Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| epstein-barr virus infection and expression in oral lesions. | the prevalence of epstein-barr virus (ebv) and the recently discovered kaposi's sarcoma associated herpes virus, human herpesvirus 8 (kshv or hhv8), was determined within oral lesions common to hiv infection including ohl, pseudoohl (phl), oral lymphoma, oral aphthous ulcers, and an oral kaposi's sarcoma. | 1997 | 9456682 |
| gene therapy strategies for aids-related malignancies. | aids-related malignancies (arm) include aids-defining cancers such as kaposi's sarcoma, non-hodgkin's lymphoma and cervical carcinoma. in addition, certain other malignancies are also increased with human immunodeficiency virus (hiv) infection. new antiretroviral agents and better prophylaxis and treatment of hiv-related opportunistic infections are prolonging the lives of hiv-infected individuals. there will thus likely be a continued rise in the incidence and prevalence of arm in the long term ... | 1997 | 9472551 |
| kshv orf k9 (virf) is an oncogene which inhibits the interferon signaling pathway. | kaposi's sarcoma-associated herpesvirus (kshv) is a gammaherpesvirus linked to the development of kaposi's sarcoma and a rare b cell lymphoma, primary effusion lymphoma. the kshv gene orf k9 encodes virf which is a protein with low but significant homology to members of the interferon (ifn) regulatory factor (irf) family responsible for regulating intracellular interferon signal transduction (moore ps, boshoff c, weiss ra and chang y. (1996). science, 274, 1739-1744). virf inhibits ifn-beta sign ... | 1997 | 9365244 |
| risk factors for kaposi's sarcoma in hiv-positive subjects in uganda. | kaposi's sarcoma (ks) is associated epidemiologically with hiv infection and with human herpesvirus 8 (hhv-8 or kshv). both ks and hiv infection are common in uganda. we conducted a case-control study of 458 hiv-seropositive. ugandan adults with ks and 568 hiv-seropositive subjects without ks to examine risk factors for hiv-associated ks. | 1997 | 9365767 |
| complete remission of aids-related kaposi's sarcoma associated with undetectable human herpesvirus-8 sequences during anti-hiv protease therapy. | 1997 | 9365774 | |
| detection rate and intratumoral virus load of human herpesvirus-8 in immunodeficiency-related b-cell lymphoid malignancies. | human herpesvirus-8 (hhv-8), associated with kaposi's sarcoma, primary effusion lymphoma, and castleman's disease, has been found in circulating b-cells and might have a causative role in b-cell malignancies associated with immunodeficiency syndromes. we determined the rate of detection and intratumoral virus load of hhv-8 by means of a semiquantitative approach in post-transplant lymphoproliferative diseases (ptlds), aids-related non-hodgkin's lymphomas (nhls), including both burkitt's lymphoma ... | 1997 | 9365896 |
| identification of the gene encoding the major latency-associated nuclear antigen of the kaposi's sarcoma-associated herpesvirus. | over 85% of patients with kaposi's sarcoma (ks) are seropositive for antibodies to the latency-associated nuclear antigen (lana) expressed in b cell lines infected with kaposi's sarcoma-associated herpesvirus (kshv). the presence of antibodies to lana strongly correlates with the risk of developing the disease. however, the identity of the protein(s) comprising lana and the corresponding gene(s) has remained unclear. to identify potential latent gene candidates for lana, we probed total rna extr ... | 1997 | 9366576 |
| non-hodgkin lymphoma and kaposi sarcoma in an eyelid of a patient with acquired immunodeficiency syndrome. multiple viruses in pathogenesis. | a 36-year-old patient with acquired immunodeficiency syndrome sought care because of an upper eyelid lesion that dramatically increased in size. the histopathologic examination revealed a high-grade diffuse large cell non-hodgkin lymphoma in continuity with a kaposi sarcoma. in situ hybridization revealed epstein-barr virus in the large cell lymphoma and kaposi sarcoma-associated herpesvirus in the kaposi sarcoma lesion. this collision tumor is an unusual presentation of 2 malignant neoplasms in ... | 1997 | 9366682 |
| identification of hhv-8 dna in the skin lesions of kaposi's sarcoma in an immunosuppressed patient with bullous pemphigoid. | kaposi's sarcoma rarely occurs as an opportunistic tumor in iatrogenically immunosuppressed patients. we describe the clinical presentation, treatment of kaposi's sarcoma skin lesions in an immunosuppressed patient with bullous pemphigoid. using the polymerase chain reaction, hhv-8 dna was detected in two separate kaposi's sarcoma lesions but not in control tissues. the amplified dna fragments derived from our patient's kaposi's sarcoma skin lesions contained unique point mutations that distingu ... | 1997 | 9366849 |
| herpes viral cyclin/cdk6 complexes evade inhibition by cdk inhibitor proteins. | the passage of mammalian cells through the restriction point into the s phase of the cell cycle is regulated by the activities of cdk4 and cdk6 complexed with the d-type cyclins and by cyclin e/cdk2. the activities of these holoenzymes are constrained by cdk inhibitory proteins. the importance of the restriction point is illustrated by its deregulation in many tumour cells and upon infection with dna tumour viruses. here we describe the properties of cyclins encoded by two herpesviruses, herpesv ... | 1997 | 9367157 |
