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a placental view of the diagnosis and pathogenesis of congenital listeriosis. 1977411374
listeria monocytogenes infection after renal transplantation.listeria monocytogenes infection has been observed in 13 patients, of a group of more than 700 renal transplants, treated during the past 13 1/2 years. the infection usually was manifested as bacteremia or meningitis. twelve of the 13 patients survived the infection; one died of brain-stem herniation due to increased intracranial pressure. the recommended treatment is intravenously given ampicillin sodium.1977411435
listeria monocytogenes endocarditis. 1977411437
effect of space flight on cell-mediated immunity. 1977411470
[infections of newborn infants. crucial points and trends]. 1977411722
potentiation of mouse peritoneal macrophage antibacterial functions by treatment of the donor animals with the methanol extraction residue fraction of tubercle bacilli.administration to inbred mice of the methanol extraction residue fraction of tubercle bacilli by some, but not by all, routes affected markedly the in vitro phagocytic and antibacterial capacities of their peritoneal macrophages harvested several days to weeks after treatment. phagocytosis of living [3h]thymidine- labeled staphylococcus albus and staphylococcus aureus organisms, but not of listeria monocytogenes, was markedly enhanced. uptake of the deoxyribonucleic acid precursor thymidine by t ...1977411756
[a case of sepsis and meningitis infected with listeria monocytogenes type 2 (author's transl)]. 1977411856
host resistance to the lvs strain of francisella tularensis in bcg vaccinated mice. 1977411926
enhanced resistance to listeria monocytogenes in splenectomized mice.mice infected with live listeria monocytogenes intravenously from 1 week to 3 months following splenectomy exhibit greatly enhanced antibacterial resistance to this micro-organism as compared to normal or sham-splenectomized mice. they survive a dose of listeria 100 times higher than is the ld50 of this parasite for normal mice. initially, the same number of viable micro-organisms lodge in the livers of splenectomized and normal hosts. however, within 24 h after infection, the number of viable l ...1977412778
anomalous high native resistance to athymic mice to bacterial pathogens.congenitally athymic (nude) mice exhibited an anomalous high resistance against infections with the facultative intracellular parasite listeria monocytogenes and other bacterial pathogens. protection against lethal infection was demonstrated to result from the presence of naturally occurring activated macrophages in the reticuloendothelial organs of the nude mice. this was exemplified after intravenous challenge by enhanced bacterial clearance from the blood and augmented bacterial killing in th ...1977412787
hyperthermia and human leukocyte functions: effects on response of lymphocytes to mitogen and antigen and bactericidal capacity of monocytes and neutrophils.it has recently been demonstrated that fever, or hyperthermia, results in enhanced survival of lizards infected by aeromonas hydrophila. in the present study, the effects of hyperthermia on certain immune functions were assayed in vitro with purified human leukocytes. lymphocyte transformation responses to the mitogen phytohemagglutinin and the common antigen streptokinase-streptodornase were enhanced at 38.5 degrees c relative to 37 degrees c whether analyzed according to absolute counts per mi ...1977412788
immunofluorescent identification of listeria monocytogenes.a fluorescent antibody technique for the rapid diagnosis and identification of l. monocytogenes in smears, impression smears from tissues of animals dead from listeriosis, and in meat and milk is described. the technique could well be exploited for detecting l. monocytogenes in meat and meat products, animal tissues, and in milk provided that it is supplemented with adequate controls. the technique has been compared with conventional cultural technique and found to be superior as far as the time ...1977413282
[certain data on the protoplast ultrastructure].a study was made of the structure of bac. subtilis and listeria monocytogenes protoplasts by the method of scanning electron microscopy. the mechanism of protoplast formation in gram-positive bacteria and in spheroplasts of gram-negative bacteria proved to differ. a loss of the rigid form of the cell, round protrusions on cell surface, and an escape of the cytoplasm through the ruptured cell wall in some one place was noted in case of protoplasts. individual cells can coalesce with one another w ...1977413293
listeric septicaemia in sheep associated with tick-borne fever (ehrlichiosis ovis). 1977413348
cellular mechanisms in the protection against infection by listeria monocytogenes in mice.listeria monocytogenes, in doses of 2-0 x 10(3) to 3-0 x 10(3) viable organisms, was injected into athymic nude mice, irradiated mice and mice treated with reticuloendothelial system-blocking agents. viable counts on liver and spleen homogenates were made at intervals after infection. in both nude mice (nu/nu) and normal littermates (nu/+) of balb/c background, the bacteria grew rapidly for 24 h but increased only slowly thereafter, to reach a plateau of about 10(5) per organ at 72 h. in nu/+ mi ...1977302322
