Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| bioactive limonoids from the leaves of azaridachta indica (neem). | eight new limonoids (1-8) and one new phenol glycoside (9), along with six known compounds, were isolated from the leaves of azaridachta indica. the structures of 1-9 were elucidated on the basis of spectroscopic data analysis. compounds isolated were assayed for their cytotoxicity against different cancer cell lines. moreover, their ability to interact with the molecular chaperone hsp90, affecting its biological activity, was tested. | 2014 | 24499352 |
| studies on the acaricidal mechanism of the active components from neem (azadirachta indica) oil against sarcoptes scabiei var. cuniculi. | octadecanoic acid-3,4-tetrahydrofuran diester, isolated from neem (azadirachta indica) oil, exhibited potent acaricidal activity against sarcoptes scabiei var. cuniculi. in this paper, the acaricidal mechanism of octadecanoic acid-3,4-tetrahydrofuran diester against sarcoptes scabiei var. cuniculi was evaluated based on pathologic histology and enzyme activities. the results showed that after compound treatment for 24h at a concentration of 20mg/ml, the lesions of mites were prominent under tran ... | 2014 | 24974121 |
| neemdb: convenient database for neem secondary metabolites. | indian neem tree is known for its pesticidal and medicinal properties for centuries. structure elucidation of large number of secondary metabolites responsible for its diverse properties has been achieved. however, this data is spread over various books, scientific reports and publications and difficult to access. we have compiled and stored structural details of neem metabolites in neemdb, a database which can be easily accessed, queried and downloaded. neemdb would be central in dissipating st ... | 2014 | 24966540 |
| vinegar as a disinfectant of extracted human teeth for dental educational use. | extracted human teeth are routinely used in dentistry to learn technical and preclinical skills. centers for disease control and prevention (cdc) has adopted guidelines for infection control of extracted teeth used for research and teaching, requiring that teeth be sterilized before use. many of the proposed disinfection methods starting from use of formalin, sodium hypochlorite and to autoclaving have their own drawbacks and may not be practical. | 2014 | 24959031 |
| traditional uses of medicinal plants against malarial disease by the tribal communities of lesser himalayas-pakistan. | malaria is among the most prevalent infectious diseases in the developing countries of world. estimated number of annual malaria episodes in pakistan is 1.5 million, but very little is known about medicinal plant species of pakistan, which have great potential against malarial disease. present study was aimed to document medicinal plant species used by the local inhabitants of lesser himalayas-pakistan to treat malaria. | 2014 | 24892831 |
| anti-inflammatory and antinociceptive activities of azadirachtin in mice. | azadirachta indica (meliaceae) extracts have been reported to exhibit anti-inflammatory and antinociceptive properties. however, the activities of azadirachtin, a limonoid and the major bioactive compound found in the extracts, have been poorly investigated in animal models. in the present study, we investigated the effects induced by azadirachtin in experimental models of pain and inflammation in mice. carrageenan-induced paw edema and fibrovascular tissue growth induced by subcutaneous cotton ... | 2014 | 24871207 |
| nimbolide b and nimbic acid b, phytotoxic substances in neem leaves with allelopathic activity. | neem (azadirachta indica) has been widely used as a traditional medicine and several bioactive compounds have been isolated from this species, but to date no potent allelopathic active substance has been reported. therefore, we investigated possible allelopathic property and phytotoxic substances with allelopathic activity in neem. an aqueous methanol extract of neem leaves inhibited the growth of roots and shoots of cress, lettuce, alfalfa, timothy, crabgrass, ryegrass, barnyard grass and jungl ... | 2014 | 24865604 |
| effect of oxidative phytochemicals on nicotine-stressed umnsah/df-1 cell line. | nicotine is a parasympathomimetic alkaloid found in the nightshade family of plants (solanaceae) and is a cholinergic drug. it acts directly by stimulating the nicotinic or muscarinic receptors or indirectly by inhibiting cholinesterase, promoting acetylcholine release, or by other mechanisms. 3% of tobacco or one cigarette yields 1 mg of nicotine. as nicotine enters the body, it disturbs the healthy functioning of the body. in this study, we isolated umnsah/df-1 cell line from gallus gallus. fo ... | 2014 | 24860736 |
| a plant-derived wound therapeutic for cost-effective treatment of post-surgical scalp wounds with exposed bone. | to evaluate efficacy and cost-effectiveness of a plant-derived wound dressing (one), a mixture of hypericum oil (hypericum perforatum l.) and neem oil (azadirachta indica a. juss.), in scalp wounds with exposed bone. | 2014 | 24851844 |
| iron-chelating, free radical scavenging and anti-proliferative activities of azadirachta indica. | excessive production of reactive oxygen species leads to oxidative stress which occurs in various diseases, such as diabetes, cancer, neurodegenerative diseases, and secondary iron overload in thalassemia. antioxidants are compounds that inhibit the oxidative processes and delay or suppress oxidative stress. phytochemicals in herbs are interesting sources of natural antioxidants with cancer preventive properties. the use of natural products is beneficial for the prevention and/or treatment of ox ... | 2014 | 24851563 |
| azadirachta indica mitigates dmba-induced hepatotoxicity: a biochemical and radiometric study. | the hepatoprotective potential of aqueous azadirachta indica leaf extract (aaile) was assessed against dmba-induced hepatotoxicity. dmba (7,12-dimethylbenz[a] anthracene) treatment (40 mg/kg body weight, ip) to male balb/c mice resulted in the derailment of liver function as revealed by extremely slow clearance of 99mtc-mebrofenin from liver, elevated levels of alkaline phosphatase (alp) and alanine transaminase (alt), compared to control group. in addition, elevated micronuclei score and high a ... | 2014 | 24791415 |
| material and tableting properties of azadirachta indica gum with reference to official acacia gum. | this study determined the material and tableting properties of azadirachta indica gum (nmg) relative to acacia gum (aca). the morphological properties were assessed with size and shape factors of aspect ratio, roundness, irregularity and equivalent-circle-diameter. the tableting properties of the gums were determined using compressional characteristics, tensile strength (ts), brittle fracture index (bfi) and crushing-strength-friability/disintegration-time ratio (csfr/dt). the results suggest th ... | 2014 | 24779199 |
| comparative anti-microbial efficacy of azadirachta indica irrigant with standard endodontic irrigants: a preliminary study. | the anti-microbial efficacy of 2.5% sodium hypochlorite (shc) and 0.2% chlorhexidine gluconate were compared with an experimental irrigant formulated from the neem tree, azadirachta indica a. juss. | 2014 | 24778508 |
