Publications

[importance of cellular and humoral immunity factors in dysentery in children].		1976	795153
[interaction with the hep-2 epithelial cells of sh. flexneri r mutants and hybrids differing in o antigen structure].	the results of a study of the interaction of the r-mutants of sh. flexneri of various chemotypes and shigellae hybrids with a definite genetic characteristics differing by structure of the o-antigen labeled with 3h-glucose, with the cells of the hep-2 line demonstrated that the presence of the full value lipopolysaccharide structure apparently promoted the fixation of shigellae to the epithelial cells. the rough shigellae strains could retain the capacity to penetrate into the cells and to multi ...	1976	795229
[changes of various factors of nonspecific humoral immunity in acute dysentery].	the level of total enterobacterial enterotoxins of the blood serum, of beta-lysins, lysozyme activity, complement and normal antibodies were studied in 191 patients with acute flexner dysentery and in 285 patients with acute sonne dysentery, depending on the period of the disease, its severity, the treatment applied, and the species of the causative agent. the level of the nonspecific humoral immunity factors increased before the treatment and its normalization depended on the treatment applied.	1976	795232
[a study of pancrealysates of sh. flexneri 2a and sh. sonnei fractionated by filtration through sephadex g-200 and ultracentrifugation].	a high-molecular fraction of the o-antigen of sh. flexneri and sh. sonnei was isolated from the antigen complex by gel-filtration through sephadex g-200 and ultracentrifugation. the high-molecular fraction obtained by ultracentrifugation at 105000 g contained no low-molecular components.	1976	795248
[ultrastructural features of the interaction of salmonellae and shigellae with the cell].		1976	796637
[dysentery in the city of białystok in the years 1961-1974].		1976	796895
[role of colicinogenicity in the mechanism of the antagonistic action of sonne and flexner shigellae].		1976	797188
[ultrastructural changes in mucosa of the distal portion of the large intestine of patients with dysentery].	the ultrastructure of the mucosa of the large intestine was studied in 10 patients with acute dysentery. the group of patients included 7 women and 3 men aged 17--50 years. diagnosis was confirmed in all cases bacteriologically (by isolation of sonne shigella in 4 patients and flexner shigella in 6 patients). the electron-microscopy study of bioptats of the mucosa showed that in the inflammatory process all its cells--prismatic, gobletcells, and enterochromaffin -- took part, although not in the ...	1976	797360
r factors derived from shigella flexneri strains.	of 2492 shigelle flexneri strains isolated from dysenteric patients in hungary in the years 1972-1974, 767 (30.8%) were resistant to 1-5 antibiotics. resistance was due to r factors in 79.2% of the strains. fertility inhibition experiments with f specific phages showed r factors to be fi+ in 12.9% and fi- and 87.1%. of the antibiotic markers, the chloramphenicol-tetracycline resistance determinant was the most common (46.4%). chloramphenicol resistance determinants were carried out by fi- r fact ...	1976	798470
restriction and modification of shigella flexneri phages by r factors.	out of 420 r factors derived from shigella flexneri strains, 50.8% restricted escherichia coli and s. flexneri phages. phage restriction was produced both by fi- and fi+ r factors. the r factors were divided into nine groups on the basis of the efficiency of plating of s. flexneri phages. changes of phage types were produced by transferring r factors of different restrictive types. the changes offered some information concerning the evolution of phage types. studies on phage modification support ...	1976	798471
[chemotypes of "shigella flexneri" r mutants and related phage receptors. ii. -- localization of phage receptors (author's transl)].	receptor sites for phages fp3, v, p1kcvir, h+, c21, t4, t3, t7 and 6sr have been investigated, by comparing the lytic activity of these phages on r mutants of strain f6 (f6r) and of various serotypes (fh) of shigella flexneri with their inhibition by the lipopolysaccharides isolated from these mutants. the results suggest the following localizations for the receptor sites: phage fp3: lipid a-kdo; phage v: heptose or glucose; phage c21: heptose-glucose; phages h+, p1kcvir, t4 and t3: glucose; pha ...	1976	798512
[chemotypes of "shigella flexneri" r mutants and related phage receptors. i. -- chemical study of the lipopolysaccharides (author's transl)].	the f6r rough mutants isolated from shigella flexneri f6s, serotype 5b, and the fh rough mutants, derived from other serotypes of s. flexneri, were chemotyped according to the chemical analysis of their lipopolysaccharides. further, the following stages of lipopolysaccharide core biosynthesis in s. flexneri have been established: --(kdo)3--heptose--heptose--glucose--galactose; the last three stages are: either --glucose--glucosamine--glucose, or --glucosamine--glucose--glucose. the results of th ...	1976	798513
