Publications

[vaginal microflora in vaginitis in randomly selected group of women].		1979	394483
serodiagnosis of trichomonas vaginalis infection by the indirect fluorescent antibody test.	the indirect fluorescent antibody test was used to detect antibodies to trichomonas vaginalis in 200 antenatal patients. a total of 104 (52%) gave a positive reaction with antigen prepared from cultures of trichomonas isolated from seven of the patients. antitrichomonal antibody was detected at a 1/4 dilution in 90% of patients with proven trichomoniasis, while the highest dilution at which antibody was detected was 1/32. igg rather than igm appeared to be the antibody class involved. of those p ...	1979	395169
the changing pattern of sexually transmitted diseases in adolescents.	the factors associated with the rising incidence of sexually transmitted diseases in adolescents in england and wales are both social and medical. among the social factors is the large part played by sex in periodicals, advertisements, the theater, radio, and television. also playing their part are increased mobility of populations, particularly moves from rural to urban areas, increased affluence, increased alcohol comsumption and leisure time together with greater personal freedom. the medi ...	1979	582209
[reduced sensitivity of trichomonas vaginalis to metronidazole].		1979	425105
[behavior of the vaginal part of the guinea pig cervix uteri after infection with trichomonas vaginalis. (2. appearance of mast cells)].		1979	483812
g1549, a new cyclic hydroxamic acid antibiotic, isolated from culture broth of pseudomonas alcaligenes.	antibiotic g1549, isolated from culture broth of pseudomonas alcaligenes, is a new cyclic hydroxamic acid with a 1-hydroxy-2(1h)-pyridinone structure that complexes with metals. the structure of g1549 is suggested to be 1-hydroxy-5-methoxy-6-methyl-2(1h)-pyridinone. in vitro, g1549 and its copper and ferric complexes show moderate activity against gram-positive bacteria, fungi and trichomonas vaginalis. topical application of g1549 and its copper and ferric complexes protect guinea pigs against ...	1979	528379
effect of different contraception on microbial vaginal flora and immunoglobulin levels.	the effect of oral contraceptives (combined ocs) and iuds (lippes loop d) on vaginal flora and immunoglobulin levels (igg and iga) was studied via bacteriological examination of 3 vaginal swabs (cervical mucus) from each of 120 nonpregnant, multiparous randomly selected women aged 20-40 years. all participants had used the respective contraceptive method from 1-10 years. iga and igg levels increased simultaneously with duration of oc intake until 4 years and then decreased thereafter. both ig ...	1979	541598
[determination of secretory iga in vaginal lavage of 25 subjects with vaginitis caused by trichomonas vaginalis].		1979	550735
genetic control of trichomonas vaginalis infection. i. resistance or susceptibility among different mouse strains.	susceptibility of different strains of mice to infection with trichomonas vaginalis was determined. striking strain differences in susceptibility to t. vaginalis inoculum were observed in different mouse strains suggesting that susceptibility is under control of genes mapping mainly outside the major histocompatibility complex.	1979	552834
[a survey of trichomonas vaginalis infection of 1,125 married women (author's transl)].		1979	555722
[an experimental study on the pathogenicity of korean strains of trichomonas vaginalis]	in order to evaluate the pathogenicity of korean strains of trichomonas vaginalis, an experimental inoculation of t. vaginalis into mouse peritoneal cavity was performed. fifteen strains of t. vaginalis were selected from 53 infected cases and were cultured axenically in roiron-rattner medium at 37 degrees c for 48 hours. each strain, at the dose of 0.5 ml of 1 x 10(6)/ml trichomonads, was inoculated intraperitoneally to a group of 10 mice, respectively. a total of 15 groups, consisted of 150 mi ...	1979	12902756
prevalence of trichomonas vaginalis in korean military personnel.	a study of trichomonas vaginalis in korean military personnel, based on the discovery of motile trophozoites by prostate culture and urine wet smear methods, has been carried out during the period from may, 1975 to october, 1977. in the army general hospital clinics, specimens of prostatec secretion and urine were provided by the in- and out-patients without any noticeable genito-urinary symptoms. in a total of 977 specimens 33 cases were revealed positive for trichomonas vaginalis. of these, 23 ...	1980	12902736
vaginal discharge in the black pregnant patient: an evaluation of the relationship between symptomatology and diagnosis.	three hundred and thirty pregnant black antenatal patients with symptomatic vaginal discharge were assessed. there appeared to be no correlation between the symptoms (pruritus, burning, amount of discharge and appearance) and the expected diagnosis. the common organisms trichomonas vaginalis, haemophilus vaginalis, candida albicans and neisseria gonorrhoeae were evaluated. it was also noted that a large number of patients (54%) had negative cultures although their complaints were similar to thos ...	1980	6773152
