Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| research contributing to improvements in controlling florida's mosquitoes and mosquito-borne diseases. | research on mosquitoes and mosquito-borne diseases has contributed to improvements in providing effective, efficient, and environmentally proper mosquito control. florida has benefitted from several research accomplishments that have increased the state's mosquito control capabilities. research with florida's mosquitoes has resulted in the development of ecologically sound management of mosquito impoundments on florida's east coast. this strategy, called rotational impoundment management (rim), ... | 2016 | 27690112 |
| dengueme: a tool for the modeling and simulation of dengue spatiotemporal dynamics. | the prevention and control of dengue are great public health challenges for many countries, particularly since 2015, as other arboviruses have been observed to interact significantly with dengue virus. different approaches and methodologies have been proposed and discussed by the research community. an important tool widely used is modeling and simulation, which help us to understand epidemic dynamics and create scenarios to support planning and decision making processes. with this aim, we propo ... | 2016 | 27649226 |
| aedes aegypti d7 saliva protein inhibits dengue virus infection. | aedes aegypti is the primary vector of several medically relevant arboviruses including dengue virus (denv) types 1-4. ae. aegypti transmits denv by inoculating virus-infected saliva into host skin during probing and feeding. ae. aegypti saliva contains over one hundred unique proteins and these proteins have diverse functions, including facilitating blood feeding. previously, we showed that ae. aegypti salivary gland extracts (sges) enhanced dissemination of denv to draining lymph nodes. in con ... | 2016 | 27632170 |
| population genetic structure of aedes fluviatilis (diptera: culicidae). | although aedes fluviatilis is an anthropophilic mosquito found abundantly in urban environments, its biology, epidemiological potential and genetic characteristics are poorly understood. climate change and urbanization processes that result in environmental modifications benefit certain anthropophilic mosquito species such as ae. fluviatilis, greatly increasing their abundance in urban areas. to gain a better understanding of whether urbanization processes modulate the genetic structure of this ... | 2016 | 27598889 |
| plant virus-insect vector interactions: current and potential future research directions. | acquisition and transmission by an insect vector is central to the infection cycle of the majority of plant pathogenic viruses. plant viruses can interact with their insect host in a variety of ways including both non-persistent and circulative transmission; in some cases, the latter involves virus replication in cells of the insect host. replicating viruses can also elicit both innate and specific defense responses in the insect host. a consistent feature is that the interaction of the virus wi ... | 2016 | 27834855 |
| downregulation of aedes aegypti chromodomain helicase dna binding protein 7/kismet by wolbachia and its effect on dengue virus replication. | dengue virus (denv) is a mosquito-transmitted virus imposing a significant burden on human health around the world. since current control strategies are not sufficient, there is an urgent need to find alternative methods to control denv transmission. it has been demonstrated that introduction of wolbachia pipientis in aedes aegypti mosquitoes can impede denv transmission with the mechanism(s) not fully understood. recently, a number of studies have found the involvement of chromodomain dna bindi ... | 2016 | 27827425 |
| zika virus epidemic in brazil. i. fatal disease in adults: clinical and laboratorial aspects. | zika virus (zikv) was first detected in brazil in may 2015 and the country experienced an explosive epidemic. however, recent studies indicate that the introduction of zikv occurred in late 2013. cases of microcephaly and deaths associated with zikv infection were identified in brazil in november, 2015. | 2016 | 27835759 |
| transmission bottlenecks and rnai collectively influence tick-borne flavivirus evolution. | arthropod-borne rna viruses exist within hosts as heterogeneous populations of viral variants and, as a result, possess great genetic plasticity. understanding the micro-evolutionary forces shaping these viruses can provide insights into how they emerge, adapt, and persist in new and changing ecological niches. while considerable attention has been directed toward studying the population dynamics of mosquito-borne viruses, little is known about tick-borne virus populations. therefore, using a mo ... | 2016 | 28058113 |
| distribution of the members of the pipiens assemblage in the sympatric area from argentina: which is where and when? | given their medical and veterinary relevance, the members of the pipiens assemblage are a worldwide target of ecological research. the distribution of culex pipiens s.s. and cx. quinquefasciatus converge in buenos aires, argentina, where hybrids have been detected. each member of the assemblage exhibits a distinct eco-physiological behaviour that can affect its efficiency in pathogen transmission. our aim was to identify the environmental drivers for the spatio-temporal distribution of each memb ... | 2016 | 27783720 |
| transstadial transmission and long-term association of crimean-congo hemorrhagic fever virus in ticks shapes genome plasticity. | the trade-off hypothesis, the current paradigm of arbovirus evolution, proposes that cycling between vertebrate and invertebrate hosts presents significant constraints on genetic change of arboviruses. studying these constraints in mosquito-borne viruses has led to a new understanding of epizootics. the trade-off hypothesis is assumed to be applicable to tick-borne viruses too, although studies are lacking. tick-borne crimean-congo hemorrhagic fever virus (cchfv), a member of the family bunyavir ... | 2016 | 27775001 |
| combining attractants and larvicides in biodegradable matrices for sustainable mosquito vector control. | there is a global need for cost-effective and environmentally friendly tools for control of mosquitoes and mosquito-borne diseases. one potential way to achieve this is to combine already available tools to gain synergistic effects to reduce vector mosquito populations. another possible way to improve mosquito control is to extend the active period of a given control agent, enabling less frequent applications and consequently, more efficient and longer lasting vector population suppression. | 2016 | 27768698 |
| looking backward, looking forward: the long, torturous struggle with mosquitoes. | the american anti-mosquito movement grew out of the discovery of the role of mosquitoes in transferring pathogens and public concern about pest and nuisance mosquitoes in the late 1800s. in the 20th century, organized mosquito control in the united states passed through three eras: mechanical, chemical, and integrated mosquito control. mosquito control in the 21st century faces the challenge of emerging pathogens, invasive mosquito species, and balancing concerns about the environment with effec ... | 2016 | 27775554 |
