Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| plasma and pineal melatonin levels in female ferrets housed under long or short photoperiods. | ovohysterectomized female ferrets were housed in controlled environment rooms in which the daily lighting schedule was either 15l:9d (long days) or 9l:15d (short days). after 2 weeks some ferrets in each group were given an intrajugular catheter: beginning 1 week later, a blood sample was taken daily at one of eight different clock times over an 8 to 10 day period. one additional blood sample plus the pineal gland were collected from these animals and from uncathetarized animals in each group af ... | 1986 | 3955143 |
| effect of prenatal exposure to aromatase inhibitor, testosterone, or antiandrogen on the development of feminine sexual behavior in ferrets of both sexes. | experiments were conducted to assess the role of prenatal exposure of the brain to estrogen in controlling the development of proceptive and receptive feminine sexual behavior in ferrets of both sexes. female ferrets, deprived prenatally of estrogen via maternal ovariectomy on gestational day 30 (42-day gestation) plus sc implantation of an aromatase inhibitor, 1,4,6-androstatriene-3,17-dione (atd), into their mothers, were significantly less receptive than control females when tested in adultho ... | 1986 | 3737708 |
| effects of platelet activating factor on tracheal mucus secretion, on airway mechanics and on circulating blood cells in live ferrets. | 1986 | 3465554 | |
| imprinting on prey odours in ferrets (mustela putorius f. furo l. ) and its neural correlates. | the effect of different feeding conditions during ontogeny was investigated in the carnivorous ferret. behavioral tests and cardiac responses towards known and unknown odours as well as food choice tests showed that in this species olfaction plays an important role for prey recognition. yet, the knowledge of the prey odours has to be learned during a sensitive phase which was found to exist between postnatal days 60 and 90. in adult ferrets, searching for prey can be elicited reliably by familia ... | 1986 | 24924694 |
| effects of partial truncal vagotomy on intragastric pressure responses to vagal stimulation and gastric distension in ferrets. | changes in intragastric pressure after dorsal truncal vagotomy, investigated by stimulation of the surviving vagal branches and by step inflation of the stomach, were divided into an early phase lasting five days, and a late phase continuing for at least three months. during the early phase the amplitude of vagal evoked contraction was diminished but the resting pressure and the response to gastric inflation were increased. after the fifth day vagal evoked contractions doubled in amplitude but t ... | 1987 | 3428683 |
| early uncrossed component of the developing optic nerve with a short extracerebral course: a light and electron microscopic study of fetal ferrets. | during the study of the developing optic nerve described in the preceding paper (guillery and walsh, '87), small bundles of nerve fibers were seen passing between the optic nerve and the ipsilateral hypothalamus of 24-to 27-day-old prenatal ferrets. the bundles appear before any other fiber groups of the retinofugal pathway and are identifiable while the main portions of the retinofugal system are growing into the optic tracts. the bundles, made up of 50 or more axons, leave the optic nerve, eme ... | 1987 | 3693607 |
| changing glial organization relates to changing fiber order in the developing optic nerve of ferrets. | the structures of the developing eye-stalk and the relationships of early retinofugal fibers as they pass through the stalk, chiasm, and tract have been studied by light and electron microscopical methods in fetal ferrets aged 23-27 days. the early eye-stalk can be divided into two parts: a narrow extracranial part has a narrow lumen and is lined by few cells, whereas a thicker intracranial part has a wider lumen and is lined by several rows of cells. at the earliest stages no axon bundles are r ... | 1987 | 3693606 |
| inhalation toxicity of ribavirin in suckling ferrets. | ribavirin is a broad-spectrum antiviral agent useful for treatment of infants. to study the effects in developing mammalian lungs, four groups of jill ferrets and their litters were given whole body inhalation exposures for 6 h a day for 10 or 30 consecutive days to concentrations of 0 (vehicle control), 162, 355 or 620 mg/m3. the effects, including special lung observations in suckling kits, were evaluated after exposures at weaning and at puberty. first the high dose, then the mid dose jills d ... | 1987 | 3680851 |
| evidence that a decrease in testosterone negative feedback mediates the pubertal increase in luteinizing hormone pulse frequency in male ferrets. | neuroendocrine mechanisms regulating luteinizing hormone (lh) secretion during puberty were investigated in intact male ferrets and ferrets castrated at 8 wk of age that received s.c. implants of either empty or testosterone-filled silastic capsules. to synchronize puberty onset among individuals, ferrets were exposed to short days between 8 and 16 wk of age, and then transferred to long days. testis growth began in intact ferrets soon after photoperiod transition. blood samples were obtained at ... | 1987 | 3651552 |
| evidence that 5-hydroxytryptamine3 receptors mediate cytotoxic drug and radiation-evoked emesis. | the involvement of 5-hydroxytryptamine (5-ht) 5-ht3 receptors in the mechanisms of severe emesis evoked by cytotoxic drugs or by total body irradiation have been studied in ferrets. anti-emetic compounds tested were domperidone (a dopamine antagonist), metoclopramide (a gastric motility stimulant and dopamine antagonist at conventional doses, a 5-ht3 receptor antagonist at higher doses) and brl 24924 (a potent gastric motility stimulant and a 5-ht3 receptor antagonist). domperidone or metoclopra ... | 1987 | 3311109 |
| habitat structure and predators: choices and consequences for rodent habitat specialists and generalists. | both habitat structure and risk of predation are thought to influence rodent community composition in different habitats, but experiments on the degree to which these factors determine the use of habitat by rodents are lacking. i sought to discover (1) if cover density altered habitat choice and (2) if cover density affected the vulnerability to predators of two rodents, a habitat specialist and a habitat generalist. in laboratory experiments, the habitat specialist, the red-backed vole (clethri ... | 1987 | 28312894 |
| toxicity of thiram (tetramethylthiuram disulfide) to mink and european ferrets. | 1987 | 3567399 | |
| [halothane intubation anesthesia during controlled respiration in ferrets]. | 1987 | 3673292 | |
| effects of the paf-antagonist cv-3988 on paf-induced changes in mucus secretion and in respiratory and circulatory variables in ferrets. | 1987 | 3479001 | |