listeria monocytogenes endophthalmitis.a 62-year-old white man developed an acute anterior chamber inflammation in his left eye. listeria monocytogenes was cultured from the vitreous aspirate. there was no evidence for ocular trauma or distant site of infection from which hematogenous spread of the organism occurred. no underlying state of immunocompromise was demonstrated. the endophthalmitis responded well to therapy.1977302649
antimicrobial spectrum, pharmacology and therapeutic use of antibiotics. part 2: penicillins.the mechanism of action, resistance, antibacterial spectrum, clinical pharmacology, adverse effects, and therapeutic and prophylactic use of penicillins are reviewed. the choice of a penicillin is discussed. the only indication for the penicillinase-resistant penicillins is the suspected or demonstrated presence of staphylococcus aureus. there are no important differences in therapeutic effect among oxacillin, cloxacillin, dicloxacillin or flucloxacillin by the oral route, or among oxacillin, di ...1977318800
infection in infants and children.infection with listeria monocytogenes is demonstrated over a 141/2 year period in 24 newborns, three infants 1 to 2 months of age, and two children. comparison of the 22 cases of listeria meningitis in newborns with 118 cases of neonatal meningitis due to other bacteria indicates a later onset of symptoms in cases of listeria meningitis with a more favorable outcome than with most other agents. treatment with ampicillin sodium appears effective. monocytic cell increases in peripheral blood or cs ...1977322473
corynebacterium equi infection complicating neoplastic disease.corynebacterium equi, a soil-residing diphtheroid pathogenic in horses, swine and cows, caused pulmonary infection with bacteremia in two patients with lymphomas. both patients were being treated with immunosuppressive therapy, as were the patients in three previously reported human cases. unless certain characteristics of these organisms are recognized, they may be regarded as normal flora or contaminating diphtheroids. they could also be mistaken for other gram-positive rods, such as bacillus ...1977326031
[new serovariants and/or antigen combinations of listeria monocytogenes (author's transl)].in 2111 samples of human faeces originating from 932 persons (midwives, pregnant women, slaughterhouse workers, laboratory workers, individuals with gastroenteritis and without specific symptoms) a total of 86 (9.22%) carriers of l. monocytogenes could be found. serotyping revealed prevalence of serovar 1/2a (39%) which was characterized by beta-hemolysis and mouse pathogenicity; serovar 4b and 5, also showing beta-hemolysis and mouse pathogenicity, were met with in 11% and 2% of cases, respecti ...1977414480
listeria monocytogenes meningitis: case report.a case of listeria monocytogenes septicaemia with meningitis is described. predisposing factors in this case included chronic liver disease, diabetes mellitus and liver malignancy. the infection responded poorly to ampicillin.1977415268
effect of bcg and c. parvum on in vivo listeria clearance and tumor growth. comparative studies in normal and congenitally athymic (nude) mice.clinically, it is important to know whether agents used for immunostimulation require the presence of functional thymus-derived (t) cells. previous studies showed that both bcg and c. parvum induced a macrophage-dependent enhanced in vivo listeria clearance and in vivo inhibition of a fibrosarcoma induced by 20-methylcholanthrene. these two models were re-evaluated in congenitally thymusless (nude or nu/nu) b10lp mice lacking functional t cells. in nu/nu mice, (1) bcg failed to enhance listeria ...1977415917
proposals for quality control methods of bacterial vaccines for immunostimulation. iii. effect of bcg and c. parvum on in vivo listeria clearance and tumor growth.two quality control methods for bcg and c. parvum are described. first, in vivo macrophage dependent-spleen clearance of listeria monocytogenes in inbred b10lp mice. bcg and c. parvum were administered intravenously prior to listeria inoculation (a prophylactic model). conditions for enhanced listeria clearance including dose, route and time interval were described for each vaccine. next, a tumor model was developed: i.e. a fibrosarcoma, chemically induced by 20-methylcholanthrene in inbred balb ...1977415924
enhanced primary resistance to listeria monocytogenes in t cell-deprived mice. 1977415965
[increased resistance in mice to listeria monocytogenes after treatment with a fraction from an inflammatory granuloma].the multiplication of listeria monocytogenes in the spleen was decreased between the 3rd and the 11th day following the inflammatory reaction induced in mice by subcutaneous implantation of talc embedded in a calcium phosphate gel into the dorsal area. a similar activity was observed after injection of so4 (nh4)2 fractionated extracts from granuloma. the major activities were found in the 33% saturation precipitate and in the 80% saturation supernatant.1977417840
[different courses of listeria monocytogenes infection in canaries]. 1977557974
listeria monocytogenes infection in an immunosuppressed patient. 1977847965
[influence of latent vitamin a deficiency of the mouse on the production of humoral antibodies against sheep erythrocytes and on the resistance against infection with listeria monocytogenes (author's transl)].mice fed with a vitamin a free diet for several months did not develop signs of vitamin a deficiency. however, chemical analysis revealed a reduced content of vitamin a in the liver of such mice. the ability of these animals were latent vitamin a deficiency to produce antibodies against parenterally applicated sheep erythrocytes was not hampered. similar numbers of antibody producing cells could be detected in the spleen of these mice compared with control animals. resistance against intravenous ...1977848214
