Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| prospective study of chlamydia pneumoniae igg seropositivity and risks of future myocardial infarction. | chlamydia pneumoniae has been hypothesized to play a role in atherothrombosis. however, prospective data relating exposure to chlamydia pneumoniae and risks of future myocardial infarction (mi) are sparse. | 1999 | 10069783 |
| role of innate and adaptive immunity in the outcome of primary infection with chlamydia pneumoniae, as analyzed in genetically modified mice. | infection with chlamydia pneumoniae is a common cause of acute respiratory disease in man and is also associated with atherosclerotic cardiovascular disorder. herein, we have compared bacterial load and immune parameters of c. pneumoniae-infected mice genomically lacking t cell coreceptors, cytokine receptors, or cytotoxic effector molecules. a protective role for cd8+ cells is shown by the enhanced severity of infection of cd8-/- or tap-1-/-/beta2-microglobulin -/- mice. cd8+ cells hindered a p ... | 1999 | 10072530 |
| an epidemic of a pertussis-like illness caused by chlamydia pneumoniae. | between june and july, 1994, we encountered an epidemic of a pertussis-like illness in adolescents in a junior high school located in a rural area of japan. the purposes of this study were to record the clinical manifestations and to identify an etiology. | 1999 | 10093951 |
| antibiotic treatment trials for secondary prevention of coronary artery disease events. | 1999 | 10096927 | |
| randomized secondary prevention trial of azithromycin in patients with coronary artery disease and serological evidence for chlamydia pneumoniae infection: the azithromycin in coronary artery disease: elimination of myocardial infection with chlamydia (academic) study. | chlamydia pneumoniae commonly causes respiratory infection, is vasotropic, causes atherosclerosis in animal models, and has been found in human atheromas. whether it plays a causal role in clinical coronary artery disease (cad) and is amenable to antibiotic therapy is uncertain. | 1999 | 10096928 |
| treatment of helicobacter pylori and chlamydia pneumoniae infections decreases fibrinogen plasma level in patients with ischemic heart disease. | chronic chlamydia pneumoniae and helicobacter pylori infections could be a risk factor for ischemic heart disease (ihd), possibly by increasing fibrinogen levels. the aim of our study was to evaluate changes in fibrinogen level in patients with ihd and h pylori and/or c pneumoniae positivity randomly assigned to antibiotic treatment. | 1999 | 10096930 |
| endothelial cytotoxicity mediated by serum antibodies to heat shock proteins of escherichia coli and chlamydia pneumoniae: immune reactions to heat shock proteins as a possible link between infection and atherosclerosis. | growing evidence suggests that an immunological reaction against heat shock proteins (hsps) may be involved in atherogenesis. because hsps show a high degree of amino acid sequence homology between different species, from prokaryotes to humans, we investigated the possibility of "antigenic mimicry" caused by an immunological cross-reaction between microorganisms and autoantigens. | 1999 | 10096931 |
| epidemiology of chlamydia pneumoniae infection in a randomly selected population in a developed country. | this cross-sectional study of 400 sera from a randomly selected adult population in northern ireland, using a microimmunofluorescence assay, demonstrated high overall seropositivity (70%) for igg chlamydia pneumoniae antibodies in developed populations. seropositivity was shown to be unrelated to gender, age or smoking but there was an inverse trend between infection and educational level achieved as a measure of socio-economic status. igg levels were also higher during the winter months suggest ... | 1999 | 10098793 |
| seroprevalence of igg antibodies to the chlamydia-like microorganism 'simkania z' by elisa. | the newly described microorganism 'simkania z', related to the chlamydiae, has been shown to be associated with bronchiolitis in infants and community acquired pneumonia in adults. the prevalence of infection in the general population is unknown. a simple elisa assay for the detection of serum igg antibodies to 'simkania z' was used to determine the prevalence of such antibodies in several population samples in southern israel (the negev). the groups tested included 94 medical and nursing studen ... | 1999 | 10098794 |
| treatment with the antibiotic roxithromycin in patients with acute non-q-wave coronary syndromes. the final report of the roxis study. | mounting evidence suggests infection, specifically chlamydia pneumoniae, plays a role in atherosclerosis. we tested whether antibiotic treatment with the macrolide roxithromycin improves clinical outcome in patients with acute non-q-wave coronary syndromes. preliminary reports revealed a reduction in events in the roxithromycin group at 30 days. we now report the long-term follow-up results. | 1999 | 10099908 |
| characterization of the koala biovar of chlamydia pneumoniae at four gene loci--ompavd4, ompb, 16s rrna, groesl spacer region. | koalas are infected with two species of chlamydia, c. pecorum and c. pneumoniae. while it is known that significant genetic diversity occurs in the c. pecorum strains infecting koalas, very little is known about the c. pneumoniae strains that infect this host. in the current study, 10 isolates of koala c. pneumoniae were analysed at four gene loci and found to be different to both the human and horse c. pneumoniae strains at all loci (biovar differences ranging from 0.3% at groesl up to 9.0% at ... | 1999 | 10188275 |
