Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| toxin production by strain c7 (beta), its mutants and their l-phase variants of corynebacterium diphtheriae. | 1977 | 406436 | |
| heat-inducible mutants of corynebacteriophage. | heat-inducible mutants of temperate cornebacteriophage beta and gamma, called temperature-sensitive repression (tsr) mutants, were isolated and characterized. lysogens carrying these mutants were induced at 38 degrees c, produced a normal or slightly increased yield of phage, and underwent extensive lysis at this temperature. in some cases mutation to heat inducibility had altered the uv inducibility of the phage, the changes ranging from loss to enhancement of this trait. complementation tests ... | 1977 | 408516 |
| bacteriophage production by doubly lysogenic corynebacterium diphtheriae. | parental and recombinant phage production by tandem, double lysogens of corynebacterium diphtheriae was studied in strains in which the coupling of prophage markers and the order of prophage was established. the results from studies of mass lysates and single bursts showed that the recombinant class of phage, designated r1, was predominant in uv-induced lysates followed by the parental, p1 class and to a lesser extent the p2 and r2 classes. single bursts of uv-treated cells contained phage from ... | 1977 | 408517 |
| carriage of non-toxigenic corynebacterium diphtheriae by australian aboriginals. | a survey of 200 aboriginals in western australia revealed five carriers of non-toxogenic corynebacterium diphtheriae; four of these were variety mitis and one was variety gravis. | 1977 | 408595 |
| biochemical characters to differentiate strains of corynebacterium diphtheriae, c. xerosis and c. hofmannii. | 1977 | 409666 | |
| isolation from corynebacterium diphtheriae c7(beta) of bacterial mutants that produce toxin in medium with excess iron. | five mutants that produce toxin in medium with excess iron were isolated from strain c7(beta). the iron content of bacteria grown on this medium was considerably higher than that of c7(beta) cells grown in medium containing the minimum amount of iron needed to inhibit toxin production. when the nonlysogenic, nontoxinogenic strain c7(-) was lysogenized with phages from each of the mutants, toxin production by all of the resulting lysogens, like that by parent strain c7(beta), ceased upon iron add ... | 1977 | 409685 |
| bacteriophage typing of corynebacterium diphtheriae. | bacteriophage types of over 3,000 strains of corynebacterium diphtheriae isolated in canada have been determined. the typing scheme used involved the use of nine phages. results indicated that phage types correlate with biotypes to a large degree. corynecin types were also determined for a limited number of cultures, and results indicated that the indicator strains presently available are unsuitable for the typing of c. diphtheriae strains isolated in north america. the distribution of phage typ ... | 1977 | 410896 |
| [extracellular material of some representatives of the genus corynebacterium (the electron microscopic aspect)]. | at the active developmental phases (up to 2 days) cells of toxigenic and nontoxigenic corynebacteria form extracellular vesicle-like material of two types which can be revealed both on whole cells set off by metal and stained negatively, and in ultrathin sections. extracellular material of the first type is a derivative of an extensive membranous coat of corynebacteria and is formed as a result of its fragmentation. vesicles of this type are devoid of electron microscope-dense content, have no t ... | 1977 | 411293 |
| [preliminary subdivision of corynebacteria related to c. diphtheriae var. gravis that ferment starch]. | 1977 | 411294 | |
| inhibition of diptheroid esterase by micrococcus luteus. | micrococcus luteus produced a diffusible, esterase inhibitory factor (eif) which inhibited the activity of cutaneous diphtheroid esterases on tween 80-cacl2 agar media. esterases of staphylococcus, micrococcus, bacillus, and serratia were not susceptible. eif did not appear to combine with the substrate or to prevent enzyme synthesis; it was unable to reverse the precipitation of calcium oleate. the composition of the medium, especially peptones, influenced the production of eif. eif was synthes ... | 1977 | 411559 |
| studies on the fine structure of corynebacterium diphtheriae-granules. | the seemingly homogeneous metachromatic and electron-scattering granules of corynebacterium diphtheriae have two structural components as revealed under conditions of low beam load and by use of ribonuclease. they contain high percentages of p and ca. findings point to participation of ribosomes and intracytoplasmic membranes in the formation of the granules. | 1977 | 412349 |
