Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| the potential of alcohol release doorplates to reduce surface contamination during hand contact. | optimal hand hygiene may be compromised by contact with contaminated environmental surfaces. | 2017 | 28760635 |
| acquisition of clostridium difficile colonization and infection after transfer from a veterans affairs hospital to an affiliated long-term care facility. | background clostridium difficile infection (cdi) and asymptomatic carriage of toxigenic c. difficile are common in long-term care facilities (ltcfs). however, whether c. difficile is frequently acquired in the ltcf versus during acute-care admissions remains unknown. objective to test the hypothesis that ltcf residents often acquire c. difficile colonization and infection in the ltcf design this 5-month cohort study was conducted to determine the incidence of acquisition of c. difficile coloniza ... | 2017 | 28693636 |
| risk of surgical site infection, acute kidney injury, and clostridium difficile infection following antibiotic prophylaxis with vancomycin plus a beta-lactam versus either drug alone: a national propensity-score-adjusted retrospective cohort study. | the optimal regimen for perioperative antimicrobial prophylaxis is controversial. use of combination prophylaxis with a beta-lactam plus vancomycin is increasing; however, the relative risks and benefits associated with this strategy are unknown. thus, we sought to compare postoperative outcomes following administration of 2 antimicrobials versus a single agent for the prevention of surgical site infections (ssis). potential harms associated with combination regimens, including acute kidney inju ... | 2017 | 28692690 |
| detection of toxigenic clostridium difficile in paediatric patients. | our main objective was a revision of clinical, microbiological and epidemiological results of clostridium difficile-associated infection in paediatric patients (2010-2015). we compared the diagnoses performed by detection of toxins in feces and those performed by real-time pcr. | 2017 | 28689671 |
| room occupancy-associated transmission of mdro, clostridium difficile, or norovirus: results from a room surveillance project. | 2017 | 28689514 | |
| vancomycin vs metronidazole for clostridium difficile infection: focus on recurrence and mortality. | 2017 | 28681270 | |
| increasing incidence of clostridium difficile ribotype 001 associated with severe course of the infection and previous fluoroquinolone use in the czech republic, 2015. | the aim of the study was to provide an update on the epidemiology of c. difficile infection (cdi) in a representative number of hospitals within the czech republic in 2015. in 2015, twenty-eight czech hospitals were invited to participate in a cdi study. laboratories sent the first 20 consecutive c. difficile isolates for characterization by capillary-electrophoresis (ce) ribotyping and the presence of toxin genes and collected patient data on previous hospitalization, antibiotic treatment, the ... | 2017 | 28681203 |
| description and validation of a new automated surveillance system for clostridium difficile in denmark. | the surveillance of clostridium difficile (cd) in denmark consists of laboratory based data from departments of clinical microbiology (dcms) sent to the national registry of enteric pathogens (nrep). we validated a new surveillance system for cd based on the danish microbiology database (miba). miba automatically collects microbiological test results from all danish dcms. we built an algorithm to identify positive test results for cd recorded in miba. a cd case was defined as a person with a pos ... | 2017 | 28689506 |
| outcome after discontinuation of proton pump inhibitors at a residential care site: quality improvement project. | increased prescribing of proton pump inhibitors (ppis) in the past few decades can be attributed mainly to long-term use of this type of therapy. recent evidence indicates signals of harm associated with long-term use of ppis, such as increased risk of clostridium difficile infection, recurrence of c. difficile infection, and fracture. a few studies have assessed the effectiveness of step-down management of patients receiving long-term ppi therapy in ambulatory care settings. however, it is unkn ... | 2017 | 28680175 |
| cwp2 from clostridium difficile exhibits an extended three domain fold and cell adhesion in vitro. | colonization of the gut by clostridium difficile requires the adhesion of the bacterium to host cells. a range of cell surface located factors have been linked to adhesion including the s-layer protein lmw slp and the related protein cwp66. as well as these proteins, the s-layer of c. difficile may contain many others. one such protein is cwp2. here, we demonstrate the production of a c. difficile strain 630 cwp2 knockout mutant and assess the effect on the bacterium. the mutant results in incre ... | 2017 | 28677344 |
