Publications

factors affecting the in vitro culture of plasmodium falciparum and plasmodium knowlesi.	plasmodium falciparum and plasmodium knowlesi have been established in continuous culture using the basic method of trager & jensen. various parameters of the culture system have been examined, namely, the gas requirements, serum and red cell requirements, frequency of medium replacement, and a comparison of static and agitated cultures made. the most important factors affecting growth in vitro seem to be the oxygen tension, red cell concentration, the frequency with which old medium is replaced ...	1979	120767
immunization of experimental monkeys against plasmodium falciparum: use of synthetic adjuvants.	the replacement of freund's adjuvant by a possible safe adjuvant for effective immunization of owl monkeys (aotus trivirgatus griseimembra) against a human malaria parasite, plasmodium falciparum, has been investigated. experiments involved the use of two synthetic adjuvants: mdp (n-acetylmuramyl-l-alanyl-d-isoglutamine) and stearoyl-mdp (6-o-stearoyl-n-acetylmuramyl-l-alanyl-d-isoglutamine). in both cases, p. falciparum merozoites obtained through short-term in vitro cultivation were used as an ...	1979	120768
malaria vaccination with irradiated sporozoites: serological evaluation of the antigen and antibody responses.	vaccination against plasmodium falciparum with attenuated sporozoites is the goal of the us navy's malaria vaccine program. one requirement in the development of this vaccine is an immunological test to study the sporozoite antigen and immune responses it induces. using an indirect fluorescent antibody test (ifat) and p. berghei in the mouse or rat as a model, we have made significant progress toward this goal. four antigens were detected in vaccine preparations: sporozoite-specific antigens, mo ...	1979	120769
in vitro inhibition of the growth of plasmodium falciparum by aotus serum.	an in vitro assay for measuring growth and reinvasion inhibition of plasmodium falciparum was developed from a microculture system. inhibition of growth was observed after parasites had been incubated with aotus serum obtained from monkeys that had become immune to malaria after repeated exposure to p. falciparum. immune aotus serum (ias), at concentrations as low as 1.25%, showed a marked inhibitory effect upon parasites cultured in 10% normal human serum (nhs). growth was also inhibited when 5 ...	1979	120771
a study of cellular and humoral immune responses in owl monkeys (aotus trivirgatus) following vaccination against plasmodium falciparum.	vaccination of animals against malaria parasites is thought to induce two basic immunological responses: (i) specific recognition of parasite antigens by the host, and (ii) a generalized immune enhancement due to the presence of adjuvant. immunological techniques were used in this study to monitor cellular and humoral immune changes in owl monkeys prior to and following immunization with a vaccine consisting of merozoite-enriched schizonts of plasmodium falciparum and one of three adjuvants: n-a ...	1979	120772
use of attenuated sporozoites in the immunization of human volunteers against falciparum malaria.	three human volunteers were successfully protected against sporozoite challenge by immunization with attenuated sporozoites of the tamenie strain of plasmodium falciparum from ethiopia. the immunizing sporozoites were attenuated by exposing infected anopheles stephensi mosquitos to x-rays at a dose of at least 120 gy (12 000 rad). these irradiated, infected mosquitos were allowed to feed upon volunteers, thereby inoculating sporozoites into their blood stream. during the 10- to 38-week period of ...	1979	120773
isolation of stages of the human parasite plasmodium falciparum from culture and from animal blood.	procedures for isolation of various forms of the asexual erythrocytic stages of the human parasite plasmodium falciparum are outlined. the procedures employ the plasma expander physiogel, which is composed of a chemically modified, partially hydrolysed gelatin dissolved in ringer's lactate. based on the observation that parasitized cells which are easily separable by this technique differ appreciably at the ultrastructural level, a mechanism by which separation occurs is proposed.	1979	120774
severe malaria and glucose-6-phosphate-dehydrogenase deficiency: a reappraisal of the malaria/g-6-p.d. hypothesis.	nigerian children with convulsions and plasmodium falciparium parasitaemia above 100,000/microliter did not show a decreased frequency of glucose-6-phosphate-dehydrogenase (g.-6-p.d.) deficiency. a re-evaluation of earlier studies has led to the conclusion that clinical evidence of protection against falciparum malaria in g.-6-p.d.-deficient individuals is lacking. evidence for the possible role of malaria in selecting for g.-6-p.d.-deficient genes consists solely of the geographical association ...	1979	85108
