Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| discovery of a novel lantibiotic nisin o from blautia obeum a2-162, isolated from the human gastrointestinal tract. | a novel lanc-like sequence was identified from the dominant human gut bacterium blautia obeum strain a2-162. this sequence was extended to reveal a putative lantibiotic operon with biosynthetic and transport genes, two sets of regulatory genes, immunity genes, three identical copies of a nisin-like lana gene with an unusual leader peptide, and a fourth putative lana gene. comparison with other nisin clusters showed that the closest relationship was to nisin u. b. obeum a2-162 demonstrated antimi ... | 2017 | 28857034 |
| impact of a mixed educational and semi-restrictive antimicrobial stewardship project in a large teaching hospital in northern italy. | the overuse of antimicrobials favors the dissemination of antimicrobial resistance, as well as invasive fungal diseases and clostridium difficile infections (cdi). in this study, we assessed the impact of a mixed educational and semi-restrictive antimicrobial stewardship (ams) project in a large teaching hospital in italy. | 2017 | 28856589 |
| characterization of chicken igy specific to clostridium difficile r20291 spores and the effect of oral administration in mouse models of initiation and recurrent disease. | clostridium difficile infection (cdi) are the leading cause of world-wide nosocomial acquired diarrhea. the current main clinical challenge in cdi is the elevated rate of infection recurrence that may reach up to 30% of the patients, which has been associated to the formation of dormant spores during the infection. we sought to characterize the effects of oral administration of specific anti-spore igy in mouse models of cdi and recurrent cdi. the specificity of anti-spore igy was evaluated in vi ... | 2017 | 28856119 |
| cd2068 potentially mediates multidrug efflux in clostridium difficile. | clostridium difficile is a major cause of antibiotic-associated diarrhea and the treatment thereof becomes more difficult owing to a rise of multidrug resistant strains. atp-binding cassette (abc) transporters are known to play a crucial role in the resistance to multiple antibiotics. in this study, the potential contribution of an abc transporter in c. difficile multidrug resistance was investigated. the expression level of the cd2068 gene in c. difficile encoding an abc transporter was up-regu ... | 2017 | 28855575 |
| infection control. | an infection prevention nurse has turned his hand to board game design to help health professionals understand and manage clostridium difficile. | 2017 | 28853357 |
| [clostridium difficile-associated deaths from 2013-2016 in munich and nuremberg : reporting behavior and patient characteristics]. | a number of risk factors for c. difficile infection (cdi) are described in the literature, in particular an antibiotic therapy 4-6 weeks before disease, an age of >65 years, immunosuppression and living in a long-term care facility. increasing incidence rates have been reported for germany. cdi is the fourth most common nosocomial infection with 6.4%. | 2017 | 28852777 |
| fecal microbiota transplantation for clostridium difficile infection in patients with ileal pouches. | background:clostridium difficile infection (cdi) in patients with ileal pouch-anal anastomosis (ipaa) has been increasingly recognized. the aim of this study was to evaluate the outcome of fecal microbiota transplantation (fmt) in patients with pouch and cdi. methods: all consecutive patients that underwent fmt for cdi from 2012 to 2016 were extracted from our irb-approved, prospectively maintained registry of pouch disorders. the primary outcome was negative stool tests for clostridium difficil ... | 2017 | 28852524 |
| hospital-acquired clostridium difficile infection in mainland china: a seven-year (2009-2016) retrospective study in a large university hospital. | clostridium difficile infection (cdi) is associated with risk for severe disease and high mortality. little is known about the extent of hospital-acquired cdi in mainland china. in this study, we aimed to investigate the annual cdi incidence, bacterial genotypes, risk factors for severe cdi and survival over a 7-year period. a total of 307 hospital-acquired cdi patients were enrolled, and 70.7% of these cases were male. cdi incidence was 3.4 per 10,000 admissions. thirty-three different sequence ... | 2017 | 28852010 |
