Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| impact of aging on trem-1 responses in the periodontium: a cross-sectional study in an elderly population. | aging is associated with altered immune response, which increases susceptibility to infections. strem-1 is involved in the amplification of the inflammatory response to bacterial infection. the present cross-sectional study aims to investigate local strem-1 levels in gingival crevicular fluid (gcf) as well as key periodontal pathogen levels in the subgingival plaque in an elderly cohort with periodontal health, gingivitis, and chronic periodontitis (cp). | 2016 | 27542376 |
| periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in b10.riii mice. | it has been previously hypothesized that oral microbes may be an etiological link between rheumatoid arthritis (ra) and periodontal disease. however, the mechanistic basis of this association is incompletely understood. here, we investigated the role of periodontal bacteria in induction of joint inflammation in collagen-induced arthritis (cia) in b10.riii mice. | 2016 | 27405639 |
| putative periodontopathic bacteria and herpesviruses in pregnant women: a case-control study. | little is known about herpesvirus and putative periodontopathic bacteria in maternal chronic periodontitis. the present case-control study aimed to explore the potential relationship between putative periodontopathic bacteria and herpesviruses in maternal chronic periodontitis.saliva samples were collected from 36 pregnant women with chronic periodontitis (cases) and 36 pregnant women with healthy periodontal status (controls). six putative periodontopathic bacteria (porphyromonas gingivalis [pg ... | 2016 | 27301874 |
| adjunctive use of essential oils following scaling and root planing -a randomized clinical trial. | hitherto no study has been published on the effect of the adjunctive administration of essential oils following scaling and root planing (srp). this study describes the effect of a mouthrinse consisting of essential oils (cymbopogon flexuosus, thymus zygis and rosmarinus officinalis) following srp by clinical and microbiological variables in patients with generalized moderate chronic periodontitis. | 2016 | 27266517 |
| quantitative molecular detection of 19 major pathogens in the interdental biofilm of periodontally healthy young adults. | in oral health, the interdental spaces are a real ecological niche for which the body has few or no alternative defenses and where the traditional daily methods for control by disrupting biofilm are not adequate. the interdental spaces are the source of many hypotheses regarding their potential associations with and/or causes of cardiovascular disease, diabetes, chronic kidney disease, degenerative disease, and depression. this pcr study is the first to describe the interdental microbiota in hea ... | 2016 | 27313576 |
| frequency of periodontal pathogens and helicobacter pylori in the mouths and stomachs of obese individuals submitted to bariatric surgery: a cross-sectional study. | this cross-sectional study compared the frequency of oral periodontopathogens and h. pylori in the mouths and stomachs of obese individuals with or without periodontitis submitted to bariatric surgery. | 2016 | 27383704 |
| differential responses of pattern recognition receptors to outer membrane vesicles of three periodontal pathogens. | highly purified outer membrane vesicles (omvs) of the periodontal pathogens, porphyromonas gingivalis, treponema denticola and tannerella forsythia were produced using tangential flow ultrafiltration, ultracentrifugation and optiprep density gradient separation. cryo-tem and light scattering showed omvs to be single lipid-bilayers with modal diameters of 75 to 158 nm. enumeration of omvs by nanoparticle flow-cytometry at the same stage of late exponential culture indicated that p. gingivalis was ... | 2016 | 27035339 |
| microbiological efficacy of photodynamic therapy as an adjunct to non-surgical periodontal treatment: a clinical trial. | the efficiency of routine scaling and root planning is negatively influenced by the tooth anatomy and residual bacteria all possibly affecting the treatment outcomes in future. the present study compared the microbiologic effectiveness of the photodynamic therapy (pdt) as an adjunctive treatment modality for nonsurgical treatment in chronic periodontitis. | 2016 | 27330709 |
| comparison of the efficacy of subgingival irrigation with 2% povidone-iodine and tetracycline hcl in subjects with chronic moderate periodontitis: a clinico microbiological study. | this study was performed to evaluate and compare the clinical and antimicrobial efficacy of subgingival irrigation with tetracycline and povidone-iodine as an adjunct to nonsurgical periodontal therapy. | 2016 | 27076823 |
| microbiological and clinical effects of sitafloxacin and azithromycin in periodontitis patients receiving supportive periodontal therapy. | sitafloxacin (stfx) is a newly developed quinolone that has robust antimicrobial activity against periodontopathic bacteria. we previously reported that oral administration of stfx during supportive periodontal therapy was as effective as conventional mechanical debridement under local anesthesia microbiologically and clinically for 3 months. the aim of the present study was to examine the short-term and long-term microbiological and clinical effects of systemic stfx and azithromycin (azm) on ac ... | 2016 | 26729495 |
| surface interactions between two of the main periodontal pathogens: porphyromonas gingivalis and tannerella forsythia. | porphyromonas gingivalis and tannerella forsythia have been implicated as the major etiologic agents of periodontal disease. these two bacteria are frequently isolated together from the periodontal lesion, and it has been suggested that their interaction may increase each one's virulence potential. the purpose of this study was to identify proteins on the surface of these organisms that are involved in interbacterial binding. | 2016 | 26937289 |
| interleukin-17a gene variability in patients with type 1 diabetes mellitus and chronic periodontitis: its correlation with il-17 levels and the occurrence of periodontopathic bacteria. | interleukin-17 contributes to the pathogenesis of type 1 diabetes mellitus (t1dm) and chronic periodontitis (cp). we analyzed il-17a -197a/g and il-17f +7488c/t polymorphisms in t1dm and cp and determined their associations with il-17 production and occurrence of periopathogens. totally 154 controls, 125 t1dm, and 244 cp patients were genotyped using 5' nuclease taqman(®) assays. bacterial colonization was investigated by a dna-microarray kit. production of il-17 after in vitro stimulation of mo ... | 2016 | 26924897 |
