Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| polymerase chain reaction detection of puumala virus rna in formaldehyde-fixed biopsy material. | infections with hantaviruses, mainly clethrionomys-derived puumala viruses, are known causes of acute renal failure [hemorrhagic fever with renal syndrome (hfrs)] in western europe. laboratory diagnosis is primarily based on serology. at the time of clinical symptoms, viral rna can hardly be detected in the blood or urine, indicating that polymerase chain reaction (pcr) is of little diagnostic value for these infections. biopsy material is usually formaldehyde-fixed and, thus, regarded as poor q ... | 1999 | 10231472 |
| relationships of deer mouse movement, vegetative structure, and prevalence of infection with sin nombre virus. | the effects of vegetative structure on movement of deer mice (peromyscus maniculatus) were examined in two distinct vegetation associations, one near hesperus and the other near molina in western colorado (usa) from june-october 1994 to october 1998. we monitored movement by live-trapping small mammals within gambel's oak/mixed-grass (hesperus) and sage brush/juniper (molina) vegetation types. vegetative structure differed between the sites with molina having more cover provided by shrubs and he ... | 1999 | 10231758 |
| emerging infectious diseases and pathogens. | emerging infectious diseases are caused by old, new, and mutant microorganisms. emergence of these pathogens can be attributed to changes in the characteristics and risk factors of patients, the widespread use of antibiotics, changes in the environment, the role of xenotransplantation, and international travel. in the united states, the incidences of c. difficile, cyclosporiasis, enterohemorrhagic e. coli gastroenteritis, hantavirus, hepatitis c virus infection, and lyme disease have increased s ... | 1999 | 10318733 |
| low prevalence of antibodies against the zoonotic agents brucella abortus, leptospira spp., streptococcus suis serotype ii, hantavirus, and lymphocytic choriomeningitis virus among veterinarians and pig farmers in the southern part of the netherlands. | serum samples from 102 veterinarians and 191 pig farmers from the southern part of the netherlands were investigated for antibodies against brucella abortus, leptospira spp, streptococcus suis serotype ii, hantavirus (hv), and lymphocytic choriomeningitis virus (lcmv). all samples were collected in 1993 and stored until this study was performed. the prevalence of antibodies against b.abortus in veterinarians (4.5%) was significantly higher (p = 0.01) than in pig farmers (0%). none of the veterin ... | 1999 | 10321013 |
| dna vaccination with hantavirus m segment elicits neutralizing antibodies and protects against seoul virus infection. | seoul virus (seov) is one of four known hantaviruses causing hemorrhagic fever with renal syndrome (hfrs). candidate naked dna vaccines for hfrs were constructed by subcloning cdna representing the medium (m; encoding the g1 and g2 glycoproteins) or small (s; encoding the nucleocapsid protein) genome segment of seov into the dna expression vector pwrg7077. we vaccinated balb/c mice with three doses of the m or s dna vaccine at 4-week intervals by either gene gun inoculation of the epidermis or n ... | 1999 | 10069952 |
| hantavirus pulmonary syndrome. | we present the first case of hantavirus pulmonary syndrome in the dallas/fort worth area. the patient was a 50-year-old previously healthy white man, who had adult respiratory distress syndrome (ards) and hypotensive shock after 1 week of nonspecific "viral" symptoms. despite supportive care, the patient died within several hours of presentation. this case illustrates several of the classic hallmarks of hantavirus infection such as hemoconcentration, thrombocytopenia, ards, and shock. | 1999 | 10071675 |
| spectrum of hantavirus infection: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. | hantaviruses chronically infect rodents without apparent disease, but when they are spread by aerosolized excreta to humans, two major clinical syndromes result: hemorrhagic fever with renal syndrome (hfrs) and hantavirus pulmonary syndrome (hps). both diseases appear to be immunopathologic, and inflammatory mediators are important in causing the clinical manifestations. in hps, t cells act on heavily infected pulmonary endothelium, and it is suspected that gamma interferon and tumor necrosis fa ... | 1999 | 10073292 |
| isolation and characterization of dobrava hantavirus carried by the striped field mouse (apodemus agrarius) in estonia. | dobrava hantavirus (dob) was isolated from the striped field mouse (apodemus agrarius) trapped on saaremaa island, estonia, and its genetic and antigenic characteristics were subsequently analysed. phylogenetic analysis showed that the estonian dob strain, together with several wild strains carried by apodemus agrarius, forms a well-supported lineage within the dob clade. the topography of the trees calculated for the s, m and l nucleotide sequences of the estonian dob suggests a similar evoluti ... | 1999 | 10073697 |
| emerging viral infections. | 1999 | 10079847 | |
| [acute hantavirus infection caused by a genetically newly identified viral strain. severe and complicated course of hemorrhagic fever with renal syndrome (nephropathia epidemica)]. | a 49-year-old patient, a hobby hunter, fell ill acutely with joint and limb pain, abdominal pain, nausea and subfebrile temperatures. at hospitalization, the patient was in bad general condition, showing ascites and lid edema, and acute renal failure was diagnosed. | 1999 | 10081288 |
