Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| epstein-barr virus-specific rna. ii. analysis of polyadenylated viral rna in restringent, abortive, and prooductive infections. | the complexity and abundance of epstein-barr (ebv)-specific rna in cell cultures restringently, abortively, and productively infected with ebv has been analyed by hybridization of the infected cell rna with purified viral dna. the data indicate the following. (i) cultures containing productively infected cells contain viral rna encoded by at least 45% of ebv dna, and almost all of the species of viral rna are present in the polyadenylated and polyribosomal rna fractions. (ii) restringently infec ... | 1977 | 194056 |
| circular epstein-barr virus genomes of reduced size in a human lymphoid cell line of infectious mononucleosis origin. | circular epstein-barr virus (ebv) dna molecules have been purified and characterized from a human lymphoid cell line derived from a case of heterophile antibody-positive, blood transfusion-induced infectious mononucleosis, 883l. the circular ebv dna in three cell lines obtained by transformation of human umbilical cord blood leukocytes with a strain of ebv originally derived from 883l was also studied. as estimated from sedimentation velocity data and electron microscopy, the circular ebv dna mo ... | 1977 | 194059 |
| elevated epstein-barr antibodies in an infant with hepatitis. | 1977 | 194143 | |
| immune surveillance against virus-induced tumors and nonrejectability of spontaneous tumors: contrasting consequences of host versus tumor evolution. | spontaneous tumours are defined as tumors that develop in the absence of all experimental interference. in contrast to the widely documented, strong rejection reactions against most virus-induced tumors, spontaneous tumors evoke little or no detectable rejection reaction in intact or preimmunized syngeneic hosts. the difference can be viewed in relation to the contrasting natural history of the two conditions. spontaneous tumors evolve in several steps, as a fule. "tumor progression" is a microe ... | 1977 | 194247 |
| rejectability of virus-induced tumors and nonrejectability of spontaneous tumors: a lesson in contrasts. | in contrast to the excellent surveillance against tumors induced by the ubiquitous viruses in their natural host species, spontaneous tumors developing naturally, without experimental interference, evoke little or no rejection reaction. this may be viewed in relation to the natural history of tumors. in most cases, tumors evolve in several steps, with a successful of clonal variants following each other, characterized by increasing independence of host regulations (including immune restrictions) ... | 1977 | 194366 |
| viral infections in kidney donors and recipients: a prospective study. | 1977 | 194367 | |
| iga antibodies to epstein-barr viral capsid antigens in saliva of nasopharyngeal carcinoma patients. | 1977 | 194619 | |
| cold agglutinins in infectious mononucleosis and heterophil-antibody-negative mononucleosis-like syndromes. | cold agglutinins (ca) were evaluated prospectively in patients with various mononucleosis syndromes and in a large control group. cold agglutinins with anti-i specificity were seen mainly in heterophil-positive or -negative epstein-barr virus (ebv)-induced infectious mononucleosis (31.8% of cases). unclassified ca with equal reactivity against cord and adult erythrocytes were seen in 56 of 150 (37.3%) cases of heterophil-antibody-positive infectious mononucleosis (im), in 1 of 7 (14.3%) cases of ... | 1977 | 194643 |
| relationships between complement activation, complement binding, and ebv absorption by human hematopoietic cell lines. | 1977 | 194711 | |
| [herpesvirus antibodies in hodgkin's disease and some lympho-hematopoietic diseases in children and adolescents]. | 1977 | 194715 | |
| comparative immunology of carcinogenesis by dna viruses. | 1977 | 194745 | |
| clinical implications of immunity to oncogenic viruses. | 1977 | 194750 | |
| an effect human leukaemic cell line: reh. | 1977 | 194778 | |
| differential induction of epstein-barr virus-related antigens in heterokaryon cultures. | different paterns of induction of epstein-barr virus (ebv)-related antigens were observed in heterokaryons produced by sendai virus-mediated fusion of producer and non-producer human lymphoblastoid cells with various other cell types. ebv-related early antigens (ea) and viral capsid antigen (vca) could obviously be induced in heterokaryons between producer cells (p3hr-1 and qimr-wil), normally expressing these natigens at very low frequency, and human fl or hela cells. positive cells were detect ... | 1977 | 194844 |
