Publications

effect of antibiotics on the prevention of experimental bacteroides fragilis endocarditis.	the relative efficacy of single doses of antibiotics in modifying the development of bacteroides fragilis subsp. fragilis endocarditis was studied in an experimental model. antibiotics were administered 0.5 h before intravenous injection of b. fragilis subsp. fragilis into rabbits prepared by insertion of a polyethylene catheter into the left side of the heart; 48 h later, intracardiac vegetations were excised and cultured anaerobically. b. fragilis was recovered from 92% of untreated animals. a ...	1978	727764
anaerobic bacteria: evaluation of disc susceptibility to four cephalosporins.	the disc diffusion technique was evaluated with 178 strains of anaerobes and four cephalosporins (cephalothin, cefamandole, cefazolin and cefoxitin). good correlation in results was found in comparison with the agar dilution technique (p less than 0.001) with the exception of cefamandole and cefazolin against anaerobic cocci (p greater than 0.05). choosing a breakpoint of 8 microgram/ml for distinguishing susceptible and resistant strains, we determined corresponding incubation, the rate of erro ...	1978	730395
factors affecting production of catalase by bacteroides.	several variables affected the production of catalase by members of the "bacteroides fragilis group" of anaerobic bacteria. both media yielded higher catalase levels than the respective agar media. addition of hemin to media after autoclave sterilization, rather than before, significantly increased production of catalase. both of these variables could be related to the available hemin concentration present in the medium being tested. significantly higher amounts of hemin were required for catal ...	1978	730827
differentiation of bacteroides fragilis species by gas chromatographic detection of phenylacetic acid.	of 382 strains tested, 261 strains of the species bacteroides fragilis, b. thetaiotaomicron, b. ovatus, and b. distasonis produced phenylacetic acid; the remaining strains, belonging exclusively to the species b. vulgatus, failed to do so. this differentiation characteristic may be useful in routine clinical bacteriology.	1978	730830
[peritoneal drainage without antibiotics (author's transl)].	the mortality of generalized peritonitis in serious. the drainage of the peritoneal cavity for diffuse peritonitis is essential but difficult, and it should be combined with peritoneal lavage. the drainage system must be properly adapted to the intraperitoneal liquid circulation. the local use of antibiotics is not indicated. systemic administration is obvious, because in about 80% of cases, it is an anaerobic infection with bacteroides fragilis, a dreadfully tough organism, which impairs the fu ...	1978	732452
activity of sulfamethoxazole trimethoprim against bacteroides fragilis.	the author tested parallely 35 bacteroides fragilis strains by the agar diffusion method and disk technique. a notable discrepancy appears between these two procedures. no regression line can be constructe and the inhibition diameter measurement is unable to class the strain in "susceptible" or "resistant". a literature review on this theme shows that the dissociation between these two techniques were more frequent with anaerobic strains than aerobic for smx + tmp as others antibiotics. the mic ...	1978	735555
anaerobic susceptibility tests. evaluation of the stability of antimicrobials in wilkens-chalgren broth and the effect of media prereduction.	the stability of eight antimicrobial agents in wilkens-chalgren broth was evaluated. the activities of only carbenicillin and benzyl penicillin were significantly decreased after storage for eight weeks at--20 degrees c. anaerobic reduction of the susceptibility testing broth prior to inoculation was found to be unnecessary.	1978	738968
diagnosis of bacteroides fragilis infection with counter-immunoelectrophoresis.	in a study of 188 patients and 109 controls, the detection of antibody by counterimmunoelectrophoresis was used as a diagnostic aid in human infections with bacteroides fragilis. it was found that positive results indicated current infection and negative results were not conclusive. the method used was simple, rapid, and easily performed in a routine laboratory, but further work is needed to enhance antigen potency.	1978	739053
serological diagnosis of bacteroides fragilis infections by a complement fixation test.	paired specimens of serum from patients from whom bacteroides fragilis had been isolated were tested by complement fixation against a crude b. fragilis antigen. a high titre or a rise in titre to b. fragilis was obtained in each of five patients with infection after abdominal surgery but in none of 11 patients with postpartum pyrexia nor in nine with vaginitis.	1978	739054
isolation of auxotrophs of bacteroides fragilis.	techniques employing ethane methanesulfonate and modified penicillin enrichment were developed whereby auxotrophs of bacteroides fragilis could be readily isolated. several auxotrophic phenotypes are described.	1978	747821
simple method for detection of penicillinase-producing neisseria gonorrhoeae.	a simple, reliable, and economical method for detection of penicillinase-producing neisseria gonorrhoeae using a penicillin disk and a penicillin-sensitive organism is described.	1978	415067
surgical treatment of valvular heart disease.		1978	415632
septic induced acute gastric erosions: the role of cimetidine.		1978	417217