| genetic diversity and distribution of peromyscus-borne hantaviruses in north america. | the 1993 outbreak of hantavirus pulmonary syndrome (hps) in the southwestern united states was associated with sin nombre virus, a rodent-borne hantavirus; the virus' primary reservoir is the deer mouse (peromyscus maniculatus). hantavirus-infected rodents were identified in various regions of north america. an extensive nucleotide sequence database of an 139 bp fragment amplified from virus m genomic segments was generated. phylogenetic analysis confirmed that snv-like hantaviruses are widely d ... | 1999 | 10081674 |
| climatic and environmental patterns associated with hantavirus pulmonary syndrome, four corners region, united states. | to investigate climatic, spatial, temporal, and environmental patterns associated with hantavirus pulmonary syndrome (hps) cases in the four corners region, we collected exposure site data for hps cases that occurred in 1993 to 1995. cases clustered seasonally and temporally by biome type and geographic location, and exposure sites were most often found in pinyon-juniper woodlands, grasslands, and great basin desert scrub lands, at elevations of 1,800 m to 2,500 m. environmental factors (e.g., t ... | 1999 | 10081675 |
| long-term studies of hantavirus reservoir populations in the southwestern united states: rationale, potential, and methods. | hantaviruses are rodent-borne zoonotic agents that cause hemorrhagic fever with renal syndrome in asia and europe and hantavirus pulmonary syndrome (hps) in north and south america. the epidemiology of human diseases caused by these viruses is tied to the ecology of the rodent hosts, and effective control and prevention relies on a through understanding of host ecology. after the 1993 hps outbreak in the southwestern united states, the centers for disease control and prevention initiated long-te ... | 1999 | 10081676 |
| long-term hantavirus persistence in rodent populations in central arizona. | for 35 months, we monitored hantavirus activity in rodent populations in central arizona. the most frequently captured hantavirus antibody-positive rodents were peromyscus boylii and p. truei. antibody-positive p. boylii were more frequently male (84%), older, and heavier, and they survived longer on trapping web sites than antibody-negative mice. the number of antibody-positive p. boylii was greater during high population densities than during low densities, while antibody prevalence was greate ... | 1999 | 10081677 |
| a longitudinal study of sin nombre virus prevalence in rodents, southeastern arizona. | we determined the prevalence of sin nombre virus antibodies in small mammals in southeastern arizona. of 1,234 rodents (from 13 species) captured each month from may through december 1995, only mice in the genus peromyscus were seropositive. antibody prevalence was 14.3% in 21 white-footed mice (p. leucopus), 13.3% in 98 brush mice (p. boylii), 0.8% in 118 cactus mice (p. eremicus), and 0% in 2 deer mice (p. maniculatus). most antibody-positive mice were adult male peromyscus captured close to o ... | 1999 | 10081678 |
| statistical sensitivity for detection of spatial and temporal patterns in rodent population densities. | a long-term monitoring program begun 1 year after the epidemic of hantavirus pulmonary syndrome in the u.s. southwest tracked rodent density changes through time and among sites and related these changes to hantavirus infection rates in various small-mammal reservoir species and human disease outbreaks. we assessed the statistical sensitivity of the program's field design and tested for potential biases in population estimates due to unintended deaths of rodents. analyzing data from two sites in ... | 1999 | 10081679 |
| natural history of sin nombre virus in western colorado. | a mark-recapture longitudinal study of immunoglobulin g (igg) antibody to sin nombre virus (snv) in rodent populations in western colorado (1994-results summarized to october 1997) indicates the presence of snv or a closely related hantavirus at two sites. most rodents (principally deer mice, peromyscus maniculatus, and pinyon mice, p. truei) did not persist on the trapping webs much beyond 1 month after first capture. some persisted more than 1 year, which suggests that even a few infected deer ... | 1999 | 10081680 |
| long-term studies of hantavirus reservoir populations in the southwestern united states: a synthesis. | a series of intensive, longitudinal, mark-recapture studies of hantavirus infection dynamics in reservoir populations in the southwestern united states indicates consistent patterns as well as important differences among sites and host-virus associations. all studies found a higher prevalence of infection in older (particularly male) mice; one study associated wounds with seropositivity. these findings are consistent with horizontal transmission and transmission through fighting between adult ma ... | 1999 | 10081681 |
| a midcourse assessment of hantavirus pulmonary syndrome. | 1999 | 10081689 | |
| navigational instinct: a reason not to live trap deer mice in residences. | 1999 | 10081690 | |
| genetic diversities of hantaviruses among rodents in hokkaido, japan and far east russia. | seroepizootiologic surveys among wild rodents were carried out in japan and far east russia in 1995 and 1996. seropositive animals were only identified in clethrionomys rufocanus (23/134) in hokkaido, japan. on the other hand, seropositives were identified in c. rufocanus (1/8), apodemus agrarius (2/66), apodemus spp. (2/26) and microtus fortis (3/22) in vladivostok, far east russia. total rna was isolated from lungs of seropositive animals and the s genome segments were amplified by pcr, cloned ... | 1999 | 10082393 |
| [hantavirus infection]. | 1999 | 10088345 | |
| update on emerging infections from the centers for disease control and prevention. hantavirus pulmonary syndrome--colorado and new mexico, 1998. | 1999 | 9867901 | |