infection in newborn siblings.two newborn siblings, one with meningitis and one with sepsis due to listeria monocytogenes, were born to a healthy, 33-year-old woman. she had had a spontaneous abortion prior to the birth of these infants. in spite of negative cultures, persistence of this bacterium in the mother's genital tract and perinatal acquisition of infection is suspected.1977848461
a numerical taxonomic survey of listeria and related bacteria.a numerical taxonomic study was performed on named strains of listeria, erysipelothrix, microbacterium thermosphactum, lactobacillus, streptococus, propionibacterium, kurthia and some possibly related bacteria using i43 unit characters covering a wide range of properties. the strains fell into six main clusters: (a) listeria; (b) microbacterium thermosphactum, lactobacillus, streptococcus; (c) gemella, erysipelothrix; (d) kurthia and mainly aerobic corynebacteria; (e) propionibacterium, staphylo ...1977856940
cell-mediated immunity after oral immunization with ribonucleic acid-protein fractions of vibrio cholerae l-form lysates.oral administration of a single dose of ribonucleic acid-protein fraction of lysates of vibrio cholerae subtype ogawa l-forms induced an increase in cell-mediated immunity in rabbits. this was demonstrated by an increase in leukocyte migration inhibition in peripheral blood leukocytes, in macrophages migration inhibition, and in microbicidal activity against listeria monocytogenes in peritoneal macrophages obtained from orally immunized rabbits. increased cell-mediated immunity was induced mainl ...1977863514
central nervous system infections in patients with cancer. changing patterns.central nervous system infections in patients with cancer at memorial sloan-kettering cancer center from 1971 to 1974 were surveyed and compared with a previous survey from 1955 to 1970. the two periods were similar in that: 1) there was a high incidence of cns infection in patients with lymphoma, leukemia, and head and spine tumors, 2) specific organisms tended to infect patients with certain primary neoplasms, and 3) fungal infections were common and difficult to diagnose. the two periods diff ...1977880555
influence of cyclophosphamide on delayed hypersensitivity and acquired cellular resistance to listeria monocytogenes in the mouse.the effect of a single dose of cyclophosphamide (cy) on delayed type hypersensitivity (dh) and acquired cellular resistance (acr) to listeria monocytogenes infection in mice was studied. intraperitoneal or intracutaneous immunization with l forms of l. monocytogenes did not result in protection against lethal challenge. a positive dh could be observed when cy-treated mice were intracutaneously immunized with 10(8) or more l forms. intraperitoneal injection of viable l. monocytogenes resulted onl ...1977885586
[neonatal listeriosis. apropos of 53 cases].53 cases of neonatal listeriosis were seen during the last five years at the intensive care unit for newborn infants (pr minkowski) and the neonatal center (p. varangot) of the port-royal maternity hospital. the significant decline in mortality to 22 p. 100, when compared with previous years, was attributed to improvements in the diagnosis during the first hours of life and the contribution of artificial ventilation. the most frequent initial clinical sign was respiratory distress (58 p. 100) wh ...1977903579
effect of listeria monocytogenes septicemia during pregnancy on the offspring. 1977910831
listeria monocytogenes endocarditis in hypertrophic cardiomyopathy. 1978565238
bacterial endocarditis due to listeria monocytogenes in a pregnant diabetic.a case of bacterial endocarditis due to listeria monocytogenes in a pregnant, class d diabetic patient is presented. the importance of obtaining proper cultures and instituting appropriate antibiotic therapy promptly is emphasized. a favorable outcome was achieved in spite of the combined risk to the fetus of maternal diabetes and listeria endocarditis.1978618485
chronic active hepatitis, haemolytic anaemia and listeria monocytogenes bacteraemia.the association of chronic active hepatitis with haemolytic anaemia is well known. both conditions may respond to steroid therapy which, in common with other causes of suppressed t-lymphocyte function, predispose to many types of infection. a case is described in which transient listeria monocytogenes bacteraemia occurred and the patient recovered without antimicrobial therapy.1978625461
prosthetic-valve endocarditis due to listeria monocytogenes.clinical and necropsy observations in the case of a patient with prosthetic-valve endocarditis due to listeria monocytogenes are presented. although rare cases of l. monocytogenes infection of natural cardiac valves have been reported, this represents the first known case of infection of a prosthetic cardiac valve by this organism.1978629227
