Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| a microrna screen identifies the wnt signaling pathway as a regulator of the interferon response during flavivirus infection. | the impact of mosquito-borne flavivirus infections worldwide is significant, and many critical aspects of these viruses' biology, including virus-host interactions, host cell requirements for replication, and how virus-host interactions impact pathology, remain to be fully understood. the recent reemergence and spread of flaviviruses, including dengue virus (denv), west nile virus (wnv), and zika virus (zikv), highlight the importance of performing basic research on this important group of patho ... | 2017 | 28148804 |
| the chimeric japanese encephalitis/dengue 2 virus protects mice from challenge by both dengue virus and jev virulent virus. | 2017 | 28124229 | |
| honeysuckle aqueous extract and induced let-7a suppress dengue virus type 2 replication and pathogenesis. | honeysuckle (lonicera japonica thunb.), a traditional chinese herb, has widely been used to treat pathogen infection. however, the underlying-mechanism remains elusive. | 2017 | 28052239 |
| fatal invasive aspergillosis: a rare co-infection with an unexpected image presentation in a patient with dengue shock syndrome. | pulmonary infiltration and pleural effusion caused by permeability syndrome are the hallmark of pulmonary manifestation of dengue cases. | 2017 | 26072955 |
| mild encephalitis/encephalopathy with reversible splenial lesion (mers) due to dengue virus. | a 14-year-old girl presented with encephalopathy, delirium and ophthalmoplegia following a 3day history of high-grade fever. brain mri on day 6 of illness showed diffusion restricted ovoid lesion in the splenium of corpus callosum. dengue virus encephalitis was diagnosed with positive pcr for dengue virus type-2 in both serum and cerebrospinal fluid. she made a complete recovery from day 10 of illness. repeat brain mri on day 12 of illness showed resolution of the splenial lesion. serial diffusi ... | 2017 | 27887978 |
| antiviral activities of selected antimalarials against dengue virus type 2 and zika virus. | in a previous study, twelve antimalarial compounds, amodiaquine (aq) and derivatives, were shown to have potent anti-dengue viral (denv) activity by using the stable denv2 renilla luciferase reporter replicon expressing bhk-21 cells, infectivity (plaque), and the qrt-pcr assays. in this study, we performed molecular modeling on these compounds to determine their stereo-electronic properties required for optimal antiviral activity. based on the similarity of calculated stereo-electronic profiles, ... | 2017 | 27889529 |
| global evolutionary history and spatio-temporal dynamics of dengue virus type 2. | denv-2 spread throughout the tropical and subtropical regions globally, which is implicated in deadly outbreaks of dhf and dss. since dengue cases have grown dramatically in recent years, about half of the world's population is now at risk. our timescale analysis indicated that the most recent common ancestor existed about 100 years ago. the rate of nucleotide substitution was estimated to be 8.94 × 10(-4) subs/site/year. selection pressure analysis showed that two sites 160 and 403 were under p ... | 2017 | 28378782 |
| transcriptome analysis of aedes aegypti in response to mono-infections and co-infections of dengue virus-2 and chikungunya virus. | chikungunya virus (chikv) and dengue virus (denv) spread via the bite of infected aedes mosquitoes. both these viruses exist as co-infections in the host as well as the vector and are known to exploit their cellular machinery for their replication. while there are studies reporting the changes in aedes transcriptome when infected with denv and chikv individually, the effect both these viruses have on the mosquitoes when present as co-infections is not clearly understood. in the present study, we ... | 2017 | 28161634 |
| butyrolactones and diketopiperazines from marine microbes: inhibition effects on dengue virus type 2 replication. | two new compounds, 4s,10r-dihydroxy-11-methyl-dodec-2-en-1,4-olide (1) (butyrolactone-type) and cyclo-(4-trans-6-dihydroxy-proline-d-leucine) (2) (diketopiperazine-type), as well as one known 4s,10-dihydroxy-10-methyl-dodec-2-en-1,4-olide (3) and three known diketopiperazines, cyclo-(l-proline-l-leucine) (4), cyclo-(4-trans-hydroxy-l-proline-l-leucine) (5), and cyclo-(4-trans-hydroxy-l-proline-l-phenylalanine) (6), were isolated from the ethyl acetate extracts of streptomyces gougerotii gt and m ... | 2017 | 27542174 |
| identification of fused bicyclic derivatives of pyrrolidine and imidazolidinone as dengue virus-2 ns2b-ns3 protease inhibitors. | a series of fused ring derivatives of pyrrolidine and imidazolidinone were designed, synthesized, characterized and assayed against the denv-2 ns2b-ns3 protease and wild-type denv-2 virus. the linear dipeptide compound 1 and the non-peptidic fused ring compound 2 show comparable activities against denv-2 ns2b-ns3 protease and wild-type denv-2 virus in a viral replication assay. the preliminary sar reveals that a substituent and its stereochemistry at c-3 position, substitution (x) at n-2 arene a ... | 2017 | 27721158 |