| clostridium difficile infection in contemporary urologic practice. | clostridium difficile infection (cdi) is a high-impact hospital acquired condition and chief driver of excess morbidity, mortality, and treatment cost. diagnosis, treatment, and prevention of clostridium difficile infection is key component of any hospital based practice. urologists see a small percentage of all patients with cdi, however they traditionally utilize antibiotic agents that put patients at risk for cdi. urologic procedures making use of bowel have a significantly higher rate of cdi ... | 2017 | 28688849 |
| adrenal crisis in metastatic breast cancer. | a female patient with oestrogen receptor-positive and human epidermal growth factor receptor 2 (her2)-positive invasive lobular breast cancer presented with progressive disease on ct scan. some days after initiation of antineoplastic chemotherapy and anti-her2 targeted antibody therapy, the patient presented with profuse diarrhoea, neutropaenia, nausea and weakness. although clostridium difficile was rapidly tackled as a causative agent of gastrointestinal complaints, clinical situation did not ... | 2017 | 28687693 |
| multicenter collaboration study on the β-lactam resistant enterobacteriaceae in japan - the 65th anniversary public interest purpose project of the japanese society of chemotherapy. | this study was conducted using the same method of the "1-day multicenter collaborative research for clostridium difficile infectious". this surveillance study was performed by 38 participating medical facilities across japan. of the 268 fecal specimens collected in this study, 5 (1.9%) carbapenem-resistant enterobacteriaceae (cre) were judged carbapenem resistant by the criteria of the infectious disease act, japan (2 mg/l or more and 64 mg/l or more mics for imipenem and cefmetazole, respective ... | 2017 | 28709901 |
| prevalence and characteristics of clostridium perfringens and clostridium difficile in dogs and cats attended in diverse veterinary clinics from the madrid region. | despite extensive research on the epidemiology of pathogenic clostridia in dogs and cats, most published studies focus on a selected animal population and/or a single veterinary medical centre. we assessed the burden of clostridium perfringens and c. difficile shedding by small animals in 17 veterinary clinics located within the madrid region (spain) and differing in size, number and features of animals attended and other relevant characteristics. in addition, we studied the genetic diversity an ... | 2017 | 28687280 |
| antimicrobial stewardship approaches in the intensive care unit. | antimicrobial stewardship programs aim to monitor, improve, and measure responsible antibiotic use. the intensive care unit (icu), with its critically ill patients and prevalence of multiple drug-resistant pathogens, presents unique challenges. this article reviews approaches to stewardship with application to the icu, including the value of diagnostics, principles of empirical and definitive therapy, and measures of effectiveness. there is good evidence that antimicrobial stewardship results in ... | 2017 | 28687210 |
| recreational sandboxes for children and dogs can be a source of epidemic ribotypes of clostridium difficile. | different studies have suggested that the sand of public playgrounds could have a role in the transmission of infections, particularly in children. furthermore, free access of pets and other animals to the playgrounds might increase such a risk. we studied the presence of clostridium difficile in 20 pairs of sandboxes for children and dogs located in different playgrounds within the madrid region (spain). clostridium difficile isolation was performed by enrichment and selective culture procedure ... | 2017 | 28686001 |
| present and past perspectives on clostridium difficile infection. | clostridium difficile is a gram-positive bacillus that has become one of the main hospital-acquired human gastrointestinal infections in recent years. its incidence is on the rise, involving more virulent strains, affecting new and previously uncontemplated groups of patients, and producing changes in clinical presentation and treatment response that influence disease outcome. early diagnosis and disease stratification based on the severity of c.difficile infection are essential for therapeutic ... | 2017 | 28684034 |