enumeration and ultrastructure of c4-producing free alveolar cells from guinea pig lung.free alveolar cells from guinea pig lung producing the fourth emoponent of c (c4) were identified, enumerated, and characterized by using anti-c4 fab-peroxidase conjugates in conjunction with transmission electron microscopy. the c4-producing cell population consisted of: 1) alveolar macrophages (am); 2) less well differentiated phagocytes similar in morphology to exudate macrophages; and 3) weakly phagocytic secretory cells with numerous profiles of rough-surfaced endoplasmic reticulum (er). in ...1978632583
listeria monocytogenes infection with brain abscess formation--the first case in miyagi prefecture.a rare type of brain abscess formation caused by infection with listeria monocytogenes was observed in a 2-year-old boy. the patient did not respond to treatment with various antibiotics. the isolated organisms were found to be sero-type 4b. this is the first report of listeria monocytogenes infection in miyagi prefecture.1978635896
[listeria monocytogenes meningitis in the newborn and contamination in the maternity ward]. 1978637672
[carrier state of listeria monocytogenes bacilli in pregnancy]. 1978640487
reversion of dextran sulfate-induced loss of antibacterial resistance by bordetella pertussis.parenteral injection of dextran sulfate 500 (ds 500; 50 mg/kg of body weight) into mice caused a complete loss of resistance to a sublethal (2 x 10(3) to 5 x 10(3)) infection with listeria monocytogenes. such loss could be prevented by pretreatment of animals with 3 x 10(9) heat-killed bordetella pertussis organisms (po) 5 to 30 days before the administration of ds 500. the increased phagocytic capcity induced by po was only exhausted when a fourfold dose of ds 500, effecting complete loss of an ...1978640739
changes in host resistance caused by nocardia brasiliensis in mice: cross-protection against listeria monocytogenes.listeria monocytogenes was used to study the rate of development, magnitude, and persistence of the antimicrobial resistance engendered by nocardia brasiliensis infection in mice. the growth of listeria in the liver and spleen was more effectively restricted in nocardia-infected mice than in noninfected animals. the development of delayed-type hypersensitivity to the nocardia antigen was closely correlated to the increased resistance to listeria, suggesting that both properties are the consequen ...1978640748
suramin effects on macrophage phagolysosome formation and antimicrobial activity.the effects of suramin on phagolysosome formation and antimicrobial activity of mouse peritoneal macrophages cultivated in vitro have been studied. prolonged in vitro pretreatment of macrophages with high concentrations of suramin caused macrophages to form large fragile phagolysosomes in which the concentrations of the various lysosomal enzymes were inferred to be diminished. in addition, suramin-treated macrophages demonstrated enhanced exocytosis of acid phosphatase during phagocytosis of pol ...1978669808
neonatal listeria monocytogenes meningitis. a case report.the clinical presentation, bacteriological results, treatment, and outcome of listeria monocytogenes meningitis in a newborn infant are described. the neonatal listeriosis was of the late-onset variety, and the infant survived the infection, but hydrocephalus, which necessitated operative relief, developed. although 2 cases of listeria meningitis have previously been described in south africa, and opportunistic listeriosis is known to occur here, this is apparently the first documented case of n ...1978675389
listeria monocytogenes causing hospital-acquired enterocolitis and meningitis in newborn infants. 1978678926
[further observations on human infection by listeria monocytogenes].two cases of isolation of listeria monocytogenes type 1 from vaginal mucus of two pregnant women who underwent premature deliveries with death of foetuses are described.1978728263
[growth of some pathogenic microorganisms on chemically defined media which were proposed for sensitivity testing (author's transl)].the growth of 16 bacterial cultures, which belong to the frequently encountered pathogens, in three different chemically defined fluid media was investigated through turbidity measurements in comparison with mueller-hinton-broth. e. coli, salm. dublin, salm. typhi-murium, enterobacter cloacae, proteus mirabilis, pseud. aeruginosa and bac. cereus grew in two of the three tested defined media with approximately the same intensity as in the mueller-hinton broth. staph. aureus grew well only in one ...1978730218
listeria pneumonitis: induction of immunity after airborne infection with listeria monocytogenes.after implantation of approximately 10(3) listeria monocytogenes organisms into the lungs, mice develop an acute pneumonitis with dissemination of infection to a mediastinal lymph node (medln), liver, and spleen. the infections in a medln and spleen resolve in approximately 7 days, but the lung infection persists for a few days longer. pneumonitis is accompanied by a lymphoproliferative response in a medln and spleen, and immunity to listeria is conferred adoptively with medln and spleen cells b ...1978730382
[internuclear ophthalmoplegia in infectious encephalitis: observation on a case of listeriosis].an internuclear ophthalmoplegia was diagnosed and recorded electro-oculographically in a patient with pontomedullary listeriosis. the etiological differential diagnosis in case of internuclear ophthalmoplegia is discussed. it is emphasized that listeria monocytogenes encephalitis should be considered because this pathology may be electively located in the pontomedullary area and because of the encreasing frequency of human listeriosis.1978754276