| zika antiviral chemotherapy: identification of drugs and promising starting points for drug discovery from an fda-approved library. | background the recent epidemics of zika virus (zikv) implicated it as the cause of serious and potentially lethal congenital conditions such microcephaly and other central nervous system defects, as well as the development of the guillain-barré syndrome in otherwise healthy patients. recent findings showed that anti-dengue antibodies are capable of amplifying zikv infection by a mechanism similar to antibody-dependent enhancement, increasing the severity of the disease. this scenario becomes pot ... | 2016 | 27909576 |
| how did zika virus emerge in the pacific islands and latin america? | the unexpected emergence of zika virus (zikv) in the pacific islands and latin america and its association with congenital zika virus syndrome (czvs) (which includes microcephaly) and guillain-barré syndrome (gbs) have stimulated wide-ranging research. high densities of susceptible aedes spp., immunologically naive human populations, global population growth with increased urbanization, and escalation of global transportation of humans and commercial goods carrying vectors and zikv undoubtedly e ... | 2016 | 27729507 |
| forecasting united states heartworm dirofilaria immitis prevalence in dogs. | this paper forecasts next year's canine heartworm prevalence in the united states from 16 climate, geographic and societal factors. the forecast's construction and an assessment of its performance are described. | 2016 | 27724981 |
| massive yet grossly underestimated global costs of invasive insects. | insects have presented human society with some of its greatest development challenges by spreading diseases, consuming crops and damaging infrastructure. despite the massive human and financial toll of invasive insects, cost estimates of their impacts remain sporadic, spatially incomplete and of questionable quality. here we compile a comprehensive database of economic costs of invasive insects. taking all reported goods and service estimates, invasive insects cost a minimum of us$70.0 billion p ... | 2016 | 27698460 |
| dna microarray platform for detection and surveillance of viruses transmitted by small mammals and arthropods. | viruses transmitted by small mammals and arthropods serve as global threats to humans. most emergent and re-emergent viral agents are transmitted by these groups; therefore, the development of high-throughput screening methods for the detection and surveillance of such viruses is of great interest. in this study, we describe a dna microarray platform that can be used for screening all viruses transmitted by small mammals and arthropods (smaviruschip) with nucleotide sequences that have been depo ... | 2016 | 27654806 |
| detection of invasive mosquito vectors using environmental dna (edna) from water samples. | repeated introductions and spread of invasive mosquito species (ims) have been recorded on a large scale these last decades worldwide. in this context, members of the mosquito genus aedes can present serious risks to public health as they have or may develop vector competence for various viral diseases. while the tiger mosquito (aedes albopictus) is a well-known vector for e.g. dengue and chikungunya viruses, the asian bush mosquito (ae. j. japonicus) and ae. koreicus have shown vector competenc ... | 2016 | 27626642 |
| new paradigms for virus detection, surveillance and control of zika virus vectors in the settings of southeast asia. | zika virus (zikv) has now become a global public health concern. the vectors for zikv are aedes aegypti and a. albopictus. both these mosquitoes are predominant in southeast asia and are also responsible for the spread of other arboviral diseases like dengue virus and chikungunya virus. the incidence of dengue has been increasing over the years and this is of concern to public health workers. simple laboratory tools for the detection of zikv is also lacking. in the absence of drugs and vaccine f ... | 2016 | 27679623 |
| nonstructural proteins are preferential positive selection targets in zika virus and related flaviviruses. | the flavivirus genus comprises several human pathogens such as dengue virus (denv), japanese encephalitis virus (jev), and zika virus (zikv). although zikv usually causes mild symptoms, growing evidence is linking it to congenital birth defects and to increased risk of guillain-barré syndrome. zikv encodes a polyprotein that is processed to produce three structural and seven nonstructural (ns) proteins. we investigated the evolution of the viral polyprotein in zikv and in related flaviviruses (d ... | 2016 | 27588756 |
| molecular signatures associated with zikv exposure in human cortical neural progenitors. | zika virus (zikv) infection causes microcephaly and has been linked to other brain abnormalities. how zikv impairs brain development and function is unclear. here we systematically profiled transcriptomes of human neural progenitor cells exposed to asian zikv(c), african zikv(m), and dengue virus (denv). in contrast to the robust global transcriptome changes induced by denv, zikv has a more selective and larger impact on expression of genes involved in dna replication and repair. while overall e ... | 2016 | 27580721 |
| zika fetal neuropathogenesis: etiology of a viral syndrome. | the ongoing zika virus epidemic in the americas and the observed association with both fetal abnormalities (primary microcephaly) and adult autoimmune pathology (guillain-barré syndrome) has brought attention to this neglected pathogen. while initial case studies generated significant interest in the zika virus outbreak, larger prospective epidemiology and basic virology studies examining the mechanisms of zika viral infection and associated pathophysiology are only now starting to be published. ... | 2016 | 27560129 |
| modeling mosquito-borne disease spread in u.s. urbanized areas: the case of dengue in miami. | expansion of mosquito-borne pathogens into more temperate regions of the world necessitates tools such as mathematical models for understanding the factors that contribute to the introduction and emergence of a disease in populations naïve to the disease. often, these models are not developed and analyzed until after a pathogen is detected in a population. in this study, we develop a spatially explicit stochastic model parameterized with publicly available u.s. census data for studying the poten ... | 2016 | 27532496 |
