Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [dmw (deutsche medizinische wochenschrift) walter siegenthaler prize]. | 2000 | 11036479 | |
| [infection thesis as explanation of the higher incidence of myocardial infarction in males]. | 2000 | 11036489 | |
| [impact of chlamydia pneumoniae infections on asthma]. | viruses and bacteria: the fact that the airways are exposed to a large number of infectious agents could explain the frequency of respiratory infections and their causal effect in bronchial inflammation. viruses are most often the causal agent, but the frequency of bacterial infections make them potential candidates in certain respiratory diseases. chlamydia are particularly important due to their capacity to provoke immune dysfunction and chronic inflammation. effect on asthma: it is not surpri ... | 2000 | 11036520 |
| [percentage of asthmatic patients with acute bronchitis and chlamydia pneumoniae seropositivity]. | 2000 | 11036523 | |
| segmental manifestation of peripheral atherosclerosis and its association to risk factors. | to prove whether the aortoiliac, femoropopliteal or crural segments of the peripheral arteries might have a different sensitivity to a risk profile we did a statistical analysis of segmental peripheral atherosclerosis and risk factors. | 2000 | 11037718 |
| microorganisms in the aetiology of atherosclerosis. | recent publications have suggested that infective pathogens might play an important role in the pathogenesis of atherosclerosis. this review focuses on these microorganisms in the process of atherosclerosis. the results of in vitro studies, animal studies, tissue studies, and serological studies will be summarised, followed by an overall conclusion concerning the strength of the association of the microorganism with the pathogenesis of atherosclerosis. the role of the bacteria chlamydia pneumoni ... | 2000 | 11041053 |
| the use of serologic tests for the diagnosis of chlamydial infections. | serology is commonly used for the diagnosis of acute chlamydia pneumoniae infections and also for the diagnosis of complicated chlamydia trachomatis infections. furthermore, recent sero-epidemiological studies have linked c. pneumoniae infection with several diseases traditionally considered non-infectious. the objectives of this mini-review are to critically review and discuss some selected analytical and methodological aspects, controversies and current problems in chlamydial serodiagnosis. to ... | 2000 | 11044570 |
| controversies in neurological infectious diseases. | the past several years have seen major advances in our understanding of neurological infectious diseases, their diagnosis, and their treatment. along with these advances, however, new information about infectious agents and new therapeutic options have also introduced both uncertainty and controversy in the approach and management of patients with diseases of the central nervous system. here, we discuss six such areas: the long-term efficacy of haart therapy in treatment of hiv infection; the ro ... | 2000 | 11051301 |
| the epidemiology of respiratory tract infections. | respiratory tract infections (rtis) are the most common, and potentially most severe, of infections treated by health care practitioners. lower rtis along with influenza, are the most common cause of death by infection in the united states. risk factors for pneumonia and other respiratory tract infections include: extremes of age (very young and elderly), smoking, alcoholism, immunosuppression, and comorbid conditions. the microbial cause of rtis vary depending on the infection (i.e., pneumonia ... | 2000 | 11052419 |
| meningoencephalitis and chlamydia pneumoniae infection. | 2000 | 11054150 | |
| inflammatory cells, apoptosis and chlamydia pneumoniae infection in atherosclerosis. | chlamydia pneumoniae (cp), chromosomal alterations and apoptosis were suggested as contributing factors in the pathogenesis of atherosclerosis. early (ep) and unstable plaques (up) were studied in order to assess infiltrate composition, the apoptotic index, chromosome 7 stability and to investigate the concurrent presence of cp in ep and up. paraffin embedded sections of three iliac arteries and four aortas from young donors (ep), and four coronaries and nine carotid arteries (up) were used. asi ... | 2000 | 11054502 |
| picornavirus proteins share antigenic determinants with heat shock proteins 60/65. | immunological cross-reactions between enteroviruses and islet cell autoantigens have been suggested to play a role in the etiopathogenesis of insulin dependent diabetes mellitus (iddm). in the nonobese diabetic mouse, an autoimmune model of iddm, one of the reactive beta cell autoantigens is the heat shock protein 60 (hsp60). these studies were prompted by sequence homology discovered between the immunogenic region in hsp60 and two regions in enterovirus capsid proteins, one in the vp1 protein a ... | 2000 | 11055249 |
| [spectrum of pneumotropic pathogens in pediatric patients with acute bronchitis and pneumonia]. | one hundred eighty nine children with acute bronchopulmonary infectious pathological processes were examined bacteriologically and serologically for typical pneumotropic pathogens, 47 of them being as well examined for atypical organisms. microbial associations mainly with mycoplasma and pneumocystis and to a lesser extent with chlamydia were isolated from the majority of the children. reactivation of the cytomegalovirus infection was observed in 25 per cent of the children. pneumonia and bronch ... | 2000 | 11057368 |