| a herpesvirus of rhesus monkeys related to the human kaposi's sarcoma-associated herpesvirus. | a herpesvirus that is related to but distinct from the kaposi's sarcoma-associated herpesvirus (kshv, or human herpesvirus 8) was isolated from rhesus monkeys. the sequence of 10.6 kbp from virion dna revealed the presence of an interleukin-6 homolog similar to what is present in kshv and a closer relatedness of the dna polymerase and glycoprotein b reading frames to those of kshv than to those of any other herpesvirus. this rhesus monkey herpesvirus replicated lytically and to high titers in cu ... | 1997 | 9371642 |
| localization of kaposi's sarcoma-associated herpesvirus in bone marrow biopsy samples from patients with multiple myeloma. | we have recently demonstrated the presence of kaposi's sarcoma-associated herpesvirus (kshv) in cultured bone marrow (bm) stromal dendritic cells from all patients with myeloma studied. to show that these findings were not an artifact of tissue culture, we performed in situ hybridization (ish) and polymerase chain reaction (pcr) to detect kshv in bm core biopsies. using ish to open reading frame-72 (orf 72), we localized kshv to bm dendritic cells in 17 of 20 patients with myeloma, 2 patients wi ... | 1997 | 9373238 |
| the kshv/hhv8-infected bcbl-1 lymphoma line causes tumors in scid mice but fails to transmit virus to a human peripheral blood mononuclear cell graft. | the body-cavity-based lymphoma cell line bcbl-1, which is infected with kaposi's sarcoma-associated herpesvirus/human herpesvirus 8, was injected alone or with human peripheral blood mononuclear cells into scid mice. immunoblastic lymphomas developed at or near the site of injection. the lymphomas appeared to derive exclusively from the injected bcbl-1 cells and not from the injected human pbmc. the tumors elicited a marked murine angiogenic response, but known angiogenic cytokines were not dete ... | 1997 | 9375005 |
| human herpesvirus 8 dna sequences in blistering skin from patients with pemphigus. | human herpesvirus 8 (hhv-8) has been detected in kaposi sarcoma (ks) and other lesions in patients both seropositive and seronegative for the human immunodeficiency virus (hiv). kaposi sarcoma has been reported to develop in a disproportionate number of patients with pemphigus. since hhv-8 is so strongly associated with ks, we wondered whether hhv-8 is present in pemphigus lesions from patients without ks or hiv infection. pemphigus lesions and skin from healthy individuals were coded in a blind ... | 1997 | 9382563 |
| [sequences of human herpes virus type 8 and epstein-barr virus in aids-related primary central nervous system non-hodgkin's lymphoma]. | presence of human herpes virus type 8 (hhv8), detected by nested pcr, and expression of epstein-barr virus (ebv), as assessed by immunochemistry and in situ hybridization, were evaluated in 20 primary non-hodgkin immunoblastic lymphomas (nhl) of the central nervous system (cns) from patients who died from aids, and in 10 samples of cerebral tissues from patients who died from aids, without cerebral lymphoma or kaposi's sarcoma, as controls. six lymphomas (30%) contained hhv8 sequences, and 19 (9 ... | 1997 | 9382608 |
| geography of aids-associated kaposi's sarcoma in europe. | classical kaposi's sarcoma (ks) is about four times more common in southern europeans than in northern europeans. | 1997 | 9386809 |
| establishment of hhv-8-positive and hhv-8-negative lymphoma cell lines from primary lymphomatous effusions. | primary lymphomatous effusions are represented by cases of non-hodgkin's lymphoma (nhl) which grow in liquid phase in the serous body cavities in the absence of solid tumour masses. based on morphologic, immunophenotypic, virologic and genotypic features, primary lymphomatous effusions are distinguished into body cavity-based lymphoma (bcbl), burkitt's lymphoma (bl) and immunoblastic large-cell lymphoma. the histogenesis and pathogenesis of primary lymphomatous effusions are virtually unclarifie ... | 1997 | 9389573 |
| association of kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma with expression of the cd138/syndecan-1 antigen. | primary effusion lymphoma (pel) represents a novel b-cell non-hodgkin's lymphoma (nhl) type associated with kaposi's sarcoma-associated herpesvirus infection and typically growing as lymphomatous effusions in the body cavities. the precise b-cell subset from which pel originates as well as the biologic mechanisms responsible for its peculiar growth pattern are unclear. in this study, we have analyzed pel for the expression status of cd138/syndecan-1, a molecule selectively associated with late s ... | 1997 | 9389706 |
| phase i study of human chorionic gonadotropin given subcutaneously to patients with acquired immunodeficiency syndrome-related mucocutaneous kaposi's sarcoma. | in vitro and in vivo clinical studies have shown that certain preparations of human chorionic gonadotropin have antitumor activity against kaposi's sarcoma, the most common tumor in patients infected with human immunodeficiency virus type 1 (hiv-1). | 1997 | 9392621 |
| detection of bcl-6 rearrangements and p53 mutations in malt-lymphomas. | twenty-seven lymphomas of mucosa-associated lymphoid tissue (malt) derived from distinct anatomical sites were tested for the presence of genetic lesions commonly involved in b-cell lymphomagenesis, including activation of proto-oncogenes (bcl-1, bcl-2, bcl-6, and c-myc), disruption of tumor suppressor loci (p53, 6q), and infection by viruses [epstein-barr virus (ebv), and kaposi's sarcoma-herpesvirus/human herpesvirus-8 (kshv/hhv-8)]. sixteen low-grade and 11 high-grade malt-lymphomas were incl ... | 1997 | 9395180 |
| hhv-8 (kshv) does not establish latency in prostate cancer cell lines. | hhv-8 is a new herpesvirus found in lesions of kaposi's sarcoma and some lymphoproliferative diseases. more recently, a report stated that normal prostate tissue also contains the virus. | 1997 | 9397202 |
