Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| in vitro susceptibility of helicobacter pylori to nitecapone. | 1992 | 1597212 | |
| helicobacter pylori lipopolysaccharide stimulates gastric mucosal pepsinogen secretion. | the effect of helicobacter pylori lipopolysaccharide on guinea pig gastric mucosal pepsinogen secretion has been examined using an ussing chamber technique. luminal addition of h. pylori lipopolysaccharide resulted in a fifty-fold stimulation of pepsinogen secretion compared to a twelve-fold increase with e. coli lipopolysaccharide. electron microscopy showed marked degranulation of zymogen granules but no evidence of chief cell disruption. | 1992 | 1600038 |
| sucralfate diminishes basal acid output without affecting gastrin, h. pylori or gastritis in duodenal ulcer patients. | twelve patients with active duodenal ulcer disease and helicobacter pylori infection were treated with 1 g sucralfate q.d.s. for 1 month. ulcers healed in 8 of the 12 patients without an alteration in the h. pylori-associated antral gastritis. sucralfate produced a significant fall in basal acid output in all the patients, from a median of 4.8 (range 2.1-12.1) to 1.6 (0.4-8) mmol/h, p less than 0.01, whereas peak acid output was unchanged from 41 (21-59) before to 38 (24-55) mmol/h after treatme ... | 1992 | 1600044 |
| review article: the treatment of helicobacter pylori infection. | the discovery of helicobacter pylori has stimulated great interest in its role in gastritis, non-ulcer dyspepsia and peptic ulceration. treatment regimens to eradicate this organism from gastric mucosa have also received considerable attention. current recommendations limit the use of triple drug combinations only to specific patient groups. | 1992 | 1600047 |
| does a previous course of tripotassium dicitrato bismuthate affect the subsequent chances of successful helicobacter pylori eradication? | we have performed a retrospective study of 103 patients with either peptic ulcer or non-ulcer dyspepsia, infected with metronidazole-sensitive strains of helicobacter pylori (h. pylori), who were treated with a combination of tripotassium dicitrato bismuthate and metronidazole for a period of at least two weeks. dual therapy with tripotassium dicitrato bismuthate plus metronidazole showed similarly high eradication rates (greater than or equal to 80%) of h. pylori from patients irrespective of a ... | 1992 | 1600049 |
| short report: twenty-four-hour hyperpepsinogenaemia in helicobacter pylori-positive subjects is abolished by eradication of the infection. | twenty-four-hour plasma pepsinogen i and ii concentrations were determined in 8 healthy subjects with antibody to helicobacter pylori, before and after treatment with tripotassium dicitrato bismuthate, amoxycillin and metronidazole, therapy was successful in the 5 subjects with active h. pylori infection. in these subjects, median integrated 24-h plasma pepsinogen i and ii concentrations significantly decreased from 2288 and 357 micrograms.h/l before treatment, respectively, to 1811 and 171 micr ... | 1992 | 1600055 |
| detection of helicobacter pylori-like organisms in the stomach of some food-source animals using a monoclonal antibody. | to investigate a possible animal reservoir of helicobacter pylori, 15 pigs, 15 rabbits and 5 cows slaughtered for consumption were studied. raised serum igg levels were found in 93% of the pigs and 87% of the rabbits, but levels were normal in the cattle. in the controlled testings three of 22 humans had elevated igg to h pylori and in all three h pylori was detected by the use of monoclonal antibody. helicobacter pylori were identified in gastric brushings by a monoclonal antibody in 8 out of 1 ... | 1992 | 1600192 |
| seroepidemiology of helicobacter pylori infection in vegans and meat-eaters. | an enzyme-linked immunosorbent assay has been used to diagnose serologically the prevalence of helicobacter pylori infection in asian life-long vegans. there was no difference in the seropositivity between these individuals and a group of age- and sex-matched asian meat-eaters, indicating the meat consumption is not a risk factor for h. pylori infection. however, both asian groups had a higher prevalence of infection than age- and sex-matched caucasian meat-eaters. additionally, the asian indivi ... | 1992 | 1601079 |
| adherence of helicobacter pylori to hep-2 cells. | the adherence of 25 strains of helicobacter pylori was evaluated in hep-2 cells. these bacterial isolates, obtained from chilean patients with gastric disorders, were also tested for haemagglutination of human red blood cells. adherence of hep-2 cells was expressed as a common property of all strains, irrespective of whether the cultures were grown on semi-solid or in liquid media. previous reports that haemagglutinating activity was present in cells grown only on semi-solid media were confirmed ... | 1992 | 1602147 |
| helicobacter pyrlori in malawi, central africa. | a total of 160 adult malawians with epigastric pain for longer than 2 weeks was investigated by endoscopy and serologically for evidence of infection with helicobacter pylori. the organism was demonstrated histologically and/or by culture in 141 (88%) patients. with histological means and/or culture as the 'gold standard', the histological technique was 100% sensitive while culture was only 81% sensitive. all isolates tested were sensitive to amoxycillin and tetracycline; 74% were resistant to m ... | 1992 | 1602148 |
| helicobacter pylori and non-ulcer dyspepsia in zambia. | 1992 | 1604727 | |
| [is stomach cancer an infectious disease?]. | 1992 | 1604913 | |
| [evaluation of two commercial kits for detection of helicobacter pylori specific antibodies in patients undergoing gastroscopy. a seroprevalence study in an asymptomatic population]. | we evaluate two different commercially available kits for detecting specific antibodies against helicobacter pylori in a group of 48 patients with gastrointestinal symptoms that underwent an endoscopic procedure. we also study the seroprevalence of anti-h. pylori antibodies in asimptomatic individuals from our area. | 1992 | 1606220 |