colonization resistance against potentially pathogenic bacteria in hexaflora-associated gnotobiotic mice.	a study of colonization resistance against potentially pathogenic bacteria (escherichia coli and pseudomonas aeruginosa) was conducted in hexaflora-associated gnotobiotic mice. groups of germfree akr mice were swabbed with five bacterial and a single gastrointestinal yeast species: streptococcus faecalis. lactobacillus brevis. staphylococcus epidermidis, enterobacter aerogenes, bacteroides fragilis var. vulgatus, and torulopsis sp. all species became established in the gut in 8 weeks. later thes ...	1978	417787
endotoxin in germfree, gnotobiotic, or conventional-flora sprague-dawley rats.	the limulus assay for bacterial endotoxin was performed on serum and (or) plasma from animals monoassociated with clostridium species, staphylococcus aureus, escherichia coli, proteus mirabilis, enterobacter agglomerans, bacteroides fragilis, klebsiella pneumoniae, or candida albicans. plasma from animals monoassociated with the gram-negative bacteria or c. albicans consistently showed a positive limulus test while conventional-flora controls, germfree rats, and gnotobiotic animals monoassociate ...	1978	371771
effect of nutrition on protein turnover in skeletal muscle.		1978	350634
3-hydroxypyruvate substitutes for pyridoxine in serc mutants of escherichia coli k-12.	escherichia coli k-12 mutants with serc genotype required pyridoxine and serine for normal growth, as do e. coli b mutants of this type. mutants of the k-12 strain, however, reverted easily to pyridoxine independence without regaining activity in the 3-phosphoserine oxoglutarate transaminase coded for by the serc gene. both these revertants and the parental type synthesized pyridoxine in normal amounts when 3-hydroxypyruvate was used as a supplement, although neither of these mutants could use t ...	1978	350858
microflora of the cervix during normal labor and the puerperium.	the normal flora of the cervix was studied in 50 healthy women in labor and on the third day postpartum. aerobic bacteria were the exclusvie isolates in 25% of these women, and 75% had anaerobic bacteria in addition to aerobes. anaerobes were always found in association with aerobes. the most frequent isolate of bacteroides was bacteroides melaninogenicus, found in 20% of the women during labor and 14% during the puerperium. bacteroides fragilis was distinctly absent during labor but was found i ...	1978	351071
effects of beta-endorphin on narcotic abstinence syndrome in man.		1978	351136
use of a rapid fermentation test for indentification of anaerobic bacteria.	rapid fermentation tests of carbohydrates were performed on 84 strains of anaerobic bacteria, and the result is compared with a commercially available micromultitest, api. an overall correlation of 87% was achieved between the two systems. the rapid fermentation test is easy to perform, since it is done aerobically, and easy to read. this study shows that rft is useful in routine diagnosis of anaerobic bacteria, if it is used in combination with other relevant biochemical tests, morphologic exam ...	1978	351363
[study of anaphylectic hypersensitivity manifestations to blood protein in guinea pigs with using the neutrophil damage test in vitro].	the paper is devoted to the study of hypersensitivity of anaphylactic type to horse serum in guinea pigs by means of neutrophil injury index in vitro. simultaneously, for control, the same method was applied to the study of delayed hypersensitivity manifestations; for this purpose allergy to hemolytic staphylococcus was reproduced in these animals. the state of hypersensitivity of "anaphylactic type" against the foreign serum in guinea pigs was not accompanied by any enhanced blood neutrophil re ...	1978	352049
[ribosomal dysentery vaccine. i. method of production, physical and chemical properties].	studies of a. and g. youmans on the experimental tuberculosis led to discovery of a fundamentally new type of vaccines (ribosomal vaccines) which proved to be highly effective in the prophylaxis of many experimental infections. therefore it seems reasonable to prepare analogous vaccine from shigellae for the study of its efficiency in experimental shigellosis. ribosomal preparations from shigella sonnei were prepared by sonic disruption of microbial cells followed by differential ultracentrifuga ...	1978	352058
cytologic detection and clinical significance of actinomyces israelii in women using intrauterine contraceptive devices.	pancervicovaginal (papanicolaou) smears exhibiting pseudomycilial-like clumps of organisms obtained from 35 women employing iud's were studied by direct immunofluorescent technique for identification of a. israelii and a. naeslundi. in every case the specific fluorescence was achieved with species-specific antiserum against a. israelii. the clinical profile of these 35 women was retrospectively analyzed.	1978	352150
influenza immunization in lupus erythematosus: safe, effective?		1978	352215
inhibition of pyruvate dehydrogenase multienzyme complex from escherichia coli with mono- and bifunctional arsenoxides.		1978	352396
active immunization of female rats with luteinizing hormone releasing hormone (lhrh).		1978	352412
the bacteriology of cavitating pulmonary infections and empysema. studies of transtracheal aspirates and pleural fluid.	a prospective study of bacteriology in 14 cases of cavitating pulmonary infections and empyema is reported. bacteriologic results were based on transtracheal aspirates or pleural fluid. appropriate anaerobic bacteriologic methods were employed. anaerobic bacteria were recovered in 11 patients (79%); they were the only pathogens isolated in 6 patients. the predominant species were fusobacterium nucleatum, bacteroides melaninogenicus, bacteroides fragilis and peptostreptococcus. aerobic bacteria w ...	1978	352421
