Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| Modelling and Bioinformatics Analysis of the Dimeric Structure of House Dust Mite Allergens from Families 5 and 21: Der f 5 Could Dimerize as Der p 5. | Allergy represents an increasing thread to public health in both developed and emerging countries and the dust mites Dermatophagoides pteronyssinus (Der p), Blomia tropicalis (Blo t), Dermatophagoides farinae (Der f), Lepidoglyphus destructor (Lep d) and Suidasia medanensis (Sui m) strongly contribute to this problem. Their allergens are classified in several families among which families 5 and 21 which are the subject of this work. Indeed, their biological function as well as the mechanism or e ... | 2012 | 22208271 |
| impact of atopy on asthma and allergic rhinitis in the cohort for reality and evolution of adult asthma in korea. | atopy is an important cause of asthma. few data on the prevalence of atopy or comparisons with clinical characteristics of asthma in korean patients have been published. we evaluated the effects of atopy on clinical profiles and airway inflammation in korean asthmatics. | 2012 | 23638312 |
| effect of germicidal uv-c light(254 nm) on eggs and adult of house dustmites, dermatophagoides pteronyssinus and dermatophagoides farinae (astigmata: pyroglyhidae). | to examined the immediate and 24 hours post- irradiation germicidal effects of uv-c lamp on eggs and adults of house dust mites dermatophagoides pteronyssinus (d. pteronyssinus) and dermatophagoides farinae (d. farinae). | 2012 | 23569994 |
| [study of tacrolimus intranasal treatment for allergic asthma in mice]. | to explore the efficacy of intranasal treatment by immunosuppressant tacrolimus for allergic asthma and its mechanism in mice. | 2012 | 23484272 |
| [analysis on the allergens in allergic rhinitis patients in changzhou district of jiangsu]. | to investigate the distribution of positive allergens in patients with allergic rhinitis in changzhou. | 2012 | 23451473 |
| [house dust mite allergy--living with the invisible roommates]. | house dust mites are the most common sources of allergic sensitization, primarily responsible for the occurrence of various clinical forms of respiratory and skin allergies, but also of certain forms of food allergy. there are many various mite species, of which only a small number are constantly or occasionally found in house dust samples. mites from pyroglyphidae family, dermatophagoides pteronyssinus and dermatophagoides farinae are most frequently responsible for sensitization of susceptible ... | 2012 | 23437635 |
| mite fauna and mite antigen detection in house dust found in residential areas in los baños, laguna, philippines. | dust mites are a medically important group of animals commonly found in carpets and mattresses in houses. antigens in their feces cause allergic reactions such as asthma and contact dermatitis. dust samples were vacuum-collected in a special collecting bag from a one square meter area of living room floors of 100 randomly sampled houses in los baños, laguna, philippines for one minute. chromato-immunoassay elisa (mitey checker) was used to detect mite antigenicity. twenty-three species of mites ... | 2012 | 23431817 |
| ykl-40 in induced sputum after allergen bronchial provocation in atopic asthma. | serum chitinase-like proteins such as ykl-40 in asthmatic patients are known to positively correlate with disease severity but controversy remains regarding their role. the allergen bronchial provocation test (abpt) can induce allergic airway inflammation in individuals with atopic asthma. | 2012 | 23397672 |
| allergic sensitization frequency and wheezing differences in early life between black and white children. | asthma is more common in black children than in white children. allergic sensitization has been shown to be associated with increased likelihood of asthma. this study was designed to determine whether there are racial differences in the allergens to which children are sensitized in the detroit metropolitan area and determine whether sensitization was associated with wheeze outcomes. pregnant women were recruited for the wayne county health, environment, allergy, and asthma longitudinal study bir ... | 2012 | 23394507 |
| [allergen analysis on patients with allergic rhinitis in lanzhou]. | to investigate the effective clinical diagnosis and treatment for allergic rhinitis (ar) by examining the allergens and dietary habits of the patients. | 2012 | 23328046 |
| domestic mite antigens in floor and airborne dust at workplaces in comparison to living areas: a new immunoassay to assess personal airborne allergen exposure. | allergens produced by domestic mites (dm) are among the most common allergic sensitizers and risk factors for asthma. to compare exposure levels between workplaces and living areas a new assay able to measure airborne dm antigen concentrations was developed. | 2012 | 23285240 |
| [efficacy and safety of sublingual immunotherapy with house dust mite extract in poly allergen sensitized children with allergic rhinitis]. | to compare the efficacy of sublingual immunotherapy (slit) with standardized house dust mite extract in mono sensitized and polysensitized children with allergic rhinitis. | 2012 | 23272490 |
| irradiation of light emitting diode at 850nm inhibits t cell-induced cytokine expression. | an anti-inflammatory effect of light obtained from light-emitting diodes (leds) has been discovered, however, limited ranges of wavelengths have been used and the action mechanism has been rarely demonstrated. | 2012 | 22104195 |
| effect of respiratory syncytial virus infection on plasmacytoid dendritic cell regulation of allergic airway inflammation. | respiratory syncytial virus (rsv) can infect myeloid dendritic cells (mdcs) and regulate their function in the development of allergy. it has been widely reported that plasmacytoid dcs (pdcs) play a critical role in antiviral innate immunity. in contrast, not much is known about the role of pdcs in the interaction between allergy and viral infection. the purpose of the present study was to investigate the effect of rsv infection on pdc function in the regulation of allergic airway inflammation i ... | 2012 | 21894025 |