| chemical genomics, structure elucidation, and in vivo studies of the marine-derived anticlostridial ecteinamycin. | a polyether antibiotic, ecteinamycin (1), was isolated from a marine actinomadura sp., cultivated from the ascidian ecteinascidia turbinata. (13)c enrichment, high resolution nmr spectroscopy, and molecular modeling enabled elucidation of the structure of 1, which was validated on the basis of comparisons with its recently reported crystal structure. importantly, ecteinamycin demonstrated potent activity against the toxigenic strain of clostridium difficile nap1/b1/027 (mic = 59 ng/μl), as well ... | 2017 | 28708379 |
| systematic review with meta-analysis: the efficacy of faecal microbiota transplantation for the treatment of recurrent and refractory clostridium difficile infection. | clostridium difficile infection (cdi) is the commonest nosocomial cause of diarrhoea. faecal microbiota transplantation (fmt) is an approved treatment for recurrent or refractory cdi but there is uncertainty about its use. | 2017 | 28707337 |
| clostridium difficile, colitis, and colonoscopy: pediatric perspective. | review tests available for detection of clostridium difficile (c. diff) induced disease, including when such tests should be done in children and how they should be interpreted. | 2017 | 28707191 |
| use of a neutralizing antibody helps identify structural features critical for binding of clostridium difficile toxin tcda to the host cell surface. | clostridium difficile is a clinically significant pathogen that causes mild-to-severe (and often recurrent) colon infections. disease symptoms stem from the activities of two large, multi-domain toxins known as tcda and tcdb. the toxins can bind, enter, and perturb host cell function through a multi-step mechanism of receptor binding, endocytosis, pore formation, autoproteolysis, and glucosyltransferase-mediated modification of host substrates. monoclonal antibodies that neutralize toxin activit ... | 2017 | 28705932 |
| a nutrient-regulated cyclic diguanylate phosphodiesterase controls clostridium difficile biofilm and toxin production during stationary phase. | the signaling molecule cyclic diguanylate (c-di-gmp) mediates physiological adaptation to extracellular stimuli in a wide range of bacteria. the complex metabolic pathways governing c-di-gmp synthesis and degradation are highly regulated, but the specific cues that impact c-di-gmp signaling are largely unknown. in the intestinal pathogen clostridium difficile, c-di-gmp inhibits flagellar motility and toxin production and promotes pilus-dependent biofilm formation, but no specific biological func ... | 2017 | 28652311 |
| probiotic containing lactobacillus casei, lactobacillus bulgaricus, and streptococcus thermophiles (actimel) for the prevention of clostridium difficile associated diarrhoea in the elderly with proximal femur fractures. | the incidence of clostridium difficile associated diarrhoea (cdad) is greater in elderly patients. probiotics may have a beneficial effect in the prevention of cdad. however, their effect in elderly orthopaedic patients has not been previously reported. between april 2013 and april 2014, 105 patients admitted with femoral neck fractures, and who required 3days of antibiotics for infection of any cause, were prescribed the probiotic actimel until 3days after the last antibiotic dose. the incidenc ... | 2017 | 28652125 |
| clostridium difficile-associated colitis post-transplant is not associated with elevation of tacrolimus concentrations. | diarrhea is a common condition after solid organ transplant (sot); clostridium difficile-associated colitis (cdac) is one of the most common infections after sot. we documented previously that some types of enteritis are associated with an elevation of tacrolimus (tac) trough concentrations by interfering with the drug's complex metabolism. | 2017 | 28650734 |
| prevalence and risk factors for colonization by clostridium difficile and extended-spectrum β-lactamase-producing enterobacteriaceae in rehabilitation clinics in germany. | rehabilitation clinics may vary widely in terms of type of care provided, duration of hospital stay, and case severity. few data are available on prevalence of clostridium difficile or extended-spectrum β-lactamase-producing enterobacteriaceae (esbl-e) colonization in rehabilitation clinics in germany. | 2017 | 28705583 |
| intestinal calcium and bile salts facilitate germination of clostridium difficile spores. | clostridium difficile (c. difficile) is an anaerobic gram-positive pathogen that is the leading cause of nosocomial bacterial infection globally. c. difficile infection (cdi) typically occurs after ingestion of infectious spores by a patient that has been treated with broad-spectrum antibiotics. while cdi is a toxin-mediated disease, transmission and pathogenesis are dependent on the ability to produce viable spores. these spores must become metabolically active (germinate) in order to cause dis ... | 2017 | 28704538 |