| human herpesvirus 8 variants in sarcoid tissues. | the cause of sarcoidosis is unknown, although mycobacteria have been implicated. we examined sarcoid tissues for human herpesvirus 8 (hhv-8) in addition to mycobacterial genomic sequences. | 1997 | 9400509 |
| kaposi's sarcoma--associated herpesvirus-like dna sequences are not present in adult t-cell leukemia. | 1997 | 9401287 | |
| multiple myeloma and kaposi's sarcoma-associated herpesvirus--a paracrine model of tumorigenesis? | 1997 | 9402694 | |
| expression of a virus-derived cytokine, kshv vil-6, in hiv-seronegative castleman's disease. | castleman's disease is a rare b cell lymphoproliferative disorder related to excess interleukin-6 (il-6)-like activity. kaposi's sarcoma-associated herpesvirus (kshv or hhv8), which encodes a functional cytokine (vil-6), has been found in some patients with castleman's disease. lymph nodes from 14 hiv-seronegative castleman's disease patients were compared to hyperplastic lymph nodes from 25 hiv-seronegative patients as well as kaposi's sarcoma lesions from 48 patients for kshv infection and vil ... | 1997 | 9403701 |
| absence of human herpesvirus 8 and epstein-barr virus genome sequences in cutaneous epithelial neoplasms arising in immunosuppressed organ-transplant patients. | recent studies have implicated herpesvirus 8 and epstein-barr virus in the development of cutaneous malignancies in immunosuppressed patients. in order to examine the strength of this association, we examined 37 malignant, pre-malignant and benign cutaneous epithelial neoplasms removed from immunosuppressed organ recipients for the presence of human herpesvirus 8 and epstein-barr viral genome sequences using polymerase chain reaction (pcr) and in situ hybridization. we examined 2 actinic keratos ... | 1997 | 9404853 |
| the liver in aids. | deficits in cell-mediated immunity in aids result in a wide variety of hepatic complications, including granulomas, cytomegalovirus hepatitis, multimicrobial aids cholangiopathy, kaposi's sarcoma, and lymphoma. kupffer cells are the major hepatic target cell population for human immunodeficiency virus-1 (hiv-1), and rhesus monkeys with simian immunodeficiency virus infection have served as a model for ultrastructural analysis of viral clearance by these cells. the majority of patients with estab ... | 1997 | 9408969 |
| [kaposi sarcoma: a virus-induced tumor?]. | 1997 | 9410697 | |
| kaposi's sarcoma patients in the swiss hiv cohort study with and without detectable human herpesvirus 8 in peripheral blood mononuclear cells. | 1997 | 9412715 | |
| kaposi's sarcoma and kaposi's sarcoma associated herpesvirus (human herpesvirus 8): where are we now? | 1997 | 9414165 | |
| expression of human herpesvirus 8-encoded cyclin d in kaposi's sarcoma spindle cells. | human herpesvirus 8 (hhv-8) dna sequences have been detected in kaposi's sarcoma, in primary effusion lymphoma (an unusual high-grade non-hodgkin's lymphoma seen primarily in patients with acquired immunodeficiency syndrome [aids]), and in castleman's disease (a rare lymphoproliferative disorder); however, proof that hhv-8 is involved in the pathogenesis of these diseases remains to be established. hhv-8 contains a gene, i.e., v-cyclin d, that is a homologue of the cellular cyclin d2 gene, which ... | 1997 | 9414174 |
| raynaud's phenomenon and digital gangrene as a consequence of treatment for kaposi's sarcoma. | to analyze the clinical features and to identify factors associated with the development of raynaud's phenomenon (rp) in patients receiving chemotherapy for human immunodeficiency virus (hiv) related kaposi's sarcoma. | 1997 | 9415644 |
| kaposi's sarcoma-associated herpesvirus infection and multiple myeloma. | 1997 | 9417642 | |
| kaposi's sarcoma-associated herpesvirus infection and multiple myeloma. | 1997 | 9417643 | |
| kaposi's sarcoma-associated herpesvirus infection and multiple myeloma. | 1997 | 9417644 | |
| kaposi's sarcoma-associated herpesvirus infection and multiple myeloma. | 1997 | 9417645 | |
| kaposi's sarcoma-associated herpesvirus infection and multiple myeloma. | 1997 | 9417646 | |
| [kaposi disease]. | 1997 | 9615706 | |
| retroviruses | infections by viruses of the lentivirus genus, most notably human immunodeficiency virus type 1 (hiv-1), are characterized by remarkably complex interactions with the host and a chronic course of disease. common features of diseases caused by lentiviruses include long and variable incubation periods, persistent viral replication, neurologic manifestations, and destruction of specific hematologic or immunologic cells ... | 1997 | 21433338 |
| recent progress in the biology of multiple myeloma and future directions in the treatment. | a great amount of scientific information, accumulated over recent years on the biology of multiple myeloma (mm), has fuelled speculation about the origin of malignant plasma cells, about a purported critical role played by the bone marrow stroma, and further still, on cytokine interactions and in particular that of il-6 and its relationship with the immune system. among the growth factors secreted by stroma cells, il-6 is a potent stimulator of myeloma cells in vitro but does not induce a malign ... | 1998 | 9615247 |
| distribution of human herpesvirus 8 dna in tumorous and nontumorous tissue of patients with acquired immunodeficiency syndrome with and without kaposi's sarcoma. | human herpesvirus 8 (hhv-8) dna is present in virtually all kaposi's sarcomas (kss). conflicting results, however, exist with respect to the presence of hhv-8 in nontumorous tissue samples. to define the specificity and predictive value of hhv-8 dna detection in ks, we analyzed autopsy-derived tissue samples from patients with acquired immunodeficiency syndrome (aids) with and without ks for the presence of hhv-8 dna, using single-step and nested polymerase chain reaction. semiquantitative analy ... | 1998 | 9619592 |