| comparative studies on adult donor lymphocytes infected by eb virus in vivo or in vitro: origin of transformed cells arising in co-cultures with foetal lymphocytes. | co-cultures were set up between equal numbers of mononuclear cells from the blood of eb virus-infected individuals, either acute im patients or healthy seropositive adult donors, and foetal cord blood mononuclear cells of the opposite sex. the cell lines arising in the co-cultures were of mixed origin, with foetal cells predominating in many cases. in contrast, when mononuclear cells from seronegative adult donors were first infected with eb virus in vitro and then 5 to 12 days later co-cultured ... | 1977 | 194845 |
| detection localization of epstein-barr virus-associated early antigens in single cells by autoradiography using 125i-labeled antibodies. (with 1 color plate). | a characteristic feature of virus-transformed cells is the expression of virus-specific antigens usually detectable by immunological or radioimmune procedures. we report here an autoradiographic method for the detection and localization of such antigens in individual cells which combines the cellular specificity and radiolabeling sensitivity of the above procedures. as a test system we have studied the reaction between virus antigen in some epstein-barr virus (ebv) dna-containing cell lines and ... | 1977 | 194866 |
| transforming activity and antigenicity of an epstein-barr-like virus from lymphoblastoid cell lines of baboons with lymphoid disease. | two lymphoblastoid cell lines were established from baboons with lymphoid disease. cells of these lines were positive for complement and fc receptors but lacked sheep cell receptors, theraby indicating b-cell origin. the cells contained antigens which cross-reacted with epstein-barr virus (ebv), viral capsid antigen (vca), early antigen (ea) and membrane antigen (ma). both lines released virus with in vitro transforming activity for lymphocytes of several primate species including humans. cells ... | 1977 | 194867 |
| immune deficiency of t system with possible t cell regulatory activity defect. | the occurrence of t system immunodeficiency in an infant together with excessive production of igm and, to a lesser degree, of igg and iga, is an unusual combination. a case is reported in which an unremitting lung infection with lymphadenopathy and hepatosplenomegaly developed in a previously healthy two-month-old infant. leukocytosis with lymphocytosis, monocytosis and eosinophilia was rapidly followed by leukopenia and lymphocytepenia after a blood transfusion for anemia. there was a transien ... | 1977 | 194869 |
| suppression of in vitro epstein-barr virus infection. a new role for adult human t lymphocytes. | studies have been performed on in vitro infection by epstein-barr virus (ebv) of subpopulations of human lymphocytes. b cells of adult peripheral or fetal cord blood transform with equal efficiency, whether assayed by dna synthesis induction or by outgrowth of transformed lymphocytes. in contrast, unfractionated adult lymphocytes transform much less efficiently than those from fetal cord. reconstitution experiments of different cell preparations indicated that this difference was due to a suppre ... | 1977 | 195004 |
| antibodies to epstein-barr virus in nasopharyngeal carcinoma and other neoplastic conditions. | sera from patients with nasopharyngeal carcinoma (npc) or other malignant diseases and from apparently healthy controls were examined for epstein-barr virus (ebv) antibodies. a difference existed in the percentage of positive sera among the groups studied. high-titer antibody levels were observed in the npc group, but no statistical difference was found among other groups of patients and controls. the data reaffirmed the association of ebv with npc but did not support its etiologic role in the d ... | 1977 | 195074 |
| establishment of an epstein-barr virus-determined nuclear antigen-negative human b-cell line from acute lymphoblastic leukemia. | a human b-cell line designated as ball-1 was established from the peripheral blood of a patient with acute lymphoblastic leukemia (all). neither epstein-barr virus (ebv) particles nor ebv-determined nuclear antigen (ebna) was detectable. the morphologic and growth characteristics were clearly distinct from those of numerous ebv-positive lymphoblastoid cell lines previously reported. ball-1 cells probably originated from the donor's leukemia cells as judged from their cytogenetic, morphologic, an ... | 1977 | 195075 |
| presence of epstein-barr virus receptors, but absence of virus penetration, in cells of an epstein-barr virus genome-negative human lymphoblastoid t line (molt 4). | this paper reports a unique type of interaction of epstein-barr virus (ebv) with an ebv receptor-positive, genome-negative human lymphoid t cell line (molt 4), which can be summarized as follows. although molt 4 cells express receptors for ebv, they appear to block the penetration of this virus. these observations are derived from combined studies with immunofluorescence and electron microscopy. it is possible that t cell lines bearing receptors for ebv may express such a control on virus penetr ... | 1977 | 195091 |