| treatment of decubitis ulcer stage iv in the patient with polytrauma and vertical share pelvic fracture, diagnosed entherocollitis and deep wound infection with clostridium difficile with combined negative pressure wound therapy (npwt) and faecal management system: case report. | the aim of this paper was to present a case with the successful treatment of decubitis ulcer stage iv in the patient with polytrauma and vertical share pelvic fracture and diagnosed entherocollitis combined with deep wound infection with clostridium difficile treated with combined negative pressure wound therapy (npwt) and faecal management system. | 2017 | 28698756 |
| high in vitro activity of fidaxomicin against clostridium difficile isolates from a university teaching hospital in china. | clostridium difficile infection (cdi) is a significant cause of morbidity and mortality in both the acute care setting and the wider healthcare system. the purpose of this study was to evaluate the in vitro activity of fidaxomicin against c.difficile isolates from a university teaching hospital in china. | 2017 | 28693926 |
| lactic acid production by streptococcus thermophilus alters clostridium difficile infection and in vitro toxin a production. | antibiotic treatment to treat specific infections has the potential to effectively target the offending microbe as well as other microbes that colonize sites within a host. antibiotic-associated diarrhea (aad) is a classic example resulting from disruption of host microbial communities; 20% of patients with aad are likely to become colonized with clostridium difficile. restoration of a "normal" microbial community within the host using probiotic bacteria is one approach to circumvent aad and c. ... | 2017 | 22895082 |
| michigan clostridium difficile hospital discharges: frequency, mortality, and charges, 2002-2008. | clostridium difficile (c. difficile) causes an intestinal bacterial infection of increasing importance in michigan residents and health-care facilities. the specific burden and health-care costs of c. difficile infection (cdi) were previously unknown. we evaluated the frequency, mortality, and health-care charges of cdi from michigan hospital discharge data. | 2017 | 22298923 |
| models for the study of clostridium difficile infection. | models of clostridium difficile infection (c. difficile) have been used extensively for clostridium difficile (c. difficile) research. the hamster model of c. difficile infection has been most extensively employed for the study of c. difficile and this has been used in many different areas of research, including the induction of c. difficile, the testing of new treatments, population dynamics and characterization of virulence. investigations using in vitro models for c. difficile introduced the ... | 2017 | 22555466 |
| clostridium difficile infection: toxins and non-toxin virulence factors, and their contributions to disease establishment and host response. | clostridium difficile infection is the leading cause of antibiotic- and healthcare-associated diarrhea, and its containment and treatment imposes a significant financial burden, estimated to be over $3 billion in the usa alone. since the year 2000, cdi epidemics/outbreaks have occurred in north america, europe and asia. these outbreaks have been variously associated with, or attributed to, the emergence of clostridium difficile strains with increased virulence, an increase in resistance to commo ... | 2017 | 22555464 |
| clinical risk factors for clostridium difficile-associated diseases. | many factors appear to influence the chance of acquiring clostridium difficile (c. difficile) infection, and an accurate identification of risk factors could be beneficial in many ways. thus, in the present study, clinical risk factors for c. difficile-associated disease (cdad) in korea were identified. a total of 93 patients who met the inclusion criteria and 186 age/gender/ward/admission period-matched control patients were included in this study. statistically significant associations were fo ... | 2017 | 22729193 |
| hygienic characteristics and microbiological hazard identification in horse and donkey raw milk. | today the interest toward horse (equus caballus) and donkey (equus asinus) milk for human consumption is receiving a renewed attention because of its particular composition, hypoallergenicity, and nutraceutical properties. the realistic perspective of global use of this aliment in balanced diets, especially for infancy and geriatrics, poses the need for a more in depth knowledge on milk hygiene and on the health status of dairy animals, as a prerequisite of consumers' safety. the aim of this pap ... | 2017 | 27033528 |