Publications

tuberculin hypersensitivity hepatitis in mice infected with mycobacterium bovis (bcg).	a systemic bcg infection in mice induced multiple small granulomas located mainly in the periportal areas of the liver. following systemic challenge of such mice with purified protein derivative of tuberculin (ppd), a rapidly developing hepatitis with diffuse intralobular mononuclear cell infiltration was precipitated, accompanied by high levels of aspartate transaminase in peripheral blood, hypoglycemia, focal hepatocyte necrosis, and accumulation of fibrinogen in liver. bacterial lipopolysacch ...	1981	7027805
failure of specific active immunotherapy in lung cancer.	a randomized trial comparing routine follow-up with a treatment regimen aimed at increasing specific anti-tumour immunity has been carried out in 95 patients after total surgical excision of lung cancer (not small-cell). treatment consisted of inoculation with an autologous irradiated suspension of tumour cells combined with a small dose of c. parvum given intradermally during convalescence. although treatment was associated with virtually no side effects, there has been no apparent benefit and ...	1981	7028069
immunotherapy for gynecologic malignancies.		1981	7031696
surgical adjuvant therapy for malignant melanoma.		1981	7031933
proteolytic enzymes released by liver macrophages may promote hepatic injury in a rat model of hepatic damage.	using macrophages isolated from the livers of normal rats and from rats injected intravenously with corynebacterium parvum 6 days previously, n-acetyl-glucosaminidase (nag) and plasminogen activator (pa) production have been measured during in vitro culture. there was a significant increase (p less than 0.02) in the supernatant activity of nag by the c. parvum recruited macrophages 8.05 +/- 1.17 nmol product/mg protein/h as compared with normal, 3.86 +/- 0.77 nmol product/mg protein/h. there was ...	1981	7009306
[passive transfer of "corynebacterium parvum" anti-tumour protection by stimulated peritoneal cells ].	a partial anti-tumour protection can be induced by transfer of peritoneal cells from mice pretreated with corynebacterium parvum, in the two experimental tumours studied: a mammary carcinoma syngeneic to c3h mice and a lymphosarcoma syngeneic to xvii mice. this protection is abolished by heating the peritoneal cells at 70 degrees c for 30 min, by a 2,200-rad irradiation or by a non-lethal irradiation of the recipient mice. transfer of normal peritoneal cells did not produce any anti-tumour prote ...	1981	6896973
bcg, corynebacterium parvum or mycobacterium leprae added to cultures of bcg-primed mouse spleen cells cause an enhanced primary antibody response in vitro.	a few weeks after mice were injected i.v. with 10(8) live mycobacterium bovis, bcg, the antibody response of their spleen cells to srbc in vitro was comparable with the response of cells from untreated mice. addition of bcg organisms to the culture vessels resulted in enhanced antibody-forming cell (afc) responses by the primed cells but not by the cells from the untreated mice. no evidence was found for a direct stimulation of b cells and cell depletion experiments suggested macrophages were di ...	1981	7007221
aerobic and anaerobic bacteria in deep infections after total hip arthroplasty: differential diagnosis between infectious and non-infectious loosening.	five separate biopsy samples for bacterial culture were taken at primary total hip arthroplasty in patients without signs of infection and at reoperation of patients with infectious and noninfectious loosening of the prosthesis. based on the results of the culture, on serologic results and on the erythrocyte sedimentation rate, bacteria of clinical significance could be distinguished from contaminants. growth in one or two of five biopsy samples was a strong indicator of contamination, while gro ...	1981	7009009
mechanisms of anti-tumor action of corynebacterium parvum. i. potentiated tumor-specific immunity and its therapeutic limitations.	the anti-tumor mechanism in mice induced by a subcutaneous injection of syngeneic tumor cells admixed with corynebacterium parvum was investigated. when mice were implanted in a hind footpad with x 2 1096) tumor cells admixed with 100 microgram c. parvum, the tumor that emerged grew progressively for about 9 d and then underwent progressive and complete regression. it was found that this c. parvum-induced regression was associated with the acquisition of a systemic, t cell-mediated mechanism of ...	1981	6974214
mechanisms of anti-tumor action of corynebacterium parvum. ii. potentiated cytolytic t cell response and its tumor-induced suppression.	it was shown that subcutaneous implantation of p815 tumor cells admixed with corynebacterium parvum resulted in the emergence of a tumor that grew for 9-10 d and then regressed. the onset of tumor aggression was preceded by the substantial generation in the draining lymph node and spleen of t cells capable of specifically lysing p815 target cells in vitro. the finding that the magnitude of this cytolytic response was much greater than the cytolytic response to a control tumor that grew progressi ...	1981	6974215