stress and hypertension: interrelations and management.		1978	352515
[collective review: salmonella paratyphi in animals and in the environment].		1978	352661
metabolism of 2-deoxy-2-fluoro-d-[3h]glucose and 2-deoxy-2-fluoro-d-[3h]mannose in yeast and chick-embryo cells.	2-deoxy-2-fluoro-d-[3h]glucose and 2-deoxy-2-fluoro-d-[3h]mannose have been prepared by tritiation of the corresponding unlabeled 2-fluoro sugars. the tritiated 2-fluoro sugars are phosphorylated and activated by utp and by gtp to yield udp-2-deoxy-2-fluoro-d-[3h]glucose, udp-2-deoxy-2-fluoro-d-[3h]mannose, gdp-2-deoxy-2-fluoro-d-[3h]glucose and gdp-2-deoxy-2-fluoro-d-[3h]mannose in both cell types. the nucleotide derivatives could also be labeled in the nucleotide moiety by feeding the cells wi ...	1978	352691
localization of luteinizing hormone (lh) and testosterone (t) or dihydrotestosterone (dht) in the gonadotropic cells of the anterior pituitary by using ultra-cryomicrotomy and immunocytochemistry.		1978	352889
nonspecific immunostimulant activities of synthetic trehalose-6,6'-diesters (lower homologs of cord factor).	mycobacterial cord factors (6,6'-diesters of trehalose with mycolic acids ranging from c80 to c90) have been shown to protect mice effectively against infection with klebsiella pneumoniae or with listeria monocytogenes. our present findings indicate that the low-molecular-weight cord factor of corynebacterium diphtheriae (with corynomycolic acids ranging from c28 pto c36) is equally active. moreover, its synthetic analog (with synthetic c32 mycolic acid) has the same activity. two lower syntheti ...	1978	352926
a review. lessons from an animal model of intra-abdominal sepsis.	intra-abdominal sepsis that involves multiple aerobic and anaerobic bacteria derived from the colonic flora was studied in wistar rats to determine the relative roles of various microbial species. the rats challenged with pooled colonic contents showed a biphasic disease. initially, there was acute peritonitis, escherichia coli bacteremia, and high mortality. in rats that survived this acute peritonitis stage, intra-abdominal abscesses developed, and anaerobic bacteria were the preponderant orga ...	1978	354591
influence of bowel preparation and antimicrobials on colonic microflora.	the influence of three types of preoperative mechanical bowel preparation on colonic microflora has been studied in 88 patients undergoing elective bowel resection and compared with 21 controls. neither conventional bowel preparation (cbp) using oral magnesium sulphate, enemas and rectal washouts nor whole bowel irrigation (wbi) via a nasogastric tube influenced the type or number of organisms in the colon at the time of operation. the administration of an elemental diet (ed) was associated with ...	1978	354736
antimicrobial effect of amniotic fluid.	the antimicrobial effect of amniotic fluid (af) obtained during the first (af1) and second (af2) trimesters was compared with the third (af3) against anaerobic bacteria, such as bacteroides fragilis ss. fragilis (6 strains), eubacterium lentum (3 strains), and peptostreptococcus anaerobius (4 strains). escherichia coli (5 strains) served as a positive control. af1 supported the growth of all 4 anaerobes (except b fragilis for 4 hours) for the entire 24-hour period tested. af2 supported the growt ...	1978	355963
newer cephalosporins and cephamycins--a review.	since the introduction of cephalothin and cephaloridine as the first parenteral cephalosporins and cephalexin as the first member of the group which is absorbed from the gastrointestinal tract, several new cephalosporin derivatives have been developed. most of these have no major advantages over cephalothin, cephaloridine or cephalexin. increased knowledge about the importance of beta-lactamases for bacterial resistance against beta-lactam antibiotics has focused interest on development of drugs ...	1978	356183
polymorphonuclear neutrophil chemotaxis under aerobic and anaerobic conditions.	the motility of human polymorphonuclear neutrophils was studied in vitro under aerobic and anaerobic conditions. chemotactic factors were generated from plasma with immune complexes or with whole bacteria (staphylococcus aureus, escherichia coli, and bacteroides fragilis). chemotaxis induced by chemotactic factors generated from immune complexes was identical under both conditions. however, chemotaxis utilizing chemotactic factors generated from bacteria was markedly depressed under anaerobic co ...	1978	357284
the use of intravenous cefoxitin sodium in patients with obstetric/gynaecologic infections.		1978	357395
rabbit polymorphonuclear leukocyte chemotactic factor generated in vivo by bacteroides fragilis lipopolysaccharide. i. isolation and physico-chemical characterization.	by chromatographic separation on sephadex gels a peptide, termed the lipopolysaccharide-induced chemotactic factor (lps-cf), has been isolated from inflammatory exudate. the exudate was obtained from teflon chambers implanted subcutaneously in rabbits 3 h after lps from bacteroides fragilis ss. fragilis had been injected. three chemotactic peaks were eluted by fractionation of the exudate on sephadex g-200 columns; one major peak with molecular weight of approximately 16,000 and two minor peaks ...	1978	358747
