Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [5 cases of imported malaria]. | 1978 | 358306 | |
| the malaria burden and population growth in the solomon islands. | this paper outlines the result of the control of infectious diseases, and more especially malaria, on the growth of populations in the solomon islands since 1931, the year of the first census, to 1976, the year in which the fourth census revealed, that a population explosion had occurred, and was occurring unabated. | 1978 | 358655 |
| malaria and pregnancy. | a review of current literature on the effects of malaria on pregnant women and the foetus is made and its effective control is discussed. the role of placenta as an exchange organ and as the first defence line for foetus is also described. reduced resistance to malaria during pregnancy may be due to immunological and hormonal changes. in malarious areas, the effective control of malaria results in reduced maternal anaemia and in increased birth-weights. prophylaxis, treatment and other antimalar ... | 1978 | 358656 |
| acute pulmonary edema in plasmodium falciparum malaria. | this report describes a patient who developed acute pulmonary edema as a complication of plasmodium falciparum malaria. hemodynamic evaluation revealed a pulmonary artery wedge pressure of 3 mm hg and a cardiac index of 4.6 liter per min per m2. the patient exhibited an acute decrease in serum colloid osmotic pressure from 25.1 mm hg to 16.8 mm hg. these findings suggest that pulmonary edema in this patient was the result of altered capillary membrane permeability. | 1978 | 358880 |
| malumfashi endemic diseases research project. ii. malariometry in malumfashi, northern nigeria. | prior to longitudinal studies into the effects of malaria upon the immune response, nutritional status and haematological indices in young children in northern nigeria, the degree of malarial endemicity in the area has been established. field work was carried out in the wet seasons of 1976 and 1977 and the dry season of 1977 (april). seasonal variation in transmission has been demonstrated. age-specific parasite prevalence rates and splenic indices confirm previous studies that this northern par ... | 1978 | 358930 |
| haemostatic defect in non-immune patients with falciparum malaria: no evidence of diffuse intravascular coagulation. | nine non-immune patients with imported falciparum malaria were examined for signs of diffuse intravascular coagulation (dic). although all had thrombocytopenia initially and some later had a decline in plasma fibrinogen concentrations, dic was never detected, even in severely affected patients with coma and kidney damage. none of the patients were given heparin and all recovered without residual symptoms. heparin administration should probably be considered only when clear-cut dic, which possibl ... | 1978 | 359086 |
| relative chloroquine resistance. | 1978 | 359093 | |
| intravascular coagulation in falciparum malaria. | 1978 | 359097 | |
| [autopsy case of plasmodium falciparum malaria]. | 1978 | 372631 | |
| clearance of falciparum parasitaemia with a single dose sulfadoxine-pyrimethamine in vientiane, laos. | a total of 49 semi-immune laotians aged 3 to 49 years, with falciparum malaria were treated with a single dose of sulfadoxine pyrimethamine (1500 mg, 75 mg, adult dose), in vientiane, laos. on day 7 after treatment the 49 cases were asymptomatic with complete disappearance of patent asexual parasitaemia. the result is compared with that obtained from treating 48 similar cases with a standard dose of chloroquine over 3 days. | 1978 | 373131 |
| [malaria caused by accidental inoculation. 1 case]. | the authors report a case of direct infection of a nurse who had taken blood sample from a young patient suffering from malaria due to plasmodium falciparum. six similar observations have been reported in the literature. in addition, accidental infection has been observed following the use of non sterile syringes. as a result, malaria could be an unexpected consequence of the drug habit. | 1978 | 369732 |
| chemoprophylaxis and malaria in american servicemen returning from vietnam. | information relating to chemoprophylaxis and malaria in 49 men who served with the united states armed forces in vietnam and who developed overt malaria after departure from vietnam indicated that: 1) compliance with intended chemoprophylactic regimens was far optimal; 2) a history of recent prophylactic ingestion of chloroquine was not a reliable indicator of infection with chloroquine-resistant plasmodium falciparum: 3) reported ingestion of half or more of an intended terminal chemoprophylact ... | 1978 | 343607 |
