Publications

alterations of human serum proteins and other biochemical parameters after five to ten days of untreated acute falciparum malaria.	untreated malaria for more than 4 days in eleven patients decreased significantly prealbumin, transferrin levels and increased sgot activity when compared with a control group and a group of 10 malaria patients who were admitted to the hospital at an earlier stage of the infection. total protein was significantly lower in the group of patients admitted after five to ten days to hospital compared with the control group. in all malaria patients independent of the duration of the acute infection th ...	1977	333673
plasmodium falciparum in culture: use of outdated erthrocytes and description of the candle jar method.		1977	335035
[present-day problems of malaria. recent acquisitions in immunology].		1977	335485
[clinical aspects of malalaria in france].		1977	335486
[glomerular renal disease and malaria].		1977	335487
intestinal and blood parasites in the north lore district, central sulawesi, indonesia.	over 1,000 stool specimens from residents of the napu and besoa valleys, central sulawesi, indonesia were examined. schistosoma japonicum was detected in 31% of napu valley residents while in only 2% of the besoa valley residents. hookworm infections were the most frequently encountered helminth parasitisms in both valleys. other helminth parasites encountered were: ascaris lumbricoides, trichuris trichiura, enterobius vermicularis, strongyloides stercoralis, physaloptera sp., diphyllobothrium s ...	1977	335530
[fatal course of tropical malaria with consumption coagulopathy].		1977	337040
[identification of plasmodial antibodies in the immunodiagnosis of malaria (author's transl)].	out of 880 sera which were examined for antibodies to plasmodia 69 (7.8%) reacted only with p. falciparum antigen, 371(42.2%) reacted only with p. fieldi antigen, and 440 (50%) responded to both antigens. these groups were differentiated further with antigens from p. vivax, p. ovale, and p. malariae. the results showed that the p. ovale antigen was distinguished by a marked activity with those sera that had reacted only with p. fieldi in the screening test. with sera that had responded to both a ...	1977	337074
effects of foetal haemoglobin on susceptibility of red cells to plasmodium falciparum.		1977	337159
[falciparum malaria in switzerland: a problem of intensive care?].	in the period 1972-1976, 5 of 17 patients admitted to the cantonal hospital, basel, for falciparum malaria had to be treated in the intensive care unit. two patients died. none had performed regular chemoprophylaxis and in all of them several days had elapsed between onset of symptoms and diagnosis. the importance of information on malaria to tourists and physicians is stressed.	1977	337475
invasion and growth of plasmodium falciparum in different types of human erythrocyte.	the susceptibility of human red blood cells to invasion by plasmodium falciparum was investigated in microtissue cultures with different populations of erythrocytes containing fetal haemoglobin (hbf). preferential invasion of hbf-containing erythrocytes was observed with umbilical cord blood. the parasites showed no preference for hbf cells in blood from a subject with hereditary persistence of fetal haemoglobin (hpfh). by contrast, a significant preference for hba-containing erythrocytes was fo ...	1977	338178
a histidine-rich protein from plasmodium falciparum and its interaction with membranes.	in previous studies, an unusual protein with 70% of histidine was isolated from plasmodium lophurae. it was shown to have a possible function in the penetration of merozoites into erythrocytes. the results of the present study indicate the presence of a similar histidine-rich protein in plasmodium falciparum. like that of p. lophurae, the histidine-rich protein of p. falciparum is acid-soluble, but it has a slightly higher molecular weight.	1977	338179
ultrastructure and viability of cryopreserved plasmodium falciparum.	cryopreserved chimpanzee erythrocytes infected with plasmodium falciparum were examined by electron microscopy directly and after a period of culture. light microscopic observations on the viability of cryopreserved parasites in culture were also made. parasitaemia data from a chimpanzee infected with parasites cryostored for more than 2(1/2) years are presented. varying degrees of damage were apparent as the parasites were examined in vitro, for viability, and by electron microscopy. schizonts ...	1977	338185