| [aplastic anemia in ferrets]. | the present report describes both estrus associated and estrogen induced aplastic anemia in 7 female ferrets. the animals were presented with anemia, anorexia, apathy, melena and subcutaneous hemorrhages. histologically, the animals showed panmyelophthisis and cystic endometrial hyperplasia. | 1987 | 3424362 |
| effects of cyproterone acetate on mating behavior, testicular morphology, testosterone level, and body temperature in male ferrets in comparison with normal and castrated males. | effects of surgical castration of 60-day-old male ferrets are compared with the effects of a chemical castration with cyproterone acetate from postnatal day 60 until 360. investigations were made on mating behavior, intermale aggression, testicular morphology, plasma testosterone level and body temperature. while controls show seasonal variations in all parameters, according to the annual cycle of sexual activity and inactivity, both, surgically and chemically castrated ferrets show throughout t ... | 1987 | 2952572 |
| host cell-mediated variation in h3n2 influenza viruses. | the influence of the host cell on the selection of antigenic variants of influenza a h3n2 viruses and the relevance of host cell selection to the induction of immunity by these viruses have been investigated. influenza viruses were isolated from human clinical samples during a single epidemic, were passaged in mammalian madin-darby canine kidney (mdck) cells or in embryonated hens eggs, and were tested for antigenic variability in the hemagglutinin (ha) molecule with a panel of monoclonal antibo ... | 1987 | 3811239 |
| mucus secretion by tracheas of ferret and dog. | mucus secretion, stimulated by nerve excitation or drugs, was measured from the ferret trachea in vitro by two methods: from the whole trachea, and compared with the volume of submucosal glands estimated from histological sections; and from mounted segments of trachea, by displacement of tantalum dust applied to the epithelium and compared with changes in tissue volume estimated by probing the epithelial surface between hillocks. maximal secretion rates (2-3 microliters x min-1 x cm-2) with trac ... | 1987 | 3817064 |
| production of passive immunity in neonatal ferrets following maternal vaccination with killed influenza a virus vaccines. | neonatal ferrets may be passively immunized following maternal vaccination with formalin-inactivated influenza a virus vaccine, but the level of protection from partial to complete depends upon the number of doses used to vaccinate the mother, the presence or absence of aluminum hydroxide adjuvant, whether or not the mothers were 'primed' by prior infection with a serologically heterologous type a virus, and the age of the neonate at challenge. neonates were completely protected up to 2 weeks of ... | 1987 | 3817868 |
| pathophysiology and pathogenesis of stunned myocardium. depressed ca2+ activation of contraction as a consequence of reperfusion-induced cellular calcium overload in ferret hearts. | contractile dysfunction in stunned myocardium could result from a decrease in the intracellular free [ca2+] transient during each beat, a decrease in maximal ca2+-activated force, or a shift in myofilament ca2+ sensitivity. we measured developed pressure (dp) at several [ca]0 (0.5-7.5 mm) in isovolumic langendorff-perfused ferret hearts at 37 degrees c after 15 min of global ischemia (stunned group, n = 13) or in a nonischemic control group (n = 6). at all [ca]0, dp was depressed in the stunned ... | 1987 | 3818956 |
| vagal afferent discharge from gastric mechanoreceptors during contraction and relaxation of the ferret corpus. | vagal afferent fibres with mechanoreceptive fields in the gastric corpus were studied electrophysiologically in the urethane-anaesthetized ferret in an attempt to assess how changes in muscle tension and length modulate receptor discharge. single afferent units were spontaneously active and increased their firing on distension of the corpus. during vagally evoked isovolumetric contractions and relaxations, the afferent discharge closely followed changes in intracorpus pressure. under near-isoton ... | 1987 | 3819312 |
| response of epithelial cells of the choroid plexus in the ferret model for reye's syndrome. | the structural integrity of epithelial cells of the lateral choroid plexus tissues from the ferret model for reye's syndrome was examined by transmission electron microscopy after the animals were inoculated intranasally with influenza b, were administered aspirin, and/or were fed an arginine deficient diet singly and in combination. no cellular alteration in the choroidal epithelium was caused by influenza b nor by aspirin, however, the synthetic diet produced random intercellular edema. the st ... | 1987 | 3821066 |
| does the substantia nigra have a cholinergic innervation? | we have studied the distribution of choline acetyltransferase-containing fibres in ferret substantia nigra using immunohistochemistry at the light microscopical level. positive staining for choline acetyltransferase was not observed in any nigral cell bodies, but was found in a network of fine-calibre, varicose axons, more densely distributed in the zona compacta than the zona reticulata. | 1987 | 3822242 |
| correlation of force-length area with oxygen consumption in ferret papillary muscle. | the ventricular systolic pressure-volume area correlates well with myocardial oxygen consumption. however, in isolated muscle preparations, there are experimental data based on both mechanical and energetic measurements that suggest that the pressure-volume area concept may not obtain. in the present study, force-length area, the analog of pressure-volume area for a linear muscle, was examined in the ferret papillary muscle preparation under a wide range of loading conditions. there were two maj ... | 1987 | 3621495 |
| locus of hypoxic vasoconstriction in isolated ferret lungs. | to determine whether hypoxic pulmonary vasoconstriction (hpv) occurs mainly in alveolar or extra-alveolar vessels in ferrets, we used two groups of isolated lungs perfused with autologous blood and a constant left atrial pressure (-5 torr). in the first group, flow (q) was held constant at 50, 100, and 150 ml.kg-1 x min-1, and changes in pulmonary arterial pressure (ppa) were recorded as alveolar pressure (palv) was lowered from 25 to 0 torr during control [inspired partial pressure of o2 (pio2) ... | 1987 | 3624150 |
| intracellular neutral carrier-based ca2+ microelectrode with subnanomolar detection limit. | in intracellular electrolyte solutions a ca2+-selective microelectrode based on the synthetic electrically neutral carrier n,n,n',n'-tetracyclohexyl-3-oxapentanediamide (eth 129) shows an improved detection limit when compared with the so far widely used ca2+ microelectrodes based on the neutral carrier eth 1001. detection limits are found at pca = 9.2 in ca2+ buffers containing an intracellular background of k+ (125 mm). selectivity studies in mixed solutions show a preference of ca2+ over na+ ... | 1987 | 3627942 |