| plasmodium falciparum: responses of a semi-immune individual to homologous and heterologous challenges, and non-infectivity of gametocytes in anopheles stephensi. | with strict adherence to ethical guidelines, a semi-immune volunteer was exposed to homologous and heterologous blood challenges with strains of plasmodium falciparum from vietnam and tanzania. on both occasions infections developed, but clinical manifestations were moderated, prepatent periods increased, and parasitemias limited. gametocytes produced by these infections failed to infect anopheles stephensi. possible reasons for this are discussed. | 1978 | 343609 |
| [acute renal insufficiency caused by plasmodium falciparum malaria in the last period of pregnancy (2 cases) (author's transl)]. | a report of 2 cases of acute renal insufficiency in african women, 8 months pregnant and suffering of malignant malaria. in both cases labor has been induced by artificial breaking of the membranes and use of oxytocin. one of the children was still-born and the other died 3 days later. delivery has been followed by a resumption of the urinary flow, facilitated by high dosages of furosemide. this diuretic drug when associated with hypoprotidic diet, hypercaloric intravenous infusions of glucose h ... | 1978 | 364241 |
| [the question of endemic malaria in republic of djibouti (author's transl)]. | since 1973 autochthonous cases of malaria due to p. falciparum have been reported among local population of french afars and issas territory; 191 cases observed between 1973 and 1976 are recorded. their monthly distribution and geographical repartition are studied, jointly with the distribution of a. gambiae which has been recently collected in the territory. this study shows a significant correspondance between the presence of a. gambiae and the malaria cases observed which did not come from ne ... | 1978 | 364244 |
| [control of malaria and its eradication in the socialist republic of vietnam]. | 1978 | 364292 | |
| trends in the development of chemotherapy for parasitic diseases. | 1978 | 364672 | |
| human parasitoses of the malili area, south sulawesi (celebes) province, indonesia. | a biomedical survey was conducted in 9 villages in the malili area of south sulawesi, indonesia. blood specimens were examined for malaria and microfilariae; stool specimens were examined for intestinal parasites. malaria parasitemias were rare; plasmodium falciparum was detected in 10 and p. vivax in 11 of 985 blood smears. malayan filariasis was endemic to all villages surveyed. the overall prevalence of detectable microfilaremias was 15%, varying from 34% in kawata to 1% in nuha. microfilaria ... | 1978 | 364674 |
| standardization of the indirect fluorescent antibody test for malaria. | methods are described whereby results of malarial immunofluorescence tests can be evaluated objectively. the ifa test was quantitated by standardizing the physical system against a fluorescent standard and preparation of biological standards of malarial antisera and fluorescein labelled conjugates. using these known standards the reactivity of antigens was characterized. it was found that antigen preparations are best when they include mature schizonts, and keep best when they are stored in a dr ... | 1978 | 364783 |
| detection and measurement of species-specific malarial antibodies by immunofluorescence tests. | species-specific serodiagnosis of malaria could be made by means of the standardized indirect fluorescent antibody test, either by determination of the usual end-point titres or by fluorescent intensity measurements on antigens. the malarial antibody levels could also be measured by the fluorescent intensity measurements at a single serum dilution. thus the fluorescent intensity measurements could effectively replace the end point titre determination, with the advantages of standardization and s ... | 1978 | 364784 |
| an ultrastructural study of the sporogonic development of plasmodium falciparum in anopheles gambiae. | this paper describes the fine structure of the sporogonic development of plasmodium falciparum in its natural vector anopheles gambiae (species a) as seen by scanning and transmission electron microscopy. the parasite was derived from naturally infected volunteers and the vector maintained under natural conditions at the mrc laboratories, fajara, the gambia. sporogonic development of p. falciparum is similar to that described for other plasmodium spp. there are however greater similarities betwe ... | 1978 | 364785 |
| concentration from continuous culture of erythrocytes infected with trophozoites and schizonts of plasmodium falciparum. | gelatin, from readily available sources, at specified concentrations in rpmi 1640 medium enhances sedimentation rates of suspensions of plasmodium falciparum-infected erythrocytes from continuous cultures, resulting in an enrichment of the trophozoite- and schizont-infected cells to parasitemias of 75% or more with no deleterious effects to the parasites. | 1978 | 365006 |