| a community-based prospective cohort study of dengue viral infection in malaysia: the study protocol. | globally, dengue infections constitute a significant public health burden. in recent decades, malaysia has become a dengue hyper-endemic country with the co-circulation of the four dengue virus serotypes. the cyclical dominance of sub-types contributes to a pattern of major outbreaks. the consequences can be observed in the rising incidence of reported dengue cases and dengue related deaths. understanding the complex interaction of the dengue virus, its human hosts and the mosquito vectors at th ... | 2016 | 27510731 |
| development and utility of an in vitro, fluorescence-based assay for the discovery of novel compounds against dengue 2 viral protease. | dengue disease is one of the most significant vector-borne illnesses in the world. the emergence and re-emergence of dengue infections in many parts of the world affect millions annually and continue to burden public health systems especially in low-income populations. advances in dengue vaccine development showed promising results; however, protection seems to be suboptimal. there is no licensed chemotherapeutic agent against dengue to date. an ideal scenario of combinatorial vaccination of hig ... | 2016 | 27551237 |
| larval application of sodium channel homologous dsrna restores pyrethroid insecticide susceptibility in a resistant adult mosquito population. | mosquitoes host and pass on to humans a variety of disease-causing pathogens such as infectious viruses and other parasitic microorganisms. the emergence and spread of insecticide resistance is threatening the effectiveness of current control measures for common mosquito vector borne diseases, such as malaria, dengue and zika. therefore, the emerging resistance to the widely used pyrethroid insecticides is an alarming problem for public health. herein we demonstrated the use of rna interference ... | 2016 | 27416771 |
| animals in the zika virus life cycle: what to expect from megadiverse latin american countries. | zika virus (zikv) was first isolated in 1947 in primates in uganda, west africa. the virus remained confined to the equatorial regions of africa and asia, cycling between infecting monkeys, arboreal mosquitoes, and occasionally humans. the zikv asiatic strain was probably introduced into brazil in or around late 2013. presently, zikv is in contact with the rich biodiversity in all brazilian biomes, bordering on other latin american countries. infections in brazilian primates have been reported r ... | 2016 | 28005902 |
| artificial diets for mosquitoes. | mosquito-borne diseases are responsible for more than a million human deaths every year. modern mosquito control strategies such as sterile insect technique (sit), release of insects carrying a dominant lethal (ridl), population replacement strategies (pr), and wolbachia-based strategies require the rearing of large numbers of mosquitoes in culture for continuous release over an extended period of time. anautogenous mosquitoes require essential nutrients for egg production, which they obtain thr ... | 2016 | 28009851 |
| diversity of cultivable midgut microbiota at different stages of the asian tiger mosquito, aedes albopictus from tezpur, india. | aedes aegypti and ae. albopictus are among the most important vectors of arboviral diseases, worldwide. recent studies indicate that diverse midgut microbiota of mosquitoes significantly affect development, digestion, metabolism, and immunity of their hosts. midgut microbiota has also been suggested to modulate the competency of mosquitoes to transmit arboviruses, malaria parasites etc. interestingly, the midgut microbial flora is dynamic and the diversity changes with the development of vectors ... | 2016 | 27941985 |
| flaviviruses as a cause of undifferentiated fever in sindh province, pakistan: a preliminary report. | arboviral diseases are expanding worldwide, yet global surveillance is often limited due to diplomatic and cultural barriers between nations. with human encroachment into new habitats, mosquito-borne viruses are also invading new areas. the actual prevalence of expanding arboviruses is unknown in pakistan due to inappropriate diagnosis and poor testing for arboviral diseases. the primary objective of this study was to document evidence of flavivirus infections as the cause of undifferentiated fe ... | 2016 | 26909342 |
| changes in the proteome of langat-infected ixodes scapularis ise6 cells: metabolic pathways associated with flavivirus infection. | ticks (family ixodidae) transmit a variety of disease causing agents to humans and animals. the tick-borne flaviviruses (tbfs; family flaviviridae) are a complex of viruses, many of which cause encephalitis and hemorrhagic fever, and represent global threats to human health and biosecurity. pathogenesis has been well studied in human and animal disease models. equivalent analyses of tick-flavivirus interactions are limited and represent an area of study that could reveal novel approaches for tbf ... | 2016 | 26859745 |
| the asian tiger hunts in maputo city--the first confirmed report of aedes (stegomyia) albopictus (skuse, 1895) in mozambique. | increasing evidence suggests that dengue fever is endemic in mozambique. larvae of both the afrotropical vector aedes aegypti and its subspecies, ae. aegypti formosus, have been reported from three provinces in mozambique, two of which recently experienced dengue outbreaks. despite reports of the invasive oriental vector ae. albopictus on the islands in the mozambique channel and nearby indian ocean, the species has not yet been reported in mozambique. | 2016 | 26856329 |
| cross-protection induced by japanese encephalitis vaccines against different genotypes of dengue viruses in mice. | dengue viruses (denvs) and japanese encephalitis virus (jev) are closely related mosquito-borne flaviviruses that cause very high global disease burdens. although cross-reactivity and cross-protection within flaviviruses have been demonstrated, the effect of jev vaccination on susceptibility to denv infection has not been well elucidated. in this study, we found that vaccination with the jev inactivated vaccine (inv) and live attenuated vaccine (lav) could induce cross-immune responses and cross ... | 2016 | 26818736 |
| long-lasting immune protection and other epidemiological findings after chikungunya emergence in a cambodian rural community, april 2012. | the east/central/south african genotype of chikungunya virus with the e1-a226v mutation emerged in 2011 in cambodia and spread in 2012. an outbreak of 190 cases was documented in trapeang roka, a rural village. we surveyed 425 village residents within 3-4 weeks after the outbreak, and determined the sensitivity and specificity of case definitions and factors associated with infection by chikv. self-reported clinical presentation consisted mostly of fever, rash and arthralgia. the presence of all ... | 2016 | 26752630 |
| behavioral response of aedes aegypti mosquito towards essential oils using olfactometer. | aedes aegypti mosquito is responsible for transmitting human diseases like dengue and chikungunya. personal or space protection with insect repellents is a practical approach to reducing human mosquito contact, thereby minimizing disease transmission. essential oils are natural volatile substances from plants used as protective measure against blood-sucking mosquitoes. | 2016 | 27308295 |
