Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [the national symposium on the digestive diseases treated by traditional chinese medicine combined with western medicine]. | 1992 | 1358294 | |
| structural comparison of urease and a groel analog from helicobacter pylori. | electron microscopy of purified protein preparations indicated that helicobacter pylori urease consisted of circular particles that are 13 nm in diameter, some of which showed indications of threefold rotational symmetry. a groel analog of h. pylori (hp60k) appeared as a disc-shaped molecule with a diameter similar to that of urease but possessed sevenfold rotational symmetry. in a side-view projection, hp60k appeared as two or four discs stacked side by side. | 1992 | 1358875 |
| serological assessment of helicobacter pylori eradication. | 1992 | 1359233 | |
| isolation of helicobacter pylori from human faeces. | helicobacter pylori is arguably the commonest chronic infection in man. however, its route of transmission is unknown. we have isolated viable h pylori from the faeces of an infected individual from the gambia. the organism was cultured on selective media after concentration of faecal bacteria by centrifugation in a buffer equilibrated with a microaerophilic gas mixture. growth characteristics, microscopic appearances, and enzyme activities were the same as those of a typical gastric isolate of ... | 1992 | 1359263 |
| [drug therapy of peptic ulcer in the elderly]. | medical therapy of peptic ulcers in elderly patients should depend on drugs which have to be administered only once daily. in addition, the ideal compound should have minimal side effects as well as minimal, if any, interactions with concomitant forms of therapy. from this point of view, acid-inhibitory drugs are preferable to other anti-ulcer drugs, the latter having little importance in advanced age. for ulcer healing, the proton pump inhibitor omeprazole is recommended, whereas h2-blockers (p ... | 1992 | 1359717 |
| studies on antiulcer drugs. vi. 4-furyl-2-guanidinothiazoles and related compounds as potent histamine h2-receptor antagonists. | a series of 4-furyl-2-guanidinothiazole derivatives and related compounds were synthesized and evaluated for histamine h2-receptor antagonist and gastric acid antisecretory activities. among them, compounds i-17, i-48 and i-49 showed high activities in these tests. in addition, compound i-17 possessed potent inhibitory activities on each of the gastric ulcers induced by stress, ethanol and hcl-aspirin. on the other hand, compound i-48 demonstrated antimicrobial activity against helicobacter pylo ... | 1992 | 1359931 |
| helicobacter pylori and peptic ulcers in rheumatoid arthritis patients receiving gold, sulfasalazine, and nonsteroidal anti-inflammatory drugs. | the conflicting reports on gold and helicobacter pylori could be related to the use of serological tests of unproven value in nsaid patients, and to the lack of the appropriate control groups. more important is the fact that the endoscopic consequences of the possible effect of gold on h. pylori have not been investigated. we therefore decided to assess the prevalence of h. pylori and peptic ulcers in rheumatoid patients being treated with gold sodium thiomalate (gst) plus nsaid, sulfasalazine p ... | 1992 | 1360191 |
| pcr-based rflp analysis of dna sequence diversity in the gastric pathogen helicobacter pylori. | dna sequence diversity among 60 independent isolates of the gastric pathogen helicobacter pylori was assessed by testing for restriction fragment length polymorphisms (rflps) in several pcr-amplified gene segments. 18 mbol and 27 haeiii rflps were found in the 2.4 kb urea-ureb (urease) segment from the 60 strains; this identified 44 separate groups, with each group containing one to four isolates. with one exception, each isolate not distinguished from the others by rflps in urea-ureb was distin ... | 1992 | 1361982 |
| bacterial flagellar diversity and significance in pathogenesis. | bacterial flagella are structurally diverse, ranging from the thoroughly investigated model examples found in escherichia coli and salmonella typhimurium to the more exotic sheathed flagella of, for example, helicobacter pylori, and the complex multi-flagellin endoflagella found in many spirochaetes. we summarize some of the emerging structural and genetic findings relating to these more novel flagellar types, and outline their possible significance in the pathogenicity of some medically importa ... | 1992 | 1362173 |
| modern management of peptic ulcer. | 1992 | 1363332 | |
| [current alteration of helicobacter pylori in gastro-duodenal diseases]. | the current alteration of the detection rate of helicobacter pylori (h. pylori) on mucous membranes of the stomach has been surveyed and reviewed for 49 cases of gastro-duodenal diseases. the survey has been conducted for 3 years and an endoscopic examinations have been performed 2-8 times. on the first visit, the diagnosis can be made endoscopically, and h2 blockers and another agents were used as therapeutic drugs. the detection rate was 67.3% (33 cases) for positive cases and positive reactio ... | 1992 | 1363434 |
| the success of histamine-2 receptor antagonists. | the lives of both patients and doctors have been revolutionized since the development of histamine-2 receptor antagonists. their development has introduced, for the first time, a rapid, reliable, and save means of healing both duodenal and gastric ulceration. the continuous administration of these agents has additionally been shown to reduce ulcer relapse and subsequent complications. in addition, they offer some protection from the development of nonsteroidal anti-inflammatory drug-induced dama ... | 1992 | 1363678 |
| resistance to medical ulcer therapy--possible reasons and management. | in 112 patients with duodenal ulcer (males, mean age 29, range 18-35) with a history of at least 3 years, and never being treated with h2-antagonists, maintenance therapy with tagamet was started. all of them had ulcer recurrence when entering the study. the first two months a full dose was applied, after this bedtime doses up to 24 months. endoscopy was performed at the beginning, after the first and second months and then every two-month period. gastric secretion was measured every 2-3 months. ... | 1992 | 1364278 |
