Publications

avirulent mutants of the cvs strain of rabies virus.	two avirulent mutants of the cvs strain of rabies virus have been isolated on the basis of their loss of sensitivity to antiglycoprotein neutralizing monoclonal antibodies. with the exception of virulence, both retain general characteristics of the cvs strain of the rabies virus. after inoculation, they induce a strong and rapid immune response in adult mice. in this respect, however, they are quite different from the parental cvs strain. surviving mice are protected against intramuscular challe ...	1982	7128059
[role of interferon in rabies immunity].	cell cultured rabies vaccines, usually induce a good production of interferon. a comparative study shows that vaccines from primary explantation cell cultures are better interferon inducers. taking into account the importance of this induction in rabies vaccination, a study showing the role of leucocyte interferon (alpha-type) is achieved. results show that leucocyte interferon (originating from the red cross, osaka, japan and institut pasteur production, paris) inhibits the formation of fluores ...	1982	7128060
[haemagglutination inhibition test: improvements, limits and advantages of the method. comparison with neutralization test].	in this study, we report some technical improvements which enable us to envisage wider use of the haemagglutination test and haemagglutination inhibition of the rabies virus. moderated trypsination of sensitive red blood cells and their counting are important parameters. an interesting application of the test was the haemagglutination competition enabling the amount of soluble glycoprotein (obtained during the fractionating of the virus components) to be evaluated. from antibody kinetics of vacc ...	1982	7128064
small mammal studies in a sad baiting area.	studies in the laboratory or in the field on the effect of sad virus on small rodents are reported. laboratory experiments by oral inoculation of sad strain in a wide variety of small mammals led to the conclusion that spontaneous sad transmission from rodent to rodent is a rare event. field experiments were conducted by live-trapping, sacrifice and analysis of 192 apodemus sylvaticus, 28 clethrionomys glareolus and 48 crocidura russula. they gave no indication that sad virus became established ...	1982	7128065
safety tests with flury hep strain 675 in wild-living european mammals.	for the evaluation of residual pathogenicity of flury hep strain 675, the vaccinal virus was orally administered to 207 animals belonging to 15 wild-living and 1 domestic species. rabies virus antigen could be demonstrated by fa method in 20 animals. reisolation of the virus was possible from 23 animals within the first two weeks after application, the titres being very low. during the observation period of 100 days no symptoms of rabies could be observed in the animals tested.	1982	7128066
effectivity of oral vaccination of foxes against rabies with flury hep strain 675.	a group of 14 adult foxes was orally vaccinated with 2 ml flury hep strain 675, titre 10(8.2 tcid50. each fox seroconverted neutralizing antibody titres ranging between 1:40 and 1:640. these foxes survived an intramuscular challenge with 8000 mouse ld50 pathogenic rabies virus, whereas six out of seven unprotected control foxes died within 28 days. this study was accompanied by virus isolation, fluorescence microscopic examination and neutralization tests.	1982	7128067
[evaluation of an experimental rabies vaccine by the oral and intestinal route with inactivated vaccines, concentrated or non-concentrated].	application of beta-propiolactone inactivated rabies vaccine prepared in bovine embryo kidney cells, concentrated or non concentrated, by intestinal or oral route resulted in antibody production in rats and cats. 80-100% of vaccinated rats were protected against challenge with street rabies virus. the same vaccines (lyophilized in gelatin capsules) stimulated antibody production in more than 50% (5/8) cats which received the vaccine by the oral route.	1982	7128069
[attenuated rabies virus, era strain, in cattle and dogs vaccinated with multiple doses].	investigation on the vaccination of 18 cattle and 5 dogs against rabies is reported. each animal received multiple doses of era strain vaccine intramuscularly in the gluteal or masseter region. the saliva, the brain and salivary glands of the vaccinated animals were examined to detect the presence of era virus using immunofluorescent test and mouse inoculation. the virus was never found in the saliva and organs of treated animals. circulating antibodies against era rabies virus were detected in ...	1982	7128070
antibody levels following era rabies vaccine in cattle.	the humoral response in cattle treated with era strain rabies vaccine, was studied utilizing the following criteria: antibody titres determined by rffit, seroimmunological monitoring of experimentally vaccinated animals, a comparison of data obtained from cattle vaccinated and maintained under field conditions in the absence of anamnestic information. the average antibody responses in the field experiment are in agreement with the laboratory animal response, both showing highest levels at day 15 ...	1982	7128071