| differential effects of reoxygenation on intracellular calcium and isometric tension. | we used the bioluminescent ca2+ indicator, aequorin to record intracellular calcium transients during reoxygenation of hypoxic ferret ventricular muscle in order to determine whether alterations in the amplitude and time course of isometric contraction are mediated by changes in [ca2+]i. papillary muscles less than or equal to 1 mm in diameter were removed from the hearts of male ferrets and perfused with a bicarbonate-buffered physiologic salt solution at 30 degrees c. muscles were stimulated t ... | 1987 | 3627961 |
| the inhibitory enteric nerves of the gastric corpus and the ileum of the ferret. | 1987 | 3628313 | |
| oestrogen toxicity in the ferret. | 1987 | 3651327 | |
| platelet activating factor stimulates secretion of mucin by explants of rodent airways in organ culture. | platelet activating factor (paf; 1-o-alkyl-2-0-acetyl-sn-glycero-3-phosphocholine-3-phosphocholine) a potential mediator of anaphylaxis, stimulates secretion of mucin by explants of trachea from four separate rodent species (guinea pig, rat, rabbit, ferret) in organ culture. enhanced secretion is not a result of cell damage or release of histamine by cells within the explants (e.g., platelets). it is inhibited by equimolar concentrations of the potent paf-receptor antagonist, ro 19-3704. paf pro ... | 1987 | 3653044 |
| autoradiographic studies of the distribution of 35sulfate label in ferret trachea: effects of stimulation. | na2(35)so4 is among the common isotopic mucin precursors used to label airway secretory cells and monitor their active discharge in response to drugs. previous work has established that 35s is taken up by multiple cell types in the trachea, yet there is no direct evidence linking 35s release with secretory activity by any specific cell type. in this study, we have used autoradiography to identify the sites of uptake and release of 35s in ferret trachea. confirming work performed in other species ... | 1987 | 3653046 |
| hyperadrenocorticism in a ferret. | a 7-year-old adult male ferret had progressive hair loss that was bilaterally symmetric. also clinically evident were severe dehydration, polydipsia, muffled heart sounds, weak femoral pulses, hepatomegaly, lethargy, weakness, temporal muscular atrophy, dyspnea, and weakness. the blood profile of the ferret indicated profound leukopenia, eosinopenia, and high phosphorus, bun, creatinine, and potassium concentrations, as well as high aspartate transaminase activity; the albumin concentration was ... | 1987 | 3654302 |
| ultrastructure of the ferret parotid gland. | parotid glands of two male and two female adult ferrets were examined using electron microscopy. the acinar cells contained an abundance of rough endoplasmic reticulum, an extensive golgi complex, and electron-dense granules with a denser spot in each. the acinar lumen and the intercellular canaliculi were lined by a large number of prominent microvilli. the intercalated ducts were long and in their proximal part the cells contained small electron-dense granules, whereas the distal portions were ... | 1987 | 3654374 |
| intracellular ph in sheep purkinje fibres and ferret papillary muscles during hypoxia and recovery. | 1. the changes of intracellular ph (phi) of papillary muscles from ferret and purkinje fibres from sheep heart during hypoxia and recovery from hypoxia were recorded with ph-sensitive micro-electrodes filled with neutral h+ carrier. 2. hypoxia was produced by replacement of o2 with n2 in the superfusing solutions. when oxidative phosphorylation was prevented, developed tension fell within 20 min to about 16 and 21% of its control value for papillary muscle and purkinje fibres respectively. on re ... | 1987 | 3656122 |
| the role of the sarcoplasmic reticulum in the response of ferret and rat heart muscle to acidosis. | 1. the photoprotein aequorin was micro-injected into papillary muscles from the right ventricle of ferrets and rats. tension and aequorin light (a function of intracellular [ca2+]) were monitored. 2. in stimulated ferret papillary muscles, increasing the [co2] of the bicarbonate-buffered superfusate from 5% (ph 7.35) to 20% (ph 6.8) led to a rapid decrease of developed tension, with no significant change in the size of the intracellular ca2+ transient which accompanies contraction. there was the ... | 1987 | 3656151 |
| modulation of the vagal drive to the intramural cholinergic and non-cholinergic neurones in the ferret stomach by baclofen. | 1. in the urethane-anaesthetized ferret vagotomy (cervical and abdominal) and hexamethonium both produced an increase in gastric corpus pressure after treatment with atropine and guanethidine, section of the greater splanchnic nerves and adrenalectomy. 2. the pressure increase was due to an interruption of a tonic vagal drive to the intramural non-adrenergic, non-cholinergic inhibitory neurones. 3. the gabab receptor agonist baclofen (8 mg/kg s.c.) produced an increase in gastric pressure and en ... | 1987 | 3656193 |
| features of developing ferret tracheal epithelium: ultrastructural observations of in vivo and in vitro differentiation of ciliated cells. | ultrastructural features of the developing, surface epithelium of ferrets from birth to 28 days of age were characterized. progressive ciliogenesis in vivo was observed, beginning with cells covering the membranous portion of the trachea. emerging cilia appeared in ultrathin sections and by scanning electron microscopy at sites correlating with accumulation of integral membrane particles seen in freeze-fracture preparations. two patterns of ciliogenesis were observed: (1) the random emergence of ... | 1987 | 3665853 |
| in vitro binding and utilization of lipoproteins by luteal cells from ferrets treated with dopaminergic drugs during pseudopregnancy. | the effects of administration of dopaminergic drugs in vivo on the binding and utilization of lipoproteins for progesterone synthesis in vitro by ferret luteal cells were investigated. pimozide, a dopamine antagonist, and bromoergocriptine (cb-154), a dopamine agonist, were administered to pseudopregnant ferrets to alter prolactin (prl) concentrations daily beginning the day after ovulation. the control group received the vehicle solution only. corpora lutea taken on day 13 after ovulation were ... | 1987 | 3666406 |
| role of milk-derived igg in passive maternal protection of neonatal ferrets against influenza. | neonatal ferrets are protected against infection with influenza virus by colostral and milk-derived anti-influenza virus igg after suckling on an immune mother. the levels of igg elicited and then transmitted to neonates were similar when mothers were immunized by either live infection or killed vaccines. maternal anti-influenza virus iga and igm appears not to cross the neonatal gut epithelium although both are present in maternal serum and milk. | 1987 | 3668509 |