cause of anaemia in malaria.	51cr studies showed that after complete eradication of malarial parasites erythrocyte life-span is reduced for 4-5 weeks and that the reduction is associated with the presence of complement-containing immune complexes on the red-cell surface. the rate of erythrophagocytosis in the spleen is increased during this period. 59fe studies of erythropoiesis indicated a mild degree of marrow depression. a very important factor causing anaemia in malaria appears to be a complement-mediated immune process ...	1979	86777
the malaria/g.-6-p.d. hypothesis.		1979	86896
increasing incidence of malaria in britain.		1979	87705
fansidar resistant falciparum malaria in indonesia.		1979	89577
antigenicity of the infected-erythrocyte and merozoite surfaces in falciparum malaria.	the antigenicity of altered structures induced by plasmodium falciparum in the membranes of infected aotus monkey and human erythrocytes was examined. antisera were obtained from monkeys made immune to malaria. bound antibodies were shown to be localized on the knob protrusions of infected erythrocytes of both human and monkey origin and from both in vitro and in vivo infections. therefore, p. falciparum infection has produced similar antigenic changes in the erythrocyte surfaces of both man and ...	1979	91658
chloroquine-resistant plasmodium falciparum from east africa: cultivation and drug sensitivity of the tanzanian i/cdc strain from an american tourist.	a strain of plasmodium falciparum, designated tanzanian i/cdc, from an american tourist returning from tanzania, was isolated in vitro and in the aotus monkey. clinically, the infection showed a late recrudescent pattern of chloroquine resistance. in 2 inoculated aotus monkeys, the infection recrudesced after a dose of chloroquine (40 mg/kg) curative for sensitive p. falciparum strains in the aotus monkey. in 4 ,dditional monkeys two primary infections and one of the recrudescent parasitaemias w ...	1979	91887
chloroquine-resistant plasmodium falciparum in africa.		1979	92720
recent advances in applied malaria immunology.	our present knowledge of cellular and humoral factors which are involved in immunity to plasmodial infections are discussed. immunization against plasmodial infection has been achieved in birds, rodents, simians, and humans. avian hosts have been immunized against gametocytes which resulted in inhibition of gametocytes within the mosquito vector. immunization of humans against plasmodial gametocytes would indirectly protect them against malaria by blocking mosquito transmission to other suscepti ...	1979	93828
plasmodium falciparum: physiological interactions with the human sickle cell.		1979	33821
plasmodium falciparum: microaerophilic requirements in human red blood cells.		1979	36286
comparative studies on dihydrofolate reductases from plasmodium falciparum and aotus trivirgatus.	dihydrofolate reductase (e.c. 1.5.1.3) from plasmodium falciparum and from its host, the owl monkey (aotus trivirgatus), were partially purified and characterized. the molecular weight of the parasite enzyme was estimated to be over 10 times as high as that of the host enzyme. the host enzyme had 2 ph optima whereas the parasite enzyme only one. the activity of the host enzyme was greatly stimulated by kcl and urea, while that of the parasite enzyme was inhibited at high concentrations of such c ...	1979	44526
[imported malaria in leningrad in 1975-1977].		1979	154588
[evaluation of the repercussions on parasitic endemias (malaria, bilharziasis, onchocerciasis, dracunculosis) of the construction of 57 dams in the mandara mountains (north cameroun)].		1979	161205
[chemotherapy of infections in the third world].		1979	162323
[severe forms of imported malaria concerning three pernicious attacks and a black water fever (hemoglobinuria) (author's transl)].	four severe cases of imported malaria are reported here. three of them are pernicious and the fourth is a black water fever (hemoglobinuria). the difficulties of initial diagnosis are exposed. there was no mortality in these four cases which represent the annual recruiting of a multipurpose intensive care unit. but the complications are severe in contradiction with easy effective chemoprophylaxis. the principles of treatment and prophylaxis are resumed in the light of these four observations.	1979	230588