| [the species c. diphtheriae]. | corynebacteria (c. diphtheriae var. gravis, mitis, minimus, intermedius, c. belfanti, c. ovis, c. ulceraus) producing diphtheria toxin are found as variants sharply differing from one another morphologically (from long branching rods to coccobacilli), culturally, biochemically and by other signs. the toxin synthesis in them was determined by genetically heterogeneous prophages tox+; tox+ virus exchange is possible between the corynebacteria. since production of specific toxin, the cardinal sign ... | 1977 | 413292 |
| [diphtheria epidemic occurring on the north shore of the st. lawrence river in the fall of 1974]. | an outbreak of diphtheria occurred on the north shore of the st. lawrence river at the beginning of september 1974. it started with the death of an 18-year-old forest worker sept. 5, spread over a vast area of the north shore and lasted until the end of october that year. eleven strains of toxigenic corynebacterium diphtheriae intermedium, type k were isolated. eleven of the 12 patients had characteristic diphtheritic pharyngitis with pseudomembranes. preventive measures, set forth immediately a ... | 1977 | 861886 |
| [determination of the intensity of antimicrobial immunity in diphtheria during an acute experiment]. | the authors elaborated a method of determination of the antimicrobial immunity intensity in diphtheria in an acute experiment: guinea pigs were infected with a virulent culture of corynebacterium diphtheriae grown on agar with iron in a concentration depressing the toxinogenesis. a temporary absence of the toxin formation permitted to evaluate the antibacterial immunity except the antitoxic one. guinea pigs preimmunized with somatic corynebacterium diphtheriae antigen or an immune antimicrobial ... | 1977 | 899456 |
| diphtheria corneal ulcers. | an adult with cutaneous diphtheria was admitted with bilateral purulent conjunctivitis and a perforated eye with most of the cornea absent due to corynebacterium diphtheriae. at the time of admission of grayish patch of corneal epithelium was noted in the other eye, and in the next 24 hours there developed a large corneal perforation with dissolution of much of the cornea. involvement of the external eye in diphtheria is rare but it is usually associated with cutaneous forms of the disease. cuta ... | 1978 | 414704 |
| determination of corynebacterium diphtheriae toxigenicity by a colorimetric tissue culture assay. | chinese hamster ovary (cho) cell cultures in microtiter wells are sensitive to growth inhibition and killing by picogram quantities of diphtheria toxin. in the absence of biologically active toxin, the cho cell culture produces sufficient acidic metabolites to change the phenol red ph indicator from pink to yellow within 56 h. in the presence of 10 pg of toxin per well, growth inhibition can be observed microscopically within 24 h. diphtheria toxin can be qualitatively assayed from culture super ... | 1978 | 415068 |
| relationship between beta converting and gamma non-converting corynebacteriophage dna. | 1978 | 415247 | |
| mass spectrometry of acylated sugars as trimethylsilyl ether derivatives. a way for location of long chain fatty acyl groups. | the mass spectra of the trimethylsilyl ethers of the four positional isomers of methyl-o-palmitoyl-alpha-d-glucopyranoside have been studied, and the structures of the principal ions assigned by the use of exact mass measurements and deuterium labelling on the aliphatic chain, the trimethylsilyl group and the glucosidic methyl group. the origin of some fragments has been elucidated by analysis of reactions of metastable ions. the mass spectra of the different isomers exhibit major differences, w ... | 1978 | 415769 |
| nonspecific immunostimulant activities of synthetic trehalose-6,6'-diesters (lower homologs of cord factor). | mycobacterial cord factors (6,6'-diesters of trehalose with mycolic acids ranging from c80 to c90) have been shown to protect mice effectively against infection with klebsiella pneumoniae or with listeria monocytogenes. our present findings indicate that the low-molecular-weight cord factor of corynebacterium diphtheriae (with corynomycolic acids ranging from c28 pto c36) is equally active. moreover, its synthetic analog (with synthetic c32 mycolic acid) has the same activity. two lower syntheti ... | 1978 | 352926 |
| [comparative study of the reactogenicity of dtp vaccine, dt and modified dt anatoxins in revaccinating 6-year-old children]. | 1978 | 208331 | |
| isolation and characterization of extragenic suppressor strains of corynebacterium diphtheriae. | the isolation and characterization of two different nonsense suppressor strains of corynebacterium diphtheriae c7 sup+(-)tox- are described. appropriate lysogens of these strains with corynephage beta, carrying known class ii tox premature polypeptide chain termination mutations [c7sup-1(betatox-30) and c7sup-2(betatox-45)], each produce a 62,000-dalton polypeptide with nicotinamide adenine dinucleotide: elongation factor-2 adenosine diphosphate ribosyltransferase activity in addition to a chain ... | 1978 | 214419 |