three phases of phagocyte contribution to resistance against listeria monocytogenes. 1978418145
further characterization of listeria monocytogenes serotype 5.fifteen strains of listeria monocytogenes serotype 5 were characteriized for carbohydrate utilization, enzymic reactions, and other differential criteria. hemolytic patterns were tested on ovine, bovine, equine, human and lapine blood agars. results were compared with those of previously reported strains of l. monocytogens serotype 5.1978418861
impaired chemotactic responsiveness of macrophages from gnotobiotic rats.peptone-induced macrophages obtained from gnotobiotic (gb) rats responded poorly to chemotactic stimuli that have a powerful, attractive influence upon the cells of conventional donors. monocyte recruitment from the circulation into peptone-induced exudates also was impaired in gb subjects. although relatively more resident cells are present in exudates borne by gb donors, their number cannot in itself account for the sluggish response of peptone-induced cells from gb rats. neutrophil accumulati ...1978415979
[case of abortion with positive serologic reaction and positive blood culture for listeria monocytogenes]. 1978416429
in vitro susceptibility of listeria monocytogenes to some antibiotics and their combinations.the listeria monocytogenes strains isolated during recent years in our hospital have been tested for in vitro susceptibility against eleven antibiotics. the following tests were used: antibiotics discs method on mueller-hinton agar, determination of mics by agar dilution method, study of the bactericidal potency of antibiotics combinations. antibiotic discs method gives some too optimistic results, not confirmed by the mics determined with agar dilution method. ther are a few antibiotics used al ...1978416625
listeria encephalitis in five renal transplant recipients.listeria encephalitis has occurred recently in 5 renal transplant recipients at the transplantation unit in stockholm. symptoms from the central nervous system, such as coma, hemiparesis and cranial nerve paresis, dominated the clinical picture. listeria monocytogenes was isolated from the blood of all the patients, from the cerebrospinal fluid in two, from the urine in one and post mortem from the brain in one patient. pleocytosis never exceeded 200 leucocytes/mm3 and the glucose ratio was norm ...1978416653
resistance and susceptibility of mice to bacterial infection: course of listeriosis in resistant or susceptible mice.resistance and susceptibility to listeria monocytogenes in mice was found to be related to (i) the innate ability of the nonimmune macrophages to kill or inhibit the growth of the organism during the first 24 to 48 h after infection, and (ii) the time of onset of acquired cell-mediated resistance. resistant c57bl/6 mice were 10 times more efficient than susceptible balb/c mice at suppressing the early growth of listeria in the liver. furthermore, the onset of acquired immunity occurred 24 to 48 ...1978417029
development of listeria monocytogenes in monoxenic and polyxenic beef minces.the objective of this study was to determine the multiplication possibilities of listeria monocytogenes in beef minces with a defined microflora (gnotoxenic). selective counts were made for each species and each bacterial association for a period of 17 days after inoculation of the axenic meat. the concentration of l. monocytogenes did not increase, but remained constant in monoxenic meats. associated with lactobacillus plantarum, the number of listeria tended to decrease. conversely, in associa ...1978417516
[persistence of listeria monocytogenes in the body of experimentally infected mice]. 1978415454
[mechanism of the changes in the animal reactivity to tularemia in mixed infection].experiments were conducted on albino rats infected with listeria or salmonelloses, and then with tularemia; differences were revealed in the duration of manifestation of nonspecific resistance associated with peculiarities of pathogenesis and immunogenesis of the background infections. one of the significant factors causing an increase of albino rats resistance to tularemia in mixed infection was activation of the immunomorphological reaction promoting accelerated development of specific immunit ...1978415458
listeria monocytogenes and encephalitis. 1978415673
induction of cell-mediated immunity to mycobacterium leprae in mice.the immune response of mice to armadillo-derived, irradiation-killed mycobacterium leprae (i-ml) was investigated. following injection of 100 microgram of i-ml into the left hind footpads of mice, a state of cell-mediated immunity (cmi) was engendered to antigens of m. leprae. the evidence for cmi was as follows: (i) development of delayed-type hypersensitivity to both human tuberculin purified protein derivative and soluble m. leprae antigens; (ii) t-lymphocyte-dependent macrophage activation a ...1978415009
a case of listeriosis in pregnancy with fetal survival.listeriosis during pregnancy is generally considered to result in an intrauterine infection which affects the fetus before birth or in the perinatal period. a case of listeriosis in a 38-yr-old diabetic woman with an influenza-like disease in her 32nd wk of pregnancy is presented. two successive blood cultures were positive for listeria monocytogenes type 4b and her serum showed a rising titer for agglutinins to this organism. after antibiotic treatment of the patient she gave birth to a healthy ...1978264070