| sin nombre virus pathogenesis in peromyscus maniculatus. | sin nombre virus (snv), a member of the hantavirus genus, causes acute viral pneumonia in humans and is thought to persistently infect mice. the deer mouse, peromyscus maniculatus, has been identified as the primary reservoir host for snv. to understand snv infection of p. maniculatus, we examined wild deer mice for localization of viral antigens and nucleic acid. morphologic examination consistently revealed septal edema within lung tissue and mononuclear cell infiltrates in portal areas of the ... | 1999 | 9847363 |
| recombination in tula hantavirus evolution: analysis of genetic lineages from slovakia. | to examine the evolution of tula hantavirus (tul), carried by the european common vole (microtus arvalis and m. rossiaemeridionalis), we have analyzed genetic variants from slovakia, the country where the virus is endemic. phylogenetic analysis (phylip) based on either partial (nucleotides [nt] 441 to 898) or complete n-protein-encoding sequences divided slovakian tul variants into two main lineages: (i) strains from eastern slovakia, which clustered with russian strains, and (ii) strains from w ... | 1999 | 9847372 |
| new york 1 and sin nombre viruses are serotypically distinct viruses associated with hantavirus pulmonary syndrome. | new york 1 virus (ny-1) and sin nombre virus (sn) are associated with hantavirus pulmonary syndrome (hps). ny-1 and sn are derived from unique mammalian hosts and geographic locations but have similar g1 and g2 surface proteins (93 and 97% identical, respectively). focus reduction neutralization assays were used to define the serotypic relationship between ny-1 and sn. sera from ny-1-positive peromyscus leucopus neutralized ny-1 and sn at titers of >/=1/3,200 and </=1/400, respectively (n = 12). ... | 1999 | 9854075 |
| [hantavirus in chile: review and cases analysis since 1975]. | since the identification of the first case of hantavirus infection in chile in 1995, a great advance in the knowledge of the disease natural history has occurred. there is evidence to suppose that the infection by andes virus in suburban areas of argentina and chile, whose natural reservoir is oligoryzomys longicaudatus, has been present but unidentified for a long time. we describe a serologically proven case occurred in 1975. the clinical presentation of the disease slightly differs from that ... | 1999 | 10835761 |
| [topics of emerging, re-emerging infectious diseases]. | 1999 | 10866500 | |
| [an epidemiological analysis of hemorrhagic fever with renal syndrome morbidity in the republic of bashkortostan in 1997]. | the outbreak of hemorrhagic fever with renal syndrome (hfrs) in the republic of bashkortostan, resulting in 10,057 registered cases of the disease (287 cases per 100,000 of the population), was analyzed. hfrs cases among the population were registered in 52 out of 54 regions of bashkortostan. 31% of the total number of patients were the inhabitants of rural regions (170 cases per 100,000) and 69% were urban dwellers (295 cases per 100,000), mainly in ufa (512 cases per 100,000). hfrs morbidity a ... | 1999 | 10876849 |
| hantavirus (bunyaviridae) infections in rodents from orange and san diego counties, california. | 1999 | 10674658 | |
| hantavirus infections in rodents | 1999 | 10674659 | |
| hantavirus dobrava infection with pulmonary manifestation. | dobrava virus infection was diagnosed serologically by enzyme-linked immunosorbent and immunofluorescence assays. to determine which hantavirus serotype was involved, sera were analyzed by a focus reduction neutralization test. the clinical data indicated that only pulmonary manifestation was present. our data support the presence of dobrava virus infection outside the balkan region. in conclusion, a previously healthy adult with unexplained pulmonary perfusion failure should be investigated for ... | 1999 | 10691093 |
| a case-control study after a hantavirus infection outbreak in the south of belgium: who is at risk? | puumala is the most common hantavirus serotype in europe and is spread mainly by the red bank vole. between 1 july 1992 and 31 january 1994, an outbreak of puumala virus-induced nephropathia epidemica (ne) occurred in the belgian ardennes. serologically confirmed cases (n = 41) were compared with two groups of asymptomatic seronegative controls. risks identified included sighting of living rodents, exposure to rodent droppings, and trapping rodents during the 4 weeks preceding onset of symptoms. ... | 1999 | 10825047 |
| hemorrhagic fever with renal syndrome in the dolenjska region of slovenia--a 10-year survey. | this report describes the first investigation of clinical findings for a larger series of patients with hemorrhagic fever with renal syndrome (hfrs) who were infected with dobrava virus. from 1985 to 1995, 38 patients with serologically confirmed hfrs were hospitalized at the regional hospital in novo mesto in the dolenjska region of slovenia. on the basis of results of serological examination, 24 patients had dobrava virus infection, and 14 patients had puumala virus infection. complete clinica ... | 1999 | 10825051 |
| [baculovirus: an example of an insect virus of use to humans]. | baculovirus is a viral pathogen of insects in general and lepidoptera in particular. the genome of this large virus consists of a circular, infectious bicatenary dna molecule. at the end of its replication cycle in insects, baculovirus produces a large quantity of at least two proteins, i.e., polyedrine and polypeptide p10. these proteins are essential for transmission of the virus in nature, but are not necessary in cell cultures. using molecular recombinant techniques, one or both of the genes ... | 1999 | 10901857 |
| urban leptospirosis versus urban hantavirus infection in brazil. | 1999 | 10622333 | |