| epidemiological features of skin diphtheria infection in rangoon, burma. | a survey for skin diphtheria was carried out on 493 patients with skin lesions who were attending veneral diseases & dermatology clinic in rangoon in 1971. 63.8% of the patients had c. diphtheriae in their skin lesions. all ages and both sexes were equally affected. skin lesions yielding c. diphtheriae on culture were indistinguishable from those associated with other bacteria including ecthyma, pyoderma and secondarily infected with parasitic infections. out of 108 strains tested 18.5% were fou ... | 1978 | 151920 |
| studies on the pw 8 phage of the park williams no. 8 strain of c. diphtheriae and on species within corynebacterium genus capable of producing diphtherial toxin. | 1978 | 120166 | |
| an unusual case of cutaneous diphtheria. | 1978 | 79663 | |
| [bacteriocinogenic activity of corynebacterium diphtheriae]. | 1978 | 81920 | |
| polypeptide antibiotic 26a from bacillus subtilis. iv. evaluation of biological in vivo activity. | the studies performed with the antibiotic 26a, which has a close resemblance to bacitracin family polypeptide antibiotics, revealed a prominent therapeutic and protective actions. the antibiotic is characterized by a moderately low toxicity, lack of cytotoxic and cytostatic effects on several tissue cultures, and therapeutic effectiveness in lethal streptococcal infections in mice, and corynebacterial infections in guinea pigs. | 1978 | 86285 |
| value of acid metabolic products in identification of certain corynebacteria. | acid metabolic products of 23 strains of human and animal pathogenic corynebacteria, representing eight different species, were determined by gas chromatography. the results showed that the species examined were metabolically heterogeneous and could be presumptively identified based on the acid products produced. corynebacterium equi did not produce any acids; c. renale produced lactate; and c. pyogenes produced major amounts of lactate, variable amounts of acetate, and minor amounts of succinat ... | 1978 | 96126 |
| rapid determination of corynebacterium diphtheriae toxigenicity by counterimmunoelectrophoresis. | a method for detecting toxin production in corynebacterium diphtheriae cultures by counterimmunoelectrophoresis is described. precipitin lines were observed in toxigenic strains in 30 min. | 1978 | 96129 |
| isolation of the l-phase variant from toxigenic corynebacterium diphtheriae c7(beta). | the l-phase variant was isolated from lysogenic strain c7(beta) of corynebacterium diphtheriae by the penicillin disk tecnnique on an agar medium containing 3.7% brain heart infusion, 3% nacl, 1.25% grycine, 1% noble agar, and 10% horse serum. the l-phase formed a "fried egg" colony; it was resistant to antibiotics that inhibit biosynthesis of bacterial cell walls but was susceptible to antibiotics that act on the protein-synthesizing system. after several transfers of the l-phase initially isol ... | 1978 | 97222 |
| role of exotoxins in bacterial pathogenicity. | 1978 | 97256 | |
| [prospects for the use of blood substitutes made in the ussr with the expired date of validity]. | as revealed, blood substitutes--aminopeptide, caseine hydrolysate, and hydrolysine with the expired date of validity could be used as the basis of nutrient media for the cultivation of bacteria. bacterial growth proved to be the optimum in addition to the blood substitutes of a 0.25--0.5% of yeast extract. | 1978 | 97885 |
| evidence that the regulation of diphtheria toxin production is directed at the level of transcription. | it has been known for several decades that iron inhibits the production of diphtheria toxin by corynebacterium diphtheriae by preventing expression at maximal levels. we examined the inhibition kinetics of toxin production after the addition of either iron or rifampin to iron-limited cultures of c7 (betatox+). iron-mediated inhibition of toxin production was found to be linear within the range of 16 nm to 16 micron. the inhibition kinetics following the addition of iron or rifampin was almost id ... | 1978 | 98519 |
| vaccination and hodgkin's disease. | 1978 | 99187 | |
| [serologic relationship between toxigenic and nontoxigenic c. diphtheriae with reference to the cultural variant gravis]. | 1978 | 99927 | |
| [epiedmiologic significance of the distribution of corynephages in different collectives]. | corynephage distribution was studied in the nasopharyngeal washings of 252 persons infected with c. diphtheriae of gravis type, toxigenic (21 patients and 147 carriers) and non-toxigenic ones (84 carriers), and in 468 uninfected persons in collective bodies under different epidemic conditions. corynephages were isolated from the nasopharyngeal washings only in persons infected with toxigenic c. diphtheriae--in 4 (of 21) patients, and in 21% (of 147) carriers. phages tox+ (4--6.2%) were revealed ... | 1978 | 99930 |