| [comparison of various diagnostic kits and antigens for the detection of chlamydial antibodies in the serum of patients with respiratory diseases] . | examination of sera of patients with respiratory diseases did not reveal any substantial difference in detection of chlamydial antibodies by elisa using two commercial kits (chlamydia stat and rrlisa) demonstrating igg antibodies and two corpuscular antigens prepared from chlamydia psittaci and chlamydia pneumoniae in the institute of virology, sas, in bratislava detecting whole serum antibodies. however, higher sensitivity of relisa diagnostic kit was found when analyzing immunoglobulin classes ... | 2000 | 11059109 |
| is chlamydia pneumoniae present in brain lesions of patients with multiple sclerosis? | we investigated the presence of chlamydia pneumoniae in 81 normal and pathological specimens obtained from postmortem brain tissues of patients with multiple sclerosis and with other neurological or nonneurological diseases. the assays used included pcr amplification of all dna samples in the initial study. culture and a second pcr amplification of the organism in a subset of 19 brain specimens were also performed in two separate laboratories. all results were negative. thus, this study on a lar ... | 2000 | 11060110 |
| [inflammation, infection and coronary artery disease: myths and realities. special xxxv conference of the national congress of the spanish society of cardiology]. | in the past decades it has become apparent that inflammation plays a role in atherogenesis and rapid coronary artery disease progression. active, or vulnerable, atheromatous plaques are responsible for acute coronary events and contain high concentrations of inflammatory cells as well as molecules involved in the inflammatory process, such as cytokines, adhesion molecules and growth factors. from a clinical perspective, early detection of these plaques may prevent the occurrence of serious coron ... | 2000 | 11060248 |
| community-acquired pneumonia in adolescents. | community acquired pneumonia (cap) is defined as pneumonia acquired outside of the hospital setting. extensive studies of cap in adolescents that characterize the true incidence of various etiologic pathogens are not available. however, streptococcus pneumoniae, mycoplasma pneumoniae, and chlamydia pneumoniae appear to be the most frequently encountered pathogens. these organisms often cause cap in adults as well; other infections are noted as well, including legionella. "atypical pneumonia" ref ... | 2000 | 11060562 |
| the association of infection and coronary artery disease: an update. | numerous studies have reported an association of coronary atherosclerosis and restenosis with certain bacterial and viral infections. this article reviews the pathophysiology of atherosclerosis, the role of infectious agents (cytomegalovirus, chlamydia pneumoniae and helicobacter pylori) in atherogenesis and studies supporting the potential beneficial effects of antibiotics or antiviral agents in the management of atherosclerotic disease. the interactions of cytomegalovirus and the arterial wall ... | 2000 | 11060816 |
| inflammation and infection in acute coronary syndrome. | basic science research has revealed that monocytes and macrophages are important factors in atherogenesis. immune system activation occurs at all stages of plaque formation, from the fatty streak to an advanced, complicated lesion. the inflammatory response not only stimulates changes in coronary artery endothelial cells causing endothelial injury and dysfunction, but also plays a role in plaque instability and rupture. new perspectives of atherosclerosis and acute coronary syndromes will be dis ... | 2000 | 11061218 |
| elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. | periodontitis is a common, often undiagnosed, chronic infection of the supporting tissues of the teeth, epidemiologically associated with cardiovascular diseases. since c-reactive protein (crp) and other systemic markers of inflammation have been identified as risk factors for cardiovascular diseases, we investigated whether these factors were elevated in periodontitis. | 2000 | 11063384 |
| identification of periodontal pathogens in atheromatous plaques. | recent studies suggest that chronic infections including those associated with periodontitis increase the risk for coronary vascular disease (cvd) and stroke. we hypothesize that oral microorganisms including periodontal bacterial pathogens enter the blood stream during transient bacteremias where they may play a role in the development and progression of atherosclerosis leading to cvd. | 2000 | 11063387 |
| chlamydia pneumoniae, herpes simplex virus type 1, and cytomegalovirus and incident myocardial infarction and coronary heart disease death in older adults : the cardiovascular health study. | whether serological evidence of prior infection with chlamydia pneumoniae, herpes simplex virus type 1 (hsv-1), and cytomegalovirus (cmv) is associated with myocardial infarction (mi) and coronary heart disease (chd) death remains a source of controversy. | 2000 | 11067785 |
| detection of chlamydia pneumoniae dna in cd3+ lymphocytes from healthy blood donors and patients with coronary artery disease. | chlamydia pneumoniae is an intracellular bacterium responsible for respiratory tract infections. recent studies have implicated this organism in the pathogenesis of atherosclerosis. | 2000 | 11067786 |
| [chlamydia pneumoniae pneumonia]. | 2000 | 11068505 | |