| protective effect of azadirachta indica a. juss against doxorubicin-induced cardiac toxicity in tumour bearing mice. | doxorubicin (dox) treatment (12 microg/g body weight, once a week for 2 weeks) resulted in a significant decrease in the heart rate along with an increase in qrs, st, and qt intervals. histopathological studies showed cardiomyocyte degeneration, cytoplasmic vacuolation and macrophage infiltration in cardiac tissue. a marked increase in the rate of apoptosis was also observed. an increased oxidative stress was evidenced by significantly higher levels of lipid peroxidation (lpo) and depletion of r ... | 2014 | 24772935 |
| chemopreventive and therapeutic effects of nimbolide in cancer: the underlying mechanisms. | cancer chemoprevention is a strategy taken to block, reverse or retard the multistep process of carcinogenesis, including the blockage of its vital morphogenetic milestones viz. normal-preneoplasia-neoplasia-metastasis. naturally occurring phytochemicals are becoming increasingly popular over synthetic drugs for several reasons, including safety, efficacy and easy availability. nimbolide, a triterpene derived from the leaves and flowers of neem, is widely used in traditional medical practices fo ... | 2014 | 24759803 |
| a rare case of toxic optic neuropathy secondary to consumption of neem oil. | a 35-year-old female was referred to our hospital with bilateral loss of vision of two days duration. she gave history of consumption of about 150 ml of neem oil five days back.examination revealed no perception of light in both eyes. both pupils were dilated and sluggishly reacting to light. her fundus examination showed bilateral hyperemic, edematous discs and also edema extending along the superior and inferior temporal vascular arcade. magnetic resonance imaging (mri) scan showed bilateral p ... | 2014 | 24722271 |
| hepatoprotective activity of the neem-based constituent azadirachtin-a in carbon tetrachloride intoxicated wistar rats. | the aim of this study was to investigate the hepatoprotective role of azadirachtin-a in carbon tetrachloride (ccl4) induced hepatotoxicity in rats. the group allotment for the animals used in the hepatoprotective study included a vehicle treatment group, ccl4 (1 ml · (kg body mass)(-1)) treatment group, silymarin (100 μg · (kg body mass)(-1) · day(-1)) + ccl4 treatment group, and groups treated with different doses of azadirachtin-a (100 or 200 μg · (kg body mass)(-1) · day(-1)) + ccl4. on the 9 ... | 2014 | 24708208 |
| limonoids from azadirachta indica var. siamensis extracts and their cytotoxic and melanogenesis-inhibitory activities. | six new limonoids, 7-benzoyl-17-epinimbocinol (5), 3-acetyl-7-tigloylnimbidinin (8), 1-isovaleroyl-1-detigloylsalanninolide (15), 2,3-dihydro-3α-methoxynimbolide (16), deacetyl-20,21-epoxy-20,22-dihydro-21-deoxyisonimbinolide (26), and deacetyl-20,21,22,23-tetrahydro-20,22-dihydroxy-21,23-dimethoxynimbin (27), along with 28 known limonoids, 1-4, 6, 7, 9-14, 17-25, and 28-34, and two known flavonoids, 35 and 36, have been isolated from the extracts of bark, leaves, roots, and seeds of azadirachta ... | 2014 | 24706622 |
| azadirachta indica modulates electrical properties and type of cell death in ndea-induced hepatic tumors. | tissue electrical conductivity is an important indicator of tissue structure and composition. present study demonstrates modulatory effect of azadirachta indica on the electrical conductivity and cell death in hepatic tumors. hepatic tumors were generated by intraperitoneal injection of n-nitrosodiethylamine (cumulative dose: 200 μg/g body mass) to male balb/c mice. aqueous a. indica leaf extract (aaile) was administered orally at a dosage of 100 μg/g body mass till the termination of experiment ... | 2014 | 24696076 |
| dendrophthoe falcata (l.f) ettingsh (neem mistletoe): a potent bioresource to fabricate silver nanoparticles for anticancer effect against human breast cancer cells (mcf-7). | fabrication of metal nano scale particles through environmentally acceptable greener route has been focused with much interest in the present scenario. in this study aqueous leaf extract of mistletoe dendrophthoe falcata (l.f) ettingsh was successfully employed as a reducing and stabilizing agent to fabricate nanosilver particles (agnps) for biomedical applications. various reactions conditions such as temperature, ph, concentration of metal ion, incubation time and stoichiometric proportion of ... | 2014 | 24681313 |
| side effects of neem oil on the midgut endocrine cells of the green lacewing ceraeochrysa claveri (navás) (neuroptera: chrysopidae). | we described the ultrastructure of ceraeochrysa claveri (navás) midgut endocrine cells in larva, pupa, and adult, and evaluated the side effects of ingested neem oil, a botanical insecticide obtained from the seeds of the neem tree (azadirachta indica), on these cells. during the larval period, c. claveri were fed (ad libitum) diatraea saccharalis (f.) eggs treated with neem oil at concentrations of 0.5%, 1%, or 2%. transmission electron microscopy showed that two subtypes of endocrine cells, na ... | 2014 | 27193522 |
| preclinical evaluation of the supercritical extract of azadirachta indica (neem) leaves in vitro and in vivo on inhibition of prostate cancer tumor growth. | azadirachta indica, commonly known as neem, has gained worldwide prominence because of its medical properties, namely antitumor, antiviral, anti-inflammatory, antihyperglycemic, antifungal, and antibacterial activities. despite these promising results, gaps remain in our understanding of the molecular mechanism of action of neem compounds and their potential for use in clinical trials. we investigated supercritical extract of neem leaves (senl) for the following: molecular targets in vitro, in v ... | 2014 | 24674886 |
| ethanolic neem (azadirachta indica) leaf extract prevents growth of mcf-7 and hela cells and potentiates the therapeutic index of cisplatin. | the present study was designed to gain insight into the antiproliferative activity of ethanolic neem leaves extract (enle) alone or in combination with cisplatin by cell viability assay on human breast (mcf-7) and cervical (hela) cancer cells. nuclear morphological examination and cell cycle analysis were performed to determine the mode of cell death. further, to identify its molecular targets, the expression of genes involved in apoptosis, cell cycle progression, and drug metabolism was analyze ... | 2014 | 24624140 |
| targeting stat3 phosphorylation by neem leaf glycoprotein prevents immune evasion exerted by supraglottic laryngeal tumor induced m2 macrophages. | tumor-associated macrophages (tams) are preferentially m2 skewed and promote tumor growth, angiogenesis, invasion, and/or metastasis. in this study, we have analyzed the in vitro immunomodulatory potential of a non-toxic neem leaf glycoprotein (nlgp) in reprogramming stage iii supraglottic laryngeal tumor cell lysate (sltcl) induced m2 tams to their classical anti-tumor shape (m1). data generated from this study support that nlgp is effective in preventing the sltcl induced generation (cd68(+)cd ... | 2014 | 24607970 |
| effects of neem oil (azadirachta indica a. juss) on the replacement of the midgut epithelium in the lacewing ceraeochrysa claveri during larval-pupal metamorphosis. | larvae of the lacewing ceraeochrysa claveri were fed on eggs of diatraeasaccharalis treated with neem oil at concentrations of 0.5%, 1% and 2% throughout the larval period. pupae obtained from treated larvae were used in the study at five days after the completion of cocoon spinning to investigate the effects of neem oil on the replacement of the midgut epithelium during the larval-pupal transition. we observed that the old larval epithelium was shed into the midgut lumen and transformed into th ... | 2014 | 24560939 |