| duodenal ulcer disease: to treat h. pylori infection or not? | 1992 | 10147111 | |
| helicobacter pylori before and after gastric reduction for morbid obesity. | nine patients with morbid obesity were evaluated for the presence of helicobacter pylon (hp) before gastric reduction, and all were negative. fifteen patients, including those nine, were evaluated for the presence of hp in antral and 'channel' region biopsies by culture and urease test after gastric reduction. hp-negative patients totaled 73.3% by both tests, although chronic superficial gastritis type 'b' was found in eight out of 13 (61.5%), and six out of seven (85.7%) gastritis patients were ... | 1992 | 10765199 |
| [brief history of laboratory technique on the examination of helicobacter pylori] (chi). | 1992 | 11612990 | |
| association of helicobacter pylori and nonulcer dyspepsia. | the etiology and pathogenesis of nonulcer dyspepsia (nud) are not completely understood and consequently, no specific medication can be prescribed to the sufferers. we studied 69 cases, proved clinically, laboratorally, sonographically and endoscopically, to have nud. antral biopsy was taken from every case and subjected to clo test. out of the 69 patients, 51 (74%) were infected with helicobacter pylori (hp). oral medication, consisting of amoxacillin 500 mg, metronidazol 500 mg, and bismuth mi ... | 1992 | 17589136 |
| neurotoxic effects of bismuth in vitro. | although insoluble bismuth (bi) salts are known to be neurotoxic, recently interest in oral bi therapy has been renewed because of encouraging results obtained in the treatment of gastritis and peptic ulcer associated with helicobacter pylori infection. for risk assessment of orally administered bi preparations it is important to determine the minimal neurotoxic bi concentration in the brain. this concentration was determined in cultures of brain, meninges and neuronal retina cells from embryoni ... | 1992 | 20732125 |
| omeprazole: a pharmacoeconomic evaluation of its use in duodenal ulcer and reflux oesophagitis. | omeprazole regulates gastric acid secretion and is an effective treatment of acute duodenal ulcer and reflux oesophagitis, achieving more rapid healing and symptomatic relief than histamine h 2-receptor antagonists. when administered as maintenance therapy, omeprazole reduces the incidence of relapse. the drug is also highly effective in patients poorly responsive to histamine h 2-receptor antagonists. the daily acquisition cost of omeprazole is higher than that of histamine h 2-receptor anta ... | 1993 | 10146883 |
| [the pathogenic role of helicobacter pylori]. | the urease test and bacterioscopy of impression smears were used to detect helicobacter pylori (hp) in biopsies from pyloric gastric mucosa of 77 (89.5%) of 86 chronic gastritis patients, of 27 (4%) from 32 duodenal ulcer patients, of 84 (84.0%) from 100 healthy male subjects aged 18-20. there was focal hyperemia in pyloric part of the stomach in 59 patients, leukocytic infiltration of mucous membrane was found histologically in 78 ones. close correlation between complaints, endoscopic and histo ... | 1993 | 9132998 |
| [the efficacy of different types of laser irradiation in patients with long-term nonhealing duodenal ulcers]. | the results are available on 114 patients treatment with laser irradiation. all the patients had indolent duodenal ulcer, received irradiation of various types. the best short- and long-term response has been achieved with high-intensity impulse laser regimens. in addition of hyperbaric oxygenation and local introduction of granulocyte concentrate to the above radiation, the effectiveness of the treatment was still higher, while the relapses arose two times less frequently. | 1993 | 9133003 |
| [the factors determining the course and outcome of chronic duodenitis in adolescents and young people]. | causes involved in progression of duodenal lesions have been analyzed in 55 adolescents with chronic duodenitis. five-year follow-up revealed factors with potential influence on the outcome: sex, acid-peptic factor, mucosal contamination with helicobacter pylori, an initial morphological form of duodenitis. the latter developed into peptic ulcer in 15% of the male patients. progression of duodenitis was associated with emergence of chronic gastritis. motor biliary function deteriorated in 39% of ... | 1993 | 9133005 |
| inhibition of gastric mucosal mucin receptor by helicobacter pylori lipopolysaccharide. | a gastric mucosal mucin receptor has been isolated from the epithelial cell membrane by affinity chromatography on wheat germ agglutinin. the receptor protein displayed an apparent molecular weight of 97kda and exhibited binding specific to gastric mucin in a concentration-dependent manner. the binding of mucin to the mucosal receptor was inhibited by lipopolysaccharide from h. pylori. the inhibitory effect was proportional to the concentration of lipopolysaccharide up to 30 micrograms/ml, at wh ... | 1993 | 7514919 |
| isolation and characterization of "flexispira rappini" from laboratory mice. | a bacterium with an unusual ultrastructure and possessing a fusiform protoplasmic cylinder, spiral periplasmic fibers, and bipolar tufts of sheathed flagella was identified in the intestinal mucosae of laboratory mice. the organism was cultured under microaerophilic conditions and was found to rapidly hydrolyze urea. on the basis of 16s rrna gene sequence analysis, the organism was shown to be "flexispira rappini." "f. rappini" is closely related to members of the genus helicobacter and has been ... | 1993 | 7504685 |