combined chemotherapy--radiotherapy on spleen hypertrophy after c. parvum: combined treatment with 5-fu cyclophosphamide and radiation.	c. parvum (cp) acts as a powerful stimulant for cell proliferation in the normal spleen. cp, in combination with radiation or cytotoxic chemotherapeutic agents, interfered with their effect to a lesser or greater degree depending upon the sequence in which cp and the cytotoxic therapy was applied. in these experiments, cyclophosphamide (cy), 5-fu and radiation were studied singly or in combination during the resting or after cp-stimulation, and the effects of the different combinations of chemot ...	1981	6975256
effect of immunotherapy with corynebacterium parvum and methanol extraction residue of bcg administered intravenously on host defense function in cancer patients.	the effects of active nonspecific immunotherapy were studied in 42 patients receiving daily iv corynebacterium parvum at 2 mg/m2 in 14-day courses and in 14 patients receiving iv methanol extraction residue of bcg (mer) at 0.5 mg/m2 weekly. the host defense evaluations included measurement of the number of adherent macrophage precursors per milliliter of blood (monocyte adherence), serum lysozyme, and antibody-dependent cell-mediated cytotoxicity (adcc) of peripheral blood mononuclear cells to c ...	1981	6941048
mechanism of action of bcg-tumor cell vaccines in the generation of systemic tumor immunity. i. synergism between bcg and line 10 tumor cells in the induction of an inflammatory response.	the intradermal injection of a vaccine composed of 10(7) x-irradiated, syngeneic hepatocarcinoma line 10 (l10) cells admixed with 10(8) mycobacterium bovis strain bcg into inbred sewall wright strain 2 guinea pigs induced a local acute and then chronic inflammatory response. cellular analysis of enzymatically dispersed dermal vaccination sites and regional lymph nodes revealed quantitative differences between the cellular infiltrate induced by a mixed bcg-tumor cell vaccine and the inflammation ...	1981	6944552
dose, route, and time dependence of serum lysozyme and antitumor activity following administration of glucan, corynebacterium parvum, pyran, or lipopolysaccharide to mice.	following the administration of di luzio particulate glucan, corynebacterium parvum, pyran (maleic anhydride vinyl ether 6), and lipopolysaccharide (shigella) to inbred c57bl/6j mice, dose, route, and time-dependent studies were undertaken on antitumor activity and serum lysozyme levels to explore the possible relevance of serum lysozyme as a useful index of antitumor activity. antitumor activity was assessed by measurement of the extent of loss of iv injected 125i-labeled 5-iodo-2'-deoxyuridine ...	1981	6944557
enhancement by immunostimulants of the production by mouse spleen cells of factor(s) stimulating differentiation of mouse myeloid leukemic cells.	mouse myeloid leukemic ml cells can be induced to differentiate into macrophages and granulocytes in vitro by a factor(s) stimulating differentiation of the cells (d-factor) or by various chemical compounds. spleen lymphocytes and spleen macrophages have been shown to produce d-factor when treated with various mitogens including lipopolysaccharide or synthetic double-stranded polyribonucleotide, poly(i) . poly(c). several immunostimulants from microorganisms were tested for ability to induce dif ...	1981	6951792
a comparison of the toxicity of two formulations of corynebacterium parvum in a double-blind crossover trial in patients with bronchogenic carcinoma.		1981	7044635
inhibition of lipase production in propionibacterium acnes by sub-minimal-inhibitory concentrations of tetracycline and erythromycin.		1981	6786318
in vitro cytotoxicity expressed by cells active against established tumors in vivo.	although antitumor activity by host cells has been documented in vivo and in vitro, the cellular relationships between these two classes of studies are not clear. cells capable of causing the regression of solid tumors are generated in lymph nodes draining sites of immunization with corynebacterium parvum:irradiated p815 mastocytoma admixtures. these cells are active in a 51cr release assay at a low effector:target ratio producing a characteristic low level of specific 51cr release which require ...	1981	6788359
phagocytic and chemiluminescent responses of mouse peritoneal macrophages to living and killed salmonella typhimurium and other bacteria.	in the presence of luminol, resident as well as thioglycolate-induced and immunized macrophages emitted chemiluminescence more efficiently when the cells were exposed to living salmonella typhimurium than when they were exposed to the same bacterium killed by ultraviolet light or heat. this phenomenon was observed whether or not the bacterium was opsonized. the different response to living and killed bacteria was also found with escherichia coli, pseudomonas aeruginosa, proteus morganii, and ent ...	1981	6788707
prostaglandins and host defense in cancer.		1981	6792432
[effect of the age of the mouse on the action of corynebacterium parvum in inhibiting the growth of 2 syngenetic tumors].	the antitumor properties of corynebacterium parvum have been studied in mice of different ages of two inbred strains: xvii mice and c3h mice grafted with syngeneic tumors. the antitumor protection was very weak in young mice: no effect on mortality rate, only an increase in mean survival time was observed. the highest level of protection was obtained in 2-5 month old mice (100% of survival) in aged mice this antitumor protection decreases more rapidly in c3h mice than in xvii mice. it is interes ...	1981	6794870