| sensitization and allergic histories differ between black and white pregnant women. | racial differences in allergic diseases have been reported, with black subjects suffering disproportionately compared with white subjects, although such studies have been more commonly done in pediatric populations. | 2012 | 22857795 |
| ige cross-reactivity between house dust mite allergens and ascaris lumbricoides antigens. | common antigens between intestinal parasites and environmental allergens may play a role in the modulation of allergic immune responses. there is a growing interest in investigating cross-reactivity between common helminths and dust mites affecting humans, particularly in the tropics. | 2012 | 22348205 |
| regulation of dendritic cell functions against harmful respiratory pathogens by a cysteinyl leukotrienes receptor antagonist. | cysteinyl leukotriene receptor antagonist (ltra) is a widely used medicine for asthma. cysteinyl leukotrienes (cyslts) are involved in the regulation of dendritic cell (dc) function. however, the effects of ltra on dc-related antimicrobial immunity against harmful respiratory pathogens remain unknown. the purpose of this study was to examine the effects of ltra administered in vivo on dc function against representative respiratory pathogens in vitro. pulmonary dcs were isolated from four groups ... | 2012 | 22852127 |
| transcripts of a heterologous gene encoding mite allergen der f 7 are stabilized by codon optimization in aspergillus oryzae. | we have previously demonstrated that transcripts of an at-biased heterologous gene encoding mite allergen der f 7 from dermatophagoides farinae were polyadenylated prematurely within the coding region when native cdna was expressed in aspergillus oryzae, and that this premature polyadenylation was prevented by the codon optimization of the der f 7 gene, resulting in increased steady-state mrna levels. in this study, we tested the stability of transcription products derived from expression constr ... | 2012 | 22644529 |
| specific immunoglobulin e antibodies to saprophytic yeasts in sera of atopic patients allergic to house dust mites. | atopic dermatitis (ad) is a complex disease caused by genetic and environmental interactions. ad impairs skin barrier function, enabling microorganisms to penetrate and interact with the immune system. | 2012 | 23101185 |
| measurement for canine ige using canine recombinant high affinity ige receptor α chain (fcεriα). | to detect allergen-specific ige in dogs with allergic diseases, we developed a recombinant canine high affinity ige receptor α chain (fcεriα)-based ige detection system. using the recombinant protein of canine fcεriα expressed by an escherichia coli expression system, we could detect house dust mite (dermatophagoides farinae) allergen-specific ige in sera from dogs naturally and experimentally sensitized to this allergen with elisa and western blotting. the ige binding activity of recombinant ca ... | 2012 | 22322186 |
| early exposure to probiotics in a canine model of atopic dermatitis has long-term clinical and immunological effects. | probiotics modulate the immune response and may have protective effects against atopic dermatitis (ad). clinical trials using dogs with spontaneous disease are limited by confounding factors such as different diets, environments and sensitizations while a more controlled evaluation is possible using experimental models. a validated model of canine ad showed that early exposure to lactobacillus rhamnosus gg (lgg) significantly decreases allergen-specific ige and partially prevents ad in the first ... | 2012 | 22436376 |
| diet influences growth rates and allergen and endotoxin contents of cultured dermatophagoides farinae and dermatophagoides pteronyssinus house dust mites. | the house dust mites dermatophagoides farinae and dermatophagoides pteronyssinus are cultured to obtain material for the production of allergen extracts for research, diagnostic and immunotherapeutic purposes. | 2012 | 22722476 |
| multiplex pcr for identifying common dust mites species (dermatophagoides pteronyssinus, dermatophagoides farinae and blomia tropicalis). | dust mites are known to be an important source of inhalant allergens causing allergic rhinitis and asthma worldwide. the sizes of dust mite populations in patients' houses are useful to monitor the risk of allergen exposure. however, mite identification using the conventional microscopic technique requires specific expertise and is time consuming; therefore a molecular technique has been developed in order to solve these drawbacks. | 2012 | 23156853 |
| indoor mite allergen levels, specific ige prevalence and ige cross-inhibition pattern among asthmatic children in haikou, southern china. | haikou locates in tropical island with unique mite propagation. the aim of this stuy is to determine mite allergens levels in haikou, and to investigate the prevalence of mite specific ige-sensitization and ige cross-reactivity between house dust mites. | 2012 | 22932181 |
| dust mite species in the households of mite-sensitive dogs with atopic dermatitis. | the presence of important house dust and storage mite species in the microenvironment of atopic dogs has not been thoroughly investigated. | 2012 | 22575020 |
| cloning, bioinformatics analysis, and expression of the dust mite allergen der f 5 of dermatophagoides farinae. | crude extracts of house dust mites are used clinically for diagnosis and immunotherapy of allergic diseases, including bronchial asthma, perennial rhinitis, and atopic dermatitis. however, crude extracts are complexes with non-allergenic antigens and lack effective concentrations of important allergens, resulting in several side effects. dermatophagoides farinae (hughes; acari: pyroglyphidae) is one of the predominant sources of dust mite allergens, which has more than 30 groups of allergen. the ... | 2012 | 22584646 |
| [investigation of skin prick test on 2707 patients with allergic rhinitis in wuhan area]. | to investigate the distribution of common allergens in patients with allergic rhinitis (ar) from 2006 to 2010 in wuhan area, and provide the objective evidence for the prevention and treatment of ar. | 2012 | 23141402 |
| [clinical significance of skin prick test for inhalant allergens in 3085 children with allergic diseases]. | to investigate the main inhalant allergens and their distribution patterns in children with allergic diseases from xi'an and the surrounding area and to provide evidence for the prevention and treatment of allergic diseases in children. | 2012 | 23092566 |
