herpesvirus hominis infection. a case report].	a case of disseminated herpesvirus hominis (type i) in a 23-year-old white man with widespread eczema is reported. the grave prognosis of this disease is stressed.	1978	675412
pathogenicity of equine herpesvirus: in vivo persistence in equine tissue macrophages of herpesviuus type 2 detected in monolayer macrophage cell culture.	equine macrophages from the mammary glands of a yearling filly and an 18-year-old barren nonlactatind mare formed cell monolayers in continuous cultures. there was absence of viral cytopathic effect (cpe) in early cell culture passages. the cells from the early cell culture passages having no cpe failed to show evidence of virus or viral antigen by electron microscopic and immunofluorescence studies. foci of cpe first appeared in the monolayer cell cultures from the filly and the mare in the 3rd ...	1978	697153
frequency of anti-ag-4 antibody in patients with uterine cervical cancer and controls.	association of herpesvirus type-2 (hsv-2) with cervical cancer was studied from seroepidemiological viewpoint, using early antigen induced in hep-2 cells by hsv-2 4 hr after infection (ag-4). the ag-4 antibody was assayed by the microquantitative complement fixation method. antibody to ag-4 was respectively detected in 47% and 14% of cervical cancer patients and controls (p less than 0.001). there was a tendency of the antibody prevalence to increase with clinical stage. there was no correlation ...	1978	710808