cultivation of erythrocytic stages.	two methods are described for the continuous cultivation of plasmodium falciparum. one method provides for a continuous slow flow of medium over a settled layer of blood cells and does not require daily attention. with the other method, carried out in petri dishes, the medium has to be changed manually every day. the problems and possibilities of continuous cultivation are discussed.	1977	338187
gametogenesis in culture by gametocytes of plasmodium falciparum.		1977	339101
the duffy blood group and malaria prevalence in gambian west africans.	erythrocytes from 1,168 donors, comprising almost the entire populations of two rural gambian villages, have been tested for duffy blood group antigens using antisera to both fya and fyb. all tests were negative. blood film examination of the same samples showed complete absence of plasmodium vivax parasitaemia, but infections with p. falciparum,p. malariae and p. ovale were observed. the findings are consistent with the view that the duffy-negative phenotype, fyfy, constitutes the basis of inna ...	1977	339418
the treatment of severe falciparum malaria.	in severe falciparum malaria there is a pathophysiological cascade beginning with changes in the parasitized red blood cells which induce intermediate effects, in turn contributing to dysfunction of several organs. a low serum albumin is a common but often unrecognized finding which may contribute to oedema especially in the lung and brain. the only irreversible complication in falciparum malaria is the acute respiratory distress syndrome, manifested by cyanosis and rapid breathing, basically di ...	1977	339421
biochemical markers for strain differentiation in malarial parasites.	genetic differences between micro-organisms can be identified by studying variations in enzyme forms and dna characteristics. enzyme electrophoresis has revealed considerable genetic diversity in populations of malarial parasites and has enabled populations reproductively isolated from one another to be identified. studies on rodent malarial parasites from four regions of africa have shown that each species and subspecies can be distinguished by its pattern of enzyme forms. in subspecies in whic ...	1977	303952
biomedical survey in irian jaya (west irian), indonesia.	a biomedical survey was conducted in several areas of irian jaya, indonesia in july 1972 in association with an investigation of reports of a cholera outbreak. stool specimens, blood smears and sera were collected and examined for evidence of parasitic as well as other infectious diseases. a total of 114 stools were examined and the most commonly found intestinal parasites were trichuris trichiura (94%), ascaris lumbricoides (74%), hookworm (58%), entamoeba coli (15%), endolimax nana (8%), entam ...	1977	208184
[relations between malaria and burkitt's lymphoma].	malaria, especially forest malaria, is the environmental factor which creates endemic conditions for the esptein-barr virus related burkitt's lymphoma. the plasmodium seems active through a mitogenic factor rather than through the so often invoked immunological depresssion.	1977	208788
the seroepidemiology of malaria in middle america. iv. passage of malaria antibodies from mothers to infants.	in an area of el salvador moderately endemic for malaria, use of the indirect fluorescent antibody test (ifa) showed that 44% of the infants born to mothers who had ifa responses to plasmodium vivax of 1:20 or higher during the latter part of their pregnancy had positive ifa responses of 1:10 or higher to this antigen. no serum from an infant was positive in the absence of some level of malarial response in the mother.	1977	339753
chemosuppressive field trials in thailand. iii. the suppression of plasmodium falciparum and plasmodium vivax parasitemias by a sulfadoxine-pyrimethamine combination.		1977	339754
in vivo and in vitro studies of chloroquine-resistant malaria in thailand.	fourteen patients infected with falciparum malaria admitted to the hospital for tropical diseases in bangkok, faculty of tropical medicine, mahidol university, were studied. in vivo and in vitro methods were used to compare the effects of chloroquine on plasmodium falciparum. the results showed that ri in vivo corresponded to samples containing chloroquine base 2.5-3.5 millimicromoles per ml of blood in vitro and rii in vivo corresponded to samples with chloroquine base of 4.0 millimicromoles pe ...	1977	339855
prevalence of erythrocyte g6pd deficiency in sabah.		1977	340882