| screening of methanolic plant extracts against larvae of aedes aegypti and anopheles stephensi in mysore. | mosquitoes transmit serious human diseases, causing millions of death every year. vector control is facing a threat due to the emergence of resistance to synthetic insecticides. insecticides of botanical origin may serve as suitable alternative biocontrol techniques in the future. nine different locally available medicinally important plants suspected to posse larvicidal property were screened against fourth instar larvae of aedes aegypti and anopheles stephensi to a series of concentrations of ... | 2016 | 27308289 |
| insecticide resistance and management strategies in urban ecosystems. | the increased urbanization of a growing global population makes imperative the development of sustainable integrated pest management (ipm) strategies for urban pest control. this emphasizes pests that are closely associated with the health and wellbeing of humans and domesticated animals. concurrently there are regulatory requirements enforced to minimize inadvertent exposures to insecticides in the urban environment. development of insecticide resistance management (irm) strategies in urban eco ... | 2016 | 26751480 |
| analysis of genotype diversity and evolution of dengue virus serotype 2 using complete genomes. | dengue is one of the most common arboviral diseases prevalent worldwide and is caused by dengue viruses (genus flavivirus, family flaviviridae). there are four serotypes of dengue virus (denv-1 to denv-4), each of which is further subdivided into distinct genotypes. denv-2 is frequently associated with severe dengue infections and epidemics. denv-2 consists of six genotypes such as asian/american, asian i, asian ii, cosmopolitan, american and sylvatic. comparative genomic study was carried out t ... | 2016 | 27635316 |
| detection of chikungunya virus circulation using sugar-baited traps during a major outbreak in french guiana. | 2016 | 27606960 | |
| sequence diversity of dengue virus type 2 in brain and thymus of infected interferon receptor ko mice: implications for dengue virulence. | we previously reported that a clinical isolate of dengue virus (denv) is capable of causing acute-phase systemic infection in mice harboring knockouts of the genes encoding type-i and -ii interferon ifn receptors (ifn-α/β/γr ko mice); in contrast, other virulent denv isolates exhibited slow disease progression in this mice, yielding lethal infection around 20 days post-infection (p.i.). in the present study, we sought to clarify the dynamics of slow disease progression by examining disease progr ... | 2016 | 27903277 |
| febrile illness diagnostics and the malaria-industrial complex: a socio-environmental perspective. | global prioritization of single-disease eradication programs over improvements to basic diagnostic capacity in the global south have left the world unprepared for epidemics of chikungunya, ebola, zika, and whatever lies on the horizon. the medical establishment is slowly realizing that in many parts of sub-saharan africa (ssa), particularly urban areas, up to a third of patients suffering from acute fever do not receive a correct diagnosis of their infection. | 2016 | 27855644 |
| persistence of neutralizing antibody against dengue virus 2 after 70 years from infection in nagasaki. | this study aimed to investigate the duration of humoral immune responses to dengue virus (denv) infection in japanese who experienced acute febrile illness with hemorrhagic manifestations 70 years ago, when an epidemic of dengue occurred in nagasaki, japan, from 1942 to 1944. a japanese volunteer requested serological diagnosis of denv infection in 2014 and donated blood sample to measure the antibody titer against denv by antiflavi igg indirect elisa, focus reduction neutralization test, and pl ... | 2016 | 27493841 |
| assessment of angelica sinensis (oliv.) diels as a repellent for personal protection against mosquitoes under laboratory and field conditions in northern thailand. | angelica sinensis (oliv.) hexane extract (ahe) has been reported as a proven and impressive repellent against laboratory-reared female aedes aegypti mosquitoes. with the aim of promoting products of plant origin as a viable alternative to conventional synthetic substances, this study was designed to transform ahe-based repellents for exploitable commercial production by enhancing their efficacy and assessing their physical and biological stability as well as repellency against mosquitoes under l ... | 2016 | 27357395 |
| dengue virus genome uncoating requires ubiquitination. | the process of genome release or uncoating after viral entry is one of the least-studied steps in the flavivirus life cycle. flaviviruses are mainly arthropod-borne viruses, including emerging and reemerging pathogens such as dengue, zika, and west nile viruses. currently, dengue virus is one of the most significant human viral pathogens transmitted by mosquitoes and is responsible for about 390 million infections every year around the world. here, we examined for the first time molecular aspect ... | 2016 | 27353759 |
| flavivirus ns1 protein in infected host sera enhances viral acquisition by mosquitoes. | the arbovirus life cycle involves viral transfer between a vertebrate host and an arthropod vector, and acquisition of virus from an infected mammalian host by a vector is an essential step in this process. here, we report that flavivirus nonstructural protein-1 (ns1), which is abundantly secreted into the serum of an infected host, plays a critical role in flavivirus acquisition by mosquitoes. the presence of dengue virus (denv) and japanese encephalitis virus ns1s in the blood of infected inte ... | 2016 | 27562253 |
| prevention and control of zika as a mosquito-borne and sexually transmitted disease: a mathematical modeling analysis. | the ongoing zika virus (zikv) epidemic in the americas poses a major global public health emergency. while zikv is transmitted from human to human by bites of aedes mosquitoes, recent evidence indicates that zikv can also be transmitted via sexual contact with cases of sexually transmitted zikv reported in argentina, canada, chile, france, italy, new zealand, peru, portugal, and the usa. yet, the role of sexual transmission on the spread and control of zikv infection is not well-understood. we i ... | 2016 | 27312324 |
| role of aedes aegypti (linnaeus) and aedes albopictus (skuse) in local dengue epidemics in taiwan. | aedes mosquitoes in taiwan mainly comprise aedes albopictus and ae. aegypti. however, the species contributing to autochthonous dengue spread and the extent at which it occurs remain unclear. thus, in this study, we spatially analyzed real data to determine spatial features related to local dengue incidence and mosquito density, particularly that of ae. albopictus and ae. aegypti. | 2016 | 27829399 |