| control of corynebacteriophage reproduction by heteroimmune repression. | corynebacteriophages beta and gamma are closely related but heteroimmune; hence, gamma reproduces in c7(beta). a series of gamma mutants, designated gamma-bin (beta-inhibited), has been isolated. they reproduce in only 2 to 14% of infected c7(beta) cells, and, as a result, plaque with an efficiency of 10(-4) to 10(-5) on this strain. the proportion of c7(beta) cells in which gamma-bin phage can replicate is increased to 30 to 80% when immunity is lifted by uv induction of c7(beta) or by heat ind ... | 1978 | 100610 |
| [comparative study of the bactericidal action of the body of ornithodoros papillipes ticks]. | experiments in vivo have shown that the ticks of ornithodoros papillipes inhibit both gram-positive and gram-negative bacteria. on gram-positive microorganisms most sensitive to bactericidal effect of ticks have turned to be micrococci, staphylococci, streptococci and bacteria of diphtheria, of gram-negative ones--bacillus coli. of gram-positive microorganisms less sensitive were listeria, of gram-negative ones--salmonellae, agents of tularemia and pseudotuberculosis. at the infection with bacte ... | 1978 | 100756 |
| isolation, structural studies and chemical synthesis of a 'palmitone lipid' from corynebacterium diphtheriae. | the isolation of a 'palmitone lipid' from corynebacterium diphtheriae is described. the use of a temporary hydrophobic protecting group allows the obtaining of the lipid in free and pure form. structural studies by chemical degradation and mass spectrometry allow one to propose structure ic for this compound, namely 6-(2-tetradecyl 3-keto octadecanoyl)-alpha-d-trehalose. this structure was confirmed by chemical synthesis. | 1978 | 102431 |
| quantitative studies on competitive activities of skin bacteria growing on solid media. | earlier quantitative investigations of antagonism between skin bacteria were based on the use of liquid cultures, but a more realistic model has now been devised, based on the use of the surfaces of solid media. pure or mixed inocula were spread evenly over suitable agar media in petri dishes marked out with a standard grid. growth curves were constructed from viable counts of the surface bacteria after they had been removed from excised squares of the agar media and dispersed. the method was hi ... | 1978 | 102799 |
| [participation of bacterial neuraminidases in the development of disease]. | 1978 | 103344 | |
| three variants of corynebacterium diphtheriae subsp. mitis (belfanti) isolated from a throat specimen. | three variants of a corynebacterium diphtheriae subsp. mitis strain belfanti, two toxigenic (phage types 7 and 11) and one nontoxigenic (phage type 7), were simultaneously isolated from the throat of an adult. | 1978 | 106070 |
| [heteromorphism of corynebacteria. i. macrocells]. | a possibility of formation of macrocells (mac) of diphtheria bacilli was expressed to a different degree; the extreme expression are giant and supergiant forms. giant forms with section dimension of 3--5micron retained their capacity to disorderly septation with the resultant formation of microcells (mic). apparently some of the septa were not realized. supergiant forms were revealed as a layer and its transverse section. the length of the latter reached 30micron with the transverse section of 2 ... | 1978 | 106605 |
| structural determination of 'cord factor' from a corynebacterium diphtheriae strain by a combination of mass spectral ionization methods: field desorption cesium cationization and electron impact mass spectrometry studies. | the composition and structure of a preparation of 'cord factor' (di-beta-hydroxy acyl trehaloses) from corynebacterium diphtheriae have been determined by a combination mass spectral ionization methods. the methods were tested by means of synthetic 6,6'-dicorynomycolate of alpha-d-trehalose prior to their use on natural products. the determination of the molecular weight of the components and the estimation of their relative abundance in the natural mixture were made by field desorption mass spe ... | 1978 | 106902 |
| a modified gel-diffusion technique for testing toxigenicity of corynebacterium diphtheriae. | 1978 | 108219 | |
| [identification of corynebacterium diphtheriae by way of immunofluorescence (author's transl)]. | the immunofluorescence technique (if) will be demonstrated as a time-saving method for identifying corynebacterium diphtheriae. in three test-series the if-test was performed on 74 strains of c. diphtheriae which had been isolated in a small case of epidemic in gelsenkirchen, on 4 strains of diphtheroids and on some strains to be found in the nasopharynx. all of these strains had been taken from blood agar, 69 toxinogenic strains of c. diphtheriae showed a clear, plainly reproducible fluorescenc ... | 1978 | 418603 |