| is helicobacter pylori the cause of dyspepsia? | to determine the association between infection with helicobacter pylori and dyspepsia. | 1992 | 1606428 |
| symptoms, gastritis, and helicobacter pylori in patients referred for endoscopy. | acute helicobacter pylori infection is associated with dyspeptic symptoms but chronic infection has not clearly been shown to cause symptoms. to define further the role of h. pylori infection and gastritis in dyspepsia, we interviewed all patients about to undergo upper endoscopy, recorded the primary indication for endoscopy, noted the endoscopic findings, and obtained antral biopsies. among non-ulcer patients there was a strong correlation of acute gastritis with h. pylori. gastritis and h. py ... | 1992 | 1607089 |
| pyloric adenocarcinoma in a ferret. | pyloric adenocarcinoma was diagnosed in a ferret with clinical signs of gastric distention. the development of this tumor may be related to helicobacter mustelae infection in the gastric mucosa of ferrets. pyloric adenocarcinoma has only recently been reported in ferrets and should be considered as a differential diagnosis for gastric distention in this species. | 1992 | 1607319 |
| epidemiology of helicobacter pylori in southern china: identification of early childhood as the critical period for acquisition. | a large cross-sectional study to investigate the prevalence and possible modes of transmission of helicobacter pylori was done in southern china. serum samples (1727) were collected from guangzhou city and three rural areas of guangdong province, and the prevalence of h. pylori infection was determined using an elisa. each subject completed a questionnaire. the overall prevalence of h. pylori infection was 44.2%; a significantly higher prevalence was found in guangzhou (52.4%) than in the rural ... | 1992 | 1607687 |
| [studying the role of helicobacter pylori infection in recurrent abdominal pain in children]. | the authors studied the role of helicobacter pylori at recurrent abdominal pain in childhood. helicobacter pylori infection hasn't been found at the 42 examined children. the endoscopy showed esophagitis in 34 cases. the quick urease test, the histological examination, and the bacterial culture are proposed to carry out in ulcus duodeni, gastritis typ. b ulcus ventriculi and not necessary to carry out if the endoscopy shows only esophagitis--emphasize the authors. | 1992 | 1608607 |
| helicobacter colonization and histopathological profile of chronic gastritis in patients with or without dyspepsia, mucosal erosion and peptic ulcer: a morphological approach to the study of ulcerogenesis in man. | helicobacter pylori colonization and the incidence, severity, activity and topography of gastritis were investigated systematically in antrum and corpus mucosal biopsies of 1177 subjects undergoing endoscopy in the absence of gastric complaints (asymptomatic, 49) or for non-ulcer dyspepsia (nud; 631 patients, 72 of whom had gastric and/or duodenal erosions), active gastric ulcer (gu, 76 patients), active duodenal ulcer (du, 138 patients), and healed gastric (hgu, 39 cases) or duodenal ulcer (hdu ... | 1992 | 1609509 |
| helicobacter pylori and peptic ulcer disease. | 1992 | 1610319 | |
| taxonomy of campylobacter, arcobacter, and helicobacter: a review. | 1992 | 1611203 | |
| 'gastrospirillum hominis', another gastric spiral bacterium. | 'gastrospirillum hominis' is a 'new' tightly coiled gram-negative bacterium carrying bundles of sheathed polar flagella. it has been rather infrequently detected in antral and, even more rarely, in fundic mucosa samples removed at endoscopy from patients investigated for helicobacter pylori colonization. until now, it has remained noncultivable but has successfully been maintained in laboratory mice. its identity with similar bacteria found in the stomachs of cats, dogs, monkeys, pigs, and other ... | 1992 | 1611710 |
| [helicobacter pylori: from harmless commensal to clinically significant disease factor]. | 1992 | 1611970 | |
| the importance of determining both urea and ammonium levels in gastric juice for rapid diagnosis of helicobacter pylori infection. | 1992 | 1612043 | |
| helicobacter pylori and non-ulcer dyspepsia. | 1992 | 1612344 | |
| diagnostic efficiency of an ultra-rapid endoscopy room test for helicobacter pylori. | 1992 | 1612370 | |
| subtypes of intestinal metaplasia and helicobacter pylori. | to determine whether there is a relationship between the presence of h pylori and the various subtypes of intestinal metaplasia in the gastric antrum, 2274 antral gastroscopic biopsies from 533 patients were examined. h pylori was found in 289 patients. intestinal metaplasia in general was found in 135 patients. type i intestinal metaplasia was found in 133 patients (98.5%), type ii in 106 patients (78.5%) and type iii in 21 patients (15.6%). ninety eight of these 135 patients (72.6%) were h pyl ... | 1992 | 1612473 |
| suppression of helicobacter pylori reduces gastrin releasing peptide stimulated gastrin release in duodenal ulcer patients. | helicobacter pylori increases gastrin release in duodenal ulcer patients. this may be through disruption or changes in the mucus layer affecting the access of luminal stimulants to gastrin releasing cells. the effect of suppressing h pylori on gastrin release stimulated by a non-luminal stimulus, gastrin releasing peptide (grp), was examined. eleven patients with active duodenal ulcer disease and colonised with h pylori received an intravenous infusion of grp (2.9 pmol/kg/minute for 30 minutes) ... | 1992 | 1612474 |