| evidence for an extra-abdominal site of action for the 5-ht3 receptor antagonist brl24924 in the inhibition of radiation-evoked emesis in the ferret. | recent studies have implicated 5-ht3(5-ht-m) receptors in the genesis of retching and vomiting evoked by antineoplastic agents. such receptors have so far only been located peripherally, notably on the vagus. therefore, the effects of bilateral abdominal vagotomy and antagonism of 5-ht3 receptors have been investigated on retching and vomiting induced by radiation. the gastrokinetic substituted benzamide brl24924, (beecham pharmaceuticals) which has 5-ht3 receptor antagonist properties, was used ... | 1987 | 3670559 |
| reproductive state and motor activity in female ferrets. | the pattern of motor activity in female ferrets (mustela putorius furo) housed in cages mounted upon rocker platforms was followed under conditions of short-(8 hr) and long-(16 hr) day illumination. a distinct diurnal rhythm was evident that remained unchanged after lesioning of the anterior hypothalamus. the level of activity did not differ between animals kept under short days and long days, between anoestrous and oestrous females, or during the development or waning of oestrus. ovariectomy di ... | 1987 | 3671541 |
| the ferret as a model for endogenous synthesis and metabolism of n-nitrosamines. | we have begun to evaluate the ferret as a model for studying gastric nitrosation and nitrosamine metabolism. jugular cannulation allows convenient dosing and sampling of blood, and this technique has been used to study clearance of n-nitrosodimethylamine (ndma) after intravenous, intraperitoneal and intragastric administration. ndma metabolism can be inhibited by 4-methylpyrazole for up to 24 h; the accumulation of endogenously-synthesized ndma can therefore be observed in animals following pret ... | 1987 | 3679351 |
| comparative sensitivities to antimicrobial agents of campylobacter pylori and the gastric campylobacter like organism from the ferret. | 1987 | 3680554 | |
| cystic mucinous hyperplasia in the gallbladder of a ferret. | an 8-year-old male ferret had icterus, hepatomegaly and an enlarged gallbladder. microscopically, the gallbladder had numerous mucinous cysts and papillary hyperplasia of the mucosa, consistent with a diagnosis of cystic mucinous hyperplasia. no previous published reports of this condition in ferrets were found. | 1987 | 3680648 |
| the actions of methacholine, phenylephrine, salbutamol and histamine on mucus secretion from the ferret in-vitro trachea. | methacholine, phenylephrine and histamine produced highly significant and salbutamol significant increases in the rate of mucus secretion from the ferret trachea. methacholine, phenylephrine and histamine all produced highly significant increases in the rate of output of lysozyme, but the concentration of lysozyme in the mucus was significantly increased only by phenylephrine. salbutamol produced no significant change in the output of lysozyme, and the concentration of lysozyme in the mucus was ... | 1987 | 3687600 |
| the effects of peptides and mediators on mucus secretion rate and smooth muscle tone in the ferret trachea. | the effects of a number of peptides and mediators were measured on the secretion rate of tracheal mucus and tracheal smooth muscle tone in the ferret in vitro whole trachea. the comparison of secretion rate and smooth muscle tone, measured simultaneously in the same preparation, shows that there are wide differences in sensitivity between the two systems; there appears to be no relationship between mucus volume output and smooth muscle contraction. the comparison of mucus secretion rate and glyc ... | 1987 | 3687601 |
| spatial properties of neurones in the lateral geniculate nucleus of the pigmented ferret. | we used quantitative electrophysiological techniques to study the spatial properties of single units recorded extracellularly in the lateral geniculate and perigeniculate nuclei of the adult pigmented ferret. all neurones examined had approximately circular receptive fields, whose central regions gave responses antagonistic to those elicited from the surrounds. we presented sinusoidally modulated grating patterns, either drifting or counterphased, to obtain spatial frequency tuning curves, contr ... | 1987 | 3691695 |
| enhanced inflammation to brugia malayi microfilariae in ferrets infected with trichinella spiralis. | 1987 | 3437363 | |
| a bony growth of the skull in a ferret. | 1987 | 3437754 | |
| species variation in the coronary collateral circulation during regional myocardial ischaemia: a critical determinant of the rate of evolution and extent of myocardial infarction. | to determine residual flow to ischaemic tissue, which is the primary determinant of the rate of development and ultimate size of the myocardial infarct resulting from coronary artery occlusion, the coronary collateral circulation was quantified during acute myocardial ischaemia in eight species in vivo using the radiolabelled microsphere technique. in each case, a prominent branch of the left coronary artery was ligated, and within 5 min microspheres (141ce labelled, 15 micron diameter) were inj ... | 1987 | 3440266 |
| ultrastructure of the ferret submandibular gland. | submandibular glands of two male and two female adult ferrets were examined using electron microscopy. the secretory endpiece consisted of mucous acini and seromucous demilunes. the acinar cells were filled with mucous granules of moderate electron density. each granule had a fine fibrillar substructure. two types of demilune cells could be identified, based on the differing electron density of their secretion granules. in some cells the granules were more electron-dense than in others. these gr ... | 1987 | 3446664 |
| food intake and struvite crystalluria in ferrets. | four adult, castrated, male ferrets were studied in two similar trials for effects of food intake on variables hypothesized to promote struvite (ammonium, magnesium, phosphate hexahydrate) crystal formation in urine. struvite crystalluria occurred in three of the four ferrets. urine ph (uph) averaged 6.6 for these ferrets. uph in the ferret without crystalluria was 6.0. by simple linear regression analysis, no relationship was found between the amount of food ingested and the urinary concentrati ... | 1987 | 3451569 |
| tissue response to retrograde root fillings in the ferret canine: a comparison of a glass ionomer cement and gutta-percha with sealer. | tissue healing was compared after apicectomy and filling of ferret lower canines with glass ionomer (ketacfil) or gutta-percha/sealer (tubliseal). both materials provoked an inflammatory response after 7 days, but the response to glass ionomer was less severe. the response after 28 days was different. mild inflammation related to the gutta-percha was still present, but no inflammation was found in relation to the glass ionomer. bone infill was quite advanced in all specimens at 28 days but was m ... | 1987 | 3477771 |