| nosocomial transmission of clostridium difficile genotype st81 in a general teaching hospital in china traced by whole genome sequencing. | clostridium difficile infection (cdi) is increasingly recognized globally as a cause of significant morbidity and mortality. this study aimed to provide insight into the various dynamics of c. difficile transmission and infection in the hospital. we monitored the toxin and resistance profiles as well as evolutionary relationships of c. difficile strains to determine the epidemiology over time in a teaching hospital in shanghai, china between may 2014 and august 2015. the cdi incidence of inpatie ... | 2017 | 28851988 |
| clostridium difficile on youtube: a need for greater focus on prevention. | the purpose of this study was to describe the content of the most popular youtube videos related to clostridium difficile. across all sources, the kinds of content most likely to be included in the videos was general information, overuse of antibiotics, and symptomatic diarrhea. health professionals can contribute to existing social media messages related to c. difficile with comprehensive messages that include means for prevention. | 2017 | 28851505 |
| invading beyond bounds: extraintestinal clostridium difficile infection leading to pancreatic and liver abscesses. | clostridium difficile has become a common healthcare-associated infection over the past few years and gained more attention. c. difficile was estimated to cause almost half a million infections in usa in 2011 and 29 000 died within 30 days of the initial diagnosis. although colitis due to c. difficile is the most common presentation, there have been reported cases of extraintestinal infections. as per our review of literature, this is the third reported case of liver abscess due to the organism. | 2017 | 28847992 |
| chemoprophylaxis in the prevention of clostridium difficile infection: still a ways to go. | 2017 | 28844313 | |
| vancomycin prophylaxis for prevention of clostridium difficile infection recurrence in renal transplant patients. | incidence of primary and recurrent clostridium difficile infection (cdi) is higher in solid-organ transplant recipients than in the average hospitalized patient. strategies for preventing recurrent cdi are limited. prophylaxis with oral vancomycin (vppx) for preventing recurrent cdi may be beneficial, but there is limited evidence supporting its use. | 2017 | 28844154 |
| response to dr. tobar-marcillo and his coauthors: "chemoprophylaxis in the prevention of clostridium difficile infection: still a way to go". | 2017 | 28843660 | |
| changes in intestinal microbiota and their effects on allogeneic stem cell transplantation. | the human intestinal microbiota is essential for microbial homeostasis, regulation of metabolism, and intestinal immune tolerance. rapidly evolving understanding of the importance of the microbiota implicates changes in the composition and function of intestinal microbial communities in an assortment of systemic conditions. complications following allogeneic stem cell transplant now join the ever-expanding list of pathologic states regulated by intestinal microbiota. dysbiosis, or disruption of ... | 2017 | 28842931 |
| functional defects in clostridium difficile tcdb toxin uptake identify cspg4 receptor binding determinants. | clostridium difficile is a major nosocomial pathogen that produces two exotoxins, tcda and tcdb, with tcdb thought to be the primary determinant in human disease. tcda and tcdb are large, multi-domain proteins, each harboring a cytotoxic glucosyltransferase domain that is delivered into the cytosol from endosomes via a translocation domain following receptor-mediated endocytosis of toxins from the cell surface. while there are currently no known host cell receptors for tcda, three cell-surface r ... | 2017 | 28842504 |
| an updated meta-analysis of controlled observational studies: proton-pump inhibitors and risk of clostridium difficile infection. | attention has recently been directed toward a plausible link between clostridium difficile infection (cdi) and proton-pump inhibitors (ppis). however, the results of studies on the association between cdi and ppi remain controversial. | 2017 | 28842261 |
| fecal microbiota transplantation: therapeutic potential for a multitude of diseases beyond clostridium difficile. | the human intestinal tract contains trillions of bacteria, collectively called the gut microbiota. recent insights have linked the gut microbiota to a plethora of diseases, including clostridium difficile infection (cdi), inflammatory bowel disease (ibd), and metabolic diseases such as obesity, type 2 diabetes (t2d), and nonalcoholic steatohepatitis (nash). fecal microbiota transplantation (fmt) is currently tested as a therapeutic option in various diseases and can also help to dissect associat ... | 2017 | 28840809 |
