Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| vaccine production as a unit process. | 1974 | 4373785 | |
| diphtheria carriers and the effect of erythromycin therapy. | one hundred and fourteen corynebacterium diphtheriae, toxigenic, gravis type, pharyngeal carriers were identified during a diphtheria epidemic in elgin, texas. all carriers were treated with erythromycin estolate, 1 g/day in divided doses for 6 days. serial pharyngeal cultures were obtained in order to monitor the bacteriological response. seventy-two carriers had positive cultures immediately prior to the start of therapy, and only these individuals were considered in the analysis of the effect ... | 1974 | 15828187 |
| letter: recognition of diphtheria. | 1975 | 46974 | |
| letter: avirulent corynebacteria. | 1975 | 47127 | |
| letter: recognition of diphtheria. | 1975 | 47573 | |
| non-toxigenic corynebacterium diphtheriae in a boarding school. | a non-toxigenic strain of corynebacterium diphtheriae var. gravis was isolated from 31 boys during an outbreak of sore throats at a boarding school of 15 staff and 134 pupils. despite the non-toxigenicity of the strain involved, conventional isolation procedures were observed and all boys at the school were treated with antibiotics. restrictions on the school were only relaxed when no further carriers were detected. the rationale of such management of an episode involving a non-toxigenic strain ... | 1975 | 48687 |
| letter: recognition of diphtheria. | 1975 | 48850 | |
| [bacteriological studies of butirosin sulfate, a new aminoglycoside antibiotic (author's transl)]. | 1975 | 51941 | |
| quantitative assay of diphtherial toxin and of immunologically cross-reacting proteins by reversed passive hemagglutination. | a reversed passive hemagglutination (rpha) assay for diptherial toxin has been developed. antitoxic antibodies were isolated from commercially available equine diptherial antitoxin by immunoabsorption using highly purified diphtherial toxin covalently linked to sepharose 4b. formalinized, tanned sheep erythrocytes sensitized with the purified antitoxic antibodies are specifically agglutinated by diphtherial toxin but are not agglutinated by extracellular antigens of corynebacterium diptheriae th ... | 1975 | 54339 |
| diphtheria toxin: mode of action and structure. | 1975 | 164179 | |
| the action of vibrio cholerae and corynebacterium diphtheriae neuraminidases on the sendai virus receptor of human erythrocytes. | studies of the sendai virus haemagglutinin receptor on the human erythrocyte surface have confirmed that it involves 2 leads to 3 linked sialic acid. because the primary specificity of vibrio cholerae neuraminidase is for this linkage, it is able to compete with the virus for the receptor, to which it adsorbs strongly at low temperatures. corynebacterium diphtheriae neuraminidase, whose principal specificity is for a sialic acid linkage other than 2 leads to 3, does not easily remove sendai viru ... | 1975 | 168311 |
| [changes in the antibacterial effects of organs and tissues of ornithodoros papillipes birula ticks]. | 1975 | 234572 | |
| the bacteriological ecosystem of the skin of children in an african tropical envirovment (tanzania). | using a standardized method for sampling, the aerobic microbial flora of the skin of ninety-five children in dar es salaam, tanzania, was studied qualitatively and quantitatively. the subjects comprised three groups; group a, thirty-seven normal infants (below the age of 1 year); group b, twenty-nine infants with various bacterial skin lesions; and group c, twenty-nine nursery school children between 4-5 and 7 years. the following observations were made: (i) the quantitative results indicated; ( ... | 1975 | 239739 |
| interaction of toxin of corynebacterium diphtheriae with phagocytes from susceptible and resistant species. | the interaction of the toxin of corynebacterium diphtheriae with leukocytes from sensitive and resistant animal species was examined by determining the ability of toxin to inhibit protein synthesis by several types of phagocytic cell. small amounts of toxin (25 minimal lethal doses) impaired protein synthesis in both polymorphonuclear leukocytes and mononuclear cells from humans and guinea pigs, whereas large amounts (2,000 minimal lethal doses) were required for minimal inhibition of mouse phag ... | 1975 | 804024 |
| letter: clinical diphtheria from nontoxigenic corynebacterium? | 1975 | 804026 | |
| [action of decamethoxin on diphtherial exotoxin]. | the results of the study of the detoxicating effect of decamethoxin on diphtheria toxin are presented. it was noted that decamethoxin in subbacteriostatic concentrations inhibited the process of the toxin production in corynebacteria diphtheriae. the detoxicating effect of the drug was clearly evident when used in a concentration of 10gamma/ml at a 2-hour exposure. decamethoxin in a dose of 0.1 gamma/ml neutralized the effect of the diphtheria toxin on contact for 24 hours. | 1975 | 804292 |