| clinical and biological impact of antiretroviral therapy with protease inhibitors on hiv-related kaposi's sarcoma. | to evaluate the clinical and biological impact of protease inhibitors on hiv-associated kaposi's sarcoma. | 1998 | 9619797 |
| seroprevalence of hhv-8 antibodies in hiv-positive homosexual men without kaposi's sarcoma and their clinical follow-up. | human herpesvirus 8 (hhv-8) has been associated with kaposi's sarcoma (ks). because ks is most frequently seen in hiv-positive homosexual men, we retrospectively evaluated the seroprevalence of hhv-8 in this risk group and compared the clinical history and clinical course of the hhv-8-negative and hhv-8-positive groups. the study was performed by analyzing banked serum samples from asymptomatic hiv-positive men. hhv-8 seropositivity was determined by an indirect immunofluorescence test. a total ... | 1998 | 9620039 |
| mapping and serodiagnostic application of a dominant epitope within the human herpesvirus 8 orf 65-encoded protein. | a dominant epitope within the human herpesvirus 8 (hhv8) orf 65-encoded protein was mapped to an 8-amino-acid (aa) sequence (rkppsgkk [aa 162 to 169]) by an amino acid replacement method. using a 14-aa peptide (p4) encompassing this epitope as the antigen, we developed an enzyme immunoassay for hhv8 antibodies. the presence of p4 antibodies in a panel of 61 human serum specimens was highly correlated with biopsy-confirmed kaposi's sarcoma. the homologous epstein-barr virus peptide derived from b ... | 1998 | 9620379 |
| high human herpesvirus 8 seroprevalence in the homosexual population in switzerland. | the seroprevalence of human herpesvirus 8 (hhv-8) in the swiss population was investigated. by enzyme-linked immunosorbent assay, sera reactive to the recombinant hhv-8 antigen orf 65.2 were found in 24% of human immunodeficiency virus (hiv)-positive patients without and in 92% of hiv-positive patients with kaposi's sarcoma. surprisingly, 20% of homosexual hiv-negative men, versus only 7% of heterosexual hiv-negative individuals and 5% of blood donors, had antibodies to hhv-8. | 1998 | 9620422 |
| kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor. | interferons (ifns) are a family of multifunctional cytokines with antiviral activities. the k9 open reading frame of kaposi's sarcoma-associated herpesvirus (kshv) exhibits significant homology with cellular ifn regulatory factors (irfs). we have investigated the functional consequence of k9 expression in ifn-mediated signal transduction. expression of k9 dramatically repressed transcriptional activation induced by ifn-alpha, -beta, and -gamma. further, it induced transformation of nih 3t3 cells ... | 1998 | 9620998 |
| human immunodeficiency virus tat modulates the flk-1/kdr receptor, mitogen-activated protein kinases, and components of focal adhesion in kaposi's sarcoma cells. | kaposi's sarcoma (ks) spindle cell growth and spread have been reported to be modulated by various cytokines as well as the human immunodeficiency virus (hiv) gene product tat. recently, hiv-1 tat has been shown to act like a cytokine and bind to the flk-1/kdr receptor for the vascular endothelial growth factor a (vegf-a), which is expressed by ks cells. we have characterized signal transduction pathways stimulated by hiv-1 tat upon its binding to surface receptors on ks cells. we observed that ... | 1998 | 9621077 |
| human herpesvirus 8 in the prostate glands of men with kaposi's sarcoma. | the epidemiology of human immunodeficiency virus (hiv)-associated kaposi's sarcoma (ks) resembles that of a sexually transmitted pathogen. however, human herpesvirus 8 (hhv-8), the proposed cause of ks, is found in semen only infrequently and at low titers. to determine whether hhv-8 was present in the urogenital tract, transrectal ultrasound-guided prostate biopsies were obtained from six men with ks (five with concurrent hiv infection) and four without ks (three with concurrent hiv) and assaye ... | 1998 | 9621094 |
| cloning and functional analysis of kaposi's sarcoma-associated herpesvirus dna polymerase and its processivity factor. | kaposi's sarcoma-associated herpesvirus (kshv), or human herpesvirus 8, is a newly identified virus with tumorigenic potential. here, we cloned and expressed the dna polymerase (pol-8) of kshv and its processivity factor (pf-8). pol-8 bound specifically to pf-8 in vitro. moreover, the dna synthesis activity of pol-8 was shown in vitro to be strongly dependent on pf-8. addition of pf-8 to pol-8 allowed efficient synthesis of fully extended dna products corresponding to the full-length m13 templat ... | 1998 | 9621095 |
| identification of hhv8 in early kaposi's sarcoma: implications for kaposi's sarcoma pathogenesis. | kaposi's sarcoma is a vascular tumour of uncertain pathogenesis possibly caused by an infectious agent, identified in high risk groups. accumulating solution phase polymerase chain reaction (pcr) and seroepidemiological data suggest that a previously undescribed herpes dna virus (human herpesvirus 8 (hhv8)) is the causative agent. using a unique cohort of early kaposi's sarcoma, the precise cell type infected with hhv8 in such lesions was identified to elucidate further the role of hhv8 in the p ... | 1998 | 9624414 |