| marked enhancement of interferon production in 5-bromodeoxyuridine treated human lymphoblastoid cells. | 1977 | 195215 | |
| evidence for an etiologic relation of the epstein-barr virus to human malignancies. | studies on virus-induced animal tumors have provided indirect approaches to a search for viruses causing human malignancies. epstein-barr virus (ebv), the cause of infectious mononucleosis, served to illustrate the usefulness of these approaches in linking ebv with burkitt's lymphoma and nasopharyngeal carcinoma. despite its demonstrated intimate association with these tumors the role of ebv in their causation remains uncertain. while a passenger role seems excluded, it cannot be decided whether ... | 1977 | 190497 |
| primary epstein-barr virus infections in children. | during a serioepidemiologic survey of a community, 13 (6.2%) of 209 children were found to be experiencing a current or recent primary epstein-barr virus (ebv) infection. the sera contained elevated antibody titers to viral capsid antigen of ebv, antibodies to early antigen (ea) of ebv, and specific igm. the frequency of primary infections was highest in the first decade of life. the primary ebv infections were usually asymptomatic. the antibody to ea was directed predominantly to the r componen ... | 1977 | 190581 |
| expression of red cell bga antigen in children. lack of correlation with previous eb virus infection. | the red cell bga antigen and the presence of eb virus antibody were determined in a group of children of mixed ages. evidence of previous infection with eb virus does not correlate with the degree of expression of the bga antigen on red cells. | 1977 | 190797 |
| cytomegalovirus mononucleosis in a healthy adult: association with hepatitis, secondary epstein-barr virus antibody response and immunosuppression. | a 35 year old previously healthy physician had clinical manifestations of a mononucleosis illness complicated by arthralgia, vesicular pharyngitis and hepatitis. initially, the patient had cytomegalovirus (cmv) viremia (predominantly in polymorphonuclear leukocytes) followed by the presence of cmv in the urine, throat and semen. he also had an antibody response to the epstein-barr virus which appeared to be a secondary type. during the acute phase of illness, only 7 per cent of the patient's lym ... | 1977 | 190884 |
| genital ulceration and infectious mononucleosis: report of a case. | 1977 | 190889 | |
| epstein-barr virus and human malignancy. | the association of the epstein-barr virus and two human malignancies, burkitt's lumphoma and nasopharyngeal carcinoma, is reviewed. seroepidemiologic, virologic, and immunologic evidence is summarized, and several hypotheses regarding a possible etiologic role for the epstein-barr virus in these tumors are presented. with our current state of knowledge we cannot conclude that the ipstein-barr virus is oncogenic in man, nor can we yet ascertain the biological and clinical significance of its asso ... | 1977 | 190930 |
| meningoencephalopathy secondary to infectious mononucleosis. unusual presentation with stupor and chorea. | we report a case of infectious mononucleosis in which central nervous system involvement was the presenting and sole manifestation of the disorder. the major symptomatology consisted of stupor, chorea, and signs of aseptic meningitis. we also discuss the clinical and laboratory features of the neurological manifestations of infectious mononucleosis and the theories as to its pathogenesis. | 1977 | 190986 |
| establishment of peripheral lymphoid cell cultures from patients with hodgkin's disease depending on epstein-barr-virus-reactivity and cellular immunity. | peripheral blood lymphocytes from 43 patients with hodgkin's disease were studied for spontaneous growth in longterm cultures in vitro. the rate of culture establishment in hodgkin's patients was dependant on a positive epstein-barr-virus (ebv)-seroreactivity and intact delayed hypersensitivity reaction to tuberculin. localized and inactive disease, as well as the absence of atypical mononuclear cells in the peripheral blood had a favourable influence on the longterm in vitro growth. the overall ... | 1977 | 191123 |
| infectious mononucleosis and fibrosing alveolitis. | 1977 | 191141 | |
| [burkitt's lymphoma]. | the burkitt's tumor is a neoplastic disease which occurs mostly in the tropics. sporadic cases however are distributed all over the world. this undifferentiated lymphosarcoma predominates in children. extralymphnodal in origin, quick growth and lack of pain are very characteristic signs. unattended most of the patients die within a few months. cytostatic treatment in connection with x-ray therapy and surgical proceedings show some results. the epstein-barr-virus is incriminated to play a causati ... | 1977 | 191341 |
| efficiency of transformation of lymphocytes by epstein-barr virus. | 1977 | 189490 | |
