Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| bezlotoxumab: a novel agent for the prevention of recurrent clostridium difficile infection. | over the last decade, the incidence and severity of clostridium difficile infection (cdi) have significantly increased, leading to a rise in cdi-associated hospitalizations, health care costs, and mortality. although treatment options exist for cdi, recurrence is frequent following treatment. furthermore, patients with at least one cdi recurrence are at an increased risk of developing additional recurrences. a novel approach to the prevention of recurrent cdi is the use of monoclonal antibodies ... | 2017 | 28730660 |
| clinical characteristics and ultrasonographic findings of acute bacterial enterocolitis in children. | this study clarified the bacterial pathogens currently causing acute infectious enterocolitis (aie) in children and evaluated the clinical characteristics and ultrasonographic findings according to the different pathogens. | 2017 | 28730135 |
| antimicrobial susceptibility of clostridium difficile isolates in israel. | an increase of clostridium difficile isolates with reduced susceptibility to various antimicrobial agents has been observed, including isolates that are non-susceptible to antibiotics that are routinely used for treatment of c. difficile, such as vancomycin and metronidazole. we determined the susceptibility rates of c. difficile isolates from hospitals in northern israel to various antibiotics including tigecycline, which was not previously reported from israel. | 2017 | 28729205 |
| perceptions of clostridium difficile infections among infection control professionals in taiwan. | high clostridium difficile colonization and infection rates among hospitalized patients had been noted in taiwan. nevertheless, the cognition about clinical diagnosis and management of cdi among infection control professionals in taiwan is not clear. | 2017 | 28728905 |
| detection of clostridium difficile antigen and toxin in stool specimens: comparison of the c. difficile quik chek complete enzyme immunoassay and genexpert c. difficile polymerase chain reaction assay. | accurate and rapid laboratory diagnosis of clostridium difficile infections (cdi) remains a significant challenge. a two-step algorithm for detection of toxigenic c. difficile in stool based on initial screening for glutamate dehydrogenase assay followed by confirmation by toxin a+b detection using an enzyme immunoassay (eia) or molecular assay has been proposed. we aimed to evaluate the c. difficile quik chek complete® (qcc-eia) versus the genexpert® c. difficile polymerase chain reaction (pcr) ... | 2017 | 28721981 |
| clinicians should assess the benefits and risks of using bezlotoxumab for reducing the risk of recurrent clostridium difficile infection. | 2017 | 28716810 | |
| gemcitabine associated pseudocellulitis: a missed diagnosis. | we report a case of a 51-year-old male with past medical history significant for cholangiocarcinoma presented with two weeks of worsening bilateral lower extremity swelling and erythema. patient has been on active chemotherapy for his cholangiocarcinoma with gemcitabine weekly infusions. physical exam was significant for bilaterally petechial rash coalescing into ecchymoses over the dorsum of the feet, sparing soles and toes, which dissipated into thinning petechiae more proximally. on labs he d ... | 2017 | 28714381 |
| excess mortality between 2007 and 2014 among patients with clostridium difficile infection: a french health insurance database analysis. | the impact of cdi (clostridium difficile infections) on mortality is controversial. | 2017 | 28712548 |
| vaccines in development for the primary prevention of clostridium difficile infection. | 2017 | 28712463 | |
| multicenter collaboration study on the β-lactam resistant enterobacteriaceae in japan - the 65th anniversary public interest purpose project of the japanese society of chemotherapy. | this study was conducted using the same method of the "1-day multicenter collaborative research for clostridium difficile infectious". this surveillance study was performed by 38 participating medical facilities across japan. of the 268 fecal specimens collected in this study, 5 (1.9%) carbapenem-resistant enterobacteriaceae (cre) were judged carbapenem resistant by the criteria of the infectious disease act, japan (2 mg/l or more and 64 mg/l or more mics for imipenem and cefmetazole, respective ... | 2017 | 28709901 |
| chemical genomics, structure elucidation, and in vivo studies of the marine-derived anticlostridial ecteinamycin. | a polyether antibiotic, ecteinamycin (1), was isolated from a marine actinomadura sp., cultivated from the ascidian ecteinascidia turbinata. (13)c enrichment, high resolution nmr spectroscopy, and molecular modeling enabled elucidation of the structure of 1, which was validated on the basis of comparisons with its recently reported crystal structure. importantly, ecteinamycin demonstrated potent activity against the toxigenic strain of clostridium difficile nap1/b1/027 (mic = 59 ng/μl), as well ... | 2017 | 28708379 |
| systematic review with meta-analysis: the efficacy of faecal microbiota transplantation for the treatment of recurrent and refractory clostridium difficile infection. | clostridium difficile infection (cdi) is the commonest nosocomial cause of diarrhoea. faecal microbiota transplantation (fmt) is an approved treatment for recurrent or refractory cdi but there is uncertainty about its use. | 2017 | 28707337 |
| clostridium difficile, colitis, and colonoscopy: pediatric perspective. | review tests available for detection of clostridium difficile (c. diff) induced disease, including when such tests should be done in children and how they should be interpreted. | 2017 | 28707191 |