[inhibitory effect of arginine butyrate on the development of crocker 180/tg tumor in swiss mice].	arginine butyrate slightly increases the resistance of swiss mice to allografted 180/tg tumor cells. a single injection of corynebacterium parvum has comparable effects. however, it they are associated, survival rate is significantly augmented.	1981	6797689
the role of propionibacterium acnes in the pathogenesis of acne.		1981	6456241
enzyme activities in spleen lymphocytes of tumor-bearing rats, and effect of propionibacterium acnes, bcg, and toxohormone on the enzyme activities in spleen lymphocytes of rats.		1981	6453649
modulation of suppressor mechanisms in allergic contact dermatitis: 1. effect of c. parvum on the induction phase of contact allergy.	the effect of a pretreatment with corynebacterium parvum (c. parvum) on contact allergy in balb/c mice was studied. mice sensitized with 50 microliter (supraoptimal dose) 2.4-dinitrofluorobenzene (dnfb, 0.5%) showed a suppressed response as measured by ear swelling after painting the right ear with 0.3% dnfb in comparison to an allergic response obtained with an optimal sensitization dose (15 microliter dnfb 0.5%). by transfer of spleen cells from donors sensitized with a supraoptimal or an opti ...	1981	6453904
reduction of bacterial skin flora during oral treatment of severe acne with 13-cis retinoic acid.		1981	6454395
acne vulgaris: therapy directed at pathophysiologic defects.	an effective therapeutic regimen for the treatment of acne vulgaris is presented. the emphasis is based upon correcting a defect in keratinization of the sebaceous follicles with a combination of vitamins a and e. this prevents the formation of milia and comedones, thus depriving the propionibacterium acnes of a culture medium. vitamin e also prevents irritating lipid peroxidation of sebum, damaged by bacterial growth, which may be responsible for the inflammatory aspects of acne. no antibiotics ...	1981	6455256
[physiopathological mechanisms in acne vulgaris].	the physiopathological mechanisms of the different degrees of the acne vulgaris are reviewed. the observations show the important antigenic activity of the "propionibacterium acnes" and the cellular immunity in the inflammation. an immunologic concept could explain this process.	1981	6457226
[immunology in surgery].		1981	6457260
activation and mechanism of action of suppressor macrophages.		1981	6457695
immunosuppression of marrow b lymphocytes by administration of corynebacterium parvum in mice.		1981	6457877
modulation of suppressor mechanism in allergic contact dermatitis. iv. selective inhibition of suppressor t-lymphocytes by serum obtained from corynebacterium parvum treated mice.	we have previously shown that corynebacterium parvum treatment reduced tolerance induced by intravenous injection of 2,4-dinitrobenzene sulfonic acid (dnbso3) or by sensitizing balb/c mice with a supraoptimal dose of 2,4-dinitrofluorobenzene (dnfb). further analysis by transfer experiments revealed that the generation and/or functional expression of suppressor t-lymphocytes (ts-cells) was inhibited in both tolerance models. inhibition of ts-cells was not entirely correlated with suppression of m ...	1981	6458637
hybrid resistance to el-4 lymphoma cells. ii. association between loss of hybrid resistance and detection of suppressor cells after treatment of mice with 89sr.	(c57bl/6 x dba/2)f1 hybrid (b6d2f1) mice resist the growth of parental-strain (b6) el-4 lymphoma cells inoculated intraperitoneally; that is, b6d2f1 mice survive longer than b6 mice and do not develop ascites. as compared with b6 mice, b6d2f1 mice have higher levels of natural killer (nk) activity against 51cr-labelled el-4 cells in their lymphoid organs. b6d2f1 mice treated with 89sr lose nk activity for certain lymphoma cell targets, e.g. yac-1, but nk(el-4) function is usually intact. however ...	1981	6458878
neuraminidase production by propionibacterium acnes-strains isolated from patients with acne vulgaris, seborrheic eczema and healthy subjects.	among cutaneous propionibacteria, synthesis of neuraminidase is highest in strains of the species p, acnes. in the present study, neuraminidase activity was discovered in 90.0% of p. acnes strains isolated from acne lesions compared with 72.7% of strains from normal human skin. neuraminidase-positive strains from acne lesions, moreover, produced statistically significant higher amounts of the enzyme (x = 727 microunits/ml bacterial suspension) than isolates from normal skin (x - 392 microunits/m ...	1981	6458977
follicular ph and the development of acne.		1981	6460005
immunomodulation by cancer chemotherapeutic agents and antineoplastic activity.		1981	6460217
[pathomechanism of acne vulgaris].		1981	6460271
development of a bioassay for anti tumor activity of biological response modifiers of the reticuloendothelial stimulant class: reproducibility of the bioassay.	intravenously administered diluzio glucan, wellcome c. parvum, and glaxo bcg caused dose dependent increases in the tumor cell loss from the lungs of c57bl/6j and dba/2j mice challenged respectively with intravenous 125iudr labelled b16 or t 1699 mammary carcinoma cells. the results were reproducible with respect to the optimal doses and the magnitudes and shapes of the dose response curves.	1981	6752286