| experimental pneumocystis carinii pneumonia in the ferret. | pneumocystis carinii pneumonia (pcp) was provoked in the ferret, mustela pulorius furo, by immunosuppression with daily long-term administration of cortisone acetate, 10-20 mg/kg subcutaneously for 9 to 10 weeks, microscopically p. carinii was observed in the lungs of all 11 treated animals: mild to moderate in five and extensive disease in six. the histopathological features of pcp in the ferret included interstitial pneumonitis, scant mononuclear cell alveolitis, with abundant cysts and tropho ... | 1987 | 3495285 |
| serological studies with influenza a(h1n1) viruses cultivated in eggs or in a canine kidney cell line (mdck). | pairs of influenza a(h1n1) viruses cultivated from the same clinical specimen in canine kidney (mdck) cells or in embryonated hens' eggs can frequently be distinguished by their reactions with monoclonal antibodies to haemagglutinin and with antibodies in ferret or human sera. egg-adapted virus, further passaged in mdck cultures remained "egg-like" in serological characteristics indicating that the differences in their serological reactions were not a direct result of host cell-dependent glycosy ... | 1987 | 3496984 |
| differential production of endogenous pyrogen by human peripheral blood leucocytes following interaction with h3n2 or h1n1 influenza viruses of differing virulence. | fever and other constitutional effects of influenza (headache, myalgia, listlessness, nausea, shivering, anorexia and depression) result from liberation of endogenous pyrogen (ep) from phagocytes. these effects are milder for recent h1n1 influenza virus isolates than for h3n2 strains. interaction with human peripheral blood leucocytes in vitro showed that h1n1 strains, a/ussr/90/77 and a/fiji/15899/83, elicited significantly less ep (as assessed by the rabbit pyrogen assay) than two virulent clo ... | 1987 | 3504218 |
| genetics of cold-adapted b/ann arbor/1/66 influenza virus reassortants: the acidic polymerase (pa) protein gene confers temperature sensitivity and attenuated virulence. | the cold-adapted b/ann arbor/1/66 influenza virus (ca b/aa/1/66) expresses temperature-sensitive (ts), cold-adapted (ca) and attenuation phenotypes. reassortants which inherit one or more genes from ca b/aa/1/66 and all other genes from a virulent, wild-type influenza virus, b/houston/1732/76, were produced and evaluated in order to identify the gene(s) responsible for the ts, ca and attenuation phenotypes. only reassortants which inherited the pa gene from ca b/aa/1/66 expressed the ts phenotyp ... | 1987 | 3504545 |
| maximal ca2+-activated force and myofilament ca2+ sensitivity in intact mammalian hearts. differential effects of inorganic phosphate and hydrogen ions. | myofilament ca2+ sensitivity and maximal ca2+-activated force are fundamental properties of the contractile proteins in the heart. although these properties can be evaluated directly in skinned preparations, they have remained elusive in intact tissue. a novel approach is described that allows maximal ca2+-activated force to be measured and myofilament ca2+ sensitivity to be deduced from isovolumic pressure in intact perfused ferret hearts. phosphorus nuclear magnetic resonance spectra are obtai ... | 1987 | 3694173 |
| uterine luminal proteins during the preimplantation period in the ferret. | the pattern of synthesis of uterine luminal proteins during the 6-day preimplantation period of the ferret has been analyzed by polyacrylamide gel electrophoresis and fluorography. the results demonstrate that several classes of protein, in particular those of molecular weights of 75,000, 58,000, 50,000, 18,000, and 8,000, are actively synthesized and appear in the uterine lumen during this period. quantitative changes in the amount of radioactivity incorporated by specific proteins as viewed on ... | 1987 | 3612055 |
| use of steroids and a long-acting vasoconstrictor in the treatment of postintubation croup. a ferret model. | there is little in the literature to support recommendations for the use of steroids and vasoconstrictors in the treatment of postintubation croup. we developed a ferret model to study this condition. ninety-eight ferrets were used in these experiments, which were undertaken to evaluate the efficacy of steroids and/or a long-acting vasoconstrictor, to develop dose-response curves for dexamethasone sodium phosphate if it proved efficacious, and to evaluate the possible synergistic effects of comb ... | 1987 | 3620146 |
| campylobacter jejuni infection in the ferret: an animal model of human campylobacteriosis. | campylobacter infection in weanling ferrets (mustela putorius furo) was studied as an animal model for enteric campylobacteriosis in persons. the screening of fecal cultures on selective campylobacter media showed that campylobacter jejuni/coli was not present in the normal enteric flora. intragastric feeding of a mixture of cat feed and 2.5 x 10(8) c jejuni isolated from ferrets with naturally occurring proliferative colitis was accomplished. all ferrets (n = 8) became infected on 3 days after ... | 1987 | 3826848 |
| canine distemper virus: in vivo virulence of in vitro-passaged persistent virus strains. | groups of ferrets were inoculated intraperitoneally with cell lysates or equivalent doses of whole cells from 9 different cell lines persistently infected with canine distemper virus. viral persistence in these cell lines was characterized by noncytolytic infection and restricted release of cell-free infectious virus. in vivo replication competency of the various viruses in ferrets ranged from nil to virulent and did not correlate with in vitro titers of inocula. ferret virulence (cell lysates o ... | 1987 | 3826861 |
| intestinal replication of influenza a viruses in two mammalian species. brief report. | the sites of replication of influenza a viruses in ferrets and pigs were studied. the majority of the swine, equine, and avian influenza a viruses tested were recovered from the intestinal tract of ferrets as well as from the respiratory tract; most of the human influenza viruses studied were recovered only from the respiratory tract. in contrast with ferrets, only hong kong/1/68 (h 3 n 2) influenza virus was recovered from the intestinal tract of pigs. despite the large biological variability f ... | 1987 | 3827601 |
| the effects of cyanide on intracellular ionic exchange in ferret and rat ventricular myocardium. | the effects of cyanide on ca2+ exchange in isolated ventricular myocytes and on the intracellular concentrations of ca2+, na+ and h+ have been investigated to assess the contribution that mitochondria might play in cellular ca2+ metabolism. ionic levels were measured with ion-selective electrodes. kcn (2.5 mm) inhibited a component of ca2+ exchange in myocytes that could be attributed to mitochondrial exchange, but was without effect on non-mitochondrial ca2+ exchange. nacn (2.5 mm) caused a tra ... | 1987 | 2884664 |
| a small proportion of cholinergic neurones in the nucleus basalis magnocellularis of ferret appear to stain positively for tyrosine hydroxylase. | the immunofluorescence and peroxidase-antiperoxidase methods for immunohistochemistry were used to show that a small number of neurones in the nucleus basalis magnocellularis of ferret stain positively for what appears to be tyrosine hydroxylase, a marker for catecholaminergic neurones. with a double immunocytochemical staining method, it was confirmed that the tyrosine hydroxylase-like immunoreactivity is localized in neurones that also stain strongly for choline acetyltransferase. | 1987 | 2886187 |