activation of reticuloendothelial system macrophages and enhancement of host resistance to a transplantable osteogenic sarcoma in mice by an extract of brucella abortus.an aqueous-ether extract of brucella abortus, bru-pel, enhanced resistance of mice to a transplantable osteogenic sarcoma (ogs). the results presented in this report suggest that bru-pel is an effective immunomodulator and that one mechanism through which it enhances host resistance is activation of phagocytic cells of the reticuloendothelial system. peritoneal macrophages from mice inoculated with bru-pel 14 days previously were cytotoxic for ogs cells in vitro, limited the multiplication of va ...1978282007
listeria infection in transplant patients. five cases and a review of the literature.we report five cases of listeria monocytogenes infection in renal transplant patients at the university of minnesota and compare them to 15 additional patients reported on in the united states literature. all patients were noted to have fever, malaise, and nonspecific symptoms of infection. there were no consistent diagnostic laboratory findings except for positive bacteriologic studies. successful treatment consisted of intravenous penicillin g potassium in most cases (ampicillin sodium was req ...1978339878
qualitative study of paradoxical zone phenomenon of penicillins against 17 bacterial species of clinical importance.using a triple agar layer technique and enzymatic inactivation of penicillin, the occurrence of a paradoxical zone phenomenon (illustrated by a typical 'target' image around the reservoir of antibiotic) was determined for several bacterial species specially chosen with regards to their taxonomic position, clinical importance and penicillin susceptibility. among gram-positive bacteria, a paradoxical zone was obtained for approximately 43% of the strains studied here (all 10 strains of staphylococ ...1978340171
nonspecific immunostimulant activities of synthetic trehalose-6,6'-diesters (lower homologs of cord factor).mycobacterial cord factors (6,6'-diesters of trehalose with mycolic acids ranging from c80 to c90) have been shown to protect mice effectively against infection with klebsiella pneumoniae or with listeria monocytogenes. our present findings indicate that the low-molecular-weight cord factor of corynebacterium diphtheriae (with corynomycolic acids ranging from c28 pto c36) is equally active. moreover, its synthetic analog (with synthetic c32 mycolic acid) has the same activity. two lower syntheti ...1978352926
specific and nonspecific resistance in mice immunized with irradiated myobacterium leprae.following subcutaneous inoculation of irradiated mycobacterium leprae (i-ml) into the left hind footpad of mice, there was increased resistance to listeria monocytogenes, indicative of macrophage activation, at the immunization site. in spite of the high level of localized macrophage activation which was proportioned to the immunizing dose of i-ml, no such activity could be demonstrated systemically in these mice, as evidenced by the absence of increased resistance to an intravenous challenge wi ...1978352954
chorio-meningo-encephalitis due to listeria monocytogenes after renal transplantation.a 35-year-old man, who underwent renal transplantation, died of meningo-encephalitis with symptoms of meningitis for only 8 days. the autopsy revealed marked chorio-meningo-encephalitis caused by listeria monocytogenes. this report on listeriosis in renal transplant patients is the second in our country, where adult cases of listeriosis are rare. recent knowledge about listeriosis in renal transplants is reviewed and discussed.1978362022
resistance and susceptibility of mice to bacterial infection: genetics of listeriosis.a survey of various strains of mice showed distinct differences in resistance or susceptibility to listeria monocytogenes. c57b1, related sublines, nzb, and sjl were resistant to listeria, whereas balb/c, cba, a, dba/1, c3h, lp.riii, 129, and wb were susceptible. the gene(s) responsible for resistance and susceptibility to listeria were studied in detail. c57bl6/6, b10.d2, and b10.a mice were 100 times more resistant than were balb/c, cba, and a. resistance of the (c57b1/6 x balb/c)f1 was interm ...1978305895
transfer of immunity against listeria monocytogenes by t cells purified by a positive selection technique.affinity columns prepared with rabbit antibody to the f(ab')(2) fragment of rat immunoglobulin were used to separate rat thoracic duct lymphocytes into sub-populations that differ with respect to the density of their surface membrane immunoglobulin. using this technique, it was shown that lymphocytes in the dna synthetic (s) phase of the mitotic cycle are added in increased number to the lymph of rats infected with listeria monocytogenes. the great majority of these s-phase cells lacked a high d ...1978310423
["listeria monocytogenes" isolation from a urine specimen of a subject with repeated abortions (author's transl)]. 1978111630
rifampicin against experimental listeriosis in the mouse.the activity of rifampicin was compared with that of tetracycline, ampicillin, penicillin g, chloramphenicol, gentamicin and sulphadiazine in vitro and in experiments on mice infected with various strains of listeria monocytogenes. although the minimum inhibitory concentration of rifampicin was not appreciably lower than that of ampicillin, penicillin g and gentamicin, rifampacin was very much more active in vivo than any of these antibiotics. one of the reasons for its greater efficacy may be t ...1978413697