| neem oil poisoning as a cause of toxic encephalopathy in an infant. | 2014 | 24522945 | |
| ethnopharmacological assessment of medicinal plants used against livestock infections by the people living around indus river. | the present study was aimed to document detailed ethnopharmacological knowledge of medicinal plants against livestock infections of an unexplored remote region of pakistan. semistructured questionnaires were used for data collection. total 43 plants belonging to 26 families were found to be used in ethnoveterinary practices. seeds (29%) were found to be the most frequent plant part used followed by leaves (22%). ethnoveterinary recipes were mostly prepared in the form of decoction and powdering. ... | 2014 | 25544941 |
| hypericum perforatum and neem oil for the management of acute skin toxicity in head and neck cancer patients undergoing radiation or chemo-radiation: a single-arm prospective observational study. | radiation dermatitis is common in patients treated with combined radiotherapy and chemotherapy for head and neck malignancies. its timely and adequate management is of uttermost importance for both oncological outcomes and global quality of life. we prospectively evaluated the role of hypericum perforatum and neem oil (holoil®; rimos srl, mirandola, italy) in the treatment of acute skin toxicity for patients undergoing radiotherapy or chemo-radiotherapy for head and neck cancer. | 2014 | 25544371 |
| in vitro thrombolytic potential of root extracts of four medicinal plants available in bangladesh. | thrombus formation inside the blood vessels obstructs blood flow through the circulatory system leading hypertension, stroke to the heart, anoxia, and so on. thrombolytic drugs are widely used for the management of cerebral venous sinus thrombosis patients, but they have certain limitations. medicinal plants and their components possessing antithrombotic activity have been reported before. however, plants that could be used for thrombolysis has not been reported so far. | 2014 | 25538351 |
| production of cellulolytic enzymes by pleurotus species on lignocellulosic wastes using novel pretreatments. | in the present investigation three species of pleurotus i.e. p. sajor—caju (p1), p. florida (p2) and p. flabellatus (p3) along with two lignocellulosic substrates namely paddy straw and wheat straw were selected for evaluation of production of extracellular cellulolytic enzymes. during the cultivation of three species of pleurotus under in vivo condition, the two lignocellulosic substrates were treated with plants extracts (aqueous extracts of ashoka leaves (a) and neem oil (b)), hot water ... | 2014 | 25535714 |
| production of ligninolytic enzymes by white rot fungi on lignocellulosic wastes using novel pretreatments. | production of extracellular ligninolytic enzymes (laccase and polyphenol oxidase) secreted by three species of white rot fungi (pleurotus florida, p. flabellatus and p. sajor—caju) under in vivo condition was studied on two lignocellulosic substrates i.e., paddy straw and wheat straw. these lignocellulosic substrates were treated with neem (azadirachta indica) oil and ashoka (saraca indica) leaves extract. between the two lignocellulosic substrates, paddy straw pretreated with neem oil sup ... | 2014 | 25535711 |
| in vitro antifilarial activity of azadirachta indica aqueous extract through reactive oxygen species enhancement. | to evaluate an aqueous preparation from the azadirachta indica leaves (aea) against setaria cervi (s. cervi), a model filarial parasite. | 2014 | 25441981 |
| development of bioprocess for the production of laccase by pleurotus ostreatus mtcc 1802 using evolutionary optimization technique. | for cost effective production of laccase enzyme (benzenediol: oxygen oxidoreductase) from p. ostreatus mtcc 1802 through solid sate fermentation, physico-chemical parameters such as temperature (20-35 degrees c), incubation period (9-17 days) and substrate (neem bark and wheat bran, in various ratios, w/w) were optimized first by one parameter at time approach and then obtained optimum conditions were considered as zero level in evolutionary optimization factorial design technique. at statistica ... | 2014 | 25434106 |
| neem leaf glycoprotein prophylaxis transduces immune dependent stop signal for tumor angiogenic switch within tumor microenvironment. | we have reported that prophylactic as well as therapeutic administration of neem leaf glycoprotein (nlgp) induces significant restriction of solid tumor growth in mice. here, we investigate whether the effect of such pretreatment (25µg/mice; weekly, 4 times) benefits regulation of tumor angiogenesis, an obligate factor for tumor progression. we show that nlgp pretreatment results in vascular normalization in melanoma and carcinoma bearing mice along with downregulation of cd31, vegf and vegfr2. ... | 2014 | 25391149 |
| nimbolide targets bcl2 and induces apoptosis in preclinical models of waldenströms macroglobulinemia. | neem leaf extract (nle) has medicinal properties, which have been attributed to its limonoid content. we identified the nle tetranorterpenoid, nimbolide, as being the key limonoid responsible for the cytotoxicity of nle in various preclinical models of human b-lymphocyte cancer. of the models tested, waldenströms macroglobulinemia (wm) cells were most sensitive to nimbolide, undergoing significant mitochondrial mediated apoptosis. notably, nimbolide toxicity was also observed in drug-resistant ( ... | 2014 | 25382610 |
| limonoid and steroidal saponin from azadirachta indica. | a new limonoid, 17-(5-methoxy-2-oxofuran-3-yl)-28-deoxonimbolide (1), and a new c21 steroidal saponin, 2α,4α-dihydroxy-pregn-5-en-16-one-3α-o-d-glucopyranoside (2), together with 11 known compounds were isolated from the methanol extract of the leaves of azadirachta indica. the structures were elucidated by means of spectroscopic analysis and putative biosynthetic origins. all the compounds were evaluated for their antibacterial activities against six bacterial strains. | 2014 | 25381190 |
| effect of two herbal mouthwashes on gingival health of school children. | this study aimed at determining the effect of indigenously prepared neem and mango chewing stick mouthwashes on plaque and gingival indices. a sample of 105 children aged 12-15 years was randomized into three groups, namely neem, mango, and chlorhexidine mouthwash groups. all the children were examined at baseline and gingival and plaque indices were recorded. baseline scores for plaque and gingivitis were fair and moderate, respectively, in all the three groups and there existed no statisticall ... | 2014 | 25379471 |
| the use of an extract of hypericum perforatum and azadirachta indica in a neuropathic patient with advanced diabetic foot. | the successful use of an extract of hypericum flowers (hypericum perforatum) and nimh oil (azadirachta indica; hyperoil) in foot wounds with exposed bone in a patient with bilateral advanced diabetic ulcers, has been reported previously. it was hypothesised that this amelioration was linked with the improved glycaemic control and peripheral microvascular circulation. in this case report, the surprisingly successful outcome of another patient using hyperoil for infection damaged diabetic foot, wi ... | 2014 | 25378221 |
| nimbolide inhibits invasion and migration, and down-regulates upar chemokine gene expression, in two breast cancer cell lines. | breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in women, worldwide. urokinase type plasminogen activator (upa) is a serine protease that is involved in cancer progression, especially invasion and metastasis of breast cancer. nimbolide is a potent cytotoxic limnoid isolated from azadirachta indica. our previous studies have shown that nimbolide elicits pleiotropic effects on breast cancer cells; however, its roles in invasion and migration have not pre ... | 2014 | 25377085 |