| immunological specificity of helicobacter pylori urease and identification by immunological detection of its specific urease. | helicobacter pylori urease was recovered as a single peak by deae-sepharose column chromatography and sephacryl s-200 gel filtration. the purified urease was obtained by fast protein liquid chromatography using a mono q column. the purified urease preparation gave a single band in polyacrylamide gel disc electrophoresis. latex particles were sensitized with anti-urease immunoglobulin. the sensitized latex particles were agglutinated with the purified urease and by cell sonicates obtained from 55 ... | 1993 | 7505793 |
| isolation of a sialic acid-specific surface haemagglutinin of helicobacter pylori strain nctc 11637. | a deionized water extract of helicobacter pylori nctc 11637 contained haemagglutinin activity that was (i) soluble (i.e., not associated with particulate material sedimented by centrifugation at 100,000 x g for 1 h), (ii) stable to lyophilization, (iii) heat-labile, (iv) chymotrypsin-sensitive, (v) inhibited by fetuin, orosomucoid, and nanlac, but not by asialofetuin and (vi) inactive against guinea pig erythrocytes incubated with clostridium perfringens neuraminidase, but active against untreat ... | 1993 | 7506596 |
| [anti-hp antibody may vary with strain used as antigen possibly due to serological diversity]. | western blotting and elisa techniques have been used to investigate antigen specificity of systemic responses. immunoblotting studies demonstrate several major protein antigens that are detected most sera. h. pylori immunoblotting studies using rabbit hyperimmune sera identify several distinct strains. seven monoclonal antibodies which are prepared in our laboratory recognize 33-35 kda and 66 kda of h. pylori. elisa studies using the monoclonal antibody reveals considerable antigenic diversity a ... | 1993 | 7506798 |
| [digestion of human gastric mucous by extracellular helicobacter pylori enzyme]. | helicobacter pylori (hp) is a causative pathogen of chronic gastritis and strongly associated with recurrence of duodenal ulcers, but the mechanism is not known. we studied the possible digestion of gastric mucus by hp extracellular enzyme in human stomach. hp was isolated from biopsy specimens taken from peptic ulcer patients or normal individuals and its extracellular enzyme was collected. incubation of human gastric mucosa with hp extracellular enzyme resulted in a significant decrease of pas ... | 1993 | 7506799 |
| helicobacter pylori: a comparison of clo test and giemsa's stain with culture in dyspeptic patients. | the prevalence of h.pylori in thailand is high compared with western countries and is the same as in china. we suggest either rapid urease test (clo test) or giemsa stain to be a rapid, reliable and convenient detection method for h.pylori and is also suitable for use in follow-up studies by gastroenterologists. | 1993 | 7509357 |
| [comparative evaluation of some morphologic methods for detecting helicobacter pylori in gastric mucosa]. | gastroscopic examination was performed in 183 patients with upper gastrointestinal symptoms, with brush biopsy and taking of mucosa specimens for cytological and histopathological examination in order to detect the presence of helicobacter pylori. greater effectiveness of brush biopsy was demonstrated in comparison to histological examination of tissue fragments and significantly higher effectiveness of staining using the giemsa-may-grunwald method was shown in comparison to staining with hemato ... | 1993 | 7526557 |
| cloning, nucleotide sequence, and expression of a gene encoding an adhesin subunit protein of helicobacter pylori. | gene hpaa, which codes for the receptor-binding subunit of the n-acetylneuraminyllactose-binding fibrillar hemagglutinin (nlbh) of helicobacter pylori, was cloned and sequenced. the protein expressed by hpaa, designated hpaa, was identified as the adhesin subunit on the basis of its fetuin-binding activity and its reactivity with a polyclonal, monospecific rabbit serum prepared against nlbh purified from h. pylori. sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis and western bl ... | 1993 | 7678592 |
| serum 13c-bicarbonate in the assessment of gastric helicobacter pylori urease activity. | noninvasive detection of helicobacter pylori (hp) requires serum or salivary antibody testing or the co2 breath test. since gastric hp produces a potent urease, a meal rich in 13c-labeled urea should lead to a measurable quantity of isotopic co2 in the serum. this study investigates the feasibility, sensitivity, specificity, and potential of the measurement of serum 13c-bicarbonate (13chco3) in determining the presence of gastric hp. nineteen patients with upper gastrointestinal symptoms assesse ... | 1993 | 7679876 |
| structural analysis and demonstration of the 29 kda antigen of pathogenic entamoeba histolytica as the major accessible free thiol-containing surface protein. | the 29 kda protein of pathogenic entamoeba histolytica is a cysteine-rich surface antigen which we recently characterized by cdna sequencing and by using monoclonal antibodies which differentiated between pathogenic and non-pathogenic clinical isolates. to determine the structure and biochemical attributes of this protein, a repertoire of immunological techniques using monoclonal antibodies, and radiolabelling were employed. we demonstrated that the 29 kda protein forms a 60 kda dimer and a high ... | 1993 | 7682280 |
| affinity of the gastric pathogen helicobacter pylori for the n-sulphated glycosaminoglycan heparan sulphate. | binding of 125i-heparan sulphate was a common property of helicobacter pylori strains isolated from patients with gastroduodenal ulcer diseases. binding was (i) saturable; (ii) reversible by the addition of unlabelled heparan sulphate and heparin; (iii) inhibited by unlabelled heparan sulphate, heparin, and heparin oligosaccharides but not by other glycosaminoglycans of comparable size (chondroitin sulphate and dermatan sulphate) or by highly glycosylated glycoproteins (hog gastric mucin and fet ... | 1993 | 7682621 |
| helicobacter pylori detection: a quality and cost analysis. | histopathologic interpretation of hematoxylin and eosin (h&e)-stained endoscopic biopsies is a common method for identifying helicobacter pylori. few studies report the accuracy of this method, and none have compared costs of other diagnostic methods. in the clinical setting of a community hospital using standard diagnostic techniques, the purpose of this study were to determine 1) the comparative sensitivities and specificities of the h&e stain, the warthin-starry silver stain, the giemsa stain ... | 1993 | 7683175 |