[occurrence of bactericidal substance in the cells of trichomonas vaginalis].		1980	6775416
[study of a drug combination with contraceptive, antibacterial, antimycotic and prophylactic action, for topical use in venereal diseases. 4. effect of the combination of oxyquinoline sulfate, copper sulfate and lactic acid on trichomonas vaginalis and on candida albicans in vivo].		1980	6777111
genital chlamydia trachomatis infection in women.	specimens for isolation of neisseria gonorrhoeae, chlamydia trachomatis, candida albicans, and trichomonas vaginalis were collected from 585 women attending clinics for venereal diseases. the isolation rates in women attending clinics for venereal diseases. the isolation rates in women with and without genitourinary symptoms, the course of untreated chlamydial infection, the occurrence of chlamydial urethritis, and the response to antibiotic treatment were investigated. a 30% incidence of chlamy ...	1980	6777719
effect of listeria monocytogenes lipids on the immunity of mice against candida albicans, cryptococcus neoformans and trichomonas vaginalis.	the effect of listeria monocytogenes lipids (lm lipids) on immunity against candida albicans, cryptococcus neoformans and trichomonas vaginalis was studied in mice. the administration of lm lipids did not affect significantly the course of t. vaginalis infection. on the other hand, single lm lipids injection markedly decreased the mortality rate of mice with mycotic infections, and significantly accelerated the elimination of fungal cells from liver, spleen and blood circulation of animals. it i ...	1980	6778451
lectin analysis of surface saccharides in two trichomonas vaginalis strains differing in pathogenicity.		1980	6971328
an immunofluorescence test to detect serum antibodies to giardia lamblia.	we used an indirect immunofluorescence test with giardia lamblia trophozoites as antigen to detect anti-g. lamblia antibodies in serum. seventy-one patients and control subjects were studied in a blinded protocol. titers in 29 of 30 patients with symptomatic giardiasis (1:16 to 1:1024) did not overlap titers in 19 healthy control subjects (1:2 to 1:4); titers in 15 patients with hookworm, entamoeba histolytica, or intestinal bacterial overgrowth were 1:16 or less absorption of giardiasis patient ...	1980	6255845
sexually transmitted diseases in clinic patients in lagos.	in a study of patients attending an std referral clinic in lagos, nigeria, the age distribution was similar to that seen on other parts of the world and the male-to-female ratio was 1.3:1. non-specific genital infection was diagnosed in about 59% of patients and gonorrhoea in 19%. most strains of neisseria gonorrhoeae were sensitive to penicillin (1 unit) and the six relatively penicillin-resistant strains did not produce penicillinase. candidosis and trichomoniasis were each diagnosed in about ...	1980	6892789
natural cell-mediated cytotoxicity against trichomonas vaginalis in the mouse. i. tissue, strain, age distribution, and some characteristics of the effector cells.		1980	6965381
trichomonas vaginalis: reevaluation of its clinical presentation and laboratory diagnosis.	vaginal discharge is the most common complaint and trichomonas vaginalis vaginitis the most frequently diagnosed problem among women attending the dekalb county georgia, veneral disease clinic. despite this prevalence, the 1837 observations of donné are the criteria frequently used in the clinical and laboratory diagnosis of trichomoniasis. our study shows that a purulent, frothy discharge is indeed a characteristic of trichomonal vaginitis, but if it is used as the sole diagnostic criterion, 88 ...	1980	6965976
urine culture for the detection of trichomonas vaginalis in men.	urine samples were collected from 248 men, 21 of whom were known contacts of women infected with trichomonas vaginalis. this organism was cultured from only three of the 21 specimens from patients in the contact group. the cultural technique was shown to be capable of reliably detecting small numbers of organisms under practical conditions; it appears, therefore, that most male contacts shed relatively few trichomonads and that the infective dose for women must be correspondingly small.	1980	6966175
[new dry nutrient medium made of nonfood stock for culturing vaginal trichomonads].		1980	6967245
[removal of accompanying yeast fungi from cultures of trichomonad strains (polymastigina)].	for purifying the cultures of trichomonas vaginalis and t. hominis from associating yeasts we inoculated them into the upper layer of a viscous medium containing 0.1% agar (teras, 1955; tompel, teras, 1976) poured into a burette. on the 2nd or 3rd day after inoculating the first drops obtained from the lower end of the burette contained as a rule only trichomonads. for purifying the cultures of t. tenax from associating yeasts we prepared a special semisolid medium from the liquid egg medium (wa ...	1980	6967578