| identification of ompa-like protein of tannerella forsythia as an o-linked glycoprotein and its binding capability to lectins. | bacterial glycoproteins are associated with physiological and pathogenic functions of bacteria. it remains unclear whether bacterial glycoproteins can bind to specific classes of lectins expressed on host cells. tannerella forsythia is a gram-negative oral anaerobe that contributes to the development of periodontitis. in this study, we aimed to find lectin-binding glycoproteins in t. forsythia. we performed affinity chromatography of wheat germ agglutinin, which binds to n-acetylglucosamine (glc ... | 2016 | 27711121 |
| identification of microorganisms in biofluids of individuals with periodontitis and chronic kidney disease using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. | chronic kidney disease (ckd) and periodontitis (pd) are important health issues. there is a large variety of microorganisms related to the pathogenesis of periodontitis, and optimising the time and the cost of laboratory assays to detect these organisms is highly valuable in the medical field. | 2016 | 28328023 |
| microbial dynamics during conversion from supragingival to subgingival biofilms in an in vitro model. | the development of dental caries and periodontal diseases result from distinct shifts in the microbiota of the tooth-associated biofilm. this in vitro study aimed to investigate changes in biofilm composition and structure, during the shift from a 'supragingival' aerobic profile to a 'subgingival' anaerobic profile. biofilms consisting of actinomyces oris, candida albicans, fusobacterium nucleatum, streptococcus oralis, streptococcus mutans and veillonella dispar were aerobically grown in saliva ... | 2016 | 26033167 |
| generalized aggressive periodontitis: microbiological composition and clinical parameters in non-surgical therapy. | the aim of this study was to determine the variations in periodontal parameters and microbiological composition in periodontal pockets at the baseline and 3 and 6 months post treatmentin patients with generalized aggressive periodontitis(gap) undergoing non surgical periodontal treatment combined with chlorhexidine and systemic antibiotics. medical and dental history was taken from 10 subjects, average age 30.6±2.7 years, diagnosed with gap. a non surgical periodontal treatment combined with 0.1 ... | 2016 | 28383606 |
| detection of subgingival periodontal pathogens--comparison of two sampling strategies. | the aim of the study is to compare detection frequency of periodontal pathogens in patients with aggressive/severe chronic periodontitis using pooled plaque samples from the deepest pockets per quadrant/per sextant. | 2016 | 26193958 |
| investigation of the oral status and microorganisms in children with phenylketonuria and type 1 diabetes. | the aim of this study was to investigate the oral parameters that influence the caries risk and risk of developing periodontal disease in children with phenylketonuria (pku) and type 1 diabetes compared to healthy children. | 2016 | 26297129 |
| changes in salivary periodontal pathogens after orthodontic treatment: an in vivo prospective study. | to analyze the initial changes in salivary levels of periodontal pathogens after orthodontic treatment with fixed appliances. | 2016 | 26606331 |
| oral microbiota, periodontal status, and osteoporosis in postmenopausal females. | alterations in hormone levels during menopause decrease bone density and may worsen oral health, favoring the growth of periodontal pathogens, whose detection could improve the diagnosis of periodontitis. the aim of this study is to detect and quantify the main periodontal pathogens in the oral microbiota of postmenopausal females and to explore the relationship between clinical and periodontal parameters. | 2016 | 26469811 |
| protein biomarkers and microbial profiles in peri-implantitis. | the aim of the present investigation was to determine the profile of peri-implant crevicular fluid (picf) biomarkers combined with microbial profiles from implants with healthy peri-implant tissues and peri-implantitis to assess real-time disease activity. | 2016 | 26424287 |
| does obesity influence the subgingival microbiota composition in periodontal health and disease? | to evaluate whether obesity affects the subgingival microbial composition of patients with periodontal health or chronic periodontitis (cp). | 2016 | 27717180 |
| association of porphyromonas gingivalis with high levels of stress-induced hormone cortisol in chronic periodontitis patients. | the aim of the present study was to evaluate the association between the occurrence of periodontopathogens with cortisol levels in chronic periodontitis patients. | 2016 | 26194628 |
| periodontal surgery involving modified widman flap procedure and connective tissue graft for generalized aggressive periodontitis: a case report. | we report a case of generalized aggressive periodontitis (agp) requiring periodontal treatment including flap surgery and ridge augmentation. the patient was a 39-year-old woman who presented with the chief complaint of pus discharge from tooth #36. no other obvious signs of gingival inflammation were observed. periodontal examination revealed multiple sites with a probing depth of ≥10 mm. radiography showed pro-nounced bone defects in the maxillary incisors and molar region. real-time pcr was u ... | 2016 | 28049974 |
| effect of resveratrol on periodontal pathogens during experimental periodontitis in rats. | the objective of this study was to investigate the antibacterial effect of resveratrol against putative periodontal pathogens during the progression of experimental periodontitis in rats. periodontitis was induced in rats in one of the first molars chosen to receive a ligature. animals were assigned to one of two groups: daily administration of the placebo solution (control group, n = 12) or 10 mg/kg of resveratrol (resv group, n = 12). the therapies were administered systemically for 30 days, f ... | 2016 | 27901209 |
| prevalence of periodontal pathogens as predictor of the evolution of periodontal status. | the aim of this study was to determine the relationship between the prevalence of porphyromonas gingivalis, its fima genotypes, aggregatibacter actinomycetemcomitans, tannerella forsythia, and treponema denticola and the evolution of periodontal health. in a longitudinal prospective study, samples of subgingival plaque were taken from 114 patients (37 with chronic periodontitis, 17 with gingivitis, and 60 periodontally healthy) in the course of a full periodontal examination. pcr was employed to ... | 2016 | 27888369 |