| sensitization rates of airborne pollen and mold in children. | aeroallergens are important causative factors of allergic diseases. previous studies on aeroallergen sensitization rates investigated patients groups that had visited pediatric allergy clinics. in contrast, we investigated sensitization rates in a general population group of elementary school to teenage students in incheon, jeju, and ulsan. | 2012 | 23049589 |
| [evaluation of exposure and sensitization to house dust mites among rhinitis patients in the steppe environment of inner mongolia]. | to evaluate the correlation of exposure and sensitization to house dust mites among rhinitis patients, and the consistency of skin prick test (spt) and serum specific ige (sige) in the detection of sensitization in a steppe environment of inner mongolia. | 2012 | 22455768 |
| contact and fumigant toxicities of 3-methylphenol isolated from ostericum koreanum and its derivatives against house dust mites. | the acaricidal activities of an active constituent derived from ostericum koreanum roots and its derivatives were determined using fumigant and direct-contact toxicity bioassays against dermatophagoides farinae and dermatophagoides pteronyssinus . this was compared with that of a commercial acaricide (benzyl benzoate). in the fumigant toxicity bioassay, 4-chloro-6-isopropyl-3-methylphenol (0.29 μg/cm(2)) was 37.17 times more effective than benzyl benzoate (10.78 μg/cm(2)) against d. farinae, fol ... | 2012 | 23194135 |
| [correlation of serum eosinophil cationic protein with the severity of allergic rhinitis in childhood]. | to investigate the relationships between the severity of childhood allergic rhinitis (ar) and the peripheral blood eosinophil count, serum eosinophil cationic protein (ecp), total ige (tige), and allergen-specific ige (sige) levels. | 2012 | 23141391 |
| dermatophagoides farinae house dust mite allergen challenges reduce stratum corneum ceramides in an experimental dog model of acute atopic dermatitis. | ceramides are essential stratum corneum (sc) lipids and they play a pivotal role in maintaining effective cutaneous barrier function. | 2012 | 23140315 |
| standardization of house dust mite extracts in korea. | house dust mites are the most important cause of respiratory allergy in korea. standardization of allergen extracts is essential for improving diagnostics and immunotherapeutics. this study was undertaken to evaluate the allergenicity of standardized house dust mite allergen extracts from korean house dust mite isolates. | 2012 | 23115731 |
| house dust mite allergy in korea: the most important inhalant allergen in current and future. | the house-dust mite (hdm), commonly found in human dwellings, is an important source of inhalant and contact allergens. in this report, the importance of hdm allergy in korea and the characteristics of allergens from dust mite are reviewed with an emphasis on investigations performed in korea. in korea, dermatophagoides farinae is the dominant species of hdm, followed by d. pteronyssinus. tyrophagus putrescentiae is also found in korea, but its role in respiratory allergic disease in korea is co ... | 2012 | 23115727 |
| establishment of two novel elisa methods for dermatophagoides farinae-specific ige detection with recombinant group 2 allergen. | dermatophagoides farinae, or the american house dust mite, is a common cause of allergy and asthma. current tests for sensitization to d. farinae include an indirect enzyme-linked immunosorbent assay (elisa) method for specific ige detection, which, while clinically useful, is time-consuming and has low sensitivity since it uses crude mite extracts. we developed two new elisa methods to detect the group 2 allergen from d. farinae (der f 2) and the der f 2-specific ige in sera of patients with as ... | 2012 | 23090735 |
| validation of a novel epicutaneous delivery system for patch testing of house dust mite-hypersensitive dogs. | patch tests with allergens are used for the evaluation of cellular hypersensitivity to food and environmental allergens in dogs and humans with atopic dermatitis. viaskin is a novel allergen epicutaneous delivery system that enhances epidermal allergen capture by immune cells. | 2012 | 23050930 |
| [therapeutic approach to mite-induced intractable dermatitis using novel immunomodulator fty720 (fingolimod) in combination with betamethasone ointment in nc/nga mice]. | the increasing incidence and prevalence of atopic dermatitis (ad) have led to a requirement for new means to treat the disease. we investigated the therapeutic efficacy of the novel immunomodulator fty720 (fingolimod), alone and in combination with betamethasone valerate ointment, in the nc/nga mouse model of mite-induced intractable dermatitis. | 2012 | 23007332 |
| cysteinyl leukotriene 2 receptor on dendritic cells negatively regulates ligand-dependent allergic pulmonary inflammation. | cysteinyl leukotrienes (cys-lts) can mediate th2 immunity to the house dust mite, dermatophagoides farinae, via the type 1 receptor cyslt(1)r on dendritic cells (dcs). however, the role of the homologous type 2 receptor cyslt(2)r in th2 immunity is unknown. d. farinae sensitization and challenge of cyslt(2)r-deficient mice showed a marked augmentation of eosinophilic pulmonary inflammation, serum ige, and th2 cytokines. wild-type (wt) mice sensitized by adoptive transfer of d. farinae-pulsed cys ... | 2012 | 23002438 |
| topical application of an ethanol extract prepared from illicium verum suppresses atopic dermatitis in nc/nga mice. | illicium verum is a traditional herbal medicine with anti-inflammatory properties used in asia. however, its usefulness in the treatment of allergic diseases remains unclear. this study evaluated the anti-inflammatory and antiallergic effects of i. verum extract (ive) in a mouse model of atopic dermatitis. | 2012 | 22971899 |
| crystal structure of der f 7, a dust mite allergen from dermatophagoides farinae. | der f 7 is the group 7 allergen from the dust mite dermatophagoides farinae, homologous to the major allergen der p 7 from d. pteronyssinus. monoclonal antibody that bind to residues leu48 and phe50 was found to inhibit ige binding to residue asp159, which is important for the cross-reactivity between der f 7 and der p 7. | 2012 | 22970319 |