| [severe poisoning by plants used for traditional medicine in mayotte]. | the authors describe three cases of severe accidental poisoning by plants used as part of a traditional treatment in mayotte. the established, or suspected, toxicity of thevetia peruviana (yellow oleander), cinchona pubescens (red quinine-tree), melia azaderach (persian lilac, also called china berry) and azadirachta indica (neem), is discussed. the clinical presentation is cardiac (atrioventricular block) and well known for thevetia and cinchona intoxications. neurological signs and multi-organ ... | 2014 | 25301110 |
| critical electrolyte concentration of silk gland chromatin of the sugarcane borer diatraea saccharalis, induced using agrochemicals. | the sugarcane borer diatraea saccharalis is widely known as the main pest of sugarcane crop, causing increased damage to the entire fields. measures to control this pest involve the use of chemicals and biological control with cotesia flavipes wasps. in this study, we evaluated the insecticides fipronil (frontline; 0.0025%), malathion (malatol bio carb; 0.4%), cipermetrina (galgotrin; 10%), and neem oil (natuneem; 100%) and the herbicide nicosulfuron (sanson 40 sc; 100%) in the posterior region ... | 2014 | 25299111 |
| [peculicidal activity of plant essential oils and their based preparations]. | the peculicidal activity of eight plant essential oils in 75% isopropyl alcohol was in vitro investigated. of them, the substances that were most active against lice were tea tree (melaleuca), eucalyptus, neem, citronella (cymbopogon nardus), and clove (syzygium aromaticum) oils; kt50 was not more than 3 minutes on average; kt95 was 4 minutes. after evaporating the solvent, only five (tea tree, cassia, clove, anise (anisum vulgare), and japanese star anise (illicium anisatum) oils) of the eight ... | 2014 | 25296426 |
| immunotherapeutic targeting of established sarcoma in swiss mice by tumor-derived antigen-pulsed nlgp matured dendritic cells is cd8+ t-cell dependent. | neem leaf glycoprotein (nlgp) matures human myeloid and mouse bone marrow-derived dendritic cells (dcs). (nlgp) also therapeutically restricts the mouse established sarcoma growth by activating cd8(+) t cells along with increased proportion of tumor residing cd11c(+) dcs. here, we intended to find out whether cd8(+) t cells become cytotoxic to sarcoma cells after presentation of sarcoma antigen by nlgp-matured dcs to restrict murine sarcoma growth. | 2014 | 25290415 |
| biogenic gold nano-triangles: cargos for anticancer drug delivery. | we present synthesis of biogenic gold nano triangles (gnts) using azadirachta indica leaf extract at inherent ph (5.89) and its application in efficient drug delivery of doxorubicin (dox) (anticancer drug). the main idea was to take advantage of large surface area of gnts which has 3 dimensions and use the plant peptides coated on these triangles as natural linkers for the attachment of dox. sucrose density gradient centrifugation (sdgc) and dialysis methods were used for separation of the gnt f ... | 2014 | 25280684 |
| effect of aqueous extract of azadirachta indica a. juss (neem) leaf on oocyte maturation, oviposition, reproductive potentials and embryonic development of a freshwater fish ectoparasite argulus bengalensis ramakrishna, 1951 (crustacea: branchiura). | in present study, a microcosm experiment is carried out to investigate the efficacy of 120 and 250-ppm crude aqueous extract of azadirachta leaf on oocyte maturation, oviposition, embryonic development and hatching of the eggs of a fish ectoparasite argulus bengalensis. relative abundance of different maturing oocyte stages in the ovary of the parasite from different age groups was enumerated, and marked variations were obtained. significant depletion in the abundance of pre-vitollogenic, vitell ... | 2014 | 25270235 |
| expedient preparative isolation and tandem mass spectrometric characterization of c-seco triterpenoids from neem oil. | c-seco triterpenoids are widely bioactive class of natural products with high structural complexity and diversity. the preparative isolation of these molecules with high purity is greatly desirable, although restricted due to the complexity of natural extracts. in this article we have demonstrated a medium pressure liquid chromatography (mplc) based protocol for the isolation of eight major c-seco triterpenoids of salannin skeleton from neem (azadirachta indica) oil. successive application of no ... | 2014 | 25267707 |
| 10be climate fingerprints during the eemian in the neem ice core, greenland. | several deep greenland ice cores have been retrieved, however, capturing the eemian period has been problematic due to stratigraphic disturbances in the ice. the new greenland deep ice core from the neem site (77.45 °n, 51.06 °w, 2450 m.a.s.l) recovered a relatively complete eemian record. here we discuss the cosmogenic (10)be isotope record from this core. the results show eemian average (10)be concentrations about 0.7 times lower than in the holocene which suggests a warmer climate and approxi ... | 2014 | 25266953 |
| botanicals, selective insecticides, and predators to control diaphorina citri (hemiptera: liviidae) in citrus orchards. | the asian citrus psyllid (acp) diaphorina citri kuwayama vectors pathogens that cause huanglongbing (hlb) or citrus greening devastating and economically important disease present in most citrus growing regions. young citrus shoots are required for psyllid reproduction and development. during winter citrus trees produce little or no new growth. overwintering adults reproduce in spring on newly emerging shoots also attractive to other pests and beneficial insects. botanicals and relatively select ... | 2014 | 25205398 |
| characteristics of tomato plants treated with leaf extracts of neem (azadirachta indica a. juss. (l.)) and mata-raton (gliricidia sepium (jacquin)): a greenhouse experiment. | extracts of neem (azadirachta indica a.) and mata-raton (gliricidia sepium) leaves were used as insect repellent during organic cultivation of tomato plants (solanum lycopersicum) and were compared with untreated plants or plants treated with lambda-cyhalothrin (chemical treatment). the best developed tomato plants were found in the gliricidia treatment, while difference between other treatments were small. the number of different species of macrofauna found on tomato plants were similar in diff ... | 2014 | 25204070 |
| a monoclonal antibody against neem leaf glycoprotein recognizes carcinoembryonic antigen (cea) and restricts cea expressing tumor growth. | carcinoembryonic antigen (cea) is one of the promising tumor antigens mainly associated with carcinoma of the colon, lung, breast, etc. and received wide attention for cancer immunotherapy. neem leaf glycoprotein (nlgp), an effective immunomodulator, is able to generate humoral and cellular immune responses in murine tumor models. we have generated a monoclonal antibody (mab) against nlgp by fusing nlgp-immunized mice splenocytes with nonsecretory myeloma cells. a highly anti-nlgp mab secreting ... | 2014 | 25198527 |