| detection of chlamydia pneumoniae dna in atheromatous tissues by polymerase chain reaction. | chlamydia pneumoniae is an important human respiratory pathogen. recently, seroepidemiological data and the demonstration of chlamydial dna or antigen within parts of atherosclerotic lesions have suggested a causal association between chlamydial infections and atherosclerosis. as the results obtained by different groups show considerable variations, we provide further data based on a highly specific and sensitive nested pcr method. positivity was confirmed by nonradioactive hybridization with a ... | 1999 | 10192148 |
| comparative genomes of chlamydia pneumoniae and c. trachomatis. | chlamydia are obligate intracellular eubacteria that are phylogenetically separated from other bacterial divisions. c. trachomatis and c. pneumoniae are both pathogens of humans but differ in their tissue tropism and spectrum of diseases. c. pneumoniae is a newly recognized species of chlamydia that is a natural pathogen of humans, and causes pneumonia and bronchitis. in the united states, approximately 10% of pneumonia cases and 5% of bronchitis cases are attributed to c. pneumoniae infection. ... | 1999 | 10192388 |
| alzheimer's disease: a basis in bacteria? | 1999 | 10068288 | |
| persistent chlamydial envelope antigens in antibiotic-exposed infected cells trigger neutrophil chemotaxis. | an in vitro coculture model system was used to explore conditions that trigger neutrophil chemotaxis to chlamydia trachomatis infected human epithelial cells (hec-1b). polarized hec-1b monolayers growing on extracellular matrix (ecm) were infected with c. trachomatis serovar e. by 36 h, coincident with the secretion of chlamydial lipopolysaccharide and major outer membrane protein to the surfaces of infected cells, human polymorphonuclear neutrophils (pmnl) loaded with azithromycin migrated thro ... | 1999 | 10068592 |
| lack of association between prior infection with chlamydia pneumoniae and acute or chronic coronary artery disease. | higher than normal serologic titers and the detection of bacteria within atheroma have suggested an association between chlamydia pneumoniae (c. pneumoniae) infection and coronary heart disease (chd), but the relationship has not been well established. | 1999 | 10068844 |
| c-reactive protein and coronary artery disease: additional evidence of the implication of an inflammatory process in acute coronary syndromes. | inflammation might promote the development of atherosclerosis, and high levels of c-reactive protein (crp) and fibrinogen are associated with an increased risk of acute coronary events. | 1999 | 9924170 |
| the atherogenic effects of chlamydia are dependent on serum cholesterol and specific to chlamydia pneumoniae. | epidemiological investigations have linked chlamydia pneumoniae infection to atherosclerosis. it is not clear, however, whether c. pneumoniae infection plays a causal role in the development of atherosclerosis. mice with low-density lipoprotein receptor deficiency were induced to develop atherosclerotic lesions in aorta with a cholesterol-enriched diet that increased serum cholesterol by two- to threefold. using this mouse model, we found that the chlamydial infection alone with either the c. pn ... | 1999 | 10074493 |
| coronary angioplasty induces rise in chlamydia pneumoniae-specific antibodies. | chlamydia pneumoniae is frequently found in atherosclerotic lesions, and high titers of specific antibodies are associated with increased risk for acute myocardial infarction. however, a causative relation has not been established yet. we performed a prospective study of 93 patients undergoing percutaneous transluminal coronary angioplasty (ptca) to investigate whether angioplasty influences chlamydia-specific antibody titers and whether there is an association with restenosis. blood samples wer ... | 1999 | 10074519 |
| molecular evidence for the existence of additional members of the order chlamydiales. | respiratory tract infections in man may be caused by several members of the genus chlamydia and also by two chlamydia-like strains, 'simkania negevensis' (z-agent) and 'parachlamydia acanthamoebae' (bng). to facilitate diagnostic procedures a pcr assay able to detect all known chlamydiaceae sequences in one reaction was developed. for this purpose, primers were selected to amplify a fragment of the 16s rrna gene. characterization of the amplified fragments was done by hybridization with specific ... | 1999 | 10075423 |
| [multicenter screening of chlamydia pneumoniae pneumonia by elisa method]. | we prospectively investigated the etiology of community-acquired pneumonia among adult patients admitted to three general hospitals over one year. antibody titers to chlamydia pneumoniae were also measured by elisa method to investigate the incidence and clinical pictures of c. pneumoniae pneumonia in japan. two hundred and fourteen patients were enrolled in the study. seventeen patients (7.9%) satisfied the criteria for diagnosis of acute infection due to c. pneumoniae by elisa method. c. pneum ... | 1999 | 10077904 |
| infections and immunizations of children with sickle cell disease. | children with scd are prone to invasive infections caused by s. pneumoniae and h. influenzae. osteomyelitis is caused most often by salmonella species and less often by s. aureus. the chest syndrome and its associated microvascular disease carry a risk of prolonged and severe infections for mycoplasma, chlamydia, and probably other lower respiratory pathogens, particularly in the group of children with scd prone to pain or microvascular sequestration, such as those with sc hemoglobinopathy. desp ... | 1999 | 10079855 |