| periodontal and microbiological profile of intensive care unit inpatients. | the bidirectional relationship between the periodontal diseases and systemic diseases was attributed to the focal infection concept. the aims of this study were to assess the periodontal and microbiological profile of intensive care unit (icu) inpatients submitted to orotracheal intubation, and classify them regarding gender, age group, ethnic, hospitalization reason and period, nosocomial infection occurrence, and death. | 2016 | 27794150 |
| changes in salivary periodontal pathogens after orthodontic treatment: an in vivo prospective study. | to analyze the initial changes in salivary levels of periodontal pathogens after orthodontic treatment with fixed appliances. | 2016 | 27792427 |
| the distribution of porphyromonas gingivalis, tannerella forsythia, treponema denticola and aggregatibacter actinomycetemcomitans in patients with alcoholic disease: a pilot study. | both drinking and periodontal disease are serious health and social problems. findings on the effect of alcohol consumption on periodontal disease are inconclusive. | 2016 | 27627556 |
| adhesion of periodontal pathogens to self-ligating orthodontic brackets: an in-vivo prospective study. | our aims were to analyze adhesion of periodontopathogens to self-ligating brackets (clarity-sl [csl], clippy-c [cc] and damon q [dq]) and to identify the relationships between bacterial adhesion and oral hygiene indexes. | 2016 | 27585775 |
| d-galactose as an autoinducer 2 inhibitor to control the biofilm formation of periodontopathogens. | autoinducer 2 (ai-2) is a quorum sensing molecule to which bacteria respond to regulate various phenotypes, including virulence and biofilm formation. ai-2 plays an important role in the formation of a subgingival biofilm composed mostly of gram-negative anaerobes, by which periodontitis is initiated. the aim of this study was to evaluate d-galactose as an inhibitor of ai-2 activity and thus of the biofilm formation of periodontopathogens. in a search for an ai-2 receptor of fusobacterium nuclea ... | 2016 | 27572513 |
| prevalence of periodontopathogens and candida spp. in smokers after nonsurgical periodontal therapy - a pilot study. | this pilot study aimed to evaluate the influence of smoking on clinical and microbiological parameters after nonsurgical periodontal therapy. forty-eight subjects were grouped into smokers (sm, n = 24) and nonsmokers (ns, n = 24) and paired according to gender, age, ethnicity, and periodontal status. both groups received oral hygiene education and scaling and root planing. clinical evaluation was performed using plaque index (pi), bleeding on probing (bop), pocket probing depth (ppd), gingival r ... | 2016 | 27556680 |
| longitudinal study on clinical and microbial analysis of periodontal status in pregnancy. | this study was aimed to provide a longitudinal overview of the subgingival bacterial microbiome using fluorescence in situ hybridization (fish) technique, in women in the second trimester of pregnancy (between 14 and 24 weeks), and 48 h and 8 weeks postpartum. of 31 women evaluated during pregnancy, 24 returned for the 48-h and 18 for their 8-week exams postpartum. probing depth (pd), bleeding on probing, clinical attachment level, and presence of calculus were recorded. subgingival plaque sampl ... | 2016 | 27556678 |
| bacterial load of periodontal pathogens among italian patients with chronic periodontitis: a comparative study of three different areas. | the aim of the present study was to evaluate the mean bacterial load of some periodontal pathogenic bacteria in italian patients affected by chronic periodontitis. the sample consisted of 1,762 patients with a clinical diagnosis of chronic periodontitis based on the criteria of the american academy of periodontology sampled in the period 2013-2015; 1,323 patients were from northern italy, 317 from central italy and 122 from southern italy. samples for microbiological analysis were collected from ... | 2016 | 27469562 |
| evaluation of the efficacy of a new oral gel containing carvacrol and thymol for home oral care in the management of chronic periodontitis using pcr analysis: a microbiological pilot study. | the use of chemical devices for domestic oral hygiene in periodontal patients has led to new treatment strategies aiming primarily at a control of infection. over the last few years, carvacrol and thymol (ct) have been subjected to many scientific and medical studies. the purpose of the present study was to assess the effect of ct on the red complex bacteria using polymerase chain reaction (pcr) for microbiological analysis. five patients with a diagnosis of chronic periodontitis in the age grou ... | 2016 | 27469559 |
| periodontopathogens antibodies and major adverse events following an acute myocardial infarction: results from the french registry of acute st-elevation and non-st-elevation myocardial infarction (fast-mi). | periodontopathogens antibodies have been shown to be associated with primary myocardial events, but little is known regarding their impact on major adverse events after a prior acute myocardial infarction (ami). the present prospective study evaluates the association between antibody levels of 4 periodontopathogens and the risk of all-cause death or non-fatal myocardial infarction (mi) at 1 year in 975 patients admitted for acute st segment or non-st segment elevation mi in french registry of ac ... | 2016 | 27325868 |
| adjunct antimicrobial therapy and periodontal surgery to treat generalized aggressive periodontitis: a case report. | here we report a case of generalized aggressive periodontitis treated with periodontal therapy including adjunct antimicrobial therapy and periodontal surgery. the patient was a 22-year-old woman who presented with the chief complaint of gingival recession. baseline examination revealed generalized plaque deposition and gingival inflammation. thirty-nine percent of the sites had a probing depth (pd) of 4-6 mm and 2% a pd of ≥7 mm; 63% exhibited bleeding on probing (bop). radiographic examination ... | 2016 | 27320300 |
| microbiological distribution of six periodontal pathogens between untreated italian and dutch periodontal patients. | to compare prevalence and microbial load of six periodontal pathogens between italian and dutch patients affected by chronic periodontitis, using oligonucleotide probe technology. | 2016 | 26870849 |