contribution to the interpretation of the occurrence of unsuccessful therapeutical results in acne vulgaris with topical erythromycin (propionibact. acnes).	investigations are reported which attempt to contribute towards an understanding of those cases in which topical treatment with erythromycin is unsuccessful. in 13 acne patients no resistance of p. acnes was observed after seven weeks of topical treatment with erythromycin. this demonstrates that the 20% frequency of resistance induction reported in the literature is too high. in the 13 treated patients there was no essential reduction in the number of inflammatory lesions although a decrease in ...	1981	6452774
is acne a bacterial disease?		1981	6453166
modulation of suppressor mechanisms in allergic contact dermatitis: 2. inhibition of suppressor t-lymphocytes by corynebacterium parvum.	pretreatment of balb/c mice with corynebacterium parvum inhibited the induction of tolerance to the contact sensitizing agent 2,4-dinitrofluorobenzene induced by intravenous injection of dnbso3. the suppressive effect on tolerance induction has further been analyzed by adoptive transfer experiments. injection of c. parvum intraperitoneally (0.7-2.8 mg/mouse) before injection of the tolergen inhibited the generation of t-suppressor cells as shown by transfer of spleen cells from the tolerized don ...	1981	6453168
in vitro cytochemical and cytophysiological study of in vivo activated mouse peritoneal macrophages.	the morphological, cytochemical (acid phosphatase activity) and cytophysiological (phagocytosis) features of mouse peritoneal macrophages activated in vivo by two bacterial agents. corynebacterium parvum parvum and polidin, were investigated in vitro. both immunostimulants induced an increase in cytochemical and phagocytic activities of the activated peritoneal macrophages but in different degrees, the changes being more extensive in the case of corynebacterium parvum-activated macrophages.	1981	6460939
in vitro augmentation of rat natural killer (nk) cell activity.	in vitro augmentation of rat natural killer (nk) cell activity was produced by 2 types of treatment. increased activity occurred "spontaneously" when spleen cells were cultured alone at 37 degrees c. this augmentation was dependent on the presence of adherent, phagocytic cells, presumably macrophages, and was independent of lps of fcs. normally low levels of nk activity, present in macrophage-depleted cultured cells, could also be boosted in vitro by incubation with corynebacterium parvum. this ...	1981	6451648
proliferative glomerulonephritis in mice given intravenous corynebacterium parvum.	mice given a killed suspension of corynebacterium parvum (c.p.) developed nephritis as part of an immune complex disease. the nephritis was dose-related. after a single dose of 70 microgram (a human-equivalent dose) or of 466 microgram there was a mesangiopathic glomerulonephritis and after repeated human-equivalent doses there was a mesangiocapillary glomerulonephritis. antibodies to c.p. increased and circulating immune complexes were detected. mice receiving repeated doses also developed an a ...	1981	6451676
suppressor t cells and suppressor macrophages induced by corynebacterium parvum.		1981	6452218
observations on the nature of the determinants in anaerobic coryneforms which produce splenomegaly.		1981	6259348
enhanced chemiluminescence production by purified macrophage monolayers from c. parvum-treated mice.	chemiluminescence (cl) of both corynebacterium parvum (c. parvum) and saline elicited murine peritoneal macrophage monolayers was studied employing a luminol-dependent assay. glycogen-induced macrophages were obtained from animals that had been injected 7-10 days previously with either c. parvum or phosphate buffered saline (pbs). peritoneal exudate cells (3 x 10(6)) were allowed to attach to an 18 mm diameter glass cover slip, and then were cultured an additional 20-24 hr. the cover slips were ...	1981	6262276
lasting engraftment of histoincompatible bone marrow cells in dogs.	conditioning protocols were tested for their efficacy in increasing the incidence of engraftment of histoincompatible dog bone marrow cells. cyclophosphamide and total body irradation (tbi), corynebacterium parvum and tbi, a 3- or 5-day delayed transfusion of bone marrow cells after tbi, or an increase in the number of donor bone marrow cells or lymphocytes appeared to be ineffective. these protocols were previously reported to promote recovery of splenic hemopoiesis in mice in short-term assays ...	1981	6262956
chemoimmunotherapy of small cell bronchogenic carcinoma with vp-16-213, ifosfamide, vincristine, adriamycin, and corynebacterium parvum.	thirty-five consecutive patients with small cell bronchogenic carcinoma (scbc) received chemoimmunotherapy with vp-16-213, ifosfamide, vincristine, adriamycin, and corynebacterium parvum. of 33 evaluable patients, 26 (79%) responded with complete (55%) or partial (24%) remissions. complete remissions were more common among patients with limited disease (11/14 patients, 79%) compared with those with extensive disease (7/19 patients, 37%) and among patients (11/14 patients, 79%) compared with thos ...	1981	6263454