| efficacy and safety of sublingual immunotherapy in asian children. | sublingual immunotherapy is currently accepted as a suitable alternative to subcutaneous immunotherapy because of its easy and painless administration and improved safety. many clinical trials have demonstrated that sublingual immunotherapy is an effective and safe treatment for pollen or mite allergic rhinitis. however, there have been very few studies overall on children with allergic rhinitis who are sensitized to house-dust mites in asia. the purpose of the present study was to investigate t ... | 2012 | 22959336 |
| racial disparities in allergic outcomes in african americans emerge as early as age 2 years. | racial disparities in allergic disease outcomes have been reported with african americans suffering disproportionately compared to white individuals. | 2012 | 22909162 |
| [efficacy of specific sublingual immunotherapy with dermatophagoides farinae drops in the treatment of cough variant asthma in children]. | to study the efficacy and safety of specific sublingual immunotherapy with dermatophagoides farinae drops in the treatment of cough variant asthma in children. | 2012 | 22898278 |
| the effect of stimuli on basophil-mediated atopic responses during asthmatic lying-in women and in newborns. | morbidity from allergic diseases is increasing. basophils play a critical role in systemic anaphylaxis and chronic allergic inflammation. the prenatal environment must be regarded as a possible early risk factor for allergic diseases in children. our objective was to determine if basophils harvested from neonates genetically predisposed to atopic disease had different levels of cd63 expression and il-4 release properties in response to various stimuli (peptidoglycan, dermatophagoides farinae, hy ... | 2012 | 22894778 |
| essential oil components from asarum sieboldii miquel are toxic to the house dust mite dermatophagoides farinae. | in our effort to develop novel plant-derived acaricides, we examined the contact and fumigant toxicity of asarum heterotropoides (asarum sieboldii miquel) essential oil constituents to the house dust mite dermatophagoides farinae (acari: pyroglyphidae). ten constituents, including methyl eugenol (relative amount 42.18 %), were identified by gas chromatography-mass spectroscopy (gc-ms) in the a. sieboldii miq. essential oil. in contact toxicity tests, methyl eugenol (4.2 μg/cm(2), 24 h ld50) was ... | 2012 | 22833176 |
| winter season temperature drops and sulfur dioxide levels affect on exacerbation of refractory asthma in south korea: a time-trend controlled case-crossover study using soonchunhyang asthma cohort data. | according to the american thoracic society, approximately 5% of all asthmatics have refractory asthma (ra); these patients fail to recover lost lung function even after long-term treatment with high doses of medications. | 2012 | 22812434 |
| [allergens and their relationships to childhood bronchial asthma in the jiading district of shanghai]. | to study allergens and their relationship to the occurrence of childhood bronchial asthma in the jiading district of shanghai. | 2012 | 22809606 |
| total ige and allergen-specific ige and igg antibody levels in sera of atopic dermatitis affected and non-affected labrador- and golden retrievers. | canine atopic dermatitis (cad) is an allergic skin disease associated with ige and igg antibodies (ab) to environmental allergens. the aim of this study was to determine which other factors influence serum ab levels in cad-affected and non-affected dogs as this has only been poorly investigated in dogs so far. total and allergen-specific ige levels and dermatophagoides farinae (df)-specific igg1 and igg4 were measured by elisa in sera of 145 cad-affected and 271 non-affected labrador- and golden ... | 2012 | 22739207 |
| [skin prick testing versus immumofluorescence testing for mites allergens]. | to discuss the characteristics of skin prick test (spt) and immumofluorescence method (ifm) in detecting the atopy of dermatophagoides pteronyssinus (dp) and dermatophagoides farinae (df)and explore the relationship of them. | 2012 | 22667132 |
| climatic factors correlate with innate immune response in children with dermatophagoides farinae-induced allergic asthma. | to determine the effect of climatic factors on immune markers in children with dermatophagoides farinae induced asthma. | 2012 | 22613438 |
| [analyzing of the inhaled allergens profiles of 890 allergic rhinitis patients]. | to investigate the inhaled allergens spectrum of 890 allergic rhinitis patients in shanghai, and to provide basic epidemiologic information for the prevention and treatment of allergic rhinitis. | 2012 | 22568255 |
| limonene inhalation reduces allergic airway inflammation in dermatophagoides farinae-treated mice. | limonene is one of the main flavonoids which is reported to inhibit the inflammatory response by suppressing the production of reactive oxygen species. the aim of this study was to evaluate whether limonene can inhibit dermatophagoides farinae-induced airway hyperresponsiveness (ahr), eosinophilic infiltration and other histological changes in the lung, t helper (th) 2 cytokine production and airway remodeling in a mice model of asthma. treatment with limonene significantly reduced the levels of ... | 2012 | 22564095 |
| prevention and treatment of allergic inflammation by an fcγ-der f2 fusion protein in a murine model of dust mite-induced asthma. | the immunoglobulin e (ige) high-affinity receptor fcεri expressed on mast cells and basophils plays a critical role in triggering allergic disease. the co-aggregation of the fcεri and fcγriib receptors is inhibitory to fcεri signaling and holds great potential for the treatment of ige-mediated allergies. in china, dermatophagoides farinae is a common anaphylaxis trigger. therefore, in this study, the fcγriib-mediated immunomodulating activity of recombinant fcγ-der f2 fusion protein was tested i ... | 2012 | 22539132 |
| acetaldehyde at a low concentration synergistically exacerbates allergic airway inflammation as an endocrine-disrupting chemical and as a volatile organic compound. | acetaldehyde is an endocrine-disrupting chemical (edc) and a volatile organic compound (voc). it is also a carcinogen and teratogen that causes bronchoconstriction in a subset of asthmatics. however, the mechanism through which acetaldehyde acts as an edc/voc causing allergic airway inflammation remains unknown. | 2012 | 22538484 |