| biologically active components from mycobacterial cell walls. iii. production of experimental allergic encephalomyelitis in guinea-pigs. | the efficacy of various fractions of mycobacterial cell walls in producing experimental ahlergic encephalomyelitis (eae) has been evaluated. bcg (bacillus-calmette-buérin) cell walls were effective in producing eae in all animals at dose levels as low as 40 mug. study of subfractions of these cell walls revealed the following: (1) wax d was active, but required larger doses than bcg cell walls; (2) the chloroform-methanol-soluble (cms) portion of wax d and p3 (a mycolic acid-trehalose ester cont ... | 1975 | 804436 |
| new method for the large-scale preparation of diphtheria toxoid: purification of toxin. | diphtheria toxin of high purity was prepared in batch cultures of 1 to 40 liters by procedures capable of processing 200-liter batches without modification. the procedure incorporates preliminary purification of the growth medium and, after deep fermentation or sulfate culture of corynebacterium diphtheriae, both concentration and partial purification of the toxin by membrane ultrafiltration. final purification is achieved by sephadex g-100 gel filtration. purities of 2,000 to 2,500 flocculation ... | 1975 | 804848 |
| the role of cutaneous diphtheria infections in a diphtheria epidemic. | twenty-four people with diptheria and 48 carriers were found in an isolated, circumscribed, rural area during a one-month period. four patients had cutaneous lesions, which were similar to those of typical impetigo, form which corynebacterium diptheriae was isolated. these cases constituted an epidemiologic focus from which the other cases were infected. ten of 52 classroom contacts of two patients with skin infections harbored c. diphtheriae in the pharynx, while only eight of 132 classroom con ... | 1975 | 805182 |
| letter: diphtheria carriers. | 1975 | 806244 | |
| adjuvant activity of mycobacterial fractions. i. purification and in vivo adjuvant activity of cell wall skeletons of mycobacterium bovis bcg, nocardia asteroides 131 and corynebacterium diphtheriae pw8. | the adjuvant activity of cell wall skeletons (mycolic acid-arabino-galactan-mucopeptide, cws) prepared from the cells of mycobacteria, nocardia and corynebacteria was examined in vivo in mice and guinea pigs. the cell wall skeletons of mycobacterium bovis bcg (bcg-cws), nocardia asteroides 131 and corynebacterium diphtheriae pwc suspended in freund's incomplete adjuvant (fia) as water-in-oil emulsions showed potent adjuvant activity on the formation of circulating antibody and cell-mediated immu ... | 1975 | 807194 |
| skin infections and the epidemiology of diphtheria: acquisition and persistence of c diphtheriae infections. | acquisition and persistence of c. diphtheriae infections of skin lesions and of the respiratory tract were observed in households exposed to c. diphtheriae carriers in a community experiencing a diphtheria outbreak and in households in two communities free of the disease. acquisition of c. diphtheriae was more frequent in epidemic households, apparently due to a greater frequency of respiratory tract acquisition. skin lesion acquisition was constant in both situations. the pattern of persistence ... | 1975 | 808123 |
| evidence for an infectious etiology of rheumatoid arthritis. | 1975 | 808992 | |
| scabies and other skin diseases in pre-school children in ujamaa villages in tanzania. | a survey of skin diseases was carried out in pre-school children in five ujamaa villages in rufiji district and 532 children (5.3% of the total population) were screened. the results showed that scabies was the commonest skin problem affecting 31% of the children. primary pyoderma and fungal infections were relatively less common and accounted for 7.0 and 2.4% respectively. staphylococcus aureus, group a beta haemolytic streptococci and corynebacterium diphteriae were the commonest pathogeneic b ... | 1975 | 810929 |
| bacterial skin infections in preschool and school children in coastal tanzania. | in coastal tanzania, 1,855 preschool and school children were studied for pyoderma (superficial bacterial infections of the skin exclusive of secondarily infected scabies) and for scabies. the predisposing personal, socleoeconomic, and hygienic variables for both conditions were studied also. pyoderma lesions and some secondarily infected scabies were cultured aerobically for bacterial isolates and the predisposing factors were determined by interviews, home visits, and physical examinations. py ... | 1975 | 811175 |
| numerical analysis of the characteristics of corynebacterium diphtheriae strains isolated in victoria from 1962 to 1971. | a study of the incidence of diphtheria in the state of victoria, australia, was carried out. numerical analysis of the characteristics of 264 strains of corynebacterium diphtheriae isolated between 1962 and 1971 placed them into 18 varieties plus six strains which were unique in their combination of reactions to the characteristics examined. during the 10-year period, some varieties appeared intermittently and were recognized by certain defining characteristics but exhibited a gradual change in ... | 1975 | 811707 |
| adjuvant activity of mycobacterial fractions. iii. adjuvant effect of cell wall of mycobacterium bovis bcg on cell-mediated cytotoxicity in mice. | a quantitative assay and characterization of oil-attached cell wall of mycobacterium bovis bcg (bcg-cws) which stimulates cell-mediated immunity of spleen cells to alloantigens in mice were carried out by an in vitro cell-mediated cytotoxicity test using 51cr-labeled target cells. c57bl/6j mice (h-2b) were immunized intraperitoneally with mastocytoma cells (h-2d) with or without oil-attached bcg-cws. the cytotoxicity, comparable to that of spleen cells from mice immunized with mastocytoma cells ... | 1975 | 811834 |