| helicobacter pylori potentiates histamine release from serosal rat mast cells in vitro. | helicobacter pylori seems to be involved in the etiology of peptic ulcer and chronic gastritis. histamine is fundamental in gastric secretion modulation, and some features of h. pylori-associated gastritis (edema, vasodilatation, inflammatory cell infiltration) are typical of the histamine-mediated response. this in vitro study has been undertaken as a preliminary step, in order to find a possible link between h. pylori and histamine release. h. pylori isolated from gastric biopsies has been tes ... | 1993 | 7683264 |
| partial characterization of an external polysaccharide of helicobacter pylori by using an immunoglobulin m monoclonal antibody. | a monoclonal immunoglobulin m antibody, hp15/36, was produced by a hybridoma cell line prepared by fusion of mouse myeloma cell line sp2/o with spleen cells of mice immunized with helicobacter pylori d273 (french strain). immunoelectron microscopy of whole bacteria and ultrathin sections showed that the determinant was located outside the bacterial cell, possibly in the outermost areas. this external reactivity was observed by immunofluorescence and immunoperoxidase assays and was confirmed by i ... | 1993 | 7684730 |
| helicobacter pylori in gastric biopsies--should you trust the pathology report? | the presence of helicobacter pylori in gastric biopsies is closely associated with gastritis and duodenal ulceration. we have assessed the reliability of h pylori identification on haematoxylin and eosin (h & e) stained sections of gastric biopsies showing gastritis. a set of 20 slides was shown to 20 histopathologists (a total of 400 diagnoses); 11 of them were h pylori-positive, assessed using two special stains. participants were asked to comment on the presence or absence of h pylori on h & ... | 1993 | 7684784 |
| characteristics of helicobacter pylori alcohol dehydrogenase. | helicobacter pylori shows alcohol dehydrogenase activity, which in the presence of ethanol leads to in vitro production of acetaldehyde, a toxic and highly reactive substance. the present study was undertaken to further define h. pylori-related ethanol and acetaldehyde metabolism by characterizing h. pylori alcohol dehydrogenase and by determining whether the organism possesses aldehyde dehydrogenase. | 1993 | 7687573 |
| detection of helicobacter pylori by papanicolaou-stained touch imprint: a comparison with histologic examination. | 1993 | 7687822 | |
| a review of diagnostic techniques for helicobacter pylori infection. | the description of helicobacter pylori and an understanding of its pathogenetic significance has been one of the major breakthroughs in gastroenterology in the past decade. because of the possible implications, a correct diagnosis of the infection is mandatory. diagnostic techniques can be divided into invasive and non-invasive methods. the first require upper gastrointestinal endoscopy with a biopsy taken from the stomach. these biopsy specimens can be studied for the presence of h. pylori usin ... | 1993 | 7690313 |
| functional dyspepsia. current treatment recommendations. | symptoms of functional dyspepsia are frequent; the prevalence of dyspepsia (defined as pain or discomfort centred in the upper abdomen) in the general population approaches 25%. by definition, patients with functional dyspepsia do not have a structural or biochemical explanation for their symptoms. disorders of function (e.g. delayed gastric emptying) are detectable in a proportion of patients but remain poorly understood. nevertheless, the current rationale for drug treatment is based on alteri ... | 1993 | 7691499 |
| adhesion of helicobacter pylori to gastric epithelial cells in primary cultures obtained from stomachs of various animals. | of 35 strains of helicobacter pylori tested, 5 were found to adhere well to hep-2 cells. we selected three of these adhesive strains and four from the remaining strains to examine their ability to adhere to gastric epithelial cells in primary cultures obtained by collagenase digestion of stomachs from mice, rats, mongolian gerbils, guinea pigs, pigs, and cynomolgus monkeys. the three adhesive strains adhered well to epithelial cells from monkey and pig gastric antra. the adhesion was inhibited b ... | 1993 | 7691743 |
| serological testing for campylobacteriosis with sera forwarded for salmonella and yersinia serology. | single serum specimens forwarded for salmonella and yersinia serology, from a total of 250 patients, were tested for anti-c. jejuni antibodies of the igg class. anti-salmonella and anti-y. enterocolitica o3 antibodies were examined by a microagglutination test and anti-c. jejuni antibodies by elisa against a c. jejuni ultrasonicate before (elisa) and after neutralization of antibodies which cross-reacted with helicobacter pylori antigens (elisa-abs). blood donor sera (n = 50) and sera (n = 40) f ... | 1993 | 7692894 |
| microbiological aspects of helicobacter pylori infection. | helicobacter pylori colonises the human gastroduodenal mucosa, causes chronic active gastritis, is a co-factor for the development of duodenal ulceration, and is associated with gastric ulceration and gastric cancer. as there are no readily available typing schemes for identification of individual isolates, little is known about the acquisition, distribution and frequency of particular strains of h. pylori in different populations, communities and families. molecular (dna) typing studies carried ... | 1993 | 7693149 |
| the epidemiology of helicobacter pylori: missing pieces in a jigsaw. | gastric colonisation with helicobacter pylori is common throughout the world. although most infected individuals remain well, h. pylori is involved in the pathogenesis of type b gastritis and peptic ulcer disease. there is also an epidemiological association with gastric cancer. person-to-person spread is the most likely form of transmission but it is not clear whether this is faecal-oral or oral-oral. the risk factors for developing disease following infection are poorly understood. the develop ... | 1993 | 7693150 |