| treatment of classical kaposi's sarcoma with intralesional injections of cidofovir: report of a case. | the effect of intralesional injections of cidofovir, a nucleotide analog with potent in vitro activity against human herpesvirus 8 (hhv-8), was studied in vivo in an hiv-negative patient with classical kaposi's sarcoma (ks). after five weekly injections of the drug, no clinical, histological, immunohistological, or virological changes could be detected in comparison with saline-injected lesions. these findings suggest that, once the ks tumor has developed, active viral replication is no longer i ... | 1998 | 9624609 |
| fibronectin modulates the effects of hiv-1 tat on the growth of murine kaposi's sarcoma-like cells through the down-regulation of tyrosine phosphorylation. | hiv-1 tat plays a role in the pathogenesis of kaposi's sarcoma. we therefore investigated the effect of tat on the growth of murine kaposi's sarcoma-like spindle (ttb) cells derived from dermal lesions. we observed that tat and a peptide corresponding to the carboxyl-terminal region (tat65-80) containing an rgd sequence inhibit ttb cell proliferation only when cells are cultured on fibronectin. this inhibitory effect correlates with redistribution of the alpha(v) integrin subunit on the surface ... | 1998 | 9626063 |
| highly active antiretroviral therapy in human herpesvirus-8-related body-cavity-based lymphoma. | 1998 | 9631153 | |
| restricted expression of epstein-barr virus (ebv)-encoded, growth transformation-associated antigens in an ebv- and human herpesvirus type 8-carrying body cavity lymphoma line. | a body cavity lymphoma-derived cell line (bc1), known to carry both epstein-barr virus (ebv) and human herpes virus type 8 (hhv-8; or kaposi's sarcoma-associated herpesvirus, kshv), was analysed for the expression of ebv-encoded, growth transformation-associated antigens and cellular phenotype by immunofluorescence staining, western blotting, rt-pcr and flow cytometry. a similar phenotypic analysis was also performed on another body cavity lymphoma line, bcbl1, that is singly infected with hhv-8 ... | 1998 | 9634087 |
| hiv-1-associated kaposi's sarcoma in a predominantly black population at an inner city hospital. | kaposi's sarcoma (ks) associated with human immunodeficiency virus type 1 (hiv-1) is the most common malignancy in patients with aids. it has been most commonly reported in white homosexual men, though a few cases have been reported in blacks. | 1998 | 9634116 |
| association of kaposi's sarcoma associated herpesvirus (kshv) dna in bronchoalveolar lavage fluid of hiv infected individuals with bronchoscopically diagnosed tracheobronchial kaposi's sarcoma. | to determine the frequency of detection of kaposi's sarcoma associated herpesvirus (kshv), also known as human herpesvirus (hhv) type 8, dna in bronchoalveolar lavage (bal) fluid from hiv infected individuals with and without ks and to compare this with the detection rate in peripheral blood. also to identify whether kshv was associated with specific cell types in lavage fluid. | 1998 | 9634297 |
| detection and titration of human herpesvirus-8-specific antibodies in sera from blood donors, acquired immunodeficiency syndrome patients, and kaposi's sarcoma patients using a whole virus enzyme-linked immunosorbent assay. | a human herpesvirus-8 (hhv-8) enzyme-linked immunosorbent assay (elisa) with a whole virus lysate as antigen was developed and used to measure the seroprevalence rate and levels of igg antibodies to hhv-8 in sera/plasma of various patient groups and blood donors. the virus antigen was prepared from the ks-1 cell line, which produces lytic virus, and therefore contains a broad array of viral proteins. seroprevalence studies using this elisa showed the following: 10 of 91 blood donors (11%) had an ... | 1998 | 9639499 |
| the effectiveness of intermittent hyperbaric oxygen in relieving drug-induced hiv-associated neuropathy. | this 3-month study evaluated the effects of hyperbaric oxygen on drug-induced neuropathies in 22 patients with human immunodeficiency virus. all patients included in the study had been taking an antiretroviral medication for at least 12 months and had subjective symptoms of numbness or tingling, lethargy, and a decrease in deep tendon reflex. patients with an active substance abuse history or kaposi's sarcoma were excluded. of the 20 patients who completed the series, 17 had significant improvem ... | 1998 | 9640906 |
| multiple myeloma: vi international workshop, june 14-18, 1997, boston, massachusetts, usa. | the vi international workshop on multiple myeloma was organised by professor kenneth c anderson, dana farber cancer institute, and held on june 14-18, 1997, in boston, ma, usa. more than 500 participants from all over the world joined this workshop. several subjects were introduced and one of the most exciting items of news was the identification of kaposi's sarcoma-associated herpes virus in the bone marrow stromal cells of patients with mm. the aim of this overview is to give a glimpse of the ... | 1998 | 9643523 |
| immunosuppressive drugs and hhv-8 in a patient with a renal transplant and kaposi's sarcoma. | 1998 | 9643691 | |
| retinoids promising in kaposi's sarcoma trials. | 1998 | 9643704 | |
| the challenge of designing clinical trials for aids-related kaposi's sarcoma. | kaposi's sarcoma (ks) is a frequent cause of morbidity and mortality in patients with human immunodeficiency virus (hiv) infection. several characteristics of ks pose challenges for the conduct of clinical trials. kaposi's sarcoma patients often have multiple, irregularly shaped lesions, making accurate assessment of tumor size difficult. the lesions may have varying degrees of nodularity. involvement of the lung or other visceral organs often consists of multiple irregular lesions. conventional ... | 1998 | 9644686 |