[substantiation for the kanamycin treatment of certain diseases, taking into account its concentration at the sites of localization of the causative agent (an experimental study)].	kanamycin concentration in the inflammatory foci was studied on experimental models of pneumonia, maxillary sinusitis and acute dysentery. the kanamycin levels in the sites of the pathogen localization were lower than those in the same tissues of healthy animals. the antibiotic dose should be chosen with the account of its concentration in the focus of the pathogen localization rather than in the blood serum.	1976	798542
[antibodies to enteropathogenic bacteria in the saliva of patients with different forms of acute intestinal diseases and healthy subjects].		1976	799368
[production and characteristics of glycerin mutants of s. typhimurium].	s. typhimurium glycerine mutants-gly 90 and gly 87 were obtained under the action of ethylmethanesulfonate. the mutants obtained were characterized by the site of block in the course of glycerine utilization:gly 90 mutant bore the mutation in the glp k-gene, this leading to the defect by glycerokinase-the enzyme of the first stage of glycerine metabolism; gly 87 mutant had derangements in the other stage of glycerine utilization. both mutants lost their capacity to induce keratoconjunctivitis in ...	1976	799451
[distribution of lysotypes and study of antibiotic sensitivity of shigella flexneri 2 isolated in iran].	152 strains of shigella flexneri 2 isolated from the stools of patients having sporadic bacillary dysenteria have been studied for their phage types as well as for the presence of transferable resistance factor. the distribution of the phage types has shown a high predominance of lysotype 12 (67%). proportion of shigella flexneri 2 strains resistant to one or several antibiotics has been highest in the years 1968 and 1973. the most frequent transferable resistance pattern was found to be (tc, cm ...	1976	799541
generalized transduction of shigella flexneri by converting phage pe5.	phage pe5, responsible for the conversion of type v antigen in shigella flexneri, has the ability to produce generalized transduction. the correlation between phage multiplicity and the number of transductants, the specific inhibitory activity of anti-pe5 serum, and the lack of transduction in pe5 resistant recipients, indicate the role of phage pe5 in generalized transduction. transduction of the r100-1 factor resulted in a non-transmissible tetracycline resistance segragation. the characterist ...	1976	799898
resistance to antibiotics of shigella strains isolated in somalia.	the resistance to antibiotics of 240 shigella strains isolated in somalia from 1973 to 1976 was studied. many strains, particularly those of shigella dysenteriae type 1, were found to be resistant to more than one drug. in view of their resistance to ampicillin, chloramphenicol, streptomycin, tetracycline, and sulfonamides, it is suggested that polymyxin b or m sulfate - which have proved to be effective in vivo - should be used for the treatment of clinically typical cases of bacillary dysenter ...	1976	799953
[researches on antibiotic-resistance in "shigella sonnei" and "flexneri" and in "salmonella typhimurium" (author's transl)].	ampicillin (a), streptomycin (s), aminosidin (k), chloramphenical (c) and tetracycline (t) resistance was investigated in 130 s. typhi murium, 18 shigella flexneri and 13 shigella sonnei strains, recovered from enteritis cases in 1970-1973. all salmonella and 70% shigella strains (without any appreciable differences between sh. sonnei and flexneri) were found resistant and most multiresistant. a-s-k-c-t resistance was frequently found: in 48% of the salmonella and 12% of the shigella strains. as ...	1976	800942
gastro-enteritis in egypt, certain epidemiological aspects.		1976	801623
scanning electron microscopic studies on the microstructure of s and r type colonies of salmonella and shigella groups.		1976	802350
diagnostic value of indirect hemagglutination in the seroepidemiology of shigella infections.	to evaluate the usefulness of the indirect hemagglutination (iha) test in the epidemiological investigation of shigellosis, single serum specimens were tested from 50 patients with shigella dysenteriae 1 (shiga bacillus) infections, 103 asymptomatic contacts of these cases, 267 adult and 100 student control, and serum specimens collected during two outbreaks caused by s. sonnei and one outbreak due to s. flexneri 6. in patients with s. dysenteriae 1, 74% demonstrated titers of greater than or eq ...	1976	767361
[intestinal localization of shigellae in dysentery and experimental shigellosis].	the investigation of 53 section cases of dysentery and 18 biopsy specimens of the large intestine in acute dysentery in children showed that intrapithelial distribution of shigella was not always regular. in studies of experimental shigellosis on isolated loops of the intestine 459 segments of the intestine of 51 rabbits were investigated. the results obtained showed that shigella multiplied mainly in the lumen of the intestine. the increase in number of shigella in enterocytes was by 8-9 orders ...	1976	769758