| ecology of helicobacter pylori in peru: infection rates in coastal, high altitude, and jungle communities. the gastrointestinal physiology working group of the cayetano heredia and the johns hopkins university. | we have examined endoscopic clinic patients in three widely different geographic regions of peru (the coast, the sierra of the andes mountains, and the amazon jungle) for the presence of helicobacter pylori infection associated with active gastritis. the overall rates of infection were high (80% or greater) in all three zones and rates for men were approximately 10% higher than for women in the same zone. men and women in the sierra and jungle areas had significantly higher rates of infection th ... | 1992 | 1612475 |
| purification of recombinant helicobacter pylori urease apoenzyme encoded by urea and ureb. | helicobacter pylori, a gram-negative, microaerophilic, spiral-shaped bacterium, is an etiologic agent of human gastritis and peptic ulceration and is highly restricted to the gastric mucosa of humans. urease, synthesized at up to 6% of the soluble cell protein, hydrolyzes urea, thereby releasing ammonia, which may neutralize acid, allowing survival of the bacterium and initial colonization of the gastric mucosa. the urease protein is encoded by two subunit genes, urea and ureb; however, accessor ... | 1992 | 1612735 |
| an ultrastructural study of helicobacter mustelae and evidence of a specific association with gastric mucosa. | the ultrastructure of helicobacter mustelae, a natural inhabitant of the ferret stomach, has been studied and compared with the human gastroduodenal pathogen h. pylori. h. mustelae is a short, slightly curved rod, 2 microns x 0.5 micron, with four or more sheathed flagella. the most common flagellar configuration is a single flagellum at one terminus, bipolar arrangement at the other end and a lateral flagellum. dense inclusion bodies were observed below the flagellar insertion sites. it is sugg ... | 1992 | 1613782 |
| [causes of functional dyspepsia]. | 1992 | 1618112 | |
| hypertrophic gastropathy with transient sessile polyps. | we report an 8-year-old boy with hypertrophic gastropathy (hg) associated with duodenal giardia lamblia infestation. the follow-up was complicated by the development of gastric polyps at the site of previous biopsies that spontaneously disappeared within 15 months. despite the histological similarity, the different course between ménétrier's disease (md) in adults (chronic, with frequent development of sessile or pedunculate polyps) and hg (uncomplicated and usually spontaneously resolving) sugg ... | 1992 | 1619539 |
| helicobacter, helicobacter everywhere, and not a drop to drink! | 1992 | 1619541 | |
| protein-losing enteropathy and helicobacter pylori. | 1992 | 1619544 | |
| [peptic acid disease associated with helicobacter pylori in children. report of a case]. | we studied a child with peptic acid disease which was associated with h. pylori. the identification of h. pylori was done by biopsy and for antibody test. clinical improvement was observed only with the use of amoxocilin and bismuth subsalycilate. | 1992 | 1621037 |
| peptic ulcer disease. | peptic ulcer disease affects between 5 percent and 10 percent of americans during their lifetime. there are a variety of predisposing factors, including nonsteroidal anti-inflammatory drug (nsaid) use, helicobacter pylori infection, tobacco use and, possibly, certain dietary practices. while h2-receptor antagonists remain the mainstay of therapy, the selection of an antiulcer drug should be individualized. famotidine is preferred in persons who use alcohol, sucralfate may be preferred for mainte ... | 1992 | 1621633 |
| [development of genetic and molecular approaches for the diagnosis and the study of the pathogenic power of helicobacter pylori, agent of inflammatory gastric diseases]. | helicobacter pylori (h. pylori) is a small gram negative bacillus, recently discovered, found in the stomach of patients with active chronic gastritis and duodenal ulcers. production of a potent urease has been described as a trait common to all h. pylori so far isolated. to clarify the role of urease in the pathogenic process, as well as to engineer genetic tools useful for the diagnosis of h. pylori, we cloned the genes responsible for urease activity. a genomic library was constructed in esch ... | 1992 | 1622109 |
| chemotactic activity of helicobacter pylori sonicate for human polymorphonuclear leucocytes and monocytes. | the immunopathology of helicobacter pylori associated active chronic gastritis, which is characterised by predominance of polymorphonuclear leucocyte infiltration, is largely unknown. to evaluate the role of bacterial components as inflammatory mediators ultracentrifuged sonicated preparations were made of clinical isolates of helicobacter pylori. the crude sonicates were shown to exhibit chemotactic activity for human polymorphonuclear leucocytes and blood monocytes in a concentration dependent ... | 1992 | 1624151 |
| optimal survival of helicobacter pylori under various transport conditions. | the ability of clinical isolates and type strains of helicobacter pylori to survive in stuart transport medium, isotonic saline solution, and urea-containing isotonic saline was evaluated. the influences of temperature (4, 10, 15, 20, and 30 degrees c) and holding time (6 to 48 h) and the effect of exposure to air on survival were also studied. the recovery rate of h. pylori was highest from stuart transport medium in comparison with the recoveries from the other transport media tested. we found ... | 1992 | 1624562 |
| expression of hla-dr antigen in different histological types of gastric polyp. | to study the expression of hla-dr antigen in the different histological types of gastric polyps. | 1992 | 1624598 |
| [helicobacter pylori colonization of the gastric remnant following partial resection]. | colonization by helicobacter pylori (hp) in 53 patients after remote gastric surgery and roux-en-y anastomosis was investigated using a rapid urease test (cu-test) and histology (h&e and giemsa stain). the ph-value of gastric juice was measured. hp infection of the gastric remnant was found in 56% of 43 patients after partial resection and in no case after total gastric resection. hp-positive and hp-negative patients were comparable in age, sex distribution, indication and technique of gastric o ... | 1992 | 1626250 |