| further epidemiological evaluation of a malaria model. | the malaria model previously fitted to 1 year of baseline data from the garki district in the sudan savanna of northern nigeria was tested against data collected in the same area over a period of 3 years, including 1(1/2) years during which the insides of houses in certain villages were sprayed with propoxur. it was also tested against data collected in kisumu, kenya, also over a period of 3 years, including 20 months during which the insides of houses in part of the area were sprayed with fenit ... | 1978 | 365384 |
| longitudinal serological study of malaria in infants in the west african savanna. comparisons in infants exposed to, or protected from, transmission from birth. | two infant populations, the one exposed to intense malaria transmission and the other protected, were followed and compared by six serological tests. the igg and igm levels increased with age and were systematically, though only slightly, lower in the protected children. the results of three plasmodium falciparum tests (precipitin, indirect fluorescent antibody (ifa) and indirect haemagglutination and one p. malariae test (ifa) were high at birth and decreased rapidly afterwards in both populati ... | 1978 | 365385 |
| changing patterns in the humoral immune response to malaria before, during, and after the application of control measures: a longitudinal study in the west african savanna. | a longitudinal seroimmunological investigation of malaria was performed as part of the who research project conducted in the northern part of nigeria from 1970 to 1975. the project included a preintervention phase, an intervention phase with application of malaria control measures (spraying of residual insecticide and mass drug administration), and a postintervention phase. serological observations were made on the total population of eight villages consisting of approximately 3000 persons. six ... | 1978 | 365386 |
| plasmodium falciparum: merozoite invasion in vitro in the presence of chloroquine. | 1978 | 365561 | |
| presumptive treatment of p. vivax and p. falciparum cases with 600 mg. chloroquine base in tamil nadu. | 1978 | 365722 | |
| a comparative study of malaria prophylaxis in peninsular malaysia using chloroquine and a combination of sulphadoxine and pyrimethamine. | 1978 | 366165 | |
| malaria prophylaxis for visitors to papua new guinea. | 1978 | 366358 | |
| chloroquine-resistant falciparum malaria. | 1978 | 366363 | |
| the treatment of malaria. | 1978 | 366774 | |
| hypocomplementaemia in children with plasmodium falciparum malaria. | 1978 | 366818 | |
| [autochthonous malaria and malarian liver. apropos of 1 case]. | report of the case of a patient, store-keeper at the roissy airport, suffering from an autochtonous primo-invasion falciparum malaria. the clinical symptoms were hectic fever and painful hepatomegalia, followed 14 days after by a typical tertian fever. all investigations being negative, a laparoscopy was carried out, which showed a black liver, and a biopsy demonstrated the malaria pigment in küpffer cells. malaria was confirmed by the study of a blood smear. this diagnostic hypothesis had not ... | 1978 | 385159 |
| serum protein fractions in acute falciparum malaria obtained by polyacrylamide gel electrophoresis. | 1978 | 350171 | |
| observations on malaria in an industrial area of chotonagpur. | 1978 | 383847 | |
| vaccination of experimental monkeys against plasmodium falciparum: a possible safe adjuvant. | owl monkeys (aotus trivirgatus griseimembra) were effectively immunized against a human malaria parasite, plasmodium falciparum. two injections of antigen, primarily mature segmenters with fully developed merozoites, mixed with adjuvant (6-o-stearoyl-n-acetylmuramyl-l-alanyl-d-isoglutamine and liposomes) were administered intramuscularly at a 4-week interval. approximately 2 weeks after the second vaccination, the monkeys were challenged with the homologous strain of p. falciparum. all immunized ... | 1978 | 99814 |
| the influence of acetylator phenotype on the response to sulfalene in individuals with chloroquine-resistant falciparum malaria. | the disposition of sulfalene was studied in eight individuals before and during an infection with a chloroquine-resistant strain of plasmodium falciparum. isoniazid acetylator phenotype was determined in each individual prior to the administration of sulfalene. following the administration of sulfalene before infection with malaria, a significant difference in half-life of non-acetylated sulfalene and percent acetylation of sulfalene in plasma was observed between rapid and slow acetylators. whe ... | 1978 | 347958 |
| [two new cases of autochtonous malaria in the parisian area showing two different modes of contamination]. | 1978 | 383308 | |
| [susceptibility of anopheles maculipennis sacharovi and anopheles maculipennis subalpinus mosquitoes to infection with the causative agents of tropical malaria brought in from africa]. | 1978 | 149904 | |