detection of either rapidly cytolytic macrophages or nk cells in "activated" peritoneal exudates depends on the method of analysis and the target cell type.	the nature of the cytotoxic cells present in the peritoneal cavity of rats treated with bacille calmette-guérin (bcg) or corynebacterium parvum was investigated using a 6 hr chromium release assay and a quantitative method of analysis based on consideration of target-cell killing as an enzyme-substrate reaction. when the results of cell-fractionation experiments were evaluated in terms of recovery of total lytic units and when appropriate target cells (such as sarcoma mc7) were used, the simulta ...	1981	6263794
activated macrophages mediate interferon-independent inhibition of herpes simplex virus.		1981	6164494
role of macrophage in in vitro augmentation of rat, mouse, and human natural killer activities.	requirement for macrophages in in vitro augmentation, by interferon (ifn), polyinosinic-polycytidylic acid (poly i:c), or corynebacterium parvum, of rat, mouse, and human natural killer (nk) activities was examined. several differences were seen among the species. mouse nk activity demonstrated some lability at 37 degrees c and a strict macrophage requirement for in vitro production of ifn, and augmentation of nk activity was demonstrated by either poly i:c or c. parvum. in contrast, human perip ...	1981	6164813
protection of mice against mouse hepatitis virus by corynebacterium parvum.	c57bl/6 mice that are highly susceptible to infection with mouse hepatitis virus type 3 were protected against intraperitoneal viral infection by simultaneous intraperitoneal injection of corynebacterium parvum. no protection was observed when c. parvum was given intravenously or when it was injected intraperitoneally 3 days before viral infection. protective effects were, however, consistently found when c. parvum was given 2 h before or 2 h after viral infection. activity was seen only against ...	1981	6166566
the effect of benzoyl peroxide on acne.	a double-blind study of two commonly used (5%) benzoyl peroxide-containing preparations showed that they were equally effective in the treatment of acne. with these treatments there was a reduction in p. acnes, micrococcaceae and surface-free fatty acids. these data support the continued use of benzoyl peroxide preparations in the treatment of acne.	1981	6167116
the relationship between bacteria and the abnormal follicular keratinization in acne vulgaris.	the structural organization and bacteriological profile of follicular casts and early comedones in prepuberal children were investigated. follicular casts were present in all samples but were not as abundant as usually seen in older individuals with acne. when examined with the light microscope, all casts and comedones were composed of numerous layers of horny cells and sebum, but were devoid of bacteria. neither follicular casts nor comedones yielded bacteria when cultured. electron microscopy ...	1981	6167647
intraperitoneal administration of corynebacterium parvum in patients with ascitic ovarian tumors resistant to chemotherapy: effects on cytotoxicity of tumor-associated macrophages and nk cells.		1981	6168590
bacteriologic investigation and histologic observations of variably acid-fast bacteria in three cases of cutaneous kaposi's sarcoma.	skin biopsy specimens from 3 consecutive patients with lesions of kaposi's sarcoma limited to the skin were cultured for bacteria, and also examined histopathologically for the presence of acid-fast wall deficient (cwd) bacteria. corynebacterium sp and propionibacterium acnes were isolated from two repeated cultures from the first case. both staphylococcus epidermidis and streptococcus viridans were isolated from the second case. bacteriologic culture of the third case was negative. utilizing th ...	1981	6169593
the induction of at least two distinct types of interferon in mouse spleen cell cultures by corynebacterium parvum.		1981	6170460
immunotherapy of sarcomas.	numerous attempts have been made at immunotherapy of sarcomas in man, and in most of these, tumor cells were used as a source of antigen. the cells were given by direct immunization with an adjuvant such as bcg or in adoptive immunotherapy trials in which tumor-immunized donors were a potential source of immune cells. these series of studies have shown consistent evidence of effect on the immune response of the patients to tumor antigens but no consistent clinical effect. nonspecific immunothera ...	1981	6170891
effect of immunostimulating agents on viral infections.		1981	6171144
a comparison of the antiproliferative and antiviral activities of alpha-, beta- and gamma-interferons: description of a unified assay for comparing both effects simultaneously.	an assay system is described which allows simultaneous measurement of antiviral (av) and antiproliferative (ap) activities of various interferons (ifns) with the same indicator cells and tests one biological function, i.e. the reduction of dna synthesis. human ifn-alpha, -beta, and -gamma preparations were investigated for their respective av and ap activities. in repeated independent experiments the ap:av ratio was found to be constant for each ifn preparation. however, striking difference in t ...	1981	6174633
specific unresponsiveness to corynebacterium parvum as measured by delayed hypersensitivity.	in order to induce specific unresponsiveness to c. parvum mice were given seven daily i.v./i.p. injections of a high dose of the vaccine, or were given a single dose i.v. injection of c. parvum followed by an i.p. injection of cyclophosphamide (cy). mice given the high-dose procedure had a significant level of residual footpad reactivity to c. parvum challenge, but subsequent sensitizing injections did not stimulate delayed hypersensitivity (dh). in contrast, mice given c. parvum and cy did not ...	1981	6176532