malaria cases observed in gdańsk in 1973-1977.		1977	342009
chloroquine resistant plasmodium falciparum in thailand: susceptibility of anopheles.		1977	342649
response of falciparum malaria to a standard regimen of chloroquine in vientiane, lao people's democratic republic.		1977	342718
[recrudescence of imported malaria (author's transl)].	in the light of two recent cases of severe central nervous system malaria due to neglect in chemoprophylaxis, the authors report the very marked recrudescence in imported malaria and draw attention to the frequency of cases due to p. falciparum, the agent of malignant tertian fever and of malignant episodes. the necessity of early diagnosis in such cases is mentioned, together with the treatment of simple malaria and, in particular, of malignant varieties. in order to be effective, chemoprophyla ...	1977	343066
plasmodium falciparum gametocytes: the effect of chloroquine on their development.	asexual erythrocytic parasites of plasmodium falciparum are killed by chloroquine, whilst mature gametocytes are not. the gametocytes of p. falciparum take 10 days to develop to maturity and their sensitivity to chloroquine during this time was studied in vitro to investigate when the switch from susceptibility to insusceptibility occurred and to compare the responses of asexual and immature sexual parasites to the drug. 45 to 50% of asexual parasites and immature gametocytes less than one day o ...	1977	343314
an unusual macular lesion associated with malaria.	a case of a young man afflicted with falciparum malaria is presented in which the primary ocular finding was a subpigment epithelial hemorrhage involving the macula. previous reports in the literature concentrate on peripheral and central retinal hemorrhages, almost to the exclusion of choroidal vascular abnormalities. the value of this case lies in the recognition that the choroid can assume an important role in fundus abnormalities associated with malaria, probably on the basis of obstructive ...	1977	343689
response of p. vivax and p. falciparum cases to presumptive treatment with chloroquine in some districts of karnataka.		1977	346479
pathophysiology of atypical malaria.		1977	348670
[parasitological diagnosis of malaria by concentration of parasitized erythrocytes: technic and preliminary results].		1977	354817
where are you going.		1977	319727
chloroquine-resistant falciparum malaria from papua new guinea and its implications for australia.	there is need for effective chemoprophylaxis against chloroquine-resistant falciparum malaria, and for a safe and effective drug to be readily available for the treatment of that condition. experience with the cases cited in this study indicates that fansidar should be made available for treatment and it is suggested that maloprim be made available as a prophylactic agent.	1977	320435
plasmodium falciparum gametocytes: their longevity and infectivity.	the longevity and infectivity of isolated populations of plasmodium falciparum gametocytes were studied. following chloroquine treatment gametocyte numbers fell with a constant rate of loss over a period of 16-24 days; the populations had a half-life of 2-4 days. the sex ratio stayed constant throughout at 4 female: 1 male. the ability of the microgametocytes to exflagellate and the infectivity of the population to mosquitoes persisted for 3 weeks. antibodies to the gametocytes were detected but ...	1977	320542
[differential diagnostic problems in the recognition of severe infections with plasmodium falciparum].		1977	347783
venezuelan strains of plasmodium falciparum resistant to sulfa and pyrimethamine as demonstrated by in vitro test.		1977	368932
[2 cases of plasmodium falciparum malaria. probable responsibility of anopheles transported by air].	report of two cases of plasmodium falciparum malaria which seem to be originary from the pariser area: the first one in a luggage carrier working in an airport; the second one in a subject living in the neighbourhood of this airport. these cases perhaps question the hygiene measures taken on the arrival of planes coming from impalutaded regions.	1977	352558
[a probable laboratory contamination with plasmodium falciparum].	a student working in a medical biology department presented a severe plasmodium falciparum malaria, with high thrombopenia, hypercalcemia and hypophosphoremia. the mode of infection seems to be a laboratory contamination with a highly contaminated blood sample through skin excoriations.	1977	352557