[effect of orotic acid, hypoxanthine and arginine hydrochloride on the development of a vaginal trichomonad culture].		1980	6967658
trichomoniasis. new ideas on an old disease.	trichomoniasis is probably the most widespread sexually transmitted disease of man. the causative organism, trichomonas vaginalis, can normally be found on microscopic examination of vaginal exudate, although serological diagnostic techniques have recently been described. the organism has now been recognized as a pathogen, and, although infection has been associated with cervical cancer, a causative link has not been established. despite both humoral and cellular immune responses, protective imm ...	1980	6969449
measuring the in vitro susceptibility of trichomonas vaginalis to metronidazole: a disk broth method.	strains of trichomonas vaginalis were evaluated for their in vitro responses to metronidazole. a serial twofold dilution method that measured minimal inhibitory concentrations (mics) by cessation of trophozoite motility was compared with the disk broth method, in which both cessation of motility and inhibition of trophozoite proliferation were used for measurement of mics. these methods gave comparable results in distinguishing a metronidazole-resistant and two metronidazole-susceptible strains ...	1980	6969450
trichomonas vaginalis associated with nongonococcal urethritis and prostatitis.	trichomonas vaginalis was recovered from three (1.7%) of 179 men with nongonococcal urethritis. prostatitis was found in 11 (8%) of 138 of these men who had prostatic examinations; t. vaginalis was recovered from two of the 11. serologic evidence (an indirect hemagglutination titer of greater than or equal to 1:80) was found in 20 (14%) of 146 men; four of the 20 had prostatitis and two of these had prostatitis associated with t. vaginalis. in a group of 26 men with urethritis and prostatitis as ...	1980	6969451
[a systematic search for ureaplasma urealyticum in vaginal swabs. the results (author's transl)].	6.6 per cent 1.069 vaginal swabs showed ureaplasma urealyticum in our patients. ureaplasma does not seem to alter the cytology or the physiological flora of the vagina. on the other hand trichomonas vaginalis was often found in association with it. there is no racial predisposition to infection of the vagina with ureaplasma. pregnancy, however, does seem to favour the growth of this mycoplasma. but this does not seem to have any adverse effect on the progress of the pregnancy.	1980	6969736
immunocytochemical identification of trichomonads.	trichomonas vaginalis is one of the more common pathogens of the genitourinary tract. morphologic studies of trichomonal infections, however, have been hampered by the fragile nature of these thin-walled flagellates and the lack of specific histochemical procedures to identify the fragmented organisms found in tissue sections. these limitations have usually restricted positive identification to smears of freshly obtained specimens. in an attempt to overcome these limitations, a rabbit antiserum ...	1980	6989339
update: adolescent gynecology.	as adolescents develop their sexual identities they are at risk for acquiring sexually transmitted diseases, unwanted pregnancies, and cervical dysplasia. as physical growth and development progress during adolescence, the risk of developing dysmenoorhea or adverse effects from exposure to diethylstilbestrol increase. the pediatrician with a background in growth and development should be capable of recognizing these conditions and participating in their management.	1980	6990360
metronidazole inactivation by aerobes.		1980	6995421
[evaluation of the usefulness of indirect immunofluorescence technic for serodiagnosis of trichomonas vaginitis].		1980	6996038
[differential diagnosis of "sterile leukocyturia"].		1980	7002525
three metronidazole-resistant strains of trichomonas vaginalis from the united states.	trichomonas vaginalis isolates were obtained in the united states from three women with trichomoniasis refractory to routine treatment with metronidazole. cure was obtained in these cases with increased dosage of metronidazole. in experimental mouse infections, all three strains showed a significantly (about 10 to 20 times) lower susceptibility to metronidazole than did a number of control strains. in vitro, the lowered susceptibility could be detected only in an aerobic assay but not in the rou ...	1980	7004190
the clinical and laboratory diagnosis of trichomonas vaginalis infection.	one hundred consecutive female patients attending an inner-city clinic for treatment of sexually transmitted diseases were evaluated for the presence of trichomonas vaginalis by history, physical examination, 0.85% nacl wet mount, papanicolaou smear, and culture. of the 100 women, 54 were found to be harboring the parasite, as determined by one or more positive diagnostic tests. this prevalence corresponds with that reported previously. the information gained from the history (symptoms and phase ...	1980	7006116