| comparisons of feline panleukopenia virus, canine parvovirus, raccoon parvovirus, and mink enteritis virus and their pathogenicity for mink and ferrets. | parvoviruses from mink (mink enteritis virus [mev]), cats (feline panleukopenia virus [fpv]), raccoons (raccoon parvovirus [rpv]), and dogs (canine parvovirus [cpv]) were compared. restriction enzyme analysis of the viral replicative-form dna revealed no consistent differences between fpv and rpv isolates, but cpv and mev isolates could be distinguished readily from other virus types. feline panleukopenia virus, rpv, and mev, but not cpv, replicated to high titers in mink. however, on the first ... | 1987 | 2823648 |
| a method for recording isometric tension development by isolated cardiac myocytes: transducer attachment with fibrin glue. | the purpose of this study was to develop a method for attachment of single isolated cardiac myocytes to a transducer for recording isometric tension development. cardiac myocytes were isolated from the hearts of the toad, bufo marinus or ferrets by enzymatic digestion with collagenase. the method that we used provided a 60-80% yield of ca++-tolerant cells. a suspension of cells was placed into a superfusion chamber coated with bovine thrombin. two glass microtools - each attached to a micromanip ... | 1987 | 2437526 |
| characterization of substance p- and [met]enkephalin-immunoreactive neurons in the caudate nucleus of cat and ferret by a single section golgi procedure. | modifications of the single-section golgi-impregnation procedure of gabbott and somogyi are described. the modifications allow easier and more rapid preparation of the sections for golgi-impregnation and easier handling of large numbers of serial sections. the technique consists of placing a section that has been treated with osmium tetroxide and potassium dichromate on a microscope slide and "sandwiching" it with a second microscope slide. the two slides are held together at one end by tape and ... | 1987 | 2438593 |
| intracellular sodium-calcium dissociation in early contractile failure in hypoxic ferret papillary muscles. | 1. intracellular sodium activity (anai) and intracellular calcium activity (acai) were measured in isolated quiescent right-ventricular ferret muscle: anai = 9.8 +/- 2.2 mm and acai = 71 +/- 19 nm. 2. when the muscles were exposed to 10(-5) m-ouabain, anai increased to 20.4 +/- 3.1 mm while acai increased to 260 +/- 99 nm. twitch tension approximately doubled. 3. during prolonged hypoxia with glucose in the perfusate, anai and twitch tension were unchanged. 4. during prolonged hypoxia with sucro ... | 1987 | 2443694 |
| enkephalinase inhibitor potentiates substance p- and electrically induced contraction in ferret trachea. | to determine the role of endogenous enkephalinase (ec 3.4.24.11) in regulating peptide-induced contraction of airway smooth muscle, we studied the effect of the enkephalinase inhibitor, leucine-thiorphan (leu-thiorphan), on responses of isolated ferret tracheal smooth muscle segments to substance p (sp) and to electrical field stimulation (efs). leu-thiorphan shifted the dose-response curve to sp to lower concentrations. atropine or the sp antagonist [d-pro2,d-trp7,9]sp significantly inhibited s ... | 1987 | 2447055 |
| enkephalinase inhibitor potentiates mammalian tachykinin-induced contraction in ferret trachea. | to determine the roles of endogenous enkephalinase (ec.3.4.24.11) in regulating tachykinin-induced contraction of airway smooth muscle, the authors studied the effects of the enkephalinase inhibitor leucine-thiorphan on the contractile responses to substance p (sp), neurokinin a (nka) and neurokinin b (nkb) in isolated ferret tracheal smooth muscle segments. leucine-thiorphan shifted, in concentration-dependent fashions, the dose-response curves to all tachykinins to lower concentrations. leucin ... | 1987 | 2447268 |
| restricted viral antibody specificity in many ferrets infected with the ferret aleutian disease parvovirus. brief report. | the majority of ferrets infected with a ferret strain of aleutian disease virus (adv) produce antibody only to a detergent-sensitive common determinant on the two closely related virion proteins. ferrets with high antibody titers and mink infected with this virus also produce antibody to one or more virion immunogenic determinants unaffected by detergent. | 1987 | 2434063 |
| enkephalinase inhibitors potentiate substance p-induced secretion of 35so4-macromolecules from ferret trachea. | to study the roles of substance p (sp) and endogenous peptidases in regulating mucus secretion from ferret trachea, we measured the sp-induced release of 35so4-labeled macromolecules after incubating segments of trachea in ussing chambers in the presence and absence of selected inhibitors of proteolytic enzymes. our strategy was based on the idea that if endogenous peptidases degrade sp, then inhibitors of these enzymes should potentiate sp-induced secretion. we found that tracheas of ferrets co ... | 1987 | 2434322 |
| intrinsic nerves in the mammalian colon: confirmation of a plexus at the circular muscle-submucosal interface. | slow waves in the small intestine seem to arise in plexuses of neurites with interstitial cells of cajal. in the colon, slow waves appear to arise at the circular muscle - submucosal interface. we therefore sought a plexus at this surface in the colon in the cat, dog, ferret, opossum, rabbit, rat, guinea-pig and man. segments from all levels of the colon were stained by the champy-maillet osmic acid-zinc iodide method and cut into serial 25 micron sections in the plane of the muscle layers. a de ... | 1987 | 2453550 |
| effect of alpha-adrenoceptor stimulation of isolated canine, ferret and guinea pig airways. | functional responses and subtypes of alpha-adrenoceptors in canine trachealis smooth muscle were investigated using the agonists; epinephrine, norepinephrine, sk&f 89748 (alpha 1-selective) and bht-933 (alpha 2-selective) in the presence of a beta-adrenoceptor antagonist. tissue contractility to these agonists was in the range of 16 to 46% of the maximum response to serotonin. sk&f 89748 was most effective in canine airways; however, the contractions could be abolished by methysergide. neither p ... | 1987 | 2888935 |
| direct and relayed projection of periodontal receptor afferents to the cerebellum in the ferret. | field potentials in the cerebellar cortex of the ferret have been studied in response to stimulation of alveolar, muscular and cutaneous branches of the trigeminal nerve. responses from the alveolar nerves are unusual in their very short latency. evidence based on latency analysis, frequency following and comparison with other well-known inputs supports the view that the earliest field potentials are due to direct, unrelayed afferents, which terminate as mossy fibres. there is, in addition, a mo ... | 1987 | 2889211 |