| immunoglobulin g antibodies to helicobacter pylori in patients with dyspeptic symptoms investigated by the western immunoblot technique. | helicobacter pylori is a gram-negative, curved, rod-shaped bacterium known to cause gastritis and to be an important factor in the pathogenesis of peptic ulcers. serological testing has recently been proposed as an aid in diagnosis of h. pylori infections. in this study, we used the western immunoblot technique to evaluate the possibility of using one or more of the antigens from h. pylori for this purpose. thirteen major bands and about 30 minor bands could be identified by western blotting whe ... | 1992 | 1629330 |
| helicobacter pylori has an ulcerogenic action in the ischemic stomach of rats. | helicobacter pylori (h. pylori) is now accepted as an important cause of chronic active gastritis. there also seems to be an association between the colonization of h. pylori in the gastric mucosa and peptic ulceration. however, it has not demonstrated that the instillation of h. pylori into the stomach produces the ulcerative gastric lesions in animals or humans. we carried out an experiment to study whether or not h. pylori has an ulcerogenic action in the ischemic stomach of rats, using an ex ... | 1992 | 1629566 |
| helicobacter pylori infection in dialyzed patients: bismuth therapy and pharmacokinetics. | 1992 | 1630551 | |
| [stomach ulcer and helicobacter pylori]. | 1992 | 1632003 | |
| [helicobacter pylori]. | helicobacter pylori (hp) are gram-negative spiral bacteria which occur in the human stomach. the bacteria were cultured in vitro for the first time in 1983. it is suspected that the bacteria may cause chronic gastritis of type b and may also be a contributory cause of chronic ulceration and cancer of the stomach. the bacteria are accompanied by characteristic inflammatory changes in the gastric mucosa. the significance for gastritis, chronic ulceration, non-ulcer dyspepsia and carcinoma of the s ... | 1992 | 1632004 |
| ebrotidine effect on the proteolytic and lipolytic activities of helicobacter pylori. | 1. the effect of ebrotidine, a new antiulcer agent, on the activity of mucus degrading of protease and lipase enzymes elaborated by helicobacter pylori was investigated. 2. in the absence of ebrotidine, the h. pylori protease caused extensive degradation of gastric mucus protein, while free fatty acids, glycerol mono-oleate and lysophosphatidylcholine were produced by the action of h. pylori lipase and phospholipase a enzymes. 3. introduction of ebrotidine to the incubation system led to the red ... | 1992 | 1639232 |
| eicosanoid synthesis and helicobacter pylori associated gastritis: increase in leukotriene c4 generation associated with h. pylori colonization. | the importance of pro-inflammatory leukotriene c4 in helicobacter pylori (h. pylori) associated gastritis in man is unknown. fresh gastric biopsy specimens from 28 dyspeptic patients were obtained: 10 showed normal antral histology with no evidence of h. pylori, the remaining 18 patients exhibited histological gastritis and were h. pylori positive as assessed by histology, culture and urease test. twelve of these 18 patients received 240 mg twice daily colloidal bismuth subcitrate for four weeks ... | 1992 | 1641505 |
| serodiagnosis of helicobacter pylori-associated gastritis with a monoclonal antibody competitive enzyme-linked immunosorbent assay. | forty-nine monoclonal antibodies against helicobacter pylori were screened to investigate their capacity to be used in enzyme-linked immunosorbent assay (elisa) competitive systems for the serodiagnosis of helicobacter pylori infection. on the basis of the inhibition pattern showed by the sera of five infected patients, the antibodies were subdivided into five groups. the immunoblotting analysis showed that the antibodies recognized a total of nine different antigenic determinants. in a study of ... | 1992 | 1641587 |
| [helicobacter pylori infections in children]. | in our patient population with chronic aspecific abdominal complaints helicobacter pylori gastritis is no rarity. this entity has been diagnosed in 10 children out of 48 (mean age: 8 years 11 months) who underwent an endoscopy of the upper gastrointestinal tract. after treatment with amoxicillin and colloidal bismuth subcitrate during a period of 2 weeks the complaints disappeared and an eradication was obtained in 7. histology of the antral mucosa demonstrated a type b chronic active gastritis ... | 1992 | 1641843 |
| helicobacter pylori infection in children. a clinical overview. | 1992 | 1643767 | |
| non-immunological defence mechanisms of the gut. | non-immunological defence mechanisms represent an important line of intestinal defence in addition to humoral and cellular immunity. this review summarises the evidence for the role of the non-immunological defence system. protective factors that have been amply documented are gastric juice, intestinal motility, and intestinal flora. components of pancreatic juice, lysozyme, and epithelial cell turnover may also be involved. special attention is given to gastric acid, infection with helicobacter ... | 1992 | 1644343 |
| evaluation of a commercially available second-generation immunoglobulin g enzyme immunoassay for detection of helicobacter pylori infection. | we evaluated a commercially available second-generation anti-h. pylori immunoglobulin g enzyme immunoassay (eia) (cobas core anti-helicobacter pylori eia; roche s. a., basel, switzerland) for serodiagnosis of h. pylori infection. the results of the assay were assessed in relation to the results of bacterial culture, urease testing, and histological giemsa stain of gastric biopsy specimens from 1,134 patients with a variety of symptoms relating to the upper gastrointestinal tract. h. pylori was d ... | 1992 | 1734050 |