| diet and cerebral malaria: the effect of famine and refeeding. | in an outbreak of plasmodium falciparum malaria following refeeding after famine cerebral malaria was restricted to children eating grain. nomad children consuming a predominantly milk diet were free of this complication despite an equivalent incidence of uncomplicated malaria. freedom of nomads from cerebral complications may be due to inhibition by the milk diet of rapid division of the parasite combined with delayed recovery after famine of t cell function. | 1978 | 339705 |
| [malaria incurred in france]. | 1978 | 353710 | |
| [malaria: direct interhuman contamination]. | 1978 | 353711 | |
| [errors in diagnosis of imported malaria]. | 1978 | 354017 | |
| [imported malaria in the soviet and foreign citizens]. | 1978 | 354018 | |
| lymphocyte mitogenic factor in sera from patients with falciparum malaria. | to test for the presence of a lymphocyte mitogenic factor in malaria, sera were obtained from 10 patients with malaria (9 with falciparum and one with vivax), and 10 noninfected controls. the sera from the malarial patients caused an increased blastogenesis in mouse splenic lymphocyte cultures and inhibited hemagglutination between lipid-a-coated erythrocytes and lipid-a antibodies. none of the sera were positive using the limulus amebocyte lysate test. these results could be interpreted to demo ... | 1978 | 354145 |
| the biological suppression of malaria: an ecological and nutritional interrelationship of a host and two parasites. | the interrelationship of malaria and severe ascariasis was studied in anjouan children with a previously described syndrome of enlarged parotids, localized forehead edema, heavy infestation with ascaris lumbricoides, and unusual freedom from malaria. after treatment of 37 such children with the ascaricide piperazine, 35 had resolution of parotid enlargement and forehead edema, but 19 developed attacks of malaria. children treated with placebo had neither resolution of clinical findings nor attac ... | 1978 | 354372 |
| chloroquine resistance in zambia. | 1978 | 354744 | |
| [acute renal failure and attack of pernicious malaria (apropos of 3 further cases)]. | 1978 | 349298 | |
| falciparum malaria. | 1978 | 349318 | |
| cerebral malaria. a disseminated vasculomyelinopathy. | neuropathologic examination of 19 fatal cases of cerebral malaria and a review of the literature showed that the epidemiologic, clinical, and pathologic features of this entity suggest consideration of cerebral malaria as a form of disseminated vasculomyelinopathy, a hyperegic reaction of the cns to the antigenic challenge of plasmodium falciparum infection. experimental evidence also substantiates this view the initial event seems to be vasculopathy, with alteration of the endothelial permeabil ... | 1978 | 348169 |
| [malaria; a summary]. | 1978 | 348605 | |
| studies of immunoglobulin m and malarial antibodies in nigerians. | measurements of immunoglobulin m, in 111 healthy adult nigerians have been presented. igm values ranged between 10 and 518 mg per 100 ml with a mean of 213.2 mg per 100 ml. using the indirect immunofluorescent antibody test, 53.7 per cent of the 111 symptomless subjects in the study had demonstrable malarial antibodies of titres greater than 10,000. the implications of the observations in a holoendemic malarial zone are briefly discussed. | 1978 | 347102 |
| erythrocytic mechanism of sickle cell resistance to malaria. | the physiological basis for the resistance to falciparum malaria individuals with sickle cell trait has not been understood. recent advances in erythrocytic plasmodium falciparum culture have made possible a direct investigation of the development of the malaria parasite in cells with sickle cell homoglobin. in a high (18%) oxygen atmosphere, there is no apparent sickling of cells, and the growth and multiplication of p. falciparum is identical in normal (aa), hemoglobin s homozygous (ss), and h ... | 1978 | 347452 |
| [malaria prophylaxis]. | 1978 | 342981 | |
| [clinical problems in current malaria. considerations apropos of 2 cases]. | two cases of malaria imported from west africa by two sailors (falciparum and vivax respectively) are reported. it is pointed out that nowadays malaria is no longer indigenous to sicily but has to be imported; an increasing number of cases of malaria are being reported world-wide in relation to increased traffic volumes, particularly air traffic. this means growing importance of imported pathology for which a new training strategy is required (with regard to young physicians who at present are q ... | 1978 | 342993 |
| antimalarial activity of s-isobutyl adenosine against plasmodium falciparum in culture. | 1978 | 340273 | |
| plasmodium falciparum malaria: probable role of mosquitoes imported by aerial way. | 1978 | 24831 | |
| gametocyte and gamete development in plasmodium falciparum. | 1978 | 27809 | |
| drug sensitivity of plasmodium falciparum. an in-vitro microtechnique. | 1978 | 74500 | |