| modified culture technique for corynebacterium diphtheriae isolation from desiccated swabs. | corynebacterium diphtheriae was isolated from pyoderma and ulcerative skin lesions with a modified delayed culture procedure as late as 9 weeks after field collection of silica gel-desiccated swabs. biotypes gravis and mitis were identified. most isolates were nontoxigenic. todd-hewitt broth enrichment enhanced recovery of c. diphtheriae by 70%. | 1978 | 416036 |
| studies on the inhibitory effects of zinc heptanoate on microorganisms. | inhibitory effect of zinc heptanoate was observed on different cultures of bacteria and fungi. growth of all the bacteria was inhibited by the compound. greatest inhibition was seen in the case of staphylococcus albus, streptococcus pyogenes, shigella dysenteriae, shigella sonnei, shigella flexneri, salmonella typhi, s. paratyphi a, s. paratyphi b, vibrio cholerae, corynebacterium diphtheriae, and e. coli whereas least inhibition was found in the case of staphylococcus aureus. in triethanolamine ... | 1979 | 553835 |
| epidemiologic studies among amerindian populations of amazônia. i. pyoderma: prevalence and associated pathogens. | pyoderma was studied among a representative sample of the residents of four remote amerindian villages, amazonas state, brazil, during july-august 1976. the overall prevalence among the 775 inhabitants examined was 11%, with little intervillage variation. when the attack rates for the entire sample population were calculated by 5-year age intervals, the 0- to 4-year-olds had the highest rate, 31%. the highest prevalence, 38%, was found among 3-year-olds. attack rates were not apparently related ... | 1979 | 110164 |
| [antibacterial immunity in diphtheria. experimental research]. | a number of 700 guinea pigs were immunized by parenteral route with non-toxigenic corynebacterium diphtheriae strains, then inoculated with various doses of homologous and heterologous toxigenic c. diphitheriae strains. the results showed that non-toxigenic c. diphtheriae strains confer a certain degree of protection when the challenge is done with homologous toxigenous strains, especially when not more than 500 million germs/ml are used for the challenge dose. this suggests that the carriage of ... | 1979 | 111333 |
| [heteromorphism of the corynebacteria. iii. d- (dark) and c- (clear) cell types and multiseptate specimens]. | a population of corynebacterium diphtheriae may consist of cells with accented (osmiophilic) cytoplasm (cells of the "dark" type, or d type) and cells with cytoplasm having no pronounced osmiophilic properties (cells of the "clear" type, or c type). the divergence of the population into cells of the d and c types occurs at the stage of cell division, the original mother cell being able to divide into 2 or more individual cells belonging to different types (elongated multiseptate cells). at the s ... | 1979 | 111440 |
| occurrence of 3-oxo-acyl groups in the 6,6'-diesters of alpha-d-trehalose. new glycolipids related to cord factor from corynebacterium diphtheriae. | 1979 | 111936 | |
| [a tropical ulcus cruris caused by corynebacterium diphtheriae?]. | 1979 | 112483 | |
| [interrelationship of toxin formation with proteolytic enzyme synthesis in the process of cultivating diptheria microorganisms]. | for the first time the synthesis of proteolytic enzymes by corynebacterium diphtheriae has been shown to precede the process of toxin formation. the process of controlling the proteolytic activity of enzymes seems to be a suitable basis for the evaluation of toxin formation in mathematically planned experiments with strictly controlled tasks. | 1979 | 112807 |
| [appearance in domestic animals of corynebacterium diphtheriae and other corynebacterium strains pathogenic for man]. | 1979 | 113847 | |
| activity of penicillin, erythromycin, and cephalosporins against isolates of corynebacterium diphtheriae from cutaneous lesions. | 1979 | 114513 | |
| isolation of a cured strain from corynebacterium diphtheriae pw8. | a nonlysogenic, non-toxinogenic strain was isolated from the pw8 strain of c. diphtheriae by two-step ultraviolet induction. this strain was lysed by phages derived from the pw8 strain but not by beta phages from the c7(beta) strain. when this cured strain was lysogenized with phages from the pw8 strain, toxin production by the resulting lysogens was about a half or a quarter of that of the parent strain pw8. | 1979 | 115787 |