| oral and endotracheal tubes colonization by periodontal bacteria: a case-control icu study. | periodontal infection is a possible risk factor for respiratory disorders; however, no studies have assessed the colonization of periodontal pathogens in endotracheal tubes (et). this case-control study analyzed whether periodontal pathogens are able to colonize et of dentate and edentulous patients in intensive care units (icu) and whether oral and et periodontal pathogen profiles have any correlation between these patients. we selected 18 dentate and 18 edentulous patients from 78 eligible icu ... | 2016 | 26810057 |
| cytokine and microbial profiles in relation to the clinical outcome following treatment of peri-implantitis. | to study whether cytokine levels and bacterial counts in p atients with peri-implantitis reflect clinical treatment outcome following non-surgical management. | 2016 | 27422156 |
| full mouth periodontal debridement with or without adjunctive metronidazole gel in smoking patients with chronic periodontitis: a pilot study. | the evidence of effectiveness of metronidazole (mtz) as an adjunct therapy to periodontal procedure in the treatment of patients with chronic periodontitis is not conclusive. the aim of this study was to compare the effect of mtz (delivered locally as a gel or systemically as a tablet) as an adjunctive therapy with full mouth periodontal debridement (1 h of ultrasonic calculus/plaque removal) in smokers with chronic periodontitis. | 2016 | 25900347 |
| analysis of p. gingivalis, t. forsythia and s. aureus levels in edentulous mouths prior to and 6 months after placement of one-piece zirconia and titanium implants. | it has been suggested that completely edentulous patients harbour fewer periodontopathic bacteria compared with dentate patients, due to the removal of the subgingival periodontal environment. however, reappearance of certain microbes has been reported after the placement of implants in these patients. | 2016 | 25529603 |
| gingipain-dependent augmentation by porphyromonas gingivalis of phagocytosis of tannerella forsythia. | in the pathogenesis of periodontitis, porphyromonas gingivalis plays a role as a keystone pathogen that manipulates host immune responses leading to dysbiotic oral microbial communities. arg-gingipains (rgpa and rgpb) and lys-gingipain (kgp) are responsible for the majority of bacterial proteolytic activity and play essential roles in bacterial virulence. therefore, gingipains are often considered as therapeutic targets. this study investigated the role of gingipains in the modulation by p. ging ... | 2016 | 26434368 |
| impact of heavy smoking on the clinical, microbiological and immunological parameters of patients with dental implants: a prospective cross-sectional study. | the aim of the present study was to investigate how heavy smoking influences the clinical, microbiological, and host-response characteristics in peri-implant sulcus fluid of patients with healthy dental implants. | 2016 | 26171870 |
| periodontitis contributes to adipose tissue inflammation through the nf-<kappa>b, jnk and erk pathways to promote insulin resistance in a rat model. | this study aimed to investigate the mechanism by which periodontitis affects the inflammatory response and systemic insulin resistance in the white adipose and liver tissues in an obese rat model. the obese model was generated by feeding rats a high fat diet. the periodontitis model was induced by ligatures and injection of "red complex", which consisted of porphyromonas gingivalis, treponema denticola, and tannerella forsythia, for two weeks. when compared with rats without periodontitis, fasti ... | 2016 | 27565999 |
| lysine-specific proteolytic activity responsible for forsythia detaching factor modification. | the objective of the present study was to clarify the lysine-specific proteolytic activity derived from periodontal pathogens responsible for forsythia detaching factor (fdf) modification. | 2016 | 27399273 |
| [gender-related marker pathogens of periodontal disease in chronic periodontitis]. | by using qpcr system, women as well as men were found to have an equal periodontal pathogen colonization. however, the women are subjected to have a higher risk of chronic periodontitis onsets. women with the chronic periodontitis usually expose an evident hypercolonization with a single pathogen. p. gingivalis is the most prevalent causative agent of the chronic periodontitis in women but not in men. in health as well as in the chronic periodontitis a complex of periodontal pathogens forms such ... | 2016 | 27367192 |
| head and neck intensity modulated radiation therapy leads to an increase of opportunistic oral pathogens. | the introduction of intensity modulated radiation therapy (imrt) has led to new possibilities in the treatment of head and neck cancer (hnc). limited information is available on how this more advanced radiation technique affects the oral microflora. in a prospective study we assessed the effects of various advanced treatments for hnc on the oral microflora, as well as the effects of elimination of oral foci of infection. | 2016 | 27311400 |
| the influences of periodontal status and periodontal pathogen quantity on salivary 8-hydroxydeoxyguanosine and interleukin-17 levels. | periodontitis is a biofilm-initiated disease that is characterized by elevated inflammatory status. 8-hydroxydeoxyguanosine (8-ohdg) and interleukin (il)-17 are highly associated with inflammation and bone resorption and therefore are regarded as potential biomarkers for periodontitis. in this study, the associations between salivary 8-ohdg and il-17 levels and clinical and microbial parameters before and after non-surgical treatment are investigated. | 2016 | 26654345 |
| bacterial interactions in pathogenic subgingival plaque. | chronic periodontitis has a polymicrobial biofilm aetiology. polymicrobial biofilms are complex, dynamic microbial communities formed by two or more bacterial species that are important for the persistence and proliferation of participating microbes in the environment. interspecies adherence, which often involves bacterial surface-associated molecules, and communications are essential in the spatial and temporal development of a polymicrobial biofilm, which in turn is necessary for the overall f ... | 2016 | 26541672 |
| polymicrobial infection alter inflammatory microrna in rat salivary glands during periodontal disease. | periodontal disease initiated by subgingival pathogens is linked with diminished secretion of saliva, and implies pathogenic bacteria dissemination to or affects secondary sites such as the salivary glands. micrornas activated in response to bacteria may modulate immune responses against pathogens. therefore, sprague-dawley rats were infected by oral lavage consisting of polymicrobial inocula, namely porphyromonas gingivalis, tannerella forsythia, and treponema denticola, or sham-infected for 12 ... | 2016 | 26481834 |