inhibition of trichomonas vaginalis by fungi during associative growth.	in controlled studies of associative growth, candida albicans and torulopsis glabrata, but not candida parapsilosis, inhibited the proliferation and eventually the viability of trichomonas vaginalis. the inhibition patterns produced against the trichomonad by c. albicans or t. glabrata were observed with trichomonad-fungus inoculum ratios ranging from 230:1 to 1:100. the onset of inhibition of t. vaginalis by t. glabrata was immediate, whereas that of c. albicans began after incubation for 48 hr ...	1980	7006117
in vitro attraction of polymorphonuclear leucocytes by trichomonas vaginalis.	boyden chambers were used to investigate the attraction of polymorphonuclear leucocytes to t. vaginalis. chemotaxis to live organisms was demonstrated, and chemotaxis to t. vaginalis supernatant was shown to be concentration dependent. both chemokinesis and true chemotaxis characterized the response to supernatants. there was no chemotaxis to the supernatant after it had been heated to 60 c for 1 hr, or to the supernatant from formalin-fixed t. vaginalis. the chemotactic factor in the supernatan ...	1980	7012294
[occurrence of trichomoniasis in women with intra-uterine devices (author's transl)].	the authors investigated the biocenosis in the vaginas of 216 women with iud and 124 controls without any contraceptive. the incidence of vaginal trichomoniasis in iud probands was higher with significance than that among the controls. culture testing is indispensable to rule out the presence of vaginal trichomoniasis. parasites were not readily detectable from stained and native specimens unless infections were massive. the cytological findings recorded from the above probands were within the n ...	1980	6970467
[cytomorphological changes and intensity of inflammation in cervico-vaginal smears containing trichomonas vaginalis, candida albicans, and leptothrix vaginalis].		1980	7412371
diagnosis and treatment of vaginal discharge in pregnancy.	a total of 232 pregnant black antenatal patients was examined to determine the clinical features of vaginal infection. there was no correlation between the symptoms and the infection. the finding of a 'strawberry' vagina was specific for trichomonas vaginalis infection, for which a single dose of 1 600 mg metronidazole (flagyl) was found to be a highly effective form of therapy.	1980	7423322
trichomonacidal activity of human polymorphonuclear neutrophils: killing by disruption and fragmentation.	polymorphonuclear neutrophils (pmns) were shown to kill trichomonas vaginalis in vitro; 10(2)-10(3) trichomonads were incubated with 3 x 10(6) pmns on tissue culture plates, and surviving organisms were enumerated in pour plates. after 60 min of aerobic incubation at 37 c, 100% (+/- 0) of the trichomonads had been killed, and nitroblue tetrazolium was reduced at the interface between the pmns and trichomonads. the importance of oxidative microbicidal systems was confirmed by the observations tha ...	1980	7441017
isolation of trichomonas vaginalis resistant to metronidazole.		1980	6106121
susceptibility of abortion patients to infection: correlation to cervical flora.	cervical bacterial microflora was studied with a semiquantitative method in 29 women both before and after the termination of their pregnancy. the main findings were high prevalence of anaerobic bacteria (in 72%-79% of the specimens) consisting predominantly of bacteroides species and anaerobic gram-positive cocci, and low prevalence of aerobic bacteria (in 24%-38% of the specimens). among the other microbes studied, the prevalence of chlamydia excretors was high (24%), probably reflecting a pro ...	1980	6106600
gonorrhea, trichomonas and candida among gravid and nongravid women in cameroon.	a case-control study of 1358 pregnant and nonpregnant women with and without symptoms of a lower genital tract infection were investigated for evidence of venereal disease. the prevalence of gonorrhea, trichomonas and candida in pregnancy was 15.0%, 20.6% and 41.3%, respectively, while the equivalent percentages in the nonpregnant women varied from 16.5% to 21.6%, 2.4% to 22.8% and 33.3% to 39.3%. however, these differences are not statistically significant. the implications of the findings are ...	1980	6106601
a comparison of five methods for the detection of trichomonas vaginalis in clinical specimens.		1980	6155588
immunoperoxidase staining of trichomonas vaginalis in cytologic material.	in the course of studies on the histopathology and pathogenesis of trichomonal infections, specific antisera to trichomonas vaginalis were produced. using these antisera, conventional immunocytochemical techniques were modified and applied to a variety of cytologic specimens. with this methodology, trichomonal organisms were identified in specimens from usual and unexpected locations. these findings plus the potential applications of similar methodologies to other areas of cytopathology are repo ...	1980	6159760