the structural proteins of rabies virus.	the five structural proteins of rabies virus, l, g, n, m1 and m2 have been re-evaluated in light of recent results. it has been found that the m1 protein is associated with the n protein which together with the l protein and the rna forms the nucleocapsid complex. only the g and m2 proteins could be visualized on the surface of infected cells. therefore, it is proposed that the m1 protein be renamed ns analogous to vesicular stomatitis virus and that the m2 protein, being the only membrane prote ...	1982	7128073
purification, concentration and evaluation of rabies virus antigen.	a number of concentration and purification procedures for rabies virus antigen have been developed during the last decades but only ultrafiltration and density gradient centrifugation have been found suitable for large scale production. the antibody binding test developed by arko, wiktor and sikes was modified and was found useful for evaluation of inactivated antigen-concentrates. this test was used as an 'in process' control. three examples of practical experience are reported and discussed.	1982	7128074
[modalities of production and immunity conferred by an inactivated rabies vaccine originating from cell culture].	further to guidelines advised by the world health organization, an inactivated rabies vaccine was prepared from virus propagated on cell culture. this vaccine is presented either in the freeze-dried form or in the liquid form together with an immunity adjuvant. the specific and nonspecific immunity of the vaccine is excellent. the potency, tested in laboratory animals and in species for which the vaccine is intended, satisfies recommendations published by the w.h.o. the immunity persistence, eva ...	1982	7128075
potency of two rabies vaccines in cats as determined by antibody assay and virulent virus challenge.	the persistence of immunity induced by a modified live virus rabies vaccine (sad strain) and an inactivated rabies vaccine combined with panleukopenia vaccine in cats was studied serologically and by virulent rabies virus challenge. the source of challenge virus was a suspension of a dog salivary gland. all 16 cats vaccinated with the inactivated vaccine developed high antibody titres and 15 were protected against the virus challenge. all 8 cats vaccinated with the mlv vaccine produced a serolog ...	1982	7128076
[radio-tracking of rabid foxes].	three wild foxes were trapped, inoculated with rabid fox salivary glands virus and radio-tracked straightaway for about three weeks until the death of the animal. comparison of movements between incubation and clinical period indicate principally no obvious alteration of the activity area; an important increase in movement, especially during the day-time and lastly some variable changes in the activity pattern according to the individual. a common characteristic was a long period of immobility, ...	1982	7128084
[influence of rabies virus culture duration on viral glycoprotein integrity].	regardless of the duration of the culture period, the amount of both glycoprotein g and sialic acid bound to the rabies virion as not modified. the major proteins of the viral suspension were the same proteins as those of the virion, except one glycoprotein (mw 70,000).	1982	7128091
[possible role of ticks as a reservoir of rabies virus].	in western europe the fox and other carnivora are parasitized by two specific ticks. the study of host-parasite relationships and knowledge of rabies epidemiology led us to investigate for a possible part played by ticks as reservoir of rabies virus. several hundreds of ticks (pholeoixodes hexagonus and pholeoixodes canisuga) were collected on wild foxes. ticks collected from naturally infected rabid foxes were set on healthy foxes in order to contaminate them. ticks collected from non-rabid fox ...	1982	7128092
[molecular and cellular aspects of the pathogenesis of rabies].	the true causes of the beginning of the symptoms and the eventual mortality of rabies are not very well known. immunopathological factors certainly intervene, but they only complete a process of neuronal alteration. contrary to other viruses which lyse the infected cells, the rabies virus does not necessarily destroy the neurones which are the preferential target cells. on the contrary, rna synthesis is stimulated during cns infection by the rabies virus. synthesis is not stimulated by the multi ...	1982	7128098
[progression of the rabies virus in the visual system of the rat].	the cvs rabies virus, inoculated in the anterior chamber of the eye, is transported from the retina to the central nervous system only along the accessory optic tract and invades transsynaptically its terminal nuclei. on the other hand the retino-geniculo-cortical system is affected much later. thus the virus shows a special affinity for a well defined neuronal system and behaves as a precise tracer of its intracerebral connections.	1982	7128099
rabies virus pathogenicity and challenge. influence of the method of preparation, the route of inoculation, and the species. comparison of the characteristics of the modified, fixed and wild strains.	the challenge we carried out, which regularly brought about the death of the control animals, led us to study the different factors influencing the pathogenicity of the rabies virus. so, the method of preparation is important. the strain nyc, prepared from the salivary glands is extremely pathogenic for dogs; however, when it is prepared from mouse brains after nine passages have been made, it proves to be already partially modified. one then notices a death-rate which is less severe, even when ...	1982	7128100