abnormal haemoglobins in the sudan savanna of nigeria. i. prevalence of haemoglobins and relationships between sickle cell trait, malaria and survival.	the prevalence of different haemoglobins and their interaction with malaria have been studied in garki, kano state, nigeria. sickle cell trait was present in 24% of newborn and 29% of those aged over five years. hb.ac was present in 0.7%. frequency of both haemoglobin variants was greater in hausa than fulani. sickle cell anaemia was almost invariably fatal in early childhood. the distribution curve of percentage of hb.s in sickle cell trait subjects was normal, and did not demonstrate any high ...	1979	315211
use of drugs for malaria control in tropical africa.	at present, in countries of tropical africa, chemotherapy is the main and often the only operationally, administratively, and financially feasible method of malaria control. this applies particularly in rural areas. this article reviews experience with chemotherapy in africa since the late 1940s with mepacrine, proguanil, pyrimethamine, chloroquine, amodiaquine, and sulfones and sulfonamides in combination with dihydrofolate reductase inhibitors. chloroquine has proved to be the most effective c ...	1979	316734
chloroquine-resistant falciparum malaria from africa.		1979	364085
malaria in birmingham and a london teaching hospital.	during the past five years the incidence of imported malaria increased among patients seen in east birmingham hospital and in st thomas's hospital, london. plasmodium vivax was the predominant species in birmingham, and was almost always acquired by asian immigrants visiting the indian subcontinent. in st thomas's p falciparum was most commonly imported, usually by african immigrants visiting nigeria and ghana. two patients (one irish, one japanese) died of falciparum malaria after visiting trop ...	1979	367507
severe falciparum malaria during a blizzard.		1979	367562
chloroquine-resistant falciparum malaria.		1979	368534
[course and intensive treatment of acute falciparum malaria (author's transl)].	the case of a nineteen-year-old women with the cerebral form of malaria tropica is reported. she showed hyperpyrexia, abdominal manifestations, haemolysis and disseminated intravascular coagulation. cerebral symptoms amounting to grade iv encephalopathy occurred. the patient responded rapidly to the administration of chloroquine, anticonvulsants, dextran, corticosteroids, antipyretics, blood and antithrombin iii and her symptoms had almost completely vanished one week after the onset of therapy.	1979	373259
single-dose therapy of falciparum malaria with mefloquine or pyrimethamine-sulfadoxine.	a single oral dose (1.5 g) of mefloquine hydrochloride cured all of 37 patients with falciparum malaria, and a single dose of pyrimethamine (75 mg) plus sulfadoxine (1.5 g) cured 34 of 38 patients. the rates at which parasitaemia and fever abated were similar for the two regimens but mefloquine was associated with a higher incidence of gastrointestinal side effects.	1979	373903
loss of circulating t lymphocytes with normal levels of b and 'null' lymphocytes in thai adults with malaria.	peripheral blood mononuclear cells from forty-nine thai adults infected with either plasmodium falciparum or plasmodium vivax were examined in order to determine the percentage of t, b, and fc-receptor-bearing cells present. in comparison to healthy controls, both the percentage and concentration of peripheral t cells were decreased in the malaria-infected individuals as assessed by formation of rosettes with sheep red blood cells. the percentage of peripheral b cells was increased but their co ...	1979	373935
occurrence of malaria acquired during travel abroad among american civilians, 1970-1976.		1979	374645
[malaria in switzerland. clinical diagnosis and management schedule for the practitioner (author's transl)].		1979	375456
serum immunoglobulin levels and malaria antibodies in burkitt's lymphoma.	data are presented to support a relationship between malaria infection and burkitt's lymphoma in african children. igg, igm and iga levels were measured in sera from burkitt's lymphoma patients and from sex- and age-matched, nearest-neighbour controls. all three classes of immunoglobulins were present in significantly lower amounts in the sera from burkitt's lymphoma patients than in the sera from controls. the mechanism of this apparent b-cell suppression is not yet clear. malaria-specific igg ...	1979	375487
lymphocyte changes in murine and human malaria.		1979	375510
falciparum malaria despite chemoprophylaxis.		1979	376057
urban malaria and its vectors in salem (tamil nadu): natural and induced infection with human plasmodia in mosquitoes.		1979	376440
immunizations for travelers.		1979	377044
oxidant damage mediates variant red cell resistance to malaria.		1979	377105
[transmission of plasmodium falciparum malaria by syringe in a patient with heroinism].		1979	377220
[imported tropical malaria in pregnant women].		1979	377517