| [igm diagnosis of epstein-barr virus (ebv) infections by means of the immunofluorescent method]. | sera were investigated of patients possibly suffering from an ebv infection, without showing clinical features characteristic of infectious mononucleosis. the method of investigation was the detection of antibodies of the igm-type by means of the immunofluorescent method using a three-layer technique. diagnosis of ebv infection was established in 10 out of 90 patients with facial palsy, one with myelitis, one with sudden deafness and one with polyneuritis. in addition, 4 out of 19 cases of hepat ... | 1977 | 189514 |
| prognosis of nasopharyngeal carcinoma by epstein-barr virus antibody titer. | a total of 433 samples of serum were collected from 305 patients with histopathologically proved anaplastic nasopharyngeal carcinoma (npc). antibodies against viral capsid antigens (vca) of epstein-barr (eb) virus were titrated by means of indirect fluorescent antibody technique, using p3hr-1 cells as the target. high anti-vca antibody titer in patients with npc was found beginning to decline at the end of radiotherapy. most (66.7%) of the patients were found to have a detectable reduction in an ... | 1977 | 189741 |
| [tumors caused by viruses]. | 1977 | 190098 | |
| transient induction of a nuclear antigen unrelated to epstein-barr nuclear antigen in cells of two human b-lymphoma lines converted by epstein-barr virus. | infection of cells of the epstein-barr virus (ebv)-negative human b-lymphoma lines bjab and ramos with ebv preparations from p3hr-1 or b 95-8 cells converted these cells to ebv genome carriers expressing epstein-barr nuclear antigen (ebna) in almost 100% of these cells. induction of these cells as well as of clones from p3hr-1 ebv-converted bjab cells with iododeoxyuridine, aminopterin, and hypoxanthine resulted in the appearance of a nuclear antigen in about 1-6% of the cells 1-4 days after ind ... | 1977 | 189313 |
| [burkitt's lymphoma]. | 1977 | 189235 | |
| heterogeneity of epstein-barr virus originating from p3hr-1 cells. i. studies on ebna induction. | infection of ebv-negative human b-lymphoma cells of the lines bjab and ramos with ebv from p3hr-1 or b95-8 cells resulted in gradual conversion of these cells to ebna synthesis. whereas b 95-8 virus-infected cells exhibited a uniform brilliant ebna fluorescence, two distinct fluorescence patterns were observed in p3hr-1 virus-converted bjab and ramos cells, a faint granular and a brilliant fluorescence, with predominance of the faint granular pattern. cloning of p3hr-1 virus-converted bjab cells ... | 1977 | 191406 |
| lymphocyte responses to ebv-associated antigens in infectious mononucleosis, and hodgkin's and non-hodgkin's lymphoma patients, with the leukocyte adherence inhibition assay. | the leukocyte adherence inhibition (lai) assay was utilized as a test for cellular immunity to epstein-barr virus (ebv) antigens in 22 patients with infectious mononucleosis (im), 47 patients with lymphoma, 101 carcinoma patients, and 84 subjects without cancer. response to eb virion ("v") antigen was generally present at the time of diagnosis in the im patients but the response to eb soluble ("s") antigen was delayed. an increased cmi response to "v" antigen was found in patients with im, hodgk ... | 1977 | 191408 |
| epstein-barr virus antibodies in tonsillar carcinoma patients;. | sera from 18 tonsillar carcinoma patients and from 18 matched control subjects were examined for the presence of antibodies to viral capsid antigen (vca), early antigen (ea) and nuclear antigen (ebna) of eb virus. antibodies to all three antigens were found more frequently and in significantly higher titres in the tonsillar carcinoma patients than in control subjects. | 1977 | 191412 |
| column separation of viral capsid antigen (vca)-positive cells from vca-negative cells in an epstein-barr virus (ebv)-producing lymphoid line,. | virus producing, vca (viral capsid antigen)-positive cells could be selectively removed from epstein-barr virus (ebv)-carrying, virus-producer p3hr-1 cultures by two different methods of column passage. in the first, the virus-producing cells were covered with human ebv antibody and subsequently passaged through anti-human-ig columns. in the second methods, untreated p3hr-1 cells were allowed to pass through columns of ebv receptor-positive cell lines or, as controls, ebv receptor-positive cell ... | 1977 | 191413 |
| endogenous reactivation of epstein-barr virus infections. | in a prior systematic community survey, 20 adults were found to have antibodies to viral capsid antigen (vca) and early antigen (ea) of epstein-barr virus (ebv) in serum. the presence of the latter antibody suggested a recent response to ebv. in the present study the significance of antibody to ea was more extensively evaluated by examination of the sera of these adults for the presence of ebv-specific igm antibodies (ebv-igm) and antibodies to ebv nuclear antigen (ebvna). sera of a matched grou ... | 1977 | 191540 |