[post-transfusion pernicious plasmodium falciparum attack in a patient with renal insufficiency].	the authors report one case of transfusion induced falciparum cerebral malaria. among the parasites responsible for transfusion malaria, plasmodium falciparum is rarely implicated, but may be accompanied by serious complications. different ways of artificial transmission of the parasites are reported. clinical findings are few, so the examination of blood films is essential for diagnostic. the dangerous blood donor must be identified by immunofluorescent methods. the specific treatment is quinin ...	1977	352559
studies on the nature of thyroidal suppression during acute falciparum malaria: integrity of pituitary response to trh and alterations in serum t3 and reverse t3.	the nature of the suppression of the pituitary-thyroid axis during infection was studied by testing the integrity of thyrotropin (tsh) and prolactin (prl) responses to thyrotropin-releasing hormone (trh) during acute falciparum malaria in human volunteers. during infection, tsh responses to trh were found to be intact while prl secretion was slightly increased. that serum t3 levels abruptly declined during infection while serum t4 was stable or increasing suggested an alteration in peripheral de ...	1977	401826
intestinal and blood parasites in the banggai kabupaten, central sulawesi, indonesia.	a survey for blood and intestinal parasites was carried out in the banggai kabupaten central sulawesi, indonesia. a total of 336, stool specimens were obtained from 182 males and 154 females ranging in age from 2 to 90 years. hookworm, trichuris trichiura and ascaris lumbricoides were the most common helminths encountered. schistosoma japonicum was noticeably absent in the population sampled. the following intestingl protozoa were detected: entamoeba coli, e.histolytica, iodamoeba bütschlii, gia ...	1977	607427
parasites of man in remote areas of central and south sulawesi, indonesia.	a biomedical survey was conducted in 10 villages in remote, high mountain valleys of central and south sulawesi, indonesia to learn whether oriental schistosomiasis was endemic and to determine the prevalences of other intestinal parasites, malaria and filariasis in those areas. although persons with oriental schistosomiasis were found in three villages of south sulawesi, follow-up inquiries revealed that these had recently migrated from a known schistosomiasis area in central sulawesi. other in ...	1977	607428
drug-resistant malaria.		1977	402541
sporozoite transmission of falciparum malaria (burma-thau. strain) from man to aotus monkey.	a sporozoite-induced infection of plasmodium falciparum (burma-thau. strain) was established in splenectomized aotus trivirgatus which received prior treatment with dlmethionine as a dietary supplement. this is the first recorded instance of infection of an aotus monkey with falciparum sporozoites of human origin.	1977	402864
studies on the santa lucia (el salvador) strain of plasmodium falciparum in aotus trivirgatus monkeys.	the santa lucia strain of plasmodium falciparum was isolated from el salvador, central america, and established in aotus trivirgatus monkeys. transmission from monkey to monkey via the bites of infected anopheles freeborni, a. maculatus, and a, albimanus mosquitoes was obtained in 20 of 27 attempts. prepatent periods in the monkeys ranged from 17 to 46 days with a mean of 24.3 days. parasitemias and mortality were higher following sporozoite inoculation into animals which had been previously inf ...	1977	403272
infectivity of the santa lucia (el salvador) strain of plasmodium falciparum to different anophelines.	anopheles freeborni mosquitoes were much more heavily infected with the santa lucia strain of plasmodium falciparum from coastal el salvador than were any of the other species tested. of 5 strains of a. albimanus examined, the most heavily infected was the ca-109a and the least was the melara, both of which come from coastal el salvador. of the exotic anophelines, the a. maculatus was infected at a slightly higher level than was the a. balabacensis. the incidence of highly infected individual mo ...	1977	403273
plasmodium falciparum and plasmodium coatneyi: immunogenicity of "knob-like protrusions" on infected erythrocyte membranes.		1977	405234