| characterization of a screening test for diphtherial toxin antigen produced by individual plaques of corynebacteriophages. | a passive immune hemolysis assay has been developed to detect diphtherial toxin produced in individual plaques of tox+ corynebacteriophages. this assay permits rapid screening of large numbers of corynebacteriophages for their ability to code for diphtherial toxin or related antigens. the specificity of the assay and its potential usefulness for genetic studies of toxinogenesis have been demonstrated with well-characterized tox+ and tox- laboratory strains of corynebacteriophages. | 1979 | 115898 |
| [effect of the degree of culture aeration on diphtheria toxin production and growth of 3 variants of corynebacterium diphtheriae pw 8]. | 1979 | 116098 | |
| erythromycin and clindamycin resistance in corynebacterium diphtheriae from skin lesions. | erythromycin- and clindamycin-resistant corynebacterium diphtheriae isolates were recovered from skin lesions. resistance to erythromycin and clindamycin was induced by a subinhibitory concentration (0.03 microgram/ml) of erythromycin. clindamycin (0.07 microgram/ml) was a more effective inducer of its own resistance than of erythromycin resistance. erythromycin-inducible cross-resistance to vernamycin b alpha was demonstrated in disk diffusion tests. | 1979 | 117748 |
| non-toxigenic corynebacterium diphtheriae causing subacute bacterial endocarditis: case report. | this is the case report of a 13-yr-old european child from a boarding school at herberton, on the atherton tableland, who developed subacute bacterial endocarditis, with 6 blood cultures at different times growing a non-toxigenic strain of corynebacterium diphtheriae. | 1979 | 118422 |
| effect of metal ions on diphtheria toxin production. | the effect of several metal ions on the production of diphtheria toxin was tested. by using the gel immunodiffusion system for detecting toxin, a wide range of metal ion concentrations was conveniently surveyed. five divalent cations, fe2+, cu2+, co2+, ni2+, and mn2+ inhibited toxin production within a range of concentrations that did not inhibit growth of the producing strain. growth and toxin production were inhibited at identical concentrations by both cd2+ and zn2+, whereas al3+ and sr2+ aff ... | 1979 | 118927 |
| ige synthesis in man. ii. comparison of tetanus and diphtheria ige antibody in allergic and nonallergic children. | 1979 | 107210 | |
| bactericidal effects of anesthetics. | 1979 | 107831 | |
| [testing of a system of unidirectional serologic reactions for detection of diphtheria antigens and antibodies]. | 1979 | 106599 | |
| [a leg ulcer from the tropics caused by corynebacterium diphtheriae?]. | 1979 | 104183 | |
| [use of microbial cells of corynebacterium diphtheriae for preparing a nutrient medium]. | nutrient media prepared on the basis of microbial cells (corynebacteria diphtheriae) proved to be no less nutrient in comparison with conventional media prepared on the full-value food products. use of diphtheria bacilli (by-products of diphtheria toxoid production) as the basis for nutrient media permitted to use up to 30% less food products for this purpose. | 1979 | 105520 |
| prevalence of corynebacterium diphtheriae in pyoderma and other skin lesions. | 1979 | 120849 | |
| method for quantitating sensitivity to a staphylococcal bacteriocin. | a convenient method for quantitating the sensitivity of large numbers of bacterial strains (presently corynebacterium diphtheriae) to a staphylococcus aureus phage type 71 bacteriocin is described. | 1979 | 121117 |
| [septic arthritis due to a nontoxigenic diphtheria bacillus]. | septic arthritis of the hip in a 2 year old child is described. a nontoxigenic diphtheria bacillus was isolated in large numbers from the articular fluid. the same organism was isolated from excoriated skin lesions of the toes. the bacteriology, epidemiology and pathology of the infection are discussed. | 1979 | 122141 |
| diphtheria carriers in manchester: simultaneous infection with toxigenic and non-toxigenic mitis strains. | a toxigenic strain of corynebacterium diphtheriae mitis was isolated from a 10-week-old baby with membranous tonsillitis, and over the next 6 months thirty-nine symptom-free carriers of nitrate-positive mitis strains were found. all carriers were cleared by 14 days' treatment with erythromycin, though several relapsed after a 5-day course. four contacts carried both toxigenic and non-toxigenic mitis strains; epidemiological evidence and phage studies suggest that these had a common origin. these ... | 1980 | 6101751 |
| toxigenic and non-toxigenic corynebacterium diphtheriae. | 1980 | 6102650 | |
| the search for antiviral agents among corynebacteria. | extracts of strains of corynebacterium diphtheriae var. mitis avirulent, c. hofmannii, c. xerosis, c. parvum and an unidentified corynebacterium species were tested for antiviral activity against laboratory strains of echovirus type 11, adenovirus type 2 and vaccinia, and a recent isolate of herpes simplex virus. unlike a previous study, no appreciable antiviral activity was detected in the extracts tested | 1980 | 6108068 |