| effect of adenine arabinoside on epstein-barr virus in vitro. | the effect of adenine arabinoside (ara-a) on epstein-barr virus (ebv) in cultures of lymphoid cells was examined with use of an ebv-producing cell line, p3hr-1, and a nonproducing cell line, raji. the presence of ebv-associated viral capsid antigen (vca) and early antigen (ea) was detected by indirect immunofluorescence. ara-a inhibited the expression of vca in p3hr-1 cells at concentrations fivefold below those that inhibited cell multiplication; there was no concomitant accumulation of ea. ara ... | 1977 | 191542 |
| relationship between amount of epstein-barr virus-determined nuclear antigen per cell and number of ebv-dna copies per cell. | 1977 | 191759 | |
| problems in the diagnosis and treatment of infectious mononucleosis. | 1977 | 191799 | |
| host-determined differences in expression of surface marker characteristics on human and simian lymphoblastoid cell lines transformed by epstein-barr virus. | in an attempt to account for differences in the biologic behavior of epstein-barr virus in different primate species, we studied lymphocyte surface markers on primary and transformed cells. among primary leukocytes, the distribution of cells with characteristics of bone-marrow-derived cells (b cells) was similar in humans, wooly monkeys, and cotton-top marmosets. however, after transformation by epstein-barr virus, cells from each species were characterically different. transformed human umbilic ... | 1977 | 191824 |
| predictors of the duration of infectious mononucleosis. | the clinical course of infectious mononucleosis was monitored in 122 patients to determine predictors of duration of illness. gastrointestinal symptoms and palatal petechiae were associated with a prolonged recovery period. multiple regression analysis of quantitative data identified the number of days from onset of symptoms to diagnosis as the only statistically significant indicator. liver enzymes, white blood cell count, percentage atypical lymphocytes and heterophil titer had no prognostic v ... | 1977 | 191934 |
| infectious mononucleosis: seasonality in wisconsin. | 1977 | 191996 | |
| [immunoglobulins and sheep red cell receptors in human lymphoblastoid cell lines simultaneously carrying epstein-barr virus and cytomegalovirus genomes]. | in this communication we attempt to characterize the principal immunological properties of 3 human lymphoblastoid cell lines (lcl) established in our laboratory which carry both the ebv and cmv genomes. the data obtained suggests that two lcl are representative of b lymphocytes while the other lcl has a mixed cell population with the majority being of the b type. the reasons for this heterogeneity are discussed. it is suggested that cmv may also transform thymus-independent (b) lymphocytes. | 1977 | 192131 |
| [tumour antigens inducing immune reactions]. | antigens of viral tumours are the same for all the tumours due to the same virus. antibodies in tumours bearing animals allow to detect antigens in nucleus, in cytoplasm and on the cell membrane which carries also embryonic antigens and the antigen responsible for tumour rejection by sensitized lymphcytes (tsta or tata). is this antigen identical to the surface antigen shown by antibodies? purification of membrane antigens will answer this important question. chemically induced tumours bear tumo ... | 1977 | 192132 |
| cold lymphocytotoxic antibodies in nasopharyngeal carcinoma. | sera from patients with nasopharyngeal carcinoma (npc), a disease associated with epstein-barr virus (ebv), were found to be cytotoxic at 15% degrees c in the presence of complement for a panel of human lymphocytes, with a higher frequency than those of matched controls. the cold lymphocytotoxic antibodies (lta) responsible for this activity have the same properties as those described in sera from individuals with acute viral infections. the frequency and geometric mean titres (gmt) of lta varie ... | 1977 | 192260 |
| monozygotic triplets with discordance for diabetes mellitus and diabetic microangiopathy. | a set of monozygotic triplets (pe.k., p.k., s.k.) has been studied. there is no diabetes in first-degree relatives. pe.k. developed insulin-requiring (60 u. nph) diabetes at the age of 13 years. over a period of 11 years since that time, numerous studies of insulin and growth-hormone secretion were performed on p.k. and s.k., including multiple oral glucose tolerance tests (ogtts), cortisone-primed oral glucose tolerance tests (c-ogtts), intravenous glucose tolerance tests (ivgtts), and intraven ... | 1977 | 192616 |
| lymphoma in cotton-top marmosets after inoculation with epstein-barr virus: tumor incidence, histologic spectrum antibody responses, demonstration of viral dna, and characterization of viruses. | 6 of 20 cotton-top tamarins (saguinus oedipus) inoculated with epstein-barr virus (ebv) developed diffuse malignant lymphoma resembling reticulum cell or immunoblastic sarcoma of man. hyperplastic lymphoreticular lesions were induced in three additional animals; in two instances the hyperplastic lesions regressed. inapparent infection with development of antibody occured in eight animals. in two animals there was no evidence of ebv infection. one animal died in the first week after inoculation o ... | 1977 | 192829 |