| [pathogenetic aspects of the "healthy" diphtheria bacteria carrier state]. | 1975 | 812302 | |
| [patterns of antimicrobial immunity in carriers of toxigenic diphtheria bacteria]. | it was shown in the passive hemagglutination test (phat) with a type-specific somatic antigen on 147 carriers of toxigenic diphtheria bacilli that the phat titres of 1/80 and over were determined in 64% of bacteria. in the process of carrier state of toxigenic bacteria antimicrobial antibodies were detected in 79% of the children; after the release from the carrier state, the percentage was from 57 to 26, depending on the time lapse after it. among the carriers of nontoxigenic diphtheria bacilli ... | 1975 | 812306 |
| [study of the reasons for a decrease in the inoculability of diphtheria bacteria]. | it was shown that the seeding efficacy of diphtheria bacilli depended not only on the state of the epidemic process, but also on the correct methodical approach to the examination. a combination of the qualitative and epidemiological choice of the groups of population for bacteriological examination with the use of blood tellurite media permitted to increase the efficacy of investigations, with a considerable reduction of the number of analyses. | 1975 | 812307 |
| [enzymatic properties of neuraminidase from corynebacterium diptherial]. | enzymatic properties of neuraminidase isolated from non-toxigenic strain c7 of diphteritic bacteria are studied. the enzyme has the ph optimum 5.5--6.0 in acetate buffer and the temperature optimum 38 degrees c. neuraminidase has the highest substrate affinity to glycoproteins of equine blood serum, the lowest affinity--to 3-n-acetylneuraminosyllactose and ovomucin. the km values was 4.3-10(-4) at optimal conditions under the hydrolysis of 3-n-acetylneuraminosyllactose, vm was 0.05+/-0.02 mum na ... | 1975 | 812557 |
| [antibacterial activity of a lysozyme-like enzyme from staphylococci]. | a lysozyme-like enzyme isolated from the culture broth of staph. aureus 712 presented in its native state a lipoproteid complex. the lytic and antibacterial spectrum of the enzyme was similar to that of the egg albumin enzyme. however, the lipoproteid complex was somewhat superior to the egg albumin complex in its activity against micrococcus lysodeikticus, a number of gramnegative bacteria and staphylococci. out of the organisms studied microccus lysodeikticus, sarcina and bac. subtilis proved ... | 1975 | 813563 |
| [use of the corycin test and of bacteriophage typing for genetic marking of corynebacteria with reference to c. diphtheriae of the gravis type]. | nontoxigenic c. diphtheria, fermenting starch, of convertible phage types abcdfch, abcdfg, abcdf, abcd, abd, acdf, cdf, af and a, and also strains of nonconvertible bacteriophage types i, h and k proved to be noncoricynogenic in the corycine test and weakly sensitive to bacteriocin of the no. 3463 test strain (a study was made of a total of 502 strains). strains (383) isolated from 354 patients and carriers--starch-fermenting and toxigenic to the gravis type--were toxigenic were lysed by a combi ... | 1975 | 814754 |
| [the effect of neuraminidase of c. diphtheriae on the functional capacity of the peritoneal exudate cells of guinea pigs to diphtheria bacilli]. | a study was made of the effect of neuraminidase preparation containing no diphtheria toxin admixtures and hyaluronidase on the phagocytic activity of macrophages. neuraminidase produced a stimulating effect on the cells of the developing macrophage culture. the macrophages treated with the enzyme increased their capacity to digestion of nontoxigenic diphtheria bacilli. | 1975 | 814758 |
| [studies on the frequency of corynebacterium diphtheriae carriers among students of the elementary schools in bari]. | the morbidity of diphtheria reported in bari in 1970 and in 1971 was 17.1 and 19.1 for 100000 inhabitants; in the same years the national average was respectively 1.6 and 1.3. in a epidemiological research carried out in the same period in 1017 school-children of bari not previously selected, 45 carriers of c. diphtheriae (4.42%) were identified. toxigen strains were isolated from 11 carriers (1.08%). the frequency of carriers was higher in the school-children 9-11 years aged (6-04%), lower in t ... | 1975 | 820281 |
| [studies on the diffusion of corynebacterium diphtheriae carriers in a children's community]. | during an epidemiological inquiry in a infantile community it was founded the 22.8% of 83 children was carrier of toxigen c. diphtheriae and two adults on 15 were carriers of non toxigen c. diphtheriae. the isolated species respectively from children and adults were of different phagic type. | 1975 | 820282 |
| [the antibacterial effect of organs and tissues of hyalomma dromedarii, hyalomma anatolicum and ixodes persulcatus ticks]. | 1975 | 815775 | |
| studies on diphtheria in bombay. | 1975 | 815957 | |
| iron and diphtheria toxin production. | 1975 | 815958 | |