| 15nh4+ excretion test: a new method for detection of helicobacter pylori infection. | a noninvasive test for the detection of helicobacter pylori infection that uses [15n]urea as a tracer has been established. the principle the test is based on is the strong urease activity of h. pylori. after oral ingestion, [15n]urea is broken down into ammonia and carbon dioxide by h. pylori urease in the stomach. the ammonia is absorbed into the blood and excreted in the urine. the amount of [15n]urea, reflecting the magnitude of h. pylori infection, is evaluated by measuring the abundance an ... | 1992 | 1734051 |
| diagnosis of helicobacter pylori infection in adult and pediatric patients by using pyloriset, a rapid latex agglutination test. | pyloriset (orion diagnostica, espoo, finland) is a rapid antibody test using latex particles coated with acid-extracted antigen of helicobacter pylori. we evaluated its ability to predict infection in 100 adult patients and 50 pediatric patients referred for gastric endoscopy. sixty of 65 h. pylori-infected adults were correctly identified by the test. there were 12 false-positive and 5 false-negative reactions seen. pyloriset had a sensitivity of 92% and a specificity of 66%. the positive predi ... | 1992 | 1734072 |
| effect of helicobacter pylori on serum pepsinogen i and plasma gastrin in duodenal ulcer patients. | duodenal ulcer patients have increased serum pepsinogen i (pgi) concentrations and an increased prevalence of helicobacter pylori infection. we have examined the effect of eradicating the infection on pgi. in 12 duodenal ulcer patients in whom h. pylori was successfully eradicated, the median basal pgi was 90 ng/ml (range, 37-252) before treatment and fell to 74 ng/ml (28-197) 1 month after treatment (p less than 0.01). in 12 patients in whom therapy failed to eradicate the infection, the pgi wa ... | 1992 | 1736337 |
| [helicobacter pylori allergy]. | a case of a 44 year old woman with antrum gastritis and h. pylori infection was reported. after unsuccessful treatment of the disorder with bismuth and tinidazole, an auto-vaccine was prepared from the bacterium in order to eliminate the infection. after the first injection of the vaccine a generalised urticaria was observed. in the development of the skin eruptions a type i, and a type iv allergic reaction could be demonstrated using the h. pylori specific rast-test and leukocyte migration inhi ... | 1992 | 1741153 |
| histological classification of chronic gastritis: an iconoclastic view. | 1992 | 1727770 | |
| helicobacter pylori and luminal gastric ph. relationships in nonulcer dyspepsia. | the relationships between gastric ph and helicobacter pylori infection were studied in 37 consecutive subjects affected with nonulcer dyspepsia. each underwent esophagogastroduodenoscopy with multiple gastric biopsies for both h. pylori and histologic assessment, and 24-hr antral ph monitoring. h. pylori was harbored by 59.5% of the subjects with whole gastric spread of infection in all but one patient. histologic gastritis was shown in 70.3% of the subjects. h. pylori was strongly associated wi ... | 1992 | 1735361 |
| compositional analysis of helicobacter pylori rough-form lipopolysaccharides. | sodium dodecyl sulfate-polyacrylamide gel electrophoresis was used to analyze the macromolecular heterogeneity of lipopolysaccharides (lps) from seven fresh clinical isolates and three culture collection strains of the human pathogen helicobacter pylori. all the clinical isolates produced smooth-form lps with o side chains of relatively homogeneous chain length, whereas the culture collection strains yielded rough-form lps. a better yield of the latter lps was obtained when combined protease pre ... | 1992 | 1735724 |
| a prospective randomized study of the injurious effects of aspirin and naproxen on the gastroduodenal mucosa in patients with rheumatoid arthritis. | a prospective double-blind randomized placebo-controlled study was conducted to compare the injurious effects of aspirin and naproxen on the gastroduodenal mucosa. patients with rheumatoid arthritis attending the immunology clinic of a tertiary care center were included in the study. ninety consecutive patients were randomized to receive aspirin, naproxen, or placebo. clinical evaluation was done every 2 wk. upper gastrointestinal endoscopy, biopsies from the gastric antrum and duodenum for hist ... | 1992 | 1642224 |
| helicobacter muridarum sp. nov., a microaerophilic helical bacterium with a novel ultrastructure isolated from the intestinal mucosa of rodents. | helical organisms with novel ultrastructural characteristics were isolated from the intestinal mucosa of rats and mice. these bacteria were characterized by the presence of 9 to 11 periplasmic fibers which appeared as concentric helical ridges on the surface of each cell. the cells were motile with a rapid corkscrewlike motion and had bipolar tufts of 10 to 14 sheathed flagella. the bacteria were microaerophilic, nutritionally fastidious, and physiologically similar to helicobacter species and w ... | 1992 | 1736969 |
| intestinal metaplasia and helicobacter pylori: an endoscopic bioptic study of the gastric antrum. | to study the relationship between intestinal metaplasia and helicobacter pylori infection, 2274 gastroscopic antral biopsies taken from 533 patients were examined. overall, intestinal metaplasia was found in 135 patients (25.3%) and h pylori in 289 patients (54.2%). the prevalence of intestinal metaplasia and h pylori was age related, being more common in patients greater than or equal to 50 years compared with patients less than 50 years (intestinal metaplasia, p less than 0.001 and h pylori, p ... | 1992 | 1740271 |
| association of helicobacter pylori with hla-dr antigen expression in gastritis. | to assess the association between helicobacter pylori-associated gastritis and hla-dr antigen (class ii antigen) expression. | 1992 | 1740510 |
| visual endoscopic indicator of helicobacter pylori infection. | 1992 | 1642216 | |