| clinical aspects of infection with helicobacter pylori. | about 90% of patients with duodenal ulcer and 65% of those with gastric ulcer are infected with helicobacter pylori. h. pylori infection can be diagnosed by examination of biopsy material obtained at endoscopy; by 14c or 13c-urea breath tests, or by serological means. the relapse rate of duodenal and gastric ulcers can be considerably reduced if the bacteria are eradicated. some of the current treatment regimens are discussed. | 1993 | 7693151 |
| can eradication of helicobacter pylori prevent gastric cancer? gastrointestinal physiology working group of cayetano heredia. | 1993 | 7693426 | |
| rapid detection and characterization of sialic acid-specific lectins of helicobacter pylori. | a particle agglutination assay (paa) using fetuin (ft) covalently coupled to carboxylate-modified latex (cml) particles was evaluated for rapid detection of sialic acid-specific haemagglutinins/lectins (sals) of helicobacter pylori isolates which bind sialoglycoconjugates. sixty-three percent (20/32) of the isolates examined gave a positive paa test. cell-bound sals were extracted by washing the bacteria with deionized water or isotonic saline, and their expression was influenced by ph and cultu ... | 1993 | 7694599 |
| campylobacter showae sp. nov., isolated from the human oral cavity. | nine campylobacter-like strains were isolated from human gingival crevices and characterized. these strains were gram-negative, straight rods that were motile by means of multiple unipolar flagella. they were asaccharolytic and preferred an anaerobic atmosphere rather than a microaerophilic atmosphere for growth, and their growth was stimulated by formate and fumarate. these strains were biochemically similar to campylobacter curvus and campylobacter rectus, but were clearly distinguishable from ... | 1993 | 7694633 |
| [diagnostic methods in helicobacter pylori infection]. | since their description by marshall and warren now ten years ago, a lot of tests have emerging in order to detect infection by helicobacter pylori. these tests are analyzed in this paper. we divided them in invasive, because they need an endoscopy with biopsy and non invasive with no endoscopy. we inform about the sensitivity and specificity of each one. from the invasive test the histology could be a good alternative for the diagnosis. in order to do epidemiological studies serology is good, an ... | 1993 | 7747032 |
| helicobacter pylori and intestinal metaplasia in antral mucosa. a study on their correlation. | to investigate the possible relation between helicobacter pylori (hp) colonization and incidence of intestinal metaplasia (im), antral biopsy specimens from a total of 263 subjects (167 had chronic gastritis, 12 gastric cancer, and 84 no histological changes) were examined. im was observed in 27.7% of the hp positive specimens and in 18.3% of the hp negative biopsies (p = ns). histochemical characterization of mucins showed that the percentage of hp colonization was not significantly different w ... | 1993 | 7761658 |
| [does no helicobacter pylori mean no duodenal ulcer?]. | 1993 | 7779166 | |
| management of peptic ulcer. | 1993 | 7784326 | |
| [detection of helicobacter pylori by the urease test in 244 patients]. | the authors report the results of the detection of helicobacter pylori (hp) in gastric mucosa by the urease test, in 244 patients between january 1989 and august 1991. the overall prevalence of hp was 38.1%. it was 19.5% in patients with normal upper gastrointestinal endoscopy (ue), 61% in duodenal ulcer (p < 0.001) and 68.7% in congestive antritis (p < 0.001), significantly higher than in controls. there was no significant difference between controls and patients with erosive antritis or healed ... | 1993 | 7799411 |
| [helicobacter pylori in patients with diseases of the upper part of the gastrointestinal tract]. | among the patients subjected to esophoagogastroduodenoscopy because of different clinical indications, 108 were examined for the presence of helicobacter pylori in the antral gastric mucosa. microbiological analysis of the antral gastric mucosa biopsies were conducted by direct microscopy, the urease test and by growing in nutritious media. positive findings were recorded in 38 (86.36%) patients with endoscopically diagnosed chronic gastritis, 29 (80.56%) patients with duodenal ulcer and 19 (67. ... | 1993 | 7862044 |
| campylobacter meets helicobacter: the joint meeting. brussels, september 21-25, 1993. abstracts. | 1993 | 7914389 | |
| local and systemic immune response in helicobacter pylori-associated chronic gastritis before and after treatment. | ten patients with helicobacter pylori-associated chronic gastritis were given combination therapy for 6 weeks with a bismuth subnitrate-containing compound and bacampicillin. the eradication rate was 40% 6 weeks after the end of treatment. two patients remained h. pylori-negative at long-term follow-up after 6 and 17 months; that is, h. pylori was only eradicated in 20% of the patients after long-term observation. by dot blot and immunoblotting both urease and an urease-associated heat shock pro ... | 1993 | 7905661 |
| mechanisms involved in helicobacter pylori-induced inflammation. | helicobacter pylori infection is associated with mucosal inflammation. the aims of the present study were to assess whether a water extract of h. pylori promotes neutrophil (polymorphonuclear leukocyte [pmn]) adherence to endothelial cells and define the molecular basis of this adhesive interaction. | 1993 | 7901109 |
| transmission of helicobacter pylori via faeces. | 1993 | 7901696 | |
| [controversies and trends in ulcer therapy. 2: prevention of recurrence]. | 1993 | 7901948 | |