| [growth stimulator for diphtheria bacteria]. | 1980 | 6157893 | |
| [use of the aggregate hemagglutination method for determining cholera vibrio neuraminidase]. | the suitability of the aggregate hemagglutination test for neuraminidase determination in biological fluids has been evaluated. this test allows one to determine neuraminidase at a concentration of 2--4 mg/ml. the sensitivity of this test is more than 2 orders higher than that of gel diffusion technique and the thiobarbituric assay. the test has revealed that neuraminidase produced by vibrio cholerae is not immunologically related to other kinds of neuraminidase produced by corynebacterium dipht ... | 1980 | 6160701 |
| precursor in cotranslational secretion of diphtheria toxin. | by extracellular labeling of peptides of intact corynebacterium diphtheriae, followed by fractionation of the cells and chain completion by isolated polysomes, it is shown that diphtheria toxin is formed and secreted cotranslationally by membrane-bound polysomes; free polysomes from none. moreover, when the chains on these polysomes were completed in vitro, in the absence of membrane they were found to include not only diphtheria toxin of a molecular weight of 62,000, but also a larger precursor ... | 1980 | 6243620 |
| plasmids in corynebacterium diphtheriae and diphtheroids mediating erythromycin resistance. | plasmids were isolated from erythromycin-resistant corynebacterium diphtheriae and skin coryneforms. six erythromycin-resistant c. diphtheriae strains, isolated from cutaneous lesions, all contained a 9.5-megadalton (mdal) plasmid. loss of resistance was associated with the deletion of a 1-mdal segment from the plasmid or, less frequently, with loss of the plasmid. two erythromycin-resistant diphtheroids were isolated from similar skin lesions. one contained a 38-mdal plasmid that was lost in th ... | 1980 | 6255866 |
| immunological surveys of diphtheric antitoxic antibodies in some african and asian countries. | immunological surveys of diphtheric antitoxic antibodies confirmed the existence of a high circulation of corynebacterium diphtheriae in some african and asian countries. the high immunity level in early childhood confirms the well known fact that other forms of diphtheria, in particular the cutaneous forms, participate in the formation of antitoxic antibodies. immunological surveys can determine relatively exactly the extent of risk of infection in the separate age groups and thus delimit the r ... | 1980 | 6447173 |
| some aspects of phage typing of diphtheria microbes in epidemiological practice. | 1980 | 6450800 | |
| profile analysis of total mycolic acids from skin corynebacteria and from named corynebacterium strains by gas-liquid chromatography and gas-liquid chromatography/mass spectrometry. | gas-liquid chromatography (g.l.c.) was investigated as a potential tool in the classification and identification of cornyebacterium strains isolated from human skin, on the basis of the g.l.c. profile of the trimethylsilyl derivatives of their mycolic acid methyl esters. the g.l.c. patterns of five skin corynebacteria were compared with those of reference strains corynebacterium diphtheriae pw8 and corynebacterium xerosis nctc 9755 and nctc 7929. further compositional information was obtained by ... | 1980 | 6767807 |
| [natural variability of mycobacteria and related organisms]. | 1980 | 6768404 | |
| toxicity of diphtheria toxin-related proteins produced by suppression of nonsense mutations. | the mr = 62,000 diphtheria toxin-related proteins produced from the suppression of nonsense mutations within the tox gene of corynephage beta were purified by affinity chromatography. except for the toxin 111-sup2-62, the mr = 62,000 polypeptides were found to have the same specific toxicity as does wild type toxin. 111-sup2-62 was found to have a prolonged lag period prior to the onset of inhibition of protein synthesis and adp-ribosylation of elongation factor 2. 111-sup2-62 differs from wild ... | 1980 | 6776122 |
| superinfection exclusion by heteroimmune corynebacteriophages. | superinfection of corynebacterium diphtheriae c7(beta) by heteroimmune phage gamma is productive, whereas superinfection by gamma-bin mutants is for the most part nonproductive. exclusion of gamma-bin phage occurred after its dna had penetrated and was partially expressed in the heteroimmune lysogen. all of the infected cells were killed, and lysis was observed. the beta inhibitor causing exclusion was produced during the prophage state and appeared to be distinct from immune repressor. the abil ... | 1980 | 6776290 |