| neem (azadirachta indica l.) leaf extract deteriorates oocyte quality by inducing ros-mediated apoptosis in mammals. | neem (azadirachta indica l.) leaf has been widely used in ayurvedic system of medicine for fertility regulation for a long time. the molecular mechanism by which neem leaf regulates female fertility remains poorly understood. animal studies suggest that aqueous neem leaf extract (nle) induces reactive oxygen species (ros) - mediated granulosa cell apoptosis. granulosa cell apoptosis deprives oocytes from nutrients, survival factors and cell cycle proteins required for the achievement of meiotic ... | 2014 | 25197620 |
| azadirachta indica attenuates cisplatin-induced nephrotoxicity and oxidative stress. | we investigated the effects of methanolic leaves extract of azadirachta indica (mlen, 500 mg/kg bwt) on cisplatin- (cp-) induced nephrotoxicity and oxidative stress in rats. cp (5 mg/kg bwt) was injected intraperitoneally and mlen was given by gastric gavage for 5 days before or after cp injection. after 5 days of cp injection, cp-induced injury of the renal tissue was evidenced (i) as histopathological damage of the renal tissue, (ii) as increases in serum uric acid, urea, and creatinine, (iii) ... | 2014 | 25162019 |
| apoptosis-inducing effect of three medicinal plants on oral cancer cells kb and orl-48. | brucea javanica, azadirachta indica, and typhonium flagelliforme are medicinal plants commonly used to treat conditions associated with tumour formation. this study aimed to determine the antiproliferative activity of these plants extracts on kb and orl-48 oral cancer cell lines and to suggest their mode of cell death. the concentration producing 50% cell inhibition (ic50) was determined and the activity was examined under an inverted microscope. immunohistochemistry fluorescent staining method ... | 2014 | 25147833 |
| comparative immunomodulation potential of tinospora cordifolia (willd.) miers ex hook. f., tinospora sinensis (lour.) merrill and tinospora cordifolia growing on azadirachta indica a. juss. | guduchi has been widely used in the traditional medicine as an immunomodulator. description of guduchi in ayurvedic literature resemble with t. sinensis rather than with commonly available t. cordifolia and hence this may be used as substitutes for t. sinensis. t. cordifolia growing on azadirachta indica commonly called neem-guduchi has more immunomodulatory potential. thus, immunomodulatory activity of three tinospora spp. was assessed by checking humoral and cell mediated immune responses to t ... | 2014 | 25141544 |
| management of mango hopper, idioscopus clypealis, using chemical insecticides and neem oil. | an experiment was conducted in field laboratory, department of entomology at bangladesh agricultural university, mymensingh, during 2013 to manage the mango hopper, idioscopus clypealis l, using three chemical insecticides, imidacloprid (0.3%), endosulfan (0.5%), and cypermethrin (0.4%), and natural neem oil (3%) with three replications of each. all the treatments were significantly effective in managing mango hopper in comparison to the control. imidacloprid showed the highest efficacy in perce ... | 2014 | 25140344 |
| morphological alterations in the synganglion and integument of rhipicephalus sanguineus ticks exposed to aqueous extracts of neem leaves (azadirachta indica a. juss). | currently, the necessity of controlling infestation by ticks, especially by rhipicephalus sanguineus, has led researchers and public health managers around the world to search for new and more efficient control methods. this way, we can highlight neem (azadirachta indica a. juss) leaf, bark, and seed extracts, which have been very effective on tick control, and moreover causing less damage to the environment and to the host. this study showed the potential of neem as a control method for r. sang ... | 2014 | 25130979 |
| murine carcinoma expressing carcinoembryonic antigen-like protein is restricted by antibody against neem leaf glycoprotein. | we have generated a polyclonal antibody against a novel immunomodulator, neem leaf glycoprotein (nlgp) that can react to a specific 47 kda subunit of nlgp. generated anti-nlgp antibody (primarily igg2a) was tested for its anti-tumor activity in murine carcinoma (ec, ct-26), sarcoma (s180) and melanoma (b16mel) tumor models. surprisingly, tumor growth restriction was only observed in ct-26 carcinoma models, without any alteration in other tumor systems. comparative examination of antigenicity bet ... | 2014 | 25128841 |
| investigation of total phenolic content and antioxidant activities of azadirachta indica roots. | the present study was an attempt to study total phenolic content and antioxidant property of the crude ethanolic extract of the roots of azadirachta indica (a. indica). | 2014 | 25050306 |
| peltate glandular trichomes of colquhounia seguinii harbor new defensive clerodane diterpenoids. | glandular trichomes produce a wide variety of secondary metabolites that are considered as major defensive chemicals against herbivore attack. the morphology and secondary metabolites of the peltate glandular trichomes of a lianoid labiatae, colquhounia seguinii vaniot, were investigated. three new clerodane diterpenoids, seguiniilactones a-c (1-3), were identified through precise trichome collection with laser microdissection, metabolic analysis with ultra performance liquid chromatography-tand ... | 2014 | 25048077 |
| three new and other limonoids from the hexane extract of melia azedarach fruits and their cytotoxic activities. | a defatted fraction obtained from the hexane extract of the fruits of melia azedarach l. (chinaberry tree; meliaceae) exhibited cytotoxic activities against leukemia (hl60), lung (a549), stomach (az521), and breast (sk-br-3) cancer cell lines with ic50 values in the range of 2.9-21.9 μg/ml. three new limonoids, 3-deacetyl-4'-demethylsalannin (5), 3-deacetyl-28-oxosalannin (14), and 1-detigloylohchinolal (17), along with 16 known limonoids, 1-4, 6-13, 15, 16, 18, and 19, and one known triterpenoi ... | 2014 | 25044585 |
| multi-constituent synergism is responsible for anti-inflammatory effect of azadirachta indica leaf extract. | azadirachta indica a. juss. (meliaceaes) leaves have been used traditionally to treat swelling and rheumatism in indian cultures. | 2014 | 25026347 |
| beneficial effect of azadirachta indica on advanced glycation end-product in streptozotocin-diabetic rat. | both oxidation and hyperglycemia cause increased glycation and the formation of advanced glycation end-products (ages) which underlie the complications of diabetes. | 2014 | 25026338 |
| neem components as potential agents for cancer prevention and treatment. | azadirachta indica, also known as neem, is commonly found in many semi-tropical and tropical countries including india, pakistan, and bangladesh. the components extracted from neem plant have been used in traditional medicine for the cure of multiple diseases including cancer for centuries. the extracts of seeds, leaves, flowers, and fruits of neem have consistently shown chemopreventive and antitumor effects in different types of cancer. azadirachtin and nimbolide are among the few bioactive co ... | 2014 | 25016141 |
| solubility and bioavailability enhancement of poorly aqueous soluble atorvastatin: in vitro, ex vivo, and in vivo studies. | the objective of this investigation was to improve the solubility of the poorly water soluble drug atorvastatin (atr), using solid dispersion (sd) techniques, with neem gum (ng) as a hydrophilic carrier. the effects of the polymer concentration and method of preparation on the solubility and dissolution rate were studied. the results showed that the solubility of atr increases with increasing ng concentration. however, dissolution rate of atr from its sd was dependent on the method used to prepa ... | 2014 | 24995297 |