fatal encephalitis apparently due to rabies. occurrence after treatment with human diploid cell vaccine but not rabies immune globulin.		1982	7131683
a sensitive bioassay system for detecting defective interfering particles of rabies virus.		1982	7135836
[experimental transmission of rabies to the ferret by an ixodoidea: pholeoixodes rugicollis (schultze and schlottke, 1929)].		1982	7136476
haemadsorption test for rabies virus.		1982	7142683
[humoral immune response as a laboratory criterion for evaluation of the effectiveness of rabies vaccines].		1982	7144329
[effect of cyclophosphane on the experimental production of abortive and chronic forms of rabies].		1982	7147907
a clinical study of merieux human rabies immune globulin.		1982	7153223
geographic and seasonal distribution of rabies in skunks, foxes and bats in texas.	the geographic and seasonal distributions of the pathobiocenoses formed by rabies virus, the biotic provinces of texas, and skunks, foxes and bats were described using synoptic mapping and enumeration by calendar month. autocorrelation functions with 95% confidence intervals were calculated for the skunk pathobiocenose for lag periods up to 36 mo in length. the geographic distributions were fundamentally different, but all overlapped. the skunk and fox pathobiocenoses were associated with provin ...	1982	7154216
[biological variants of a population of strains of the rabies street virus].	experiments in mice weighing 6-7 g showed that a population of wild street rabies virus strains could contain from 1 to 3 biologic variants determining the clinical characteristics, duration of the incubation period and of the disease, and virus titres in the brain. fox strains l-1 and l-2 produced only paralytic rabies, the be strain isolated from a badger induced paralytic and chronic disease, and the population of the yak strain isolated from a boy bitten by a fox and timely given a complete ...	1982	7157781
intradermal use of human diploid cell vaccine for preexposure rabies immunizations.	in a study involving 240 faculty, students, and staff at the university of georgia college of veterinary medicine, 0.1 ml of a rabies human diploid cell vaccine administered intradermally on days 0, 7, and 28 induced adequate rabies antibody (greater than or equal to 0.5 iu/ml of serum) in all subjects by day 49. there were no significant differences in mean titers between groups of individuals with different rabies immunization histories by using a newly proposed index system for reporting such ...	1982	7161170
immunization of foxes vulpes vulpes by the oral and intramuscular routes with inactivated rabies vaccines.	inactivated rabies vaccines prepared from common vaccine strains of virus were inoculated into foxes by the intramuscular and intestinal route. there were differences among the vaccines in the duration of antibody produced after intramuscular administration. inactivated vaccines deposited directly into the lumen of the duodenum by means of a fiberscope caused seroconversion in some foxes, especially following a booster dose, but the antibodies produced were for the most part of short duration. t ...	1982	7172102
[oral immunization of foxes against rabies: stabilization and use of bait for virus application].		1982	7180249
[antigenic variants of the rabies virus. selection with antiglycoprotein monoclonal antibodies].		1982	7181560
[preventive antirabies vaccination. evaluation of humoral immunity].		1982	7181561
[comparative study of 2 postexposure antirabies vaccines].		1982	7181562
[the reservoir of rabies virus in tunisia].		1982	7181568
[antigenic spectrum of wild strains and vaccinal strains of rabies virus in senegal defined by antinucleocapsid monoclonal antibodies].		1982	7181573
studies of the presence of rabies virus among stray dogs in dhaka city.	one hundred and thirty one stray dogs were captured from dhaka city. anti-mortem as well post-mortem examination of the dogs for rabies were conducted. microscopic studies and biological tests were carried-out with dog's brain for the detection of rabies virus. one dog was found to have rabies virus in its brain. the stray dogs under dhaka municipal corporation area therefore, seem to harbour rabies virus in their brains and could be a source of potential danger to the community after the full d ...	1982	7184499
[determination of the protective value of anti-rabies vaccines for human use in international units in the nih-test].		1982	7185030
non-bite transmission of rabies in kudu (tragelaphus strepsiceros).	the titres of rabies virus in the saliva of kudu are higher than those of the salivary glands. the high titres are an indication of active excretion and multiplication in tissues other than the salivary glands. two out of 4 kudu died of rabies after experimental infection by the instillation of infected saliva onto their buccal and nasal mucosae. mice and 2 cattle resisted a similar exposure. kudu also developed antibodies against rabies after instillation of hep flury virus onto their nasal and ...	1982	7185035