immunopotentiation of allergic contact dermatitis in the guinea pig with c. parvum (p. acnes).		1981	6177174
labeling and distribution of technetium-99m corynebacterium parvum as determined by whole-body imaging.		1981	6266643
cellular basis for the loss of carcinogen from methylcholanthrene-impregnated millipore membrane.	millipore 'discs' impregnated with methylcholanthrene dissolved in wax or in crystalline form implanted subcutaneously in mice evoke an early intense macrophage and giant cell reaction; later the discs become covered with connective tissue, and eventually fibrosarcomas develop in their vicinity. studies with tritium-labelled material show that under these conditions methylcholanthrene (mc) is removed from the discs and broken down rapidly (half life about 7 days) to a water-soluble product, whic ...	1981	6111799
in vitro reactivity of natural killer (nk) cells against cryptococcus neoformans.		1982	6120974
transplantation model for study of microbiology of human skin.		1982	6124748
an enumeration of black-pigmented bacteroides in human subgingival material using a selective medium.		1982	6125274
distribution of surface fimbriae in species of the genus propionibacterium.		1982	6129070
effect of corynebacterium parvum-mediated inhibition of lymphocyte proliferation on the effector- and suppressor-lymphocyte response in contact allergy.		1982	6223601
inhibition of experimental tumor metastasis by selective activation of natural killer cells.	the antitumor activity generated by selective activation of natural killer (nk) cells was studied in vitro and in vivo. unlike corynebacterium parvum cn6134, which activated both nk cells and macrophages, periodate-oxidized c. parvum cn6134 lost the ability to activate macrophages but retained almost all the nk-stimulating capacity of the untreated bacterium. the "inactive" c. parvum strain cn5888 also induced a modest, but selective, activation of nk cells. the enhanced nk cell-mediated cytotox ...	1982	6277482
inability of tumour cells to elicit the respiratory burst in cytotoxic, activated macrophages.	activated macrophages from corynebacterium parvum-treated mice are cytotoxic to non-antibody-coated tumour cells and have an augmented respiratory burst potential when compared to resident macrophages. we have investigated the possible involvement of the respiratory burst as an effector mechanism in this type of tumour killing. scavengers of toxic metabolites of oxygen such as catalase, superoxide dismutase, 2,3-dihydroxybenzoate, ethanol, and cytochrome c did not inhibit macrophage cytotoxicity ...	1982	6277777
the pulmonary clearance of pasteurella haemolytica in calves given corynebacterium parvum and infected with parainfluenza-3 virus.	four control calves were aerosolized with parainfluenza-3 and one week later with pasteurella haemolytica. three calves were given corynebacterium parvum at a dose of 15 mg/m2 body surface area, infected with parainfluenza-3 virus one week later, and aerosolized with p. haemolytica two weeks after c. parvum injection. all calves were killed four hours after p. haemolytica exposure and the bacterial retention in the lung was determined. parainfluenza-3 viral infection did not exert any suppressiv ...	1982	6280824
immunization of cattle with a variant-specific surface antigen of trypanosoma brucei: influence of different adjuvants.	nine different adjuvants were examined for their ability to potentiate the humoral and cell-mediated immune responses of cattle to a soluble glycoprotein antigen prepared from trypanosoma brucei. serological responses as measured by the farr assay were best augmented by the oil-based adjuvants and saponin. cell-mediated immunity, as assessed by specific lymphocyte transformation in vitro, was enhanced by all oil-based adjuvants at different intervals after immunization. results from a challenge ...	1982	6281183
chemotherapy versus chemoimmunotherapy with levamisole or corynebacterium parvum in advanced lung cancer.	a total of 109 patients with advanced lung cancer, all cell types, were randomized between macc chemotherapy only, consisting of methotrexate, doxorubicin (adriamycin), cyclophosphamide, and lomustine (ccnu); macc plus levamisole (lms) orally; and macc plus corynebacterium parvum (cp) sc. of these patients, 101 were evaluable, with no differences among the three treatment groups for overall response rate and survival time. objective response rates and median survival times were 41% and 230 days ...	1982	6282455
[antibiotic resistance of anaerobic bacteria (author's transl)].	reference data on the overall resistance patterns of anaerobic bacteria are needed since in individual clinical cases susceptibility testing is complicated by the long generation time and difficulties of test conditions. benzylpenicillin and tetracyclines are the drugs of choice against clostridium perfringens. newer cephalosporins are also active, whereas other clostridium species have been found resistant. beta-lactam antibiotics show high activity against peptococcaceae; resistance to clindam ...	1982	6286503