| level of redox potential as a possible contributing influence in the pathogenicity of oral anaerobes. | dental plaque anaerobes may be associated with the etiology of periodontal disease. this has created an interest in the potential pathogenicity of oral anaerobes. we compared the metabolic activity of anaerobic corynebacteria (c. parvum, c. anaerobium) and corresponding aerobic species (c. diphtheriae, c. xerosis). the anaerobes exhibited lower levels of rna synthesis, ranging from 5 to 10 fold over the aerobes. we further examined these anaerobes, plus actinomyces naeslundi n16 (isolated from t ... | 1975 | 816253 |
| studies on diphtheria infection in and around delhi (a bacteriological study from faucial and cutaneous lesions). | 1975 | 816969 | |
| [microbiological characteristics and sensitivity to antibiotics of decamethoxin-resistant diphtheric bacilli]. | biological properties and sensitivity of 6 corynebacteria strains to 9 antibiotics were studied in vitro. the rate of the development of resistance to neomycin, levomycetin, decamine and decamethoxin in the diphtheria causative agents was determined. biological properties of the decamethoxin resistant variants of the diphtheria causative agents were investigated: 100 passages on media with increasing amounts of the drug. the rate of the development of resistance to decamethoxin was slower than t ... | 1975 | 817649 |
| mitogenicity of corynebacterium parvum for mouse lymphocytes. | corynebacterium parvum, a powerful in vivo immunostimulant, is shown to stimulate lymphocyte proliferation in vitro. c. parvum is mitogenic for b lymphocytes and does not stimulate t cells. the mitogenicity is dependent on the presence of macrophages. c. diphtheriae and another strain of c. parvum, both of which are devoid of adjuvant, res stimulation, and tumour-inhibiting activities in vivo are nevertheless mitogenic. a lipid-free fraction from c. parvum, which retains in vivo immunostimulator ... | 1975 | 817854 |
| genetic basis of toxin production and pathogenesis in vibrio cholerae: evidence against phage conversion. | the pathogenicity of vibrio cholerae strains "cured" of "kappa-type" phage was not significantly altered relative to that of their "kappa" lysogenic parental strains. unlike corynebacterium diphtheriae, the capacity of v. cholerae to produce exotoxin was not stimulated as a consequence of active phage multiplication. toxin production in cultures in which kappa-type phage multiplication was initiated either by inducing kappa lysogens or by infecting naturally occurring or "cured" kappa-sensitive ... | 1975 | 1090531 |
| production and characterization of exotoxin(s) of shigella dysenteriae type 1. | a semicontinuous fermenter system was developed in which broth culture filtrates of shigella dysenteriae type 1 yielded substantial amounts of exotoxin. biologic activity of the exotoxin was characterized by means of three assays: the rabbit ileal loop for fluid evocation (enterotoxicity), mouse lethality after parenteral injection (neurotoxicity), and hela cell toxicity in vitro (cytotoxicity). although the culture filtrate was highly active, disc electrophoresis revealed that the toxin is a mi ... | 1975 | 1092769 |
| bacterial interference by streptococcus salivarius. | a strain of streptococcus salivarius, recognized in a throat culture because of its inhibition of the growth of a species of corynebacterium, was studied in vitro to determine its antagonistic effects agains various other bacteria. it was found to be inhibitory to anaerobic gram-positive cocci, streptococci belonging to lancefields groups a, c, f, and g, and corynebacterium diphtheriae, c. hofmanii, and c. xerosis. | 1975 | 1155368 |
| immunoadjuvant activities of cell walls and their water-soluble fractions prepared from various gram-positive bacteria. | the cell walls from all 21 species of gram-positive bacteria examined, except lysozyme-susceptible micrococcus lysodeikticus (nctc 2665) and lysozyme-resistant staphylococcus epidermidis (atcc 155), were found to be definitely adjuvant-active in both stimulation of increased serum antibody levels and induction of delayed-type hypersensitivity to ovalbumin when administered to guinea-pigs as water-in-oil emulsions. using various cell wall lytic enzymes, the immunoadjuvant principles were solubili ... | 1975 | 1180872 |
| current status of passive immunity to diphtheria and tetanus in the newborn. | the extent of transplacentally derived immunity to the toxins of corynebacterium diphtheriae and clostridium tetani was assessed by a hemagglutination technique using the cord sera of a group of infants recently born in bronx, new york. protective levels of antitoxin to c. diphtheriae were found in 64% of the infants. tetanus antitoxin was present in sufficient quantity for protection in 38% of the cord sera. while this degree of immunity reepresents an improvement over that achieved 20 years ag ... | 1976 | 1245766 |
| antimicrobial activity of econazole and miconazole in vitro and in experimental candidiasis and aspergillosis. | the antibacterial and antimycotic activity of econazole base, an imidazole derivative, was examined in vitro and in experimental infections of mice. comparative minimal inhibitory concentration (mic) determinations indicate econazole as well as miconazole to be of moderate activity against gram-positive bacteria (mics: 0.78-25mug/ml) and yeasts (mics: 1.56-25 mug/ml). against filamentous fungi, econazole exhibits better in vitro activity than miconazole and - with the exception of rhizopus oryza ... | 1976 | 817875 |