pathogenesis of mucosal injury in the blind loop syndrome.	bacterial extracts were prepared from cultures originating in chronic self-filling intestinal blind loops in rats. their ability to remove active maltase molecules from isolated brush border membranes was studied in vitro. twelve strains in 51 tested, belonging to one of three species, bacteroides fragilis, clostridium perfringens, and streptococcus fecalis, possessed maltase-releasing activity. the ability to remove maltase correlated well with the ability to hydrolyze p-nitrophenyl-tert-butylo ...	1978	359400
[predominance of bacteroides of the fragilis group in the fecal flora under the influence of gentamycin and kanamycin].		1978	360322
antibody response in thirteen patients with bacteroides fragilis infections.	13 patients with bacteroides fragilis infections were studied for antibody response against the infecting strain using indirect immunofluorescence (ifl), passive hemagglutination (ha) and tube agglutination (ta). with indirect ifl significant titre changes in igg were found in 12/13 cases, in iga in 8/13 and in igm in 4/13 cases. with passive ha significant titre changes were found in 11/13 cases and with ta in 6/11 cases. the rise in antibody titre was fast and persisted for a long time in most ...	1978	362516
bacteriologic culture results obtained before and after elective midtrimester urea abortion.	twenty patients undergoing elective midtrimester abortion by urea amnioinfusion had bacteriologic culture data obtained before and after the procedure. despite the presence of pathogens in the vagina and cervix prior to the procedure, only 20% of patients exhibited endometrial growth following abortion. factors that seem to favor such endometrial growth include increased injection-abortion intervals and the requirement for curettage to manage incomplete abortion.	1978	363343
the quantitative and histological demonstration of pathogenic synergy between escherichia coli and bacteroides fragilis in guinea-pig wounds.	known numbers of standard strains of escherichia coli and bacteroides fragilis were inoculated together into surgical incision in guinea-pigs. histological and quantitative bacteriological proof is presented that pathogenic synergy occurred in vivo with copious pus formation when combinations of subinfective doses of each organism were inoculated. a further series of experiments showed that the amounts and ratios of e. coli and b. fragilis in the septic inocula were critical, and that the result ...	1978	364068
[susceptibility testing of anaerobes (author's transl)].	the methodology of susceptibility testing of anaerobes has not yet been standardized and many individual test methods are in use. among the factors which may influence the outcome of susceptibility tests are test organisms, antimicrobials and methods of susceptibility testing. comparative studies have shown that the density of the inoculum largely influences the mics of sulphonamides and certain other antimicrobials. in testing susceptibility of anaerobes to doxycycline, the mics determined by a ...	1978	365718
ribosomal proteins l7/l12 localized at a single region of the large subunit by immune electron microscopy.		1978	368343
a reliable test for differentiation and presumptive identification of certain clinically significant anaerobes.	a modification of the slide catalase test was evaluated to determine its reliability for the presumptive identification of certain anaerobic gram-negative and gram-positive organisms isolated from clinical specimens. a total of 650 fresh isolates was evaluated. growth from a trypticase blood agar plate or schaedler's agar with laked blood was transferred to a slide and a drop of 15% h2o2 with tween 80 added. veillonella alcalescens, proprionibacterium species, peptococcus species, and bacteroide ...	1978	339709
qualitative study of paradoxical zone phenomenon of penicillins against 17 bacterial species of clinical importance.	using a triple agar layer technique and enzymatic inactivation of penicillin, the occurrence of a paradoxical zone phenomenon (illustrated by a typical 'target' image around the reservoir of antibiotic) was determined for several bacterial species specially chosen with regards to their taxonomic position, clinical importance and penicillin susceptibility. among gram-positive bacteria, a paradoxical zone was obtained for approximately 43% of the strains studied here (all 10 strains of staphylococ ...	1978	340171
bacterial flora of the small bowel before and after bypass procedure for morbid obesity.	the contents of the proximal jejunum and distal ileum were cultured quantitatively in eight patients who were undergoing intestinal bypass procedure for obesity. five jejunal specimens were sterile, and three contained low counts of a predominantly aerobic flora. ileal contents yielded variable but usually higher counts than in the jejunum, and there were similar numbers of anaerobes and aerobes. in three patients in whom a bypass was established, contents of the functioning small bowel showed c ...	1978	342634
a rapid slide test for penicillinase.	the authors developed a rapid slide test modification of the iodometric method for detection of penicillinase produced by organisms growing on routine plating media. a loopful of colonies is scraped from the agar surface and emulsified in one drop of an iodine-penicillin solution on a glass slide. addition of a drop of 0.4% starch solution results in a purple color when penicillinase is not present; a colorless reaction denotes a positive test. the slide test yielded positive results identical t ...	1978	345799