generation of superoxide anion and chemiluminescence by human monocytes during phagocytosis and on contact with surface-bound immunoglobulin g.	extent of o-2-release and chemiluminescence, attributed to singlet oxygen, has been compared in human monocytes and neutrophils during phagocytosis, stimulation by the surface-active agent phorbol myristate acetate, or contact with aggregated igg in a model of immune complex disease. monocytes generated o-2-and chemiluminescence with each of the three stimuli, although values were significantly less than those of neutrophils from the same individuals. lymphocytes had no significant activity in e ...	1976	178824
an in vitro system for studying insulin release caused by secretory granules-plasma membrane interaction: definition of the system.	1. an in vitro system is described in which insulin beta-granule-plasma membrane interaction can be studied. 2. the system shows an absolute requirement for physiological amounts of ca2+ (2 mum) in order for insulin release to proceed. 3. atp (5 mum) is abot to augment the ca2+ effect. 4. glucose (17 mm) alone does not cause insulin release but in the presence of ca2+ is as effective as atp. 5. when glucose, atp and ca2+ are added together a positive cooperative effect is produced with over 85% ...	1976	178856
mechanism of plasma cyclic amp response to hypoglycemia in man.	the effect of insulin-induced hypoglycemia on plasma cyclic amp levels was studied in normal volunteers, adrenalectomized, and sympathectomized subjects. significant increases in plasma glucagon were observed in all groups. normal subjects all had two- to threefold rises in plasma camp while no response was seen in any adrenalectomized or sympathectomized subject. these findings suggest that the mechanism for enhanced plasma camp release during insulin-induced hypoglycemia is catecholamine depen ...	1976	178982
[effect of migillin on protein synthesis in intact and virally infected tkce and fl cells].	the effect of migillin was studied with respect to protein synthesis in the cells of tkce (transplantable line of cells of the kidneys of cow embryos) and fl--intact and infected with viruses of aphtous fever a22, strain 550 and poliomyelitis of type iii, strain saukett respectively. simultaneously the effect of migillin on sensitivity of the cells to the above viruses was tested. the synthesis of protein was determined by incorporation of c14-glycine into the acid insoluble fraction of the cell ...	1976	179466
secretory processes, carbohydrate and lipid metabolism in isolated mouse hepatocytes. aspects of regulation by glucagon and insulin.	the procedure of berry and friend for isolation of intact hepatocytes has been adapted to mouse livers. the ultrastructure of these cells was satisfactorily preserved. isolated mouse hepatocytes secreted proteins and triacylglycerols. these secretory processes were inhibited by colchicine, indicating a likely involvement of the microtubular system for their normal occurrence. ultracentrifugation of medium incubated with hepatocytes, followed by electrophoresis and electron microscopic examinatio ...	1976	179577
intracellular forms of epstein-barr virus dna in human tumour cells in vivo.	tumour biopsies from burkitt lymphoma patients, as well as human nasopharyngeal carcinoma cells growing in athymic mice, contain epstein-barr virus dna as covalently closed circular dna. in addition integrated viral dna sequences seem to be present.	1976	176597
[pharmacology of airway mechanics].		1976	176708
effects of cytochalasin b on herpes simplex virus type 1 replication.		1976	176798
[synthesis of virus-specific macromolecules and virion maturation in chick embryo cells infected with sendai virus].	synthesis and accumulation of virus-specific rna, proteins and intracellular nucleocapsids are observed in sendai virus-infected chick embryo cells for approximately 2 days postinfection. however, only an insignificant part of these products leaves the cell as a result of maturation of virus particles. it is suggested that the cause of the ineffective maturation of virions in the system under study may be in the observed instability of one of virus structural proteins in the infected cells, m pr ...	1976	176819
stimulatory actions of thyrotropin and dibutyryl cyclic amp on transcription and translation in the regulation of thyroidal protein synthesis.	when beef thyroid cells were incubated with thyrotropin and then tested for protein synthesizing activity, the stimulatory effect of thyrotropin appeared in two distinct phases: first, an immediate stimulation which continued as long as thyrotropin was present, but died away promptly after withdrawal of the added thyrotropin; and second, a delayed stimulation with a lag period of 1 to 2 h, which persisted after thyrotropin withdrawal. the fast and the delayed effects each stimulated protein synt ...	1976	177054
immunodeficiency in the chicken. iv. an immunological study of infectious bursal disease.	chickens inoculated orally with infectious bursal disease virus (ibdv) 1 day after hatching subsequently showed a 50% incidence of immunodeficiency but little mortality. antibody responses against ibdv and to immunization with sheep red blood cells (srbc) or human serum albumin (hsa) were suppressed. serum igg concentration was decreased while igm occurred exclusively in its 7s monomeric form (migm). an allotypic marker of chicken igm (mla) was lacking in migm derived from ibdv-infected birds. t ...	1976	177236