| association between maternal periodontitis and preterm and/or low birth weight infants in normal pregnancies. | to relate the periodontal condition with the presence of periodontal bacteria in pregnant that had babies with preterm delivery or/and low weight at birth (ptlbw). | 2016 | 25394610 |
| 24-hour evaluation of dental plaque bacteria and halitosis after consumption of a single placebo or dental treat by dogs. | objective to determine whether consumption of a single dental treat with specific mechanical properties and active ingredients would provide a 24-hour effect on dental plaque bacteria and halitosis in dogs. animals 10 dogs of various breeds from a privately owned colony that had received routine dental scaling and polishing 4 weeks before the study began. procedures dogs were randomly assigned to receive 1 placebo or dental treat first. a 4-week washout period was provided, and then dogs receive ... | 2016 | 27227499 |
| global tlr2 and 4 deficiency in mice impacts bone resorption, inflammatory markers and atherosclerosis to polymicrobial infection. | toll-like-receptors (tlrs) play a significant role in the generation of a specific innate immune response against invading pathogens. tlr2 and tlr4 signaling contributes to infection-induced inflammation in periodontal disease (pd) and atherosclerosis. observational studies point towards a relationship between pd and atherosclerosis, but the role of tlr2 and tlr4 in the recognition of multiple oral pathogens and their modulation of host response leading to atherosclerosis are not clear. we evalu ... | 2016 | 27224005 |
| microbial colonization of the peri-implant sulcus and implant connection of implants restored with cemented versus screw-retained superstructures: a cross-sectional study. | the aim of this study is to investigate peri-implant and intraconnection microflora of healthy implants restored with cemented and screwed superstructures. | 2016 | 27153291 |
| sialic acid transporter nant participates in tannerella forsythia biofilm formation and survival on epithelial cells. | tannerella forsythia is a periodontal pathogen implicated in periodontitis. this gram-negative pathogen depends on exogenous peptidoglycan amino sugar n-acetylmuramic acid (nam) for growth. in the biofilm state the bacterium can utilize sialic acid (neu5ac) instead of nam to sustain its growth. thus, the sialic acid utilization system of the bacterium plays a critical role in the growth and survival of the organism in the absence of nam. we sought the function of a t. forsythia gene annotated as ... | 2016 | 26318875 |
| consequences of orthodontic treatment in malocclusion patients: clinical and microbial effects in adults and children. | malocclusion is a common disease of oral and maxillofacial region. the study was aimed to investigate levels changes of periodontal pathogens in malocclusion patients before, during and after orthodontic treatments, and to confirm the difference between adults and children. | 2016 | 27793138 |
| bacteria prevalence in a large italian population sample: a clinical and microbiological study. | the present study detects those bacterial species which are more strongly related to bleeding on probing, suppuration and smoking in periodontal-affected patients. nine hundred and fifty-one patients with periodontal diseases were admitted to the department of periodontology and implantology, dental school of bologna university where they underwent microbiological tests for six periodontal pathogens (actinomyces actinomycetemcomitans, porphyromonas gingivalis, prevotella intermedia, treponema de ... | 2016 | 27469569 |
| impact of implant-abutment connection on osteoimmunological and microbiological parameters in short implants: a randomized controlled clinical trial. | the study aimed to determine the levels of soluble receptor activator of nuclear factor-кb ligand (srankl) and osteoprotegerin (opg) as well as their relative calculated ratio in peri-implant crevicular fluid (picf) obtained around two different types of implant-abutment connection on short implants following a 12-month monitoring period. moreover, the levels of a number of oral bacterial species were investigated in the corresponding submucosal biofilm samples. | 2016 | 27469171 |
| non-oral gram-negative facultative rods in chronic periodontitis microbiota. | the subgingival prevalence of gram-negative facultative rods not usually inhabiting or indigenous to the oral cavity (non-oral gnfr), as well as selected periodontal bacterial pathogens, were evaluated by culture in untreated and treated chronic periodontitis patients. | 2016 | 26835659 |
| association of clinical parameters with periodontal bacterial haemolytic activity. | to determine whether haemolytic activity of subgingival bacteria is associated with periodontitis clinical parameters and to identify which bacteria produce the haemolysins. | 2016 | 27105613 |
| combinations of bacterial species associated with symptomatic endodontic infections in a chinese population. | to use microarrays to detect 11 selected bacteria in infected root canals, revealing bacterial combinations that are associated with clinical symptoms and signs of primary endodontic infections in a chinese population. | 2016 | 25565631 |
| evaluation of efficacy of photodynamic therapy as an adjunct to nonsurgical periodontal therapy in treatment of chronic periodontitis patients: a clinico-microbiological study. | photodynamic therapy (pdt) is a local noninvasive treatment modality without side effects caused by antibiotics. the aim of this study was to evaluate the efficacy of adjunctive use of pdt with scaling and root planing as compared with srp alone in the treatment of chronic periodontitis. | 2016 | 27966504 |
| first cultivation of health-associated tannerella sp. hot-286 (bu063). | despite significant advances in recent years in culture-independent molecular microbiology methods, the detailed study of individual bacterial species still relies on having pure cultures in the laboratory. yet, more than a third of the approximately 700 bacterial taxa found in the human oral cavity are as yet uncultivated in vitro. one such taxon, tannerella sp. hot-286 (phylotype bu063), is the focus of much interest since it is associated with periodontal health, while tannerella forsythia, i ... | 2016 | 27193146 |