| chronic renal failure after puumala virus infection. | chronic renal failure has never been described after puumala hantavirus infection, which usually causes acute renal failure with spontaneous full recovery. we report a 15-year-old boy who presented with puumala hantavirus infection and initial severe acute renal failure. his renal function gradually improved, but more than 2 years after the acute episode it was still moderately impaired, with a creatinine clearance of about 60 ml/min per 1.73 m(2) | 1999 | 10603154 |
| hantavirus reservoir hosts associated with peridomestic habitats in argentina. | five species of sigmodontine rodents have been identified in argentina as the putative reservoirs of six circulating hantavirus genotypes. two species of oligoryzomys are associated with the genotypes causing hantavirus pulmonary syndrome, oligoryzomys flavescens for lechiguanas and o. longicaudatus for andes and oran genotypes. reports of human cases of hantavirus pulmonary syndrome prompted rodent trapping (2,299 rodents of 32 species during 27,780 trap nights) at potential exposure sites in t ... | 1999 | 10603213 |
| seroprevalence study of hantavirus infection in the community based population. | the genus hantavirus, family bunyaviridae, comprise at least 20 distinct viruses. ten of these have been linked to specific human diseases. hemorrhagic fever with renal syndrome has been recognized since the 1950s. hantavirus pulmonary syndrome was recognized in the united states in 1993. epizootiologic studies of norway rats in the baltimore area have shown that rodent infections with hantaviruses are common and geographically widespread with prevalence reaching 44% in tested rat populations. t ... | 1999 | 10628132 |
| rapidly evolving adult respiratory distress syndrome with eosinophilia of unknown cause in previously healthy active duty soldiers at an army training center: report of two cases. | two previously healthy soldiers presented with rapidly evolving adult respiratory distress syndrome (ards) within days of their return from the national training center at fort irwin, california. there have been six similar cases reported in the national training center area, five with fatal outcomes. | 1999 | 10628168 |
| newer pediatric pathogens. | newer laboratory techniques have allowed the detection of previously unrecognized microbial agents that are now pathogenic in children, as well as newly recognized manifestations of previously known pathogens. clinical reports of these newer agents or manifestations are reviewed so that pediatricians can become familiar with these emerging infectious diseases. physicians need to consider these organisms in the differential diagnosis in appropriate clinical illnesses. | 1999 | 10645465 |
| [hantavirus infections in belgium]. | hantavirus disease is a recently recognised zoonosis. the main vectors are infected but healthy wild rodents or laboratory rats. transmission to man occurs via contact with, or inhalation of aerosolised excretions. the target organs in man are the kidney (old world) or the lung (new world), probably via a local hyperproduction of pro-inflammatory cytokines. to date, more than 33 different hantaviruses have been characterised, at least 14 of them being of clinical importance. each serotype has it ... | 1999 | 10655777 |
| dynamics of puumala hantavirus infection in naturally infected bank voles (clethrinomys glareolus). | specific features of hantavirus infection in bank vole (clethrionomys glareolus) were studied in the endemic area of hemorrhagic fever with renal syndrome (hfrs) in the foothills of the ural mountains, using long-term observations on living animals by the capture-mark-recapture (cmr) method. the results demonstrated that the infection naturally circulating in the voles is chronic (lasting for up to 15 months) and asymptomatic, with a peak of puumala virus accumulation and release from the organi ... | 1999 | 10664394 |
| intravenous ribavirin for hantavirus pulmonary syndrome: safety and tolerance during 1 year of open-label experience. ribavirin study group. | intravenous ribavirin was provided non-selectively for investigational open-label use among persons with suspected hantavirus pulmonary syndrome (hps) in the united states between 4 june 1993 and 1 september 1994. therapy was initiated prior to laboratory confirmation of hantavirus infection because most deaths from hps occur within 48 h of hospitalization. thirty patients with confirmed hps, 105 patients without hps and 5 patients without adequate diagnostic testing for hps were enrolled. this ... | 1999 | 10723500 |
| superovulation in vesper mice, calomys laucha--an important biomedical model for hantavirus and arenavirus (rodentia-sigmodontinae). | sigmodontine rodents are poorly studied and have not received much attention as a reproductive model. renewed interest in the south american rodents has been stimulated by their link to endemic diseases that are transmitted to man. calomys laucha acts as a reservoir of two dangerous viruses: an arenavirus named 'junin virus', the aetiological agent of argentinian haemorrhagic fever, and the hantavirus, both of which constitute serious sanitary problems. the aim of this study was to establish sui ... | 1999 | 10778786 |
| hantavirus pulmonary syndrome: an alert to latin american countries. | approximately 400 cases of hantavirus pulmonary syndrome (hps) have been reported on the north american continent since the first epidemic in 1993, in new mexico, usa. in brazil, 12 cases were confirmed before 1998. infection results from inhalation of rodent blood, saliva or waste. clinical findings of the disease are characterized by a nonspecific febrile illness, followed by rapid progression to pulmonary edema which may lead to a shock-like state or renal failure. mortality is high and emerg ... | 1999 | 11084670 |
| epidemiological progresses of hemorrhagic fever with renal syndrome in china. | to summarize the major achievements of chinese work on the epidemiology and prevention of hemorrhagic fever with renal syndrome (hfrs) in recent years, and to give a general review on the present situation of hfrs in china. | 1999 | 11593522 |