| [infection and sickle cell anemia]. | sickle cell disease is associated with frequent and often severe infections as a result of immune function impairment and functional asplenia. also, infection can trigger a vasoocclusive crisis. pneumococcal bacteremia and meningitis are so severe as to warrant prophylactic penicillin therapy, which has provided a dramatic decrease in early mortality. bacterial pneumonia is common in patients younger than four years, with most cases being due to s. pneumoniae, haemophilus influenzae, mycoplasma ... | 1999 | 10081775 |
| intravenous azithromycin. | to review the pharmacology, microbiology, chemistry, pharmacokinetics, efficacy, safety, tolerability, dosage, administration, and economic issues of intravenous azithromycin. | 1999 | 10084418 |
| treatment of community-acquired pneumonia--idsa guidelines. infectious diseases society of america. | the infectious diseases society of america (idsa) has published guidelines for the treatment of community-acquired pneumonia (cap). although streptococcus pneumoniae remains the most common etiologic agent, chlamydia pneumoniae and legionella pneumophila are also important causes. for all suspected cap patients, particularly those requiring hospitalization, chest radiographs are strongly recommended to confirm the diagnosis. the idsa guidelines, in contrast to those published by the american tho ... | 1999 | 10084453 |
| [endothelial dysfunction--assessment of current status and approaches to therapy]. | the vascular endothelium is the inner lining of all blood vessels and serves as an important autocrine and paracrine organ, that regulates vascular wall functions. because of its strategic location between the circulating blood and the vascular wall, the endothelium interacts with cellular and neurohumoral mediators, thus controlling vascular contractile state and cellular composition. the vascular endothelium maintains vascular homeostasis by modulating blood vessel tone, by regulating local ce ... | 1999 | 10093015 |
| the role of viral and atypical bacterial pathogens in asthma pathogenesis. | the recent development of pcr for the diagnosis of respiratory viral infections has permitted studies revealing the importance of virus infections in acute exacerbations of asthma. several studies implicate rhinovirus as the major virus type in mild and severe wheezing illness in children of all age groups, but particularly over 1 year of age. rhinoviruses have been shown to replicate in the lower airway, suggesting that virus induced asthma exacerbations result from direct inoculation, spread o ... | 1999 | 10093125 |
| [study on the relationship between chlamydia infection and otitis media with effusion]. | to evaluate the relationship between chlamydia infection and otitis media with effusion and to establish a method for detection of chlamydia antibodies in local fluids. | 1999 | 12764856 |
| [relation between chlamydia pneumoniae infection and acute attack of asthma]. | 1999 | 11938796 | |
| [et tu chlamydia! a heart rending story]. | 1999 | 11419047 | |
| [chlamydiaceae and cancer]. | 1999 | 11830871 | |
| the role of infection in atherosclerosis and coronary artery disease: a new therapeutic target. | there is growing evidence that inflammatory processes may be involved in the development of atherosclerosis and its complications. viral and bacterial pathogens have been implicated as possible causative factors in the pathogenesis of coronary artery disease (cad) and restenosis after angioplasty. antibiotic trials are now in progress to examine whether treatment of infection can prevent the complications of cad. atherosclerosis, the primary pathologic process in coronary artery disease (cad), c ... | 1999 | 11720630 |
| [study on combined detection of m. genitalium, m. pneumoniae and c. pneumonia by nested polymerase chain reaction in respiratory tract infections in pediatric patients]. | to study the respiratory tract infections by mg, m. genitalium (mpn), cpn, and co-infections by these agents in pediatric patients. | 1999 | 11775915 |
| chlamydia pneumoniae and atherosclerosis. | chlamydia pneumoniae is the third species of the genus chlamydia and has been known to cause respiratory tract infections. since the association between the seropositivity of c. pneumoniae and ischemic heart diseases was reported in 1988, the association between c. pneumoniae and atherosclerosis has been noteworthy. positive findings of the association between c. pneumoniae and atherosclerosis have been reported as the result of seroepidemiological surveys, histological studies to detect c. pneu ... | 1999 | 10738358 |
| characterization and intracellular trafficking pattern of vacuoles containing chlamydia pneumoniae in human epithelial cells. | chlamydiae are obligate intracellular pathogens that reside within a membrane-bound vacuole throughout their developmental cycle. in this study, the intraphagosomal ph of chlamydia pneumoniae (cpn) was qualitatively assessed, and the intracellular fate of the pathogen-containing vacuole and its interaction with endocytic organelles in human epithelial cells were analysed using conventional immunofluorescence and confocal microscopy. the ph-sensitive probes acridine orange (ao), lysotracker (lyt) ... | 1999 | 11207556 |
| chlamydia species and mycoplasma pneumoniae. | chlamydia psittaci, chlamydia pneumoniae, and mycoplasma pneumoniae are a group of respiratory pathogens that have similar pulmonary and extrapulmonary manifestations. recent studies suggest that c. pneumoniae and m. pneumoniae may play a role in the pathogenesis of asthma, but further studies are needed to delineate the importance of these organisms in this disease. the diagnosis of c. pneumoniae infection is hindered by the lack of a gold standard: asymptomatic carriage of c. pneumoniae lowers ... | 1999 | 11095770 |