| the possible role of hepatitis a virus in the pathogenesis of atherosclerosis. | the possible association between hepatitis a virus (hav) infection and coronary artery disease (cad) was studied. blood from 391 patients undergoing coronary angiography was tested for serum igg antibodies to hav and c-reactive protein (crp). of the 391 patients, 205 (52%) had anti-hav igg antibodies. cad prevalence was 74% in hav-seropositive and 52% in hav-seronegative patients (p<.0001); significance persisted after adjustment for either traditional cad risk factors or for risk factors plus o ... | 2000 | 11069227 |
| infection and activation of airway epithelial cells by chlamydia pneumoniae. | the activation of primary human airway epithelial cells (haecs) and of the bronchial epithelial cell line beas-2b by chlamydia pneumoniae, an important respiratory pathogen, was characterized. a time-dependent enhanced release of interleukin (il)-8 and prostaglandin-e(2) and an increased expression of the epithelial adhesion molecule intercellular adhesion molecule-1 (icam-1), followed by subsequent transepithelial migration of polymorphonuclear neutrophils (pmn), were also demonstrated. the tra ... | 2000 | 11069240 |
| chlamydia pneumoniae igg seropositivity in deep-vein thrombosis. | 2000 | 11075796 | |
| chlamydia pneumoniae antibodies and angiographically demonstrated coronary artery disease in thailand. | recent reports have suggested an association between chlamydia pneumoniae and coronary artery disease. this study investigated the relationship between the presence of immunoglobulin g (igg), immunoglobulin a (iga) of c. pneumoniae in angiographically diagnosed coronary disease. patients enrolled were 243 (178 male, 65 female, mean age 61 +/- 10 years) with angiographically proven at least one significant coronary artery stenosis. fifty-eight patients (33 male, 25 female, mean age 57 +/- 11 year ... | 2000 | 11075973 |
| replication orientation affects the rate and direction of bacterial gene evolution. | in many bacterial genomes, the leading and lagging strands have different skews in base composition; for example, an excess of guanosine compared to cytosine on the leading strand. we find that chlamydia genes that have switched their orientation relative to the direction of replication, for example by inversion, acquire the skew of their new "host" strand. in contrast to most evolutionary processes, which have unpredictable effects on the sequence of a gene, replication-related skews reflect a ... | 2000 | 11080368 |
| community-acquired pneumonia: etiology, epidemiology, and outcome at a teaching hospital in argentina. | to survey the etiology and epidemiology of community-acquired pneumonia (cap) in relation to age, comorbidity, and severity and to investigate prognostic factors. | 2000 | 11083685 |
| cell-mediated immune response during primary chlamydia pneumoniae infection. | the development of chlamydia pneumoniae-specific cell-mediated immunity was studied during a primary c. pneumoniae infection. the immune response was detected as positive lymphocyte proliferation and secretion of interferon gamma. c. pneumoniae-induced activation of both cd4(+) and cd8(+) t cells was detected in the early phase of infection, but activation of only cd4(+) t cells was detected in the later stage. | 2000 | 11083846 |
| effect of chlamydia trachomatis infection on atherosclerosis in apolipoprotein e-deficient mice. | we have previously demonstrated that chlamydia pneumoniae accelerates plaque formation in apolipoprotein e-deficient (apoe(-/-)) mice following intranasal inoculations. in this study, we evaluated the effect of respiratory tract infection with chlamydia trachomatis on the progression of atherosclerosis in apoe(-/-) mice. the study showed that in contrast to infection with chlamydia pneumoniae, infection of the lung and aorta with c. trachomatis was mild and transient and did not significantly ac ... | 2000 | 11083855 |
| failure to detect chlamydia pneumoniae in the central nervous system of patients with ms. | 2000 | 11087807 | |
| unstable atherosclerotic plaques contain t-cells that respond to chlamydia pneumoniae. | atherosclerotic lesions are characterized by an immune mediated chronic inflammation. seroepidemiological studies support a relationship between atherosclerotic disease and infection with c. pneumoniae; an association further endorsed by immunocytochemical and dna directed studies. however, the question arises whether c. pneumoniae acts as a causal antigen, or is merely a bystander. for this reason we have analyzed the t lymphocyte population of carotid atherosclerotic plaques of symptomatic pat ... | 2000 | 11090835 |
| temporal arteritis associated with chlamydia pneumoniae dna detected in an artery specimen. | temporal arteritis is a clinical manifestation of giant cell arteritis. the etiology of this disease is still unknown. sudden onset and wide variations of incidence are reported in different parts of the world. acute onset is often associated with flu-like symptoms, indicating that infectious factors probably act as precipitating agents. we describe a 72-year-old man referred to our department in january 1999 for unremitting fever and temporal arteritis associated with chlamydia pneumoniae infec ... | 2000 | 11093461 |
| detection of chlamydia pneumoniae in giant cell vasculitis and correlation with the topographic arrangement of tissue-infiltrating dendritic cells. | recent studies suggest that giant cell arteritis (gca) may be an antigen-driven disease. since chlamydia pneumoniae has been identified in arterial vessel walls, it was hypothesized that this organism might be associated with gca. | 2000 | 10902759 |
| heart disease and the inflammatory response. | 2000 | 10903629 | |
