Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| detection of epstein-barr virus and kaposi's sarcoma-associated herpesvirus dna in csf from persons infected with hiv who had neurological disease. | to determine the frequency and clinical relevance of epstein-barr virus (ebv) and kaposi's sarcoma associated herpesvirus (kshv) dna detection in the csf from patients infected with hiv. | 1998 | 9703169 |
| disseminated kaposi's sarcoma after heart transplantation: association with kaposi's sarcoma-associated herpesvirus. | kaposi's sarcoma is an endothelial tumor rarely diagnosed after heart transplantation. we report on a patient originally from africa in whom kaposi's sarcoma developed in association with kaposi's sarcoma-associated herpesvirus. | 1998 | 9703241 |
| emerging viruses in blood transfusion. | 1998 | 9704434 | |
| pcr assay fails to detect molluscum contagiosum virus-related sequences in aids-related kaposi's sarcoma. | previous pcr-based studies have demonstrated the presence of various viral dna or rna sequences in kaposi's sarcoma (ks) tissues. to date, only human herpesvirus 8 (hhv-8) dna sequences are found consistently in ks. the putative role of this agent in ks pathogenesis remains, however, to be determined; hhv-8 could infect populations endemically and could be reactivated in patients with ks. a close association between aids-related ks and molluscum contagiosum occurrence was found and this study wa ... | 1998 | 9705179 |
| human herpesvirus 8 detection in nasal secretions and saliva. | the presence of human herpesvirus 8 (hhv-8) was determined by polymerase chain reaction (pcr) in nasal secretions and saliva from 14 hhv-8-seropositive persons, including 8 kaposi's sarcoma patients: 7 were human immunodeficiency virus type 1-infected, 6 of whom were asymptomatic. hhv-8 was detected in one or both body fluids in 8 (57%) of 14 subjects. parallel pcr testing revealed the concomitant presence of cytomegalovirus, epstein-barr virus, and hhv-6 in various combinations in these body fl ... | 1998 | 9419191 |
| kaposi's sarcoma associated herpesvirus deoxyribonucleic acid sequences: lack of detection in prostatic tissue of human immunodeficiency virus-negative immunocompetent adults. | a recent study argued that kaposi's sarcoma associated herpesvirus is ubiquitous, as reflected by the frequent detection of its deoxyribonucleic acid (dna) sequences in the prostatic tissue of healthy italian men. because these findings are discordant with serological data, our objective was to reassess the prevalence of this virus in prostate tissue from immunocompetent men. | 1998 | 9400458 |
| establishing a kshv+ cell line (bcp-1) from peripheral blood and characterizing its growth in nod/scid mice. | kaposi's sarcoma-associated herpesvirus (kshv or hhv8) sequences are present in primary effusion lymphomas (pel). kshv+ cell lines have been established from such lymphomas. here we report the first description of the establishment of a kshv+, ebv- cell line (bcp-1) from the peripheral blood of a patient with pel. using this cell line and a kshv+, ebv+ pel cell line (hbl-6) previously established from ascitic fluid, we investigated whether in nonobese diabetic/severe combined immunodeficiency di ... | 1998 | 9473233 |
| diagnosis of pulmonary kaposi's sarcoma by detection of human herpes virus 8 in bronchoalveolar lavage. | human herpes virus 8 (hhv8) dna has recently been detected in sarcoma tissue of patients with kaposi's sarcoma. hhv8 dna could also be found in bronchoalveolar lavage (bal) fluid of patients with tracheobronchial kaposi's sarcoma. to determine the specificity, sensitivity and predictive values of hhv8 dna detection in the bal for the diagnosis of pulmonary kaposi's sarcoma, 100 consecutive bal were prospectively analyzed for the presence of hhv8 dna using a nested pcr assay. in addition, 19 bal ... | 1998 | 9476858 |
| inhibition of constitutive signaling of kaposi's sarcoma-associated herpesvirus g protein-coupled receptor by protein kinases in mammalian cells in culture. | kaposi's sarcoma-associated herpesvirus (kshv)/human herpesvirus 8, which is consistently present in tissues of patients with kaposi's sarcoma and primary effusion lymphomas, contains a gene that encodes a g protein-coupled receptor (kshv-gpcr). we recently showed that kshv-gpcr exhibits constitutive signaling via activation of phosphoinositide-specific phospholipase c and stimulates cell proliferation and transformation. in this study, we determined whether normal cellular mechanisms could inhi ... | 1998 | 9480990 |
| kaposi's sarcoma (ks), ks-associated herpesvirus, and the criteria for causality in the age of molecular biology. | 1998 | 9482495 | |
| does human herpesvirus 8 have a pathogenetic role in primary cns lymphoma? | 1998 | 9484343 | |
| human herpesvirus 8 dna in cns lymphomas from patients with and without aids. | human herpesvirus 8 (hhv-8) has been found in association with kaposi's sarcomas in human immunodeficiency virus (hiv)-positive and -negative patients, primary effusion lymphomas (pels), multicentric castleman's disease, and multiple myeloma. the pels share several features with acquired immunodeficiency syndrome (aids)-associated primary central nervous system lymphomas (1 degree cns-l), including b-cell phenotype, infection with epstein-barr virus, and lack of c-myc gene rearrangements. this p ... | 1998 | 9484350 |
| human herpesvirus 8-specific dna sequences in primary cutaneous b-cell lymphomas. | 1998 | 9487226 | |
| the ul6 locus of pseudorabies virus and its homology to oncogenic herpesviruses. | the ul6 locus of pseudorabies virus (prv) was analyzed to reveal a gene cluster with homology to herpes simplex virus ul5, ul6, ul7 and ul8, epstein-barr virus bbrf1 and bbrf2, and kaposi sarcoma-associated herpes virus orf43 and orf42. the noncoding region between prv ul7 and ul8 contained 16 copies of a 14 bp t + c-rich repeat element. the mrna start sites for ul6 and ul7 were mapped by primer extension and ul6 was expressed in vitro. the mobility of the in vitro-expressed ul6 protein correlat ... | 1998 | 9458304 |