| low sensitivity of the tourniquet test for differential diagnosis of dengue: an analysis of 28,000 trials in patients. | the aim of this study was to evaluate the utility of the tourniquet test (tt) for dengue diagnosing. to our knowledge, no previous study with such a large sample, of this duration, with as many laboratory methods referenced, or relating the results of the tt to the 2009 who classification of severity has been conducted thus far. | 2016 | 27809813 |
| vertical transmission of zika virus in aedes aegypti mosquitoes. | previous experimental studies have demonstrated that a number of mosquito-borne flavivirus pathogens are vertically transmitted in their insect vectors, providing a mechanism for these arboviruses to persist during adverse climatic conditions or in the absence of a susceptible vertebrate host. in this study, designed to test whether zika virus (zikv) could be vertically transmitted, female aedes aegypti and aedes albopictus were injected with zikv, and their f1 adult progeny were tested for zikv ... | 2016 | 27573623 |
| unsuspected dengue as a cause of acute febrile illness in children and adults in western nicaragua. | dengue is an emerging infectious disease of global significance. suspected dengue, especially in children in nicaragua's heavily-urbanized capital of managua, has been well documented, but unsuspected dengue among children and adults with undifferentitated fever has not. | 2016 | 27792777 |
| vector competence of american mosquitoes for three strains of zika virus. | in 2015, zika virus (zikv; flaviviridae; flavivirus) emerged in the americas, causing millions of infections in dozens of countries. the rapid spread of the virus and the association with disease outcomes such as guillain-barré syndrome and microcephaly make understanding transmission dynamics essential. currently, there are no reports of vector competence (vc) of american mosquitoes for zikv isolates from the americas. further, it is not clear whether zikv strains from other genetic lineages ca ... | 2016 | 27783679 |
| a review of the mosquito species (diptera: culicidae) of bangladesh. | diseases caused by mosquito-borne pathogens remain an important source of morbidity and mortality in bangladesh. to better control the vectors that transmit the agents of disease, and hence the diseases they cause, and to appreciate the diversity of the family culicidae, it is important to have an up-to-date list of the species present in the country. original records were collected from a literature review to compile a list of the species recorded in bangladesh. | 2016 | 27770829 |
| zika virus (zikv). | 2016 | 27994533 | |
| looking for inhibitors of the dengue virus ns5 rna-dependent rna-polymerase using a molecular docking approach. | the dengue virus (denv) nonstructural protein 5 (ns5) contains both an n-terminal methyltransferase domain and a c-terminal rna-dependent rna polymerase domain. polymerase activity is responsible for viral rna synthesis by a de novo initiation mechanism and represents an attractive target for antiviral therapy. the incidence of denv has grown rapidly and it is now estimated that half of the human population is at risk of becoming infected with this virus. despite this, there are no effective dru ... | 2016 | 27784988 |
| zika virus on a spreading spree: what we now know that was unknown in the 1950's. | zika virus (zikv) is a mosquito-borne flavivirus that is transmitted through the bite of aedes spp mosquitoes and less predominantly, through sexual intercourse. prior to 2007, zikv was associated with only sporadic human infections with minimal or no clinical manifestations. recently the virus has caused disease outbreaks from the pacific islands, the americas, and off the coast of west africa with approximately 1.62 million people suspected to be infected in more than 60 countries around the g ... | 2016 | 27716242 |
| full genome sequence and sfrna interferon antagonist activity of zika virus from recife, brazil. | the outbreak of zika virus (zikv) in the americas has transformed a previously obscure mosquito-transmitted arbovirus of the flaviviridae family into a major public health concern. little is currently known about the evolution and biology of zikv and the factors that contribute to the associated pathogenesis. determining genomic sequences of clinical viral isolates and characterization of elements within these are an important prerequisite to advance our understanding of viral replicative proces ... | 2016 | 27706161 |
| management of infection by the zika virus. | a panel of national experts was convened by the brazilian infectious diseases society in order to organize the national recommendations for the management of zika virus infection. the focus of this document is the diagnosis, both clinical and laboratorial, and appropriate treatment of the diverse manifestations of this infection, ranging from acute mild disease to guillain-barré syndrome and also microcephaly and congenital malformations. | 2016 | 27686610 |
| the golgi associated eri3 is a flavivirus host factor. | dengue virus (denv) is a mosquito-borne flavivirus classified into four serotypes (denv-1-4) that causes dengue fever (df), dengue hemorrhagic fever (dhf) or dengue shock syndrome (dss). an estimated 390 million people are at risk for infection with denv and there are no effective vaccines or therapeutics. we utilized rna chromatography coupled with quantitative mass spectrometry (qms) to identify host rna binding proteins (rbps) that interact with denv-2 rna. we identified eri3 (also prnpip and ... | 2016 | 27682269 |
| discovery of novel viruses in mosquitoes from the zambezi valley of mozambique. | mosquitoes carry a wide variety of viruses that can cause vector-borne infectious diseases and affect both human and veterinary public health. although mozambique can be considered a hot spot for emerging infectious diseases due to factors such as a rich vector population and a close vector/human/wildlife interface, the viral flora in mosquitoes have not previously been investigated. in this study, viral metagenomics was employed to analyze the viral communities in culex and mansonia mosquitoes ... | 2016 | 27682810 |
| genetic characterization of spondweni and zika viruses and susceptibility of geographically distinct strains of aedes aegypti, aedes albopictus and culex quinquefasciatus (diptera: culicidae) to spondweni virus. | zika virus (zikv) has extended its known geographic distribution to the new world and is now responsible for severe clinical complications in a subset of patients. while substantial genetic and vector susceptibility data exist for zikv, less is known for the closest related flavivirus, spondweni virus (sponv). both zikv and sponv have been known to circulate in africa since the mid-1900s, but neither has been genetically characterized by gene and compared in parallel. furthermore, the susceptibi ... | 2016 | 27783682 |