| microbiota at teeth and implants in partially edentulous patients. a 10-year retrospective study. | to determine the microbiota at implants and adjacent teeth 10 years after placement of implants with a sandblasted and acid-etched surface. | 2016 | 25827437 |
| influence of the periodontal status on the initial-biofilm formation on titanium surfaces. | dental implants will be exposed to a complex ecosystem once they are placed in the oral cavity. the bacterial colonization and biofilm formation on these devices will depend not only on the physicochemical surface implant properties but also on the periodontal health conditions of the patients, as these devices are exposed. | 2016 | 24995517 |
| the current weight of evidence of the microbiologic profile associated with peri-implantitis: a systematic review. | there is currently no consensus regarding microorganisms that may be considered true peri-implant pathogens. therefore, the aim of this systematic review is to determine the weight of evidence for microorganisms related to peri-implantitis based on results of association studies. | 2016 | 27420109 |
| periodontal pathogens and risk of incident cancer in postmenopausal females: the buffalo osteoperio study. | extraoral translocation of oral bacteria may contribute to associations between periodontal disease and cancer. the associations among the presence of three orange-complex periodontal pathogens (fusobacterium nucleatum, prevotella intermedia, and campylobacter rectus), two red-complex periodontal pathogens (porphyromonas gingivalis and tannerella forsythia), and cancer risk were investigated. | 2016 | 26513268 |
| identification of a novel n-acetylmuramic acid transporter in tannerella forsythia. | tannerella forsythia is a gram-negative periodontal pathogen lacking the ability to undergo de novo synthesis of amino sugars n-acetylmuramic acid (murnac) and n-acetylglucosamine (glcnac) that form the disaccharide repeating unit of the peptidoglycan backbone. t. forsythia relies on the uptake of these sugars from the environment, which is so far unexplored. here, we identified a novel transporter system of t. forsythia involved in the uptake of murnac across the inner membrane and characterize ... | 2016 | 27601356 |
| in vitro resistance testing of porphyromonas gingivalis, prevotella intermedia, and tannerella forsythia to triclosan. | to determine the sensitivity of porphyromonas gingivalis, prevotella intermedia, and tannerella forsythia to triclosan, and determine if these bacteria develop resistance to triclosan upon prolonged exposure. | 2016 | 27340161 |
| levels of candidate periodontal pathogens in subgingival biofilm. | in recent years, several new periodontal taxa have been associated with the etiology of periodontitis. a recent systematic review provides further support for the pathogenic role of 17 species/phylotypes. thus, the aim of this study was to assess the prevalence and levels of these species in subjects with generalized chronic periodontitis (gchp; n = 30), generalized aggressive periodontitis (gagp; n = 30), and periodontal health (ph; n = 30). all subjects underwent clinical and microbiological a ... | 2016 | 26936213 |
| structure of ragb, a major immunodominant outer-membrane surface receptor antigen of porphyromonas gingivalis. | porphyromonas gingivalis is the main causative agent of periodontitis. it deregulates the inflammatory and innate host immune responses through virulence factors, which include the immunodominant outer-membrane surface receptor antigens a (pgraga) and b (pgragb), co-transcribed from the rag pathogenicity island. the former is predicted to be a ton-dependent porin-type translocator but the targets of this translocation and the molecular function of pgragb are unknown. phenomenologically, pgragb h ... | 2016 | 26441291 |
| tlr4, nod1 and nod2 mediate immune recognition of putative newly identified periodontal pathogens. | periodontitis is a polymicrobial inflammatory disease that results from the interaction between the oral microbiota and the host immunity. although the innate immune response is important for disease initiation and progression, the innate immune receptors that recognize both classical and putative periodontal pathogens that elicit an immune response have not been elucidated. by using the human oral microbe identification microarray (homim), we identified multiple predominant oral bacterial speci ... | 2016 | 26177212 |
| pathogenic potential of tannerella forsythia enolase. | although enolases are cytosolic enzymes involved in the glycolytic pathway, they can also be secreted or expressed on the surface of a variety of eukaryotic cells and bacteria. surface-exposed enolases of eukaryotes and bacteria can function as plasminogen receptors. furthermore, antibodies raised against bacterial enolases can react with host enolases, suggesting molecular mimicry between bacterial and host enzymes. in this study, we analyzed an enolase of the major periodontopathogen tannerell ... | 2016 | 26172848 |
| mirolysin, a lysarginase from tannerella forsythia, proteolytically inactivates the human cathelicidin, ll-37. | tannerella forsythia is a periodontal pathogen expressing six secretory proteolytic enzymes with a unique multidomain structure referred to as klikk proteases. two of these proteases, karilysin and mirolysin, were previously shown to protect the bacterium against complement-mediated bactericidal activity. the latter metalloprotease, however, was not characterized at the protein level. therefore, we purified recombinant mirolysin and subjected it to detailed biochemical characterization. mirolysi ... | 2016 | 27997347 |
| draft genome sequences of three clinical isolates of tannerella forsythia isolated from subgingival plaque from periodontitis patients in the united states. | we report the genome sequences of three clinical isolates of tannerella forsythia from the subgingival plaque of periodontitis patients attending clinics at the school of dental medicine, university at buffalo. the availability of these genome sequences will aid the understanding of the pathogenesis of periodontitis. | 2016 | 27908987 |
| identification and characterization of a chymotrypsin-like serine protease from periodontal pathogen, tannerella forsythia. | tannerella forsythia is a bacteria associated with severe periodontal disease. this study reports identification and characterization of a membrane-associated serine protease from t. forsythia. the protease was isolated from t. forsythia membrane fractions and shown to cleave both gelatin and type i collagen. the protease was able to cleave both substrates over a wide range of ph values, however optimal cleavage occurred at ph 7.5 for gelatin and 8.0 for type i collagen. the protease was also sh ... | 2016 | 27594668 |