| low grade inflammation and coronary heart disease: prospective study and updated meta-analyses. | to assess associations between baseline values of four different circulating markers of inflammation and future risk of coronary heart disease, potential triggers of systemic inflammation (such as persistent infection), and other markers of inflammation. | 2000 | 10903648 |
| chlamydia pneumoniae infection and mortality from ischaemic heart disease: large prospective study. | to determine whether there is an independent association between infection with chlamydia pneumoniae and ischaemic heart disease. | 2000 | 10903649 |
| chlamydia pneumoniae igg titres and coronary heart disease: prospective study and meta-analysis. | to examine the association between coronary heart disease and serum markers of chronic chlamydia pneumoniae infection. | 2000 | 10903653 |
| chlamydia pneumoniae and atherosclerosis. identification of bacterial dna in the arterial wall. | the intracellular gram-negative bacterium chlamydia pneumoniae has been associated with atherosclerosis. the presence of chlamydia pneumoniae has been investigated in fragments of the arterial wall with a technique for dna identification. | 2000 | 10904285 |
| great amount of c.pneumoniae in ruptured plaque vessel segments at autopsy. a comparative study with stable plaques. | a possible relationship between c.pneumoniae (cp) infection, atherosclerosis and acute myocardial infarction is a debated matter. now we performed the search of cp in histological segments of fatal ruptured plaques and of stable plaques by histochemistry (macchiavello stain), immunohistochemistry and in situ hybridization techniques. electron microscopy and confocal laser microscopy techniques were used in two additional cases. the semi-quantification of cp + cells (0-4+) and quantification of l ... | 2000 | 10904288 |
| detection of viral and bacterial protein in endomyocardial biopsies of patients with inflammatory heart muscle disease? | the development of highly sensitive molecular biological methods such as in-situ hybridization and polymerase chain reaction (pcr) made it possible to detect viral/bacterial nucleic acid in human endomyocardial biopsies. however, only a few investigations addressed the problem of latent persistence of viral and bacterial genome and the detection of the corresponding proteins, which could have important consequences for the clinical course of the disease. the purpose of this study was to determin ... | 2000 | 10904844 |
| chlamydia pneumoniae igg seropositivity and risk of deep-vein thrombosis. | in a population-based case-control study of 474 patients with a first episode of deep-vein thrombosis and 474 age-matched and sex-matched controls, we found no effect of chlamydia pneumoniae infection on the occurrence of deep-vein thrombosis. | 2000 | 10905248 |
| autoimmunity in atherosclerosis. the role of autoantigens. | 2000 | 10907109 | |
| the role of bacterial infections in asthma. | in summary, bacterial organisms are clinically relevant contributors to asthma exacerbations, and have received much less attention than viruses in this process. streptococcus pneumoniae, hemophilus influenzae, and moraxella catarrhalis have been linked to asthma exacerbations, particularly when sinusitis is present. treatment therefore should be directed toward these organisms if a bacterial cause is suspected. the atypical bacteria--specifically, c. pneumoniae and m. pneumoniae--deserve specia ... | 2000 | 10907590 |
| ubiquitous pathogens: links between infection and autoimmunity in ms? | 2000 | 10908883 | |
| [is atherosclerosis an infectious disease]. | 2000 | 10909147 | |
| frequency of serological evidence of bordetella infections and mixed infections with other respiratory pathogens in university students with cough illnesses. | banked acute-phase and convalescent-phase serum samples from a previous study of respiratory illness in university students were examined for significant (>/=2-fold) increases in elisa titers of iga and igg antibody to bordetella pertussis filamentous hemagglutinin, pertactin, and fimbriae-2 and >/=4-fold titer increases to agglutinogens by agglutination. elisa titers of antibody to pertussis toxin could not be determined because of technical problems. chlamydia pneumoniae infections were diagno ... | 2000 | 10913388 |
| severe chlamydia pneumoniae infection in patients with neutropenia: case reports and literature review. | three cases of life-threatening c. pneumoniae infection in patients with acute leukemia and treatment-induced neutropenia are described. diagnosis was made on the basis of the detection of c. pneumoniae-dna, complemented by serology. the role of the widely distributed respiratory tract pathogen c. pneumoniae in febrile neutropenia is poorly understood, and studies are needed to estimate the frequency of severe pulmonary infection caused by this agent in patients with neutropenia. | 2000 | 10913419 |
| diagnosis of chlamydia pneumoniae in community-acquired pneumonia in children in chile. | the incidence of chlamydia pneumoniae in community-acquired pneumonia in children was studied prospectively in 112 children aged 1 mo to 14 y. diagnosis of c. pneumoniae was performed by polymerase chain reaction (pcr) on nasopharyngeal aspirates and serology by the microimmunofluorescence test on a single serum specimen. three (2.7%) cases of pneumonia due to this agent were diagnosed by both pcr and serology. c. pneumoniae was not found in any of 62 children below 5 y of age. in the age group ... | 2000 | 10914956 |