| low erythrocyte pyridoxal-kinase activity in blacks: its possible relation to falciparum malaria. | the red-cell glucose-6-phosphate dehydrogenase (g.-6-p.d.) activity and red-cell pyridoxal-kinase (p.l.k.) activity of 27 nigerian children with severe plasmodium falciparum parasitaemia were compared with those of 26 healthy nigerian children and 6 white adults. the mean p.l.k. activity of the malaria patients was similar to that of the whites but significantly higher than that of the nigerian controls. correction for reduced mean red-cell age in patients was made by comparing the p.l.k.: g.-6- ... | 1978 | 76019 |
| impairment of the immune response to vaccination after acute malaria. | children with acute malaria were vaccinated with salmonella typhi and meningococcal vaccines at varying times after the onset of their illness. the immune response to both vaccines was depressed when they were given on the day of presentation at hospital. immune responsiveness to s. typhi vaccine was rapidly regained after treatment, but a month after the attack the immune response to meningococcal vaccine was still impaired. | 1978 | 78096 |
| transient changes in serum lipoproteins during antimalarial therapy and malaria. | 1978 | 80548 | |
| malaria and immunology. | 1978 | 81994 | |
| cultured plasmodium falciparum used as antigen in a malaria indirect fluorescent antibody test. | human sera obtained from persons infected with plasmodium falciparum were tested by a standard indirect fluorescent antibody (ifa) technique using antigen obtained from long term in vitro cultures of two strains of p. falciparum, and antibody in high titer was reproducibly detected. sera from uninfected persons had undetectable or very low titers of antibody. the use of cultured parasites offers a convenient, stable source of antigens from different p. falciparum strains without requiring their ... | 1978 | 82407 |
| studies on the burma (thau.) strain of plasmodium falciparum in aotus trivirgatus monkeys. | the burma (thau.) strain of plasmodium falciparum was established in 3 aotus trivirgatus monkeys by the inoculation of parasitized blood from man. subsequently, passage from monkey to monkey was obtained through subinoculation of blood parasites to 15 aotus monkeys. anopheles freeborni mosquitoes were fed on these infections on 207 occasions; in 105 of these trials, mosquitoes became infected. a total of 335 (9.9%) of the 3,378 individual mosquitoes dissected were infected. passage of the infect ... | 1978 | 96244 |
| stage-specific antigens on the surface membrane of sporozoites of malaria parasites. | 1978 | 96355 | |
| quinine-like drug attacks resistant malaria strains. | 1978 | 97402 | |
| antimalarial activities of various 4-quinolonemethanols with special attention to wr-142,490 (mefloquine). | pilot appraisals of the activities of a selected group of 4-quinolinemethanols against acute plasmodium falciparum infections in owl monkeys indicated that compounds of this class are equally active against infections with chloroquine-resistant and chloroquine-susceptible strains and that this efficacy is not compromised by concomitant resistance to pyrimethamine, and in addition, identified three derivatives with outstanding activity (wr-226,253; wr-142,490; and wr-184,806). wr-142,490, the sec ... | 1978 | 98104 |
| immunopathology of malaria. | 1978 | 98476 | |
| summing up of the symposium: immunology and immunopathology of malaria. | 1978 | 98477 | |
| malaria immunity induced by infection with cultured parasites of plasmodium falciparum. | 1978 | 98625 | |
| [immuno-electro-diffusion on cellulose acetate membrane for serological testing in human malaria (author's transl)]. | an immuno-electro-diffusion assay for human malaria, using cellulose acetate gel, is described. more than 3500 sera have been tested by this method, which proved very useful for epidemiology since 400 sera a day can be tested by one person, with simple equipment. its sensitivity compared well to the ifa test, although the antibodies revealed are quite different. a constnat precipitin line appeared, against 56 degrees c labile antigens, in sera of subjects infected by p. falciparum, and up to 8 o ... | 1978 | 98748 |
| plasmodium falciparum and plasmodium vivax infections in the owl monkey (aotus trivirgatus). i. the courses of untreated infections. | this study, the first of three designed to determine the feasibility of using owl monkeys infected with human plasmodia in the search for new, more broadly active antimalarial drugs, dealt with the characteristics of untreated infections with eight strains of plasmodium falciparum and two strains of p. vivax. such infections, induced by standardized inocula of these strains in 1,733 monkeys, all aotus trivirgatus griseimembra, were followed from day of inoculation to death of self-cure. the viru ... | 1978 | 99055 |