activation of epstein-barr virus expression in human lymphoblastoid p3hr-1 and raji cells with propionic acid and with culture fluids of propionic acid-producing anaerobes.	epstein-barr virus (ebv)-associated early (ea) and virus capsid antigens (vca) were efficiently induced in the viral genome-carrying human lymphoblastoid cells, p3hr-1 and raji, by the culture fluids of propionibacterium acnes, p. avidum, p. lymphophilum and arachnia propionica, the anaerobes which are commonly seen among the normal flora of man. the active principle for ebv-induction in the 2 cell lines was the propionic acid produced by the microbes and such activity was shown to correlate wit ...	1982	6290028
resistance to infections in mice with defects in the activities of mononuclear phagocytes and natural killer cells: effects of immunomodulators in beige mice and 89sr-treated mice.	beige mice, which are a homolog of the chediak-higashi syndrome, and mice treated with 89sr to destroy the bone marrow provide animal models of defects in mononuclear phagocyte and natural killer cell functions. the innate resistance of these mice to viruses such as herpes simplex and encephalomyocarditis viruses, however, is normal. moreover, treatment of the mice with immunomodulators such as propionibacterium acnes (formerly designated corynebacterium parvum) and pyran produced a significant ...	1982	6290389
fate of vaccines of propionibacterium acnes after phagocytosis by murine macrophages.	stationary-phase (48 h) cells of propionibacterium acnes vpi 0009, a potent stimulator of the reticuloendothelial system, persist unchanged within phagocytes for at least 24 h after ingestion. in contrast, exponential-phase (12 h) cells of the same strain (which do not induce splenomegaly) are extensively degraded within 5 h of phagocytosis. suspensions of p. granulosum vpi 6500, which fails to induce splenomegaly in mice, also show considerable degradation after phagocytosis. stationary-phase c ...	1982	6292096
accessory cell function in tumor-bearing mice and effects of corynebacterium parvum.	primary in vivo production of antibody to sheep red blood cells (srbc) was consistently suppressed in el 4 tumor-bearing c57bl/6 mice, but the secondary response was not suppressed. this suppressed primary in vivo production of antibody was partially restored by systemic administration of corynebacterium parvum. for investigation of the mechanism of the immunosuppression in tumor-bearing mice and the effects of c. parvum, the accessory cell function of adherent cells from tumor-bearing mice and ...	1982	6292563
[immunotherapy of lung cancer].		1982	6292882
modulation of antitumor immunity--immunobiologic approaches.		1982	6293113
mechanisms of action by immunologic adjuvants.		1982	6294032
enhancement of concomitant immunity after radiation therapy and immunotherapy in a syngeneic murine tumour system.	concomitant immunity was evaluated in vivo towards a chemically induced epidermoid carcinoma transplanted in a syngeneic situation. radiation therapy reversed the declining phase of concomitant immunity associated with tumour progression. the rejection rate of a challenge graft amounted to 82 and 95 per cent, respectively, 2 and 8 days after 25 gy as compared with 55 and 43 per cent in unirradiated controls. radiation induced immune recovery was dose related and proved to be different from resto ...	1982	6297254
[antibacterial effects of niridazole. ii. effects on aerobic and anaerobic bacteria].	niridazole which is chemically related to metronidazole is endowed with much better antibacterial activity. first, several genera of aerobic bacteria, such as salmonella and escherichia, are susceptible to niridazole, whereas metronidazole is completely ineffective. there exist, however, some particular strains which are naturally resistant to niridazole. the in vitro activity of niridazole is still increased, if these facultative anaerobic bacteria are tested under anaerobic growth conditions. ...	1982	6299027
effect of cyclosporin a on the production of interferon by human peripheral blood leukocytes in vitro.	cyclosporin a (csa) was assessed for its effect on the production of antiviral activity by human peripheral blood leukocytes (pbl). csa markedly reduced the production of interferon-gamma (ifn-gamma) in response to stimulation with lectin mitogens, bacterial products, alloantigens, or epstein-barr virus (ebv)-transformed lymphoblastoid cell lines (lcl). csa-mediated suppression of ifn-gamma secretion was dose-dependent and did not result from a shift of kinetics of the production of antiviral ac ...	1982	6299190
murine lymph node natural killer cells: regulatory mechanisms of activation or suppression.	the kinetics and organ distribution patterns of lymph node natural killer (nk) cell activation or suppression were found to vary according to the type, dose, and route of administration of corynebacterium parvum or polyinosinic-polycytidylic acid (poly i . poly c). activation of lymph node nk cells by local injections of c. parvum into the footpad or the peritoneum was restricted to the regional lymph nodes; contralateral and distant lymph nodes were not involved. this selectivity persisted even ...	1982	6180211
interferons and bacterial infections.	viruses have been established initially as interferon inducers and interferons have been considered to be antiviral proteins only. by our article we wish to draw attention to two observations: a) bacteria and derivatives thereof also are inducing the production of interferon b) interferons activate a number of defense mechanisms that are of potential relevance in antibacterial resistance. these two observations are not new. however, we believe, they deserve renewed attention within the framework ...	1982	6181288