| genetically modified (gm) mosquito use to reduce mosquito-transmitted disease in the us: a community opinion survey. | mosquito-borne infectious diseases such as dengue, chikungunya, and now zika, pose a public health threat to the us, particularly florida, the gulf coast states, and hawaii. recent autochthonous transmission of dengue and chikungunya in florida, the recent dengue outbreak in hawaii, and the potential for future local spread of zika in the us, has led to the consideration of novel approaches to mosquito management. one such novel approach, the release of sterile genetically modified mosquitoes, h ... | 2016 | 27366585 |
| predicting dengue fever outbreaks in french guiana using climate indicators. | dengue fever epidemic dynamics are driven by complex interactions between hosts, vectors and viruses. associations between climate and dengue have been studied around the world, but the results have shown that the impact of the climate can vary widely from one study site to another. in french guiana, climate-based models are not available to assist in developing an early warning system. this study aims to evaluate the potential of using oceanic and atmospheric conditions to help predict dengue f ... | 2016 | 27128312 |
| spread of the invasive mosquitoes aedes aegypti and aedes albopictus in the black sea region increases risk of chikungunya, dengue, and zika outbreaks in europe. | 2016 | 27115737 | |
| external quality assessment of dengue and chikungunya diagnostics in the asia pacific region, 2015. | to conduct an external quality assessment (eqa) of dengue and chikungunya diagnostics among national-level public health laboratories in the asia pacific region following the first round of eqa for dengue diagnostics in 2013. | 2016 | 27508088 |
| the mitotic spindle: linking teratogenic effects of zika virus with human genetics? | recently, an association between zika virus infection and microcephaly/ocular findings was found to be reasonable e.g. because of the demonstration that the virus was found in the brain of a fetus after presumed maternal infection. although there is no proof yet for a causal relationship, for an appropriate risk calculation efforts are urgently needed to either establish or disprove this assumption. | 2016 | 27099632 |
| characterization of lethal zika virus infection in ag129 mice. | mosquito-borne zika virus (zikv) typically causes a mild and self-limiting illness known as zika fever, which often is accompanied by maculopapular rash, headache, and myalgia. during the current outbreak in south america, zikv infection during pregnancy has been hypothesized to cause microcephaly and other diseases. the detection of zikv in fetal brain tissue supports this hypothesis. because human infections with zikv historically have remained sporadic and, until recently, have been limited t ... | 2016 | 27093158 |
| microcephaly and zika virus: neonatal neuroradiological aspects. | the aim of this study is to describe some radiological features in the newborns with microcephaly caused by zika virus infection during pregnancy. | 2016 | 27080092 |
| clinical features and neuroimaging (ct and mri) findings in presumed zika virus related congenital infection and microcephaly: retrospective case series study. | to report radiological findings observed in computed tomography (ct) and magnetic resonance imaging (mri) scans of the first cases of congenital infection and microcephaly presumably associated with the zika virus in the current brazilian epidemic. | 2016 | 27075009 |
| a cost-effectiveness tool for informing policies on zika virus control. | as zika virus continues to spread, decisions regarding resource allocations to control the outbreak underscore the need for a tool to weigh policies according to their cost and the health burden they could avert. for example, to combat the current zika outbreak the us president requested the allocation of $1.8 billion from congress in february 2016. | 2016 | 27205899 |
| time to empower release of insects carrying a dominant lethal and wolbachia against zika. | ridl (release of insects with dominant lethality) and wolbachia are 2 potentially powerful tools in the fight against zika, but their technological advancement is being hampered by policy barriers. in this study, we discuss what could be done to overcome these regulatory deadlocks. | 2016 | 27419175 |
| estimated zika virus importations to europe by travellers from brazil. | given the interconnectivity of brazil with the rest of the world, zika virus (zikv) infections have the potential to spread rapidly around the world via viremic travellers. the extent of spread depends on the travel volume and the endemicity in the exporting country. in the absence of reliable surveillance data, we did mathematical modelling to estimate the number of importations of zikv from brazil into europe. | 2016 | 27193266 |
| personal protection of permethrin-treated clothing against aedes aegypti, the vector of dengue and zika virus, in the laboratory. | the dengue and zika viruses are primarily transmitted by aedes aegypti mosquitoes, which are most active during day light hours and feed both in and outside of the household. personal protection technologies such as insecticide-treated clothing could provide individual protection. here we assessed the efficacy of permethrin-treated clothing on personal protection in the laboratory. | 2016 | 27187593 |
| the persistence and ecological impacts of a cyanobacterium genetically engineered to express mosquitocidal bacillus thuringiensis toxins. | the cyanobacterium anabaena pcc 7120#11 has been genetically engineered to act as a delivery vehicle for bacillus thuringiensis subspecies israelensis mosquitocidal toxins. to address ecological concerns about releasing this genetically engineered microorganism into the environment for mosquito larva control, the persistence and ecological impacts of pcc 7120#11 was evaluated using multi-species, standardized aquatic microcosms. | 2016 | 27165108 |
| the viral polymerase inhibitor 7-deaza-2'-c-methyladenosine is a potent inhibitor of in vitro zika virus replication and delays disease progression in a robust mouse infection model. | zika virus (zikv) is an emerging flavivirus typically causing a dengue-like febrile illness, but neurological complications, such as microcephaly in newborns, have potentially been linked to this viral infection. we established a panel of in vitro assays to allow the identification of zikv inhibitors and demonstrate that the viral polymerase inhibitor 7-deaza-2'-c-methyladenosine (7dma) efficiently inhibits replication. infection of ag129 (ifn-α/β and ifn-γ receptor knock-out) mice with zikv res ... | 2016 | 27163257 |
| zika virus, elevation, and transmission risk. | zika virus has appeared in the americas in the form of a major outbreak, and is now known to cause birth defects when pregnant women are infected. as a result, the centers for disease control and prevention issued travel guidelines, in the form of an elevational risk definition: destinations below 2000m are considered as at-risk. | 2016 | 27280061 |