| chlamydia pneumoniae, the heart, and coronary artery disease: is there a cause and effect relationship? | the possibility that infection with chlamydia pneumoniae may somehow contribute to the pathogenesis of atherosclerosis continues to be explored by researchers worldwide. a direct cause-and-effect relationship between the bacterium and subsequent development of atherosclerosis has yet to be proved. however, compelling indirect evidence continues to mount in favor of this association. in this article the most recent information on this topic is reviewed. seroepidemiologic and histopathologic evide ... | 1999 | 11095780 |
| infectious agents in coronary atherosclerosis. | 1999 | 10887367 | |
| inflammation and immune response in atherosclerosis. | atherosclerosis is an inflammatory disease with a significant autoimmune component. studies using transgenic murine models have clarified that recruitment of mononuclear leukocytes through vascular leukocyte-adhesion molecules and chemokines, differentiation of monocytes to macrophages, and endocytosis through scavenger receptors all are of decisive importance for atherosclerosis in hypercholesterolemic mice. t and b cells modulate disease progression and lesion development is reduced in mice la ... | 1999 | 11122704 |
| simplified preparation of human arterial sections for pcr analysis of chlamydia pneumoniae and human dna. | to investigate multiple techniques for the preparation of solid tissue for polymerase chain reaction (pcr) analysis, and to identify the most simple techniques for routine use in the laboratory. | 1999 | 10748879 |
| chlamydia preumoniae in ischemic heart disease. | previous work has suggested an association between chlamydia pneumoniae infection and coronary artery disease. the infection was demonstrated by titers of antibodies--enzyme-linked immunosorbent assay or immunofluorescence, and polymerase chain reaction--and by the findings of c. pneumoniae in the atherosclerotic plaque. | 1999 | 10731348 |
| [infection as a likely risk factor for ischemic stroke]. | this review presents recent informations concerning the role of viral and bacterial (especially helicobacter pylori and chlamydia pneumoniae) infections in the development of ischaemic stroke. among possible pathogenic pathways that link infections and stroke, the special attention is paid to the coagulation abnormalities and immunological reactions. | 1999 | 10737040 |
| pneumonia due to unusual organisms in children. | generally antimicrobials for treatment of pneumonia are chosen to target the usual bacterial etiological agents. such regimens are unable to cure patients of pneumonia caused by 'unusual organisms' mycoplasma, chlamydia, pneumocystis carinii and legionella pneumophilus). thus, there is a need to anticipate their presence in appropriate cases and to plan the initial antimicrobial therapy accordingly. studies in europe as well as india have shown that such infections form a fairly substantial perc ... | 1999 | 10798161 |
| [chlamydia pneumoniae: an etiologic of coronary heart disease?]. | the hypothesis put forward in 1988 that chlamydia pneumoniae is the aetiological agent in coronary disease and myocardial infraction has aroused an interest in these bacteria. the epidemiology of ch. pneumoniae infections and researches on the role of it in the development of coronary artery lesions are reviewed, including animal models of this infection which could provide additional on the mechanism of atherosclerosis development. | 1999 | 10800561 |
| risk factors for coronary heart disease and persistent infection with chlamydia pneumoniae or cytomegalovirus: a population-based study. | a large number of epidemiological and pathological studies have reported on associations between coronary heart disease and persistent infection with chlamydia pneumoniae or cytomegalovirus, but relatively few have reported on possible relations between these infections and vascular risk factors. | 1999 | 10817084 |
| atherosclerosis and infection due to chlamydia pneumoniae or cytomegalovirus: weighing the evidence. | a link between infectious agents and atherosclerosis has been postulated for decades. this review describes the epidemiological and biological evidence linking cytomegalovirus and chlamydia pneumoniae to atherosclerotic disease. case-control studies and histologic evidence from atheromatous specimens support an association between atherosclerosis and infection with these two microorganisms, and small interventional trials appear to confirm the link with c. pneumoniae, but these findings require ... | 1999 | 10825031 |
| atherosclerosis: an infectious disease? | traditional risk factors do not fully account for atherogenesis. there is increasing evidence that infectious pathogens, such as helicobacter pylori, cytomegalovirus, and chlamydia pneumoniae, may promote the atherosclerotic cascade. proposed mechanisms include macrophage transformation, endothelial injury, chronic inflammation, and thrombosis. specific antibiotic therapy may affect outcome. | 1999 | 10901762 |
| [is chlamydia pneumoniae infection the risk factor of unstable angina pectoris?]. | 1999 | 10949891 | |
| the potential etiologic role of chlamydia pneumoniae in atherosclerosis. proceedings of a meeting. seattle, washington, usa. 22-25 september 1999. | 2000 | 10950654 | |