hepatomas in grs/a male mice treated with horse serum or horse anti-mouse antilymphocyte serum.		1976	177290
[epidemiology of human and animal brucellosis in western africa. the results of six studies in the ivory coast, upper volta, and nigeria].	brucellosis has a two-fold importance in public health: the transmission of the disease to man by contact with animals or ingestion of raw milk is of direct importance; of indirect importance is the loss of animal protein. the authors have carried out ten epidemiological investigations in different bio-climatic zones of west africa. more than 120 villages were evaluated. in each village, 100 persons were chosen at random and all or part of the animal population was also studied. three tests were ...	1976	177324
endonucleolytic cleavage of murine leukemia virus 35s rna by microsome-associated nuclease.		1976	180996
effect of fluorosteroids on drug response and metabolism.		1976	181004
pseudogout: session iii. pathology of cppd crystal deposition: discussion.		1976	181018
augmented immunogenicity of tumor cell membranes produced by surface budding viruses: parameters of optimal immunization.	membranes prepared from tumor cells infected with surface budding viruses are much more immunogenic than membranes from uninfected tumor cells. factors affecting immunization with membranes from virus-infected tumor cells were studied. preparations made with influenza virus were clearly superior to those prepared with vesicular stomatitis virus (vsv). membranes infected with vsv were maximally immunogenic at a dose equivalent to a 10% cell pack whereas influenza-virus-infected membranes were imm ...	1976	182646
[infection of hela cells by herpes virus of horses type 1 in different temperature and dose of the virus (author's transl)].		1976	183896
histochemistry of oxidative enzymes in experimental allergic encephalomyelitis.	the histoenzymic pattern of oxidative enzymes (g3pd, idh, sd, g6pd,hbd, nadph: dehydrogenase) was investigated in experimental allergic encephalomyelitis (eae) produced in rats according to paterson [13]. the results obtained lead to following conclusions: (1) the neuroglia, including the white matter oligodendroglia of immunized rats, exhibits increased oxidoreductase activities; (2) the neuroallergic reaction induces some stimulation of the oxidoreductive metabolism of oligoden-droglia; (3) th ...	1976	186370
[infections transmitted in swimming pools].	public swimmingpools can be the source of infections due to micro-organism such as mycobacterium balnei, adeno and enteroviruses, the virus of plantar warts and molluscum contagiosum, the tric-agent of swimmingpool-conjonctivitis and pathogenic fungi. the transmission of trichomonas vaginalis is considered unlikely-water of pools, supposed to present satisfactory qualities by standard controls, was found to contain pathogenic staphylococci and pseudomonas aeruginosa. effective preventive measure ...	1976	186978
transfer of parental immunity to infectious laryngotracheitis in chicks.	the transfer of parental immunity to infectious laryngotracheitis was appraised by measuring serum antibody levels in 150 chicks from the day of hatch up to five weeks. the breeder flock which had received primary vaccination at eight weeks and a booster at 20 weeks transferred high antibody levels which fell markedly within two weeks and remained constant thereafter. chicks whose parents were vaccinated at 20 weeks only, had low antibody levels throughout. these low levels, in either group of c ...	1976	187298
humoral host defense mechanisms against tumors.		1976	176124
unrelated animal viruses share receptors.		1976	175292
mononucleosis-associated subacute sclerosing panencephalitis.	a thirteen-year-old girl died of subacute sclerosing panencephalitis (sspe) which occurred as part of a complex encephalitic illness related to acute infectious mononucleosis. the cerebrospinal fluid (csf) epstein-barr virus (ebv) fluorescent antibody (fa) titer was 1:64. electron microscopic examination revealed 17 nanometer (nm) diameter paramyxovirus-like nucleocapsids in brain sections and 90 nm diameter herpes virus-like enveloped particles in negatively stained brain tissue extracts. indir ...	1976	175632
immunopathogenicity and oncogenicity of murine leukemia viruses. ii. infection of mice and rats with scripps leukemia virus.	the pathologic consequences of infection of newborn mice and rats with mulv (scripps leukemia virus--slv) were observed. serum mulv p30 concentrations of most strains were elevated 20 to 100 times that of controls while mulv gp70 levels were elevated only 1.1 to 14.8 times, probably reflecting in part the higher concentrations of gp70 in control sera but also indicating the lack of parallelism in regulation of synthesis of these two viral antigens. infected mice of most strains developed immunol ...	1976	175661
coordinated, coenzyme q reversible, 2,5-dibromothymoquionine inhibition of electron transport and atpase in escherichia coli.		1976	174563