| wolbachia modulates lipid metabolism in aedes albopictus mosquito cells. | certain strains of the intracellular endosymbiont wolbachia can strongly inhibit or block the transmission of viruses such as dengue virus (denv) by aedes mosquitoes, and the mechanisms responsible are still not well understood. direct infusion and liquid chromatography-fourier transform ion cyclotron resonance (ft-icr) mass spectrometry-based lipidomics analyses were conducted using aedes albopictus aa23 cells that were infected with the wmel and wmelpop strains of wolbachia in comparison to un ... | 2016 | 26994075 |
| assessing chikungunya risk in a metropolitan area of argentina through satellite images and mathematical models. | chikungunya fever is a viral disease that recently invaded the american continent. in america, it is transmitted mainly by the mosquito aedes aegypti, but aedes albopictus is the main vector in other regions of the world. this work estimates the risk of disease emergence and the corresponding population at risk for the case of a naive population in the metropolitan area of buenos aires, the capital city of argentina. | 2016 | 26830024 |
| whole-genome sequencing analysis from the chikungunya virus caribbean outbreak reveals novel evolutionary genomic elements. | chikungunya virus (chikv), an alphavirus and member of the togaviridae family, is capable of causing severe febrile disease in humans. in december of 2013 the asian lineage of chikv spread from the old world to the americas, spreading rapidly throughout the new world. given this new emergence in naïve populations we studied the viral genetic diversity present in infected individuals to understand how chikv may have evolved during this continuing outbreak. | 2016 | 26807575 |
| chikungunya: epidemiology. | chikungunya virus is a mosquito-borne alphavirus that causes fever and debilitating joint pains in humans. joint pains may last months or years. it is vectored primarily by the tropical and sub-tropical mosquito, aedes aegypti, but is also found to be transmitted by aedes albopictus, a mosquito species that can also be found in more temperate climates. in recent years, the virus has risen from relative obscurity to become a global public health menace affecting millions of persons throughout the ... | 2016 | 26918158 |
| prevalence of dengue and chikungunya virus infections in north-eastern tanzania: a cross sectional study among participants presenting with malaria-like symptoms. | in spite of increasing reports of dengue and chikungunya activity in tanzania, limited research has been done to document the general epidemiology of dengue and chikungunya in the country. this study aimed at determining the sero-prevalence and prevalence of acute infections of dengue and chikungunya virus among participants presenting with malaria-like symptoms (fever, headache, rash, vomit, and joint pain) in three communities with distinct ecologies of north-eastern tanzania. | 2016 | 27112553 |
| molecular characterisation of clinical isolates of chikungunya virus: a study from tertiary care hospitals in southern india. | indian ocean islands and india have experienced massive severe chikungunya outbreak from 2005 up till now and then chikungunya became epidemic in india. the mutations that occurred in e1 gene were responsible for increased infectivity, virulence and host adaptability. it is important to find out the genotype and its probable evolvement and novel mutations in the e1 gene reported during 2006-2009 from the current isolates, which may affect the local protein structure. | 2016 | 27134872 |
| forecasting chikungunya spread in the americas via data-driven empirical approaches. | chikungunya virus (chikv) is endemic to africa and asia, but the asian genotype invaded the americas in 2013. the fast increase of human infections in the american epidemic emphasized the urgency of developing detailed predictions of case numbers and the potential geographic spread of this disease. | 2016 | 26928307 |
| first imported case of chikungunya virus infection in a travelling canadian returning from the caribbean. | this is the first canadian case of chikungunya virus (chikv) infection reported in a traveller returning from the caribbean. following multiple mosquito bites in martinique island in january 2014, the patient presented with high fever, headaches, arthralgia on both hands and feet, and a rash on the trunk upon his return to canada. initial serological testing for dengue virus infection was negative. support therapy with nonsteroidal anti-inflammatory drugs was administered. the symptoms gradually ... | 2016 | 27366163 |
| aedes mosquitoes and zika virus infection: an a to z of emergence? | 2016 | 26905027 | |
| vector competence of aedes aegypti in transmitting chikungunya virus: effects and implications of extrinsic incubation temperature on dissemination and infection rates. | aedes aegypti is a competent arthropod vector of chikungunya virus (chikv). the rate at which the virus disseminate in the vector is limited by temperature of their environment which can be an important determinant of geographical and seasonal limits to transmission by the arthropods in the tropics. this study investigated the vector competence of ae. aegypti for chikv at ambient temperature of 32 and 26 °c (coastal and western kenya respectively) reared at extrinsic incubation temperature (eit) ... | 2016 | 27357190 |
| development of neutralization assay using an egfp chikungunya virus. | chikungunya virus (chikv), a member of the alphavirus genus, is an important human emerging/re-emerging pathogen. currently, there are no effective antiviral drugs or vaccines against chikv infection. herein, we construct an infectious clone of chikv and an egfp reporter chikv (egfp-chikv) with an isolated strain (assigned to asian lineage) from chikv-infected patients. the egfp-chikv reporter virus allows for direct visualization of viral replication through the levels of egfp expression. using ... | 2016 | 27367716 |
| isolation of infective zika virus from urine and saliva of patients in brazil. | zika virus (zikv) is an emergent threat provoking a worldwide explosive outbreak. since january 2015, 41 countries reported autochthonous cases. in brazil, an increase in guillain-barré syndrome and microcephaly cases was linked to zikv infections. a recent report describing low experimental transmission efficiency of its main putative vector, ae. aegypti, in conjunction with apparent sexual transmission notifications, prompted the investigation of other potential sources of viral dissemination. ... | 2016 | 27341420 |
| seroprevalence of anti-chikungunya virus antibodies in children and adults in managua, nicaragua, after the first chikungunya epidemic, 2014-2015. | chikungunya is a viral disease transmitted by aedes aegypti and ae. albopictus mosquitoes. in late 2013, chikungunya virus (chikv) was introduced into the caribbean island of st. martin. since then, approximately 2 million chikungunya cases have been reported by the pan american health organization, and most countries in the americas report autochthonous transmission of chikv. in nicaragua, the first imported case was described in july 2014 and the first autochthonous case in september 2014. her ... | 2016 | 27322692 |