[development and persistence of the humoral immune response induced by the preventive treatment with rabies vaccine (hdcs) in a group of laboratory workers].		1982	7187849
[immune rabies status of 200 vaccinated dogs from the canton of zurich].		1982	7201161
identification of rabies antigen in human and animal tissues.		1983	6372590
the acetylcholine receptor as a cellular receptor for rabies virus.	characterization of specific host cell receptors for enveloped viruses is a difficult problem because many enveloped viruses bind to a variety of substrates which are not obviously related to tissue tropisms in the intact host. viruses with a limited cellular tropism in infected animals present useful models for studying the mechanisms by which virus attachment regulates the disease process. rabies virus is a rhabdovirus which exhibits a marked neuronotropism in infected animals. limited data su ...	1983	6367238
[use of monoclonal antibodies in virology].		1983	6322450
genetic control of resistance to street rabies virus in mice.	resistance to intraperitoneally inoculated street rabies virus (srv) in mice was shown to be under genetic control. sjl/j, cba/j, dba/2j, and balb/can mice were resistant, whereas a/wysn/j and a.sw/snj mice were susceptible. in addition, female mice of the resistant balb/can and dba/2j strains were more resistant than their male counterparts. resistance was not controlled solely by the major histocompatibility locus because susceptible a.sw/snj and resistant sjl/j mice have the same h-2s haploty ...	1983	6822785
chemical and immunological analysis of the rabies soluble glycoprotein.	soluble glycoprotein (gs), purified from virion-depleted, rabies-infected tissue culture fluid, was chemically and immunologically analyzed. a comparison of this antigen with the virion-associated glycoprotein showed that gs lacks 58 amino acid residues from the carboxy terminus of the virion-associated glycoprotein. analysis with monoclonal antibodies revealed that all the epitopes of the viral glycoprotein are also present in the soluble glycoprotein. however, when tested for its ability to pr ...	1983	6823748
molecular basis of rabies virus virulence. ii. identification of a site on the cvs glycoprotein associated with virulence.	nine anti-g monoclonal antibodies were used to select mutants of the cvs strain of rabies virus resistant to neutralization. seven mutants were avirulent in adult mice and two others exhibited an attenuated pathogenicity. both categories were resistant to monoclonal antibodies 194-2 and 248-8. virulence appears to be associated with a particular configuration of a region of the glycoprotein which is located at the intersection of the epitopes recognized by these two monoclonal antibodies. our re ...	1983	6827249
studies on pathogenic, immunogenic, and protective efficiency of fox rabies virus before and after adaptation to cell culture: application to vaccination against rabies.	rabies virus from the submandibular salivary gland of a naturally infected fox was adapted to growth in bhk-21 cells. the pathogenicity of the original isolate and the cell culture adapted virus were compared by the intramuscular and oral routes in mice and foxes. animals surviving exposure were tested for serum rabies antibodies (immunogenic efficiency) and for their ability to survive a second challenge with rabies virus (protective efficiency). in mice, ratios between lethal and protective do ...	1983	6831313
the primary hamster kidney cell rabies vaccine: adaptation of viral strain, production of vaccine, and pre- and postexposure treatment.	the hamster kidney cell rabies vaccine was investigated as a substitute for classical nervous tissue rabies vaccine. the beijing strain of fixed rabies virus was adapted to primary hamster kidney cells (phkcs), and four types of rabies vaccine (plain, adjuvant, concentrated, and concentrated adjuvant vaccines) were developed for human use. the potencies of the vaccines met the requirements of the world health organization, and these vaccines elicited rather satisfactory antibody responses in vol ...	1983	6833794
antigenic sites on the cvs rabies virus glycoprotein: analysis with monoclonal antibodies.	antigenic variation in the glycoprotein of rabies (cvs-11) virus was studied. neutralization-resistant variant viruses were isolated in vitro at high frequency (10(-4) to 10(-5)) in the presence of anti-glycoprotein monoclonal antibody. analysis of these variants identified at least three functionally independent antigenic sites, based on the grouping of variants that were no longer neutralized by one or more of a panel of 24 monoclonal antibodies. competition radioimmunoassay suggested that one ...	1983	6834008
rapid test for detection of rabies antibodies in human serum.	a simple, sensitive, rapid method based on the principle of immunoadherence hemagglutination (iaha) has been devised for the detection of rabies antibody. in this test, fixation of complement to complexes of rabies antigen with specific antibodies is readily detected by agglutination of human erythrocytes bearing receptors for c3. sera from individuals undergoing preexposure rabies immunization were tested for rabies antibodies by the iaha method and by a virus neutralization test performed in t ...	1983	6841582