noradrenergic subsensitivity and supersensitivity of the cerebral cortex after reserpine treatment.	changes in the sensitivity of the cyclic adenosine 3', 5'-monophosphate response of rat brain cerebral cortical slices to norepinephrine were measured in vitro after the rats received i.p. injections of reserpine (1 mg/kg). subsensitivity was evident 1 hour after a single reserpine treatment compared with saline controls. however, if reserpine was injected daily for 4 days followed by 1 day without reserpine treatment, a supersensitive response to ne was shown compared to the controls. mean pd2 ...	1976	173828
a ribosome-dependent gtpase from yeast distinct from elongation factor 2.	three proteins required for poly(u)-directed polyphenylalanine synthesis have been separated from yeast. two of the factors correspond to the elongation factors 1 and 2 described for other eukaryotic systems, according to the criteria of phenylalanyl-trna binding and diphtheria toxin-catalyzed adp-ribosylation. the third protein, while absolutely required for polyphenylalanine synthesis, was a more active ribosome-dependent gtpase than elongation factor 2.	1976	174100
structural studies on d-specific polysaccharide of shigella flexneri serotype 6.		1976	173550
heterotropic interactions of ligands with phosphorylase b.	1. the interaction of rabbit muscle glycogen phosphorylase b with pairs of ligands has been examined. 2. the electron spin resonance spectrum of a spin label, covalently attached to the protein, provided information about dissociation constants, formation of ternary complexes and both negative and positive interactions between different ligand pairs. 3. amp competes with a series of nucleotides (adp, atp, cmp aand cytosine) but with adenosine a ternary enzyme - amp - adenosine complex can be for ...	1976	173552
[newly detected relationships between antibacterial activity and structure of some chalocones].		1976	130785
the separation and reactivity in vitro of a subpopulation of human lymphocytes which bind histamine. correlation of histamine reactivity with cellular maturation.		1976	132992
the effect of increased brain gaba produced by amino-oxyacetic acid on arousal in rats.	previous work has reported behavioral arousal in the rat to be inversely related to cortical gaba production. therefore the effects of an increase in brain gaba levels, induced by amino-oxyacetic acid, on measures of behavioural arousal such as rearing and ambulation were examined. the increase in gaba was immediately associated with decreased rearing, however the behaviour was later indistinguishable from control values while the levels of brain gaba remained raised. it was suggested that the r ...	1976	134388
effects of exercise training and exhaustion on 45ca uptake by rat skeletal muscle mitochondria and sarcoplasmic reticulum.	mitochondrial and sarcoplasmic reticular 45ca2+ uptake and ca2+-atpase activity were determined in skeletal muscle from exercise trained and non-trained rats at rest or following short-term exhaustive exercise. in trained rats exercised to exhaustion, mitochondrial 45ca2+ uptake was significantly depressed when compared to non-trained rats at rest. ca2+-atpase activity of sarcoplasmic reticulum from trained rats exercised to exhaustion was significantly increased as compared to trained rats at r ...	1976	134437
[synchronous electric activity with inspiration in the vastus lateralis muscle of the anesthesied dog breathing spontaneously].	in the dog, under chloralose or pentobarbitone anesthesia and breathing spontaneously, a muscular electrical activity of low voltage synchronous with respiration was observed in m. vastus lateralis. the mean maximum amplitude of this activity is inversely linked with respiratory rate. when the respiratory frequency is equal or exceeds 25 cycles per minute this activity disappears. such a phenomenon seems to be related to the activity of the respiratory centre.	1976	134813
site of hydrolysis of collagen by hot trichloroacetic acid.	when calfskin collagen is treated with trichloroacetic acid at 90 degrees c, it is hydrolyzed to a mixture of peptides, some of which are quite small. cleavage of collagen by acid seems to occur at bonds between proline (or hydroxyproline) and other amino acids, with only a limited specificity for which amino acid donates its amino group to the susceptible peptide bond.	1976	134865
dynamics of sulfonylurea-induced insulin release from the isolated perfused rat pancreas.	in the isolated perfused rat pancreas various sulfonylurea drugs were tested with a basal glucose level of 1 mg/ml in the perfusion buffer and were found to cause a biphasic insulin response. novocs 476, a new and potent sulfonylurea, and glibenclamide qualitatively differed from tolbutamide, glibornuride, glipizide, and glisoxepide, which were all alike in terms of the relationship between first and second phases of insulin release.	1976	134920
control of synthesis of mrna's for t4 bacteriophage-specific dihydrofolate reductase and deoxycytidylate hydroxymethylase.	a 30 degrees c, functional messengers for dcmp hydroxymethylase first appeared 3 to 6 min postinfection and reached their maximum levels at 12 min. chloramphenicol, added before the phage, reduced the rate of mrna accumulation. when the antibiotic was added 6 min postinfection, mrna levels increased at their normal rate but there was no obvious repression of messenger accumulation. delaying the addition of drug until 8 or 12 min had progressively less effect on the pattern of hydroxymethylase mr ...	1976	135096