an effective immunization of experimental monkeys against a human malaria parasite, plasmodium falciparum.	this is the first report of successful immunization of experimental monkeys against a human malaria parasite, plasmodium falciparum. of the five owl monkeys (aotus trivirgatus) used in this pilot study, two served as controls and the other three were immunized with p. falciparum antigen consisting primarily of mature segmenters containing fully developed merozoites. two injections of antigen emulsified with freund's complete adjuvant were administered intramuscularly 3 weeks apart. three weeks a ...	1977	406671
activities of various 4-aminoquinolines against infections with chloroquine-resistant strains of plasmodium falciparum.	the studies reported here stemmed from a personal report by geiman on the capacity of the 4-aminoquinoline amodiaquin to inhibit in vitro maturation of ring stages of the chloroquine-resistant monterey strain of plasmodium falciparum. this observation, confirmed in owl monkeys infected with this strain, led to a comparison of the activities of chloroquine, amodiaquin, amopyroquin, and dichlorquinazine (12,278 rp) against infections with various chloroquine-susceptible and chloroquine-resistant s ...	1977	406829
quantitative aspects of pyrimethamine-sulfonamide synergism.	the experiments described in this report have dealt with the dimensions of therapeutic potentiation achieved when combinations of pyrimethamine and sulfadiazine were administered to rhesus monkeys infected with a drug-susceptible strain of plasmodium cynomolgi or its pyrimethamine-resistant variant and to owl monkeys infected with strains of p. falciparum and p. vivax of varying degrees of resistance to this pyrimidine. these evaluations showed: 1) that when delivered in combination, the activit ...	1977	410317
hypothesis on the mechanism of erythrocyte invasion by malaria merozoites.	plasmodium knowlesi merozoites invade erythrocytes by a sequence of events: attachment, widespread deformation of the erythrocyte membrane, endocytosis, and resealing of the membrane and vesicle. the possible mechanisms by which these events occur are discussed. in particular, there is a detailed discussion of the role of the duffy blood group system in invasion.	1977	412599
an effective immunization of aotus trivirgatus monkeys against plasmodium falciparum: a research note.		1977	412606
effects of autologous plasma on lymphocyte transformation in malaria and in acute protein-energy malnutrition. comparison of purified lymphocyte and whole blood cultures.	phytohaemagglutinin (pha) induced lymphocyte transformation in whole blood and in purified lymphocyte cultures was investigated in gambian children with acute plasmodium falciparum malaria or with acute protein-energy malnutrition (pem). responses of purified lymphocytes cultured in the absence of autologous plasma were normal, with one exception. autologous plasma depressed the response of purified lymphocytes to a low dose of pha in several malaria and pem patients. in whole blood cultures of ...	1977	412777
immunoprophylaxis of malaria: sporozoite-induced immunity.		1977	413344
erythrocyte receptors for malaria merozoites.		1977	413448
malaria eradication in portugal.	research on malaria, which was endemic in several parts of portugal at the beginning of this century, was intensified in the 1940's and led to the development of better control methods, especially in the rice-growing areas of the country. in the 1950's residual ddt spraying was introduced and followed by extensive detection of cases of malaria and their treatment. plans for eradication of the disease were made, and by 1958 the transmission of the infection was interrupted in nearly all areas of ...	1977	888169
spleen-derived mononuclear cell chemotactic factor in malaria infections: a possible mechanism for splenic macrophage accumulation.		1977	402418
malarial antibodies in tropical splenomegaly syndrome in papua new guinea.	levels of species and class-specific malarial antibody were studied in 249 new guineans with tropical splenomegaly syndrome (tss) and in 87 control subjects living in the same area. titres of igg and igm antibody to plasmodium falciparum, p. vivax and p. malariae were estimated by indirect immunofluorescence. both ig and igm antibody levels were higher in subjects with tss than in controls; igm titres were highest in those with the greatest splenic enlargement. responses to all three species wer ...	1977	595079
in vitro cultivation and partial purification of plasmodium falciparum antigen suitable for vaccination studies in aotus monkeys.		1978	415127