| human herpesvirus 8 in italian hiv-seronegative patients with kaposi sarcoma. | to evaluate the prevalence of human herpesvirus 8 (hhv-8) dna detection in a large series of human immunodeficiency virus-seronegative patients with and without kaposi sarcoma (ks) from the central and southern regions of italy where classic ks is prevalent. | 1998 | 9645637 |
| prevalence of human herpesvirus 8 infection measured by antibodies to a latent nuclear antigen in patients with various dermatologic diseases. | human herpesvirus 8 (hhv-8) has been detected in all epidemiological forms of kaposi sarcoma (ks). the role of hhv-8 in dermatologic diseases other than ks is controversial. some studies based on polymerase chain reaction findings suggest an association between hhv-8 and epithelial tumors of the skin, lymphoproliferative disorders, or pemphigus. | 1998 | 9645638 |
| human herpesvirus 8 as the infectious cause of kaposi sarcoma: evidence and involvement of cofactors. | 1998 | 9645644 | |
| human herpesvirus 8 dna sequences in pemphigus: the role of the virus in oncogenic and autoimmune manifestations. | 1998 | 9645650 | |
| replication of bovine herpesvirus type 4 in human cells in vitro. | a reference strain (movár 33/63) of bovine herpesvirus type 4 (bhv-4) was inoculated into 14 different human cell lines and five primary cell cultures representing various human tissues. bhv-4 replicated in two embryonic lung cell lines, mrc-5 and wistar-38, and in a giant-cell glioblastoma cell culture. cytopathic effect and intranuclear inclusion bodies were observed in these cells. pcr detected a 10,000-times-higher level of bhv-4 dna. titration of the supernatant indicated a 100-fold increas ... | 1998 | 9650976 |
| in vivo inhibition of cc and cx3c chemokine-induced leukocyte infiltration and attenuation of glomerulonephritis in wistar-kyoto (wky) rats by vmip-ii. | chemokines play a central role in immune and inflammatory responses. it has been observed recently that certain viruses have evolved molecular piracy and mimicry mechanisms by encoding and synthesizing proteins that interfere with the normal host defense response. one such viral protein, vmip-ii, encoded by human herpesvirus 8, has been identified with in vitro antagonistic activities against cc and cxc chemokine receptors. we report here that vmip-ii has additional antagonistic activity against ... | 1998 | 9653095 |
| association of cutaneous and oral diseases in hiv-infected men. | mucocutaneous diseases are common in patients infected with human immunodeficiency virus (hiv). to identify cutaneous diseases for which hiv-infected people are at high risk, we sought those that are strongly associated with specific hiv-related oral lesions and with progression of hiv disease. | 1998 | 9655039 |
| [detection of human herpesvirus 8 in patients with kaposi's sarcoma or castleman's disease associated with aids]. | a new herpesvirus provisionally termed as kshv or hhv-8 has been detected in lesions from aids-based kaposi's sarcoma (ks) and from other ks clinical forms, and also in other tumors such as body cavity-based lymphomas or castleman's disease (cd). we have assessed the presence of this novel herpesvirus in specimens from patients diagnosed with either aids and ks or aids and cd. dna samples from skin lesions and peripheral blood obtained from 8 patients diagnosed with aids, seven with ks and one w ... | 1998 | 9656211 |
| blood dendritic cells from myeloma patients are not infected with kaposi's sarcoma-associated herpesvirus (kshv/hhv-8). | in recent studies, the sequence of kaposi's sarcoma-associated herpes virus (kshv) or human herpes virus-8 (hhv-8) was detected in dendritic cells (dc) of patients with multiple myeloma (mm). a concern was raised whether there is an causal association between the viral infection and development of these tumors. in the present study, we have examined dc generated from blood adherent cells from 8 swedish mm patients at different clinical stages and 2 patients with monoclonal gammopathy of undeterm ... | 1998 | 9657737 |
| the immunogenic glycoprotein gp35-37 of human herpesvirus 8 is encoded by open reading frame k8.1. | human herpesvirus 8 (hhv-8) is likely to be involved in the pathogenesis of kaposi's sarcoma (ks) and body cavity-based lymphomas (bcbls). the hhv-8 genome is primarily in a latent state in bcbl-derived cell lines like bcbl-1, but lytic replication can be induced by phorbol esters (r. renne, w. zhang, b. herndier, m. mcgrath, n. abbey, d. kedes, and d. e. ganem, nat. med. 2:342-346, 1996). a 35- to 37-kda glycoprotein (gp35-37) is the polypeptide most frequently and intensively recognized by ks ... | 1998 | 9658120 |
| human herpesvirus-8 in hematological diseases. | the huge amount of experimental and clinical observations supporting the possible involvement of human herpesvirus 8 (hhv-8) or kaposi sarcoma herpesvirus (kshv) in human lymphoproliferative diseases was critically reviewed during a workshop organized by the italian society for experimental hematology in florence, italy, on july 3rd, 1997. the organizers have prepared this report for the readers of haematologica. | 1998 | 9658733 |
| human herpes virus 8 (kaposi's sarcoma herpesvirus). | human herpes virus 8 (hhv-8) is a recently discovered herpesvirus related to herpesvirus saimiri and epstein-barr virus (ebv). it has been assigned to the rhadinovirus genus (gamma-2 herpesvirus) on the basis of its genomic sequence and structure. hhv-8 is the first member of this genus known to infect humans and it is now evident that it is the likely cause of kaposi's sarcoma (ks). the virus is present in endothelial and spindle cells of ks, and in hiv disease the presence of hhv-8 in peripher ... | 1998 | 9659514 |