| [the value of bronchoalveolar lavage in the clarifying of hiv-associated lung diseases]. | examination of sputum is the first diagnostic step in the evaluation of hiv-infected patients with pulmonary complications. we were interested in the indications and the diagnostic value of subsequent bronchoscopy and bronchoalveolar lavage (bal) and especially the importance of so-called atypical bacteria. | 2000 | 10916494 |
| does infection have a role in the pathogenesis of coronary artery disease? | 2000 | 10917081 | |
| respiratory infections and asthma. | clinical and experimental evidence suggests an important role for respiratory infections in the development of asthma attacks. viral upper respiratory infections have been associated with 80% of asthma exacerbations in children and 50% of all asthma episodes in adults. human rhinovirus has been implicated as the principal virus associated with asthma episodes. separate studies indicate that atypical bacteria such as chlamydia pneumoniae and mycoplasma pneumoniae may precipitate asthma symptoms. ... | 2000 | 10919505 |
| infections, atherosclerosis, and coronary heart disease. | there is growing evidence that the immune response is involved in atherosclerosis. studies done over the past several years have shown an association between markers of inflammation and coronary atherosclerosis with an exacerbation of the inflammatory process during acute myocardial ischemia. overall, these data have greatly renewed interest in the infectious theory of atherosclerosis and coronary heart disease. search of bibliographic databases (from january 1991 through december 1999) and manu ... | 2000 | 10920505 |
| the naval health research center respiratory disease laboratory. | concern about emerging and reemerging respiratory pathogens prompted the development of a respiratory disease reference laboratory at the naval health research center. professionals working in this laboratory have instituted population-based surveillance for pathogens that affect military trainees and responded to threats of increased respiratory disease among high-risk military groups. capabilities of this laboratory that are unique within the department of defense include adenovirus testing by ... | 2000 | 10920635 |
| emerging relations between infectious diseases and coronary artery disease and atherosclerosis. | cardiovascular disease is the leading cause of death in developed countries. the cause is multifactorial. a substantial proportion of patients with coronary artery disease (cad) do not have traditional risk factors. infectious diseases may play a role in these cases, or they may intensify the effect of other risk factors. the association of cad and chlamydia pneumoniae infection is firmly established, but causality is yet to be proven. the link with other infectious agents or conditions, such as ... | 2000 | 10920732 |
| treatment of chlamydia pneumoniae. | 2000 | 10926449 | |
| t lymphocyte lines isolated from atheromatous plaque contain cells capable of responding to chlamydia antigens. | chlamydia pneumoniae infection is associated with atherosclerosis and the organism has been identified in arterial lesions. to determine whether t lymphocyte-mediated immune responses to chlamydia antigens within plaque could contribute to pathogenesis, we have derived t cell lines from atherosclerotic plaques of 32 patients. culture with il-2 alone proved insufficient for cellular activation and expansion, but additional stimulation with phytohaemagglutinin (pha) or recall antigens allowed cons ... | 2000 | 10931140 |
| chlamydia pneumoniae antibodies and adult-onset asthma. | 2000 | 10932089 | |
| [diagnostic procedures in chlamydia pneumoniae infections]. | 2000 | 10932409 | |
| chlamydia pneumoniae infection in adults with chronic cough compared with healthy blood donors. | in a small uncontrolled study, persistent cough has recently been found to be associated with serological evidence of acute chlamydia pneumoniae infection. in order to assess whether c. pneumoniae plays a role in chronic cough, the prevalence of c. pneumoniae infection in 201 adult patients with chronic cough was compared with the prevalence in 106 healthy blood donors without respiratory tract symptoms in the preceding 3 months. a microimmunofluorescence antibody test was used to determine c. p ... | 2000 | 10933094 |
| coronary heart disease and chlamydia pneumoniae dna in blood mononuclear cells. | 2000 | 10933387 | |
| serological analysis of specific iga to chlamydia pneumoniae: increased sensitivity of iga antibody detection using prolonged incubation and high antigen concentration. | the microimmunofluorescence technique (mif) is recognized as the only test hitherto allowing discrimination between different chlamydia species and is considered to be the reference method for serology. this method was developed for the detection of igg and igm antibodies only. we investigated the effects of some test parameters on the ability of mif to detect chlamydia pneumoniae iga. these parameters were the time needed for binding of serum iga to c. pneumoniae antigen and the effect of antig ... | 2000 | 10937773 |
| effect of prior exposure to chlamydia pneumoniae, helicobacter pylori, or cytomegalovirus on the degree of inflammation and one-year prognosis of patients with unstable angina pectoris or non-q-wave acute myocardial infarction. | inflammation and chronic infections may be important features in the pathogenesis of acute coronary syndromes. we describe 6 systemic markers of inflammation in patients with unstable angina or non-q-wave myocardial infarction and the relations between these markers, seropositivity to chronic infections, and prognosis. c-reactive protein (crp), serum amyloid a protein (saa), fibrinogen, interleukin-6 (il-6), neopterin, procalcitonin, and serum antibody levels to chlamydia pneumoniae, helicobacte ... | 2000 | 10946028 |