selection of increased quinine resistance in plasmodium falciparum in aotus monkeys.	although partial resistance (ri) of plasmodium falciparum to quinine is common in some areas of the world, failure to obtain an initial response (rii or riii) is unusual. furthermore, emergence of quinine resistance during therapy of malaria infections in humans and animals is uncommon. in the current study, exposure of the panama ii strain of p. falciparum in aotus monkeys to subcurative quinine therapy during six serial passages over 6 months resulted in a shift in the quinine responsiveness o ...	1978	415628
[two new cases of autochtonous malaria in the parisian area showing two different modes of contamination].		1978	383308
a study of the role of immunological factors in the pathogenesis of the anaemia of acute malaria.	children with acute plasmodium falciparum malaria and anemia were investigated to see if immunological factors could be implicated in the pathogenesis of their anaemia. direct coombs tests using an anti-whole immunoglobulin antiserum were negative in all 12 children tested but two had positive tests with antisera to c3b and c3d. low plasma levels of c3 and c4 were found but these were not significantly different from values found in a group of children with acute malaria who were not anaemic. se ...	1978	360499
an integrated view of entomological and parasitological observations on falciparum malaria in gambela, western ethiopian lowlands.		1978	360497
observations on malaria in an industrial area of chotonagpur.		1978	383847
[the question of anhaptoglobinemia in immigrants from west africa (author's transl)].	studying the plasmatic level and the phenotype of haptoglobine (hp) in 71 west africans living in france, the authors did not record any case of absence of hp (hpo) and did not see any significant correlation between the hp and the duration of stay in france. they conclude that plasmodium falciparum likely does not play any role in the origin of the hpo peculiarity in west african immigrants.	1978	745527
topical aspects of the epidemiology of malaria.		1978	355188
the biological suppression of malaria: an ecological and nutritional interrelationship of a host and two parasites.	the interrelationship of malaria and severe ascariasis was studied in anjouan children with a previously described syndrome of enlarged parotids, localized forehead edema, heavy infestation with ascaris lumbricoides, and unusual freedom from malaria. after treatment of 37 such children with the ascaricide piperazine, 35 had resolution of parotid enlargement and forehead edema, but 19 developed attacks of malaria. children treated with placebo had neither resolution of clinical findings nor attac ...	1978	354372
acute pulmonary edema in plasmodium falciparum malaria.	this report describes a patient who developed acute pulmonary edema as a complication of plasmodium falciparum malaria. hemodynamic evaluation revealed a pulmonary artery wedge pressure of 3 mm hg and a cardiac index of 4.6 liter per min per m2. the patient exhibited an acute decrease in serum colloid osmotic pressure from 25.1 mm hg to 16.8 mm hg. these findings suggest that pulmonary edema in this patient was the result of altered capillary membrane permeability.	1978	358880
cellular mechanism for the protective effect of haemoglobin s against p. falciparum malaria.		1978	353566
the treatment of malaria.		1978	362573
pharmacokinetics of antimalarials and proposals for dosage regimens.	blood level data for the antimalarials amodiaquine, chloroguanide, chloroquine, pyrimethamine, quinine and sulphadoxine have been retrieved from the literature and pharmacokinetically analyzed. minimum, average and maximum blood level concentrations at steady state in suppressive treatment and peak concentrations in therapeutic treatment were predicted and blood level-time curves simulated. based on the computer-predicted data, changes in dosage regimens are proposed to reduce the fluctuations b ...	1978	359493
continuous in-vitro cultivation of the human malaria parasite.		1978	356695
immunopathology of human malaria.		1978	355197
some recent advances in the cultivation of plasmodium falciparum.		1978	355191
chemoprophylaxis of malaria.		1978	356694
[malaria caused by accidental inoculation. 1 case].	the authors report a case of direct infection of a nurse who had taken blood sample from a young patient suffering from malaria due to plasmodium falciparum. six similar observations have been reported in the literature. in addition, accidental infection has been observed following the use of non sterile syringes. as a result, malaria could be an unexpected consequence of the drug habit.	1978	369732