evaluation of acridine orange stain for detection of trichomonas vaginalis in vaginal specimens.	vaginal exudates from 105 patients were examined by direct wet-mount microscopy and acridine orange stain for the presence of trichomonas vaginalis. both procedures demonstrated greater than 90% agreement in both sensitivity and specificity. when specimens can be examined immediately after collection, it appears that wet-mount microscopy is almost as sensitive as acridine orange staining for detection of t. vaginalis.	1981	6174543
the enzymes of pyrimidine biosynthesis in a range of parasitic protozoa and helminths.	the activities of carbamoylphosphate synthase, aspartate transcarbamoylase, dihydroorotase, orotate phosphoribosyl transferase and orotidine-5'-phosphate decarboxylase, five of the six enzymes of pyrimidine biosynthesis, have been measured in crithidia fasciculata, trypanosoma cruzi, leishmania major, trichomonas vaginalis, eimeria tenella, toxoplasma gondii, plasmodium berghei, fasciola gigantica, schistosoma mansoni, hymenolepis diminuta, nippostrongylus brasiliensis and trichuris muris. the m ...	1981	6111750
isolation of trichomonas vaginalis resistant to metronidazole.		1981	6116037
metronidazole-resistant trichomonas vaginalis.		1981	6118546
[7th pan-polish antitrichomonas symposium. lodz, 27-28 june 1980].		1981	6120598
new chemotherapeutic nitroheterocycles active against 5-nitroimidazole-resistant strains of trichomonads.	the synthesis and the trichomonacidal activity of some 4-substituted 2-imidazolylquinazoline derivatives are described. the new compounds were highly active against metronidazole-sensitive and metronidazole-resistant strains of trichomonads. this was demonstrated in vitro as well as in various trichomoniasis models in mice and rats after oral treatment.	1981	6971111
behaviour and pathogenicity of trichomonas vaginalis in epithelial cell cultures: a study by light and scanning electron microscopy.	the behaviour and pathogenic effects of trichomonas vaginalis in mammalian cell cultures were studied using light microscopy and scanning electron microscopy. six hours after inoculation of the parasites into the cell cultures about 10% of the epithelial monolayer was destroyed. the parasites adhered to the epithelial cells, developed an amoeboid morphology, and crawled over and under the monolayer of cells. these observations suggest that the adhesiveness, amoeboid morphology, and motility of t ...	1981	6971140
a comparison of four media for the cultivation of trichomonas vaginalis.		1981	6971152
the incidence of selected vaginal infections among pregnant urban blacks.	a total of 232 black antenatal patients was assessed in a cross-sectional study and a total of 80 in a longitudinal study. trichomonas vaginalis infection occurred almost twice as frequently as candida albicans infection. neisseria gonorrhoeae infection was present in 10% of patients, and mixed infections were present in 34% of patients.	1981	7233301
oral contraceptive use and prevalence of infection with chlamydia trachomatis in women.	one thousand eight non-pregnant women aged 16-34 years, presenting for the first time at a clinic for sexually transmitted diseases (std), were examined and screened for infection with chlamydia trachomatis, neisseria gonorrhoeae, trichomonas vaginalis, and candida species. the respective prevalence rates were 21.1%, 20.7%, 13.4%, and 27.8%. isolation rates for c trachomatis, either occurring alone or in association with other genital infections, were significantly greater in women using oral co ...	1981	7237082
intestinal and urogenital flagellates.	although the human alimentary and urogenital tracts are parasitized by seven species of flagellate protozoa [115], only two, giardia lamblia and trichomonas vaginalis, are generally considered to be pathogens. this review, therefore, concentrates on these organisms and in particular on the experimental and clinical chemotherapy of trichomoniasis and giardiasis. due to the limited space and the availability of excellent recently published reviews, topics such as life cycles, epidemiology, prevale ...	1981	7259131
some reactions of 1,4-dihydropyridines with organic azides. synthesis of 2,7-diazabicyclo[4.1.0]hept-3-enes with analgesic and antiprotozoal activity.	the 1,3-dipolar cycloaddition reaction of 1,4-dihydropyridines, 2, with organic azides, 3, afford 2,7-diazabicyclo[4.1.0]hept-3-enes, 4, which exhibit significant analgesic and antiprotozoal activities. the most active analgesics, 4a and 4c, were more potent than aspirin or dextropropoxyphene. diazabicyclo[4.1.0]hept-3-enes 4a-e exert potent antiprotozoal activity, inhibiting growth of trichomonas vaginalis at concentrations of less than 10 micrograms/ml of medium. the broad spectrum pharmacolog ...	1981	7265132