| [results of skin prick test in young children with wheezing or allergic diseases]. | to study the characteristics of allergic reactions to common aeroallergens in young children with wheezing or allergic diseases by examining the results of skin prick test in children under 5 years old. | 2012 | 22537958 |
| sequence polymorphisms of der f 1, der p 1, der f 2 and der p 2 from korean house dust mite isolates. | amino acid sequence variations have possible influences on the allergenicity of allergens and may be important factors in allergen standardization. this study was undertaken to investigate the sequence polymorphisms of group 1 and 2 allergens from korean isolates of the house dust mites dermatophagoides farinae and d. pteronyssinus. cdna sequences encoding group 1 and 2 allergens were amplified by rt-pcr and compared the deduced amino acid sequences. der f 1.0101, which appeared in 64.0 % of the ... | 2012 | 22535483 |
| the translational repressor t-cell intracellular antigen-1 (tia-1) is a key modulator of th2 and th17 responses driving pulmonary inflammation induced by exposure to house dust mite. | t-cell intracellular antigen-1 (tia-1) is a translational repressor that dampens the production of proinflammatory cytokines and enzymes. in this study we investigated the role of tia-1 in a mouse model of pulmonary inflammation induced by exposure to the allergenic extract (df) of the house dust mite dermatophagoides farinae. when intranasally challenged with a low dose of df, mice lacking tia-1 protein (tia-1(-/-)) showed more severe airway and tissue eosinophilia, infiltration of lung broncho ... | 2012 | 22525013 |
| ras guanine nucleotide-releasing protein-4 (rasgrp4) involvement in experimental arthritis and colitis. | rasgrp4 (ras guanine nucleotide-releasing protein-4) is an intracellular, calcium-regulated guanine nucleotide exchange factor and diacylglycerol/phorbol ester receptor expressed in mast cells (mcs) and their progenitors. to study the function of this signaling protein in inflammatory disorders, a homologous recombination approach was used to create a rasgrp4-null c57bl/6 mouse line. the resulting transgenic animals had normal numbers of mcs in their tissues that histochemically and morphologica ... | 2012 | 22511759 |
| acaricidal activities of the active component of lycopus lucidus oil and its derivatives against house dust and stored food mites (arachnida: acari). | recent studies have focused on materials derived from plant extracts as mite control products against house dust and stored food mites because repeated use of synthetic acaricides had led to resistance and unwanted activities on non-target organisms. the aim of this study was to evaluate the acaricidal activity of materials derived from lycopus lucidus against dermatophagoides farinae, d. pteronyssinus and tyrophagus putrescentiae. | 2012 | 22500291 |
| contact blepharoconjunctivitis due to black henna--a case report. | para-phenylenediamine (ppd) can induce immediate or - more often - delayed hypersensitivity. we report the case of 48-year old female admitted to the out-patient allergy clinic a day after her visit in a beauty parlour, where she had her eyelashes and eyebrows dyed with henna. physical examination revealed prominent edema of the upper part of the face including forehead, cheeks and eyes causing severe narrowing of the palpebral chink. skin prick tests (spt) with common allergens were positive fo ... | 2012 | 22492286 |
| angelicae dahuricae radix inhibits dust mite extract-induced atopic dermatitis-like skin lesions in nc/nga mice. | we examined whether angelicae dahuricae radix (ar) suppresses the development of atopic dermatitis (ad)-like skin lesions induced by dermatophagoides farinae in nc/nga mice. to investigate the effect of ar, we measured the ad severity score, measured plasma levels of ige and histamine, and performed histological analysis in nc/nga mice. we also confirmed the anti-inflammatory effects of ar by measuring tarc/ccl17 production from lps-treated raw 264.7 cells and mrna levels of tarc and mdc/ccl22 i ... | 2012 | 22454682 |
| production of gm-csf mediated by cysteine protease of der f in canine keratinocytes. | house dust mite (hdm) allergens are the most common allergens for induction of ige-mediated hypersensitivity. recently, epicutaneous sensitization with hdm allergens has been emphasized in the development of atopic dermatitis (ad) by producing various soluble factors in keratinocytes. among the soluble factors, gm-csf is a key molecule that activates langerhans cells, antigen-presenting cells in the epidermis. in the present study, we investigated the effects of dermatophagoides farinae (der f) ... | 2012 | 22446400 |
| evaluation of eosinophilic inflammation in a novel murine atopic keratoconjunctivitis model induced by crude dermatophagoides farinae antigen. | the purpose of this study is to conduct a histopathological research of the conjunctival findings and eosinophilic inflammation of novel atopic keratoconjunctivitis in a nc/nga mouse model using crude dermatophagoides farina. | 2012 | 22441637 |
| acaricidal toxicity of 2'-hydroxy-4'-methylacetophenone isolated from angelicae koreana roots and structure-activity relationships of its derivatives. | the acaricidal activities of 2'-hydroxy-4'-methylacetophenone derived from angelica koreana roots and its derivatives against dermatophagoides farinae, dermatophagoides pteronyssinus, and tyrophagus putrescentiae were examined by vapor phase and contact toxicity bioassays. in the vapor phase toxicity bioassay, 2'-methylacetophenone (1.25 μg/cm(2)) was 8.0 times more toxic against d. farinae than benzyl benzoate (10.00 μg/cm(2)), followed by 3'-methylacetophenone (1.26 μg/cm(2)), 4'-methylacetoph ... | 2012 | 22429095 |
| dna/amphiphilic block copolymer nanospheres reduce asthmatic response in a mouse model of allergic asthma. | asthma is a chronic, inflammatory, respiratory disease caused by an abnormal reactivity against allergens. the most promising treatments for asthma are based on specific immunotherapies, but they lack efficiency and can induce deleterious side effects. among new modalities of immunotherapy currently in development, dna vaccination presents a promising approach, as it enables targeted immunotherapy in association with reduced allergenicity. we have developed an innovative, dna-based vaccine again ... | 2012 | 22429072 |