[effect of the interferon inducer rff2 on the course of an infection due to the rabies virus in mice].	the data of the study on the influence of an interferon inducer, phage rff2 rna, on the course of infection with fixed rabies virus and on the formation of postvaccination immunity are presented. the inoculation of the inducer in a dose of 1 mg/kg was shown to produce interferon in the blood of white mice within 6 hours up to 320 units/ml which decreased by 24 hours to 20-40 units/ml. no protective effect, however, was observed upon intracerebral inoculation of white mice with fixed rabies virus ...	1983	6845719
prevalence of abortive canine rabies in chiang mai, thailand.		1983	6854177
neurotropism of rabies virus. an in vitro study.	the relative susceptibility of neurons and glia, grown as monolayers in vitro, to rabies virus infection was explored. established cell lines of neuronal or glial phenotype and primary cultures of cells derived from mouse dorsal root ganglia (drc) or brain were used as homologues of the targets of rabies virus in the nervous system. fixed rabies virus (cvs) strain was used in most experiments; other fixed rabies strains (pv, hep, era) and a street rabies virus isolate were used in some. virus-ce ...	1983	6864237
a study of antibody levels in wild ruminants vaccinated against rabies.	the authors have vaccinated 22 fallow deer (dama dama) and 10 mouflons (ovis ammon musimon) against rabies with an inactivated vaccine: 4 fallow deer with 1 ml, 14 fallow deer and 10 mouflons with 2 ml, 4 animals were kept as controls (fallow deer). the antibody responses were checked by fluorescent foci inhibition carried out on blood samples collected during a two-year period. all the animals developed antibody titres and were still protected after 24 months.	1983	6868344
comparison of primary skunk brain and kidney and raccoon kidney cells with established cell lines for isolation and propagation of street rabies virus.	cell cultures prepared from skunk kidney, raccoon kidney, and skunk brain were compared with cer, murine neuroblastoma (c1300, clone na), baby hamster kidney (bhk-21, s-13), and dog kidney (mdck) cell lines for virus isolation and propagation of street and fixed rabies virus. the skunk brain cells were suitable for efficient replication of all the virus isolates. they were comparable to cer and murine neuroblastoma cells for virus isolation and propagation. none of the other cell cultures was sa ...	1983	6885165
activity of human serum lipoproteins on the infectivity of rhabdoviruses.	the inhibiting activity of various human serum lipoprotein classes and their lipid components on the infectivity of rhabdoviruses has been studied. the research has been carried out according to different experimental procedures on both the vesicular stomatitis virus (indiana strain), and the fixed rabies virus (cvs strain). the results obtained have shown an inhibition of the infectivity of vsv and cvs, mainly linked to the very low and low density lipoprotein classes. it has also been demonstr ...	1983	6306404
[rabies vaccine in czechoslovakia. ii. lyophilized rabies vaccine from brain tissue inactivated by uv irradiation].		1983	6218902
immunoelectron microscopic localization of rabies virus antigen in central nervous system and peripheral tissue using low-temperature embedding and protein a-gold.	a protein a-gold technique was used in conjunction with low temperature embedding to visualize ultrastructurally mature virions and sites of viral replication in the brains of rabies virus-infected mice after peripheral inoculation of virus. the association of viral profiles and gold particles with synaptic membranes, microtubules and rough endoplasmic reticulum suggested a mechanism of rabies virus transport within the central nervous system. early interactions of inflammatory cells with the vi ...	1983	6203925
[modification of the incubation period of the fixed babeş strain in relation to the nature of the host cells. the effects on viral titer and on the immunogenic value of rabies vaccines].		1983	6336510
rhesus diploid rabies vaccine (adsorbed), a new rabies vaccine. ii. results of clinical studies simulating prophylactic therapy for rabies exposure.	rhesus diploid-cell-strain rabies vaccine (rdrv) (adsorbed) is a new rabies vaccine intended for use in man. sixty volunteers were given five doses of rdrv at 0, 3, 7, 14, and 28 days to simulate prophylactic treatment of persons exposed to a rabid animal. thirty-five volunteers were given commercial high-titer rabies immune globulin, 20 iu/kg, before the first dose of rdrv, and 25 were given rdrv without prior rabies immune globulin. antibody responses at 14, 28, and 42 days were comparable wit ...	1983	6341639
epidemiologic analysis of antigenic variations of street rabies virus: detection by monoclonal antibodies.	the nucleocapsid antigen of 204 strains of street rabies virus, which originated in europe, africa and asia, was analyzed by fluorescent antibody staining technique with a panel of 20 monoclonal antibodies specific for nucleocapsid of rabies and rabies-related viruses. a definite pattern of reactivity was observed with strains of the same geographic origin with the exception of strains originating from madagascar, thailand and iran which were more diversified. mice immunized with a vaccine prepa ...	1983	6342369