| use of a neutralizing antibody helps identify structural features critical for binding of clostridium difficile toxin tcda to the host cell surface. | clostridium difficile is a clinically significant pathogen that causes mild-to-severe (and often recurrent) colon infections. disease symptoms stem from the activities of two large, multi-domain toxins known as tcda and tcdb. the toxins can bind, enter, and perturb host cell function through a multi-step mechanism of receptor binding, endocytosis, pore formation, autoproteolysis, and glucosyltransferase-mediated modification of host substrates. monoclonal antibodies that neutralize toxin activit ... | 2017 | 28705932 |
| prevalence and risk factors for colonization by clostridium difficile and extended-spectrum β-lactamase-producing enterobacteriaceae in rehabilitation clinics in germany. | rehabilitation clinics may vary widely in terms of type of care provided, duration of hospital stay, and case severity. few data are available on prevalence of clostridium difficile or extended-spectrum β-lactamase-producing enterobacteriaceae (esbl-e) colonization in rehabilitation clinics in germany. | 2017 | 28705583 |
| intestinal calcium and bile salts facilitate germination of clostridium difficile spores. | clostridium difficile (c. difficile) is an anaerobic gram-positive pathogen that is the leading cause of nosocomial bacterial infection globally. c. difficile infection (cdi) typically occurs after ingestion of infectious spores by a patient that has been treated with broad-spectrum antibiotics. while cdi is a toxin-mediated disease, transmission and pathogenesis are dependent on the ability to produce viable spores. these spores must become metabolically active (germinate) in order to cause dis ... | 2017 | 28704538 |
| treatment of decubitis ulcer stage iv in the patient with polytrauma and vertical share pelvic fracture, diagnosed entherocollitis and deep wound infection with clostridium difficile with combined negative pressure wound therapy (npwt) and faecal management system: case report. | the aim of this paper was to present a case with the successful treatment of decubitis ulcer stage iv in the patient with polytrauma and vertical share pelvic fracture and diagnosed entherocollitis combined with deep wound infection with clostridium difficile treated with combined negative pressure wound therapy (npwt) and faecal management system. | 2017 | 28698756 |
| high in vitro activity of fidaxomicin against clostridium difficile isolates from a university teaching hospital in china. | clostridium difficile infection (cdi) is a significant cause of morbidity and mortality in both the acute care setting and the wider healthcare system. the purpose of this study was to evaluate the in vitro activity of fidaxomicin against c.difficile isolates from a university teaching hospital in china. | 2017 | 28693926 |
| acquisition of clostridium difficile colonization and infection after transfer from a veterans affairs hospital to an affiliated long-term care facility. | background clostridium difficile infection (cdi) and asymptomatic carriage of toxigenic c. difficile are common in long-term care facilities (ltcfs). however, whether c. difficile is frequently acquired in the ltcf versus during acute-care admissions remains unknown. objective to test the hypothesis that ltcf residents often acquire c. difficile colonization and infection in the ltcf design this 5-month cohort study was conducted to determine the incidence of acquisition of c. difficile coloniza ... | 2017 | 28693636 |
| risk of surgical site infection, acute kidney injury, and clostridium difficile infection following antibiotic prophylaxis with vancomycin plus a beta-lactam versus either drug alone: a national propensity-score-adjusted retrospective cohort study. | the optimal regimen for perioperative antimicrobial prophylaxis is controversial. use of combination prophylaxis with a beta-lactam plus vancomycin is increasing; however, the relative risks and benefits associated with this strategy are unknown. thus, we sought to compare postoperative outcomes following administration of 2 antimicrobials versus a single agent for the prevention of surgical site infections (ssis). potential harms associated with combination regimens, including acute kidney inju ... | 2017 | 28692690 |
| detection of toxigenic clostridium difficile in paediatric patients. | our main objective was a revision of clinical, microbiological and epidemiological results of clostridium difficile-associated infection in paediatric patients (2010-2015). we compared the diagnoses performed by detection of toxins in feces and those performed by real-time pcr. | 2017 | 28689671 |
| room occupancy-associated transmission of mdro, clostridium difficile, or norovirus: results from a room surveillance project. | 2017 | 28689514 | |
| description and validation of a new automated surveillance system for clostridium difficile in denmark. | the surveillance of clostridium difficile (cd) in denmark consists of laboratory based data from departments of clinical microbiology (dcms) sent to the national registry of enteric pathogens (nrep). we validated a new surveillance system for cd based on the danish microbiology database (miba). miba automatically collects microbiological test results from all danish dcms. we built an algorithm to identify positive test results for cd recorded in miba. a cd case was defined as a person with a pos ... | 2017 | 28689506 |
| clostridium difficile infection in contemporary urologic practice. | clostridium difficile infection (cdi) is a high-impact hospital acquired condition and chief driver of excess morbidity, mortality, and treatment cost. diagnosis, treatment, and prevention of clostridium difficile infection is key component of any hospital based practice. urologists see a small percentage of all patients with cdi, however they traditionally utilize antibiotic agents that put patients at risk for cdi. urologic procedures making use of bowel have a significantly higher rate of cdi ... | 2017 | 28688849 |