hematogenous bacteroides fragilis and proteus mirabilis infection in a dog with lymphocytic lymphoma of the spleen.		1978	346544
[bacteroides fragilis and its role in infections].		1978	347417
performance of converted pressure cookers and two conventional jars for anaerobic bacterial culture.	the simple conversion of commercial pressure cookers into inexpensive anaerobic jars is described. these containers were shown to be as good as the small conventional bbl polycarbonate gaspak and large vented 150 gas-replacement jars when assessed by means of three biological indicators: pseudomonas aeruginosa, bacteroides melaninogenicus, and bacteroides fragilis. ps. aeruginosa seeded on simmond's citrate agar was shown to be the most sensitive indicator of the three for traces of oxygen.	1978	348726
counts on viable bacteroides fragilis: a modification of the microdroplet technique.	a modification of sharpe's microdroplet counting technique is presented which permits viable counting of bacteroides fragilis. lysed horse blood was added to 0.1 soy digest agar droplets and 2% was found to be the optimal concentration which combined adequate intradroplet colony size with acceptable visibility on the counting screen of the colworth droplette machine.	1978	349074
differences between cephalothin and newer parenterally absorbed cephalosporins in vitro: a justification for separate disks.	the activities of cefamandole and cefoxitin in vitro were compared with that of cephalothin against staphylococci and gram-negative bacilli. cephalothin was the most active agent against staphylococci. cefamandole exhibited the greatest activity against the enterobacteriaceae, with the exceptions of serratia marcescens and indole-positive proteeae, against which cefoxitin was the most active antibiotic. the activity of newer cephalosporins that are resistant to the beta-lactamases of gram-negati ...	1978	349096
a comparative study of the activity of cefamandole and other cephalosporins and analysis of the beta-lactamase stability and synergy of cefamandole with aminoglycosides.	the antibacterial activity of cefamandole against 445 clinical isolates was investigated and compared with the activity of other known cephalosporins (cephalothin, cephaloridine, cephalexin, and cefazolin) and of two penicillins (ampicillin and carbenicillin). cefamandole was the most active antibiotic against isolates of citrobacter, enterobacter, and shigella, and its activity against staphylococcus aureus, bacteroides, and some members of the enterobacteriaceae was comparable to that of the o ...	1978	349097
management and microbiology of cutaneous abscesses.	cutaneous abscesses in the perineal region contain primarily anaerobes commonly found in stool. non-perineal abscesses contain mixed microflora indigenous to the skin. bacteroides fragilis, the only anaerobe resistant to penicillin, is found predominantly in the perineal area. staphylococcus aureus, although the most common aerobe found, is seen less frequently than expected and is almost always resistant to penicillin. escherichia coli and neisseria gonorrhoeae are rarely found. incision and dr ...	1978	349218
anaerobic septicemia after transrectal prostatic biopsy.	transrectal biopsy of the prostate resulted in anaerobic septicemia in two patients, despite parenteral gentamicin sulfate prophylaxis. bacteroides fragilis sepsis developed subacutely in one patient having a postbiopsy pelvic abscess. clostridium perfringens sepsis occurred fulminantly in another patient 24 hours after biopsy of a gland extensively involved with adenocarcinoma. these cases indicate a potential hazard of sepsis due to anaerobic contamination with rectal microflora at the time of ...	1978	204264
ovarian involvement by cytomegalovirus.		1978	204571
necrotizing pancreatitis due to simian adenovirus type 31 in a rhesus monkey.	simian adenovirus type 31 was isolated from pancreatic tissue of an 8-year-old male rhesus monkey that died as the result of acute necrotizing pancreatitis. histologically, the pancreas showed wide-spread necrosis, extensive infiltration of polymorphonuclear leukocytes, and nuclear inclusions in pancreatic acinar cells. large numbers of adenovirus particles were demonstrable in the acinar cells by electron microscopy. this is the second case of adenovirus-associated pancreatitis we have found in ...	1978	205187
characterization and sequence analysis of a recombination site in the hybrid virus ad2+nd.		1978	205651
the frequencies of transcription from the e- and l-strands of polyoma dna.	exhaustion type hybridization was used to measure the amount of nuclear virus rna complementary to the early (e) and late (l) polyoma virus dna strands. at 36 h after infection between 2.5 and 7.3% of the newly synthesized virus rna was complementary to the e-strand (-strand) and between 92.7 and 97.5% was complementary to the l-strand (+strand). this proportion was independent of the labelling time, indicating similar accumulation of the e- and l-rna transcripts in the nucleus. the nuclear e- a ...	1978	206660
bone infections involving anaerobic bacteria.	over 700 cases of anaerobic osteomyelitis have been reported in the literature. nonetheless, most reviews of osteomyelitis have paid little attention to the potential role of anaerobes in bone infections. there have, as yet, been no prospective studies of osteomyelitis utlizing optimal anaerobic transport and culture techniques. in a retrospective study of osteomyelitis at wadsworth va hospital from 1973--1975, 39 percent of 58 patients with osteomyelitis had an infection involving anaerobes. an ...	1978	207946