[errors in the diagnosis of malaria].		1979	377805
the use of exchange transfusions: a potentially useful adjunct in the treatment of fulminant falciparum malaria.	fulminant falciparum malaria with greater than 500,000/mm3 parasites in the peripheral blood portends a poor prognosis. we recently managed a patient who had greater than 1.2 million/mm3 parasitized erythrocytes in her peripheral blood, following initially inadequate antimalarial therapy, with exchange transfusion in addition to conventional chemotherapy. this patient recovered from her disease despite severe cerebral involvement and acute failure. we feel that exchange transfusion was a useful ...	1979	377965
therapeutic use of exchange transfusion in malaria.	in the case reported here, a patient with severe plasmodium falciparum infection with 20% of erythrocytes parasitized was cured by exchange transfusion in conjunction with classical drug therapy.	1979	378004
[chloroquine-resistant tropical malaria following a trip to kenya].		1979	378630
plasmodium falciparum: continuous cultivation in a semiautomated apparatus.		1979	378679
response of sensitized and unsensitized human lymphocyte subpopulations to plasmodium falciparum antigens.	antigen preparations derived from plasmodium falciparum-infected erythrocytes (but not from uninfected erythrocytes) can stimulate the in vitro proliferation of peripheral blood lymphocytes from malaria-sensitized as well as nonsensitized donors. the possibility that the nonspecific responses might be due to a parasite-derived b-cell mitogen has been previously suggested since polyclonal hypergammaglobulinemia is a frequent accompaniment of malaria infection. to test this hypothesis, we investig ...	1979	378840
haemoglobin s and p. falciparum malaria.		1979	379655
[malaria tropica with coma in early infancy (author's transl)].	after arriving in austria a 10 month old nigerian infant fell sick with malaria tropica and survived after specific antiparasitic therapy. early diagnosis and immediate begin of treatment are stressed.	1979	380183
plasmodium gallinaceum-parasitized chicken erythrocytes in a practical hemagglutination test for igm antibodies in human malaria.	a new hemagglutination test for human malaria, done with plasmodium gallinaceum-parasitized, aldehyde-fixed, chicken erythrocytes as a stable lyophilized reagent, is described. the test was positive in every human case of falciparum or vivax malaria in which there was parasitemia. it detected only igm anti-plasmodial antibodies and usually became negative within a few weeks after treatment. as a practical and sensitive test for active malaria, the p. gallinaceum hemagglutination test should be c ...	1979	380370
fansidar for falciparum malaria.		1979	380540
falciparum malaria despite chemoprophylaxis.		1979	380749
pulmonary oedema in the falciparum malaria.		1979	380762
acute urticaria due to plasmodium falciparum infection. a report of two cases with a review of the english literature.		1979	380958
a note on in vivo chloroquine sensitivity tests in p. falciparum in some parts of karnataka state.		1979	381190
partial characterization of a malaria mitogen.	supernatants from 24-hour cultures of plasmodium falciparum-infected human red blood cells stimulated lymphocytes from both malaria immune and malaria non-immune donors. both t and b lymphocytes responded. amalaria parasite-derived mitogen may play some part in the pathogenesis of the hypergammaglobulinaemia characteristic of malaria.	1979	382464
frequency of blood group antigens in nigerian children with falciparum malaria.	the frequencies of the following blood group antigens: a, b, o, m, n, s, s, u, fya, fyb, lea, jsa and k have been determined in nigerian children with severe falciparum malaria. the frequency distribution of m, n, s, s, u, fya and fyb were not significantly different in children with life-threatening falciparum malaria and controls. the frequencies of a, b, o, lea, jsa and k found in the children with severe malaria were similar to those previously reported for healthy adults in this population. ...	1979	382466
chloroquine-resistant plasmodium falciparum malaria in kenya.	a case of chloroquine-resistant plasmodium falciparum malaria in a non-immune male is reported. primary attack came 19 days after return to a non-malarious country from a visit to kenya. recrudescences occurred three times with intervals of 30 to 33 days after standard chloroquine treatment. the who extended field test for sensitivity of falciparum malaria to chloroquine was followed by recrudescence 31 days later. treatment with fansidar terminated the infection. if continuous treatment of the ...	1979	382468
a method for large-volume cultivation of malaria parasites based on the principle of the trager-jensen culture method.		1979	382473