cerebral malaria. a disseminated vasculomyelinopathy.	neuropathologic examination of 19 fatal cases of cerebral malaria and a review of the literature showed that the epidemiologic, clinical, and pathologic features of this entity suggest consideration of cerebral malaria as a form of disseminated vasculomyelinopathy, a hyperegic reaction of the cns to the antigenic challenge of plasmodium falciparum infection. experimental evidence also substantiates this view the initial event seems to be vasculopathy, with alteration of the endothelial permeabil ...	1978	348169
comments on seroepidemiologic studies.	if the tools for the control of transmission are not available, the application of seroepidemiologic methods, as an exercise in the tropics, just in order to assess the magnitude of the problem of malaria transmission, should be restricted. application of seroepidemiologic methods in connection with control operations seems valuable. they can provide new and basic information. it is very unlikely that in control schemes, the assessment of incidence of fresh parasitemias is better, easier, or mor ...	1978	355205
the spread of chloroquine-resistant falciparum malaria in papua new guinea.	two cases of chloroquine-resistant plasmodium falciparum malaria have been reported from eastern papua new guinea in order to alert the medical profession about the spread of resistant strains throughout that territory.	1978	355814
the duffy blood group and resistance to plasmodium vivax in honduras.	to test the hypothesis that the duffy blood group negative genotype is a factor in resistance to plasmodium vivax, we determined the duffy blood group, the malaria antibodies, and the slide-demonstrated infection rates with p. vivax and p. falciparum of 420 persons living in nueva armenia, honduras. in all, 247 persons were duffy negative. demonstrated infections with p. falciparum were almost equally distributed between duffy-positive (5,8%) and duffy-negative (4.9%) persons. similarly, duffy-p ...	1978	356634
plasmodium falciparum in culture: establishment of additional strains.	the establishment of new strains of plasmodium falciparum in continuous culture is described. one line (fcr-2), isolated from an individual who had traveled extensively through south america, was passed initially through aotus trivirgatus monkeys and then cultured into human erythrocytes using the flow-vial technique. a strain of p. falciparum fmg), shipped by air freight on wet ice from the gambia, was cultured directly from a human infection into continuous culture using the petri dish-candle ...	1978	356635
[5 cases of imported malaria].		1978	358306
the malaria burden and population growth in the solomon islands.	this paper outlines the result of the control of infectious diseases, and more especially malaria, on the growth of populations in the solomon islands since 1931, the year of the first census, to 1976, the year in which the fourth census revealed, that a population explosion had occurred, and was occurring unabated.	1978	358655
malaria and pregnancy.	a review of current literature on the effects of malaria on pregnant women and the foetus is made and its effective control is discussed. the role of placenta as an exchange organ and as the first defence line for foetus is also described. reduced resistance to malaria during pregnancy may be due to immunological and hormonal changes. in malarious areas, the effective control of malaria results in reduced maternal anaemia and in increased birth-weights. prophylaxis, treatment and other antimalar ...	1978	358656
malumfashi endemic diseases research project. ii. malariometry in malumfashi, northern nigeria.	prior to longitudinal studies into the effects of malaria upon the immune response, nutritional status and haematological indices in young children in northern nigeria, the degree of malarial endemicity in the area has been established. field work was carried out in the wet seasons of 1976 and 1977 and the dry season of 1977 (april). seasonal variation in transmission has been demonstrated. age-specific parasite prevalence rates and splenic indices confirm previous studies that this northern par ...	1978	358930
haemostatic defect in non-immune patients with falciparum malaria: no evidence of diffuse intravascular coagulation.	nine non-immune patients with imported falciparum malaria were examined for signs of diffuse intravascular coagulation (dic). although all had thrombocytopenia initially and some later had a decline in plasma fibrinogen concentrations, dic was never detected, even in severely affected patients with coma and kidney damage. none of the patients were given heparin and all recovered without residual symptoms. heparin administration should probably be considered only when clear-cut dic, which possibl ...	1978	359086