| treponema pallidum and helicobacter pylori recovered in a case of chronic active gastritis. | a 49-year-old man complaining of epigastric pain underwent endoscopy, during which thickened stomach folds below the fundus were observed. microscopic examination of gastric tissue biopsy specimens revealed chronic active gastritis. dieterle stain revealed overwhelming numbers of "corkscrew-like" spirochetes. these were proved to be consistent with treponema pallidum. a comprehensive study of the tissue revealed the added presence of helicobacter pylori. this appears to be the first case report ... | 1992 | 1728852 |
| topographic mapping of helicobacter pylori colonization in long-term-infected pigs. | four barrier-born pigs were inoculated with helicobacter pylori during gastroscopy. infection in all pigs was established after 3 weeks, and the animals were kept isolated from other pigs in ordinary experimental sites. the pigs were sacrificed and examined 3, 5, 6, and 6.5 months postinoculation. a detailed urease mapping of the pig stomachs showed a patchy distribution of h. pylori. the bacteria colonized in all pigs, with a concentration of h. pylori-positive areas in the antrum and fundus. f ... | 1992 | 1730499 |
| h. pylori, the most common bacterial infection in africa: a random serological study. | this study was carried out to determine the prevalence of antibodies to helicobacter pylori in northern nigeria, a region with a low incidence of peptic ulceration. in a random, serological survey of 268 subjects, 228 (85%) of the population studied had igg antibodies to h. pylori. fifty-eight of these subjects had experienced dyspepsia in the preceding 6 months. the majority of the population (82%) is infected between the ages of 5 and 10. despite the high prevalence of antibodies to h. pylori, ... | 1992 | 1728121 |
| factors influencing the eradication of helicobacter pylori with triple therapy. | helicobacter pylori infection has been associated with gastritis, duodenal ulcer, gastric ulcer, and the epidemic form of gastric carcinoma. eradication of h. pylori infection has proven to be difficult. recently, combinations of antimicrobial drugs have been shown to eradicate greater than 50% of infections; however, the results have proven variable, and the factors influencing effectiveness of therapy are unclear. in the present study, the effectiveness of a triple therapy for eradication of h ... | 1992 | 1732120 |
| hypotheses on the pathogenesis and natural history of helicobacter pylori-induced inflammation. | although helicobacter pylori is now recognized as playing an etiologic role in chronic gastritis and peptic ulcer disease, information on the pathogenesis and natural history of infection is limited. a model is proposed in which luminal h. pylori secrete substances that mediate inflammation that is beneficial to the organism but ultimately deleterious for the host; in addition to tissue damage, inflammation also affects gastric secretory function. in this model, the host may attempt to suppress ... | 1992 | 1732141 |
| helicobacter pylori gastric atrophy and pernicious anemia. | 1992 | 1732153 | |
| evaluation of the performance of commercial test kits for detection of helicobacter pylori antibodies in serum. | we have compared the sensitivities, specificities, and predictive values of three commercial serological assays for the diagnosis of helicobacter pylori infection. a qualitative latex method (pyloriset; orion diagnostics), a semiquantitative enzyme-linked immunosorbent assay (elisa) (gap test igg; bio-rad), and a quantiative elisa (helico-g; porton cambridge) were used in 109 untreated dyspeptic patients. the presence of h. pylori was established when the results of culture and/or histology of t ... | 1992 | 1624571 |
| sensitive detection of helicobacter pylori by using polymerase chain reaction. | a polymerase chain reaction (pcr) for the specific detection of helicobacter pylori was developed with a single primer pair derived from the nucleotide sequence of the urease a gene of h. pylori. we achieved specific amplification of a 411-bp dna fragment in h. pylori. after 35 cycles of amplification, the product could be detected by agarose gel electrophoresis and contained conserved single hinfi and alui restriction sites. this fragment was amplified in all 50 strains of h. pylori tested, but ... | 1992 | 1734052 |
| symptoms and risk factors of helicobacter pylori infection in a cohort of epidemiologists. | to identify symptoms and risk factors associated with helicobacter pylori infection, a cohort of 341 epidemiologists was studied. all subjects had one banked serum (collected between 1969 and 1987) and one recent serum sample (collected in 1988) evaluated for h. pylori immunoglobulin g by enzyme-linked immunosorbent assay; subjects provided information on gastrointestinal symptoms and risk factors for gastritis and peptic ulcer disease. prevalence of infection decreased from the early 1970s to t ... | 1992 | 1727779 |
| helicobacter pylori and gastric lymphonodular hyperplasia in children. | the association of gastric lymphonodular hyperplasia and helicobacter pylori infection has been reported only in children. lymphonodular hyperplasia of the stomach is a well known radiographic and endoscopic entity. over the past three decades, it has been associated with many conditions, ranging from a normal variant to a premalignant lesion. we have recently encountered five children with gastric lymphonodular hyperplasia, all of whom had h. pylori infection of the antrum. the literature regar ... | 1992 | 1728111 |
| cytology: a simple, rapid, sensitive method in the diagnosis of helicobacter pylori. | cytology and the rapid urease test on gastric biopsies may diagnose helicobacter pylori (h. pylori) infection within an hour. we evaluated the sensitivity and reproducibility of touch cytology (imprints from biopsies). in 19 patients with duodenal ulcer, biopsies were obtained from the antrum, fundus, and bulb. h. pylori was diagnosed in 42 sites on smears: 28 by culture and 23 by histology. h. pylori was present in the antrum and fundus in 16 and in the bulb in 11. assessment of paired antral b ... | 1992 | 1728119 |