| proceedings: taxonomy of aerobic cutaneous diphtheroids. | 1976 | 819023 | |
| [new fluorescent microscopical technique in diagnostic microbiology (author's transl)]. | the practicability of 4',6-diamidino-2-phenylindole (dapi) in the fluorescent microscopical demonstration of bacterial and other cellular structures for medical diagnostic purposes was investigated. polar bodies in diphtheria bacilli and spores of spore-forming bacteria showed up well. the demonstration of phagocytosed bacteria in urinary sediment and the morphology of human spermatozoa are particularly impressive. noteworthy advantages of dapi are its stability (no bleaching of stained preparat ... | 1976 | 819241 |
| corynebacterium diphtheriae endocarditis. | two patients with corynebacterium diphtheriae endocarditis have been observed in the past ten years. both cases occurred sporadically. in one case toxigenic c. diphtheriae caused endocarditis in an immunized child with congenital heart disease. the second patient developed rapidly progressive valve destruction caused by a nontoxigenic strain of c. diphtheriae. these cases illustrate that c. diphtheriae may produce endocarditis in addition to its previously described diseases spectrum. | 1976 | 820199 |
| characterization and genetic mapping of nontoxinogenic (tox) mutants of corynebacteriophage beta. | seven new nontoxinogenic (tox) mutants of corynebacteriophage beta were isolated. strains of cornyebacterium diphtheriae c 7 lysogenic for these tox mutants of beta were tested for their ability to produce extracellular diphtherial toxin or proteins (crms) that cross-react immunologically with toxin. by using a sensitive reversed passive hemagglutination assay for toxin antigen, three of the tox mutants were phenotypically crm+ and four were crm-. the molecular weights of the crms produced by mu ... | 1976 | 820871 |
| prophage map of converting corynebacteriophage beta. | a prophage map for corynebacteriophage beta consisting of seven markers has been constructed and compared with the vegetative map. the mapping system utilizes heteroimmune double lysogens and capitalizes on the fact that these double lysogens are very unstable and throw off monolysogenic segregants. the prophage map, produced by characterizing the recombinant phage in these monolysogenic segregants, appears to be a cyclic permutation of the vegetative map with the gene for toxin at one end of th ... | 1976 | 820872 |
| isolation and characterization of tox mutants of corynebacteriophage beta. | seventeen nontoxinogenic (tox) mutants of corynebacteriophage beta have been isolated by using a tissue culture screening technique. the mutants fall into four major classes. two of the classes, i and ii, appear to contain missense and nonsense mutants, respectively. however, classes iii and iv have not been previously described. class iii mutants produce two proteins (crms) seriologically related to diphtheria toxin, but efforts to demonstrate the presence of more than one tox gene have been su ... | 1976 | 820873 |
| orientation of the tox gene in the prophage of corynebacteriophage beta. | the orientation of the gene for diphtheria toxin, tox, in the prophage of converting corynebacteriophage beta has been determined. the orientation of tox in prophage and that reported simultaneously by holmes (1976) for vegetative phage are compatible with the hypothesis that beta phage is inserted into the chromosome of its bacterial host by means of a mechanism similar to that described for lambda phage, and that the phage attachment site lies between the tox and imm genes. the position of thr ... | 1976 | 820874 |
| diphtheroid endocarditis. report of nine cases and review of the literature. | diphtheroid endocarditis is a rare disease. a large proportion of the reported cases have occurred in the presence of prosthetic heart valves. nine previously unreported cases of diphtheroid endocarditis are discussed along with 25 others taken from the literature. eight out of the nine new cases occurred in patients with artificial heart valves. a high mortality was associated with infections occurring on prosthetic heart valves. microbiological studies were frequently hampered by poor in vitro ... | 1976 | 822234 |
| [contribution to the problem of circulation of diphtheric corynebacteria in the population of bratislava. i]. | 1976 | 822919 | |
| [contribution to the problem of circulation of diphtheric corynebacteria in the population of bratislava. ii. analysis of incidence of diphteric corynebacteria and results of the study concerning their circulation in selected collective establishments (author's transl)]. | 1976 | 824032 | |
| mitogenic activity of the cell walls of mycobacteria, nocardia, corynebacteria and anaerobic coryneforms. | the mitogenic activity of the cell walls prepared from mycobacterium bovis bcg, nocardia rubra, corynebacterium diphtheriae pw8, and four species of propionibacterium, corynebacterium parvum atcc 11829, propionibacterium acnes c7, propionibacterium granulosum atcc 25564 and propionibacterium avidum atcc 25577, were investigated. these cell walls were active as mitogens on normal spleen cells, anti-o sera-treated spleen cells, macrophage-depleted spleen cells of c57bl/6j mice and cortisone-treate ... | 1976 | 824484 |