[tuberculosis in domestic animals and its relationship with human tuberculosis].		1976	135254
[comparative study on lymphocyte stimulation by pha and bacterial endotoxins, particularly in malignant tumor and allergy patients].	in a group of 37 tumor patients with predominantly advanced disease, lps stimulation (lps of sh. sonnei and sh. flexneri) resulted in a significant increase of the transformation rates caused, most probably, by the high proportion of b cells. on the other hand, allergics (drug allergies) did not differ from controls. it seems possible that b cell stimulation by bacterial endotoxins can be used for the assessment of the reactivity of the organism.	1976	135504
studies of the histochemistry, ultrastructure, motor innervation, and regeneration of mammalian intrafusal muscle fibres.		1976	137430
[diuretic action of calcitonin: demonstration of an inhibiting effect on sodium reabsorption in the ascending limb of henlé's loop].	it was found that calcitonin (porcine) at the dose: 4 i.u. mrc./kg/hr (i.v.), in the rabbit, increased the diuresis and oxmolal excretion, and simultaneously decreased free-water reabsorption and urinary osmolality. the results suggest that calcitonin acts by inhibiting sodium reabsorption in the ascending limb of henl's loop. this hypothesis was confirmed by renal autoradiography study with 22na.	1976	140734
ischemia-induced alterations in myocardial (na+ + k+)-atpase and cardiac glycoside binding.	the effects of ischemia on the canine myocardial (na+ + k+)-atpase complex were examined in terms of alterations in cardiac glycoside binding and enzymatic activity. ability of the myocardial cell to bind tritiated ouabain in vivo was assessed after 1, 2, and 6 h of coronary occlusion followed by 45 min of reperfusion, and correlated with measurements of in vitro (na+ + k+)-atpase activity and in vitro [3h]ouabain binding after similar periods of ischemia. regional blood flow alterations during ...	1976	130383
the cutaneous reactions to kallikrein, prostaglandin and thurfyl nicotinate in chronic urticaria and the effect of polyphloretin phosphate.	the erythema and wealing resulting from the application of thurfyl nicotinate ointment (trafuril) and from the inoculation of kallikrein has been studied in patients with chronic urticaria and normal controls. polyphloretin phosphate (ppp) suppressed the reaction in controls but in patients with urticaria it increased the reactions to trafuril and had little effect on the kallikrein reaction. ppp also suppressed the pge2-induced erythma in normal controls but not in urticaria patients. in a sepa ...	1976	59506
studies on the pathogenesis of enteric infections caused by invasive bacteria.	salmonellae, shigellae and some escherichia coli must invade the intestinal epithelial cell and multiply within the mucosa to cause disease. although the bacterial cell most likely possesses several properties essential to this invasive ability, the nature of the cell envelope complex is at present the only characteristic which has been implicated in this process. while a number of pathophysiological events result from invasion, some of our recent efforts have concerned the site and mechanism of ...	1976	62646
levamisole in advanced human breast cancer.	a clinical trial of levamisole, an orally effective modifier of the immune response, is reported in women with primary inoperable breast cancer (stage iii). after being rendered clinically disease-free by radiotherapy to the breast, supraclavicular area, and axilla, patients were allocated alternately to a control group (no further treatment) and a levamisole-treated group (150 mg orally three times a week on alternate weeks) and were followed-up by physical examination and laboratory tests. in ...	1976	55529
[sensitivity of dysentery bacteria to furazolidone and phthalazol according to the materials of medical epidemiological station of odessa-kishinev railroad].		1976	58090
[role of several functional groups in the biological activity of allergenic preparations].		1976	66777
comparative in vitro studies of cinoxacin, nalidixic acid, and oxolinic acid.	cinoxacin and nalidixic acid were found to be similar in in vitro activity against 138 shigella isolates and somewhat less active than oxolinic acid on a weight basis. cross-resistance developed when 10 shigellae were transferred on increasing amounts of the respective agent contained in mueller-hinton agar. plate dilution studies of the effect of changes in agar ph on the minimum inhibitory concentration revealed that the antibacterial activity increased with decreasing ph. protein binding inve ...	1976	12717
kallikrein inhibitors in rat plasma.	the kallikrein inhibitor contents of human and animal plasma were determined with glandular kallikreins ec 3.4.21.8. one ml of plasma could inactivate 20-700 kallikrein units (ku). rat plasma was the most potent and inactivated 230-700 ku. however, no enzyme capable of inactivating kallikrein could be found in this plasma. two fractions which inhibited hog pancreatic kallikrein, a fraction corresponding to alpha2-macroglobulin and a fraction which was eluted prior to albumin, were separated from ...	1977	14935