| helicobacter pylori and duodenal ulcer recurrence. | preliminary evidence suggests that eradication of helicobacter pylori (h. pylori) may lead to prolonged remission of duodenal ulcer (du). the aim of this study was to assess the long-term effect of eradication of h. pylori on the natural history of du. fifty-one patients with endoscopically proven duodenal ulcers, who were found to have h. pylori infection on histology and culture, and who were successfully eradicated of h. pylori with combination treatment of colloidal bismuth subcitrate and an ... | 1992 | 1728120 |
| inhibition of helicobacter pylori glycosulfatase activity toward gastric sulfomucin by nitecapone. | a glycosulfatase activity toward gastric sulfomucin was identified in the extracellular material elaborated by h. pylori. the enzyme exhibited maximum activity at ph 5.7 in the presence of triton x-100 and cacl2, and displayed on sds-page an apparent molecular weight of 30kda. the h. pylori glycosulfatase effectively caused desulfation of n-acetylglucosamine-6-sulfate and galactose-6-sulfate of the carbohydrate chains of mucins, as well as that of glucose-6-sulfate of glyceroglucolipids, but was ... | 1992 | 1632804 |
| motility as a factor in the colonisation of gnotobiotic piglets by helicobacter pylori. | non-motile variants of helicobacter pylori (strain 26695) occurred with a frequency of 1.6 (sd 0.4) x 10(-4) variants/cell/division cycle, and reversion to the motile form occurred with a frequency of less than 10(-7) variants/cell/division cycle. the two forms remained greater than 90% pure for up to 50 cell divisions and differed only in the presence or absence of motility and flagella. bacteria were recovered from nine of 10 gnotobiotic piglets inoculated orally with motile h. pylori, but fro ... | 1992 | 1629897 |
| cytopathic effects of helicobacter pylori on cultured mammalian cells. | cytopathic effects of broth-culture filtrates from eight clinical isolates and one reference strain of helicobacter pylori on three cultured mammalian cell lines were investigated. all the strains, including nctc 11637, produced cytotoxic factors that caused intracellular vacuolation on these cell lines. ags and sflep cells were more sensitive than hep-2 cells. to examine the role of urease in the cytotoxic effect, a urease-negative mutant was produced. filtrates from both wild-type and mutant s ... | 1992 | 1629896 |
| [helicobacter pylori spectrum: from gastritis to malignancy]. | 1992 | 1625512 | |
| surface proteins from helicobacter pylori exhibit chemotactic activity for human leukocytes and are present in gastric mucosa. | the mechanism by which helicobacter pylori, a noninvasive bacterium, initiates chronic antral gastritis in humans is unknown. we now show that h. pylori releases products with chemotactic activity for monocytes and neutrophils. this chemotactic activity was inhibited by antisera to either h. pylori whole bacteria or h. pylori-derived urease. moreover, surface proteins extracted from h. pylori and purified h. pylori urease (a major component of the surface proteins) exhibited dose-dependent, anti ... | 1992 | 1732414 |
| [the non-ulcer dyspepsia syndrome]. | 1992 | 1635780 | |
| [clinical significance of serological markers of helicobacter pylori]. | helicobacter pylori (h. pylori) is a gram-negative, curved bacillus known since 1983. it is supposed to play role in the pathogenesis of certain gastroduodenic diseases, e.g. non-ulcer dyspepsia (nud), chronic inflammation, ulcers, etc. serum samples of 70 patients who were examined for stomach complaints with gastroscopy and those of 22 healthy persons were analysed. the purpose of the study was to evaluate anti-h. pylori igg, igm and iga antibodies using elisa method. whether the antibodies ca ... | 1992 | 1635774 |
| haemagglutination profiles of helicobacter species that cause gastritis in man and animals. | thirty-five helicobacter pylori isolates, 21 h. mustelae isolates and four strains of h. felis were compared for their ability to agglutinate red blood cells (rbcs). isolates were examined in a slide haemagglutination assay with rbcs from 11 animal species, including rodents, carnivores and primates, as well as man. rbcs were agglutinated by 65-90% of h. mustelae isolates and 16-57% of h. pylori isolates. treatment of h. mustelae with pronase and heat inhibited haemagglutination (ha) whereas hea ... | 1992 | 1279175 |
| histamine h2-receptor antagonists in peptic ulcer disease. efficacy in healing peptic ulcers. | duodenal ulcer healing depends on the degree and length of inhibition of gastric secretion and upon the duration of therapy, while gastric ulcer healing is dependent mainly on the duration of therapy. currently marketed doses of the histamine h2-receptor antagonists heal between 77 and 92% of duodenal ulcers at 4 weeks, and adjuvant treatment to eradicate helicobacter pylori increases this rate. once-daily administration is as effective as more frequent dosing regimens and may even result in hig ... | 1992 | 1280563 |
| antigenicity of helicobacter pylori lipopolysaccharides. | an investigation of the sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page) profiles of lipopolysaccharides (lpss) extracted from seven strains of helicobacter pylori revealed that these molecules were silver stainable and exhibited a high degree of variability in their patterns. two strains synthesized a variety of sizes of lps molecules such that fractionation by sds-page resulted in a stepwise gradation of bands which extended from the top to the bottom of the silver-stained ... | 1992 | 1280651 |
| dna fingerprints of helicobacter pylori before and after treatment with omeprazole. | to test whether a hypoacidic environment may potentially "stress" helicobacter pylori dna, encouraging the emergence of strain variation. | 1992 | 1282520 |