nitroimidazoles in the canine prostate, vagina, and urethra.	diffusion of metronidazole and tinidazole in canine prostatic secretion was studied and compared to the diffusion of metronidazole into the canine vagina. this particular comparison was made because prostatic secretion represents an acidic environment in contrast to the canine vagina which has a basic ph. metronidazole reached significantly higher concentrations in the prostatic secretion (ps) than in plasma (p). no differences were found in the concentrations of tinidazole in p and ps. plasma a ...	1981	7279813
[diffusion of trichomonas vaginalis and of several species of candida in a sample of the female population of bologna as related to the principal endogenous and exogenous factors].	in this work, the authors report the results of an epidemiological study on trichomonas vaginalis and candida spp. frequency in a sample of the adult female population in bologna. they also studied the influence exerted by some epidemiological variables such as age, profession, civil status, educational status, use of specific products for feminine hygiene, contraceptive usage, and sexual habits. some interesting correlations were observed. (author's modified)	1981	7346774
igg antibody to giardia lamblia detected by enzyme-linked immunosorbent assay.	a sensitive, reproducible enzyme-linked immunosorbent assay using unfixed, intact giardia lamblia trophozoites as antigen is described. employing this assay, we demonstrated that 81% of 59 symptomatic giardiasis patients and 12% of 17 uninfected control subjects had circulating igg antibodies to g. lamblia. eleven out of 15 patients tested serially had detectable antibody from 2 wk to 15 mo after therapy for acute infection. the prevalence of antibody in 197 unselected individuals in the washing ...	1981	7014351
urologic aspects of trichomoniasis.		1981	7014514
a preliminary study of antibodies against trichomonas vaginalis infection using the i.f.a.t.		1981	7028881
vaginitis associated with vaginal malodour.	in two general practices in perth, western australia, the most common microbiological causes of vaginal discomfort in 368 patients were candida albicans. gardnerella (haemophilus) vaginalis, trichomonas vaginalis and bacteroides fragilis. amongst patients with abnormal vaginal odour, with or without vaginitis, the most common cause of odour was g. vaginalis. the writers advocate that heavy growths of group b streptococci, escherichia coli, and enterococci should be considered to be the possible ...	1981	7029228
[indirect immunofluorescence technic in the serodiagnosis of trichomonas infections].		1981	7036229
[evaluation of the methods used in microbiological diagnosis of mycoses and trichomonas infections of the genital tract].		1981	7039140
culture of seminal fluid in a fertility clinic.	to determine whether the culture of seminal fluid in a fertility clinic is of importance, bacterial cultures were obtained in a consecutive series of 96 patients. routine bacteriologic cultures were performed within 1 hour of collection. ureaplasma urealyticum (t-mycoplasma) cultures were also obtained in the last 31 of the patients in this series. of these 96 patients, 11% showed significant bacterial growth (greater than 10(4) colonies/ml) in the semen specimens, 8% in those patients with norm ...	1981	7009221
metronidazole.		1981	6970332
metronidazole metabolism in cultures of entamoeba histolytica and trichomonas vaginalis.	acetamide forms from metronidazole in cultures of either entamoeba histolytica or trichomonas vaginalis as it does in cultures of bacteria which are susceptible to this drug. under aerobic conditions, the formation of acetamide is more rapid in a strain of t. vaginalis which is more susceptible to metronidazole. thus, it appears that the formation of acetamide may be associated with the microbiocidal action of metronidazole.	1981	6272633
[use of a contraceptive suppository as chemoprophylaxis against sexually-transmitted diseases].	the incidence of sexually transmitted diseases (std), especially gonorrhea, has risen dramatically in the past 2 decades. the population at greatest risk is also at high risk for unwanted pregnancies. since currently employed treatment methods are failing to curb the problem, a search was instituted for an available vaginal contraceptive that would have a prophylactic effect against these diseases. in vitro studies have indicated that a vaginal contraceptive made of phenylmercuric acetate is ...	1981	6277015
sexually transmitted infections and cervical atypia.	epidemiologic studies have long associated cervical cancer and dysplasia with sexual activity. in the past two decades an abundance of biological and epidemiologic data have indicated a relationship between herpes simplex virus type 2 (hsv-2) and these conditions. unfortunately, the strength of the evidence (albeit circumstantial) has led many researchers to focus exclusively on the putative role of hsv-2 as the carcinogen. at the same time, many studies have shown that cervical atypia, if it is ...	1981	6277023