[identification of silvatic and arctic rabies strains using monoclonal antibodies].		1983	6346689
an in vivo and in vitro study of rabies virus infection of the rat superior cervical ganglia.	in the attempt to develop a homogeneous neuronal model to study rabies pathogenesis in vivo and in vitro, the superior cervical ganglia (scg) were chosen because of their unique features. in vivo infection of the scg was attempted by inoculation of fixed rabies virus into the anterior eye chamber. however, viral by this route as well as intracerebrally failed to infect this neuronal organ in adult rats whereas the infection was poorly efficient in 24 hours newborn rats. dissociated cell cultures ...	1983	6347127
rabies subunit vaccines.		1983	6348210
immunofluorescent examination of the skin of rabies-infected animals as a means of early detection of rabies virus antigen.	correlations were made on immunofluorescence positivity to antirabies conjugate between cranium-derived nerve fibers in skin and traditional samplings of brain tissue from several species and illness categories of animals with naturally acquired rabies. the overall correlation of results from all categories was about 98% (n, 104) for those that were brain positive and 100% (n, 99) for those that were brain negative. some animals that ultimately developed rabies were found to have immunofluoresce ...	1983	6355152
experimental rabies in skunks: mechanisms of infection of the salivary glands.	striped skunks (mephitis mephitis) were inoculated into the right submandibular salivary gland with street rabies virus. they were killed at various times after inoculation and several tissues were examined by immunofluorescence and light microscopy. right and left superior cervical, nodose and trigeminal ganglia, medulla oblongata and at least three regions of right and left submandibular salivary glands were examined by the fluorescent antibody technique. intracerebral titrations of salivary g ...	1983	6357414
[comparison of 4 technics for serologic titration of antibodies against rabies virus in dogs].	four different serological techniques were used for the determination of antibody levels against rabies virus in 55 vaccinated street dogs: mouse neutralization test (reference), rapid fluorescent focus inhibition test, plaque reduction test and immunoenzymatic test (protein a). the results obtained with each of the last three methods were compared with those obtained with the reference test: correlation coefficients were, respectively, 0.810, 0.812 and 0.682, each being significantly correlated ...	1983	6358227
rabies virus glycoprotein analogs: biosynthesis in escherichia coli.	the surface of rabies virus is composed of an approximately 60,000 dalton glycoprotein, in which most of the antigenic and immunogenic determinants of the virus reside. we have constructed plasmids for the direct expression in escherichia coli of the mature full length rabies glycoprotein gene and also for the expression of a glycoprotein gene which has been truncated to exclude the coding region for a hydrophobic, possibly transmembrane, domain of the protein. escherichia coli harboring the pla ...	1983	6297004
nucleotide sequence of a cdna clone encoding the entire glycoprotein from the new jersey serotype of vesicular stomatitis virus.	the nucleotide sequence of the mrna encoding the glycoprotein from the new jersey serotype of vesicular stomatitis virus (vsv) was determined from a cdna clone containing the entire coding region. the sequence of 12 5'-terminal noncoding nucleotides present in the mrna but not in the cdna clone was determined from a primer extended to the 5' terminus of the mrna. the mrna is 1,573 nucleotides long (excluding polyadenylic acid) and encodes a protein of 517 amino acids. only six nucleotides occur ...	1983	6298453
inhibition of rous sarcoma virus-induced transformation by preinfection with rhabdoviruses.	in vivo preinfection of chicks with rabies virus (rv) or vesicular stomatitis virus (vsv) ts 1026 inhibits tumour formation after superinfection with rous sarcoma virus (rsv). the degree of inhibition depends on the titre of the infecting viruses and the interval between rhabdovirus and rsv infection. in vitro, cells preinfected with vsv ts 1026 under non-permissive conditions and superinfected with rsv, are not transformed as judged by cell morphology, serum requirement for growth or the capaci ...	1983	6300284
[the effect of adjuvant substances on the antigenic activity of cellular antirabies vaccine in experiments on cattle].	trials were conducted with young cattle to study the effect of adjuvants, applied subcutaneously and intramuscularly, upon the antigenic activity of live and inactivated cell rabies vaccine prepared from the vnukovo -32 strain at the level of the 107th series cell passage. cerebral vaccine of fermi type was also used in the trials for comparison. the antibodies were parallelly titrated by four methods, three of which were conducted in vitro. the levels of antirabies antibodies indicate a possibi ...	1983	6426120
rabies in humans.		1983	6554155