| [diphtheria immunity and the epidemiological situation in the kielce district]. | 1980 | 6776591 | |
| [comparative evaluation of method of preparing diphtheria antibody diagnostic media using erythrocytes]. | 1980 | 6778024 | |
| [protective somatic antigen of corynebacterium diphtheriae]. | deoxycholate c. diphtheriae extract was separated into fractions differing in the size of their molecules. correlation between the molecular weight of each fraction, its specific protein content and its immunogenicity was observed. the high-molecular fraction (mol. wt. exceeding 300,000 daltons) was shown to be the protective somatic antigen of c. diphtheriae. | 1980 | 6778025 |
| radioimmunoassay of arthrobacter neuraminidase: applications to catalytic and taxonomic studies. | 1980 | 6779664 | |
| immunogenic correlation between cross-reacting material (crm197) produced by a mutant of corynebacterium diphtheriae and diphtheria toxoid. | the in vivo immunizing potency of diphtheria toxoid and formalin-treated corss-reacting material (crm197, a nontoxic mutant protein) was compared in guinea pigs. major antigenic differences between the two untreated proteins were also tested in rats. the results showed that diphtheria toxoid and crm197 were equally effective immunogens, but only if the latter was treated with formalin in the same concentration (0.7% vol/vol) was that of the toxoid. formalin treatment rendered the antigens more r ... | 1980 | 6780629 |
| simple procedure for purification of diptheria toxin and separation of its fragments by hydrophobic chromatography. | 1980 | 6781376 | |
| [immunity to diphtheria in advanced cancer patients]. | in expectation of a possible anticancer treatment with diphtheria toxin, the antidiphtheria immunity has been tested on 65 advanced cancerous patients. the test has been carried out by schick's test and by blood antibodies' dosage effected by a process "in vivo" on the depilated skin of the new zealand rabbit. the results show that about the 30% of these patients has no antidiphtheria immunity. the remaining 70% has antidiphtheria immunity, even if in half cases the antibody level is lower than ... | 1980 | 6783052 |
| counter immunoelectrophoresis for rapid testing of toxin producing corynebacterium diphtheriae. | 1980 | 6785212 | |
| immunization status of school children. | 1980 | 6785226 | |
| an improved method for obtaining homogeneous and stable suspension of c. diphtheriae for bacterial agglutination. | 1980 | 6788014 | |
| slide agglutination assay in the c. diphtheriae identification. | 1980 | 6788015 | |
| diphtheria: studies on the biology of an infectious disease. | 1980 | 6813290 | |
| [demonstration of a method of passive microhemagglutination for the titration of antidiphtheria antibodies]. | 1980 | 6821476 | |
| cotranslational secretion of diphtheria toxin and alkaline phosphatase in vitro: involvement of membrane protein(s). | crude messenger ribonucleic acid fractions isolated from corynebacterium diphtheriae and escherichia coli were translated in an e. coli in vitro protein-synthesizing system and yielded precursors of the secreted proteins diphtheria toxin and alkaline phosphatase, respectively. addition of inverted e. coli inner membrane vesicles to the system during the initial stages of translation resulted in the intravesicular segregation of mature diphtheria toxin and alkaline phosphatase. outer membrane ves ... | 1980 | 6988404 |
| diphtheria in jordan: a diminishing yet important paediatric disease. | twenty-seven cases of diphtheria (15 male, 12 female) admitted over a 2-year period, 1977-1978, at the jordan university hospital were reviewed. the majority were admitted during autumn and were in the 2-9-year age group. eleven patients were not vaccinated and six were questionably vaccinated; of these seven died. in 10 patients who were partially or completely vaccinated, only one died. antitoxin was given to 23 patients at varying intervals after the onset of the disease. no antitoxin was giv ... | 1980 | 7381985 |
| [tonsils in diphtheria and the corynebacterium diphtheriae carrier state]. | investigations of 16 archive autopsy observations of diphtheria of the fauces confirmed bacteriologically revealed that corynebacteria diphtheriae multiplied mainly on the surface of the mucous membrane. fibrinous inflammation on the tonsillar surface is most typical for this agent. in all cases with manifestations of acute inflammation the lesion was caused by c. diphtheriae in combination with other bacteria, most frequently streptococci. the latter were harboured deep in the tonsills and caus ... | 1980 | 7406725 |
| infective endocarditis due to corynebacterium diphtheriae: report of a case and review of the literature. | 1981 | 6893847 | |
| [evaluation of the fluorescence for the identification of corynebacterium diphtheriae in patients with diphtheria]. | 1981 | 6808630 |