| increased rate of venous thromboembolism in hospitalized inflammatory bowel disease patients with clostridium difficile infection. | risk of venous thromboembolism (vte) in patients with inflammatory bowel disease (ibd) is well established; however, there is paucity of data on the potential added risk of vte in patients with ibd with clostridium difficile infection (cdi). we sought to study the difference in vte rates in hospitalized patients with ibd with cdi compared to those without cdi. | 2017 | 28837518 |
| bezlotoxumab for the treatment of clostridium difficile-associated diarrhea. | diarrhea caused by clostridium difficile is one of the major emerging threats to modern healthcare systems worldwide. although c. difficile spores are present in the gut innocuously, because of repeated broad-spectrum antibiotic therapy, the spores germinate with concomitant release of exotoxin a and b, resulting in mild to severe diarrhea. antibiotic therapy is augmented by addition of the humanized antibodies actoxumab and bezlotoxumab to prevent the action of exotoxins a and b, respectively, ... | 2017 | 28837182 |
| rifaximin treatment is associated with reduced risk of cirrhotic complications and prolonged overall survival in patients experiencing hepatic encephalopathy. | rifaximin might decrease the risk of portal hypertension-related complications by controlling small intestinal bacterial overgrowth. | 2017 | 28836723 |
| disparate subcellular location of putative sortase substrates in clostridium difficile. | clostridium difficile is a gastrointestinal pathogen but how the bacterium colonises this niche is still little understood. sortase enzymes covalently attach specific bacterial proteins to the peptidoglycan cell wall and are often involved in colonisation by pathogens. here we show c. difficile proteins cd2537 and cd3392 are functional substrates of sortase srtb. through manipulation of the c-terminal regions of these proteins we show the spktg motif is essential for covalent attachment to the c ... | 2017 | 28835650 |
| prediction of recurrent clostridium difficile infection using comprehensive electronic medical records in an integrated healthcare delivery system. | background predicting recurrent clostridium difficile infection (rcdi) remains difficult. | 2017 | 28835289 |
| clinical, epidemiological and microbiological characteristics of relapse and re-infection in clostridium difficile infection. | recurrent diarrhea is a common complication of clostridium difficile infection (cdi). recurrent cdi (r-cdi) may be produced by the persistence of spores (relapse) or by the acquisition of a new strain (reinfection). in this study, we analyze epidemiological, clinical, microbiological and laboratory data from patients with r-cdi, relapse, and reinfection-cdi over 5 years and compared with a control group (non r-cdi). among 60 patients with r-cdi, 36 patients had stool samples collected from two o ... | 2017 | 28830842 |
| an outbreak of clostridium difficile infections due to a new pcr ribotype 826: epidemiological and microbiological analyses. | the aim was to investigate an unusual outbreak of 5 patients with in total 8 episodes of a clostridium difficile infection (cdi) on a gastro intestinal surgical ward of a dutch tertiary care university affiliated hospital. | 2017 | 28830806 |
| long-term taxonomic and functional divergence from donor bacterial strains following fecal microbiota transplantation in immunocompromised patients. | immunocompromised individuals are at high risk of developing clostridium difficile-associated disease (cdad). fecal microbiota transplantation (fmt) is a highly effective therapy for refractory or recurrent cdad and, despite safety concerns, has recently been offered to immunocompromised patients. we investigated the genomics of bacterial composition following fmt in immunocompromised patients over a 1-year period. metagenomic, strain and gene-level bacterial dynamics were characterized in two c ... | 2017 | 28827811 |
| intestinal colonisation patterns in breastfed and formula-fed infants during the first 12 weeks of life reveal sequential microbiota signatures. | the establishment of the infant gut microbiota is a highly dynamic process dependent on extrinsic and intrinsic factors. we characterized the faecal microbiota of 4 breastfed infants and 4 formula-fed infants at 17 consecutive time points during the first 12 weeks of life. microbiota composition was analysed by a combination of 16s rrna gene sequencing and quantitative pcr (qpcr). in this dataset, individuality was a major driver of microbiota composition (p = 0.002) and was more pronounced in b ... | 2017 | 28827640 |