listeriosis in an arabian foal with combined immunodeficiency.a 1-month-old arabian foal with signs of central nervous system disease was found to have combined (b- and t-lymphocyte) immunodeficiency. the foal died in spite of intensive antibiotic therapy. at necropsy, generalized lymphoid hypoplasia and acute necrotizing and granulomatous inflammation of the brain, heart, and adrenal glands were found. in addition, there were spinal meningitis and focal hepatic necrosis. listeria monocytogenes was isolated on primary culture from the brain.1978413818
[incidence of listeria monocytogenes in the intestinal contents of broilers on different farms (author's transl)].the intestinal contents of 3,090 broilers, one day to five weeks of age, from 1,025 broiler houses, were examined for the presence of listeria monocytogenes. l. monocytogenes was isolated in 243 cases, i.e. 23.7% of the broiler houses, 58.8% were of type 1, 35.5% of type 4b, 1.2% were of type 5 and 2.4% of the strains could not be typed. in spite of cleaning and disinfection after the chickens had been taken to the poultry slaughterhouse, reinfection occurred in the broiler houses in 16.9% of th ...1978414373
[listeria monocytogenes (welshimer strain) application to induce an acquired resistance to listeriosis and mycobacterial infections (author's transl)]. 1978149596
[influence of killed bordetella pertussis cells on the resistance against infection with listeria monocytogenes (author's transl)].the influence of killed bordetella pertussis cells (b.p.) on the cell-mediated resistance of mice against infection with virulent germs of listeria monocytogenes has been studied. resistance of mice was decreased, when 3 x 10(9) b.p. were injected 1 day before, simultaneously with or 1 day after infection, resulting in augmented amounts of viable listeriae recovered from the spleens 3 days after infection (figure 1). the ld50 was strongly reduced (table 1). transfer of immune spleen cells to rec ...1978207050
[epidemiologic and serologic study of listeriosis in man and domestic and wild animals in austria].in the framework of a study aimed to ascertain the possibilities of infection transmission from mother to child the athors examined serologically gravid women for toxoplasmosis and antibodies against listeriosis, using routine methods, in austria in 1974, 1975 and 1975. almost all gynecologists of the region of styria (austrial), who systematically delivered data concerning abortions, premature births and stillbirths, were invited to take part in the study. at the same time data concerning domes ...1978112179
[a case of listeria meningoencephalitis]. 1978116339
role for activated macrophages in resistance against trichinella spiralis.to determine whether activated macrophages are important in resistance against the intestinal phase of nematode parasites, we studied trichinella spiralis infections in mice with normal macrophages and in mice with macrophages activated by either chronic toxoplasma gondii or acute listeria monocytogenes infections. the peak t. spiralis adult worm burden in the intestines of normal c57bl/6 or swiss webster mice occurred from 6 to 14 days after infection. subsequent expulsion of worms from the int ...197899366
listerial prosthetic valve endocarditis. successful medical therapy. 1978100621
[soluble listeria monocytogenes antigen in cerebrospinal fluid]. 1978100765
microbiology problem. 1978101083
acquired cellular resistance, delayed hypersensitivity, and altered macrophage migration in listeria monocytogenes-infected guinea pigs.a listeria monocytogenes infection in guinea pigs was used to study the interrelationship between antigen-induced macrophage migration inhibition, delayed-type hypersensitivity, and acquired cellular resistance. early after infection (at 2 and 7 days), very significant enhancement of macrophage migration was observed. migration inhibition was detected beginning on day 14 and was uniformly observed only on day 21 of the infection, after which a shift again to enhancement was seen. the early detec ...1978101454
correlative ultrastructural and functional study of hamster peritoneal macrophage activation in vitro by lymphokines. 1978101660
listeria monocytogenes endophthalmitis with a black hypopyon.a 68-year-old woman had a marked decrease in visual acuity, increased intraocular pressure, and acute iridocyclitis. she developed a pigmented hypopyon simulating an occult intraocular melanoma. two anterior chamber paracenteses showed growth of listeria monocytogenes. the patient received systemic intravenous penicillin, topical fortified gentamicin sulfate drops, and intraocular injections of cephaloridine. on discharge from the hospital after a two-week stay, visual acuity had improved and in ...1978102203
an attempt at immunotherapy of murine virus erythroleukemia.it was demonstrated that the nonvirulent strain of listeria monocytogenes isolated from vegetable matter prolonged significantly the survival time of mice inoculated with murine virus erythroleukemia. the most significant survival time was recorded when live listeriae were administered on the same day but into another site than the leukemia virus was.1978102689
[meningitis caused by listeria monocytogenes--an autopsy case]. 1978102810