| epstein-barr virus genome studies in burkitt's and non-burkitt's lymphomas in uganda. | burkitt's lymphoma (bl) has been widely investigated and has attracted attention because of the possible etiologic role of the epstein-barr virus (ebv). to further determine the role of ebv in the causation of this tumor, we measured ebv-specific nuclear antigen (ebna) and ebv dna using immunofluorescence and nucleic acid hybridization techniques, respectively. of 34 bl biopsies, 27 tissues (79%) were ebna-positive, whereas none of the 25 non-bl biopsy tissues were ebna-positive. of 15 bl tumors ... | 1977 | 192894 |
| a solid-phase radioimmunoassay for epstein-barr virus-associated membrane antigen prepared from b95-8 cell culture supernatants. | epstein-barr virus(ebv)-associated membrane antigen (ma) was concentrated from b95-8 cell culture media by precipitation with polyethylene glycol followed by chromatography on bio-gel a-50m. in a raji cell-binding assay, ma-positive material could only be found in the void volume of the column. after ultracentrifugation all antigenic activity appeared in the pellet, which suggested that ma was present in aggregates, presumably fragments of cellular membranes and/or virus envelopes. the ma-contai ... | 1977 | 192896 |
| activation of epstein-barr virus in hybrid cells. | human-primate hybrid cell lines were established by fusion of african green monkey kidney cells (vero) with lymphoblastoid cells from patients with infectious mononucleosis (im)(imk101) and from burkitt's lymphoma culture (hr1k). both epstein-barr virus (ebv)-specific antigens and ebv particle-containing cells increased in the hybrid lines (imk1-1/vero,hr1k/vero). treatment of the hybrids with 5-bromodeoxyuridine induced more antigen-positive and more virus-containing cells. ebv could be activat ... | 1977 | 192898 |
| solubilization of the epstein-barr virus-determined nuclear antigen and its characterization as a dna-binding protein. | the eptstein-barr virus (ebv)-determined nuclear antigen (ebna) was solubilized from isolate nuclei of two ebv-transformed cell lines- raji and aw-ramos, by high-salt treatment. its dna-binding properties were studied by dna-cellulose chromatography and a 51cr release complement fixation assay. ebna binds to both double-stranded and single-stranded calf thymus dna, showing a higher affinity to double-stranded dna. there was no detectable difference in the dna binding of ebna prepared from raji a ... | 1977 | 192908 |
| [epstein-barr virus (ebv) in lymphoid cells--a human tumor virus?]. | 1977 | 192982 | |
| polyclonal ig production after epstein-barr virus infection of human lymphocytes in vitro. | 1977 | 193041 | |
| [malignant nasopharyngeal tumors at an early age]. | 1977 | 193058 | |
| neoplasms of the nasopharynx in children. | neoplasms of the nasopharynx are rare in children, but they threaten the child's life when they do occur. the nasopharynx tends to harbor dysontogenetic neoplasms. after classification into benign and malignant groups, nasopharyngeal neoplasms in children can be further characterized according to the age of the patients in which the clinical manifestations usually appear. dermoids and teratomas are the most frequently encountered neoplasms of the nasopharynx in infants and may produce airway obs ... | 1977 | 193080 |
| [current problems posed by viruses of the herpes group]. | 1977 | 193083 | |
| epstein-barr virus dna synthesized in superinfected raji cells. | 1977 | 193261 | |
| further studies on the differences in serum dependence in ebv negative lymphoma lines and their in vitro ebv converted, virus-genome carrying sublines. | 1977 | 201467 | |
| chromosome banding, isoenzyme studies and determination of epstein-barr virus dna content on human burkitt lymphoma/mouse hybrids. | four independently fused hybrid clones derived from a cross between the mouse mammary carcinoma ta3ha and the human burkitt lymphoma line daudi were tested for the ebv-determined nuclear antigen (ebna), ebv-dna and the presence of human chromosomes, in the course of serial propagation in vitro. ebna and ebv-dna were lost in parallel with the loss of human chromosomes. it seems that the persistence of eb-viral genetic information does not require the presence of a specific human chromosome(s) in ... | 1977 | 201572 |
| mechanism of the establishment of epstein-barr virus genome-containing lymphoid cell lines from infectious mononucleosis patients: studies with phosphonoacetate. | a concentration of disodium phosphonoacetate (pa) has been defined which will reduce the synthesis of infectious eb virus in a producer cell line to 1% of control values but which will not affect the growth of eb virus-transformed cells in a 12-week colony-forming assay. when total mononuclear cells or t-lymphocyte-depleted mononuclear cells from the blood of acute im patients were cultured in the presence of pa at the above concentration, the regular establishment of eb virus genome-containing ... | 1977 | 201573 |