[effect of actinomycin d and daunomycin on the biosynthesis of nucleic acids in cells transformed by oncornavirus and on the biosynthesis of viral nucleic acids (author's transl)].		1978	208136
[immunofluorescence with the pi-3 virus--study of various working conditions for the detection of viral infection using immunofluorescence on various types of cell cultures].	we used the fluorescence method for the investigation of the sensitivity of several kinds of cell cultures to the infection with the parainfluenza virus 3 (pi-3). cultures from calf kidneys were the most sensitive while we did not determine any differences between primary cultures and cultures of the first and second subpassages and/or freshly cultivated or incubated cultures over seven days at a temperature of 37 degrees c. equal values of infection titres like on the cultures of calf kidneys w ...	1978	208220
effect of zinc and other chemical agents on foot-and-mouth-disease virus replication.	chemical agents reported to inhibit the growth of various ribonucleic acid and deoxyribonucleic acid viruses were tested against foot-and-mouth disease virus in cell culture. these included zn(2+), aurintricarboxylic acid, polyribocytidylic acid, polyriboinosinic acid, phosphonoacetic acid, and the viral contact inactivator n-methyl isatin beta-thiosemicarbazone alone and with cuso(4). the most effective agent, zn(2+), inhibited foot-and-mouth disease virus production in primary calf kidney cell ...	1978	208461
[in vitro activity of ornidazole against anaerobic organisms. differences seen in certain strains in relation to the partial pressure of oxygen. (author's transl)].		1978	209402
the clinical importance of anaerobic bacteria in wound infections after gastrointestinal surgery.	wound cultures from 54 patients with infections after gastrointestinal surgery were examined. cultures from wounds after surgery on the upper gastrointestinal tract grew few organisms, mainly aerobic gram-positive cocci. culture from wounds on the lower gastrointestinal tract grew strains of bacteria, aerobic and anaerobic gram-negative rods dominating. indirect immunofluorescence studies on acute and convalescent phase sera showed significant immune response against bacteroides fragilis in a ma ...	1978	209532
humoral antibodies to mouse mammary tumor virus in sera from breast cancer patients.		1978	220186
[synergistic effect of ampicillin and dicloxacillin against bacteroides fragilis (author's transl)].		1978	246041
cefuroxime, a beta-lactamase-resistant cephalosporin with a broad spectrum of gram-positive and -negative activity.	the in vitro activity of cefuroxime, a cephalosporin antibiotic, was investigated against 604 isolates and compared with the activity of other beta-lactam compounds. cefuroxime had activity comparable to that of other cephalosporins, including cefamandole and cefoxitin, against streptococcal and staphylococcal species; most streptococci were inhibited by 0.1 mug or less per ml, and staphylococci were inhibited by 1.6 mug or less per ml. enterococci were relatively resistant. cefuroxime inhibited ...	1978	248268
infective endocarditis: part ii. current therapy.		1978	249230
carbenicillin for treatment of bacteroides fragilis infections: why not penicillin g?	carbenicillin has been advocated for treatment of infections caused by bacteroides fragilis and other anaerobic bacteria. wide-scale use of the drug in this setting could result in a substantial increase in carbenicillin-resistant pseudomonas aeruginosa, an effect that would have serious implications. thirty-four strains of b. fragilis, one-half from bacteremic infections, were tested in vitro, and penicillin g was found to be twice as active as carbenicillin on an equal weight basis; 94% of the ...	1978	253006
tetracyclines in gynecologic infections.	the use of tetracyclines in salpingitis and in postsurgical gynecological infections is outlined. unless the patient is allergic, the drug of choice in gonococcal salpingitis is penicillin or a derivative. however, a study of outpatients with gonococcal salpingitis showed that a majority of 197 women studied became asymptomatic 5 days after starting tetracycline treatment. in nongonococcal acute salpingitis, evidence is good that both aerobic and anaerobic organisms are usually involved, espe ...	1978	272213
effect of hypophysectomy on dentin production in maxillary incisors in the rat.		1978	274803
[report on the capsule dosage and mixing system. 3. suitability testing from a technological and clinical point of view].	the results from experiments with composite filling materials, silicate cements, stone cements, polyacrylate cements, eba cements and amalgam testify to the suitability of a mixing apparatus already presented (cf. par ii). apart from industrial predosed products, well known multicomponent materials prepared until now manually, among which evicrol, were mixed mechanically.	1978	274850
the ultrastructure of human osteosarcoma: a study of nine cases.	electron microscopic study of 9 osteosarcomas corroborates the light microscopic observation that cells with osteoblastic, chondroblastic and fibroblastic features occur in osteosarcomas. two types of multinucleated giant cells were observed, one was osteoclast-like. the other had anaplastic and degenerative changes. the intercellular matrix is composed of collagen fibers, amorphous ground substance with osteoid and tumor bone. contrary to many previous electron microscopic reports, osteosarcoma ...	1978	275014