ultrastructural damage to the malaria parasite in the sickled cell.	the process by which malaria parasites are killed in sickled erythrocytes was studied by electron microscopy. in vitro cultures of plasmodium falciparum in sickle cell hemoglobin (hbs) homozygous (ss) and heterozygous (sa) red cells were deoxygenated for up to 6 h and fixed under anaerobic conditions. parasites in ss cells appeared to be disrupted by intrusions of needle-like deoxyhbs aggregates; disintegration of cytoplasm and membranes followed. in sa red cells, the parasites were generally no ...	1979	385855
malaria in australia.		1979	386057
chloroquine-resistant falciparum malaria.		1979	386060
[a patient with tropical malaria acquired in a south african safari park].		1979	386142
[successes of modern malariology].	malariological situation analysis in the ussr and world over testifies to increasing malaria incidence particularly in the countries where earlier it was almost fully eradicated. malaria epidemics in these countries (posteradication epidemics) is a new phenomenon in malariology. temporary success of the global campaign of malaria eradication has led to a deadlock in malariology which during the past 10 years is being successfully overcome. achievements of modern malariology are reviewed in the a ...	1979	386234
antibodies to sporozoites: their frequent occurrence in individuals living in an area of hyperendemic malaria.	serum samples from 158 west africans were tested for antibodies against sporozoites, the vector stage of the malaria parasite. antibodies specific for plasmodium falciparum sporozoites were detected by means of the circumsporozoite precipitation assay and indirect immunofluorescence. more than 90 percent of the serum samples from adults gave positive immunofluorescent reactions against falciparum sporozoites, whereas most of the samples from children gave low or negative reactions.	1979	386511
abnormal haemoglobins in the sudan savanna of nigeria. ii. immunological response to malaria in normals and subjects with sickle cell trait.	children born in areas hyperendemic for plasmodium falciparum are protected by maternal antibodies for up to about five months of life, after which they are subject to intense infection until they acquire sufficient immunity--by about five years of age. children with sickle cell trait (hb.as) are at an advantage during these critical years, probably because of preferential phagocytosis of parasitized red cells. this could lead to either (i) early processing of antigen by macrophages and an accel ...	1979	386969
studies on plasmodium falciparum in continuous cultivation. i. the effect of chloroquine and pyrimethamine on parasite growth and viability.	recent advances in the in vitro study of human malaria have provided the knowledge to maintain plasmodium falciparum in continuous culture. using relatively cheap and easily obtainable materials it is now possible to study many parameters including parasite chemotherapy. the activity of two standard antimalarials, chloroquine and pyrimethamine, has been examined in vitro. the effect on the parasite is easily observed and can be measured not only as a decrease in parasite density, but also as the ...	1979	386970
genetics of red cells and susceptibility to malaria.		1979	387115
chloroquine-resistant falciparum malaria.		1979	388167
tetraethylthiuram disulfide (antabuse) inhibits the human malaria parasite plasmodium falciparum.	plasmodium falciparum in culture grows optimally at 3% oxygen. oxygen levels down to 0.5% still support growth, but anaerobic conditions do not. these findings, and the absence of the krebs cycle in plasmodium, suggested that in this organism oxygen may not function in electron transport but rather may act through metalloprotein oxygenases. tetraethylthiuram disulfide (antabuse, disulfiram) and its reduction product diethyldithiocarbamate inhibit many metalloprotein oxygenases and have a lipid/h ...	1979	388434
characterization of a protein correlated with the production of knob-like protrusions on membranes of erythrocytes infected with plasmodium falciparum.	membranes of erythrocytes infected with plasmodium falciparum develop protrusions called "knobs." these protrusions are not apparent on erythrocytes infected with young parasites (rings) but develop with the growth of parasites to the trophozoite and schizont stages. the nature and origin of knobs were characterized by comparing the stage-specific proteins of two culture lines of p. falciparum, k+ and k-. k+ parasites produce knobs; k- parasites do not. erythrocytes infected with both types of p ...	1979	388448