| bait spray for control of european cherry fruit fly: an appraisal based on semi-field and field studies. | the european cherry fruit fly, rhagoletis cerasi, is the major insect pest of sweet and tart cherries. its management is becoming increasingly difficult in many countries as formerly effective but broad-spectrum insecticides are removed from the market. with the objective of identifying suitable and environmentally safe alternatives, we investigated bait sprays containing two families of plant-derived insecticides: azadirachtins (neemazal-t(®) and neemazal-t/s(®) ) and pyrethrins (spruzit neu(®) ... | 2014 | 23893955 |
| development of a sensitive hptlc method for quantification of nimbolide in azadirachta indica and its dosage form. | an improved and sensitive high performance thin-layer chromatography (hptlc) method has been developed for determination of anticancer compound, nimbolide in different parts of azadirachta indica and its dosage form. a quick and simple ultrasonication technique was used for the preparation of sample solutions. separation of the components was achieved on precoated tlc plates by using optimized tertiary mobile phase consisting of n-hexane:ethyl acetate:acetic acid (6:4:0.2, v/v/v) with a solvent ... | 2014 | 24108814 |
| triterpenoids from the fruits of azadirachta indica (meliaceae). | four new triterpenoids, indicalilacols a-d (1-4), were isolated from the meoh extract of the fruits of azadirachta indica, including a new 19(10→9β)abeo-tirucallane derivative, two new tirucallane-type triterpenoids, and a new euphane-type triterpenoid, along with three known tirucallane-type triterpenoids. their structures were elucidated on the basis of spectroscopic analyses. the absolute configuration of 2 was elucidated by the chemical conversion of 2 into 21-oxo-melianodiol 24,25-acetonide ... | 2014 | 24239747 |
| anti-proliferative and apoptosis inducing effect of nimbolide by altering molecules involved in apoptosis and igf signalling via pi3k/akt in prostate cancer (pc-3) cell line. | prostate cancer is responsible for major deaths globally after lung cancer. nimbolide is an important constituent of neem, and it acts as a potent inhibitor for many cancer cells. the present study was designed to evaluate the effects of nimbolide on apoptosis and insulin-like growth factor (igf) signalling molecules in androgen-independent prostate cancer (pc-3) cells line. nimbolide (0.5-2 μm) treatment resulted in 50% inhibition at a dose of 2 μm in the pc-3 cell line. the mrna expression of ... | 2014 | 23963693 |
| direct inhibition of retinoblastoma phosphorylation by nimbolide causes cell-cycle arrest and suppresses glioblastoma growth. | classical pharmacology allows the use and development of conventional phytomedicine faster and more economically than conventional drugs. this approach should be tested for their efficacy in terms of complementarity and disease control. the purpose of this study was to determine the molecular mechanisms by which nimbolide, a triterpenoid found in the well-known medicinal plant azadirachta indica, controls glioblastoma growth. | 2014 | 24170547 |
| neem leaf extract inhibits mammary carcinogenesis by altering cell proliferation, apoptosis, and angiogenesis. | plant-based medicines are useful in the treatment of cancer. many breast cancer patients use complementary and alternative medicine in parallel with conventional treatments. neem is historically well known in asia and africa as a versatile medicinal plant with a wide spectrum of biological activities. the experiments reported herein determined whether the administration of an ethanolic fraction of neem leaf (efnl) inhibits progression of chemical carcinogen-induced mammary tumorigenesis in rat m ... | 2014 | 24146019 |
| antifilarial effects of polyphenol rich ethanolic extract from the leaves of azadirachta indica through molecular and biochemical approaches describing reactive oxygen species (ros) mediated apoptosis of setaria cervi. | lymphatic filariasis, a global cause of morbidity needs much more attention in developing potent therapeutics that can be effective against both microfilariae (mf) and adults. efficient botanicals that can induce apoptosis of filarial parasites possibly can provide a direction towards developing new class of antifilarials. in this work we have evaluated the antifilarial efficacy of an optimized polyphenol rich ethanolic extract of azadirachta indica leaves (eea). a. indica a. juss has been widel ... | 2014 | 24275557 |
| expression of pro-inflammatory interleukin-8 is reduced by ayurvedic decoctions. | eleven decoctions, obtained from indian plants widely used in ayurvedic medicine, have been investigated as a possible source of molecules exhibiting biological activity on the interaction between dna and nf-kb, a transcription factor involved in the expression of proinflammatory genes. cystic fibrosis (cf) cell line stimulated by tnf-α has been used as inflammatory cellular model to determinate interleukin-8 (il-8), one of the most relevant pro-inflammatory mediator in cf regulated by the nf-kb ... | 2014 | 24395450 |
| in vitro and in vivo effects of neem tree (azadirachta indica a. juss) products on larvae of the sheep nose bot fly (oestrus ovis l. díptera: oestridae). | two studies were carried out in order to test the effects of neem tree extracts (azadirachta indica a. juss) on sheep bot fly larvae (oestrus ovis l. diptera: oestridae). first, aqueous extracts from neem seeds (asne) at 0, 5 y 10% (w/v) concentrations were tested on larval mortality in vitro. in a second study, the effect of oral administration with neem seed meal (0, 100 y 200mg/kg) and neem leaves (1% of diet) on number of larvae found at necropsy and larval development was evaluated in exper ... | 2014 | 24332964 |
| neem limonoids as anticancer agents: modulation of cancer hallmarks and oncogenic signaling. | neem (azadirachta indica a. juss) is one of the most versatile medicinal plants, widely distributed in the indian subcontinent. neem is a rich source of limonoids that are endowed with potent medicinal properties predominantly antioxidant, anti-inflammatory, and anticancer activities. azadirachtin, gedunin, and nimbolide are more extensively investigated relative to other neem limonoids. accumulating evidence indicates that the anticancer effects of neem limonoids are mediated through the inhibi ... | 2014 | 27102702 |
| comparative studies on performance characteristics of ci engine fuelled with neem methyl ester and mahua methyl ester and its respective blends with diesel fuel. | in the present investigation, neem and mahua methyl ester were prepared by transesterification using potassium hydroxide as a catalyst and tested in 4-stroke single cylinder water cooled diesel engine. tests were carried out at constant speed of 1500 rev/min at different brake mean effective pressures. a series of tests were conducted which worked at different brake mean effective pressures, okpa, 1kpa, 2kpa, 3kpa, 4kpa, 5kpa, 6kpa and 6.5kpa. the performance and exhaust emission characteristics ... | 2014 | 26445759 |
| neem: unusually versatile plant genus azadirachta with many useful and so far insufficiently exploited properties for agriculture, medicine, and industry. | neem plants (rutales: meliaceae) are well known for their multitude of human benefits in various fields. specifically well investigated are the indian neem tree azadirachta indica a. juss., the thai neem a. siamensis val., the originally malaysian/philippinean neem a. excelsa (jack) and, as a close relative, the persian lilac, melia azedarach. the major and most active natural products are azadirachtin, salannin, nimbin and marrangin from azadirachta species, and azadirachtin analogues like meli ... | 2014 | 26084100 |