| adjuvant activity of bacterial glycolipids. | 1976 | 825676 | |
| [surface structure of corynebacteria]. | 1976 | 827168 | |
| [comparative electron-microscopic study of 8 representatives of the genus corynebacterium grown on solid nutrient medium during the stationary phase of development]. | after 18 hours of growth on selective serum-agar medium c diphtheriae cultures with different toxicogenic activity, and also diphtheroid and hoffmann's baccillus cultures were removed, washed of the remnants of the nutrient medium and fixed under cold conditions by two combined methods (with glutaric aldehyde-osmic acid--uranyl acetate, and potassium permeanganate--uranyl acetate). the preparations were studied in ultrathin sections. it appeared that corynebacteria had during the stationary phas ... | 1976 | 827882 |
| a study of the isolation of corynebacterium diphtheria from clinical cases of diphtheria. | throat swabs from 1000 clinical cases of diphtheria were studied for isolation of c. diphtheria; only 21.4% were found to be positive. most of the cases were between 1 to 4 years of age followed by 5 to 8 years. no cases were found below 8 months of age. the throat swabs taken from another 22 clinical diphtheria patients were immediately cultured at patients bed side and 63.6% were found to be positive for c. diphtheria. time between the collection and plating the specimen was considered to be o ... | 1976 | 828854 |
| a comparative study of bacteriologically proved and clinically diagnosed (culture negative) cases of diphtheria. | 1976 | 828918 | |
| [biosynthesis and function of diphtheria toxin and its related proteins (author's transl)]. | 1976 | 829169 | |
| bacterial flora of the healthy skin in children. | the normal bacterial flora of the skin of 100 healthy children was studied in a paediatric practice with regard to the germ spectrum and the resistance constellation, by means of abrasion skin samples taken from the upper part of the back. staphylococcus albus was by far the most predominant bacteria, followed by sarcina bacteria and corynebacteria. the high degree of pervasion of this physiological cutaneous flora with antibiotic-resistant strains increases the suspicion that in the case of flo ... | 1976 | 829225 |
| isolation and partial characterization of a corynebacteriophage beta, tox operator constitutive-like mutant lysogen of corynebacterium diphtheriae. | we have isolated and partially characterized a beta-phage mutant lysogen of corynebacterium diphtheriae, c7(betatoxct1+), which is partially insensitive to iron inhibition of diphtheria toxin production. tox expression by c7(betatoxct1+) was found to be partially constitutive. in the presence of concentrations of iron that almost completely inhibit the expression of diphtheria toxin by the wild type, c7(beta), the level of toxin production by c7(betatoxct1+) was found to be at least 25 times tha ... | 1976 | 815566 |
| bacteria in hip surgery. a study of routine aerobic and anaerobic cultivation from skin and closed suction wound drains. | one hundred and seven patients with closed suction wound drains after hip surgery were investigated with regard to bacteria in the drain. in one-third of the cases bacterial contamination of the wound was found. in more than half the total number of cases the bacteria in the wound were not identical with those found on the skin, either pre- or post-operatively. anaerobe bacteria occurred only in one case. penicillin administration considerably reduced the frequency of positive cultures. these fi ... | 1976 | 181944 |
| fulminant diphtheritic mitral valve endocarditis. | fulminant endocarditis affecting the mitral valve in an 11-year-old boy was caused by a nontoxogenic strain of corynebacterium diphtheriae. | 1976 | 133640 |
| [use of fermented and purified diphtheria antitoxin for determination of pathogenicity of corynebacterium diphtheriae]. | 1976 | 61328 | |
| [minor diphtheria epidemic in a cologne children's home (author's transl)]. | between may and july 1972, 12 children aged from 7 to 14 were admitted to the cologne university children's hospital suspected of having diphtheria. in 10 cases the tonsils or pharyngeal cavity were affected. one case of wound diphtheria and one of nasal diphtheria were observed. the clinical suspicion was confirmed in 8 of 12 cases by detection of the pathogen coryne-bacterium diphtheroides mitis. 11 patients were discharged from the hospital after being treated for between 2 to 6 weeks, but 5 ... | 1976 | 64924 |
| significance of microorganisms found in throat swabs (author's transl). | 1976 | 3776 | |
| the detection of toxin production by corynebacterium diphtheriae in diagnostic laboratories. | in vitro tests for assessing the toxigenicity of strains of c. diphtheriae using the original agar plate precipitin method of elek are unreliable. at high concentrations of antitoxin (500-1000 u/ml) multiple non-specific precipitin lines occur making interpretation difficult. increased specificity was obtained by diluting the antitoxin but this in turn caused a delay in the appearance of toxin-antitoxin lines. also, the failure of lines to appear on media enriched with unsuitable serum may lead ... | 1976 | 9614 |