| cardiac tamponade in a patient with aids: a review of pericardial disease in patients with hiv infection. | pericarditis in patients with human immunodeficiency virus (hiv) infection may be asymptomatic or symptomatic, but is sometimes overlooked because of signs and symptoms of other organ system diseases. a case report of cardiac tamponade in a patient with acquired immunodeficiency syndrome (aids) is presented. to determine the incidence and causes of pericardial disease in patients with hiv infection, a review of the literature was conducted. fifteen autopsy and echocardiographic series involving ... | 1998 | 9458682 |
| polymerase chain reaction detection of human herpesvirus 8 sequences in primary central nervous system lymphomas. | 1998 | 9466554 | |
| etiology and outcome of lower gastrointestinal bleeding in patients with aids. | the objective of the study was to investigate bleeding (lgib) in patients with acquired immunodeficiency syndrome (aids). | 1998 | 9468236 |
| regression of aids-related kaposi's sarcoma associated with clearance of human herpesvirus-8 from peripheral blood mononuclear cells following initiation of antiretroviral therapy. | 1998 | 9468373 | |
| randomized comparative trial of pegylated liposomal doxorubicin versus bleomycin and vincristine in the treatment of aids-related kaposi's sarcoma. international pegylated liposomal doxorubicin study group. | cytotoxic chemotherapy is frequently required for the more severe manifestations of human immunodeficiency virus (hiv)-related kaposi's sarcoma. combinations of bleomycin and vincristine (bv) or bv with the addition of doxorubicin (abv) are the most commonly used regimens against which new treatments may be compared. we report a multicenter phase iii study that compared pegylated liposomal doxorubicin (pld) to the bv combination. | 1998 | 9469358 |
| seroprevalence of kaposi's sarcoma-associated herpes virus antibody in young adult hodgkin's disease. | 1998 | 9439351 | |
| transcription mapping of the kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) genome in a body cavity-based lymphoma cell line (bc-1). | kaposi's sarcoma-associated herpesvirus (kshv) gene transcription in the bc-1 cell line (kshv and epstein-barr virus coinfected) was examined by using northern analysis with dna probes extending across the viral genome except for a 3-kb unclonable rightmost region. three broad classes of viral gene transcription have been identified. class i genes, such as those encoding the v-cyclin, latency-associated nuclear antigen, and v-flip, are constitutively transcribed under standard growth conditions, ... | 1998 | 9444993 |
| gamma-interferon produced by cd8+ t cells infiltrating kaposi's sarcoma induces spindle cells with angiogenic phenotype and synergy with human immunodeficiency virus-1 tat protein: an immune response to human herpesvirus-8 infection? | kaposi's sarcoma (ks) is an angioproliferative disease associated with infection by the human herpesvirus-8 (hhv-8). hhv-8 possesses genes including homologs of interleukin-8 (il-8) receptor, bcl-2, and cyclin d, which can potentially transform the host cell. however, the expression of these genes in ks tissues is very low or undetectable and hhv-8 does not seem to transform human cells in vitro. in addition, ks may not be a true cancer at least in the early stage. this indicated that besides it ... | 1998 | 9446657 |
| gamma-interferon production in peripheral blood mononuclear cells and tumor infiltrating lymphocytes from kaposi's sarcoma patients: correlation with the presence of human herpesvirus-8 in peripheral blood mononuclear cells and lesional macrophages. | evidence indicates that, at least in the early stage, kaposi's sarcoma (ks) is a cytokine-mediated disease and that it is consistently associated with a novel herpesvirus termed human herpesvirus-8 (hhv-8). to gain insights into the mechanisms by which cytokines and hhv-8 may cooperate in disease pathogenesis, we examined the phenotype, the th1 (gamma-interferon [gamma ifn]) and th2 (interleukin-4 [il-4] cytokine profile and the presence of hhv-8 in peripheral blood mononuclear cells (pbmc), tum ... | 1998 | 9446658 |
| diagnostic implication of kaposi's sarcoma-associated herpesvirus with special reference to the distinction between spindle cell hemangioendothelioma and kaposi's sarcoma. | to assess the diagnostic utility of recently identified kaposi's sarcoma-associated herpesvirus (kshv, also referred to as human herpesvirus 8) in distinction between kaposi's sarcoma (ks) and other types of vascular lesion, especially spindle cell hemangioendothelioma (sch). | 1998 | 9448021 |
| identification and characterization of human herpesvirus-8 lytic cycle-associated orf 59 protein and the encoding cdna by monoclonal antibody. | monoclonal antibody (mab) 11d1 specific for hhv-8 showed a predominantly nuclear membrane fluorescence with about 30% of phorbol ester (tpa)-induced hhv-8-carrying bcbl-1 cells and with 2-8% of uninduced cells, but not with other herpes viruses infected cells. this mab immunoprecipitated a 50-kda polypeptide from bcbl-1 cells. the synthesis of this polypeptide was reduced but not inhibited by phosphonoacetic acid (paa). a 2.3-kb cdna insert from a cdna library of tpa-induced bcbl-1 cells was ide ... | 1998 | 9448696 |
| seroprevalence of kaposi's sarcoma-associated herpes virus antibody in young adult hodgkin's disease | 1998 | 9427732 | |
| kaposi's sarcoma. coupling herpesvirus to angiogenesis. | 1998 | 9422503 | |