| helicobacter pylori causes hyperproliferation of the gastric epithelium: pre- and post-eradication indices of proliferating cell nuclear antigen. | to assess the effect of helicobacter pylori (hp) eradication on the proliferation of the gastric epithelium by the expression of the proliferating cell nuclear antigen (pcna). | 1993 | 7901989 |
| effect of helicobacter pylori eradication on antral gastrin- and somatostatin-immunoreactive cell density and gastrin and somatostatin concentrations. | the density of antral gastrin (g)- and somatostatin (d)-immunoreactive cells and the contents of antral gastrin and somatostatin were investigated in endoscopic antral biopsy specimens from patients with duodenal ulcer before and after eradication of helicobacter pylori. after h. pylori eradication both antral somatostatin concentration (p = 0.0002) and antral d-cell density (p = 0.01) increased significantly. conversely, although the number of g-cells was unchanged, antral (p = 0.0002) and seru ... | 1993 | 7903471 |
| [restriction endonuclease (noti) analysis of chromosomal dna of helicobacter pylori by pfge]. | with the goal of differentiating h. pylori in order to clarify its pathogenicity, we have conducted a restriction endonuclease of the chromosomal dna of 24 strains of h. pylori employing the restriction endonucleases, noti, cpoi, kpni, and smai using pulsed-field gel electrophoresis (pfge). with noti, these 16 strains out of 24 strains were completely digested, and 16 clearly different electrophoretic patterns of noti digested chromosomal dna fragments were seen, permitting us to successfully di ... | 1993 | 7904319 |
| [polymorphism of helicobacter pylori urease genes and gastric diseases]. | helicobacter pylori (hp) is now recognized as a major etiologic agent of chronic gastritis and peptic ulcer and is recently presumed to be a cofactor in the occurrence of gastric cancer. hp has a high urease activity, which possibly plays a role in the pathogenesis of gastroduodenal diseases. in this paper, the function and the genetic structure of hp urease gene and the restriction fragment length polymorphism (rflp) among hp strains using a probe of hp urease alpha subunit gene were described. ... | 1993 | 7904320 |
| [the role of eradication of helicobacter pylori in healing and recurrence of gastric ulcer]. | it is now generally accepted that infection with helicobacter pylori is the most common cause of active chronic gastritis and duodenal ulceration. although h. pylori is detected in the majority of patients with gastric ulcer, its pathogenicity and role in gastric ulceration remains unclear. one method to study this relationship is to eradicate h. pylori and observe the recurrence of gastric ulcer. in the present paper we examined the consequence of h. pylori eradication by antibiotics mono thera ... | 1993 | 7904321 |
| serum levels of pepsinogen i in healthy volunteers and patients with gastric ulcers and gastric carcinoma in taiwan. | in order to investigate the clinical usefulness of human pepsinogen i (pgi) as a noninvasive diagnostic tool for gastric lesions, 92 healthy volunteers, 87 patients with a gastric ulcer and 94 patients with gastric carcinoma, verified by histologic examinations, were enrolled. the serum level of pgi in each patient was measured by radioimmunoassay. mean serum pgi levels were 95.4 +/- 39.4 ng/ml in patients with gastric ulcers, 77.6 +/- 29.3 ng/ml in healthy volunteers, and 52.1 +/- 26.5 ng/ml in ... | 1993 | 7904845 |
| eradication of helicobacter pylori infection and the recurrence of duodenal ulcers. | the purpose of this study was to compare the performance of different regimens on helicobacter pylori (h. pylori) eradication and duodenal ulcer recurrence. during a four-week period, 59 patients with duodenal ulcers who were positive for h. pylori infection were randomly treated with one of three regimens. seventeen patients were treated with ranitidine, 19 with colloidal bismuth subcitrate (cbs), and 23 with triple therapy (cbs, tetracycline and metronidazole). forty-six patients with healed u ... | 1993 | 7904847 |
| [advances in gastrointestinal peptides: somatostatin]. | twenty years after being identified as "somatotropin release inhibiting factor" (srif) and "growth-hormone release inhibiting hormone" (gh-rih), under a new name, somatostatin (sms) has reached an outstanding position in gastroenteropancreatic endocrinology. it is a powerful and universal inhibitor of the digestive functions: secretion, motility, absorption and splanchnic blood flow. long-acting synthetic analogues have made possible its therapeutic trial in certain clinical problems. this revie ... | 1993 | 7910493 |
| molecular cloning of helicobacter pylori dna: important differences between mcrbc deletion host strains. | 1993 | 7934864 | |
| helicobacter pylori prevalence in northeastern thailand. | helicobacter pylori is distributed worldwide and has been demonstrated in thailand. however, no study has been conducted so far in northeastern thailand. the objective of this study was to find the prevalence of h. pylori in patients undergoing upper gastrointestinal endoscopy in northeastern part of thailand. one hundred and twenty-six patients undergoing surgery between november 1992 and january 1993 were studied. biopsies were done at antrum, corpus, and other positive lesions. diagnostic tes ... | 1993 | 7939950 |
| helicobacter pylori and acid secretion. | helicobacter pylori has been implicated in the aetiopathogenesis of peptic ulcer but data on the effect of infection by this organism on gastric acid secretion are equivocal. we, therefore, examined the effect of the presence of helicobacter pylori in the antrum and body of the stomach on acid secretion. | 1993 | 7950929 |
| functional dyspepsia: where do we stand? | despite its high prevalence, our understanding of the pathophysiology and therapy of functional or nonulcer dyspepsia is very limited. because of differences in definition, diagnostic work-up and patient or population characteristics, interpretation of published studies on functional dyspepsia is difficult. recently developed new proposals, such as the role of helicobacter pylori in the pathogenesis and the clinical relevance of dividing dyspeptic patients into subgroups based on clusters of sym ... | 1993 | 7912448 |