| identification of producer and biological activities of new antibiotics, mimosamycin and chlorocarcins. | a strain of streptomyces, no. 314 identified as a streptomyces lavendulae produced under a novel condition of culture, four new antibiotics, mimosamycin and chlorocarcins a, b, and c. among the components of chlorocarcin complex, chlorocarcin a was found to be most biologically active. this antibiotic inhibited the growth of staphylococcus aureus fda 209p and corynebacterium diphtheriae at the concentrations of 0.1 and 0.003 mcg/ml, respectively. chlorocarcin a also exhibited antitumor activity ... | 1976 | 931810 |
| a diphtheria outbreak in dade county, florida. | during a 16-week period in late 1969, 11 cases of diphtheria (three fatal) were reported from miami, dade county, florida. for each of ten previous years, two cases at most had been reported. all patients resided in a predominantly black, low socioeconomic community within the 7-square-mile model city area. nine patients had positive cultures for toxigenic corynebacterium diphtheriae, mitis strain. none of the 11 patients or 22 culture-positive household contacts had been vaccinated against diph ... | 1976 | 935909 |
| the effect of corynebacterium parvum on the proliferation of monocyte precursors in the bone marrow of mice. | the anti-tumour activity of c. parvum is thought to be mediated via the monocyte/macrophage system (scott, 1974). these cells originate from rapidly dividing precursors in the bone marrow and it might be at this level that c. parvum exerts its action. to test this hypothesis bone marrow t0 swiss mice has been cultured according to the method of bradley and metcalf (1966), which gives an index of the number of proliferating macrophage precursor cells at the time of sacrifice. experiments were set ... | 1977 | 415919 |
| pathogenesis of diphtheria carrier state from the immunological point of view. | results of a comparative investigation of diphtheria antitoxin and type-specific antibacterial antibodes in 264 carriers of diphtherial bacteria, 41 diphtheria patients and 263 non-infected subjects are presented. a high level of antitoxin did not prevent the development of toxigenic-strain carrier state. a basically similar immunological antibacterial response was observed in patients with manifest forms of diphtheria and in carriers of toxigenic strains; such a response could not as yet be det ... | 1977 | 417135 |
| diphtheria toxin. | 1977 | 20040 | |
| response of cultured mammalian cells to the exotoxins of pseudomonas aeruginosa and corynebacterium diphtheriae: differential cytotoxicity. | the sensitivities of 21 mammalian cell lines to the exotoxins of pseudomonas aeruginosa and corynebacterium diphtheriae were measured. each line exhibited 1-4 log differences in sensitivities to the two toxins. no species-specific sensitivities were noted for pseudomonas exotoxin while diphtheria exotoxin was most potent in cells of monkey origin, followed by human and hamster cells. rat- and mouse-derived cell lines were very insensitive to diphtheria exotoxin. the rates of cellular intoxicatio ... | 1977 | 65205 |
| [adsorption of the antigen-reactive cells on the membrane reinforced immunosorbent]. | 1977 | 72857 | |
| differential chemical protection of mammalian cells from the exotoxins of corynebacterium diphtheriae and pseudomonas aeruginosa. | many drugs or chemicals had markedly different effects on the cytotoxicity induced by pseudomonas aeruginosa exotoxin a (pe) or corynebacterium diphtheriae exotoxin (de). the glycolytic inhibitor naf protected cells from de but potentiated the cytotoxicity of pe. another energy inhibitor, salicylic acid, also protected cells from de but had no effect with pe. colchicine and colcemid did not affect the cytotoxicity of either toxin. cytochalasin b exhibited a modest protection from de but no effec ... | 1977 | 141424 |
| [interrelationship between toxigenic and non-toxigenic diphtheria microbes in the epidemic process]. | a study of the circulation of toxigenic and nontoxigenic diphtheria bacilli was carried out in several carrier state foci under conditions of a natural course of the epidemic process. there were 2623 persons under observation. a total of 32158 analyses were carried out, and 2271 strains were isolated and studied. no formation of the toxigenic variants of diphtheria bacillus as a result of phage conversion was revealed in the foci of carrier state despite the wide spread in them of nontoxigenic l ... | 1977 | 143172 |
| [research on anti-diphtheria immunization in the city of bucharest]. | biological, sero-epidemiological and bacteriological investigations, carried out in the town of bucharest for evaluating the present diphtheria vaccination programme showed: -- high anatoxin titers, exceeding the titer considered as protective, in the vaccinates ; -- a concentration of the level of the titers of 1--4 au/ml, in over 62% of the subjects, which means that the protective titer was exceeded 33 to lucru: -- negative schick reaction, in the mean 95.06%, in the subjects examined during ... | 1977 | 143711 |