| serologic evidence for mother-to-child transmission of kaposi sarcoma-associated herpesvirus infection. | 1998 | 9660357 | |
| retraction: is kaposi's sarcoma-associated herpesvirus in semen of hiv-infected homosexual men? | 1998 | 9660680 | |
| expression of the human herpesvirus 8-encoded viral macrophage inflammatory protein-1 gene in kaposi's sarcoma lesions. | 1998 | 9662209 | |
| classic kaposi's sarcoma in arabs living in israel, 1970-1993: a population-based incidence study. | the incidence of classic kaposi's sarcoma (cks) has been reported to be high in jewish populations living in israel and in immigrants originating from the mediterranean basin. no population-based reports are available on the incidence of cks in israeli arabs. we analyzed the incidence of cks cases occurring between 1970 and 1993 among arabs living in israel. reporting systems were the israel cancer registry, the medical documentation of all-kaposi's sarcoma cases and the registry of human immuno ... | 1998 | 9663588 |
| prevalence and determinants of anti-lytic and anti-latent antibodies to human herpesvirus-8 among italian individuals at risk of sexually and parenterally transmitted infections. | three hundred seventy-nine individuals [137 non-injecting drug using (non-idu) heterosexuals, 130 homosexual men and 112 idu] attending the human immunodeficiency virus (hiv) testing program of a sexually transmitted disease (std) clinic in rome were studied to estimate the prevalence and to identify the modalities of transmission of human herpesvirus-8 (hhv-8) infection. serological analysis was performed by using an immunofluorescence assay able to detect anti-latent and anti-lytic hhv-8 antib ... | 1998 | 9663596 |
| human herpesvirus 8 seroprevalence in sardinia. | 1998 | 9665151 | |
| no association between human herpesvirus type 8 infection and multiple myeloma. | 1998 | 9665152 | |
| detection and semiquantitative analysis of human herpesvirus 8 dna in specimens from patients with kaposi's sarcoma. | kaposi's sarcoma (ks) is the most common neoplasm in patients with aids. epidemiologic evidence and the recent identification of herpesvirus-like dna sequences in patients with ks have suggested a role for viral agents in the etiopathogenesis of this disease. it is unclear if these sequences are present in all types of ks and if the copy number of these sequences has a correlation with disease severity (staging). in order to clarify these issues, we retrospectively analyzed, by pcr and southern ... | 1998 | 9665995 |
| role of viral agents in the pathogenesis of kaposi's sarcoma. | several viruses have been detected, at various frequencies, in kaposi's sarcoma (ks) tissues. the detection of human herpesvirus 8 (hhv-8) in all the epidemiological and histological forms of ks makes it the most attractive candidate causative agent to date. in this report, we discuss the possible explanations for the detection of genomic sequences of various viral agents in ks and the putative role of those viruses in the pathogenesis of the disease. | 1998 | 9669127 |
| human interferon-gamma-inducible protein 10 (ip-10) inhibits constitutive signaling of kaposi's sarcoma-associated herpesvirus g protein-coupled receptor. | a g protein-coupled receptor (gpcr) is encoded within the genome of kaposi's sarcoma- associated herpesvirus (kshv)/human herpesvirus 8, a virus that may be involved in the pathogenesis of kaposi's sarcoma and primary effusion lymphomas. kshv-gpcr exhibits constitutive signaling activity that causes oncogenic transformation. we report that human interferon (ifn)-gamma-inducible protein 10 (huip-10), a c-x-c chemokine, specifically inhibits signaling of kshv-gpcr. in contrast, monokine induced by ... | 1998 | 9670053 |
| do viral chemokines modulate kaposi's sarcoma? | kaposi's sarcoma (ks) is an angiogenic tumor of mixed cellularity most commonly found in homosexual men infected with hiv. both molecular and epidemiologic evidence has linked a newly described herpesvirus to this disease. this virus, kaposi's sarcoma-associated herpesvirus (kshv), encodes a number of cellular homologues, including two genes that share remarkable similarity to the human chemokine macrophage inhibitory factor-1 alpha. recently, studies have begun to shed light on the roles these ... | 1998 | 9670810 |
| age- and sex-specific seroprevalence of human herpesvirus 8 in jamaica. | 1998 | 9672261 | |
| shedding of cytomegalovirus and herpesviruses 6, 7, and 8 in saliva of human immunodeficiency virus type 1-infected patients and healthy controls. | we used the polymerase chain reaction to study the presence of dna from cytomegalovirus (cmv) and human herpesvirus (hhv)-6, hhv-7, and hhv-8 in saliva from 44 human immunodeficiency virus (hiv) type 1-infected patients at different stages of disease and in 15 healthy hiv-seronegative controls. cmv dna, hhv-6 dna, and hhv-7 dna were found in all groups, but hhv-8 dna was found only in symptomatic hiv-1-infected patients (5 [17%] of 29). one of the patients with hhv-8 dna in saliva had oral kapos ... | 1998 | 9675467 |
| epstein-barr virus infections and their association with human malignancies: some key questions. | epstein-barr virus (ebv) expresses genes that stimulate cells to divide in culture. this property, coupled with the close association of the virus with numerous malignancies, has prompted its designation as a human dna tumour virus. before human herpesvirus 8 (hhv-8, alternatively ks virus) was discovered, ebv was unique in this property among the human herpesviruses. ebv infection has been best characterised in terms of gene expression in b lymphocytes and epithelium, which represent cells foun ... | 1998 | 9677010 |