| ebv specific secretory iga in saliva of npc patients. presence of secretory piece in epithelial malignant cells. | saliva samples from 59 patients with nasopharyngeal carcinoma (npc) and from 20 normal individuals were studied to determine the nature and origin of the ebv-specific iga in npc saliva. about 50% of npc saliva samples contained secretory iga specific for ebv. the corresponding tumor iga(alpha) was found in plasma cells surrounding the epithelial tumor cells and the secretory piece at the surface of epithelial cells. a slightly higher proportion of npc saliva samples containing iga was found in p ... | 1977 | 201574 |
| non-random chromosome gains in human lymphoblastoid cell lines. | 1977 | 201860 | |
| possibility of eb virus preferentially transforming a subpopulation of human b lymphocytes. | 1977 | 201868 | |
| [epstein-barr virus as an etiological factor in infectious mononucleosis and other diseases]. | 1977 | 201912 | |
| the glandular fever syndrome revisited. | 1977 | 201932 | |
| persistent infection and viral carrier state of a human lymphoblastoid cell line infected with mumps virus before its transformation. | 1977 | 202295 | |
| a case of an epstein--barr virus (ebv) genome-carrying lymphoma in an israeli arab child. | 1977 | 202470 | |
| [chromosomes of 7 transplantable lines of macaque and pavian hematopoietic cells producing herpesvirus type ebv and oncornavirus type c]. | karyotypes of su-1, su-2, kmma-1, and kmma-2 (producing oncornavirus c-type), and kmpg-1, spf-2, and spg-3 (producing hsv, a virus of ebv type) cell lines were studied in the time course. the lines were derived from hemopoietic cells of brown macaques and baboons bearing lymphomas. some of the lines had a paradiploid-pseudodiploid karyotype, another part aneuploid type. the selectivity of structural and numerical abnormalities of chromosomes 1, 9, 10, 11, 12, 13, 15, 18, and 20 was detected indi ... | 1977 | 203114 |
| nasopharyngeal cancer in greenland. the incidence in an arctic eskimo population. | nasopharyngeal cancer is very common among the chinese in various parts of the world, particularly southern china, and frequent in certain other mongoloid groups in southeast asia. also, the incidence among the eskimos of the western canadian arctic and alaska is considerably higher than would be expected. ths paper reports for the first time the incidence of nasopharyngeal cancer among native greenlanders, an eskimo population with some admixture of caucasian blood. during 1955-1976, thirty-fiv ... | 1977 | 203161 |
| blastogenic response of purified human t-lymphocyte populations to epstein-barr virus (ebv). | the blastogenic response of t-cell populations to infectious ebv (b95-8 strain) was studied. the addition of virus increased the [3h]thymidine uptake of unfractionated lymphocytes from seropositive and seronegative subjects, and from cord blood, but not from patients with infectious mononucleosis. the same amount of virus evoked a small response in purified t cells from seropositive donors, but not in t cells from the other sources. the addition of autologous b lymphocytes with ebv adsorbed on t ... | 1977 | 203426 |
| [lymphoma and eb virus]. | 1977 | 203730 | |
| [infectious mononucleosis (author's transl)]. | 1977 | 203731 | |
| antibody to epstein-barr virus in patients with carcinoma of the nasopharynx. | 1977 | 204823 | |
| heterophil-negative infectious mononucleosis and mononucleosis-like illnesses. laboratory confirmation of 43 cases. | 1977 | 204189 | |
| established cell lines as tools in the study of human lymphoma and myeloma cell characteristics. | 1977 | 204545 | |
| characterization of "t" and "non-t" cell lines established from children with acute lymphoblastic leukemia and non-hodgkin lymphoma after leukemic transformation. | 1977 | 204546 | |
| establishment and characterization of a truly leukaemic cell line. | 1977 | 204547 | |
| characterization of a human hodgkin cell line and a lymphoblastic ebna-negative cell line derived from a non-hodgkin lymphoma patient. | 1977 | 204548 | |
| autoradiographic detection of the epstein-barr virus (ebv)-associated early antigen (ea) in lymphoblastoid cell lines. | 1977 | 204549 | |
| lymphoid cell lines: in vitro cell markers in correlation to tumorigenicity in nude mice. | tumorigenicity of lymphoid cell lines of different origin upon xenotransplantation (s.c. and i.m.) in cell concentrations of 1 x 10(6) cell/inoculum into nude mice was correlated to karyotype, presence of the 14 q + marker, ebv reactivity and immunological markers. lymphoblastoid cell lines (lcl), lacking the 14 q + marker failed to produce tumors independent upon diploidy or aneuploidy. lymphoma-type lines of burkitt lymphoma, lymphosarcoma and hodgkins disease-origin, genotypically aneuploid, ... | 1977 | 204550 |