| [the pathogenicity of hfrs patient's soft palate mucosa to suckling mice]. | to explore the pathogenic mechanism of hemorrhagic fever with renal syndrome(hfrs). | 1999 | 12759963 |
| hantavirus pulmonary syndrome in the americas: the early years. | the initial recognition of hantavirus pulmonary syndrome (hps) as a new disease associated with a cluster of acute respiratory deaths among american indians in the southwestern united states in 1993 bears little resemblance to the current understanding of this syndrome. hps is now recognized as a zoonotic disease that has been endemic throughout the americas for at least 40 years and that is closely linked to population densities and virus dynamics among a specific subfamily of rodents. the clas ... | 2000 | 16088742 |
| [detection for anti-hantavirus igm in patient serum with silver enhanced dot immunogold filtration assay]. | to establish a more rapid and simple method for detecting anti-hantavirus igm in patient' s serum. | 2000 | 11498694 |
| [the partial nucleotide sequence of l segment of hantavirus strain]. | to study the nucleotide sequence of l segment of hantavirus strain a9. | 2000 | 11503036 |
| hantavirus update on an emerging--and lethal--infectious disease. | 2000 | 11503410 | |
| [microbiological surveillance: viral hemorrhagic fever in central african republic: current serological data in man]. | an investigation was conducted between 1994 and 1997 in forested areas of the central african republic (car) to determine the seroprevalence of igg antibodies against several haemorrhagic fever viruses present in the region. sera were obtained from 1762 individuals in two groups (pygmy and bantu locuted populations) living in 4 forested areas in the south of the country. sera were tested for igg antibodies against ebola, marburg, rift valley fever (rvf), yellow fever (yf) and hantaviruses by enz ... | 2000 | 11775321 |
| [nephropathia epidemica and other hanta virus infections: how rodents' viruses cause disease in human?]. | 2000 | 11764460 | |
| [study on the genetic difference of seo type hantaviruses]. | to understand the genetic type of hantaviruses and the difference between them caused by rodents in beijing and to furhter explore the source of the infectious factors. | 2000 | 11860814 |
| [safety and immunogenicity of inactivated bivalent ehf vaccine in humans]. | safety and immunogenicity of inactivated bivalent ehf vaccine in humans were evaluated in the epidemic area of zhejiang province, china. | 2000 | 11860832 |
| molecular evolution of puumala hantavirus in fennoscandia: phylogenetic analysis of strains from two recolonization routes, karelia and denmark. | like other members of the genus hantavirus: in the family bunyaviridae:, puumala virus (puuv) is thought to be co-evolving with its natural host, the bank vole clethrionomys glareolus. to gain insight into the evolutionary history of puuv in northern europe during the last post-glacial period, we have studied wild-type puuv strains originating from areas along two postulated immigration routes of bank voles to fennoscandia. full-length sequences of the s rna segment and partial sequences (nt 216 ... | 2000 | 11086113 |
| effects of tumor necrosis factor alpha on sin nombre virus infection in vitro. | previous data indicate that immune mechanisms may be involved in developing capillary leakage during sin nombre virus (snv) infection. therefore, we investigated production of tumor necrosis factor alpha (tnf-alpha) by human alveolar macrophages and human umbilical vein endothelial cells (huvec) after infection with snv. in addition, we examined the effect of tnf-alpha on huvec monolayer leakage. our results reveal that although tnf-alpha decreases accumulation of viral nucleoproteins, tnf-alpha ... | 2000 | 11090198 |
| [use of kinetic hemagglutination inhibition test in study of antigenic relationships of hantavirus strains circulating in foci of hemorrhagic fever with renal syndrome in southern far east of russia]. | the kinetics of reaction between hemagglutinating antigens and immune sera to 10 hantavirus strains (7 isolated in the primorye territory and 3 in other regions) was studied in the cross kinetic hemagglutination inhibition (khai) test. an a parameter is suggested for evaluation of the similarity and differences between the studied strains. this parameter helped detect antigenic differences between hantaan and seoul viruses and the inter-type differences between hantaan-like strains. khai is more ... | 2000 | 11107654 |
| [zoonoses among immigrants]. | during the last ten years denmark has received an increasing number of immigrants, especially from the balkans, the middle east, and somalia. some of these may suffer from the zoonoses occurring in their country of origin. but apart from echinococcosis, zoonoses in these immigrants do not seem to pose a quantitatively greater problem than in danes who have visited these areas. however it is important to have a knowledge of the symptoms and mode of transmission of zoonoses occurring in areas wher ... | 2000 | 11107966 |
| hantavirus infections among mammalogists studied by focus reduction neutralisation test. | 2000 | 11117649 | |
| genetic diversity of hantaviruses isolated in china and characterization of novel hantaviruses isolated from niviventer confucianus and rattus rattus. | the antigenic and genetic properties of 46 hantaviruses from china, 13 from patients, 23 from rodents, and 10 from unknown hosts, were compared with those of other hantaviruses. the viruses were classified as either hantaan (htn) or seoul (seo) viruses. a phylogenetic analysis of the partial m (300 bp) and s (around 485 bp) genomes of htn viruses identified nine distinct genetic subtypes, one consisting of isolates from korea. the seo viruses were divided into five genetic subtypes, although the ... | 2000 | 11118357 |