| tannerella forsythia groel induces inflammatory bone resorption and synergizes with interleukin-17. | tannerella forsythia is a major periodontal pathogen, and t. forsythia groel is a molecular chaperone homologous to human heat-shock protein 60. interleukin-17 (il-17) has been implicated in the pathogenesis of periodontitis and several systemic diseases. this study investigated the potential of t. forsythia groel to induce inflammatory bone resorption and examined the cooperative effect of il-17 and t. forsythia groel on inflammatory responses. human gingival fibroblasts (hgfs) and periodontal ... | 2016 | 27484636 |
| impact of rare diseases in oral health. | rare diseases (rd) are those that present a lower prevalence than 5 cases per 10.000 population. the main objective of this review was to study the effect on oral health in rare diseases, while the secondary objective of the study is theme upgrade. | 2016 | 27475682 |
| methylglyoxal and methylglyoxal-modified collagen as inducers of cellular injury in gingival connective tissue cells. | methylglyoxal is a toxic product derived from glucose metabolism that plays a role in inflammation, diabetes and aging. in addition, the periodontal pathogen tannerella forsythensis may also generate this compound. however, the effects of methylglyoxal on gingival cells are still poorly understood. in the present study, we have explored whether methylglyoxal or methylglyoxal-treated collagen may modulate cell viability, death and proliferation in gingival connective tissue cells. in addition, we ... | 2016 | 26847600 |
| human dental stem cells suppress pmn activity after infection with the periodontopathogens prevotella intermedia and tannerella forsythia. | periodontitis is characterized by inflammation associated with the colonization of different oral pathogens. we here aimed to investigate how bacteria and host cells shape their environment in order to limit inflammation and tissue damage in the presence of the pathogen. human dental follicle stem cells (hdfscs) were co-cultured with gram-negative p. intermedia and t. forsythia and were quantified for adherence and internalization as well as migration and interleukin secretion. to delineate hdfs ... | 2016 | 27974831 |
| matrix metalloproteinases outside vertebrates. | the matrix metalloproteinase (mmp) family belongs to the metzincin clan of zinc-dependent metallopeptidases. due to their enormous implications in physiology and disease, mmps have mainly been studied in vertebrates. they are engaged in extracellular protein processing and degradation, and present extensive paralogy, with 23 forms in humans. one characteristic of mmps is a~165-residue catalytic domain (cd), which has been structurally studied for 14 mmps from human, mouse, rat, pig and the oral- ... | 2017 | 28392403 |
| draft genome sequence of tannerella forsythia clinical isolate 9610. | we present here the draft genome sequence of tannerella forsythia 9610, a clinical isolate obtained from a periodontitis patient. the genome is composed of 79 scaffolds with 82 contigs, for a length of 3,201,941 bp and a g+c of 47.3%. | 2017 | 28336586 |
| a pseudaminic acid or a legionaminic acid derivative transferase is strain-specifically implicated in the general protein o-glycosylation system of the periodontal pathogen tannerella forsythia. | the occurrence of nonulosonic acids in bacteria is wide-spread and linked to pathogenicity. however, the knowledge of cognate nonulosonic acid transferases is scarce. in the periodontopathogen tannerella forsythia, several proposed virulence factors carry strain-specifically either a pseudaminic or a legionaminic acid derivative as terminal sugar on an otherwise structurally identical, protein-bound oligosaccharide. this study aims to shed light on the transfer of either nonulosonic acid derivat ... | 2017 | 28334934 |
| macrophage inducible c-type lectin (mincle) recognizes glycosylated surface (s)-layer of the periodontal pathogen tannerella forsythia. | the oral pathogen tannerella forsythia is implicated in the development of periodontitis, a common inflammatory disease that leads to the destruction of the gum and tooth supporting tissues, often leading to tooth loss. t. forsythia is a unique gram-negative organism endowed with an elaborate protein o-glycosylation system that allows the bacterium to express a glycosylated surface (s)-layer comprising two high molecular weight glycoproteins modified with o-linked oligosaccharides. the t. forsyt ... | 2017 | 28264048 |
| tannerella forsythia strains display different cell-surface nonulosonic acids: biosynthetic pathway characterization and first insight into biological implications. | tannerella forsythia is an anaerobic, gram-negative periodontal pathogen. a unique o-linked oligosaccharide decorates the bacterium's cell surface proteins and was shown to modulate the host immune response. in our study, we investigated the biosynthesis of the nonulosonic acid (nulo) present at the terminal position of this glycan. a bioinformatic analysis of t. forsythia genomes revealed a gene locus for the synthesis of pseudaminic acid (pse) in the type strain atcc 43037 while strains fdc 92 ... | 2017 | 27986835 |
| common polymorphisms in the ifi16 and aim2 genes are associated with periodontal disease. | we investigated the single nucleotide polymorphism (snp) context of a previously identified periodontitis-associated locus and examined its association with microbial, biological and periodontal disease clinical parameters. | 2017 | 28387608 |
| behavior of two tannerella forsythia strains and cell surface mutants in multispecies oral biofilms. | as a member of subgingival multispecies biofilms, tannerella forsythia is commonly associated with periodontitis. the bacterium has a characteristic cell surface (s-) layer modified with a unique o-glycan. both the s-layer and the o-glycan were analyzed in this study for their role in biofilm formation by employing an in vitro multispecies biofilm model mimicking the situation in the oral cavity. different t. forsythia strains and mutants with characterized defects in cell surface composition we ... | 2017 | 28382776 |