| characterization of the rnpb gene and rnase p rna in the order chlamydiales. | the sequence of the rnase p rna gene (rnpb) was determined for 60 strains representing all nine species in the family chlamydiaceae and for the related chlamydiales species, parachlamydia acanthamoebae and simkania negevensis. these sequences were used to infer evolutionary relationships among the chlamydiaceae. the analysis separated chlamydophila and chlamydia into two lineages, with chlamydophila forming three distinct clusters: the chlamydophila pneumoniae strains; the chlamydophila pecorum ... | 2000 | 10826799 |
| seroprevalence of antibodies to chlamydia pneumoniae in elderly people: a two-decade longitudinal and cohort difference study. | a gerontological population of 178 men and 249 women was investigated regarding the prevalence of antibodies specific to chlamydia pneumoniae. a longitudinal substudy was carried out on 22 men and 44 women, age range 70-90 y. antibodies specific to c. pneumoniae were common. men had higher prevalences and higher antibody levels than women. more than half of the individuals in the longitudinal study had significant igg and/or iga titre changes (> or = 4-fold) between the ages of 70 and 90 y, sugg ... | 2000 | 10826904 |
| atherogenetically relevant cells support continuous growth of chlamydia pneumoniae. | the obligate intracellular bacterium chlamydia pneumoniae has been implicated in the pathogenesis of atherosclerosis since viable pathogen has been recovered from plaques. chlamydiae are epithelial pathogens notorious for causing persistent infection. atherosclerosis, however, is a chronic inflammatory disease involving mesenchymal cells of the vascular wall. a bacterial contribution to atherosclerosis appears more relevant if the resident mesenchymal cells of the vascular wall that constitute t ... | 2000 | 10829241 |
| immune responses to chlamydia antigens in atherosclerosis. | aim of this study was to isolate t lymphocytes from atheromatous plaques and to determine they respond to chlamydia antigens. atheromatous plaques from carotid endarterectomy patients, were cultured in vitro with the t cell growth factor, il-2. this rarely allowed outgrowth of t cell lines. however, when combined with a mitogenic or antigenic stimulus to t cells, t cell lines were obtained from most patients, and from approximately 30% of replicate plaque tissue fragments. chlamydia organisms we ... | 2000 | 10829242 |
| chlamydia pneumoniae infection is not an independent risk factor for arterial disease. | appreciation of atherosclerosis as an infectious disease has fostered interest in the role that chlamydia pneumoniae may play in atheroma development. although data from seroepidemiological and experimental studies have established an association between the pathogen and atherosclerosis, little is known about how the organism contributes to lesion development. atherosclerosis is a complex disease process and the role of any pathogen must be considered in the context of other risk factors. here w ... | 2000 | 10829243 |
| pathogenesis of atherosclerosis: infectious versus immune pathogenesis. a new concept. | a novel concept for the pathogenesis of atherosclerosis is presented that obviates the need to search for a causative infectious agent. it is shown that ldl stranded in the subendothelium is transformed by enzymatic (non-oxidative) modification to yield an entity with complement- and macrophage-activating properties. this primarily serves to clear the stranded lipoprotein from tissues. however, sustained overactivation of complement and macrophages occurs when ldl-deposition is too extensive. a ... | 2000 | 10829244 |
| impact of chronic infection with chlamydia pneumoniae on incidence of cardiac allograft vasculopathy. | chronic infection with chlamydia pneumoniae (cp) is associated with development of coronary disease. however, little information exists concerning cp infection and impact on posttransplant cardiac allograft vasculopathy (cav). a total of 202 patients were investigated 5.5+/-3.1 years after cardiac transplantation (46.5+/-11.0 years; 169 male, 33 female). assessment of cav was performed by annual coronary angiograms. chlamydia serology (igg/iga) was performed using micro-immunofluorescence. stati ... | 2000 | 10830242 |
| a search for beta-lactamase in chlamydiae, mycoplasmas, planctomycetes, and cyanelles: bacteria and bacterial descendants at different phylogenetic positions and stages of cell wall development. | bacteria from different phylogenetic positions such as chlamydiae, mycoplasmas, planctomycetes and also endosymbiotic murein-containing cyanelles were investigated for the production of beta-lactamases. no beta-lactamase activity was found in bacteria lacking murein such as chlamydia pneumoniae, mycoplasma pneumoniae, pirellula marina and planctomyces maris. in the murein-containing cyanelles of cyanophora paradoxa no beta-lactamase activity could be detected. | 2000 | 10830893 |
| isolation and continuous growth of chlamydia pneumoniae from arterectomy specimens. | for the purpose of collecting chlamydia pneumoniae strains of vascular origin that could be grown continuously in vitro, a cell culture system has been established. using different types of vascular specimens obtained from 38 patients, chlamydia pneumoniae could be isolated in three (7.9%) cases. the strains were obtained from specimens of the carotid artery, the femoral artery and an infrarenal aneurysm of the abdominal aorta of three male atherosclerosis patients. thus, viable chlamydia pneumo ... | 2000 | 10834822 |