the effect of indomethacin on cardiovascular and lysosomal mechanisms during experimental myocardial ischemia.	the present study evaluated the effects of indomethacin (indo) on cardiovascular and lysosomal mechanisms during experimental myocardial ischemia (mi). indo (5 mg/kg) was infused iv prior to mi, and the results were compared to vehicle-treated and sham-operated dogs. indo induced a slight hypertension after mi. additionally, indo attenuated the decline in coronary blood flow in the non-ischemic myocardium after mi. myocardial lysosomes (biopsied three hours post-mi) were more labile in ischemic ...	1978	262078
the effect of arachidonic acid on the response of the isolated liver to hypoxia.	arachidonic acid, the precursor molecule of the bisenoic series of prostaglandins, was investigated for its ability to modify the response of isolated perfused livers to hypoxia. rabbit livers were perfused at a constant rate of flow with krebs-henseleit bicarbonate buffer for two hours following the initiation of severely hypoxic conditions. this procedure resulted in significant increases in the wet weight of the liver, and also resulted in the release of intracellular enzymes into the perfusi ...	1978	262082
effects of isolation in male and female rats: shock-elicited behaviour, pellets, water and saline intake, plasma and brain biochemistry and organ weights.		1978	284564
[acute dental care in stockholm municipality].		1978	284615
bilateral reticular formation lesions causing coma: their effects on regional cerebral blood flow, glucose utilization and oxidative metabolism.		1978	284730
decrease of rat liver cysteine dioxygenase (cysteine oxidase) activity mediated by glucagon.	the hepatic cysteine dioxygenase activity of rats was markedly decreased by the intraperitoneal administration of glucagon. the enzyme activity was also decreased by either dibutyryl cyclic amp or theophylline. the prior administration of actinomycin d completely blocked the glucagon-mediated decrease of enzyme activity, while administrations of this inhibitor of protein synthesis after glucagon injection did not block the decrease of enzyme activity. a single administration of actinomycin d res ...	1978	212416
the synthesis of complex-type oligosaccharides. i. structure of the lipid-linked oligosaccharide precursor of the complex-type oligosaccharides of the vesicular stomatitis virus g protein.	the synthesis of the complex-type oligosaccharide unit of the vesicular stomatitis virus g protein is initiated by the en bloc transfer of a high molecular weight oligosaccharide from a lipid carrier to the nascent polypeptide. following transfer the oligosaccharide is "processed" by removal of glucose and mannose residues and the sugars that constitute the outer branches of the complex-type oligosaccharide are added. the structure of the oligosaccharide moiety of the lipid-linked precursor has ...	1978	212434
suppression of interferon production in mouse spleen cells by cytochalasin d.	cytochalasin d is thought to impair microfilament function. the present study has investigated its effects on four different systems in which interferon is formed, namely (1) mouse fibroblasts induced with virus (2) mouse spleen cells induced with virus, or (3) with endotoxin or (4) by allogeneic stimulation. cytochalasin d did not suppress formation of interferon by fibroblasts (l cells) or spleen cells stimulated with either hvj or ndv. however it did suppress production of interferon by splee ...	1978	212512
incomplete anaerobiosis as a cause of metronidazole 'resistance'.	clostridium welchii, used as a control, was found to grow well in a microaerophilic jar used for campylobacters but appeared resistant to a metronidazole disc although the campylobacter was sensitive. minimum inhibitory concentrations for six strains of cl. welchii were up to 64-fold higher in these conditions than when grown anaerobically. zones of inhibition with both cl. welchii and bacteroides fragilis varied with the amount of air admitted to anaerobic jars.	1978	213449
studies on secretory glycoproteins in the rat exocrine pancreas. iii. intracellular transport of fucose-labeled proteins as studied by cell fractionation.	the transcellular movement of fucosylated glycoproteins has been studied in vitro using rat pancreatic lobules and cell fractionation procedures, and has been compared with the well established pathway of secretory proteins. using tritiated leucine as pulse label for the latter, their translocation from the rough endoplasmatic reticulum into the golgi complex and finally into zymogen granules could be followed. in the case of glycoproteins, 14c-fucose was incorporated mainly into the smooth micr ...	1978	214234
linkage of the endogenous avian leukosis virus genome of virus-producing chicken cells to inhibitory cellular dna sequences.	the endogenous avian leukosis virus genome of uninfected virus-producing(v+) chicken embryo fibroblasts appears to be inefficiently transcribed and is noninfectious in transfection assays of high molecular weight dna. we previously proposed that the endogenous virus genome was linked to a cis-acting control element which inhibited its transcription and, consequently, interfered with transfection by endogenous viral dna. we now report that dna of uninfected v+ cells is infectious at a low level w ...	1978	214243