possible chloroquine-resistant plasmodium falciparum in nigeria.	a 42-year-old hospital worker had a recrudescence of falciparum malaria after chloroquine therapy. further adequate treatment with chloroquine given orally did not clear the infection. he was then given a combination of sulphadiazine and pyrimethamine, which produced a radical cure. this points to the possibility of chloroquine-resistant plasmodium falciparum in nigeria, an african country where this has been thought to be unlikely. because of this and earlier reports, clinicians should be on th ...	1979	389072
the enzyme-linked immunosorbent assay (elisa) for malaria. ii. comparison with the malaria indirect fluorescent antibody test (ifa).		1979	389073
chloroquine-resistant falciparum malaria in a bangladeshi girl with acute lymphoblastic leukaemia.		1979	389343
cerebral malaria in the united kingdom.	four fatal cases of cerebral plasmodium falciparum malaria in english travellers returning from africa have been seen in the last 13 years. the haemorrhages, accumulations of microglia, and destruction of cerebral white matter around small veins as a result of blockage of cortical capillaries by parasitised red blood corpuscles resemble the effect of fat embolism. microglia in the lesions is demonstrated by special neuropathological techniques. attention is drawn to the need for a prompt recogni ...	1979	389955
[tropical malaria contracted the natural way in the netherlands].		1979	390409
[in vitro cultivation of plasmodium falciparum as a first step in the development of a malaria vaccine].		1979	390410
[demonstration of soluble parasite antigens, the corresponding antibodies and immune complexes in acute malaria].	serum levels of malaria antigens, antimalaria antibodies, immune complexes and complement components have been followed up in 23 patients suffering from acute malaria infection and recovering under therapy. malarial antigens in serum were detected by counterimmunoelectrophoresis: the peak was observed before therapy started and their levels rapidly decreased. specific antimalarial antibodies became detectable 5--7 days after starting treatment in patients with a first infection. immune complexes ...	1979	390695
exchange transfusion in cerebral malaria complicated by disseminated intravascular coagulation.	a patient with cerebral malaria complicated by full-blown dic, after failing to respond to other forms of treatment, was successfully treated by exchange transfusion. to the best of the authors' knowledge, this may be first reported case of full-blown dic in malaria successfully treated by exchange transfusion.	1979	390723
bleeding diathesis in tropical diseases.		1979	390724
synchronization of plasmodium falciparum erythrocytic stages in culture.	synchronous development of the erythrocytic stages of a human malaria parasite, plasmodium falciparum, in culture was accomplished by suspending cultured parasites in 5% d-sorbitol and subsequent reintroduction into culture. immediately after sorbitol treatment, cultures consisted mainly of single and multiple ring-form infections. at the same time, varying degrees of lysis of erythrocytes infected with the more mature stages of the parasite was evident. approximately 95% of the parasites were i ...	1979	383936
plasmodium falciparum in culture: improved continuous flow method.	a new design of flow vessel provides a method for continuous culture of p. falciparum in a settled layer of human erythrocytes with a slow flow of culture medium over them. the parasitemia is kept fluctuating from approximately 1%, just after addition of fresh erythrocytes, to approximately 10%, 2 or 3 days later. each vessel provides each week 3 harvests, each containing approximately 0.6--1 x 10(9) parasites.	1979	383969
observations on gametogenesis in plasmodium falciparum from continuous culture.	gametocytes of plasmodium falciparum were produced in continuous cultures but eventually declined in numbers after 3--4 months in vitro. their development progressed in a consistent pattern, from small rounded, through triangular, to ellipsoidal, and finally after 8 days to crescentic forms. morphologic maturity occurred at 8--9 days, but the gametocytes would not exflagellate in vitro, even after 14--18 days of development. thus, current culture methods cannot produce a continuous supply of fun ...	1979	383970
[aspects of malaria epidemiology in the people's democratic republic of yemen].		1979	384190
[pressing problems of malaria prevention in the ussr].		1979	384191
[autochtone malaria].		1979	384362