relative chloroquine resistance.		1978	359093
intravascular coagulation in falciparum malaria.		1978	359097
malaria transmission by platelet concentrate transfusion.		1978	359848
carl jung.	physicians should be prepared to provide prophylactic medications for travelers to malarious areas and to treat patients with malaria. chloroquine hydrochloride is the suppressive agent of choice for treatment of mild infections due to all species of malaria except for those due to chloroquine-resistant strains of plasmodium falciparum. for treatment of severe infections with p falciparum and for treatment of all infections due to chloroquine-resistant strains of p falciparum quinine is the supp ...	1978	359849
therapy and prophylaxis of malaria.	physicians should be prepared to provide prophylactic medications for travelers to malarious areas and to treat patients with malaria. chloroquine hydrochloride is the suppressive agent of choice for treatment of mild infections due to all species of malaria except for those due to chloroquine-resistant strains of plasmodium falciparum. for treatment of severe infections with p falficparum, quinine is the suppressive agent of choice. chloroquine is also the prophylactic agent of choice for most ...	1978	359850
[epidemiology and clinical aspects of malaria in switzerland].	plasmodium falciparum is the predominant plasmodium species in africa south of the sahara to a proportion of 80% and more. two thirds of all cases of malaria in switzerland are imported from africa. accordingly, malignant malaria is more frequently diagnosed in switzerland than tertian malaria. malignant malaria usually presents atypically, e.g. as acute gastrointestinal disease or as shock. the lethality is high. the majority of swiss travellers are not protected effectively against malaria. a ...	1978	362526
chloroquine resistance produced in vitro in an african strain of human malaria.	after condinous cultivation in the presence of chloroquine, an african strain of the malaria parasite, plasmodium falciparu, acquired resistance to the drug. the resistance was stable and comparable in vitro to that occurring naturally in a strain from southeast asia. this suggests that chloroquine resistance, absent until now in africa, might arise in the future.	1978	351801
falciparum malaria in seamen.	three cases of plasmodium falciparum malaria in seamen, all acquired while working off tropical west africa, and all in patients coming in for treatment at a new orleans hospital during one six-week period, are described in the context of the importance of considering recent travel history for arrival at the correct diagnosis and treatment. two of the three patients whose cases are reported had taken some form of malarial chemoprophylaxis during their voyage.	1978	349186
results of treatment of plasmodium falciparum infection with chloroquine in some parts of tamil nadu.		1978	363614
falciparum malaria with acute pulmonary insufficiency. report of a survived case.		1978	363959
differentiation of gametocytes in microcultures of human blood infected with plasmodium falciparum.	gametocytes differentiated from ring-stage parasites in microcultures of human blood infected with plasmodium falciparum. immature gametocytes could be distinguished morphologically from late asexual trophozoites after approximately 40 h of culture. differentiation into crescentic forms took several days and the incorporation of [3h]-isoleucine by developing gametocytes was demonstrated. about 1% of red cells contained gametocytes at the maxiumum densities attained. differentiation of gametocyte ...	1978	364046
[acute renal insufficiency caused by plasmodium falciparum malaria in the last period of pregnancy (2 cases) (author's transl)].	a report of 2 cases of acute renal insufficiency in african women, 8 months pregnant and suffering of malignant malaria. in both cases labor has been induced by artificial breaking of the membranes and use of oxytocin. one of the children was still-born and the other died 3 days later. delivery has been followed by a resumption of the urinary flow, facilitated by high dosages of furosemide. this diuretic drug when associated with hypoprotidic diet, hypercaloric intravenous infusions of glucose h ...	1978	364241