light and electron microscopic study of the livers of pregnant mice infected with listeria monocytogenes.listeria monocytogenes cells were observed in the hepatic cell cytoplasm or in the phagosome at 24 and 48 hours but not at 72 hours after inoculation in pregnant mice. the presence of bacteria initially in a membrane-bound vesicle indicates that the bacteria enter the hepatic cells by endocytosis, resulting in eventual destruction of hepatic cells. characteristic lesions of the liver at 24 and 48 hours after inoculation consist of multiple focal areas of necrosis. the initial neutrophilic reacti ...1978103471
immunity to antigenically related salmonellae: effects of humoral factors on the bactericidal activity of normal and immune peritoneal exudate cells.immunity against salmonella enteritidis and listeria monocytogenes was studied by measuring in vitro the bactericidal activity of peritoneal exudate cells (pec) of control (normal pec) and s. typhi ty2-immune (immune pec) mice. specific immune serum, anti-s. tyhphi ty2, heat inactivated at 56 degrees c for 30 min, significantly inhibited the growth of s. enteritidis only with immune pec. these opsonic factors had no effect upon the activity of normal pec. that such inhibition could not be demons ...1978103836
heat-labile b-cell mitogen obtained from listeria monocytogenes.a water-soluble extract of listeria monocytogenes strain 10403 acts as a mitogen on cultured mouse spleen lymphocytes. this mitogen induced a response six to nine times that of controls, as measured by [3h]thymidine incorporation. the mitogen extract was derived from washed bacterial cells which were mechanically disrupted with a french press. the extract was centrifuged at 105,000 x g and filtered through a 0.22-micrometer filter. similar levels of lymphocyte stimulation were observed in lympho ...1978103837
the macrophage as an antineoplastic surveillance cell: biological perspectives. 1978104035
epidemic listeriosis. report of 14 cases detected in 9 months.during the period august 1977 to april 1978, 14 black patients in johannesburg area had systemic infections caused by listeria monocytogenes. nine of these patients were neonates who presented with septicaemia (5 cases) or septicaemia and meningitis (4 cases) and 5 were adults, all of whom had meningitis. the mortality rate was 43% (6/14), with 4 neonatal and 2 adult deaths. all isolates of l. monocytogenes were type 4b. only sporadic cases of human listeriosis have previously been reported in s ...1978104398
[studies about monocines (author's transl)].by means of mitomycin induction monocine preparations were made from 162 listeria monocytogenes strains. from tested strains of different serovars and antigen combinations altogether 76% were monocinogenic. examination of efficiency was performed against 15 indicator strains of listeria monocytogenes. concluding from spectra of reaction 6 groups of monocines (a-f) could be differentiated. serovar 5 (ivanov) proved as an indicator strain particularly sensitive for all monocines.1978104479
clinical aspects on 64 cases of juvenile and adult listeriosis in sweden.in 1958-74 altogether 64 cases of bacteriologically verified infections of listeria monocytogenes were diagnosed in sweden in children, aged more than 27 days, and in adults. immunosuppression predisposed to the disease. thus, many patients had co-existing disorders, such as leukemia and alcoholism. sixteen patients had been treated with corticosteroids, which were combined with cytostatic drugs in nine. meningoencephalitis was diagnosed in 52 patients and was fatal in 16. the clinical symptoms ...1978104552
stimulation of human b lymphocytes by listeria cell wall fraction.cell wall fraction of listeria monocytogenes (lcwf), a b cell mitogen for mouse spleen cells, is also mitogenic for human adult and cord peripheral blood lymphocytes. purified b-cell suspensions responded to lcwf in vitro proliferation, to a similar extent as the unfractionated suspensions. furthermore, lcwf-induced b cell differentiation into igm-containing cells and their percentage correlated significantly with the extent of lymphocyte proliferation.1978104815
[induction of macrophage activation with bacterial products for potentiation of resistance to some chronic infections].adult mice of the consanguine a2g strain received two intraperitoneal inoculations of 0.5 mg listeria monocytogenes phospholipid extract at 30 days interval. in the treated animals and the controls, the capacity to develop a humoral immune response was tested 24 hours after the second inoculation, following antigenic stimulus with sheep red blood cells; phagocytizing in vitro of labelled germs by peritoneal macrophages and the response of lymphocytes to mitogenic and allogenic stimuli were likew ...1978107569
postnatal development of resistance against infection in an experimental model.the postnatal development of resistance against infection was monitored by the treatment of juvenile mice with a virulent strain of listeria monocytogenes. it could be shown that until day 10 after birth, young mice succumbed to an infection with even minimal doses of bacteria. between day 15 and 30, the resistance against infection gradually increases until the rather constant level of grown-up animals is reached (fig. 1). juvenile mice that survive the primary infection are able to build up a ...1978107682
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