| plasmodium falciparum and plasmodium vivax infections in the owl monkey (aotus trivirgatus). ii. responses to chloroquine, quinine, and pyrimethamine. | the studies described in this report were designed to determine the responses of established infections with eight strains of plasmodium falciparum and two strains of p. vivax in owl monkeys to treatment with chloroquine, quinine, and pyrimethamine. responses with these different strains ranged from cure via application of well-tolerated doses of two of the above drugs and refractoriness to treatment with maximally tolerated doses of the third, to complete resistance to maximally tolerated doses ... | 1978 | 99056 |
| plasmodium falciparum and plasmodium vivax infections in the owl monkey (aotus trivirgatus). iii. methods employed in the search for new blood schizonticidal drugs. | this report describes, illustrates, and validates the major features of a procedure designed to provide primary assessments of the activities of potential antimalarial drugs against infections with chloroquine-resistant or pyrimethamine-resistant strains of plasmodium falciparum in owl monkeys of colombian origin. studies with 14 specially selected compounds have shown that the test method has the capacity to identify and quantify diverse levels of therapeutic efficacy among agents that differ w ... | 1978 | 99057 |
| effect of falciparum malaria infection on the in vitro mitogen responses of spleen and peripheral blood lymphocytes from owl monkeys. | the response of spleen and peripheral blood lymphocytes (pbl) to mitogen stimulation with phytohemagglutinin (pha), concanavalin a (cona), and pokeweed mitogen (pwm) was determined for owl monkeys (aotus trivirgatus) experimentally infected with the vietnam-oak knoll (fvo) and the uganda-palo alto (fup) strains of plasmodium falciparum. pbl from panamanian aotus monkeys with less than 25% fvo infection responded normally to mitogen stimulation; however, increased parasitemia of 25--50% resulted ... | 1978 | 99058 |
| antimalarial activities of various 9-phenanthrenemethanols with special attention to wr-122,455 and wr-171,669. | pilot appraisals of the activities of 16 specially selected 9-phenanthrenemethanols against acute infections with plasmodium falciparum in owl monkeys showed that all were more active than the reference compound, wr-33,063. wr-122,455, the most active derivative, and wr-171,669, ranked sixth, were selected for study in human volunteers. to assist this undertaking, appraisals of both compounds in owl monkeys infected with various strains of p. falciparum were expanded. these assessments showed: ( ... | 1978 | 101127 |
| antimalarial activities of various 4-pyridinemethanols with special attention to wr-172,435 and wr-180,409. | pilot appraisals of the activities of 10 specially selected 2,6-substituted-4-pyridinemethanols against acute plasmodium falciparum infections in owl monkeys identified three derivatives that were two to three times as active as chloroquine against infections with a 4-aminoquinoline-susceptible strain and, at the same doses, were equally effective against infections with a strain fully resistant to treatment with maximally tolerated doses of chloroquine, quinine, and pyrimethamine. two of these ... | 1978 | 101132 |
| suppression of lymphocyte transformation by plasma from owl monkeys acutely infected with plasmodium falciparum. | plasma collected from owl monkeys during the acute phase of plasmodium falciparum infection was shown to adversely affect several in vitro responses which are considered to be correlates of cell-mediated immune functions of normal monkeys. in the presence of acute-phase plasma, response of normal monkey peripheral blood lymphocytes to stimulation with phytohemagglutinin, concanavalin a, and pokeweed mitogen was severely reduced, as was the ability of peripheral blood lymphocytes to respond to al ... | 1978 | 101455 |
| [an epidemiological consideration of the status of infection in 29 patients with malaria (author's transl)]. | 1978 | 101609 | |
| folate antagonists. 13. 2,4-diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. | an array of nonclassical thioquinazoline analogues (viii) of methotrexate was prepared by cyclization of the requisite 2-amino-5-(arylthio)benzonitrile with chloroformamidine hydrochloride (28--79%). the aminonitrile precursors were obtained by sncl2-hcl reduction (28--99%) of the corresponding 2-nitro-5-(arylthio)benzonitriles, which were synthesized by the condensation of the appropriate 5-chloro-2-nitrobenzonitriles with various arylthiols (36--83%). many of the thioquinazolines (viii) showed ... | 1978 | 102792 |
| immunization against malaria with antigen from plasmodium falciparum cultivated in vitro. | aotus monkeys, which are generally killed when infected with the human malaria parasite plasmodium falciparum, have been identified and grouped by karyotype. these animals were immunized with parasite material obtained from p. falciparum cultivated in vitro which had been maintained in culture for over a year. when sufficient amounts of this antigenic material were used with a synthetic muramyl dipeptide (mdp), protective immunity was induced without presenting the antigen in complete freund's a ... | 1978 | 103100 |