| non-hodgkin lymphomas: cell populations and functional behavior. | 1977 | 204551 | |
| [studies on the etiology and course of acute virus hepatitis: analysis of hbs-antigens, anti-hbc, ebv and cmv antibodies]. | 1977 | 206062 | |
| selected observations on the epidemiology of pharyngeal cancers. | the epidemiology of nasopharyngeal cancer (npc) has been compared with that of other pharyngeal cancers in los angeles county. epstein-barr virus (ebv) antibody titers were elevated in caucasians with pharyngeal squamous cell carcinomas regardless of subsite. as expected, an excess of npc cases was found among chinese. the role of various etiologic factors in npc including ebv, inhaled carcinogens, and salted fish was discussed. | 1977 | 206840 |
| [relations between malaria and burkitt's lymphoma]. | malaria, especially forest malaria, is the environmental factor which creates endemic conditions for the esptein-barr virus related burkitt's lymphoma. the plasmodium seems active through a mitogenic factor rather than through the so often invoked immunological depresssion. | 1977 | 208788 |
| infection of taiwan monkey t and b cells with epstein-barr virus. | in order to establish taiwan monkey lymphoblastoid cell lines, attempts were made to raise the susceptibility of monkey lymphocytes to epstein-barr virus (ebv) by chemical and enzymatic treatments. ebv infectivity to monkey t and b cells were tested by detection of ebv early antigens in infected cells with the indirect immunofluorescent antibody technique. treatments of monkey unfractionated lymphocytes with deae-dextran (160 microgram/ml) for 1 hr, ethylenediamine tetra-acetic acid (edta, 0.5%) ... | 1977 | 211014 |
| replication of epstein-barr virus: ultrastructural and immunofluorescent studies of p3hr1-superinfected raji cells. | we have studied by means of electron microscopy and immunofluorescence the different steps of the replication of the p3hr1 strain of epstein-barr virus in raji cells. the virus entered the cell by fusion of the viral envelope with the plasma membrane, followed by the disintegration of the capsid. in some cases, the migration of nucleocapsids toward the nuclear membrane was observed. the synthesis of new virions began as early as 7 h after infection (in the case of a high multiplicity of infectio ... | 1977 | 201779 |
| [eb virus infections]. | 1977 | 204712 | |
| epstein-barr virus antibodies and histocompatibility type in multiple sclerosis. | 1977 | 210555 | |
| [t- and b-lymphocyte determination in infectious mononucleosis]. | in 12 children with infectious mononucleosis the peripheral blood t- and b-lymphocytes were studied and compared to a control group of 26 children, aged 2 to 13 years, without any infection. spontaneous sheep red blood cell rosettes were used as a t-cell marker, demonstration of surface immunoglobulins by immunofluorescence technique was used as a b-cell marker. patients with infectious mononucleosis showed a marked increase of t-lymphocytes (percentage and absolute numbers) in comparison with t ... | 1977 | 328360 |
| [post-transfusion hepatitis 1973 and 1974 in the zürich region]. | more than 100 000 units of blood were tranfused during the years 1973-74 in the region of zurich. 30 cases of posttransfusion hepatitis (pth) reported in this period were investigated with regard to the origin of the tranfused blood, and 24 (71%) proved to be hepatitis b antigen (hbs-ag) positive. despite the use of a sensitive method for hbs-ag screening, transfusion of hbs-ag positive blood was found to be responsible for pth in 4 cases only. in 88% of the cases there was no proof that the pth ... | 1977 | 834982 |
| hematopathology and pathogenesis of the x-linked recessive lymphoproliferative syndrome. | subtle immunodeficiency to infectious agents including measles virus and ten epstein-barr virus (ebv) has been described in the x-linked recessive lymphoproliferative syndrome. this syndrome has affected six male cousins and possibly another boy. three brothers died of an infectious mononucleosis syndrome, in a maternal cousin agammaglobulinemia developed three years after infectious mononucleosis, and two half-brothers of the duncan kindred died of lymphoma of the brain and intestinal tract, re ... | 1977 | 835602 |
| [neurological complications of infectious mononucleosis (author's transl)]. | the authors report three different and rare forms of neurological complication associated with infectious mononucleosis. the first two, which are faily unusual in their clinical signs, occurred during the course of two typical cases of mononucleosis, one in the form of progressively regressive myelitis and the other in that of amyotrophic paralysis of the shoulder. the third occurred in isolation, after an encephalitic attack combined with a state of epileptic mal, with no other accompanying inf ... | 1977 | 842275 |