cytotoxicity of human peripheral blood monocytes against trichomonas vaginalis.	human peripheral blood monocytes were purified by adherence on microexudate-coated plastic and detached by exposure to 1 mm ethylenediamine tetracetic acid. lysis of trichomonas vaginalis was measured as release of 3h-thymidine from prelabelled protozoa after 48 hr of incubation. human blood monocytes had appreciable levels of spontaneous cytotoxicity against trichomonas vaginalis at effector-to-target cell ratios ranging from 3:1 to 25:1. cytotoxicity was expressed with fetal bovine serum and h ...	1981	6279344
[in vitro studies on the identification of metronidazole resistant strains of trichomonas vaginalis (author's transl)].	in order to ascertain the minimal lethal concentration (mlc) of metronidazole for strains of t. vaginalis with varying susceptibility, comparative studies were carried out under different assay conditions. these studies were made under aerobic or anaerobic conditions in microtiter plates and culture tubes respectively, using the following media: cach with/without agar, cplm, trichomonas medium (merck), fluid thioglycollate (bbl), tym with/without agar and sts modified. thus only mlc values great ...	1981	6971538
ankylosing spondylitis associated with trichomonas vaginalis infection.	a patient is described who developed signs and symptoms of ankylosing spondylitis after prostatitis due to trichomonas vaginalis. chronic prostatitis of unknown cause had previously been reported as being common in patients with ankylosing spondylitis. the observations in this case raise the possibility that t. vaginalis might play a role in the prostatitis and pathogenesis of ankylosing spondylitis in some patients.	1981	6972386
the sensitivity of trichomonas vaginalis and trichomonas gallinae to ultraviolet radiation.		1981	6973159
[the flagellate trichomonas vaginalis and its bacterial environment in vaginal medium].		1981	6973309
new defined and semi-defined media for cultivation of the flagellate trichomonas vaginalis.	studies on the nutrition and physiology of trichomonas vaginalis have been hampered by the lack of a defined synthetic medium in which to grow the organism. new synthetic media free of ill-defined supplements and serum which support good growth of t. vaginalis have been developed in this study. the first successful approach to a defined medium resulted from the modification of the tissue-culture medium cmrl 1066. essential modifications included (1) lowering the redox potential of the medium by ...	1981	6973740
mechanisms of selective toxicity of metronidazole and other nitroimidazole drugs.		1981	6974031
preliminary observations on human vaginal and intestinal trichomonads.		1981	6975335
in vitro susceptibility of trichomonas vaginalis to zinc.	the prostate has long been considered to be a site of sequestration of trichomonas vaginalis. from this reservoir, organisms are thought to be shed during intercourse and produce repeated infections in the female genitourinary tract. bacteria known to cause prostatitis are inhibited by concentrations of zinc found in uninfected prostatic secretions. the present study demonstrates a similar inhibitory effect of zinc on the growth of t. vaginalis. this finding would suggest that, in otherwise heal ...	1981	6975472
relationship between size of trichomonas vaginalis and pathogenicity.		1981	6975756
[biological characteristics of trichomonas vaginalis].		1981	6976202
trichomonas vaginalis: dependence of resistance among different mouse strains upon the non-h-2 gene haplotype, sex, and age of recipient hosts.		1981	6976269
[urethro-prostatitis caused by trichomonas vaginalis].		1981	6977175
trichomonas vaginalis infection of the median raphe of the penis.	a case of trichomonas vaginalis infection involving the median raphe of the penis is presented. the infection was contracted after sexual exposure. the patient had no urethral discharge but had a penile swelling tht discharged pus. microscopic examination and culture of the discharge showed the presence of t. vaginalis. treatment with metronidazole (250 mg thrice daly for seven days) eradicated the infection, but the swelling remained and a cyst was excised. one month after the surgical procedur ...	1981	6977195
sexually transmitted conditions among women college students.	we studied 500 unselected young women who consulted a gynecologist in a student health service. most participants were symptom-free and had normal physical examinations. few sexually transmitted infections were encountered. neisseria gonorrhoeae was recovered from two and trichomonas vaginalis was obtained from 14 of 500 women. chlamydia trachomatis was recovered from 20 (4.6%) of 439 participants. genital warts, genital herpes, and molluscum contagiosum, respectively, were noted in seven, four, ...	1981	6779634