| emesis induced by cisplatin in the ferret as a model for the detection of anti-emetic drugs. | the intravenous injection of cisplatin in the ferret caused a consistent emetic (vomiting/retching) response. emesis induced by cisplatin was abolished by the 5-hydroxytryptamine (5-ht) m-receptor antagonists ics205-930, zacopride, dazopride and metoclopramide. the neuroleptic agents haloperidol, fluphenazine, domperidone, sulpiride and tiapride also antagonized emesis induced by cisplatin but only a proportion of the animals were completely protected and diazepam and prednisolone only reduced t ... | 1987 | 2890117 |
| catecholaminergic properties of cholinergic neurons and synapses in adult rat ciliary ganglion. | parasympathetic neurons of the ciliary ganglion are innervated by preganglionic cholinergic neurons whose cell bodies lie in the brain stem; the ganglion cells in turn provide cholinergic innervation to the intrinsic muscles of the eye. noradrenergic innervation of the iris is supplied by sympathetic neurons of the superior cervical ganglion. using immunocytochemical and histochemical techniques, we have examined the ciliary ganglion of adult rats for the expression of cholinergic and noradrener ... | 1987 | 2890721 |
| catecholaminergic horizontal and amacrine cells in the ferret retina. | enzymes involved in the synthesis of catecholamines were detected in amacrine and what appeared to be a specific class of horizontal cells in the ferret retina. antisera directed against the enzymes tyrosine hydroxylase (th), which converts tyrosine to dopa, and phenylethanolamine n-methyl-transferase (pnmt), which converts norepinephrine to epinephrine, were used with conventional immunohistochemical techniques. a population of perikarya located at the outer margin of the inner nuclear layer (i ... | 1987 | 2891801 |
| overlap in the distribution of cholinergic and catecholaminergic neurons in the upper brainstem of the ferret. | the distribution of catecholaminergic and cholinergic neurons in the upper brainstem of the ferret were mapped by staining immunohistochemically two adjacent series of sections of brainstem for tyrosine hydroxylase and choline acetyltransferase, respectively. as in other species, large numbers of tyrosine-hydroxylase-positive neurons are localized in the ventral tegmental area (a10), the substantia nigra (a9), and in a8. tyrosine-hydroxylase-positive neurons in the dorsolateral pontine tegmentum ... | 1987 | 2892867 |
| effect of almitrine bismesylate on breathing pattern during hypoxia/hypercapnia in rats and ferrets. | 1. ventilatory measurements and functional residual capacity (frc) were recorded from anaesthetized rats and ferrets using a whole body plethysmograph. simulation of aspects of human chronic obstructive airways disease (coad) was attempted by making animals acutely hypoxic or hypoxic and hypercapnic by causing them to breath appropriate gas mixtures or by increasing the tracheal resistance or dead-space. some chronically hypoxic rats, which have muscularized pulmonary arterioles similar to coad ... | 1987 | 2896080 |
| two classes of ouabain binding sites in ferret heart and two forms of na+-k+-atpase. | in partially purified na+-k+-adenosinetriphosphatase (atpase) obtained from ferret heart, ouabain produced a monophasic inhibition curve; however, the curve spanned over 5 logarithmic units, indicating the presence of more than one classes of enzyme. [3h]ouabain binding studies revealed high-and low-affinity binding sites in approximately equal abundance, with apparent dissociation constants of 10 and 230 nm, respectively. sodium dodecyl sulfate-polyacrylamide gel electrophoresis of phosphoenzym ... | 1987 | 3034079 |
| cholinergic innervation of ferret visual system. | the distribution of acetylcholinesterase and choline acetyltransferase in primary visual areas of adult pigmented ferret was determined with cholinesterase histochemistry and choline acetyltransferase immunohistochemistry. in all visual areas the distribution of acetylcholinesterase in the neuropil closely matches that of choline acetyltransferase. in the cerebral cortex acetylcholinesterase and choline acetyltransferase are associated with axons found in every cortical layer and in the white ma ... | 1987 | 3035424 |
| hypoglycaemia due to a functional pancreatic islet cell tumour (insulinoma) in a ferret (mustela putorius furo). | 1987 | 3037763 | |
| relative abundance of two molecular forms of na+,k+-atpase in the ferret heart: developmental changes and associated alterations of digitalis sensitivity. | we have previously reported that adult ferret hearts have high affinity and low affinity ouabain-binding sites in approximately equal abundance corresponding, respectively, to alpha(+) and alpha subunits of na+,k+-atpase. in the present study, possible changes in relative abundance of the two molecular forms of na+,k+-atpase during postnatal development were examined. in 5-day-old or 7- to 10-day-old ferret heart, there was a predominance of the alpha form of na+,k+-atpase, the alpha(+)/alpha ra ... | 1987 | 3039337 |
| effect of upper respiratory infection on hearing in the ferret model. | in an effort to develop an adult animal model for acquired viral-induced hearing loss, three groups of mature ferrets were inoculated intranasally with respiratory viruses (influenza a/port chalmers, influenza b/mass, and parainfluenza i), which have been implicated as causative agents in idiopathic sudden hearing loss (ishl). all ferrets challenged with influenza a/port chalmers (a/pc) exhibited clinical signs of infection, but neither of the other two groups exhibited such signs. conductive an ... | 1987 | 3039863 |
| evidence for a multiple innervation of cerebellar purkinje cells by climbing fibers in adult ferrets infected at birth by a mink enteritis virus. | newborn ferrets were inoculated with mink enteritis virus (parvovirus). they developed a cerebellar hypoplasia and presented severe ataxia. electrophysiological study by intracellular recordings in the cerebellar cortex demonstrates that in these ferrets, like in other mammals, purkinje cells deprived from granule cell input during development remain multiply innervated by climbing fibers in the adult. | 1987 | 3040186 |
| bacterial adherence to the upper respiratory tract of ferrets infected with influenza a virus. | a ferret model was used to study bacterial adherence in animals with influenza. ferrets were inoculated intranasally with influenza a3/hong kong/1/68 virus. antiviral serum antibodies were apparent by day 5. on days 3, 5, 7, 9, and 11, three virus-inoculated and two uninoculated controls were anesthetized, exsanguinated, and decapitated, and the lower jaw was removed. each animal was inoculated intranasally with a 1-ml suspension containing 20 mg (dry wt) of either 3h-labeled staphylococcus aure ... | 1987 | 3554259 |