| risk factors for kaposi's-sarcoma-associated herpesvirus (kshv/hhv-8) seropositivity in a cohort of homosexual men, 1981-1996. | a newly identified herpesvirus has been associated with kaposi's sarcoma. we determined risk factors for kaposi's-sarcoma-associated herpesvirus/human herpesvirus 8 (kshv/hhv-8) seropositivity and incidence of infection over time in a cohort of danish homosexual men followed from 1981 to 1996. antibodies to a latent nuclear (lana) and a structural (orf65) antigen of kshv/hhv-8 were measured by immunofluorescence and elisa/wb respectively. through linkage with the national aids registry, all coho ... | 1998 | 9679756 |
| re: kaposi's sarcoma associated herpesvirus deoxyribonucleic acid sequences: lack of detection in prostatic tissue of human immunodeficiency virus-negative immunocompetent adults. | 1998 | 9679915 | |
| kaposi's sarcoma-associated herpesvirus (human herpesvirus-8). | 1998 | 9680119 | |
| epidemiology and pathogenesis of aids-related lymphomas. | among patients with congenital and acquired immunodeficiencies, non-hodgkin's lymphoma (nhls ) are the most common tumors of the immune system. in the setting of human immunodeficiency virus (hiv) infection, as many as 10% to 20% of people ultimately developed nhls. these tumors are clinically aggressive, frequently involve extranodal sites, and often exhibit unique features that distinguish them from nhl arising in individuals with other forms of immunosuppression. important in the development ... | 1998 | 9684278 |
| renal pathology of human immunodeficiency virus infection. | renal complications of hiv infection are clinically and morphologically diverse. these may affect the glomerular, tubulointerstitial, and vascular compartments. tubulointerstitial injury predominates in most autopsy-based studies, whereas glomerular disease is most frequently identified in biopsy-based studies. the most common glomerular lesion is hiv-associated focal segmental glomerulosclerosis and related mesangiopathies (collectively termed hiv-associated nephropathy). increasingly, a variet ... | 1998 | 9692353 |
| body-cavity-based lymphoma in an elderly aids-unrelated male. | body-cavity-based lymphoma (bcbl) is a recently described subtype of human non-hodgkin's lymphoma characterized by the localization of neoplastic cells exclusively in the body cavities. bcbl is found most commonly in aids patients, and is known to be highly associated with kaposi's sarcoma-associated herpes virus (kshv). we describe here a case of bcbl that occurred in a 101-year-old man. he was successively treated with etoposide, but died 8 months after the diagnosis of bcbl. no lymphoma masse ... | 1998 | 9695416 |
| interassay correlation of human herpesvirus 8 serologic tests. hhv-8 interlaboratory collaborative group. | to standardize human herpesvirus 8 (hhv-8) antibody assays for application to asymptomatic infection, a blinded comparison was done of seven immunofluorescence assays and elisas. five experienced laboratories tested a serum panel from 143 subjects in 4 diagnostic groups. except for a minor capsid protein elisa, the other six tests detected hhv-8 antibodies most frequently in classic (80%-100%) and aids-related (67%-91%) kaposi's sarcoma, followed by human immunodeficiency virus-seropositive pati ... | 1998 | 9697708 |
| clinical efficacy of high-dose acyclovir in patients with human immunodeficiency virus infection: a meta-analysis of randomized individual patient data. | a meta-analysis of 8 randomized trials (1792 patients, 2947 patient-years of follow-up) showed that acyclovir (> or = 3200 mg/day) offered a significant survival benefit (p = .006 by log-rank test) in human immunodeficiency virus (hiv) infection. the treatment effect did not vary significantly in patient subgroups of different cd4 cell counts, hemoglobin levels, age, race, and sex, and with or without aids diagnosis. acyclovir treatment (hazard ratio, 0.78; 95% confidence interval [ci], 0.65-0.9 ... | 1998 | 9697714 |
| human herpesvirus 8 as a potential sexually transmitted agent in honduras. | the seroprevalence of human herpesvirus 8 (hhv-8) was studied in 326 human immunodeficiency virus (hiv)-positive and -negative persons from honduras; women constituted 77% (n = 251) of the subjects. sera were tested for lytic hhv-8 antibodies by an ifa, and positive samples were confirmed by a radioimmunoprecipitation assay. of the 326 persons tested, 58 (17.8%) had hhv-8 antibodies. among the hiv-infected women, 22.7% were seropositive; 11.3% of the hiv-negative women were seropositive. hhv-8 s ... | 1998 | 9697741 |
| immune dysfunction and the pathogenesis of aids-associated non-hodgkin's lymphoma. | much has been learned about how hiv-induced immune dysfunction contributes to b cell hyperactivation, and potentially, to the pathogenesis of aids-lymphoma. however, further studies are needed to fully understand how hiv infection and immune dysfunction promote b cell hyperactivation and the development/growth of aids-lymphoma. in particular, studies are needed to define the role of hhv8 vil6, il6 receptor-expression, and lymphocyte surface stimulatory molecules, in promoting b cell hyperactivat ... | 1998 | 9698872 |
| primary-effusion lymphoma and kaposi's sarcoma in a cardiac-transplant recipient. | 1998 | 9700178 | |
| detection and subtyping of human herpesvirus-8 in renal transplant patients before and after remission of kaposi's sarcoma. | kaposi's sarcoma (ks) is a complication of renal transplantation. if the human herpesvirus-8 (hhv-8) causes ks, the virus should be present in all ks lesions and be drastically reduced or cleared from involved tissue on remission of the ks. | 1998 | 9701267 |