| g-protein-coupled receptor of kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. | the kaposi's sarcoma-associated herpesvirus (kshv/hhv8) is a gamma-2 herpesvirus that is implicated in the pathogenesis of kaposi's sarcoma and of primary effusion b-cell lymphomas (pels). kshv infects malignant and progenitor cells of kaposi's sarcoma and pel, it encodes putative oncogenes and genes that may cause kaposi's sarcoma pathogenesis by stimulating angiogenesis. the g-protein-coupled receptor encoded by an open reading frame (orf 74) of kshv is expressed in kaposi's sarcoma lesions an ... | 1998 | 9422510 |
| human herpesvirus 8 encodes an interferon regulatory factor (irf) homolog that represses irf-1-mediated transcription. | human herpesvirus 8 (hhv-8) is the probable viral etiologic agent for kaposi's sarcoma. the hhv-8 genome encodes viral interferon regulatory factor (virf), a gene product that has homology to the irf family of transcription factors. we demonstrate that virf inhibits responses to type i and type ii interferons and blocks irf-1-mediated transcription. virf does not compete with irf-1 for binding to dna or complex directly with irf-1. the ability of virf to block irf-1-mediated transcription is ind ... | 1998 | 9420276 |
| opportunistic infections shortly after beginning highly active antiretroviral therapy. | the clinical benefit of highly active antiretroviral therapy (haart) has been attributed to its suppression of viral replication and improvement in the cd4 lymphocyte count. however, the development of clinical symptoms secondary to previously silent opportunistic pathogens shortly after beginning haart has been reported as a distinct clinical syndrome and seems to be associated with inflammatory phenomena surrounding a rapid restoration of the immune system in previously immunosuppressed patien ... | 1998 | 10682143 |
| wide-ranging progress on ks therapies. | potent anti-hiv therapies are decreasing the number of new cases of kaposi's sarcoma; however, 25,000 americans are still living with the aids-defining disease. the pathogenesis of the disease is still not understood and no cure is in sight, although progress has been made in treating the disease. the progression of the disease and some cytokines and growth factors that trigger it are described. a kaposi's sarcoma (ks) herpesvirus was identified in 1994 (kshv or hhv-8); the prevalence of kshv ma ... | 1998 | 11365219 |
| puzzling out new data on kaposi's sarcoma. | preventing kaposi's sarcoma (ks) in the united states is relatively manageable, largely through safer sexual practices and access to antiretroviral therapy. however, in africa the disease is endemic, and its high prevalence could be a precursor of higher rates elsewhere in the world. the declining ks rates in the united states may mean that drug companies have little motivation to develop vaccines and therapies to fight the disease. some new data may offer an explanation for why ks behaves so di ... | 1998 | 11365464 |
| occult gastrointestinal kaposi's sarcoma in an hiv-infected african man. | a case report is presented of a 33-year-old hiv-positive african-american male who was diagnosed with occult gastrointestinal kaposi's sarcoma (ks). symptoms, diagnosis, and treatment efforts are detailed. it was hoped that treatment with a triple antiretroviral regimen would resolve his gastrointestinal symptoms, however, the patient experienced adverse effects which were attributed to the antiretroviral treatment. these adverse effects continued even after the treatment ceased; a decision was ... | 1998 | 11365606 |
| treatment of gynecological conditions in women. | women with hiv who have certain gynecologic conditions, such as yeast infections or particular pre-cancerous lesions, may require higher doses of medicine to treat these conditions. other disorders like gonorrhea, chlamydia, and pelvic inflammatory disease seem to require similar treatment responses for hiv-positive and hiv negative women. studies validate that women with hiv, especially those with decreasing cd4+ counts, are more likely to have several human papillomavirus (hpv) infections, whi ... | 1998 | 11365842 |
| clinical profile of aids: a study at a referral hospital. | the present study describes the clinical and epidemiological features of 74 patients with human immunodeficiency virus (hiv) infection who presented to a referral hospital. sixty two patients (83.7%) were diagnosed to have acquired immune deficiency syndrome (aids). mean age of the patients was 34.9 +/- 12 years and male to female ratio was 3:1. majority of patients (80%) were from lower socio-economic class. multiple unprotected heterosexual contact with commercial sex workers in metropolitan c ... | 1998 | 11229245 |
| kshv study recruiting at columbia. | 1998 | 11362005 | |
| viral studies in rheumatic disease. | rheumatic disease has long been thought to represent an interaction between environmental agents on a background of genetic susceptibility. in this review herpesviruses and retroviruses are considered as possible aetiological agents in autoimmune disease with a particular emphasis on sjögren's syndrome. a possible role for cytomegalovirus, epstein-barr virus (ebv), human herpesvirus-6 (hhv-6) and human herpesvirus-8 (hhv-8) is reviewed. we conclude that there is no compelling evidence for the in ... | 1998 | 11490514 |
| the aids dilemma: drug diseases blamed on a passenger virus. | almost two decades of unprecedented efforts in research costing us taxpayers over $50 billion have failed to defeat acquired immune deficiency syndrome (aids) and have failed to explain the chronology and epidemiology of aids in america and europe. the failure to cure aids is so complete that the largest american aids foundation is even exploiting it for fundraising: 'latest aids statistics-0,000,000 cured. support a cure, support amfar.' the scientific basis of all these unsuccessful efforts ha ... | 1998 | 10220905 |