antitumor effect of arginine butyrate in conjunction with corynebacterium parvum and interferon.	the antitumor effect of arginine butyrate, used alone or in conjunction with interferon (ifn), was studied using randomly selected swiss mice inoculated i.p. with 10(6) 180 tg crocker tumor cells. the results of these different therapeutic regimens were estimated by tumor incidence at 10 days, by the time necessary to protect 50% of the animals, and by the final survival rate. combined treatment by ifn and arginine butyrate was effective; but in order to compensate for ifn's immune repressive ef ...	1982	6183228
modulation of suppressor mechanisms in allergic contact dermatitis: 5. evidence that inhibition of suppressor t lymphocytes by corynebacterium parvum is mediated by interferon.	using a contact hypersensitivity model in balb/c mice we have previously been able to show that corynebacterium parvum or c. parvum serum (c.p.s.) of mice treated 24 hr before with c. parvum inhibited the suppressor t-lymphocyte (ts-cell) response induced by epicutaneous antigen overload with 2,4-dinitrofluorobenzene (dnfb) or by i.v. injection of 2,4-dinitrobenzene sulfonic acid (dnbso3) without inhibition of the t effector cell response (tdh-cell). in the present investigation we further analy ...	1982	6183368
treatment of advanced renal cell carcinoma.		1982	6183675
endotoxin-induced release of tumour necrosis factor and interferon in vivo is inhibited by prior adrenoceptor blockade.	the effect of alpha- and beta-adrenoceptor blocking agents on endotoxin-induced release of tumour necrosis factor (tnf), and of interferon in the circulation of corynebacterium parvum-treated mice was the subject of this study. tnf was quantified after injection of tnf containing heated serum (tns) into meth a sarcoma-bearing mice by determining colour, extent, and incidence of haemorrhagic necrosis. the release of tnf was weakly inhibited by the competitive alpha-blocker phentolamine and the be ...	1982	6186366
the efficacy of a topical preparation containing erythromycin in the treatment of acne.		1982	6212272
clinical use of a selective culture medium for wild and antibiotic-resistant propionibacterium acnes.		1982	6212602
effects of different fractions of corynebacterium parvum on the cytotoxic t-cell response to alloantigens in mice.	the effects of several biochemically derived fractions of corynebacterium parvum and chemically treated intact organisms on the generation of cytotoxic t-lymphocytes (ctl) were assessed in a tumor allograft model with the use of c57bl/6 and dba/2 mice. the acid-modified, active and inactive fragmented preparations and pyridine extract and residue were all capable of inhibiting primary spleen cell allocytotoxicity. only the active fragmented, pyridine residue and unfractionated preparations cause ...	1982	6213807
evaluation of topical erythromycin and oral tetracycline in acne vulgaris.	a double-blind study was conducted to compare topical erythromycin 1.5 percent solution (staticin solution) with oral tetracycline (250 mg) twice a day in fifty-four patients with grades ii and iii acne vulgaris. although both therapies produced a statistically significant reduction in the number and severity of the acne lesions, the topical preparation usually showed an effect earlier and to a greater degree than the oral medication. by the end of the study, some of these differences were stati ...	1982	6214377
[cytotoxicity in acne vulgaris].	three cellular cytotoxic lymphocytary populations were studied in patients with different forms of inflammatory acne vulgaris: direct or spontaneous, antibodies dependent and phytohemagglutinine stimulated. to these was added "propionibacterium acnes" from cultures of material extracted separately from comedones and pustules. the direct or spontaneous and antibodies dependent cytotoxicity were normal. the subpopulation responsible of the phytohemagglutinine stimulated cytotoxicity has shown a cl ...	1982	6214674
comedonal levels of free clindamycin following topical treatment with a 1% solution of clindamycin phosphate.	comedones were extracted from twenty subjects using topical 1% clindamycin phosphate and were assayed for free clindamycin. positive specimens were obtained from sixteen subjects at 2 weeks and from eighteen at 4 weeks, with levels of 0.06 to 1.49 micrograms/mg. mean content was 0.39 +/- 0.08 micrograms/mg and 0.6 +/- 0.11 micrograms/mg, respectively. these values closely match levels previously determined following treatment with clindamycin hydrochloride, which may explain how these two esters ...	1982	6215433
high-level induction of gamma interferon with various mitogens in mice pretreated with propionibacterium acnes.	various t-cell mitogens induced high levels of circulating gamma interferon (ifn-gamma) in mice that had been pretreated with propionibacterium acnes. administration of lipopolysaccharide, a b-cell mitogen, to these mice also caused pronounced production of ifn-gamma in addition to ifn-alpha and ifn-beta. the enhanced induction was most marked at about 1 week after the pretreatment.	1982	6216215
osteomyelitis of cervical spine from propionibacterium acnes.		1982	6461331