| neem leaf extract induces cell death by apoptosis and autophagy in b-chronic lymphocytic leukemia cells. | chronic lymphocytic leukemia (cll) is the most common adult leukemia and is currently incurable. to expand the therapeutic armamentarium, we investigated neem leaf extract (nle) after a patient with cll demonstrated disease regression upon taking oral nle. nle-mediated apoptosis was examined in peripheral blood mononuclear cells (pbmcs) from 41 patients with cll. nle induced a dose-dependent reduction in cll cell viability with significant apoptosis observed at 0.06% (w/v) by 24 h. annexin-v sta ... | 2014 | 23721511 |
| development of microbial resistant thermosensitive ag nanocomposite (gelatin) hydrogels via green process. | in this investigation, an ecofriendly method for the synthesis of silver nanoparticles (agnps) using biodegradable gelatin as a stabilizing agent is reported. here, we prepared thermosensitive silver nanocomposite hydrogels composed of gelatin and n-isopropylacrylamide. in this green process agnps were formed from ag(+) ions and reduced with leaf [azadirachta indica (neem leaf)] extracts, resulting in a hydrogel network. the ag(0) nanoparticles affect the hydrogel strength and improved the biolo ... | 2014 | 23650266 |
| in-vivo and in-vitro activities of medicinal plants on ecto, endo and haemoparasitic infections: a review. | crude methanol, pet. ether, ethyl acetate, n-hexane, dichloromethane and aqueous extracts of various species of medicinal plants have shown significant in-vivo and in-vitro pharmacological activities against ecto, endo and haemoparasites. the scientific evaluations of the use of the plants as antiparasitic agents were based on the claims of folklore drawn from traditional healers from various communities across the world. the pharmacological activities of these plants were associated with the pr ... | 2014 | 23173971 |
| silver nanoparticles: a possibility for malarial and filarial vector control technology. | green synthesis technology is one of the rapid, reliable and best routes for the synthesis of silver nanoparticles (agnps). there are bioactive compounds with enormous potential in azadirachta indica (neem). the extraordinary mosquitoes warrant nanotechnology to integrate with novel molecules. this will be sustainable technology for future. here, we synthesized agnps using aqueous extracts of leaves and bark of az. indica (neem). we tested agnps as larvicides, pupicides and adulticides against t ... | 2014 | 25132567 |
| storage behavior of mango as affected by post harvest application of plant extracts and storage conditions. | the use of plant extracts could be a useful alternative to synthetic fungicides in the post harvest handling of fruits and vegetables. the aim of this study was to access the efficacy of extracts obtained from four plants (neem, pongamia, custard apple leaf and marigold flowers) on the extension of shelf life of mango fruits cv. dashehri under two storage conditions (cool store and ambient condition). the fruits were treated with 2 concentrations of each plant extracts (10 % and 20 %) were place ... | 2014 | 25328189 |
| efficacy and insecticidal properties of some essential oils against caryedon serratus (oliver)-a storage pest of groundnut. | during storage groundnut is attacked by number of stored grain pest and management of these insect pests particularly bruchid beetle, caryedon serratus (oliver) is of prime importance as they directly damage the pod and kernels. hence, some essential oils were tested for their insecticidal and fungicidal properties. highest total bruchid mortality was recorded with the application of neem oil and pongamia oil at 10% (v/w) concentration and lowest in eucalyptus oil at 5% (v/w). number of eggs lai ... | 2014 | 26396354 |
| a comparative study on the decomposition of edible and non-edible oil cakes in the gangetic alluvial soil of west bengal. | an experiment has been conducted under laboratory conditions to investigate the effect of decomposition of two edible oil cakes, viz. mustard cake (brassica juncea l) and groundnut cake (arachis hypogaea l), and two non-edible oil cakes, viz. mahua cake (madhuca indica gmel) and neem cake (azadirachta indica juss), at the rate of 5.0 t ha(-1) on the changes of microbial growth and activities in relation to transformations and availability of some plant nutrients in the gangetic alluvial (typic h ... | 2014 | 24733437 |
| feeding deterrence of cabbage looper (lepidoptera: noctuidae) by 1-allyloxy-4-propoxybenzene, alone and blended with neem extract. | the cabbage looper, trichoplusia ni (hübner) (lepidoptera: noctuidae), is one of the most damaging insect pests of cabbage (brassica oleracea variety capitata) and broccoli (b. oleracea variety italica) in north america. leaf-feeding larvae attack crucifer and vegetable crops in greenhouses and fields. here, we have studied a synthetic feeding deterrent, 1-allyloxy-4-propoxybenzene, and a botanical deterrent, neem (an extract from seeds of azadirachta indica a. de jussieu (meliaceae)), in leaf d ... | 2014 | 26470077 |
| comparative anti-inflammatory effects of anti-arthritic herbal medicines and ibuprofen. | non-steroidal anti-inflammatory drugs (nsaids), such as ibuprofen, are widely used over-the-counter drugs to treat arthritis, but they are often associated with side effects. herbal medicines have been used to treat various diseases such as arthritis, but the scientific profiles are not well understood. in this study, we examined, in comparison with ibuprofen, the inhibitory effects on various inflammatory markers of the most commonly used herbal medicines to treat arthritis, boswellia (boswelli ... | 2014 | 25918809 |
| review on molecular and chemopreventive potential of nimbolide in cancer. | cancer is the most dreaded disease in human and also major health problem worldwide. despite its high occurrence, the exact molecular mechanisms of the development and progression are not fully understood. the existing cancer therapy based on allopathic medicine is expensive, exhibits side effects; and may also alter the normal functioning of genes. thus, a non-toxic and effective mode of treatment is needed to control cancer development and progression. some medicinal plants offer a safe, effec ... | 2014 | 25705153 |
| yield loss assessment due to alternaria blight and its management in linseed. | field experiments were conducted during 2010-11 and 2011-12 to assess the yield losses due to alternaria blight disease caused by alternaria lini and a. linicola in recently released cultivars and their management with the integration of trichoderma viride, fungicides and plant extract. disease severity on leaves varied from 41.07% (parvati) to 65.01% (chambal) while bud damage per cent ranged between 23.56% (shekhar) to 46.12% (t-397), respectively in different cultivars. maximum yield loss of ... | 2014 | 25911838 |
| field evaluation of a botanical formulation from the milky mangrove excoecaria agallocha l. against helicoverpa armigera hübner. in abelmoschus esculentus (lady's finger) and cajanus cajan (pigeon pea). | to evaluate a formulation from the milky mangrove tree excoecaria agallocha l. (e. agallocha) against helicoverpa armigera hubner (h. armigera). | 2014 | 25312115 |