| [the isolation of helicobacter pylori from the gastric juice]. | gastric contents was examined in 49 patients with duodenal bulb ulcers. helicobacter pylori were isolated in 83.7% of cases. h. pylori density was found to be 10(3)-10(5) microbial cells per ml. bacterioscopic studies with gram staining helped detect h. pylori in 79.6% of cases, cultural method revealed the bacteria in 63.3%, and urease test in 4.1% of cases. poor efficacy of urease test is explained by its poor sensitivity (10(6) microbial cells per ml or higher). the authors analyze the freque ... | 1993 | 7994536 |
| [infection with helicobacter pylori as a risk factor for stomach cancer]. | 1993 | 8008654 | |
| serological examinations in patients with helicobacter pylori infections. | a passive microhemagglutination test was applied for the detection of h. pylori antibodies. the presence of elevated antibody titers was most frequently encountered in the sera of patients from whom h. pylori was isolated. no relationship between the level of antibodies and the clinical picture of peptic ulcer disease was noted. in addition, negative results from bacteriologic and serologic studies in patients with confirmed histopathologic changes and typical clinical symptoms may suggest that ... | 1993 | 8010871 |
| evaluation of three serological tests for the detection of helicobacter pylori associated infection. | biopsy specimens and serum samples from 140 patients with duodenal or gastric ulcer disease were examined. the presence of helicobacter pylori was detected in 105 out of 140 subjects. three testing techniques used in this study led to different results. thus, the enzyme-linked immunosorbent essay enabled detection of elevated igg antibodies to h. pylori in 108 serum samples. passive microhemagglutination and latex agglutination, "pyloriset" led to the detection of elevated titers in 102 and 83 s ... | 1993 | 8010872 |
| [tests of helicobacter pylori survival in milk]. | the survival of microaerophilic bacteria helicobacter pylori (hp) isolated from gastric mucosa was studied in 2 ml and 10 ml samples of milk contaminated with a suspension of these bacteria in 20% glucose solution. milk was kept at 5-7 degrees c temperature in refrigerator and at room temperature. hp was found in samples kept at 5-7 degrees c during 3 days. on the other hand, hp was not found after 24-hours keeping at room temperature. | 1993 | 8016539 |
| pathophysiology and treatment of functional dyspepsia. | functional dyspepsia (or 'non-ulcer') is usually defined as chronic or intermittent upper abdominal symptoms for which no organic cause can be found. division of functional dyspepsia into subgroups such as reflux-like, ulcer-like, dysmotility-like and non-specific dyspepsia has been proposed, but lacks a scientific basis. gastric acid hypersecretion, helicobacter pylori-associated gastritis, gastric and small intestinal motor disorders, psychological and neurohormonal factors all might play a ro ... | 1993 | 8016577 |
| attachment of helicobacter pylori to human gastric epithelium mediated by blood group antigens. | helicobacter pylori is associated with development of gastritis, gastric ulcers, and adenocarcinomas in humans. the lewis(b) (le(b)) blood group antigen mediates h. pylori attachment to human gastric mucosa. soluble glycoproteins presenting the leb antigen or antibodies to the leb antigen inhibited bacterial binding. gastric tissue lacking leb expression did not bind h. pylori. bacteria did not bind to leb antigen substituted with a terminal galnac alpha 1-3 residue (blood group a determinant), ... | 1993 | 8018146 |
| [the pathological consequences of helicobacter infection in man and the new developments in treating peptic ulcer (based on the materials from the european gastroenterology week, 21-26 october 1991, amsterdam]. | 1993 | 8036585 | |
| [non-ulcer dyspepsia syndrome]. | in one thousand of 1500 examinees with nonulcerous dyspepsia the syndrome was due to chronic gastritis, duodenitis and gastroduodenitis, in five hundred of them it was attributed to probable dysfunction of the upper gastrointestinal tract. morphological evidence of chronic gastritis activity is essential but not the only factor affecting the dyspepsia syndrome. of importance are also motor dysfunctions: high intragastric and/or intraduodenal pressure, unbalance of intracavitary pressure paramete ... | 1993 | 8046898 |
| [current problems in the etiology of ulcer]. | 1993 | 8046911 | |
| [the immunological aspects of the antibacterial therapy of peptic ulcer patients]. | essence and potency of immunological effects produced by some anti-bacterial drugs used in the treatment of peptic ulcer were determined in the course of immunological survey of patients. trichopol and--to the less extent--furazolidone were established to provide immunocorrective effect and prevent exacerbation better than amoxicillin. the latter, to the contrary, aggravates secondary immune deficiency. | 1993 | 8030316 |
| antigen profile of helicobacter pylori strains isolated from peptic ulcer patients in dhaka, bangladesh. | the whole-cell-extract and the acid-extract preparations of helicobacter pylori strains isolated from peptic ulcer patients and the nctc 11638 control strain were studied to compare their antigen profiles. besides, the anti-h. pylori-antibody profile in serum from h. pylori-infected peptic ulcer patients were also studied to define the antigen stimulating specific anti-h. pylori-antibody response in the infected patients. the whole-cell extract (wce) and the acid-extract (ae) preparations showed ... | 1993 | 8031286 |
| prevalence of helicobacter pylori infection in patients with peptic ulcer diseases and non-ulcer dyspepsia. | helicobacter pylori is known to be a cause of active chronic gastritis and has been proposed as an etiologic factor in the development of peptic ulcer disease, but controversy continues regarding the pathogenic importance and mechanism. we examined the prevalence of h. pylori infection in patients with peptic ulcers and non-ulcer dyspepsia. | 1993 | 8031726 |