| antibody responses in normal infants and in infants receiving chemotherapy for congenital neuroblastoma. | three infants with congenital neuroblastoma received a primary series of diptheria-pertassis-tetanus (dpt) immunizations during and after courses of chemotherapy with immunosuppressive medications. serum igg, iga and igm levels and antidiphthria and antitetanus antibody responses were measured and compared with those of normal infants of similar age. protective levels of antibody were achieved by the study patients as well as by the control group. these results support the view that children wit ... | 1977 | 198094 |
| prosthetic valve endocarditis by opportunistic pathogens. | the incidence of endocarditis produced by the so-called "opportunists" as a complication of prosthetic valve surgery is progressively increasing in frequency and gradually transforming the clinical picture habitually associated with this disease. we report six cases of endocarditis produced by opportunistic microorganisms (two cases by candida, and the remaining by serratia, actinobacillus, acinetobacter calcoaceticus, and bacteroides fragilis, and by corynebacterium diphtheriae) in four male an ... | 1977 | 319774 |
| fatty and mycolic acid composition of bacterionema matruchotii and related organisms. | whole-organism methoanolysates of bacterionemae contained mycolic acids in addition to other long-chain fatty acids. these mycolic acids were similar in general structure and overall size to those found in strains of corynebacterium diphtheriae and corynebacterium xerosis. the long-chain fatty acids of bacterionemae, mainly straight-chain saturated and unsaturated acids, were similar to those of certain coryneform bacteria including c. diphtheriae. on the basis of these lipid data, and results o ... | 1977 | 401865 |
| serum effects on the response of mammalian cells to the exotoxins of pseudomonas aeruginosa and corynebacterium diphtheriae. | the response of mammalian cells to pseudomonas and diphtheria exotoxins was studied. a method was developed whereby the sensitivity of cells to these two toxins could be quantitated. the method is versatile and can be used to study the effects of toxins on many cellular metabolic or transport processes. the type of serum used in the culture medium significantly influenced the response of cells to the toxins. calf, horse, and human sera protected cells while fetal calf serum did not. precipitatio ... | 1977 | 402176 |
| [diphtheria epidemic in eastern switzerland in 1974]. | a diphtheria epidemic in the eastern part of switzerland in 1974 and the measures which were taken for its management and eradication are described. in particular it is pointed out that at present diphtheria displays atypical clinical symptoms in europe, a fact that renders the diagnosis very difficult in many cases. therefore, it is important to perform a throat swab in every patient with suspected diphtheria; it is also necessary to explicitly require a search for c. diphtheriae. the early rec ... | 1977 | 403601 |
| enumeration and identification of human leukemic lymphocytes by their natural binding of bacteria. | the recently described property of bacteria to bind to human lymphocytes was used to distinguish between normal and chronic leukemic lymphocyte (cll) populations. strains of the following bacteria were used in this study: arizona hinshawii, escherichia coli strains 1 and 2, bacillus globigii, brucella melitensis, corynebacterium diphtheriae strains 1 and 2, corynebacterium xerosis, sarcina lutea, staphylococcus aureus, and staphylococcus epidermidis. for identification of immunoglobulin-bearing ... | 1977 | 404035 |
| [diphtheria]. | 1977 | 404227 | |
| mutations of corynephage beta that affect the yield of diphtheria toxin. | 1977 | 404756 | |
| [molecular weight of bacterial toxins]. | 1977 | 404803 | |
| [role of oxygen in controlling the process of c. diphtheriae cultivation]. | 1977 | 404809 | |
| differentiation of streptococci from diphtheroids. | 1977 | 405070 | |
| identification of five human lymphocyte subpopulations by their differential binding of various strains of bacteria. | 1977 | 405106 | |
| studies on cutaneous diphtheria in and around delhi. | 1977 | 405317 | |
| diphtheroid osteomyelitis. | isolates of either corynebacterium diphtheriae or propionibacterium acnes from osteomyelitis are not necessarily contaminants, as shown by the cases of three patients who had bone and joint infections in which these organisms were pathogenic (one in pure culture and two in mixed cultures). previous operation or other factors that compromise host resistance create the setting for these opportunistic organisms. penicillin with or without streptomycin is the treatment of choice, but if penicillin o ... | 1977 | 405396 |
| [effectiveness of a hemolyzed preparation for isolation of pure cultures of diphtheria bacilli]. | 1977 | 405555 | |
| [relationship between the culture medium and the fatty acid composition of diphtheria and non-pathogenic corynebacteria]. | the gasochromatic method was applied to the study of the cellular fatty acids composition in diphtheria and nonpathogenic corynebacteria (diphtheroids and psendo diptheria bacillus). marked differences in the content of unsaturated fatty acids were revealed in them. thus, palmito leic acid served the preponderant unsaturated fatty acid in corynebacteria diphtheriae, and unsaturated fatty acids with 18 carbon atoms (octadeconoic and linoleic)--in nonpathogenic corynebacteria. the mentioned change ... | 1977 | 405825 |