| complete histological regression of kaposi's sarcoma following treatment with protease inhibitors despite persistence of hhv-8 in lesions. | there is no current curative treatment for hiv-related kaposi's sarcoma. the identification of human herpesvirus-8 as a possible aetiological agent suggests potential efficacy of anti-viral agents. we report here on the complete histological remission of kaposi's sarcoma following treatment with protease inhibitors, even in patients with limited virological response and persistence of hhv-8. | 1998 | 10225394 |
| kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor confers resistance to the antiproliferative effect of interferon-alpha. | kaposi's sarcoma-associated herpesvirus (kshv) encodes a 442 amino acid polypeptide-designated viral interferon regulatory factor (virf) that displays homology to members of the interferon regulatory factor (irf) family that bind to consensus interferon sequences and transactivate cellular genes that can modulate growth inhibition. studies were conducted to determine whether virf affects the growth suppression mediated by interferon-alpha (ifn-alpha) in a human b lymphocyte cell line. | 1998 | 10780883 |
| human herpesvirus 8 and sarcoidosis. | 1998 | 10326573 | |
| aids-related malignancies. | overview of malignancy in patients with aids: despite the advent of highly active antiretroviral therapy, the incidence of human immunodeficiency virus (hiv)-associated malignancies has not decreased. the united states centers for disease control (cdc) has determined that kaposi's sarcoma, non-hodgkin's lymphoma (including primary central nervous system lymphoma), and cervical carcinoma define the acquired immune deficiency syndrome (aids). some literature reports include hodgkin's disease, anal ... | 1998 | 10388117 |
| aids-related kaposi's sarcoma patients with visceral manifestations. response to human chorionic gonadotropin preparations. | in vitro cell culture studies and a murine model for human kaposi's sarcoma (ks) have shown that human chorionic gonadotropin (hcg)-associated factor (haf) isolated from commercial hcg preparations has antiproliferative and cell killing effects on neoplastic ks cells, without toxic effects on normal endothelial cells and lymphocytes. these findings prompted preliminary study of hcg preparations for patients with early-stage ks with skin lesions only and no known visceral involvement. complete or ... | 1998 | 10195236 |
| hiv-1, hhv-8, and kaposi's sarcoma. | 1998 | 10195240 | |
| kaposi's sarcoma in the gambia, west africa is less frequent in human immunodeficiency virus type 2 than in human immunodeficiency virus type 1 infection despite a high prevalence of human herpesvirus 8. | to investigate the distribution of kaposi's sarcoma (ks) cases in patients with human immunodeficiency virus types 1 and 2 (hiv-1 and hiv-2) infection in the gambia; to document the prevalence of human herpesvirus 8 (hhv-8) infection in various population groups in the gambia. | 1998 | 10195242 |
| seroprevalence of kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 in several regions of italy. | to study the seroprevalence of kaposi's sarcoma-associated herpesvirus/human herpesvirus type 8 (kshv/hhv-8) in 779 italian blood donors. | 1998 | 10195244 |
| distinct serum cytokines in aids-related skin diseases. | to determine whether common skin diseases associated with human immunodeficiency virus (hiv) were distinguishable based on the pattern of serum cytokine expression, we studied patients with psoriasis, pruritus, and kaposi's sarcoma (ks) for levels of tumor necrosis factor (tnf)-alpha, interferon-gamma (ifn-y), interleukin (il)-10, and il-4. thirty-two hiv-positive (hiv+) patients including 8 with ks, 11 with psoriasis, and 13 with pruritus along with 16 hiv-negative subjects with psoriasis were ... | 1998 | 10189188 |
| non-human immunodeficiency virus kaposi's sarcoma can be effectively treated with low-dose interferon-alpha despite the persistence of herpesvirus-8. | three patients, negative for human immunodeficiency virus (hiv), with histologically and polymerase chain reaction-proven non-hiv kaposi's sarcoma who received low-dose interferon (ifn) as first-line treatment because of disseminated symptomatic disease are reported. applying 3-18 million iu of ifn-alpha 2a per day, 3 days a week, subcutaneously for 8-20 months, major responses were achieved in all three cases. tumour regression was observed within 4 months and has continued for 57 and 18 months ... | 1998 | 9990371 |
| seroprevalence of human immunodeficiency virus type 1 infection in childhood malignancy in zimbabwe. | to determine the association between malignancy and the human immunodeficiency virus type 1 (hiv-1) infection in children. | 1998 | 10101432 |
| localization of human herpesvirus type 8 (hhv-8) in the kaposi's sarcoma tissues and the semen specimens of hiv-1 infected and uninfected individuals by utilizing in situ polymerase chain reaction. | kaposi's sarcoma (ks) is a form of skin cancer, most commonly found in individuals suffering from acquired immunodeficiency syndrome, or aids. however, before the worldwide infection of human immunodeficiency virus (hiv), the rare occurrence of ks was confined to two distinct groups of individuals. in the western world, the classical form of ks was often found in older men (60-70 years of age) from the mediterranean area. another form called endemic ks, was found in equatorial africa. currently, ... | 1998 | 10213307 |
| incidence of acquired immunodeficiency syndrome (aids)-related kaposi's sarcoma in the aquitaine cohort, france, 1988-1996. groupe d'epidémiologie clinique du sida en aquitaine. | to assess secular trends of the incidence of kaposi's sarcoma (ks) between 1988 and 1996 in the aquitaine cohort of human immunodeficiency virus type 1 (hiv1)-infected subjects (southwestern france). | 1998 | 10024207 |