| dermatophagoides in childhood asthma. allergy to dermatophagoides associates more severe childhood asthma with a potential role for acaricides. | to evaluate hypersensitivity to dermatophagoides pteronyssinus (d. pteronyssinus) and dermatophagoides farinae (d. farinae) in pediatric patients with asthma, and the use of acaricides. | 2012 | 22426910 |
| interference in foraging behaviour of european and american house dust mites dermatophagoides pteronyssinus and dermatophagoides farinae (acari: pyroglyphidae) by catmint, nepeta cataria (lamiaceae). | the european and american house dust mites, dermatophagoides pteronyssinus and d. farinae, have a huge impact upon human health worldwide due to being the most important indoor trigger of atopic diseases such as asthma, rhinitis and atopic dermatitis. preceding studies have shown that the behavioural response of house dust mites towards volatile chemicals from food sources can be assessed using a y-tube olfactometer assay. in the current study, we used this assay to investigate, for the first ti ... | 2012 | 22382713 |
| topically applied semaphorin 3a ointment inhibits scratching behavior and improves skin inflammation in nc/nga mice with atopic dermatitis. | epidermal hyperinnervation in atopic dermatitis (ad) is activated directly by various external stimuli, causing enhanced itching. nerve density is regulated by the nerve repulsion factor semaphorin 3a (sema3a), along with nerve elongation factors. | 2012 | 22381253 |
| acaricidal activity of dhemh, derived from patchouli oil, against house dust mite, dermatophagoides farinae. | this study characterized the acaricidal activity of constituents of patchouli oil extracted from (pogostemon cablin (blanco) benth) against the house dust mite, dermatophagoides farinae. a new compound, 2-(1,3-dihydroxy-but-2-enylidene)-6-methyl-3-oxo-heptanoic acid (dhemh), was isolated from patchouli oil and characterized by (1)h-nmr, (13)c-nmr, lc-ms and elemental analysis (ea). this active component was identified as the hydrolysate of pogostone. fifteen other constituents found in patchouli ... | 2012 | 22293476 |
| effect of a commercial air ionizer on dust mites dermatophagoides pteronyssinus and dermatophagoides farinae (acari: pyroglyphidae) in the laboratory. | to investigate the short and long term efficacy of a commercial air ionizer in killing dermatophagoides pteronyssinus (d. pteronyssinus) and dermatophagoides farinae (d. farinae) mites. | 2012 | 23569888 |
| [the benefits of using basophil activation test as a diagnostic tool prior to specific immunotherapy with inhalant allergens]. | routine qualification for specific immunotherapy (sit) is based on clinical history and skin prick tests (spt) or specific ige (sige). in cases of discordance between these two, basophil activation test (bat) may be decisive. the aim of the present study was to determine the specificity and sensitivity of bat, sige, and spt, and to analyse cases, in which clinical data and spt alone would result in wrongful qualification for sit. | 2012 | 23750433 |
| efficacy and safety of a once-daily sublingual immunotherapy without escalation regimen in house dust mite-induced allergic rhinitis. | the conventional escalation regimen for sublingual immunotherapy (slit) in patients with allergic rhinitis has been proven to be safe and successful in reducing allergic symptoms. however, few studies compared the efficacy and safety between a conventional escalation regimen for slit and once-daily slit. the aim of the present study was to compare the efficacy and safety of once-daily slit without escalation (slitse) to conventional escalation therapy (slitwe). | 2013 | 23044892 |
| population growth and allergen accumulation of dermatophagoides farinae cultured at 20 and 25 °c. | house dust mites are cultured to obtain mite allergen material to produce allergen extracts (vaccines) for diagnostic tests, immunotherapy, and research purposes. research laboratories and manufacturers have their own culturing protocols to grow these mites and these may vary between manufacturers and between research laboratories. the temperature at which mites are cultured may influence the allergen composition, allergen ratio of der 1: der 2 and endotoxin levels in the extracts produced from ... | 2013 | 23070476 |
| contact and fumigant toxicity of pinus densiflora needle hydrodistillate constituents and related compounds and efficacy of spray formulations containing the oil to dermatophagoides farinae. | the toxicity of red pine needle hydrodistillate (rpn-hd), 19 rpn-hd constituents and another 12 structurally related compounds and the control efficacy of four experimental spray formulations containing rpn-hd (0.5. 1, 2 and 3% sprays) to adult dermatophagoides farinae were evaluated. | 2013 | 23109302 |
| a genome-wide association study of total serum and mite-specific iges in asthma patients. | immunoglobulin e (ige) is one of the central players in asthma and allergic diseases. although the serum ige level, a useful endophenotype, is generally increased in patients with asthma, genetic factors influencing ige regulation in asthma are still not fully understood. to identify the genetic variations associated with total serum and mite-specific iges in asthmatics, a genome-wide association study (gwas) of 657,366 single nucleotide polymorphisms (snps) was performed in 877 korean asthmatic ... | 2013 | 23967269 |
| the effect of montelukast on wheal reactions in skin prick tests: a double-blind-placebo-controlled randomized trial. | it is well-known that number of drugs may interfere with wheal reactions in skin prick test. however, the effect of long-term use of montelukast, a cystenil leukotriene receptor antagonist, on skin prick test hasn't been full elucidated. the aim of present study was to demonstrate the effect of montelukast on skin prick tests (spt). | 2013 | 23958393 |