| an ethnobotanical study of indigenous knowledge on medicinal plants used by the village peoples of thoppampatti, dindigul district, tamilnadu, india. | this study provides significant ethnopharmacological information, both qualitative and quantitative on medicinal plants in the thoppampatti village, dindigul district, tamilnadu, india. there is urgency in recording such data to conserve the traditional medicinal plants. this is the first ethnobotanical study which records the traditional important medicinal plants of thoppampatti village. to collect, analyze and evaluate the ethnopharmacologic knowledge in thoppampatti village in order to prote ... | 2014 | 24583241 |
| antibacterial activity of aqueous extracts of indian chewing sticks on dental plaque: an in vitro study. | the anti-microbial efficacy of aqueous extracts of indian chewing sticks against different kinds of plaque bacteria in vitro was investigated. supra-gingival plaque is cultured and subjected to the antibacterial activity of the aqueous extracts of chewing sticks (neem, acacia, pongamia glabra, achyranthes aspera, streblus asper) separately. the results of the study demonstrate that all the five chewing sticks under study possess inhibitory potential against bacteria present in dental plaque main ... | 2014 | 25210357 |
| [nutrient accumulation and cycling in pure and mixed plantations of azadirachta indica and acacia auriculiformis in a dry-hot valley, yunnan province, southwest china]. | to ease the implementation of effective nutrient management for plantations with different vegetation restoration patterns and to assist in the selection of appropriate species and forestation patterns, nutrient (n, p, k, ca and mg) accumulation and cycling were investigated and compared in three plantations (10-year-old azadirachta indica, acacia auriculiformis and mixed a. indica--a. auriculiformis plantations) in yuanmou valley, a dry-hot valley of yunnan province, southwestern china. the res ... | 2014 | 25345036 |
| studies on repellent activity of seed oils alone and in combination on mosquito, aedes aegypti. | the study was undertaken to investigate the relative repellency of pongamia pinnata and azadirachta indica seed oils on vector mosquito, aedes aegypti under laboratory conditions. the repellents were formulated into 3 groups: seed oils, their mixture and combination of seed oils with three carrier oils viz. olive, mustard and coconut oil. different formulations of each oil were tested at the concentrations of 1% and 5% on human baits. efficiency was assessed, based on the total protection time; ... | 2014 | 25204067 |
| effect of azadirachta indica (neem) and aloe vera as compared to subantimicrobial dose doxycycline on matrix metalloproteinases (mmp)-2 and mmp-9: an in-vitro study. | a critical outcome of periodontal diseases is degradation of collagen in the periodontal tissues, by enzymes such as matrix metallo-proteinases (mmps). doxycycline is known to down-regulate the activity of mmps. azadirachta indica (neem) and aloe vera are herbs known to have an anti-inflammatory effect. the present study was designed to evaluate the anti-inflammatory effect of neem and aloe vera by way of its inhibitory effect on mmp-2 and mmp-9 activity in cases of chronic periodontitis and com ... | 2014 | 25364206 |
| ethnomedicinal plants used to treat skin diseases by tharu community of district udham singh nagar, uttarakhand, india. | tharu community is the largest primitive indigenous community of the uttarakhand, india. in this article we have scientifically enumerated medicinal plants and herbal preparations used by the tharu community to treat various skin diseases, and discussed dermatological properties of these plants in the light of previous ethnomedicinal, microbiological, pharmacological, toxicological, phytochemical and clinical studies. | 2014 | 25448505 |
| acaricidal effect of herbal extracts against cattle tick rhipicephalus (boophilus) microplus using in vitro studies. | the crude methanolic extract of datura stramonium, azadirachta indica, and calotropis procera leaves, allium sativum (as) cloves, and carica papaya (cp) seeds collected from banaskanta, gujarat (india) was tested for its acaricidal properties against rhipicephalus (boophilus) microplus. the percent adult mortality within 15 days, reproductive index, percentage inhibition of oviposition, hatching of laid ova, and percentage larval mortality were studied at concentrations of 12.5, 25, 50, and 100 ... | 2014 | 24633906 |
| shedding light on bioactivity of botanical by-products: neem cake compounds deter oviposition of the arbovirus vector aedes albopictus (diptera: culicidae) in the field. | industrial plant-borne by-products can be sources of low-cost chemicals, potentially useful to build eco-friendly control strategies against mosquitoes. neem cake is a cheap by-product of neem oil extraction obtained by pressing the seeds of azadirachta indica. neem products are widely used as insecticides since rarely induce resistance because their multiple mode of action against insect pests and low-toxicity rates have been detected against vertebrates. in this research, we used field bioassa ... | 2014 | 24337544 |
| useful ethnophytomedicinal recipes of angiosperms used against diabetes in south east asian countries (india, pakistan & sri lanka). | this paper is based on data recorded from various literatures pertaining to ethnophytomedicinal recipes used against diabetes in south east asia (india, pakistan and srilanka). traditional plant treatments have been used throughout the world for the therapy of diabetes mellitus. in total 419 useful phytorecipes of 270 plant species belonging to 74 angiospermic families were collected. from the review it was revealed that plants showing hypoglycemic potential mainly belong to the families, cucurb ... | 2014 | 25176368 |
| the antimicrobial activity of azadirachta indica, mimusops elengi, tinospora cardifolia, ocimum sanctum and 2% chlorhexidine gluconate on common endodontic pathogens: an in vitro study. | to check the antimicrobial activity of azadirachta indica (neem), ocimum sanctum (tulsi), mimusops elelngi (bakul), tinospora cardifolia (giloy) and chlorhexidine gluconate (chx) on common endodontic pathogens like streptococcus mutans, enterococcus faecalis and staphylococcus aureus. | 2014 | 24966766 |
| antibacterial and antiviral evaluation of sulfonoquinovosyldiacylglyceride: a glycolipid isolated from azadirachta indica leaves. | assessment of antibacterial as well as antiherpes virus activity of sulfonoquinovosyldiacylglyceride (sqdg), a glycolipid, isolated from the leaves of azadirachta indica has been described. antimicrobial activity was evaluated against gram-positive, gram-negative bacteria and herpes simplex virus. sqdg showed significant inhibitory activity against salmonella typhi and two isolates of shigella dysenteriae with mic values 32 μg ml(-1) , while three isolates of salm. typhi, escherichia coli and vi ... | 2014 | 24118020 |
| in vitro bioactivity and antimicrobial tuning of bioactive glass nanoparticles added with neem (azadirachta indica) leaf powder. | silica and phosphate based bioactive glass nanoparticles (58sio2-33cao-9p2o5) with doping of neem (azadirachta indica) leaf powder and silver nanoparticles were prepared and characterised. bioactive glass nanoparticles were produced using sol-gel technique. in vitro bioactivity of the prepared samples was investigated using simulated body fluid. x-ray diffraction (xrd) pattern of prepared glass particles reveals amorphous phase and spherical morphology with a particle size of less than 50 nm. wh ... | 2014 | 25276834 |