| protocol for a randomised, placebo-controlled pilot study for assessing feasibility and efficacy of faecal microbiota transplantation in a paediatric ulcerative colitis population: pedifetch trial. | ulcerative colitis (uc) is a chronic, relapsing condition characterised by colonic inflammation. increasing prevalence in early-age diagnosis provides opportunities for additional complications in later life as a result of prolonged exposure to inflammatory and therapeutic insults, necessitating novel avenues for therapeutics which may result in fewer side effects. faecal microbiota transplantation (fmt) has previously demonstrated potential therapeutic benefit in an adult randomised-controlled ... | 2017 | 28827258 |
| probiotics and antibiotic-associated diarrhea in children: a review and new evidence on lactobacillus rhamnosus gg during and after antibiotic treatment. | antibiotic associated diarrhea (aad) is a common complication in childhood in the outpatient and inpatient settings. this review provides up to date information on the use of probiotics in the prevention and treatment of aad, including that from clostridium difficile, in children. the most recently systematic reviews and subsequently published randomized controlleds trials are considered. different single and multistrain probiotics are described; a specific recommendation for the use of lactobac ... | 2017 | 28827186 |
| what makes a tweet fly? analysis of twitter messaging at four infection control conferences. | objective to examine tweeting activity, networks, and common topics mentioned on twitter at 4 international infection control and infectious disease conferences. design a cross-sectional study. methods an independent company was commissioned to undertake a twitter 'trawl' each month between july 1, 2016, and november 31, 2016. the trawl identified any tweets that contained the official hashtags of the conferences for (1) the uk infection prevention society, (2) idweek 2016, (3) the federation of ... | 2017 | 28826428 |
| gut microbiota in health, diverticular disease, irritable bowel syndrome, and inflammatory bowel diseases: time for microbial marker of gastrointestinal disorders? | few data exist on differences in gut microbiota composition among principal gastrointestinal (gi) diseases. we evaluated the differences in gut microbiota composition among uncomplicated diverticular disease (dd), irritable bowel syndrome (ibs) and inflammatory bowel diseases (ibd) patients. dd, ibs, and ibd patients along with healthy controls (ct) were enrolled in our italian gi outpatient clinic. stool samples were collected. microbiota composition was evaluated through a metagenomic gene-tar ... | 2017 | 28683448 |
| faecal transplantation for the treatment of clostridium difficile infection in a marmoset. | the common marmoset has been used as an experimental animal for various purposes. because its average weight ranges from 250 to 500 g, weight loss quickly becomes critical for sick animals. therefore, effective and non-stressful treatment for chronic diseases, including diarrhoea, is essential. | 2017 | 28569200 |
| isolation of six novel 7-oxo- or urso-type secondary bile acid-producing bacteria from rat cecal contents. | understanding the dynamics of secondary bile acid (sba) formation in the gut by sba-producing bacteria is important for host health, as sbas have been shown to affect host pathophysiology and gut microbiota composition. however, our knowledge of sba producers is limited in light of the diversity of gut microbes. here, we isolated six novel sba-producing bacteria from rat cecal contents, all of which were members of known species of gut microbes. anaerostipes caccae d10, bacteroides nordii c5, cl ... | 2017 | 28751127 |
| the choice of the anchoring protein influences the interaction of recombinant bacillus spores with the immune system. | the technology of display of heterologous proteins on the surface of bacillus subtilis spores enables use of these structures as carriers of antigens for mucosal vaccination. currently, there are no technical possibilities to predict whether a designed fusion will be efficiently displayed on the spore surface and how such recombinant spores will interact with cells of the immune system. in this study, we compared four variants of b. subtilis spores presenting a fragment of a flid protein from cl ... | 2017 | 28399189 |