| adrenal crisis in metastatic breast cancer. | a female patient with oestrogen receptor-positive and human epidermal growth factor receptor 2 (her2)-positive invasive lobular breast cancer presented with progressive disease on ct scan. some days after initiation of antineoplastic chemotherapy and anti-her2 targeted antibody therapy, the patient presented with profuse diarrhoea, neutropaenia, nausea and weakness. although clostridium difficile was rapidly tackled as a causative agent of gastrointestinal complaints, clinical situation did not ... | 2017 | 28687693 |
| prevalence and characteristics of clostridium perfringens and clostridium difficile in dogs and cats attended in diverse veterinary clinics from the madrid region. | despite extensive research on the epidemiology of pathogenic clostridia in dogs and cats, most published studies focus on a selected animal population and/or a single veterinary medical centre. we assessed the burden of clostridium perfringens and c. difficile shedding by small animals in 17 veterinary clinics located within the madrid region (spain) and differing in size, number and features of animals attended and other relevant characteristics. in addition, we studied the genetic diversity an ... | 2017 | 28687280 |
| antimicrobial stewardship approaches in the intensive care unit. | antimicrobial stewardship programs aim to monitor, improve, and measure responsible antibiotic use. the intensive care unit (icu), with its critically ill patients and prevalence of multiple drug-resistant pathogens, presents unique challenges. this article reviews approaches to stewardship with application to the icu, including the value of diagnostics, principles of empirical and definitive therapy, and measures of effectiveness. there is good evidence that antimicrobial stewardship results in ... | 2017 | 28687210 |
| recreational sandboxes for children and dogs can be a source of epidemic ribotypes of clostridium difficile. | different studies have suggested that the sand of public playgrounds could have a role in the transmission of infections, particularly in children. furthermore, free access of pets and other animals to the playgrounds might increase such a risk. we studied the presence of clostridium difficile in 20 pairs of sandboxes for children and dogs located in different playgrounds within the madrid region (spain). clostridium difficile isolation was performed by enrichment and selective culture procedure ... | 2017 | 28686001 |
| present and past perspectives on clostridium difficile infection. | clostridium difficile is a gram-positive bacillus that has become one of the main hospital-acquired human gastrointestinal infections in recent years. its incidence is on the rise, involving more virulent strains, affecting new and previously uncontemplated groups of patients, and producing changes in clinical presentation and treatment response that influence disease outcome. early diagnosis and disease stratification based on the severity of c.difficile infection are essential for therapeutic ... | 2017 | 28684034 |
| vancomycin vs metronidazole for clostridium difficile infection: focus on recurrence and mortality. | 2017 | 28681270 | |
| increasing incidence of clostridium difficile ribotype 001 associated with severe course of the infection and previous fluoroquinolone use in the czech republic, 2015. | the aim of the study was to provide an update on the epidemiology of c. difficile infection (cdi) in a representative number of hospitals within the czech republic in 2015. in 2015, twenty-eight czech hospitals were invited to participate in a cdi study. laboratories sent the first 20 consecutive c. difficile isolates for characterization by capillary-electrophoresis (ce) ribotyping and the presence of toxin genes and collected patient data on previous hospitalization, antibiotic treatment, the ... | 2017 | 28681203 |
| outcome after discontinuation of proton pump inhibitors at a residential care site: quality improvement project. | increased prescribing of proton pump inhibitors (ppis) in the past few decades can be attributed mainly to long-term use of this type of therapy. recent evidence indicates signals of harm associated with long-term use of ppis, such as increased risk of clostridium difficile infection, recurrence of c. difficile infection, and fracture. a few studies have assessed the effectiveness of step-down management of patients receiving long-term ppi therapy in ambulatory care settings. however, it is unkn ... | 2017 | 28680175 |
| cwp2 from clostridium difficile exhibits an extended three domain fold and cell adhesion in vitro. | colonization of the gut by clostridium difficile requires the adhesion of the bacterium to host cells. a range of cell surface located factors have been linked to adhesion including the s-layer protein lmw slp and the related protein cwp66. as well as these proteins, the s-layer of c. difficile may contain many others. one such protein is cwp2. here, we demonstrate the production of a c. difficile strain 630 cwp2 knockout mutant and assess the effect on the bacterium. the mutant results in incre ... | 2017 | 28677344 |
| update on intestinal microbiota in crohn's disease 2017: mechanisms, clinical application, adverse reactions and outlook. | the pathogenesis of cd is complex and it is thought to be associated with the environment, immune, hereditary, microbe and other factors. if the balance between the host and the intestinal microbes in cd patients was broken, immune-inflammatory response of susceptible individuals might be triggered. probiotics could improve the intestinal microbial flora balance and treat human effectively. there are several new mechanisms which might explain the role of probiotics. fecal microbiota transplantat ... | 2017 | 28677158 |