| partial protection of plasmodium falciparum-vaccinated aotus trivirgatus against a challenge of a heterologous strain. | two aotus trivirgatus griseimenbra monkeys which had been immunized with the merozoite-enriched fup strain of plasmodium falciparum were protected against a primary challenge with the homologous strain. the results described here show that these two monkeys were protected against a subsequent challenge with a heterologous strain (fvo) of p. falciparum. the unimmunized control monkey died of fvo infection by day 18. | 1978 | 103450 |
| antimalarial activities of wr-194,965, an alpha-amino-o-cresol derivative. | pilot appraisals of the activities of wr-194,965 and wr-204,165, two closely related o-cresol derivatives (both mannich bases), in owl monkeys infected with the multidrug-resistant vietnam smith strain of plasmodium falciparum showed that these compounds had similar levels of efficacy. total course doses effecting 90% cures (cd(90)s) were 27 and 37 mg/kg of body weight for the respective compounds, values almost identical to the cd(90) of mefloquine (a highly promising 4-quinolinemethanol) again ... | 1978 | 103492 |
| antimalarial activities of the 4-quinolinemethanols wr-184,806 and wr-226,253. | wr-184,806 and wr-226,253, two 4-quinolinemethanols structurally similar to wr-142,490 (mefloquine), have been studied in depth in owl monkeys infected with various drug-resistant and drug-susceptible strains of plasmodium falciparum and p. vivax in an effort to provide support and guidance for projected evaluations in human volunteers. the results of these studies, confirmatory of preliminary appraisals, showed that wr-184,806 was approximately one-third as active as wr-142,490 against infectio ... | 1978 | 103493 |
| fine structure of human malaria in vitro. | the erythrocytic cycle of the human malaria parasite, plasmodium, falciparum, was examined by electron microscopy. three strains of parasites maintained in continuous culture in human erythrocytes were compared with in vivo infections in aotus monkeys. the ultrastructure of p. falciparum is not altered by continuous cultivation in vitro. mitochondria contain dna-like filaments and some cristae at all stages of the erythrocytic life cycle. the golgi apparatus is prominent at the schizont stage an ... | 1978 | 105129 |
| application of radioisotopes in the study of malaria in thailand. | 1979 | 109557 | |
| susceptibility of owl monkeys to plasmodium falciparum infection in relation to location of origin, phenotype, and karyotype. | the relationship among geographic origin, phenotype, karyotype, and susceptibility of owl monkeys to 2 strains of plasmodium falciparum was investigated. owl monkeys from columbia and panama were both susceptible to fatal infections with the asian fvo (vietnam-oak knoll) strain of p. falciparum. however, when inoculated with the african fup (uganda-palo alto) strain, most colombian owl monkeys developed fatal or potentially fatal (bled out with parasitemias of over 25%) infections, but panamania ... | 1979 | 109608 |
| inhibition of the in vitro growth of plasmodium falciparum. i. the effects of immune serum and purified immunoglobulin from owl monkeys. | sera from aotus sp. monkeys (karyotypes ii, iii, and iv) which were immune to plasmodium falciparum have been used to inhibit the in vitro growth of this human malaria parasite. culture conditions used for the assays allowed 50- to 100-fold increases in the number of a+ erythrocytes infected in a 96-hr period in control cultures. although normal monkey serum did not support growth as well as normal human serum, mixtures of normal monkey and human serum were found that did. compared to such contr ... | 1979 | 113460 |
| studies on the 2,4-diamino-6-substituted quinazolines. ii. activities of selected derivatives against infections with various drug-susceptible and drug-resistant strains of plasmodium falciparum and plasmodium vivax in owl monkeys. | four 6-thio-, one 6-sulfinyl-, and two 6-sulfonyl-substituted 2,4-diaminoquinazolines were evaluated for capacities to cure established infections with the chloroquine-resistant vietnam oak knoll and pyrimethamine-resistant malayan camp-ch/q strains of plasmodium falciparum in owl monkeys. as compared with the doses of standard drugs required for cure of infections with drug-susceptible strains or doses of the newly developed aminoalcohols required for cure of either drug-susceptible or drug-res ... | 1979 | 114065 |