the effect of prednisolone on red cell survival in patients with falciparum malaria.	radioisotope red-cell survival studies were carried out in 20 patients with falciparum malaria following quinine therapy. the mean parasite clearance time of the patients receiving quinine sulfate was 49 hours and those of the patients receiving quinine sulfate and prednisolone was 46 hours. the red-cell survival was correlated with the initial hematocrit level in both groups but the daily dose of 40 mg prednisolone did not mitigate the red cell survival.	1979	384543
treatment of falciparum malaria in thai children.		1979	384544
in vivo and in vitro studies of quinine sensitivity of plasmodium falciparum in thailand.	forty-four patients with falciparum malaria were studied. nine patients were given quinine orally at a daily dose of 1.5 gm base for a period of 14 days. the mean parasite clearance in all 9 patients was 3.3 days, and none had recrudescence in follow-up examinations for 31 days. the in vivo study of these 9 patients showed sensitivity to quinine which correlated with the in vitro test, with concentration of quinine base 2.5-5.8 microgram/ml of blood that inhibited the maturation of plasmodium fa ...	1979	384545
[accidentally induced malaria].		1979	384632
the role of hemoglobins c, s, and nbalt in the inhibition of malaria parasite development in vitro.	the host cell competence of hemoglobin c (hbc)-containing erythrocytes for plasmodium falciparum was studied by in vitro culture. hbc homozygous red cells did not support the growth of the intracellular parasite. heterozygous cells, however, were competent. in addition, hbc increased the resistance of sicle cell hemoglobin (hbs) red cells when present in the double heterozygote, sc, cultured at low oxygen tension. this effect most likely resulted from the ability of hbc to enhance the sickling o ...	1979	384816
drug-resistant falciparum malaria among the mayongong indians in the brazilian amazon.	in april of 1977 an outbreak of falciparum malaria occurred among the mayongong indians, located at uauaris in the territory of roraima, brazil. blood specimens from 157 indians were examined for plasmodium; 62 were found to be infected. in three cases the infection was not cured with chloroquine but responded favorably to the drug combination of sulfadoxine and pyrimethamine (fansidar).	1979	384818
which prophylactic drugs for malaria?		1979	391331
haemoglobin a2 in malaria.		1979	391709
treatment and chemoprophylaxis of malaria.		1979	392489
the concentration of chloroquine in serum during short and long term malaria prophylaxis with standard and 'double' dosage in non-immunes: clinical implications.	the concentration of chloroquine in serum was analysed after one week, six weeks and one year on standard dose prophylaxis (300 mg chloroquine base once a week) and after six months on the double dose. after six weeks, the standard dose gave adequate protection against malaria. during the first weeks of prophylaxis insufficient protection might be achieved by the customary standard dose. in a double-dose group many values reached the point above which a higher incidence of side-reactions have be ...	1979	393188
in vitro response of chloroquine-resistant plasmodium falciparum to mefloquine.	the present study was conducted to evaluate the application of the in vitro microtechnique system in determining the response of chloroquine-resistant plasmodium falciparum to mefloquine.using isolates of p. falciparum from boa vista, brazil, and villavicencio, colombia, mefloquine was more than 7.7, 7.1, 7.1, and 6.4 times more effective than chloroquine in vitro at the ed(90), ed(95), ed(99), and ed(99.9) levels, respectively.	1979	393426
serum immunoglobulin concentrations, malarial and schistosomal antibodies in patients with massive splenomegaly in malawi.	serum immunoglobulin concentrations, malarial antibodies and schistosomal antibodies were measured in 33 patients with a provisional diagnosis of schistosomal splenomegaly, 16 with tss of presumed malarial aetiology and in 52 controls. igg and igm were higher in both splenomegaly groups than in the controls and igg was significantly higher in patients with schistosomal splenomegaly than in tss. although a very high igm was found more often in the tss group, there was no significant difference be ...	1979	393837
[epidemiological study of onchocerciasis and malaria in bamendjin dam area (cameroon). malacologic fauna and risks of schistosomian introduction (author's transl)].	report of survey in bamendjin dam area indicates that 25 p. 100 of the population have a blood smear positive for malaria (p. falciparum) and 80 p. 100 have a positive indirect immunofluorescent test for malaria. the vector is a. funestus. in male inhabitants 23,2 p. 100 of the snip-biopsies are positive for o. volvulus and 40 p. 100 of the indirect immunofluorescent test are positive. in female inhabitants the respective ratios are 14,4 p. 100 and 48,8 p. 100. there is no urinary or intestinal ...	1979	393936