| spatial response properties of acoustically responsive neurons in the superior colliculus of the ferret: a map of auditory space. | extracellular single-unit recordings were made from auditory neurons in the superior colliculus of ferrets anesthetized with either a neuroleptic or a combination of barbiturate with paralysis. the response properties of these neurons were studied using white-noise bursts presented under free-field conditions in an anechoic chamber. auditory neurons were found throughout the intermediate and deep layers of the superior colliculus. all neurons were spontaneously active, the rates of discharge var ... | 1987 | 3559694 |
| a cage for the ferret. | a cage for ferrets is described that consists of a plastic box with a metal sliding-grill top and metal front lattice. it contains a new feeding system using dishes that can be removed without opening the cage. the cages are kept in mobile racks and are commercially available. | 1987 | 3560863 |
| intracellular [ca2+] related to rate of force development in twitch contraction of heart. | the relation between the rate of rise of tension (df/dt) and intracellular free ca2+ concentration ([ca2+]i) during twitch contraction was investigated in mammalian ventricular myocardium. [ca2+]i was assessed from luminescence emitted by ferret papillary muscles microinjected with the calcium-regulated photoprotein aequorin. evidence was found that during the phase of rising tension following maximum positive df/dt, there was an approximately linear relationship between df/dt at a given instant ... | 1987 | 3565592 |
| involvement of gastrointestinal mechano- and intestinal chemoreceptors in vagal reflexes: an electrophysiological study. | the role of gastrointestinal mechanoreceptors and intestinal chemoreceptors in the genesis of vago-vagal reflexes was assessed by recording single vagal efferent fibre discharge in the urethane-anaesthetized ferret during procedures known to activate discrete populations of gastrointestinal afferent fibres. distension of the stomach, duodenum and jejunum was used to activate mechanoreceptors while perfusion of the intestinal loops with various chemical solutions was used to activate mucosal chem ... | 1987 | 3571829 |
| behavioral correlates of hippocampal type 2 theta in the rat. | previous research has indicated that there are two types of theta activity which can be recorded from the hippocampus in most rodents. one type (type 1) of theta is correlated with voluntary movements while the second (type 2) occurs during immobility. a third waveform termed lia (large amplitude irregular activity) occurs during more automatic behaviors, e.g., grooming, shivering or immobility. in the rabbit and guinea pig type 2 theta can readily be elicited in unrestrained animals. however, t ... | 1987 | 3575499 |
| a study of spontaneous sexual maturation of the female ferret. | although ferrets are long-day breeders, females reared exclusively in nonstimulatory short days will undergo spontaneous sexual maturation by 30-50 wk of age. in the following report, this spontaneous sexual maturation of ferrets was studied to determine mechanisms regulating sexual maturation in nonstimulatory photoperiods. study of ovariectomized females treated with low, constant levels of estradiol suggest that a marked decrease in the efficacy of estradiol to inhibit luteinizing hormone sec ... | 1987 | 3580455 |
| developmental patterns of thyroid hormones and testosterone in ferrets. | plasma levels of thyroxine (t4) and triiodothyronine (t3) were measured in male and female ferrets at regular intervals between postnatal day 20 and 150 as well as in adult animals. in addition, testosterone level in male ferrets was measured. all hormones showed characteristic developmental patterns. there is a t4 maximum prior to a t3 maximum in subadult animals which in both cases surpasses adult levels. testosterone level shows a different developmental pattern. there is an outstanding peak ... | 1987 | 3583228 |
| retinal decussation patterns in pigmented and albino ferrets. | the decussation patterns of retinal ganglion cells in adult pigmented and albino ferrets were determined from the distribution of cells labelled after large unilateral injections of horseradish peroxidase into the visual pathway, involving the lateral geniculate nucleus and fibres of passage to the superior colliculus. about 6000 retinal ganglion cells project ipsilaterally in pigmented ferrets compared with only about 1500 in albino ferrets. in both strains, the vast majority of these cells (99 ... | 1987 | 3587608 |
| the effect of vasoactive intestinal peptide on smooth muscle tone and mucus secretion from the ferret trachea. | the effect of vasoactive intestinal peptide (vip) was examined on the smooth muscle contraction and mucus secretion produced by methacholine and phenylephrine in the ferret whole trachea in vitro. vip (0.5 to 800 nm) produced a concentration-dependent relaxation of the ferret trachea contracted by methacholine (1 microm) and phenylephrine (10 microm). the concentration-response curves for methacholine- and phenylephrine-induced contractions were both shifted to the right by vip (0.1 microm). met ... | 1987 | 3594072 |
| use-dependence of ryanodine effects on postrest contraction in ferret cardiac muscle. | during an investigation of the effect of ryanodine on contractions in cardiac muscle, it was found that long rest periods removed all or most of the drug's effect. therefore, we studied the kinetics of block development and recovery from block produced by low concentrations of ryanodine (1-100 pm) on the postrest contractions of ferret papillary muscle. at 100 pm, ryanodine depressed steady-state contraction amplitude slightly (4.2 +/- 1.1% mean +/- sem, n = 10) but strongly inhibited (40-80%) t ... | 1987 | 3594740 |
| investigation of the vagally induced changes in transmural potential difference in the ferret jejunum in vivo. | this study was designed to determine whether the non-cholinergic, non-adrenergic rise in transmural potential difference (pd), induced by vagal nerve stimulation is an efferent effect or one caused by the antidromic stimulation of afferent fibers. unilateral left supranodose vagotomy was performed, which caused degeneration of efferent fibers within the vagus nerve, leaving the nodose ganglion, and consequently afferent cell bodies, undamaged. after stimulating the unoperated nerve there was an ... | 1987 | 3598050 |
| contribution of auditory cortex to sound localization by the ferret (mustela putorius). | ferrets were tested in a semicircular apparatus to determine the effects of auditory cortical lesions on their ability to localize sounds in space. they were trained to initiate trials while facing forward in the apparatus, and sounds were presented from one of two loudspeakers located in the horizontal plane. minimum audible angles were obtained for three different positions, viz., the left hemifield, with loudspeakers centered around -60 degrees azimuth; the right hemifield, with loudspeakers ... | 1987 | 3598629 |