| comparative analyses of secondary gene products of 3-deoxy-d-manno-oct-2-ulosonic acid transferases from chlamydiaceae in escherichia coli k-12. | the waaa gene encoding the essential, lipopolysaccharide (lps)-specific 3-deoxy-dmanno-oct-2-ulosonic acid (kdo) transferase was inactivated in the chromosome of a heptosyltransferase i and ii deficient escherichia coli k-12 strain by insertion of gene expression cassettes encoding the waaa genes of chlamydia trachomatis, chlamydophila pneumoniae or chlamydophila psittaci. the three chlamydial kdo transferases were able to complement the knockout mutation without changing the growth or multiplic ... | 2000 | 10951204 |
| infections, immunity, and atherosclerosis: associations of antibodies to chlamydia pneumoniae, helicobacter pylori, and cytomegalovirus with immune reactions to heat-shock protein 60 and carotid or femoral atherosclerosis. | atherogenesis involves inflammatory processes in which infections are incriminated as possible contributors. | 2000 | 10952949 |
| weighing the evidence for infection as a risk factor for coronary heart disease. | there has been considerable attention in recent years to the intriguing hypothesis that coronary heart disease and other atherosclerotic diseases may be caused by infection with pathogens such as chlamydia pneumoniae, helicobacter pylori, and cytomegalovirus. supporting this hypothesis are studies that localize bacterial antigens to atherosclerotic plaques and that draw associations of systemic inflammation and chronic infections with coronary disease. although there are several examples of posi ... | 2000 | 10953260 |
| [validation of the use of an elisa test in the detection of chlamydia pneumoniae antibodies]. | 2000 | 10953617 | |
| effects of total pathogen burden on coronary artery disease risk and c-reactive protein levels. | infection and inflammation have been suggested to play roles in coronary artery disease (cad). we hypothesized that: (1) cad risk is associated with the aggregate number of pathogens (pathogen burden), and (2) increased pathogen burden is associated with elevated levels of c-reactive protein (crp), a marker of inflammation. we evaluated 233 patients for cad. blood samples from each patient were tested for immunoglobulin-g (igg) antibodies to cytomegalovirus (cmv), chlamydia pneumoniae, hepatitis ... | 2000 | 10955367 |
| serologic and histopathologic study of chlamydia pneumoniae infection in atherosclerosis: a possible pathogenetic mechanism of atherosclerosis induced by chlamydia pneumoniae. | chronic infection and inflammation have recently been implicated as important etiologic agents for atherosclerosis in general and, in particular, ischemic heart disease. several agents have been suggested as possible candidates for the chronic inflammation including cytomegalovirus, helicobacter pylori and chlamydia pneumoniae. we hypothesized that a vascular infection with c. pneumoniae may induce a chronic inflammatory reaction in the host vascular tissue and activated inflammatory cells may e ... | 2000 | 10957885 |
| decontamination of a mycoplasma-infected chlamydia pneumoniae strain by pulmonary passage in scid mice. | we describe a procedure to eliminate contaminating mycoplasma from chlamydia pneumoniae (c. pneumoniae) cultures by pulmonary passage in severe combined immunodeficiency mice (scid). four weeks after experimental infection only c. pneumoniae could be cultured from the lungs of the infected animals while mycoplasma could not be detected any longer, as shown by pcr, culture and transmission electron microscopy (tem). | 2000 | 10959732 |
| endothelial dysfunction after repeated chlamydia pneumoniae infection in apolipoprotein e-knockout mice. | arterial relaxation is largely regulated by endothelial nitric oxide (no). its diminished activity has been associated with incipient atherosclerosis. we investigated the endothelium-dependent relaxation of aorta in apolipoprotein e-knockout (apoe-ko) mice exposed to single or repeated chlamydia pneumoniae inoculation. | 2000 | 10961970 |
| [acute coronary syndrome associated with chlamydia pneumoniae pneumonia in two cases]. | epidemiological and clinical studies attribute to chlamydia pneumoniae infections a pathogenetic role in atherosclerotic vascular lesions. we report two patients in whom this infection was followed by acute coronary events. a 51 years old male presented with a right lower lobe pneumonia and a positive immunofluorescence serology for chlamydia pneumoniae, with a igm titer of 1/64. on the second day of evolution, he experienced an acute myocardial infarction. a coronary arteriography demonstrated ... | 2000 | 10962889 |
| participation of chlamydia pneumoniae in an epidemic of respiratory infections in slovakia. | in human sera collected in three regions of slovakia during an epidemic of respiratory infections, both genus-specific chlamydial and species-specific anti-chlamydia pneumoniae antibodies, as detected by enzyme-linked immunosorbent assay and microimmunofluorescence test, respectively, were found. based on seroconversion or significant rise of antibody titers and detection of antibodies of igm class, an acute c. pneumoniae infection was indicated in 21 of 298 (7.0%) patients tested. the results o ... | 2000 | 10965442 |
| chlamydia pneumoniae-associated adem. | inflammatory demyelinating diseases are a common cause of neurologic disability in young adults, and usually the cause is unknown. we describe a case of acute disseminated encephalomyelitis (adem) associated with chlamydia pneumoniae infection. an 18-year-old previously healthy women, with a one-week history of coryzal illness, was admitted because of progressive headache, dizziness, and a left-sided hemiparesis. mr imaging of the brain and brainstem showed typical signs of adem. the diagnosis w ... | 2000 | 10971604 |