| [laboratory diagnosis of viral infections. 7. opportunistic infection by herpesviruses (human cytomegalovirus, epstein-barr virus, and human herpesvirus 8)]. | 1998 | 9921237 | |
| epidemiology, etiology and pathogenesis, clinical presentations and therapeutic approaches in kaposi's sarcoma: 15-year lessons from aids. | kaposi's sarcoma (ks) is a leading cause of morbidity among 25-30% of aids patients and is by far the most common aids-associated malignancy. since the beginning of the 1990s the incidence of ks continuously declined, but it was the introduction of protease inhibitors that markedly reinforced this phenomenon. in our experience, the annual incidence was 59/1,000 patient-years in 1984 vs 21.2/1,000 patient-years in 1990, 12.5/1,000 patient-years in 1996, with a drop to 3.2/1,000 patient-years in 1 ... | 1998 | 9921413 |
| molecular piracy: the viral link to carcinogenesis. | the vast majority of the human experience with viral infections is associated with acute symptoms, such as malaise, fever, chills, rhinitis and diarrhea. with this acute or lytic phase, the immune system mounts a response and eliminates the viral agent while acquiring antibodies to that specific viral subtype. with latent or chronic infections, the viral agent becomes incorporated into the human genome. viral agents capable of integration into the host's genetic material are particularly dangero ... | 1998 | 9930354 |
| timing and necessity of endoscopy in aids patients with dysphagia or odynophagia. | dysphagia and odynophagia are common problems with significant morbidity in acquired immunodeficiency syndrome (aids) patients. endoscopy in aids patients with esophageal symptoms is valuable for diagnosis, but the timing and necessity of routine endoscopy remains controversial. | 1998 | 9951891 |
| kaposi's sarcoma pathogenesis: a link between immunology and tumor biology. | kaposi's sarcoma (ks) was a rare disease in europe and north america until a decade ago, when it became the most common neoplasm complicating the acquired immunodeficiency syndrome (aids), where it acquires an aggressive course. clinical and experimental data suggest that, at least in early stage, ks may not be a true sarcoma, but an hyperplastic-proliferative lesion that may regress. at least three components characterize ks lesions: (1) neoangiogenesis and proliferation of spindle-shaped cells ... | 1998 | 9973245 |
| viruses and human cancer. | several kinds of viruses cause cancer in humans, accounting for 10-20% of cancer worldwide. human cancer viruses include human papillomavirus, hepatitis b virus, epstein-barr virus, human t cell lymphotropic virus, and kaposi's sarcoma-associated herpesvirus. cancer viruses alter the machinery of the infected cell to promote their own survival and growth. in the process, they interfere with normal cellular control mechanisms, leading to abnormal growth, genetic alterations and malignancy. studie ... | 1998 | 10093516 |
| human herpesvirus-8 orf k8.1 gene encodes immunogenic glycoproteins generated by spliced transcripts. | a cdna library from phorbol ester-induced human herpesvirus-8 (hhv-8) carrying bcbl-1 cells was screened with an hiv+ks+ serum, and several cdna clones encoding hhv-8 proteins were identified. sequence analysis of two full-length cdna clones show open reading frames (orfs) encoded by spliced messages originating from the hhv-8 k8.1 gene. one cdna encodes an orf of 228 amino acids, designated k8. 1.a, with a cleavable signal sequence, a transmembrane domain, and four n-glycosylation sites. the sp ... | 1998 | 9740785 |
| the absence of hhv-8 dna sequences in skin tumours other than kaposi's sarcoma from aids patients and transplant recipients. | 1998 | 9892968 | |
| hypothesis. hhv-8 in multiple myeloma: is this the first paracrine model of human tumorigenesis and do koch's postulates apply? | 1998 | 9893745 | |
| drug abuse and acquired immune deficiency syndrome. | acquired immune deficiency syndrome (aids) is a modern plague. the first sign of the disease was the appearance of pneumocystis carinii and kaposi's sarcoma among young homosexual patients. the virus transmission is from an infected individual to a susceptible host through blood-related, sexual, and perinatal routes. exchange of body fluid occurs when sharing syringes, drugs, and drug paraphernalia. although the largest number of people infected with human immunodeficiency virus (hiv) is in subs ... | 1998 | 9895137 |
| kaposi's sarcoma-associated herpesvirus (kshv) chemokine vmip-ii and human sdf-1alpha inhibit signaling by kshv g protein-coupled receptor. | kaposi's sarcoma-associated herpesvirus (kshv) encodes two proteins that are similar to human cc chemokines and a g protein-coupled receptor (kshv-gpcr) that is constitutively active. kshv-gpcr binds a number of human cxc and cc chemokines. we showed that interferon gamma-inducible protein-10 (ip-10), a human cxc chemokine, inhibits kshv-gpcr signaling (geras-raaka et al., j. exp. med. 188, 405-408, 1998). here we show that viral monocyte inflammatory protein-ii (vmip-ii), one of the kshv-encode ... | 1998 | 9918794 |
| hhv8 status in kaposi's sarcoma associated with multiple myeloma. | kaposi's sarcoma in its sporadic or hiv-related form is due to a gamma herpesvirus, the human herpes virus 8 (hhv8). no data have been published on the potential role of the hhv8 in kaposi's sarcoma occurring in multiple myeloma patients. a case is reported of a patient in whom four serum samples taken between the diagnosis of multiple myeloma and the occurrence of a kaposi's sarcoma one year later tested positive for antibody to the hhv8. similar findings have been reported in patients with oth ... | 1998 | 9923048 |