| pcr detection of the 14.5 antibacterial nlpc/p60-like dermatophagoides pteronyssinus protein in dermatophagoides farinae (acari: pyroglyphidae). | house dust mites produce antibacterial proteins suppressing bacterial growth. the 14.5-kda bacteriolytic protein (uniprotkb q8mwr6) has been known in dermatophagoides pteronyssinus trouessart. we have applied polymerase chain reaction and reverse transcription-pcr to detect a homologous gene sequence coding for a q8mwr6-related protein in dermatophagoides farinae (hughes) using genomic dna and total rna, respectively. the resulting pcr product of expected size, 243 bp, was obtained from both der ... | 2013 | 23926795 |
| a case of mite-ingestion-associated exercise- induced anaphylaxis mimicking wheat-dependent exercise-induced anaphylaxis. | we present a case of mite-ingestion-associated exercise-induced anaphylaxis mimicking wheat-dependent exercise-induced anaphylaxis (wdeia). a 17-year-old boy was referred for an episode of anaphylaxis while jogging, 1.5 h after having eaten okonomiyaki (a japanese pancake). laboratory measures revealed a slightly elevated specific immunoglobulin e (ige) antibody against omega-5 gliadin (0.41 kua/l) and a marked elevation of specific ige antibody against house-dust mite, dermatophagoides farinae ... | 2013 | 23921625 |
| sublingual immunotherapy in children with allergic rhinoconjunctivitis mono-sensitized to house-dust-mites: a double-blind-placebo-controlled randomised trial. | although sublingual immunotherapy (slit) has been demonstrated to be a safe and efficient treatment in children with seasonal allergic rhinitis (ar), there is little evidence on the efficacy of slit with house-dust-mite (hdm) extract in children with isolated perennial ar. | 2013 | 23886432 |
| [comparison of serum specific ige and skin prick test in allergic rhinitis patients sensitive to dust mite]. | to investigate the correlation of serum specific ige and skin prick test in allergic rhinitis patients sensitive to dust mite and the difference between the results. | 2013 | 23858721 |
| 850nm light-emitting-diode phototherapy plus low-dose tacrolimus (fk-506) as combination therapy in the treatment of dermatophagoides farinae-induced atopic dermatitis-like skin lesions in nc/nga mice. | light emitting diode (led) phototherapy is an effective alternative for the treatment of inflammatory skin disorders. tacrolimus (fk-506) is a potent immunomodulating agent, which has been used to treat ad. combination therapy is often used in the treatment of ad to improve therapeutic efficacy or to reduce the dose of each drug. | 2013 | 23810774 |
| polydesensitisation with reducing elevated serum total ige by ifn-gamma therapy in atopic dermatitis: ifn-gamma and polydesensitisation (pds). | ad patients exhibit sensitisation to multiple allergens due to a th1/th2 imbalance. until now, it was impossible to improve the polysensitised status and elevated serum total ige levels. in this study, the effects of ifn-gamma on systemic polysensitisation to multiple allergens and on serum total ige levels are investigated. | 2013 | 23786862 |
| rutin suppresses atopic dermatitis and allergic contact dermatitis. | atopic dermatitis (ad) and allergic contact dermatitis (acd) is a common allergic inflammatory skin disease caused by a combination of eczematous, scratching, pruritus and cutaneous sensitization with allergens. the aim of our study was to examine whether rutin, a predominant flavonoid having anti-inflammatory and antioxidative potential, modulates ad and acd symptoms. we established an atopic dermatitis model in balb/c mice by repeated local exposure of house dust mite (dermatophagoides farinae ... | 2013 | 23760007 |
| acaricidal toxicities of 1-hydroxynaphthalene from scutellaria barbata and its derivatives against house dust and storage mites. | the essential oil of scutellaria barbata was extracted using a steam distillation and then evaluated via fumigant and contact toxicity bioassays against dermatophagoides farinae, dermatophagoides pteronyssinus, and tyrophagus putrescentiae. the acaricidal toxicities of 1-hydroxynaphthalene from s. barbata oil and its derivatives were determined and compared with those of benzyl benzoate. based on the ld50 values of 1-hydroxynaphthalene derivatives against d. farinae, d. pteronyssinus, and t. put ... | 2013 | 23757178 |
| the relation of multiple sclerosis with allergy and atopy: a case control study. | multiple sclerosis (ms) and allergy are believed to up regulate t helper cell type 1 (th1) and t helper cell type 2 (th2) responses, respectively. it has been shown that disequilibrium in the ratio of th1/th2 activities may increase frequency of one disease and decrease the frequency of the other. the aim of this study was to investigate the relation of ms with allergy and atopy in new diagnosed ms patients. this case-control study was conducted on 40 new diagnosed ms patients and the same numb ... | 2013 | 23754358 |
| omalizumab attenuates airway inflammation and interleukin-5 production by mononuclear cells in patients with severe allergic asthma. | omalizumab, an anti-immunoglobulin e monoclonal antibody, has shown an inhibitory effect on airway inflammation, which may be associated with clinical improvement of severe asthma. this study evaluated changes in airway inflammation and cytokine release by the peripheral blood mononuclear cells (pbmcs) of japanese patients with severe asthma after administration of omalizumab. | 2013 | 23711861 |
| group v secretory phospholipase a2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation. | we reported that pla2g5-null mice lacking group v secretory phospholipase a2 (gv-spla2) showed reduced eosinophilic pulmonary inflammation and th2 cytokine generation when challenged with an extract from house dust mite dermatophagoides farinae, compared with wild-type (wt) controls. adoptive transfer studies suggested that gv-spla2 in dendritic cells was necessary for sensitization of pla2g5-null mice, but was not sufficient to induce the effector phase of pulmonary inflammation. in this study, ... | 2013 | 23650617 |
| proteins and endotoxin in house dust mite extracts modulate cytokine secretion and gene expression by dermal fibroblasts. | house dust mite extracts used for diagnostic tests and immunotherapy contain bioreactive molecules including proteins and endotoxin. these extracts can influence the cytokine secretion and adhesion molecule expression by cells in the skin and lung airways. the aim of this study was to determine the role of proteins and endotoxin in mite extracts in modulating gene expression and cytokine secretion by human dermal fibroblasts. cultured normal human dermal fibroblasts were stimulated with whole mi ... | 2013 | 23640713 |