| detection of mycoplasma pneumoniae and chlamydia pneumoniae in ruptured atherosclerotic plaques. | this paper reports what is apparently the first observation of mycoplasma pneumoniae in association with chlamydia pneumoniae in thrombosed ruptured atheromas. we performed electron microscopy and in situ hybridization in specimens from three patients who died of acute myocardial infarction. these patients had typical symptoms of acute ischemic syndrome. mycoplasmas were present mainly in the lipid core of the ruptured thrombosed plaque. vulnerable atheromas are rich in cholesterol and may favor ... | 2000 | 10973132 |
| prevalence of chlamydia pneumoniae and mycoplasma pneumoniae immunoglobulin g and a antibodies in a healthy finnish population as analyzed by quantitative enzyme immunoassays. | chlamydia pneumoniae and mycoplasma pneumoniae immunoglobulin g (igg) and iga antibody seroprevalence rates and antibody levels related to age and gender were studied. the samples (n = 742) were collected during a nonepidemic period and analyzed by quantitative enzyme immunoassays (eias). seroprevalence to c. pneumoniae was found to increase sharply in young children, and in the 15- to 19-year-old group it reached levels as high as 70 and 60% for igg and iga, respectively. after adolescence, ser ... | 2000 | 10973446 |
| comparison of five serologic tests for diagnosis of acute infections by chlamydia pneumoniae. | serology is often used to diagnose acute infections by chlamydia pneumoniae. in this study paired sera from patients with acute respiratory tract infection during an epidemic of c. pneumoniae infections were examined by five different antibody tests. these tests were the complement fixation (cf) test, the microimmunofluorescence (mif) test, a recombinant enzyme immunoassay (reia) (medac) based on a recombinant lipopolysaccharide of chlamydia and measuring antibodies to a common chlamydial antige ... | 2000 | 10973447 |
| evidence for antigen-driven t-cell response in unstable angina. | activation of t cells and macrophages has been associated with unstable angina (ua), but whether this reflects specific immune responses remains unclear. | 2000 | 10973839 |
| nucleic acid sequence based amplification (nasba) of chlamydia pneumoniae major outer membrane protein (ompa) mrna with bioluminescent detection. | chlamydia pneumoniae has been associated with chronic conditions such as atherosclerosis and coronary heart disease but the precise role of this intracellular bacteria in the pathogenesis of these diseases is not well defined. several techniques have been developed for detection of c. pneumoniae in atheromatous lesions, however it remains unclear whether persistent forms of the organism and/or actively replicating bacteria contribute to associated pathology. the aim of this study was to utilize ... | 2000 | 10974144 |
| helicobacter pylori is an aetiological factor for ischaemic heart disease: the case against. | helicobacter pylori is one of four organisms often investigated for ari association with ischaemic heart disease. the four, including chlamydia pneumoniae, cytomegalovirus and herpes virus, cause low-grade, life-long infections that can produce a persistent inflammation, the kind that leads to heart disease. several studies suggest an association, but others suggest none. patients with poor access to medical care are more likely to become infected and also more likely to suffer from coronary art ... | 2000 | 10975758 |
| is chlamydia pneumoniae present in the central nervous system of multiple sclerosis patients? | 2000 | 10976651 | |
| lack of chlamydia infection of the central nervous system in multiple sclerosis. | 2000 | 10976652 | |
| lack of detectable chlamydia pneumoniae in brain lesions of patients with multiple sclerosis. | 2000 | 10976653 | |
| are morphological or functional changes in the carotid artery wall associated with chlamydia pneumoniae, helicobacter pylori, cytomegalovirus, or herpes simplex virus infection? | chronic infection with chlamydia pneumoniae, helicobacter pylori, cytomegalovirus (cmv), and herpes simplex virus (hsv) has been implicated in the pathogenesis of atherosclerosis. the carotid intima-media thickness (imt) can be taken to indicate early atherosclerosis, the presence of a carotid stenosis is a marker of a manifest carotid atherosclerosis, and an increase in arterial stiffness is used as marker of structural and functional changes in an atherosclerotic vessel wall. | 2000 | 10978041 |
| commentary: adjustment for potential confounders may have been taken too far. | 2000 | 10979671 | |
| animal models of infection-mediated vasculitis: implications for human disease. | the human vasculitides including takayasu's arteritis are idiopathic syndromes for which both autoimmune and infectious etiologies have been proposed. although proof of a correlation between infection and human vasculitis would aid in patient management, it is difficult to confirm causality. to study infection-mediated vascular disease, different animal models have been developed. infections with the bacteria c. pneumoniae, an rna virus, and herpesviruses all cause vascular pathology and will be ... | 2000 | 10980335 |
| [the relationship between immunological parameters with etiopathogenesis and clinical course of stroke]. | we observed a lot of immune system disorders significantly influencing the development and clinical course of stroke. depression of cell-mediated immune reactivity was observed in the early stage of stroke. it was manifested by the decrease of the number of t lymphocytes, depression in lymphocyte blastogenesis, diminished production of the migration inhibition factor and reduced delayed-type skin reactivity. observed depression was probably caused by severe metabolic and endocrinological disorde ... | 2000 | 10983297 |
| [the role of chlamydia pneumoniae in atherogenesis]. | 2000 | 10983358 | |