purification and characterization of a plasminogen activator secreted by cultured human pancreatic carcinoma cells.	a plasminogen activator secreted by cultured human pancreatic carcinoma (mia paca-2) cells has been purified to apparent homogeneity by procedures including sepharose-l-arginine methyl ester affinity chromatography, sephadex g-200 gel filtration, isoelectric focusing, and sodium dodecyl sulfate gel electrophoresis. the plasminogen activator shares many properties with urokinase including: molecular weight (55 000), isoelectric point (8.7), heat stability (60 degrees c, 30 min), ph stability (1.5 ...	1977	15590
acute bacteremia in asplenic renal transplant patients.	four cases of overwhelming bacteremia were observed in asplenic renal transplant patients 12 to 20 months after transplantation. the bacteriologic findings and presentation of these infections are characteristic of post-splenectomy sepsis reported in nontransplant patients. it is suggested that the absence of the spleen, more than immunosuppression with azathioprine and prednisone, predisposes to these late, uncommon infections after transplantation.	1977	16144
identification of essential histidine residues of aminoacylase by photooxidation and by reaction with diethylpyrocarbonate.	state and function of the histidine residues of aminoacylase were investigated by photoxidation in the presence of methylene blue and by chemical modification with diethylpyrocarbonate. complete inactivation of the enzyme was observed after oxidation of 4 histidine residues. from the ph dependence of the photooxidation it becomes evident that the inactivation of the enzyme is not a consequence of the simultaneous oxidation of tryptophan residues. the enzyme is also inactivated by chemical modifi ...	1977	17959
detection of salmonella antigens in the neutralization reaction (anr).		1977	17975
effect of oligomycin on coupling in isolated mitochondria from oligomycin-resistant mutants of saccharomyces cerevisiae carrying an oligomycin-resistant atp phosphohydrolase.		1977	20055
role of phospholipids in muscarinic binding by neural membranes.		1977	20109
drug effects on blood pressure and heart rate in unanesthetized animals. (1). effects of beta-blocking agents (author's transl).	beta-blocking actions of orally administered kö 1400 and tiprenolol, new beta-blocking agents, were studied in unanesthetized rats and dogs, using a fall of blood pressure and an increase in heart rate produced by isoproterenol as a measure of beta-receptor activation. blood pressure was recorded from the aorta of the dog and the caudal artery of rat via indwelling catheter, and heart rate of the dog was recorded by a cardiotachometer triggered by r waves of the lead ii electrocardiogram. mean r ...	1977	20392
liver enzyme adaptation after lithium administration in handled and nonhandled rats.	we have examined the interaction of lithium administration and the infant stimulation procedure of handling on hormonally regulated enzymes of liver. animals handled in infancy show an increased morning corticosterone level in response to lithium feeding and markedly elevated serum glucose during refeeding following a two day fast, when compared to non-handled control animals. lithium alters serum corticosterone both in response to the stress of fasting, and during the diurnal cycle following gl ...	1977	21840
[study of genetic control of synthesis of type iii and 6th group-specific antigens of flexner shigellae].	as revealed in experiments of interspecific and intraspecific crosses, the determinant responsible for the group-specific 6, as well as controling the synthesis of type iii antigens of sh. flexneri were localized near the lac-pro markers on the chromosome. in intraspecies crosses of bacteria of y variant with the donor sh. flexneri 3c strain the percentage of linking of lac+a6+ was 32, and of lac+aiii+ --24. genetic confirmation of the dependence of the function of the a6 (defined as att6) deter ...	1977	68643
study on the ion-permeability of human dental enamel with special reference to an electrochemical approach.		1977	34011
[several allergic reactions under conditions of functioning of an inhibitor of antibody activity in the body].	allergization under conditions of functioning an inhibitory factor in the organism was studied by the reaction of leukocytolysis with tsuverkalov's dysenterin and in the reproduction of hypersensitivity of the immediate type on the schultz-dale's model. it was shown that in functioning an inhibitory factor in the organism the degree of leukocytolysis reaction with the dysentery allergen decreased in the immunized animals in parallel with the fall in the serum antibody activity. a depression of t ...	1977	65882
alertness, level of activity, and purposive movement following somatosensory deafferentation in monkeys.		1977	96722
immunization with dextransucrases, levansucrases, and glycosidic hydrolases from oral streptococci. ii. immunization with glucosyltransferases, fructosyltransferases, and glycosidic hydrolases from oral streptococci in monkeys.	the feasibility of immunizing monkeys with enzymes from oral streptococci in an attempt to reduce dental caries was investigated. forty rhesus monkeys, macaca mulatta, were used. cariogenic streptococci, s mutans, were implanted into all the monkeys' mouths. there was no pathological effect resulting from immunization. of the 40 animals, 30 retained the implanted flora throughout the experiment; the remaining 10 were reimplanted until the streptococci remained. in six months, gross carious lesio ...	1977	98540