| influence of colloidal bismuth subcitrate on enzyme secretion from isolated rat pancreatic acinar cells. | bismuth salts are currently used as monotherapy or in combination with antibiotics for the treatment of helicobacter pylori-associated peptic ulcer disease. besides encouraging clinical results with colloidal bismuth subcitrate (cbs), there is an ongoing fear of organ toxicity with the use of bismuth salts. to study potential toxic effects of cbs under short-term exposure, we tested the influence of cbs on amylase secretion from isolated rat pancreatic acinar cells under basal conditions and fol ... | 1992 | 1282729 |
| role of helicobacter pylori in duodenal ulcer. | 1992 | 1282863 | |
| follicular gastritis and its association with helicobacter pylori infection. | fifty endoscopic biopsies with follicular gastritis (fg) were reviewed to define the frequency of association of fg and helicobacter pylori (h pylori) infection. all biopsies were studied in sections stained with hematoxylin and eosin and no special techniques were employed. in forty-two out of the fifty cases (84%) h pylori was documented and most of the gastritis showed activity. there was no correlation between the quantity of follicles and the number of bacilli; some biopsies with few follic ... | 1992 | 1283226 |
| extranodal lymphomas: the malt concept. | extranodal lymphomas account for as many as 40% of non-hodgkin's lymphomas and most arise in the gastro-intestinal tract which is a major lymphoid organ in its own right. gastrointestinal (gut) associated lymphoid tissue (galt) and that of other mucosae (malt), differs both structurally and functionally from nodal lymphoid tissue and low grade b cell lymphomas arising in the gastrointestinal tract and other mucosae have been found to recapitulate the structure and cytological features of malt. m ... | 1992 | 1283245 |
| [clinical importance of helicobacter pylori infections in childhood]. | within the last ten years an increasing number of helicobacter pylori-related inflammatory gastroduodenal diseases in children has been reported. the aim of this paper is to describe the range of helicobacter pylori infections in children including diagnosis and treatment by application of colloidal bismuth salts. | 1992 | 1289643 |
| does the stomach adapt to helicobacter pylori? | to shed some light on the question of gastric adaptation to helicobacter pylori infection, an overview is given of the various histopathological and clinical consequences of h. pylori infection in man. h. pylori infection can be considered as a chronic bacterial infection. for many individuals there is a balance between a low degree of infection and a low degree of inflammation. the microbial or host factors in adaptation of this balance are largely unknown. if and how 'downregulation' of the in ... | 1992 | 1290055 |
| gastric carcinoma: failed adaptation to helicobacter pylori. | helicobacter pylori is the major cause of chronic gastritis. unlike bacterial infections in general, h. pylori acquisition causes a chronic, usually life-long infection. after acquisition, chronic inflammation (gastritis) appears and develops slowly into atrophic gastritis (with intestinal metaplasia) in a proportion of affected subjects. inflammation and atrophy result from a failure of the immune system to eliminate the h. pylori infection. in infected stomach, several cascades of reactions ar ... | 1992 | 1290056 |
| acid secretion, 1932-92: advances, adaptations, and paradoxes. | this paper reviews the evolution of our understanding of various aspects of gastric acid secretion over the past 60 years. embryologic aspects and neonatal acid secretion are considered, and the relationship between parietal cell mass and acid secretion and the changing concepts of parietal cell activation are discussed. the effect of aging on acid secretion and the relevance of acid secretion in health and disease are reviewed, and current views on adaptation to therapeutic inhibition of acid s ... | 1992 | 1290062 |
| use of an ammonia electrode for rapid quantification of helicobacter pylori urease: its use in the endoscopy room and in the assessment of urease inhibition by bismuth subsalicylate. | the use of an ammonia electrode to quantify ammonia liberated by urease from helicobacter pylori was assessed in an in vitro study. it was found to be highly sensitive (down to 0.7 ppm nh3) and highly reproducible (coefficient of variation 6.0%). inhibition of urease by bismuth subsalicylate was evaluated as urease testing is often used to assess clearance of h. pylori in patients treated with bismuth. concentrations of bismuth subsalicylate up to 5 mg/ml had no inhibitory effect but bismuth sub ... | 1992 | 1291402 |
| helicobacter pylori infection and gastroduodenal disease: a comparison of endoscopic findings, histology, and urease test data. | to determine the prevalence and significance of helicobacter pylori (h. pylori) infection, biopsies of the antral mucosa were obtained from 139 patients and 43 asymptomatic volunteers. the specimens were examined by hematoxylin-eosin staining and the ureas test. the detection rate of h. pylori by histologic examination was 91.3% in patients with duodenal ulcer, 75.0% in those with combined duodenal and gastric ulcer, 63.6% in those with gastric ulcer, 22.9% in those with gastric carcinoma, 36.4% ... | 1992 | 1293070 |
| helicobacter pylori and peptic ulcer diseases: prevalence and association with antral gastritis in 210 patients. | evidence is accumulating that helicobacter pylori infection plays a major contributory role in peptic ulcer disease [duodenal ulcer (du) and gastric ulcer (gu)] and non-ulcer dyspepsia (nud). we, therefore, studied prospectively 210 consecutive patients with upper gastrointestinal symptoms (62 du, 38 gu and 110 nud) to determine the prevalence of h. pylori infection and to investigate their association with histological gastritis. using endoscopic biopsy of the gastric antrum for diagnosing h. p ... | 1992 | 1293255 |