| [hla, blood group, secretory factor, pepsinogen i, and helicobacter pylori in duodenal ulcer patients]. | duodenal ulcer is a multifactorial entity where a genetic predisposition and extrinsic elements seem to concur in its origin. a series of genetic and extrinsic markers were determined in 50 patients with duodenal ulcer and 50 controls matched by age, sex and socioeconomical status. hla antigens dit not have significant differences. blood group o rh+ was predominant (p < 0.01). secretor status of antigen hbo in saliva was positive in 70% of patients (p < 0.001). serum pepsinogen i was increased i ... | 1993 | 8050704 |
| acid-peptic disease: helicobacter pylori and omeprazole: great advances but clinical problems remain. | 1993 | 8055219 | |
| helicobacter pylori: a primer for 1994. | ten years after the original isolation of helicobacter pylori, we know that this interesting new bacterium infects half of the world's population and at least 25% of people in the united states. the mode of transmission is probably fecal-oral, and its prevalence increases in lower socioeconomic groups or older people. fortunately, the organism can now be diagnosed using serology, breath testing, biopsy, and culture. we also have effective means of therapy in the united states giving 80 to 95% cu ... | 1993 | 8055220 |
| helicobacter pylori: practical guidelines for diagnosis and treatment. | ulcer disease can be cured in most patients. the discovery of an infectious cause of peptic disease has necessitated new diagnostic and treatment strategies for common upper gastrointestinal tract problems. appropriate use of one of the many new tests to diagnose helicobacter pylori can identify those individuals likely to benefit from antimicrobial treatment. further refinement of antimicrobial regimens should ensure better patient compliance and maximize effective bacterial eradication. h. pyl ... | 1993 | 8055226 |
| serological diagnosis of infection by helicobacter pylori in chronic ulcer disease. | the authors estimated the frequency of occurrence of the infection by helicobacter pylori in the long term gastroduodenal ulcer disease. the serological diagnosis (elisa test) was carried out in 175 patients, suffering from this disease for at least two years, to reveal the existence of specific igg against helicobacter pylori. the study confirmed the frequent occurrence of infection by helicobacter pylori in the gastro-duodenal ulcer disease of the stomach (59.2%) and the duodenum (83.7%). it w ... | 1993 | 8072313 |
| progress with proton pump inhibitors in acid peptic disease: treatment of duodenal and gastric ulcer. | to date, the primary therapeutic approach to peptic ulcer disease, either gastric or duodenal ulcer, remains the inhibition of gastric acid secretion. the major therapeutic goals in peptic ulcer disease are symptom relief, acceleration of crater healing, and the prevention of relapse or recurrence. since the introduction of h2-receptor antagonists and proton pump inhibitors, the full control of acid secretion can be achieved. in the treatment of gastric ulcer, analysis of all studies that have c ... | 1993 | 7911399 |
| [exudative enteropathy and gastritis caused by helicobacter pylori in children]. | 1993 | 8053778 | |
| [the effect of helicobacter pylori on the development of complications in the stomach and duodenum of patients with rheumatic diseases]. | biopsy material of gastric mucosa obtained from 94 patients with rheumatic diseases was subjected to bacterioscopic, biochemical and microbiological studies. helicobacter pylori was found in 29% of patients with rheumatism, in 34.3% of patients with rheumatic arthritis and in 39.9% of those suffering from osteoarthrosis deformans. the study confirms that the microorganisms found in gastric and duodenal mucosa should be considered as a saprophytic microflora which promotes inflammatory process. | 1993 | 8085360 |
| treatment of helicobacter pylori-associated gastroduodenal disease in children. clinical evaluation of antisecretory vs antibacterial therapy. | the charts of 54 children diagnosed with antral h. pylori were reviewed, to establish the incidence of gastroduodenal inflammation and compare therapeutic efficacies of antisecretory vs. antibacterial therapy. histology demonstrated normal mucosa in three cases (6%) and gastric/duodenal inflammation (> or = whitehead grade 3) in 51 biopsies (94%). 23/43 children (53%) initially responded to h2-blockers; however, by 10 mo, 13 had relapsed clinically. all of these patients subsequently responded t ... | 1993 | 8093598 |
| h pylori-initiated ulcerogenesis: look to the host. | 1993 | 8093924 | |
| helicobacter pylori in dental plaque. | 1993 | 8094153 | |
| pcr identification of helicobacter pylori in faeces from gastritis patients. | 1993 | 8094221 | |
| uncomplicated peptic ulcer disease. an overview of formation and treatment principles. | the end point in peptic ulcer disease is a crater in the mucosa. the cause of gastric ulcers seems to be the breakdown of defensive factors, which then allows damage from endogenous and/or exogenous aggressive factors. aggressive factors are more important in duodenal ulcer formation. treatment options discussed herein have similar clinical effectiveness, and all have better results than placebo. selection of a specific agent should be individualized. helicobacter pylori infection has been impli ... | 1993 | 8095330 |
| refractory peptic lesions. therapeutic strategies for ulcers and reflux esophagitis that resist standard regimens. | in some patients, peptic lesions fail to heal after 2 to 3 months of standard histamine2 (h2) receptor antagonist or sucralfate (carafate) therapy. noncompliance with prescribed treatment, cigarette smoking, gastric acid hypersecretory states (including zollinger-ellison syndrome), helicobacter pylori infection, the use of nonsteroidal anti-inflammatory drugs, abdominal radiation therapy, and malignant tumors are all causes of refractory disease. treatment options include high-dose h2 receptor a ... | 1993 | 8095331 |