| evidence against kshv infection in the pathogenesis of multiple myeloma. | kaposi's sarcoma-associated herpesvirus (kshv) is likely to play a pathogenic role in kaposi's sarcoma, body cavity-based primary effusion lymphoma and a subset of castleman's disease. a recent polymerase chain reaction (pcr)-based study reported an association between kshv and multiple myeloma (mm). we searched for kshv infection in mm patients by serology, pcr and immunohistochemistry. in addition, we cultured dendritic and stromal cells from mm patients. kshv antibodies were universally absen ... | 1998 | 9870587 |
| [importance of tumor banks in hemo-lymphatic pathology]. | 1998 | 9884756 | |
| [new oncogenic viruses in human pathology]. | 1998 | 9884762 | |
| leukapheresis cells of patients with multiple myeloma collected after mobilization with chemotherapy and g-csf do not bear kaposi's sarcoma associated herpesvirus dna. | the presence of kaposi's sarcoma associated herpesvirus (kshv) in bone marrow dendritic cells, in bone marrow biopsies and in dendritic cells of peripheral blood from patients with multiple myeloma (mm) has been reported. these data suggested an association between infection with kshv and the development of mm. the mobilization of infected cells into leukapheresis products (lp) has also been described. we assessed the lp of 35 patients with mm for the presence of kshv using a sensitive and speci ... | 1998 | 9886341 |
| future trends in kaposi's sarcoma and lymphoma. | 1998 | 9874115 | |
| activity of thalidomide in aids-related kaposi's sarcoma and correlation with hhv8 titre. | a phase ii study of thalidomide was conducted to evaluate its efficacy and toxicity in the treatment of cutaneous aids-related kaposi's sarcoma (aids-ks). to evaluate whether clinical response is correlated with titre of human herpesvirus 8 (hhv8) dna in peripheral blood, levels were determined by serial end-point dilution at enrolment and 4-6 weeks later. seventeen male hiv-seropositive patients with histopathologically diagnosed ks were treated with thalidomide 100mg orally once nightly for 8 ... | 1998 | 9874123 |
| the enigmas of kaposi's sarcoma. | 1998 | 9874635 | |
| seroconversion for human herpesvirus 8 during hiv infection is highly predictive of kaposi's sarcoma. | the finding of antibodies against human herpesvirus 8 (hhv-8) is associated with the occurrence of kaposi's sarcoma in persons infected with hiv. however, the predictive value of hhv-8 antibodies for kaposi's sarcoma in hiv infection is unknown. | 1998 | 9875587 |
| [human herpesvirus-8 in hungarian blood donors and in patients with kaposi sarcoma]. | the pathogenic role of kaposi's sarcoma associated herpesvirus or human herpesvirus-8 in the development of kaposi's sarcoma is widely accepted today. here the authors report an indirect immunofluorescence assay based seroepidemiologic study. their results indicate that 1.56% (17/1089) of the hungarian adult population and 100% (12/12) of kaposi's sarcoma patients have serum antibodies to hhv-8 latent nuclear antigens. | 1998 | 9876459 |
| accessibility of selenomethionine proteins by total chemical synthesis: structural studies of human herpesvirus-8 mip-ii. | the determination of high resolution three-dimensional structures by x-ray crystallography or nuclear magnetic resonance (nmr) is a time-consuming process. here we describe an approach to circumvent the cloning and expression of a recombinant protein as well as screening for heavy atom derivatives. the selenomethionine-modified chemokine macrophage inflammatory protein-ii (mip-ii) from human herpesvirus-8 has been produced by total chemical synthesis, crystallized, and characterized by nmr. the ... | 1998 | 9877169 |
| human herpesvirus 8 is not associated with kawasaki disease. | 1998 | 9877378 | |
| reactivation of kaposi's sarcoma-associated herpesvirus infection from latency by expression of the orf 50 transactivator, a homolog of the ebv r protein. | kaposi's sarcoma (ks)-associated herpesvirus (kshv), or human herpesvirus 8, is a lymphotropic virus strongly linked to several aids-related neoplasms. the primary reservoir of infection consists of latently infected b lymphocytes and possibly other mononuclear cells. viral reactivation from latency and spread from this lymphoid reservoir is presumably required for development of nonlymphoid tumors like ks. here we show that deregulated expression of a single viral gene, orf 50, which encodes a ... | 1998 | 9878608 |
| [hhv-8 related diseases]. | kaposi's disease: hhv-8 sequences have been found in all the epidemiological forms of kaposi's disease. there is a direct relationship between hhv-8 infection and pbmc and later development of kaposi's disease. the hhv-8 sequences can be found in spindle cells or endothelial cells in kaposi lesions. other diseases: hhv-8 is also associated with certain lymphomas including body-cavity-based lymphomas and castleman's disease. it has also been put forward that there is a relationship between hhv-8 ... | 1998 | 9879330 |
| sequence analyses of human herpesvirus-8 strains from both african human immunodeficiency virus-negative and -positive childhood endemic kaposi's sarcoma show a close relationship with strains identified in febrile children and high variation in the k1 glycoprotein. | human herpesvirus-8 (hhv-8) dna sequences have been identified in all forms of kaposi's sarcoma (ks), a cancer found primarily in adult aids patients. we have identified hhv-8 strains in a rare human immunodeficiency virus (hiv)-negative form of ks, which is endemic in children in parts of sub-saharan africa. this was shown in zambia, where we also had identified hhv-8 sequences in blood from hiv-negative febrile children without ks. in order to investigate the relationship of these zambian stra ... | 1998 | 9880022 |