| expression of a human, neutralizing monoclonal antibody specific to puumala virus g2-protein in stably-transformed insect cells. | we cloned the heavy- and light-chain antibody genes of a human x (humanxmouse) trioma secreting a neutralizing, igg monoclonal antibody to the g2-protein of puumala virus. the antibody genes were inserted separately into plasmid transfer vector piei-4 such that the genes were under control of the baculovirus immediate early gene promoter, iei. trichoplusia ni (tn) cells were co-transfected with these constructs and a selection plasmid containing a neomycin-resistance gene. cloned transformants e ... | 2000 | 11121551 |
| hantavirus pulmonary syndrome is distinguishable from acute interstitial pneumonia. | hantavirus pulmonary syndrome (hps) and acute interstitial pneumonia (aip) can share similar clinical presentations. aip is an acute, diffuse lung disease that has some clinical features suggesting a viral infection, although causative agent(s) have not been identified. | 2000 | 11035576 |
| emerging viral diseases. | 2000 | 11035785 | |
| puumala (puu) hantavirus strain differences and insertion positions in the hepatitis b virus core antigen influence b-cell immunogenicity and protective potential of core-derived particles. | hepatitis b virus (hbv) core-derived chimeric particles carrying a puumala (puu) hantavirus (strain vranica/hällnäs) nucleocapsid (n) protein sequence (aa 1-45), alternatively inserted at three distinct positions (n-, c-terminus, or the internal region), and mosaic particles consisting of hbv core as well as core/puu (vranica/hällnäs) n (aa 1-45) readthrough protein were generated. chimeric particles carrying the insert at the n-terminus or the internal region of core induced some protective imm ... | 2000 | 11040127 |
| [hantavirus disease during pregnancy]. | hantavirus infection is known to occur in mice and rats without symptoms. in contrast, an infection with hantavirus in humans gives influenzalike symptoms and acute renal failure. the treatment is symptomatic, but treatment with dialysis can be necessary for a while. a case of hantavirus infection in denmark in a 30 week pregnant woman is reported. | 2000 | 11043050 |
| hantavirus pulmonary syndrome in northern alberta, canada: clinical and laboratory findings for 19 cases. | we reviewed the clinical and laboratory findings for 19 cases of hantavirus pulmonary syndrome (hps) identified either serologically or by immunohistochemical testing of archival tissue at our tertiary care center. fever (95%), cough (89%), and dyspnea (89%) were the most common presenting symptoms. the most prevalent presenting signs were respiratory abnormalities (95%) and tachycardia (84%). common laboratory findings included thrombocytopenia (95%) and leukocytosis (79%). elevated aspartate a ... | 2000 | 11049774 |
| [hantavirus pulmonary syndrome in southern argentina]. | andes virus was identified in 1995 as the etiologic agent of hantavirus pulmonary syndrome (hps) in southern argentina. we describe herein the main clinical characteristics of 25 hps confirmed cases acquired in this area between 1993 and september 1999. the mean age was 34 years (range 11-70), with 72% males. clinical characteristics were similar to those previously reported for sin nombre virus (snv) cases. however, in this group of patients we also observed conjuntival injection in 10/25 (42%) ... | 2000 | 11050803 |
| [prevalence of anti-hantavirus antibodies in health care personnel in direct contact with patients with hantavirus pulmonary syndrome in temuco, chile 1997 to 1999]. | an outbreak of hantavirus cardiopulmonary syndrome (hvcs) caused by the andes virus, affected chile since 1995. antibodies to hantavirus in health care workers who had cared patients with hvcs in coybaique, argentinean reports and familial clustering of bantaviral illness, raised the possibility of person to person transmission. familial clustering could occur secondary to a similar exposure to a common infected environment of more than one member of the family. moreover, the prevalence of antib ... | 2000 | 11050834 |
| hantavirus pulmonary syndrome in panama: identification of novel hantaviruses and their likely reservoirs. | hantavirus pulmonary syndrome (hps), a severe respiratory disease with high mortality caused by rodent-borne hantaviruses, has previously been identified in the united states and canada as well as central and southern south america. in late 1999 and early 2000, an outbreak of acute illness compatible with hps was reported in los santos, panama, with the death of 3 of the 12 (25%) suspected cases. hantavirus-specific antibodies were detected in patient sera, and virus rna was detected by reverse ... | 2000 | 11062031 |
| first case of puumala virus infection in greece. | 2000 | 11073146 | |
| genetic diversity of hantaviruses associated with hemorrhagic fever with renal syndrome in the far east of russia. | to identify the hantaviruses causing hemorrhagic fever with renal syndrome (hfrs) in the far east of russia, blood samples collected from hfrs patients in 1994-1998, were examined by reverse transcription-polymerase chain reaction. in addition, 36 sera were tested by an immunofluorescence assay for antibodies against hantaan, seoul, puumala, and khabarovsk viruses, and 54 samples were tested by plaque reduction neutralization test. with both serological assays, the highest antibody titers were t ... | 2000 | 11074123 |
| hantavirus pulmonary syndrome associated with monongahela virus, pennsylvania. | the first two recognized cases of rapidly fatal hantavirus pulmonary syndrome in pennsylvania occurred within an 8-month period in 1997. illness in the two patients was confirmed by immunohistochemical techniques on autopsy material. reverse transcription-polymerase chain reaction analysis of tissue from one patient and environmentally associated peromyscus leucopus (white-footed mouse) identified the monongahela virus variant. physicians should be vigilant for such monongahela virus-associated ... | 2000 | 11076720 |