| antiviral hammerhead ribozymes are effective for developing transgenic suppression of chikungunya virus in aedes aegypti mosquitoes. | the chikungunya virus (chikv) is an emerging pathogen with widespread distribution in regions of africa, india, and asia that threatens to spread into temperate climates with the introduction of its major vector, aedes albopictus. chikv causes a disease frequently misdiagnosed as dengue fever, with potentially life-threatening symptoms that can result in a longer-term debilitating arthritis. the increasing risk of spread from endemic regions via human travel and commerce and the current absence ... | 2016 | 27294950 |
| dengue vaccine: considerations before rollout in colombia. | 2016 | 27280803 | |
| novel lesions of bones and joints associated with chikungunya virus infection in two mouse models of disease: new insights into disease pathogenesis. | chikungunya virus is an arbovirus spread predominantly by aedes aegypti and ae. albopictus mosquitoes, and causes debilitating arthralgia and arthritis. while these are common manifestations during acute infection and it has been suggested they can recur in patients chronically, gaps in knowledge regarding the pathogenesis still exist. two established mouse models were utilized (adult irf 3/7 -/- -/- and wild-type c57bl/6j mice) to evaluate disease manifestations in bones and joints at various t ... | 2016 | 27182740 |
| identification and characterization of two novel rna viruses from anopheles gambiae species complex mosquitoes. | mosquitoes of the anopheles gambiae complex display strong preference for human bloodmeals and are major malaria vectors in africa. however, their interaction with viruses or role in arbovirus transmission during epidemics has been little examined, with the exception of o'nyong-nyong virus, closely related to chikungunya virus. deep-sequencing has revealed different rna viruses in natural insect viromes, but none have been previously described in the anopheles gambiae species complex. here, we d ... | 2016 | 27138938 |
| leukemoid reaction in chikungunya fever. | chikungunya is a viral illness caused by an arbovirus which is transmitted by aedes mosquito. fever and polyarthralgia are hallmark of this viral illness. viral infections are generally associated with leucopenia and bacterial infections with leukocytosis. leukemoid reaction (lr) is defined by reactive increase in leukocyte count of more than 50,000/cu mm with increase in mature leukocytes on peripheral blood. leukocytosis is common in chikungunya but leukemoid reaction has not been reported in ... | 2016 | 27437276 |
| the genetic basis of host preference and resting behavior in the major african malaria vector, anopheles arabiensis. | malaria transmission is dependent on the propensity of anopheles mosquitoes to bite humans (anthropophily) instead of other dead end hosts. recent increases in the usage of long lasting insecticide treated nets (llins) in africa have been associated with reductions in highly anthropophilic and endophilic vectors such as anopheles gambiae s.s., leaving species with a broader host range, such as anopheles arabiensis, as the most prominent remaining source of transmission in many settings. an. arab ... | 2016 | 27631375 |
| bacterial larvicide, bacillus thuringiensis israelensis strain am 65-52 water dispersible granule formulation impacts both dengue vector, aedes aegypti (l.) population density and disease transmission in cambodia. | a multi-phased study was conducted in cambodia from 2005-2011 to measure the impact of larviciding with the bacterial larvicide, bacillus thuringiensis israelensis (bti), a water dispersible granule (wg) formulation on the vector, aedes aegypti (l.) and the epidemiology. in our studies, all in-use containers were treated at 8 g/1000 l, including smaller containers and animal feeders which were found to contribute 23% of ae aegypti pupae. the treated waters were subjected to routine water exchang ... | 2016 | 27627758 |
| zika: an old virus with a new face. | zika virus is a mosquito-borne flavivirus that represents a public health emergency at the ongoing epidemic. this obscure virus was limited to sporadic cases in africa and asia, until the emergence of zika virus in brazil in 2015, when it rapidly spread throughout the americas. most zika virus infections are subclinical or characterized by mild febrile illness. however, neurological complications, including guillain-barré syndrome in adults, and congenital anomalies, including microcephaly in ba ... | 2016 | 27703544 |
| isolation of zika virus imported from tonga into australia. | the globally emergent zika virus (zikv) is a threat to australia, given the number of imported cases from epidemic regions and the presence of competent mosquito vectors. we report the isolation of zikv from a female traveler who recently returned from tonga to brisbane, queensland, australia in 2016. | 2016 | 27679739 |
| use of transgenic aedes aegypti in brazil: risk perception and assessment. | the ox513a strain of aedes aegypti, which was developed by the british company oxitec, expresses a self-limiting transgene that prevents larvae from developing to adulthood. in april 2014, the brazilian national technical commission on biosafety completed a risk assessment of ox513a and concluded that the strain did not present new biological risks to humans or the environment and could be released in brazil. at that point, brazil became the first country to approve the unconstrained release of ... | 2016 | 27843167 |
| an ecological assessment of the pandemic threat of zika virus. | the current outbreak of zika virus poses a severe threat to human health. while the range of the virus has been cataloged growing slowly over the last 50 years, the recent explosive expansion in the americas indicates that the full potential distribution of zika remains uncertain. moreover, many studies rely on its similarity to dengue fever, a phylogenetically closely related disease of unknown ecological comparability. here we compile a comprehensive spatially-explicit occurrence dataset from ... | 2016 | 27564232 |
| complete genome sequences of three historically important, spatiotemporally distinct, and genetically divergent strains of zika virus: mr-766, p6-740, and prvabc-59. | here, we report the 10,807-nucleotide-long consensus rna genome sequences of three spatiotemporally distinct and genetically divergent zika virus strains, with the functionality of their genomic sequences substantiated by reverse genetics: mr-766 (african lineage, uganda, 1947), p6-740 (asian lineage, malaysia, 1966), and prvabc-59 (asian lineage-derived american strain, puerto rico, 2015). | 2016 | 27540058 |