| expression of human herpesvirus-8 oncogene and cytokine homologues in an hiv-seronegative patient with multicentric castleman's disease and primary effusion lymphoma. | human herpesvirus-8 (hhv-8) has been described in association with two lymphoproliferative disorders: one benign, multicentric castleman's disease (mcd), and one malignant, primary effusion lymphoma (pel). the factors that lead to malignant transformation of lymphoid cells are unknown, although most cases of pel also are positive for ebv, suggesting a role for ebv as a cofactor in malignant transformation. we encountered a rare case of an hhv-8-associated mcd, followed by the development of an h ... | 1998 | 9881964 |
| new directions in molecular techniques for pathogen identification. | 1998 | 9614340 | |
| transient virus infection and pathogenesis of a new hiv type 2 isolate, uc12, in baboons. | we have previously shown that baboons (papio cynocephalus) can be persistently infected with hiv-2 and some baboons progress to an aids-like disease with a cd4+ t cell decline, cachexia, alopecia, and kaposi's sarcoma-like fibromatosis. in this study, we found that a new virus isolate, hiv-2uc12, replicated to high levels in baboon peripheral blood mononuclear cells (pbmcs) in vitro. three baboons were subsequently inoculated and had plasma viral rna loads that peaked between 15,000 and 7000 cop ... | 1998 | 9453254 |
| clinical-grade functional dendritic cells from patients with multiple myeloma are not infected with kaposi's sarcoma-associated herpesvirus. | bone marrow dendritic cells (dc) from patients with multiple myeloma (mm) were recently reported to be infected with kaposi's sarcoma-associated herpesvirus (kshv). because immunotherapy strategies using dc are very promising in this disease, we looked for kshv dna in clinical-grade dc generated in vitro from mm patients. adherent apheresis cells from mm patients were maintained for 7 days in clinical-grade x-vivo 15 culture medium supplemented with granulocyte-macrophage colony-stimulating fact ... | 1998 | 9490666 |
| human herpesvirus type 8 interleukin-6 homologue is functionally active on human myeloma cells. | seroepidemiology and polymerase chain reaction studies have strongly suggested that human herpesvirus type 8 (hhv-8) is associated with kaposi's sarcoma, castleman's disease, and body cavity-based lymphoma. the genome of hhv-8 harbors a viral analogue of the interleukin-6 (il-6) gene. the amino acid sequence of the viral il-6 (vil-6) protein is 24.7% identical to human il-6 (hil-6). il-6 as a b-cell growth and differentiation factor is known to play an essential role in the pathophysiology of b- ... | 1998 | 9490667 |
| kaposi's sarcoma and human herpesvirus-8. | ks is a major cause of morbidity and mortality among aids patients and a treatment problem in the sporadic cases that are not associated with hiv. all four forms of the disease are linked to a newly described herpesvirus, hhv-8 or kshv, via strong epidemiologic associations and biologic plausibility as a causal agent. hhv-8 is also epidemiologically associated with body cavity-based lymphomas, which are almost unique to aids, and castleman's disease. existing radiation and chemotherapeutic treat ... | 1998 | 9494830 |
| herpes virus type 8-negative primary effusion lymphoma associated with pax-5 gene rearrangement and hepatitis c virus: a case report and review of the literature. | at present, there is no case report of hhv8- primary effusion lymphoma (pel) with t(9;14)(p13;q32) involving both pax-5 and immunoglobulin heavy chain gene rearrangement, which is a rare translocation in b-cell non-hodgkin's lymphoma, in an hiv- patient. we examined an hiv-seronegative 63-year-old japanese man with hepatitis c virus-associated liver cirrhosis and hepatocellular carcinoma manifesting peritoneal lymphomatous effusion without tumor mass at any body site. the lymphoma cells were exa ... | 1998 | 9850179 |
| human herpes virus 8 (hhv-8) in kaposi's sarcoma: lack of association with bcl-2 and p53 protein expression. | human herpes virus 8 (hhv-8) is the infectious agent implicated in the pathogenesis of kaposi's sarcoma, although its mode of action is unclear. recent work indicates that the hhv-8 genome encodes a viral bcl-2 homologue (v-bcl-2). the aim of this study was to explore bcl-2 expression in kaposi's sarcoma using a unique set of hhv-8 positive and negative cases, and to determine whether there is a relation with p53 expression. | 1998 | 9850339 |
| hhv-8 is not associated with follicular dendritic cell tumours. | follicular dendritic cell tumours are rare malignancies derived from the follicular dendritic cells of lymphoid follicles. these tumours have been associated with epstein-barr virus infections and with the hyaline vascular subtype of castleman's disease. because many examples of castleman's disease have been associated with kaposi's sarcoma associated herpes virus (hhv-8), this study uses polymerase chain reaction technology to examine five cases of follicular dendritic cell tumours for hhv-8. o ... | 1998 | 9850342 |
| [hiv-associated lymphoma]. | 1998 | 9851145 | |
| immunological profile of endemic and epidemic kaposi's sarcoma patients in dar-es-salaam, tanzania. | kaposi's sarcoma (ks) presents in four clinicopathological types namely classical/sporadic (cks), endemic african (eks), iatrogenic (iks) and that associated with aids (aks). recently a putative herpes virus (hhv-8) was described and shown to be present in all four types of ks. the immunological status of patients with eks has been conflicting. in this study total leucocyte counts, total lymphocyte counts and lymphocyte subsets of patients with eks and aks were determined by flow cytometry and c ... | 1998 | 9852634 |
| [human herpesvirus 8 ( hhv-8 ): i. characteristics and epidemiology]. | hhv8 is a new herpesvirus recently identified in the kaposi's sarcoma lesions, and initially named kaposi's sarcoma-associated herpesvirus. it is a member of gamma-2 herpesvirus family and it shows a number of homologies with the epstein-barr virus and the herpesvirus saimiri. hhv8 genome also codes for several proteins which are homologous to cellular proteins and could disturb the regulation mechanisms of cellular proliferation and apoptosis. this is the case for a viral il6, an antiapoptotic ... | 1998 | 9853023 |