| chlamydia pneumoniae serological status is not associated with asthma in children or young adults. | the factors that cause the allergic sensitization and inflammation in asthma still remain to be clarified. a role for chlamydia pneumoniae has been suggested although serological studies have produced conflicting findings. this study aims to clarify the relationship between asthmatic variables and c. pneumoniae serological status. | 2000 | 10817126 |
| type iii secretion system in chlamydia species: identified members and candidates. | chlamydia trachomatis and chlamydia pneumoniae genomes contain genes coding for type iii secretion apparatuses. like other pathogens, chlamydia probably uses this system to secrete proteins in the host cell. with the aim of identifying such proteins, we analyzed the organization of chlamydia type iii secretion genes. | 2000 | 10817638 |
| effect of azithromycin plus rifampin versus amoxicillin alone on eradication and inflammation in the chronic course of chlamydia pneumoniae pneumonitis in mice. | the effects of treatment with azithromycin plus rifampin (a+r), amoxicillin (a), or placebo (p) on the chronic course of experimental chlamydia pneumoniae pneumonitis in mice were assessed by culture, pcr, and immunocytochemistry as well as by degree of inflammation in lung tissue. eradication of the pathogen was significantly more frequent and inflammation in tissue was significantly reduced after treatment with a+r compared to after treatment with a or p. combination therapy with azithromycin ... | 2000 | 10817751 |
| prior cytomegalovirus, chlamydia pneumoniae or helicobacter pylori infection and the risk of restenosis after percutaneous transluminal coronary angioplasty. | we investigated a possible correlation between the serologic status concerning cytomegalovirus (cmv), chlamydia pneumoniae (cp) and helicobacter pylori (hp) and the occurrence of restenosis in patients undergoing percutaneous transluminal coronary angioplasty for symptomatic coronary artery disease. tests for anti-cmv igg, anti-chlamydia pneumoniae igg and iga and hp igg and iga were performed with an enzyme-linked immunosorbent assay (elisa). restenosis was defined as >/=50% stenosis at follow- ... | 2000 | 10817856 |
| lack of association between kawasaki syndrome and infection with parvovirus b19, human herpesvirus 8, tt virus, gb virus c/hepatitis g virus or chlamydia pneumoniae. | 2000 | 10819350 | |
| chronic infection and coronary risk. | 2000 | 10819711 | |
| microbiological efficacy of levofloxacin for treatment of community-acquired pneumonia due to chlamydia pneumoniae. | 2000 | 10819727 | |
| role of infections in the pathogenesis of atherosclerotic coronary artery disease: past, present and future. | 2000 | 10820941 | |
| infection-susceptibility alleles of mannose-binding lectin are associated with increased carotid plaque area. | the mbl gene, encoding mannose-binding lectin, determines interindividual variation in susceptibility to certain infectious agents, such as chlamydia pneumoniae. we examined whether infection-susceptibility alleles of mbl, called "non-a alleles," would be associated with increased carotid plaque area (cpa), an intermediate phenotype of atherosclerosis. in 164 subjects, we measured cpa with 2-dimensional ultrasound. we also determined traditional atherosclerosis risk factors and genotyped all sub ... | 2000 | 10822900 |
| antibody response to the 60-kda heat-shock protein of chlamydia pneumoniae in patients with coronary artery disease. | serum specimens from 752 individuals undergoing coronary arteriography were examined for antibodies to chlamydia pneumoniae. patients with coronary artery disease (cad) were more likely to have igg antibodies to c. pneumoniae than were individuals without cad (60% vs. 52%; p=.007; odds ratio, 1.8; 95% confidence interval, 1. 17-2.77). antibodies to recombinant hsp60 of c. pneumoniae were found with nearly the same frequency in patients with cad and individuals without cad (29% vs. 30%; p=.751). ... | 2000 | 10823771 |
| oxidation of low-density lipoproteins by acellular components of chlamydia pneumoniae. | 2000 | 10823809 | |
| activity of gemifloxacin and other new quinolones against chlamydia pneumoniae: a review. | quinolones are currently used as empirical therapy for treatment of community-acquired lower respiratory infections as they are effective against a broad range of conventional bacterial and 'atypical' pathogens, including chlamydia pneumoniae. c. pneumoniae is estimated to be associated with 10-20% of community-acquired pneumonia in adults, and has recently been suggested to play a role in several non-respiratory conditions, including atherosclerosis. the newer, third-generation quinolones have ... | 2000 | 10824030 |
| seropositivity against chlamydia pneumoniae in patients with coronary atherosclerosis. | results of therapy in patients with unstable coronary syndromes with antibiotics directed against chlamydia pneumoniae have been variable, perhaps due to the heterogeneity of patients in these trials. | 2000 | 10803439 |
| evidence for infection with chlamydia pneumoniae in a subgroup of patients with multiple sclerosis. | in a pilot study, we identified chlamydia pneumoniae in the cerebrospinal fluid by polymerase chain reaction in 5 of 10 patients with definite multiple sclerosis (ms). in a second series, 2 of 20 patients with definite ms and 3 of 17 patients with possible/probable ms or ms variants, but none of 56 patients with other neurological, diseases were polymerase chain reaction-positive. we confirm that c. pneumoniae can be found in the cerebrospinal fluid of ms patients, but our rate of positive resul ... | 2000 | 10805338 |