| neutralizing antibodies against flaviviruses, babanki virus, and rift valley fever virus in ugandan bats. | introduction:a number of arboviruses have previously been isolated from naturally-infected east african bats, however the role of bats in arbovirus maintenance is poorly understood. the aim of this study was to investigate the exposure history of ugandan bats to a panel of arboviruses.materials and methods:insectivorous and fruit bats were captured from multiple locations throughout uganda during 2009 and 2011-2013. all serum samples were tested for neutralizing antibodies against west nile viru ... | 2018 | 29511459 |
| genotype-specific and cross-reactive neutralizing antibodies induced by dengue virus infection: detection of antibodies with different levels of neutralizing activities against homologous and heterologous genotypes of dengue virus type 2 in common marmosets (callithrix jacchus). | a vaccine against all four dengue virus (denv) serotypes includes the formulation of one genotype of each serotype. although genetic similarities among genotypes within a serotype are higher as compared to those among serotypes, differences in the immunogenicity of the included genotypes would be a critical issue in maximizing successful dengue vaccine development. thus, we determined the neutralizing antibody responses against three genotypes of dengue virus serotype 2 (denv-2), namely cosmopol ... | 2018 | 29587780 |
| pirna profiling of dengue virus type 2-infected asian tiger mosquito and midgut tissues. | the asian tiger mosquito, aedes albopictus, is a competent vector for the majority of arboviruses. the mosquito innate immune response is a primary determinant for arthropod-borne virus transmission, and the midgut is the first barrier to pathogen transmission. mosquito antiviral immunity is primarily mediated by the small interfering rna pathway. however, the roles that the p-element induced wimpy testis (piwi)-interacting rna (pirna) pathway play in antiviral immunity in ae. albopictus and its ... | 2018 | 29690553 |
| the reintroduction of denv-2 in 2011 in panama and subsequent outbreak characteristic. | the circulation of the south-east asian/american (as/am) dengue 2 virus (denv-2) genotype in the americas has been associated with a high rate of severe disease. from 1993, the year denv was reintroduced in panama, until 2011 there were 29 dengue-associated deaths, 17 of which occurred in 2011, the most severe outbreak with a case fatality rate (cfr) of 44% (17 deaths out of 38 severe dengue cases). during this outbreak denv-2 was reintroduced into the country, whereas over the prior five years ... | 2018 | 28986247 |
| the antimicrobial peptide hs-1 inhibits dengue virus infection. | dengue virus (denv) is an arbovirus that belongs to the flaviviridae family. studies reveal that peptides secreted by amphibians have many functions, such as antiviral and antimicrobial activities. as there is no antiviral drug effective against the denv, the antiviral activity of a synthetic peptide called hs-1, derived from the secretion of the anuran hypsiboas semilineatus, has been evaluated. the assays of neutralization in the vero cells show a complete inhibition of infection of the seroty ... | 2018 | 29153860 |
| extensive genomic recoding by codon-pair deoptimization selective for mammals is a flexible tool to generate attenuated vaccine candidates for dengue virus 2. | the four serotypes of dengue virus (denv) are the leading etiologic agent of disease caused by arthropod-borne viruses (arboviruses) in the world, with billions at risk of denv infection spread by infected mosquitoes. denv causes illness ranging from dengue fever (df) to life-threatening dengue hemorrhagic fever (dhf) and dengue shock syndrome (dss). denv proliferates well in two different host systems, an invertebrate mosquito vector and vertebrate primate host, which have a distinct difference ... | 2019 | 31539771 |
| in-vitro and in silico activity of cyamopsis tetragonoloba (gaur) l. supercritical extract against the dengue-2 virus. | our health and wealth are highly influenced by a number of viruses. dengue is one of them having a global influence in absence of vaccines and antiviral. who suggested that the morbidity of dengue is increasing more than 6 times from 0.5 million in 2010 to over 3.34 million in 2016, following a sharp increase in 2019. the aim of the present study is to check the in vitro and in silico anti-dengue activity of cyamopsis tetragonoloba supercritical extract in cell lines. the optimum yield of superc ... | 2020 | 32904730 |
| two cases of natural infection of dengue-2 virus in bats in the colombian caribbean. | dengue, a mosquito-borne zoonotic disease, is the most common vector-borne disease in tropical and subtropical areas. in this study, we aim to demonstrate biological evidence of dengue virus infection in bats. a cross-sectional study was carried out in the departments of cordoba and sucre, colombia. a total of 286 bats were captured following the ethical protocols of animal experimentation. the specimens were identified and euthanized using a pharmacological treatment with atropine, acepromazine ... | 2021 | 33809400 |