| preliminary characterization and natural history of hantaviruses in rodents in northern greece. | 2000 | 11076727 | |
| evidence of puumala hantavirus infection in red foxes (vulpes vulpes) in belgium. | 2000 | 11083049 | |
| [febrile cytolysis disclosing hemorrhagic fever with renal syndrome]. | we report the case of a 40-year-old-man who developed febrile cytolysis as the presenting sign of hemorragic fever with renal syndrome (hfrs). on admission, he had fever (40 degrees c) and epigastric pain. the ast level was at 2n, the alt at 3n. there was a thrombocytopenia (61 000/mm(3)) without anemia or hyperleukocytosis. three days after admission, the platelet count decreased to 40 000/mm(3), serum urea and creatinine increased from normal rate to 10.8mmol/l, 204.0 micromol/l, respectively. ... | 2000 | 11173712 |
| hantavirus infections. | hantaviruses are the causative agents of the zoonotic diseases known as haemorrhagic fever with renal syndrome (hfrs) in europe and asia, and hantavirus pulmonary syndrome (hps) in the americas. these pathogens are maintained in the wild by rodent reservoirs and are mainly transmitted via the aerosol route. the infection is chronic and apparently asymptomatic in host animals. whilst hfrs is caused by hantaan, seoul, dobrava and puumala hantaviruses, hps is associated with sin nombre-like viruses ... | 2000 | 11189727 |
| puumala and dobrava hantaviruses causing hemorrhagic fever with renal syndrome in estonia. | 2000 | 11205639 | |
| [adaptive property of hantaviruses during their isolation from cultured vero-e6 cells in relation to the type of the ecological host]. | as a result of virological studies, 185 lung tissue specimens from 4 rodent species caught near khabarovsk were isolated and fixed in the passages of cultured vero-6 cells of 68 hantavirus strains. the capacity of the strains to adapt to the cells was assessed by using the adaptive index involving the mean rates of successful isolation, its duration, hantavirus antigen titer in the material used for infection. the strains of hantavirus serotypes were noted for the highest adaptive properties, wh ... | 2000 | 11210409 |
| new and emerging pathogens. | 2000 | 11219303 | |
| emerging infectious diseases: a cause for concern. | as the twenty-first century begins it becomes increasingly apparent that the twentieth century, which opened with the promise of the eradication of most infectious diseases, closed with the specter of the reemergence of many deadly infectious diseases that have a rapidly increasing incidence and geographic range. equally if not more alarming is the appearance of new infectious diseases that have become major sources of morbidity and mortality. among recent examples are hiv/aids, hantavirus pulmo ... | 2000 | 11344776 |
| serological study of hantavirus in the rodent population of nakhon pathom and nakhon ratchasima provinces thailand. | a serological survey has been carried out to detect evidence of hantavirus infection in rodents from two provinces of thailand. this study aimed to examine virus antibody in 354 rodents trapped among 6 different villages of nakhon pathom province (february-march, 1998) and in 326 rodents trapped among 14 villages of nakhon ratchasima province (august-october, 1998). seroprevalence among rodents from nakhon pathom province (2.3%), was mostly find in rattus norvegicus (3.8%) and bandicota indica ( ... | 2000 | 11127326 |
| genetic diversity of apodemus agrarius-borne hantaan virus in korea. | hantaan (htn) virus, the etiologic agent of clinically severe hemorrhagic fever with renal syndrome (hfrs), was first isolated in 1976 from lung tissues of striped field mice (apodemus agrarius) captured in songnae-ri, kyungki-do, korea. to clarify the genetic diversity and phylogenetic relationship among korean strains of htn virus, viral sequences of the partial s and m segments were amplified from lung tissues of 24 seropositive striped field mice captured between 1989 and 1998 at 11 sites in ... | 2000 | 11129640 |
| lack of evidence for an association between hantavirus infections and wegener's granulomatosis, microscopic polyangiitis, churg-strauss syndrome and giant cell arteritis. | 2000 | 11136889 | |
| the incubation period of hantavirus pulmonary syndrome. | in 1993 sin nombre virus was recognized as the cause of hantavirus pulmonary syndrome (hps) and the deer mouse (peromyscus maniculatus) was identified as the reservoir host. surveillance by the centers for disease control and prevention and state health departments includes investigation to determine the likely site(s) and activities that led to infection, an environmental assessment of the home and workplace, and possibly rodent trappings at these sites. as of december 31, 1998, there were 200 ... | 2000 | 11304061 |
| [discovery of a new subtype of seo virus]. | the m and s segments of cou3, a hantavirus strain isolated from rattus norvegieus were partially reverse transcripted, pcr amplified and sequenced with abi 373 dna sequencer to observe the differences from other seo type viruses. | 2000 | 11471015 |
| epidemiology of community-acquired pneumonia in adults: a population-based study. | in this prospective study, the authors assessed the incidence, aetiology, and outcome of patients with community-acquired pneumonia in the general population. from december 1993 to november 1995, a study was performed in a mixed residential-industrial urban population of the "maresme" region in barcelona, spain. all subjects > or =14 yrs of age (annual average population size 74,368 inhabitants) with clinically suspected community-acquired pneumonia were registered. all cases were re-evaluated b ... | 2000 | 10780770 |