| lymphangiosarcoma of the pubic region: a rare complication arising in congenital non-hereditary lymphedema. | lymphangiosarcoma is a rare, aggressive, vascular neoplasm arising in chronic congenital or acquired lymphedema. although it is most frequently associated with post-mastectomy lymphedema (stewart-treves's syndrome), lymphangiosarcoma can exceptionally arise in congenital hereditary lymphedema (milroy's syndrome and meige's syndrome) and non-hereditary lymphedema (congenital, praecox or forme tarde lymphedemas). we report a case of lymphangiosarcoma of the pubic region, supported by immunohistoch ... | 1998 | 9854166 |
| the association of skin diseases with human herpesvirus 8 infection in hiv carriers. | the seroprevalence to kaposi's sarcoma-associated herpesvirus (kshv) or human herpesvirus type 8 (hhv-8) was surveyed in human immunodeficiency virus type 1 (hiv-1) carriers with or without skin diseases, and also in hiv-1 negative individuals in thailand. using an immunofluorescence assay, the seropositive rates to lytic antigens of hhv-8 in hiv-1 carriers with or without skin diseases were 25% and 7.4%, respectively, but none of hiv-1 negative individuals had antibody. the seroprevalence to hh ... | 1998 | 9856078 |
| reactivation of behçet's disease in the course of multicentric hhv8-positive castleman's disease: long-term complete remission by a combined chemo/radiation and interferon-alpha therapy regimen. | we used a new combined chemo- (cop/abvd), radiation and interferon-alpha (10 x 10(6) iu s.c. 3x per week/12 months) therapy regimen to treat severe multicentric castleman's disease (cd) complicated by relapsing behcet's disease (bd) manifestations. more than 16 years after diagnosis of cd the patient remains in very good clinical condition, with remission of all cd and bd manifestations 13 months after discontinuation of the interferon-alpha treatment. in addition, our clinicopathological, immun ... | 1998 | 9858232 |
| [prevention of opportunistic infections in the protease inhibitor era]. | from the middle of 1996 we are living a striking reduction of incidence of opportunistic infections (ols) associated to human immunodeficiency virus (hiv). the recovery of the immune system, at least partially, is showing up substantial changes of ols after the introduction of highly active antiretroviral therapy (haart): relieves, sometime complete resolutions, of ols that previously did not give any response to the treatment (cryptosporidiosis, microsporidiosis, progressive multifocal leucoenc ... | 1998 | 9859614 |
| human papillomavirus, epstein-barr virus, human herpesvirus 8 and human cytomegalovirus involvement in salivary gland tumours. | human papillomaviruses (hpv) are involved in the etiology of both benign and malignant epithelial lesions. the occurrence of hpv types 16 and 18 in gynecological squamous cell carcinomas is also well known. of the herpesviruses, epstein-barr virus (ebv) is associated with, for example, undifferentiated nasopharyngeal carcinoma, endemic burkitt's lymphoma and immunoblastic lymphoma, and human herpesvirus 8 (hhv-8) with kaposi's sarcoma. as little is known about the etiological factors of salivary ... | 1998 | 9861347 |
| parenteral transmission of kaposi's sarcoma-associated herpesvirus. | 1998 | 9863879 | |
| role of the interferon regulatory factors (irfs) in virus-mediated signaling and regulation of cell growth. | as a response to viral infection, cells express the early inflammatory genes that encode small proteins generally called cytokines or chemokines. these protein can activate immune responses to viral infection as well as to modulate directly the outcome of viral infection. the group of proteins with the direct antiviral effects have been called interferons. the stimulation of interferon synthesis in infected cells is regulated on a transcriptional level and two families of cellular transcriptiona ... | 1998 | 9865487 |
| the incidence and spectrum of aids-defining illnesses in persons treated with antiretroviral drugs. | the incidence and spectrum of primary aids-defining illnesses in human immunodeficiency virus-positive patients receiving antiretroviral drugs may have changed since the introduction of newer antiretroviral agents. we performed a retrospective analysis of patients enrolled in the british columbia drug treatment program who were ever prescribed antiretroviral drugs between 1 january 1994 and 31 december 1996. rates were calculated on a 6-month basis. there were 344 aids cases diagnosed among 2,53 ... | 1998 | 9868646 |
| primary effusion lymphoma and kaposi's sarcoma in an hiv-infected man. | 1998 | 9819115 | |
| anorectal disease in hiv-infected patients. | anorectal diseases are common in human immunodeficiency virus-infected individuals. the aim of this prospective study was to assess the cause and clinical presentation of anorectal disease in this human immunodeficiency virus-infected population. | 1998 | 9823801 |
| hhv-8 infection is specific for cell lines derived from primary effusion (body cavity-based) lymphomas. | human herpes virus 8 (hhv-8; or kshv, kaposi's sarcoma-associated herpes virus) is a gamma herpes virus with sequence homology to epstein-barr virus (ebv). it was first isolated from kaposi's sarcoma tumor cells and subsequently from tumor cells and peripheral blood mononuclear cells from patients with primary effusion lymphomas (pel; or body cavity-based lymphomas). pel has been recognized as an individual nosologic entity based on its distinctive biological-pathological features and its consis ... | 1998 | 9823957 |