urethritis in women attending an std clinic.	of an unselected group of 159 women attending a sexually transmitted diseases (std) clinic 20% (32) had symptoms of urethritis. a positive correlation existed between the finding of more than 10 polymorphonuclear leucocytes (pmnl) per high-power field in the gram-stained urethral smear and the presence of neisseria gonorrhoeae, chlamydia trachomatis, and trichomonas vaginalis. conversely, these organisms were rarely isolated if no pmnl were present. fewer cultures gave positive results for these ...	1981	6781707
[difficulties in obtaining a reliable test for determining the virulence of a parasitic flagellate (trichomonas vaginalis)].	base on intraperitoneal or subcutaneous inoculations, the tests of pathogenicity of t. vaginalis, for mice, do not seem reliable, in our experiments. the impossibility of obtaining reproducible results is bound to the heterogeneity of reactions to parasite of mice from the same strain. this individual effect demands a serious statistical study in the appreciation of pathogenicity.	1981	6786787
activation of the alternative complement pathway by trichomonas vaginalis.	the mechanism underlying the lysis of trichomonas vaginalis by normal human or guinea pig serum was investigated. the involvement of the complement system was demonstrated by the failure of human serum deficient in c3 or c8 to mediate parasite killing and by the ablation of lytic activity observed when fresh sera were heated at 56 degrees c or treated with ethylenediaminetetraacetate. fixation of human c3 on the parasite surface was demonstrated by indirect immunofluorescence. the involvement of ...	1981	6795124
[nutrient media for isolating gonococci and trichomonas vaginalis].		1981	6800146
[survival of bacteria phagocytized by trichomonas vaginalis].		1981	6801869
studies on the etiological role of tr. vaginalis in chronic prostatitis, and efficiency of the diagnostic methods employed.		1981	6804324
metronidazole: in vitro activity, pharmacology and efficacy in anaerobic bacterial infections.	metronidazole is a 5-nitroimidazole that has selective activity against anaerobic microorganisms, including bacteria and protozoa. intravenous metronidazole has recently been approved by the u.s. food and drug administration for the treatment of serious anaerobic bacterial infections. it is usually bactericidal at low concentrations, and its spectrum of activity encompasses almost all anaerobic bacteria and some capnophilic organisms. anaerobic bacteria known to be resistant to metronidazole inc ...	1981	6927601
action of clinically utilized 5-nitroimidazoles on microorganisms.	various nitroimidazoles are used as antimicrobial and radiosensitizing agents in human medicine. of these, 5-nitroimidazoles show high selective toxicity for anaerobic prokaryotes and eukaryotes. this review discusses the effects of 5-nitroimidazoles on microorganisms, i.e. microbicidal action, radiosensitizing action, inhibition of photosynthetic microorganisms, and induction of mutations. all these actions are enhanced by anaerobiosis and inhibited by aerobiosis or by the presence of certain r ...	1981	6941454
diagnosis of candidal colpitis using a semiliquid culture medium.	semiliquid culture medium is commonly used in the diagnosis of vaginal candida albicans and trichomonas vaginalis infection. in the present study growth of candida albicans in a medium inoculated with vaginal smear specimens and experimental cultures was evaluated. as a laboratory experiment, ph, po2, and pco2 were determined in different regions of the cultures. in the clinical part of the study agreement of clinical findings and candida albicans cultures was evaluated in the diagnosis of candi ...	1982	6818889
[serologic studies with solco trichovac, a vaccine against trichomonas vaginalis infections in women].		1982	6819981
[assay of iga specific anti-trichomonas vaginalis in vaginal secretions by indirect immunofluorescence].	30 vaginal secreta of women affected by acute and chronic trichomoniasis from the gynaecological hospital s. anna of turin were examined. in the same secreta the specific iga anti trichomonas vaginalis were detected using indirect immunofluorescence and titered on lc-partigen iga immunodiffusion plates. only in 30% of these cases a correlation between immunodiffusion and fluorescence test resulted.	1982	6821247
immune response to trichomonas vaginalis. i. genetic regulation of ige antibody response to t. vaginalis in mice.	the antigenicity of trichomonas vaginalis to elicit ige antibody was examined in mice. the soluble antigen was prepared by sonication of in vitro cultured t. vaginalis lines. balb/c mice were immunized by various doses of the antigen with alum followed by a booster injection on day 14 after primary injection of the protozoan antigen. the highest ige antibody titer was found in mice immunized with 30 micrograms of the antigen. the ige antibody response to trichomonas antigen is regulated by at le ...	1982	6802768