| genetic analysis of sin nombre hantavirus in iowa. | 2000 | 10783030 | |
| antigenic properties and diagnostic potential of recombinant dobrava virus nucleocapsid protein. | dobrava hantavirus (dobv) causes severe hemorrhagic fever with renal syndrome in the balkan region and has been detected recently also in russia, estonia, and germany. dobv nucleocapsid protein (n) was produced in insect cells, using the baculovirus expression system (bac-dobv-n), and in e. coli as a truncated (aa 1-165) glutathione-s transferase fusion protein (dobv-dn-gst). the antigenic properties of bac-dobv-n were found identical to native dobv-n when examined by a panel of hantavirus-speci ... | 2000 | 10797384 |
| [epidemiologic problems in hantavirus infections]. | the objective of the submitted paper was to present some information pertaining to epidemiological problems of hantavirus infection. in the czech republic the prevalence of these infections is not alarming but in the world cases of haemorrhagic fever with renal syndrome (hfrs) as well as hantavirus pulmonary syndrome (hps) are reported. on the territory of the czech republic there are foci of hantaviruses and in conjunction with summer tourism or working activities abroad the import of this infe ... | 2000 | 10802945 |
| from the centers for disease control and prevention. hantavirus pulmonary syndrome--panama, 1999-2000. | 2000 | 10807372 | |
| [acute renal failure in hantavirus infections]. | background: the acute renal failure remains a diagnostic challenge for the clinician. case reports: between 1991 and 1996, acute renal failure caused by hantavirus infection was diagnosed in 4 previously healthy male patients. main symptoms consisted of fever, headache, arthralgia, lumbar and abdominal pain as well as a decline in diuresis. the ultrasonography showed a slight splenomegaly in 2 patients. the clinical chemistry showed elevated serum creatinine from 2.2 mg/dl to 6.7 mg/dl and throm ... | 2000 | 10808304 |
| immunoglobulin a responses to puumala hantavirus. | puumala hantavirus (puuv) causes nephropathia epidemica (ne), a form of haemorrhagic fever with renal syndrome that occurs in northern and central europe. the immunoglobulin a (iga) response in ne patients was studied. the levels of total serum iga in acute-phase samples from ne patients were found to be significantly elevated when compared with the levels in healthy controls. elisas for detection of the iga1 and iga2 responses against each puuv structural protein (n, g1 and g2) were developed a ... | 2000 | 10811929 |
| outbreak of hantavirus infection in the four corners region of the united states in the wake of the 1997-1998 el nino-southern oscillation. | hantavirus cardiopulmonary syndrome (hcps), a rodent-borne zoonosis, has been endemic in the americas for at least several decades. it is hypothesized that the 1991-1992 el niño-southern oscillation (enso) caused increased precipitation that allowed an increase in rodent population densities, thereby increasing the possibility of transmission to humans. the result was a 1993-1994 outbreak of the disease in the four corners states of the southwestern united states. a second strong enso occurred i ... | 2000 | 10823755 |
| seroepidemiology of hantavirus in the philippines. | this study was undertaken to determine the seroepidemiology of hantavirus infection in the philippines. | 2000 | 10737848 |
| rodent-borne emerging viral zoonosis. hemorrhagic fevers and hantavirus infections in south america. | hantaviruses and arenaviruses are naturally occurring viruses of rodents. four south american hemorrhagic fevers caused by arenaviruses have emerged in the last 5 decades. all have similar clinical manifestations, with a case-fatality rate as high as 15% to 30%. hantavirus infections have been increasingly recognized in south america since the description in 1993 of hantavirus pulmonary syndrome. given the diversity of rodent species in the region, it can be foreseen that many other viruses will ... | 2000 | 10738678 |
| hantavirus pulmonary syndrome--panama, 1999-2000. | hantavirus pulmonary syndrome (hps) is an acute viral rodentborne zoonosis characterized by severe cardiopulmonary illness with a 40%-60% case-fatality rate. since its identification in the united states in 1993, the recognized clinical spectrum of illnesses associated with human hantavirus infection has expanded to include mild illness, and case-patients have been identified in canada and south america. this report describes the first confirmed hps cases from central america and summarizes prel ... | 2000 | 10738839 |
| [serologic study of the prevalence and course of hantavirus infections in mecklenburg-vorpommern]. | 694 sera obtained from 1994 till 1998 in the general population were examined with a recombinant enzyme immunoassay for hantavirus antibodies against the serotypes hantaan and puumala. positive samples were retested for confirmation with an indirect immunofluorescence assay and a recombinant immunoblot. the observed antibody prevalence of 0.9% signities that mecklenburg-vorpommern is not an endemic area. 12 out of 196 patients with a suspected hantavirus infection were confirmed. all proved anti ... | 2000 | 10740354 |
| hantavirus pulmonary syndrome in brazil: clinical aspects of three new cases. | hantavirus pulmonary syndrome (hps) has been recognized recently in brazil, where 28 cases have been reported as of september 1999. we report here the clinical and laboratory findings of three cases whose diagnoses were confirmed serologically. all the patients were adults who presented a febrile illness with respiratory symptoms that progressed to respiratory failure that required artificial ventilation in two of them. laboratory findings were most of the time consistent with those reported in ... | 2000 | 10742726 |