a fatal enteric syndrome in mystromys albicaudatus (white tailed rat) following topical antibiotic treatment.	heavy death losses (59%) occurred in adult mystromys 3--14 days after muscle biopsies were taken from their rear legs. clinical signs included anorexia, depression, and rough hair coat. predominant necropsy findings were hrmorrhagic typhlitis and colitis. results of studies evaluating the roles of the anesthetic and the tropical antibiotic ointment suggested that the deaths were caused by ingestion of the topically applied antibiotic.	1978	214636
isolation and partial characterization of secreted mouse pituitary prolactin.	prolactin secreted by mouse anterior pituitaries was purified by gel filtration on sephadex g-100. electrophoretic homogeneity of the purified hormone was demonstrated in several gel systems, and electrophoresis in the presence of sodium dodecyl sulfate indicated an apparent molecular weight of 21 000 +/- 2000. mouse and ovine prolactin displayed parallel dose vs. response curves in radio-receptor binding studies, indicating that these two hormones compete for identical receptor sites on rabbit ...	1978	215218
[detection of tubercular infection after bcg vaccination].	the author has followed several groups of children over a period of many years and evidenced the general decrease of the level of tuberculin reactivity. the implications are discussed, of the b.c.g. vaccination on the tuberculous allergy and the possibility to differentiate post-vaccinal allergy with the aid of skin testing, using 2 and 10 ppd units. the importance is stressed, of the vaccinal scar as an indication of a good immune reactivity, and thus of protection against contamination with vi ...	1978	217060
influence of early anosmia on the developing olfactory bulb.		1978	218250
tonsillectomy and infectious mononucleosis.	tonsillar tissue may be the primary site of infection with epstein-barr virus (ebv), the etiologic agent of classical infectious mononucleosis (im). therefore, a retrospective study of the association between tonsillectomy and im was performed in a college student population. in the first part of the study, tonsillectomy rates were compared between 164 im-positive students and 164 student controls who attended ucla in 1972-1975. although it was determined that the development of im during colleg ...	1978	203187
pyrimidine nucleoside monophosphate kinase from human leukemic blast cells.		1978	203385
detection of alcohols and volatile fatty acids by head-space gas chromatography in identification of anaerobic bacteria.	a head-space gas chromatographic technique for the analysis of volatile bacterial metabolites is described. bacteroides fragilis, clostridium perfringens, and propionibacterium acnes, cultured in a glucose-containing peptone yeast extract medium, were studied. the head-space technique was compared with the injection of the complete liquid culture medium, and solvent extracts thereof, into the gas chromatograph. volatile fatty acids could be detected by all three methods, whereas alcohols produce ...	1978	203602
piperacillin, a new penicillin active against many bacteria resistant to other penicillins.	the in vitro activity of piperacillin, a new semisynthetic piperazine penicillin derivative, was evaluated against 626 clinical isolates and compared with the activity of other beta-lactam antibiotics. at a concentration of 0.1 microgram/ml, piperacillin inhibited all streptococci except enterococci. non-beta-lactamase-producing staphylococci were inhibited by 1.6 microgram or less per ml. both beta-lactamase- and non-beta-lactamase-producing haemophilus were inhibited by 0.1 microgram/ml. piper ...	1978	122519
in vitro study of clavulanic acid in combination with penicillin, amoxycillin, and carbenicillin.	the activity of clavulanic acid alone and in combination with penicillin, amoxycillin, and carbenicillin was studied. marked reductions in the minimum inhibitory concentrations (mics) for a wide spectrum of beta-lactamase-producing clinical isolates were found. of particular interest were the decreased mics of penicillin for bacteroides fragilis and beta-lactamase-producing strains of neisseria gonorrhoea in the presence of the clavulanic acid. beta-lactamase-producing strains of escherichia col ...	1978	122520
the effect of treatment with a polychlorinated-biphenyl mixture on hepatic and extrahepatic xenobiotic metabolism in the rat and ferret [proceedings].		1978	105952
thyroxine inactivation by starvation in cultured hepatocarcinoma cells, formation of reverse triiodothyronine.	the effect of starvation on thyroid hormone metabolism was studied in monkey hepatocarcinoma monolayer cultures. nonphenolic ring monodeiodination of thyroxine, 3, 5, 3'-triiodothyronine and 3, 3'-diiodothyronine was accelerated. since phenolic ring deiodination of 3, 3',5'-triiodothyronine (reverse t3) was unaffected, this metabolite accumulated in the medium during thyroxine metabolism. this suggests that increased serum reverse t3 in malnourished humans may be caused by enhanced deiodination ...	1978	105981
anti-kappa/lambda immunobead for detection of human b lymphocytes.	several methods were compared for quantitating the b lymphocytes in human peripheral blood. rbc rosette assays including sheep and bovine red blood cells, and immunobead rosette assays including beads coated with anti-kappalambda and trivalent anti-gam antibodies respectively were investigated. the anti-kappalambda bead assay proved to be simpler, faster, higher in reproducibility, and appeared to be more accurate than any of the other assays.	1978	105987