| dental plaque microbial profiles of children from khartoum, sudan, with congenital heart defects. | few studies have focused on the bacterial species associated with the deterioration of the dental and gingival health of children with congenital heart defects (chd). the aims of this study were (1) to examine the dental plaque of children with chd in order to quantify bacterial load and altered bacterial composition compared with children without chd; and (2) to investigate the correlation between the level of caries and gingivitis and dental biofilm bacteria among those children. in this cross ... | 2017 | 28326155 |
| influence of glycemic control on the levels of subgingival periodontal pathogens in patients with generalized chronic periodontitis and type 2 diabetes. | this study evaluated the influence of glycemic control on the levels and frequency of subgingival periodontal pathogens in patients with type 2 diabetes mellitus (dm) and generalized chronic periodontitis (chp). | 2017 | 28198980 |
| quantitative analysis of periodontal pathogens in periodontitis and gingivitis. | periodontal tissues surround the teeth and provide their attachment. periodontal diseases include a mild and reversible form named gingivitis and periodontitis that is the main cause of tooth loss in adults. gingivitis, that affects gums and coronal junctional epithelium, as well as periodontitis, that is characterized by loss of connective tissue attachment, are caused by a persistent inflammatory response promoted by alteration of periodontal biofilm. the aim of the study was to test whether t ... | 2017 | 26511188 |
| periodontal bacteria in the genital tract: are they related to adverse pregnancy outcome? | one of the most important factors implicated in preterm birth (ptb) is acute genitourinary tract infection. the bacteria causing chronic periodontal inflammation include gram-negative rods and anaerobes similar to those found in women with bacterial vaginosis. the aim of this prospective study is to investigate the relationship between oral and vaginal microflora and preterm low birth weight. real-time polymerase chain reaction was used to detect both the presence and level of six periodontitis- ... | 2017 | 24355228 |
| [the relationship of molecular genetic markers with clinical signs and risk factors of periodontitis]. | the study revealed positive correlation between bleeding on probing and teeth loss risk with periodontal hypercolonization by porphyromonas gingivalis, prevotella intermedia and treponema denticola. pathological tooth mobility was associated with hypercolonization by p. intermedia and tannerella forsythensis. expression of il8, tnf-α, mmp8 and mmp9 genes was also assessed in patient groups divided according to the depth of periodontal pockets and-the severity of chronic periodontitis revealing i ... | 2017 | 27876716 |
| adhesion of porphyromonas gingivalis and tannerella forsythia to dentin and titanium with sandblasted and acid etched surface coated with serum and serum proteins - an in vitro study. | to evaluate the adhesion of selected bacterial strains incl. expression of important virulence factors at dentin and titanium sla surfaces coated with layers of serum proteins. | 2017 | 27825675 |
| the risk reduction of recurrent periodontal pathogens of local application minocycline hcl 2% gel, used as an adjunct to scaling and root planing for chronic periodontitis treatment. | the aim of this study was to evaluate the clinical and microbiological effects of local application minocycline hcl 2% gel, used as an adjunct to scaling and root planing (srp) for treatment of chronic periodontitis (cp). cp is an inflammation of periodontal tissue that is caused mainly by bacterial infection, where periodontal destruction such as loss of attachment and bone destruction occurred. | 2017 | 28331333 |
| clinical and microbiological efficacy of 4% garcinia mangostana l. pericarp gel as local drug delivery in the treatment of chronic periodontitis: a randomized, controlled clinical trial. | the aim of the present study was to assess the periodontal status of individuals and the presence of red complex microorganisms (rcm), such as treponema denticola (td), porphyromonas gingivalis, and tannerella forsythia in the subgingival tissues of periodontitis patients before and after the application of 4% mangostana gel (garcinia mangostana [mga]) as an adjunct to scaling and root planing (srp). | 2017 | 28321995 |
| "association of periodontopathic anaerobic bacterial co-occurrence to atherosclerosis" - a cross-sectional study. | epidemiological studies have shown a link between periodontitis and atherosclerosis. hence the present study was chosen to assess the presence of eight anaerobic periodontal pathogens and their virulence genes in subgingival plaque (sgp) and atheromatous plaque (ap) of patients who underwent coronary artery bypass graft surgery (cabg). | 2017 | 28189829 |
| characterization of the porphyromonas gingivalis type ix secretion trans-envelope porklmnp core complex. | the transport of proteins at the cell surface of bacteroidetes depends on a secretory apparatus known as type ix secretion system (t9ss). this machine is responsible for the cell surface exposition of various proteins, such as adhesins, required for gliding motility in flavobacterium, s-layer components in tannerella forsythia, and tooth tissue-degrading enzymes in the oral pathogen porphyromonas gingivalis although a number of subunits of the t9ss have been identified, we lack details on the ar ... | 2017 | 28057754 |
| low antibiotic resistance among anaerobic gram-negative bacteria in periodontitis 5 years following metronidazole therapy. | the objective of this study was to assess antibiotic susceptibility among predominant gram-negative anaerobic bacteria isolated from periodontitis patients who 5 years prior had been subject to mechanical therapy with or without adjunctive metronidazole. one pooled sample was taken from the 5 deepest sites of each of 161 patients that completed the 5 year follow-up after therapy. the samples were analyzed by culture. a total number of 85 anaerobic strains were isolated from the predominant subgi ... | 2017 | 27988390 |
| molecular-level evaluation of selected periodontal pathogens from subgingival regions in canines and humans with periodontal disease. | dogs commonly serve as a model for various human conditions, including periodontal diseases. the aim of this study was to identify the anaerobic bacteria that colonize the subgingival areas in dogs and humans by using rapid real-time polymerase chain reaction (rt-pcr)-based tests and to compare the results obtained in each species. bacterial microflora evaluations, both quantitative and qualitative, were performed by applying ready-made tests on twelve dogs and twelve humans. five samples were c ... | 2017 | 27297417 |