| importance of atypical pathogens of community-acquired pneumonia. | the atypical clinical presentation of patients with community-acquired pneumonia (cap) was first recognized and reported by astute clinicians 50 years ago. the cause of pneumonia in this group eventually was shown to be mycoplasma pneumoniae. more recently, chlamydia pneumoniae also has been recognized as a cause of cap. legionella has been lumped together with m. pneumoniae and c. pneumoniae because of its antimicrobial susceptibility pattern. this group of organisms is susceptible to the macro ... | 2000 | 10984326 |
| chlamydia pneumoniae dna in non-coronary atherosclerotic plaques and circulating leukocytes. | earlier studies have associated atherosclerosis with chlamydia pneumoniae infection. c. pneumoniae may circulate via monocytes and migrate into plaques by leukocyte infiltration; however, detection is difficult. we developed a novel polymerase chain reaction (pcr) method to test the hypothesis that c. pneumoniae dna in circulating leukocytes is correlated with c. pneumoniae dna in plaque material and that c. pneumoniae copy number is associated with disease severity. we obtained plaques from 130 ... | 2000 | 10985497 |
| comparison of anesthetics for inoculation of mice with chlamydia pneumoniae. | 2000 | 10987668 | |
| immunohistochemical staining for chlamydia pneumoniae is increased in lung tissue from subjects with chronic obstructive pulmonary disease. | the seroprevalence of chlamydia pneumoniae is increased in chronic obstructive pulmonary disease (copd), and subjects with copd are more likely to have a positive polymerase chain reaction for c. pneumoniae in their sputum. it has been suggested that c. pneumoniae may have a role in the pathogenesis of copd. we undertook immunohistochemistical staining for c. pneumoniae in archival tissue from subjects who had undergone lobectomy for bronchial carcinoma. there were 16 subjects with copd (fev(1) ... | 2000 | 10988144 |
| the role of chlamydia in the pathogenesis of pulmonary emphysema. electron microscopy and immunofluorescence reveal corresponding findings as in atherosclerosis. | chlamydia pneumoniae has been detected in atherosclerotic plaques by various means. chlamydiae are able to cause persistent infections. serologically elevated antibody titers are found in severe chronic obstructive pulmonary disease. in atherosclerosis and pulmonary emphysema, inflammatory reactions can be seen by means of light microscopy. specimens from patients with obliterative arteriosclerosis undergoing thrombendarteriectomy and with advanced emphysema undergoing lung volume reduction surg ... | 2000 | 10993281 |
| inflammation is associated with carotid atherosclerosis in dialysis patients. creed investigators. cardiovascular risk extended evaluation in dialysis patients. | to investigate the relationship between inflammatory processes and atherosclerosis in uraemic patients on chronic dialysis. | 2000 | 10994751 |
| rationalised prescribing for community acquired pneumonia: a closed loop audit. | to audit the management of community acquired pneumonia before and after the introduction of a protocol. to determine the aetiology of pneumonia using routine investigations and polymerase chain reaction (pcr). | 2000 | 10999868 |
| [chronic chlamydia pneumoniae infection in patients with asthma]. | the aim of our study was to evaluate the frequency of chlamydia pneumoniae infection (especially chronic infection) in 41 asthma patients. they have been assigned to 3 groups, according to disease severity. control group consisted of 35 age matched healthy volunteers (without cardiac and pulmonary diseases). the levels of specific igg, iga and igm in patients' serum have been estimated using indirect microimmunofluorescence. according to serologic criteria, 23(56.1%) asthma patients and 4(11.4%) ... | 2000 | 11004864 |
| [chronic chlamydia pneumonia infection in patients with chronic obstructive pulmonary disease]. | the aim of our study was to evaluate the frequency of chlamydia pneumoniae infection (especially chronic infection) in copd patients. microimmunofluorescence method has been applied chlamydia pneumoniae micro-if test (labsystems) has been used. the levels of specific igg, iga and igm have been estimated in patients' serum. according to serologic criteria, 64.1% of copd patients and 20.5% of healthy controls appeared to be chronically infected with chlamydia pneumoniae (p < 0.001). taking in acco ... | 2000 | 11004865 |
| [the role of infection in chronic obstructive pulmonary disease]. | 2000 | 11004868 | |
| combined seropositivity for h. pylori and c. pneumoniae is associated with age, obesity and social factors. | manifestations of cardiovascular disease (cvd) have been associated with chronic infection by helicobacter pylori and chlamydia pneumoniae both in cross-sectional and in prospective follow-up cohort studies. this association may be partly due to an increase in metabolic risk factors for cvd, secondary to low-grade inflammation caused by infections. | 2000 | 11006888 |
| high prevalence of seropositivity for antibodies to chlamydia-specific lipopolysaccharide in patients with acute coronary syndrome. | results of recent studies have demonstrated that there is an association between infection with chlamydia pneumoniae and coronary artery disease (cad). inflammatory response caused by chlamydial infection has been considered to contribute to the development of atherosclerosis in coronary arteries. | 2000 | 11006891 |
| the genomics gamble. | 2000 | 11017061 | |