| assessment of total/specific ige levels against 7 inhalant allergens in children aged 3 to 6 years in seoul, korea. | childhood allergies are a serious problem, as they may lead to lifetime chronic disease. determination of total and specific ige levels is known to be a diagnostic tool for allergic sensitization; however, ige levels are affected by various factors, such as age, sex, ethnicity, and geographic area. thus, we evaluated the distribution of total and specific serum ige levels against seven inhalant allergens in preschool children and examined their association with allergic diseases in seoul, korea. | 2013 | 23638315 |
| house dust mite allergen der f 2 induces interleukin-13 expression by activating the pi3k/akt pathway. | house dust mites (hdms) are a common cause of allergic asthma. the group 2 allergen from dermatophagoides farinae, der f 2, is one of the major hdm allergens. elevated der f 2 immunoglobulin e (ige) levels are observed in most of the allergic patients. interleukin-13 (il-13), a gene associated with asthma pathology, was induced by der f 2 in beas-2b human airway epithelial cells; however, the signaling pathways associated with der f 2 are not fully understood. in this study, we identified a role ... | 2013 | 23564227 |
| sublingual immunotherapy for experimental allergic conjunctivitis in a murine model induced by dermatophagoides farinae allergen. | sublingual immunotherapy (slit) is a clinically effective treatment in allergic conjunctivitis (ac); however, the mechanism of the underlying pharmacodynamics remains unclear. here, we investigate the efficacy and the mechanism of a sublingually administered dermatophagoides farinae (der f) vaccine in a murine ac model. | 2013 | 23548949 |
| involvement of nuclear factor of activated t cells in granulocyte-macrophage colony-stimulating factor production in canine keratinocytes stimulated with a cysteine protease. | a previous study demonstrated that the cysteine protease of dermatophagoides farinae induced production of granulocyte-macrophage colony-stimulating factor (gm-csf) in a canine epidermal keratinocyte progenitor cell line (cpek); however, the molecular mechanism has not been elucidated. | 2013 | 23530471 |
| inhibitory effects of polysaccharide-rich extract of phragmites rhizoma on atopic dermatitis-like skin lesions in nc/nga mice. | phragmites rhizoma was reported to have anti-oxidative and free radical scavenging activity. it also has been traditionally used to suppress inflammation. in the present study, we aimed to evaluate the topical effects of the polysaccharide-rich extract of p. rhizoma (pep) on atopic dermatitis. | 2013 | 23517777 |
| oleanolic acid acetate inhibits atopic dermatitis and allergic contact dermatitis in a murine model. | atopic dermatitis (ad) and allergic contact dermatitis (acd) are common allergic and inflammatory skin diseases caused by a combination of eczema, scratching, pruritus, and cutaneous sensitization with allergens. this paper examines whether oleanolic acid acetate (oaa) modulates ad and acd symptoms by using an existing ad model based on the repeated local exposure of mite extract (dermatophagoides farinae extract, dfe) and 2,4-dinitrochlorobenzene to the ears of balb/c mice. in addition, the pap ... | 2013 | 23499868 |
| investigation of the effect of probiotic exposure on filaggrin expression in an experimental model of canine atopic dermatitis. | atopic dermatitis (ad) results from complex interactions between an impaired skin barrier and immunological stimulation. filaggrin is a key protein for the skin barrier, and its expression is decreased in subsets of atopic dogs and can be modified by inflammation; thus, immunomodulatory approaches may alter its expression. probiotics have been explored for the prevention and treatment of allergies, owing to their immunomodulatory properties; however, it is currently unknown whether they can modu ... | 2013 | 23432387 |
| species diversity of house dust mites in beijing, china. | even though house dust mites are one of the most important allergens, there have been few studies in china for their identification and diversity. in this study, we reported that dermatophagoides siboney was found for the first time in beijing, china, in a temperate zone and it was also the first reported in asia. this survey of mite prevalence was carried out in several districts of beijing, a city of thirty million people. house dust samples were collected from 38 homes of mite-allergic patien ... | 2013 | 23427649 |
| the development of allergic rhinitis in children previously diagnosed as nonallergic rhinitis. | nonallergic rhinitis (nar) is characterized by nasal symptoms similar to allergic rhinitis (ar) without an ige-mediated immune response. limited data are available on the natural history of nar in its progression toward ar, particularly in children. this study evaluates the development of ar in children who were previously diagnosed with nar. | 2013 | 23406600 |
| serum eosinophil cationic protein level in chinese subjects with nonallergic and local allergic rhinitis and its relation to the severity of disease. | nonallergic rhinitis (nar) is a common disease, and local allergic rhinitis (lar) is a newly described entity that is called "entopy" in recent years. however, the etiology and incidence of nar and lar are uncertain. this study evaluates the incidence of lar in chinese subjects and serum eosinophil cationic protein (ecp) levels in patients with nar and lar and its relationship with symptom scores. | 2013 | 23406588 |
| house dust mite sublingual immunotherapy: a double-blind, placebo-controlled study in elderly patients with allergic rhinitis. | immunotherapy in elderly patients is controversial, and there is still no evidence supporting this treatment's safety and efficacy in this population. this study was performed to evaluate the safety and efficacy of specific sublingual immunotherapy for house dust mite (hdm) allergens in patients over 60 years of age with allergic rhinitis and a confirmed allergy to hdm. | 2013 | 23331565 |