| studies on the 2,4-diamino-6-substituted quinazolines. iii. the capacity of sulfadiazine to enhance the activities of wr-158,122 and wr-159,412 against infections with various drug-susceptible and drug-resistant strains of plasmodium falciparum and plasmodium vivax in owl monkeys. | previous studies showed: 1) that the activities of the 2,4-diamino-6-substituted quinazolines. wr-158,122 and wr-159,412, against plasmodium falciparum and plasmodium vivax infections in owl monkeys, were seriously impaired when infecting strains were pyrimethamine-resistant; and 2) that primary treatment failure with either agent led frequently to emergence of parasites resistant to these derivatives. taking advantage of the potencies of wr-158,122 and wr-159,412 as dihydrofolic acid reductase ... | 1979 | 114066 |
| the enzyme-linked immunosorbent assay (elisa) for malaria. i. the use of in vitro-cultured plasmodium falciparum as antigen. | using the panama ii strain of plasmodium falciparum obtained from continuous in vitro culture as antigen, the micro enzyme-linked immunosorbent assay (elisa) was used to test serum samples from 50 persons from the southeastern united states and serum specimens collected weekly from four non-immune and nine semi-immune patients infected with p. falciparum. none of the 50 sera from the united states had elisa antibody titers greater than 1:80. the nine semi-immune patients had rapid elisa antibody ... | 1979 | 116555 |
| effect of sequential infection with plasmodium vivax and p. falciparum in the aotus trivirgatus monkey. | aotus trivirgatus monkeys with prior experience with plasmodium vivax were inoculated with p. falciparum via the bites of infected mosquitoes. the animals with prior malaria had higher parasitemias and significantly higher levels of mosquito infectivity than monkeys with no prior p. vivax experience. monkeys with a history of p. falciparum that were inoculated with p. vivax had essentially the same parasitemias as those with no prior malaria. however, levels of mosquito infectivity were markedly ... | 1979 | 117086 |
| studies on the west african i strain of plasmodium falciparum in aotus trivirgatus monkeys. | the west african i strain of plasmodium falciparum was isolated from a commercial airline pilot who had an overnight stay in nigeria. once established in the aotus trivirgatus griseimembra monkey, the parasite produced high parasitemias and readily infected mosquitoes. anopheles freeborni and an. maculatus mosquitoes transmitted the infection to additional animals. infected salivary glands were also seen in an. culcifacies. comparative infectivity studies indicated the most susceptible mosquito ... | 1979 | 117091 |
| bleeding diathesis in malaria. | 1979 | 117556 | |
| antimalarial properties of floxacrine, a dihydroacridinedione derivative. | evaluations of the activities of floxacrine [7-chloro-10-hydroxy-3-(4-trifluoromethylphenyl)-3,4-dihydroacridine-1,9(2h, 10h)-dione] in owl monkeys infected with trophozoites of a chloroquine-quinine-resistant strain of plasmodium falciparum, a strain of this plasmodium resistant to both of these quinolines and pyrimethamine, or a strain of p. vivax resistant only to pyrimethamine showed that: (i) this compound regularly effected temporary clearance of parasitemia at daily doses of 1.25 to 2.5 m ... | 1979 | 117747 |
| renal disease in acute plasmodium falciparum infection in man. | 1979 | 119089 | |
| [advantages of the errecart's technique for the identification of plasmodium (author's transl)]. | errecart (1945) proposed a modified technique for making thick films for the diagnosis of chaga's disease. we applied his technique to the study of malaria in mammals; the morphology of the blood parasites is very well preserved and allows the identification of species which are frequently not identifiable in ordinary thick films. | 1979 | 120125 |
| [current information on treatment and prophylaxis of malaria (author's transl)]. | malaria is not a disease of the past. as long as worldwide eradication has not been achieved there is a close connection between countries which export it and those which import it. if the european doctor is presently confronted with a feverish disease which may have been brought in from a tropical area, he should immediately think of malaria and take the necessary measures for treatment. if patients or travelers come into the office and enquire about drugs and preventive measures against malari ... | 1979 | 120502 |
| factors affecting the in vitro culture of plasmodium falciparum and plasmodium knowlesi. | plasmodium falciparum and plasmodium knowlesi have been established in continuous culture using the basic method of trager & jensen. various parameters of the culture system have been examined, namely, the gas requirements, serum and red cell requirements, frequency of medium replacement, and a comparison of static and agitated cultures made. the most important factors affecting growth in vitro seem to be the oxygen tension, red cell concentration, the frequency with which old medium is replaced ... | 1979 | 120767 |