tropical diseases.		1977	97727
placental permeability in the sheep.	the transplacental flux of different radiolabelled substances was measured, according to fick's principle, in chronically catheterised pregnant sheep (124 to 143 days of gestation). knowing the uterine blood flow, it was possible to calculate the net flux and derive a permeability coefficient, k. with 14c erythritol, k soon reaches its ultimate value, thus suggesting there is only one rate-limiting step to transfer and no significant middle compartment in the sheep placenta. the comparison of fe ...	1977	98093
[food additives and their possible genetic toxicity; microbiological determination].	in the present work we intend to find an accurat methodology to establish in an easy way the mutagenic potential of drugs employed as food additives. for that purpose we first selected a microbiological system for performing this assay. the method assayed consisted of investigating the effect exerted on genetic recombination by the following chemical agents: chloroacetic acid, iodoacetic acid, sorbic acid, potassium metabisulfite, sodium nitrite, auramine and erythrossine. the activity of these ...	1977	98122
a study on the relationship dose-effect in case of gamma-irradiation on leptospira.		1977	98416
[therapeutic results in an epidemic outbreak of dysentery].	the therapeutical results obtained in an epidemical outbreak of dysentery caused by shigella flexneri type 2 a are reported, emphasizing the bacteriological failure of the treatment with furazolidin in 52.1% of the cases and the good results obtained with neomycin (mycerine).	1977	141082
a reconstituted na+ + k+ pump in liposomes containing purified (na+ + k+)-atpase from kidney medulla.	liposomes containing either purified or microsomal (na+,k+)-atpase preparations from lamb kidney medulla catalyzed atp-dependent transport of na+ and k+ with a ratio of approximately 3na+ to 2k+, which was inhibited by ouabain. similar results were obtained with liposomes containing a partially purified (na+,k+)-atpase from cardiac muscle. this contrasts with an earlier report by goldin and tong (j. biol. chem. 249, 5907-5915, 1974), in which liposomes containing purified dog kidney (na+,k+)-atp ...	1977	141941
ligand-dependent tryptic inactivation of the ouabain sensitivity of adp-atp exchange catalyzed by canine renal na+, k+-atpase.		1977	143280
[a case of bacteremia caused by shigella flexneri].		1977	143707
cardiac hypertrophy and antihypertensive therapy.	biochemical (myocardial dna, rna, and hydroxyproline) and humoral (plasma [pra] and kidney [kra] renin activity) factors were determined in spontaneously hypertensive rats (shr) and normotensive wistar controls (nr) before and following treatment with minoxidil or propranolol. minoxidil (150 mg.litre-1 drinking water) effectively controlled blood pressure (17.3 kpa vs 24.9 kpa [130 mmhg vs 187 mmhg], p less than 0.001) despite marked and sustained increases in both pra and kra ventricular weight ...	1977	145319
inhibition of herpesvirus saimiri replication by phosphonoacetic acid, benzo(a)pyrene, and methylcholanthrene.	the present investigations were undertaken to determine the possible effects of two carcinogenic polycyclic aromatic hydrocarbons, benzo(a)pyrene and 3-methylcholanthrene on herpesvirus saimiri replication. the results from these experiments were compared with the effects of phosphonoacetic acid on the virus replication cycle. phosphonoacetic acid inhibited the synthesis of virus-induced intracellular late antigens, membrane antigens and infectious virus but not the synthesis of the early antige ...	1977	187336
cell surface markers on epithelial-burkitt hybrid cells superinfected with epstein-barr virus.	attempts were made to superinfect two epithelial-burkitt hybrid cell lines, designated d98/hr-1 and d98/raji, with epstein-barr virus (ebv) and to investigate the expression of some cell surfacr markers including histocompatibility antigens, and the presence of b-cell markers, such as receptors for the third complement component and for monkey red blood cells. successful superinfection of d98/hr-1 cells with ebv was made evident by the expression of early antigen and, to a lesser extent, virus c ...	1977	193641
purification and subunit composition of guanosine 3':5'-monophosphate-dependent protein kinase from bovine lung.	the guanosine 3':5'-monophosphate-dependent protein kinase from bovine lung was purified to apparent homogeneity by affinity chromography using 8-2-aminoethylthio-cgmp coupled to sepharose 4b. the kinase activity was purified approximately 6000-fold with an overall recovery of approximately 20%. the product isolated by affinity chromatography contained both cgmp-binding and cgmp-dependent histone kinase activity, indicating that the enzyme was not dissociated into regulatory and catalytic compon ...	1977	193862
alterations of acetylcholine enzymes in neuroblastoma cells persistently infected with lymphocytic choriomeningitis virus.		1977	193868
[early stages of the infectious process].		1977	194438