| chlamydia pneumoniae infection in community-acquired pneumonia in taiwan. | chlamydia pneumoniae is a common cause of pneumonia worldwide. this study examined the role of c. pneumoniae in 229 patients with community-acquired pneumonia. the ages of the patients ranged from 2 to 95 years. sera were assayed for igm and igg antibodies with microimmunofluorescence (mif). an igm titer equal to or greater than 1:20 and igg titer equal to or greater than 1:64 were considered positive. the prevalence of positive igg among all of the patients was 75.1% (172/229). the seroprevalen ... | 2000 | 10806962 |
| azithromycin vs cefuroxime plus erythromycin for empirical treatment of community-acquired pneumonia in hospitalized patients: a prospective, randomized, multicenter trial. | to compare the efficacy and safety of azithromycin dihydrate monotherapy with those of a combination of cefuroxime axetil plus erythromycin as empirical therapy for community-acquired pneumonia in hospitalized patients. | 2000 | 10809032 |
| [atherosclerosis: an infectious disease?]. | 2000 | 10815300 | |
| infections and atherosclerosis. | more than a century ago, inflammation and infection were considered to have atherogenic effects. during last century, however, this hypothesis was completely abandoned, and the old idea that coronary heart disease (chd) possibly has an infectious etiology has only re-emerged in recent years. both viral and bacterial pathogens have been proposed to be associated with the inflammatory changes found in atherosclerosis. herpes group viruses, especially cytomegalovirus (cmv) and herpes simplex virus ... | 2000 | 10816055 |
| production of basic fibroblast growth factor and interleukin 6 by human smooth muscle cells following infection with chlamydia pneumoniae. | chlamydia pneumoniae infection has been associated with asthma and atherosclerosis. smooth muscle cells represent host cells for chlamydiae during chronic infection. in this study we demonstrated that c. pneumoniae infection of human smooth muscle cells in vitro increased production of interleukin 6 (il-6) and basic fibroblast growth factor (bfgf) as shown by reverse transcription-pcr, immunoblotting, and enzyme-linked immunosorbent assay. in contrast, levels of platelet-derived growth factor a- ... | 2000 | 10816522 |
| chlamydia pneumoniae inhibits apoptosis in human peripheral blood mononuclear cells through induction of il-10. | chlamydia pneumoniae is a common cause of pulmonary infection, with serum positivity in at least 50% of the general population. in this study, we report that human pbmcs exposed to c. pneumoniae are resistant to apoptosis induced by the potent photoactivated chemotherapeutic agents 8-methoxypsoralen and hypericin. in contrast, pbmcs treated with a heat-inactivated inoculum exhibit normal susceptibility to apoptosis. we also observed that human pbmcs are responsive to c. pneumoniae infection by s ... | 2000 | 10799921 |
| evaluation of a commercial test for antibodies to the chlamydial lipopolysaccharide (medac) for serodiagnosis of acute infections by chlamydia pneumoniae (twar) and chlamydia psittaci. | a commercial test (relisa) based on a recombinant chlamydial lipopolysaccharide (lps) antigen has been evaluated for the diagnosis of acute infections caused by chlamydia pneumoniae (twar) and chlamydia psittaci. this test and a microimmunofluorescence test (mif) were compared in 160 patients with community-acquired pneumonia. seventeen of nineteen cases with significant titre changes detected by relisa were confirmed by mif. the two remaining cases not confirmed by mif were considered false-pos ... | 2000 | 10737458 |
| the resistance of human monocyte-derived macrophages to chlamydia pneumoniae infection is enhanced by interferon-gamma. | chlamydia pneumoniae is an intracellular bacterium which commonly causes respiratory infections. chronic infections have been associated with atherosclerosis and the organism has been detected in macrophages in the disease lesions. growth of chlamydiae in different epithelial cell lines is restricted by interferon-gamma (ifn-gamma), a monocyte activator produced by t cells. we have studied the influence of ifn-gamma on the growth and infectivity of c. pneumoniae in hl-cells and human monocyte-de ... | 2000 | 10737459 |
| chlamydia pneumoniae and lipoprotein(a): the right combination for atherosclerosis? | 2000 | 10731393 | |
| the proatherogenic properties of lipoprotein(a) may be enhanced through the formation of circulating immune complexes containing chlamydia pneumoniae-specific igg antibodies. | to investigate a possible relationship between the atherogenic properties of lipoprotein(a) (lp(a)) and chlamydia pneumoniae infections. | 2000 | 10731401 |
| protective dna immunization against chlamydia pneumoniae. | we have investigated the efficacy of the dna vaccination using the heat shock protein 60 (hsp-60) gene of c. pneumoniae, for protection of mice against infection with the bacteria. c57bl/6 mice had a 5-20-fold reduction of c. pneumoniae numbers in lungs when immunized intranasally (i.n.) with plasmids (p) encoding phsp-60. the reduction of the bacterial load coincided with a decreased severity of disease. no specific antibodies were detected after protective i. n. immunization. in contrast, mice ... | 2000 | 10736106 |
| chlamydia pneumoniae in coronary artery disease. | 2000 | 10736300 |