anti-idiotypic antibodies induce neutralizing antibodies to rabies virus glycoprotein.	rabbit anti-idiotypic antibodies (alpha id ab) were prepared against five murine monoclonal antibodies (mab) specific for the rabies virus glycoprotein. four of the mab were directed against three known, type-specific, neutralizing sites on the glycoprotein, and the other mab was directed against a topographically uncharacterized, nonneutralizing epitope. an absence of significant cross-reactivity among the alpha id ab for heterologous mab suggested that the alpha id ab were highly specific for ...	1983	6605428
persistence of rabies antibody in free-ranging raccoons.	the immune status of a wildlife population to rabies virus probably influences the occurrences of epizootics among that species in a given geographical area. this is not to say that enzootic transmission of the virus will not occur, but rather that attainment of epizootic levels may be hampered through herd immunity. after an epizootic of rabies in a raccoon population in the fall of 1970, a serologic surveillance program was initiated from november 1970 through august 1974. the surveillance pro ...	1983	6619583
mokola virus infection in cats and a dog in zimbabwe.		1983	6623871
[specific and nonspecific humoral response to vaccination with the anti-rabies vaccination agents rabivac and vnukovo-32].		1983	6627311
rabies in oklahoma: report of a human case.		1983	6631574
preliminary study on fixed rabies virus strain "roma". i: adaptation on bhk21/s13 cells.	in this study the attempts to adapt roma fixed rabies virus to bhk21/s13 cells and human diploid fibroblasts, for a better characterization of the virus, are reported. bhk21 cells were infected with the virus and maintained in culture for more than 100 passages. a persistently infected culture by rabies virus was obtained. attempts to propagate virus in human diploid fibroblasts were unsuccessful.	1983	6633274
[aspects of the immunogenic capacities of the fixed babeş rabies virus to vaccines prepared from nerve tissue of different categories of experimental animals].		1983	6635460
[antigenic activity and the reactogenicity of a concentrated, purified, uv-inactivated cultured rabies vaccine].	the results of the study of concentrated, purified, uv-inactivated cell-culture rabies vaccine, obtained from strain vnukovo-22, passage 33-40, in the primary culture of syrian hamster kidney cells, demonstrated the pronounced antigenic potency of this vaccine: when introduced intramuscularly in 3-4 injections at certain intervals, it induced the production of virus-neutralizing antibodies in high titers. in tests on volunteers the vaccine proved to be nonreactogenic.	1983	6637275
a study of candidate rabies vaccines for a national reference preparation for the evaluation of antigenic potency.	an unconcentrated and a concentrated lot of rabies vaccine prepared in syrian hamster kidney cell culture from the vnukovo-32 strain have been examined for their suitability as national reference preparations for rabies vaccine. the antigenic potencies of the preparations were assessed by the nih test using both fixed and street strains of rabies virus and by the method of antibody induction. the candidate vaccines were calibrated in comparative assays with the who 3rd international reference pr ...	1983	6643509
rabies virus in the tonsils of a carrier dog.	a female dog, inoculated with a rabies isolate from the saliva of an apparently healthy ethiopian dog, developed rabies but later recovered without supportive treatment. rabies virus was isolated from the saliva collected 42, 169 and 305 days after recovery. sixteen months after it recovered, the dog suddenly died after giving birth to two stillborn puppies. at necropsy, viral antigen could be detected in the tonsils and the brain tissue, but viable virus was isolated from the palatine tonsils o ...	1983	6651535
antibody response to a single intradermal booster dose of rabies human diploid cell vaccine.		1983	6654729
a continuous cell line, gk, derived from the kidney tissue of mongolian gerbil (meriones unguiculatus) and its virological application.	a fibroblast-like continuous cell line was established from the kidney tissue of the female mongolian gerbil (meriones unguiculatus) and designated as gk cell line. the cells were susceptible to the infection with several dna and rna animal viruses, particularly with four prototype strains of dengue viruses and the hep-flury strain of rabies virus.	1983	6656002
[therapeutic activity of the combined use of an interferon inducer and vaccine in experimental rabies].	experiments in mice inoculated intramuscularly with a large dose of virulent street rabies virus demonstrated effectiveness of combined treatment with an interferon inducer (double-strand rna) and vaccine. the treatment was started 24 hours after inoculation. the degree of protection of the animals treated by the combined method depended on the site of ds-rna inoculation: intracerebral inoculation produced 58% protection (p less than 0.001), intravenous 35% (p less than 0,01), and intramuscular ...	1983	6659475