| in vivo uptake of azithromycin in human coronary plaques. | ten patients with symptomatic coronary artery disease received oral azithromycin for 3 days and underwent directional atherectomy on the third day. azithromycin was found in all plaque samples with a median concentration of 284 ng/ml (95% confidence interval 163 to 517 ng/ml). | 2000 | 11018204 |
| inflammation, depressive symptomtology, and coronary artery disease. | many patients feel exhausted or depressed before the onset of an acute coronary event, but little is known about the origin of these feelings. we tested the hypothesis that the depressive symptomatology is associated with a reactivation of latent viruses and inflammation of a coronary vessel. | 2000 | 11020087 |
| chlamydia pneumoniae infection and pfo-associated ischemic stroke. | 2000 | 11022089 | |
| chlamydia pneumoniae induces interleukin-10 production that down-regulates major histocompatibility complex class i expression. | recently, it was demonstrated that cd8(+) t cells are important for the response against chlamydia pneumoniae. by use of the human monocytic cell line u937 and human monocytes taken from peripheral blood, we investigated the effect of infection on various molecules critical for cd8(+) t cell function. a strong secretion of interleukin (il)-10 by infected cells was observed, together with an inhibited expression of major histocompatibility complex (mhc) class i antigens, but without significant a ... | 2000 | 11023462 |
| chlamydia pneumoniae viability in atherosclerotic tissue: true or false? | 2000 | 11023490 | |
| secondary prevention antibiotic treatment trials for coronary artery disease. | 2000 | 11023925 | |
| randomized secondary prevention trial of azithromycin in patients with coronary artery disease: primary clinical results of the academic study. | chlamydia pneumoniae is associated with coronary artery disease (cad), although its causal role is uncertain. a small preliminary study reported a >50% reduction in ischemic events by azithromycin, an antibiotic effective against c pneumoniae, in seropositive cad patients. we tested this prospectively in a larger, randomized, double-blind study. | 2000 | 11023928 |
| the effect of chronic azithromycin therapy on soluble endothelium-derived adhesion molecules in patients with coronary artery disease. | in patients with coronary artery disease (cad), azithromycin therapy is associated with decreased cytokine levels and overall reduction of inflammation. chlamydia pneumoniae (c.pn) is a common pathogen that may be an important factor in the development and progression of atherosclerosis. cell-adhesion molecules have an important role in recruitment of inflammatory cells during plaque development and are expressed by endothelial cells on activation. we sought to define the effect of treatment wit ... | 2000 | 11026657 |
| [serological diagnosis and nasopharyngeal washings in pediatric infections]. | in the course of respiratory infections, the efficacy of microbiologic diagnosis has increased years after years, in term of specificity, sensitivity and rapidity. new pathogenic agents have been described such as: legionella pneumophila, chlamydia pneumoniae, hantavirus. some viruses have been well characterized as responsible for seasonal outbreaks using rapid tools for identification. needs for efficient diagnostic tools became more obvious when specific antiviral drugs appeared on the market ... | 2000 | 11028183 |
| identification and mapping of sigma-54 promoters in chlamydia trachomatis. | the first sigma(54) promoters in chlamydia trachomatis l2 were mapped upstream of hypothetical proteins ct652.1 and ct683. comparative genomics indicated that these sigma(54) promoters and potential upstream activation binding sites are conserved in orthologous c. trachomatis d, c. trachomatis mouse pneumonitis strain, and chlamydia pneumoniae (cwl029 and ar39) genes. | 2000 | 11029448 |
| frequent contamination of chlamydia trachomatis and chlamydia pneumoniae strains with mycoplasma. biological relevance and selective eradication of mycoplasma from chlamydial cultures with mupirocin. | several strains of chlamydia trachomatis (ct) and c. pneumoniae (cp) from different sources were screened for mycoplasma contamination using a sensitive nested 16s rdna polymerase chain reaction-specific for a broad range of mycoplasma species. five of nine ct and 5/16 cp isolates were contaminated by mycoplasma. mycoplasma fermentans, m. hyorhinis and m. hominis were found as contaminating agents. to our knowledge no data are available on whether coinfection of chlamydia with mycoplasma alters ... | 2000 | 11034554 |
| cytomegalovirus seropositivity and c-reactive protein have independent and combined predictive value for mortality in patients with angiographically demonstrated coronary artery disease. | the role of inflammation in coronary artery disease (cad) is being increasingly recognized. markers of inflammation (eg, c-reactive protein [crp]) and infection (eg, seropositivity to chlamydia pneumoniae, cytomegalovirus [cmv], and helicobacter pylori) have been proposed as risk factors for cad, but these associations require further evaluation. | 2000 | 11034939 |
| inhibition of chlamydia pneumoniae replication in human aortic smooth muscle cells by gamma interferon-induced indoleamine 2, 3-dioxygenase activity. | infection with chlamydia pneumoniae, a human respiratory pathogen, has been implicated as a potential risk factor in atherosclerosis, possibly because the pathogen can exist in a persistent form similar to that described for chlamydia trachomatis. the present study investigated whether gamma interferon (ifn-gamma) can induce indoleamine 2,3-dioxygenase (ido) activity in aortic smooth muscle cells, leading to a marked inhibition of c. pneumoniae growth. our data indicate a stimulation of ido mrna ... | 2000 | 11035763 |