rabies neutralizing antibodies determination by the modified counterimmunoelectrophoresis test and the rapid fluorescent focus inhibition test.	the correlation between the modified counterimmunoelectrophoresis and the rapid fluorescent focus inhibition tests for detecting rabies virus antibodies in human sera was studied, using as reference the standard mouse neutralization test. statistical analyses showed good correlation among the three serological tests. there were no statistically significant differences in titers obtained by serum neutralization and rapid fluorescent focus inhibition tests and the estimated titers based on the res ...	1983	6659741
[preventive rabies immunization--is simplification in view?].		1983	6669819
study of the presence of rabies virus in indigenous bats.	one hundred and thirteen fruit eating and insectivorous bats were captured from different parts of bangladesh. antemortem and post mortem examinations of the bats for rabies were conducted. microscopic studies and biological tests were carried-out with bat's brain for the detection of rabies virus. the results were negative. it may therefore, be concluded that the insectivorous and fruit eating bats from different parts of bangladesh do not act as the reservoir for rabies virus.	1983	6675666
the use of various immunochemical, biochemical and biological methods for the analysis of rabies virus production in tissue cultures.	for the preparation of rabies vaccines, virus was grown in cultures of primary cells (bovine fetal kidney) or heteroploid cell lines (hak and vero). comparative analysis of concentrated and/or purified antigen has shown a good correlation between the protective capacity (as determined by the nih test for potency) on one hand, and hemagglutinating titer, optical absorbance at 280 nm and glycoprotein content (evaluated by the enzyme-immuno assay - eia) on the other. furthermore, the evaluation of ...	1983	6677532
protective antibodies after vaccination with human diploid cell rabies vaccine.		1983	6681004
[prophylactic and therapeutic activity of an interferon inducer in mice infected intracerebrally with rabies street virus].	experiments in mice inoculated intracerebrally with street rabies virus demonstrated a protective effect of an interferon inducer (double-stranded rna of phage f2). a high degree of protection was observed after intracerebral inoculation of the inducer both 24 h before and 4 h after virus infection, with a considerable increase of the average life-span of the animals. intramuscular and intraperitoneal inoculation of the inducer proved ineffective.	1983	6189300
[effectiveness of dsrna as an interferon inducer in the intramuscular infection of mice with rabies street virus].	a protective effect of double-stranded rna as interferon inducer was demonstrated in mice inoculated intramuscularly with street rabies virus. a significant degree of protection was observed when the inducer was inoculated intracerebrally and at the site of virus inoculation both 24 h before and 4 and 24 h after infection. inoculation of the inducer into the muscle opposite to the infected leg and subcutaneously into the back proved to be ineffective. it was established that rabies infection cou ...	1983	6191440
induction of antigen-specific antibody response in human peripheral blood lymphocytes in vitro by a dog kidney cell vaccine against rabies virus (dkcv).	in the present report an in vitro method for obtaining a secondary human antibody response to a dog kidney cell vaccine against rabies virus (dkcv) is described. cultures of peripheral blood mononuclear cells from normal rabies-immune and nonimmune donors were stimulated in vitro by dkcv. the production of virus-specific antibody in supernatant fluids was monitored by elisa. antibody was produced by lymphocytes from rabies-immune individuals, whereas those of nonimmune subjects consistently fail ...	1983	6193180
[intra-axonal circulation in peripheral nerves and its importance].		1983	6195741
intracytoplasmic neuronal inclusions in the hippocampus of non-rabid moose, alces alces (l.).		1983	6196493
altered expression of rabies virus antigenic determinants associated with chronic infection and virulence.		1983	6185633
characterization of an antigenic determinant of the glycoprotein that correlates with pathogenicity of rabies virus.	the pathogenicity of fixed rabies virus strains for adult mice depends on the presence of an antigenic determinant on the viral glycoprotein. two virus-neutralizing monoclonal antibodies have been used to identify this determinant. all pathogenic strains of fixed rabies virus bind to these antibodies and are neutralized by them, whereas nonpathogenic strains fail to react with these monoclonal antibodies and are not neutralized by them. antigenic variants of the rabies virus with altered glycopr ...	1983	6185960
stability of human diploid-cell-strain rabies vaccine at high ambient temperatures.	a batch of lyophilised human diploid-cell-strain rabies vaccine was divided into three batches, which were exposed to different temperatures during their distribution to and storage at three centres in pakistan. vaccine potency after exposure to these temperatures was tested by measuring antibody response in those given the vaccine, and by three different laboratory tests. the results indicate that the vaccine retains its antigenicity for man and for laboratory tests despite continuous exposure ...	1983	6132229
rabies.		1983	6132275