Publications

identification and characterization of is2404 and is2606: two distinct repeated sequences for detection of mycobacterium ulcerans by pcr.	molecular analysis of mycobacterium ulcerans has revealed two new insertion sequences (iss), is2404 and is2606. is2404 was identified by complete sequencing of a previously described repetitive dna segment from m. ulcerans. this element is 1,274 bp long, contains 12-bp inverted repeats and a single open reading frame (orf) potentially encoding a protein of 327 amino acids (aa), and apparently generates 7-bp direct repeats upon transposition. amino acid similarity was found between the putative t ...	1999	10074520
effects of changes in membrane sodium flux on virulence gene expression in vibrio cholerae.	the expression of several virulence factors of vibrio cholerae is coordinately regulated by the toxt molecule and the membrane proteins tcpp/h and toxr/s, which are required for toxt transcription. to identify proteins that negatively affect toxt transcription, we screened transposon mutants of v. cholerae carrying a chromosomally integrated toxt::lacz reporter construct for darker blue colonies on media containing 5-bromo-4-chlor-3-indolyl beta-d galactoside (x-gal). two mutants had transposon ...	1999	10077658
a new level in the vibrio cholerae toxr virulence cascade: apha is required for transcriptional activation of the tcpph operon.	the expression of the toxr virulence regulon is dependent upon the regulatory proteins toxr/toxs, tcpp/tcph and toxt. we describe here a previously unidentified gene in vibrio cholerae, apha (activator of tcpp and tcph expression), which is required for the transcription of the tcpph operon. under conditions normally optimal for virulence gene expression, an in frame apha deletion decreased the expression of a cholera toxin promoter fusion (ctx-lacz) and prevented the production of the toxin co- ...	1999	10048021
antibiotic resistance conferred by a conjugative plasmid and a class i integron in vibrio cholerae o1 el tor strains isolated in albania and italy.	multidrug-resistant vibrio cholerae o1 el tor strains isolated during the 1994 outbreak of cholera in albania and italy were characterized for the molecular basis of antibiotic resistance. all strains were found to be resistant to tetracycline, streptomycin, spectinomycin, trimethoprim, sulfathiazole, and the vibriostatic compound o/129 (2,4-diamino-6,7-diisopropylteridine). resistance genes were self-transferable by a conjugative plasmid of about 60 mda, with the exception of spectinomycin resi ...	1999	10049292
environmental signals modulate toxt-dependent virulence factor expression in vibrio cholerae.	the regulatory protein toxt directly activates the transcription of virulence factors in vibrio cholerae, including cholera toxin (ct) and the toxin-coregulated pilus (tcp). specific environmental signals stimulate virulence factor expression by inducing the transcription of toxt. we demonstrate that transcriptional activation by the toxt protein is also modulated by environmental signals. toxt expressed from an inducible promoter activated high-level expression of ct and tcp in v. cholerae at 3 ...	1999	10049382
role of surface proteins in vibrio cholerae attachment to chitin.	the role of surface proteins in vibrio cholerae attachment to chitin particles in vitro was studied. treatment of v. cholerae o1 atcc 14034 and atcc 14035 with pronase e reduced the attachment of bacteria to chitin particles by 57 to 77%. a statistically significant reduction was also observed when the attachment to chitin was evaluated in the presence of homologous sarkosyl-insoluble membrane proteins (mps) (67 to 84%), n-acetylglucosamine (glcnac) (62%), the sugar that makes up chitin, and whe ...	1999	10049907
the mutk gene of vibrio cholerae: a new gene involved in dna mismatch repair.	a new gene, mutk, of vibrio cholerae, encoding a 19-kda protein which is involved in repairing mismatches in dna via a presumably methyl-independent pathway, has been identified. the product of the mutk gene cloned in either high- or low-copy-number vectors can reduce the spontaneous mutation frequency of escherichia coli muts, mutl, mutu, and dam mutants. the spontaneous mutation frequency of a chromosomal mutk knockout mutant was almost identical to that of wild-type v. cholerae cells, indicat ...	1999	9922251
the spi-3 pathogenicity island of salmonella enterica.	pathogenicity islands are chromosomal clusters of pathogen-specific virulence genes often found at trna loci. we have determined the molecular genetic structure of spi-3, a 17-kb pathogenicity island located at the selc trna locus of salmonella enterica serovar typhimurium. the g+c content of spi-3 (47.5%) differs from that of the salmonella genome (52%), consistent with the notion that these sequences have been horizontally acquired. spi-3 harbors 10 open reading frames organized in six transcr ...	1999	9922266
structure-based discovery of a pore-binding ligand: towards assembly inhibitors for cholera and related ab5 toxins.	cholera toxin (ct) and escherichia coli heat-labile enterotoxin (lt) are two closely related multi-subunit ab5 proteins responsible for significant morbidity and mortality worldwide. an attractive strategy to prevent disease by these organisms is to interfere with the assembly process of these toxins, since prevention of toxin formation is better than preventing the effects of a toxin which is already formed. the b subunits form a ring with a central pore which surrounds the c-terminal residues ...	1999	9887271
two forms of vibrio cholerae o1 el tor hemolysin derived from identical precursor protein.	vibrio cholerae o1 grown in heart infusion broth produces two forms of el tor hemolysin (eth) monomers of 65 and 50 kda. these monomers form several different sizes of mixed oligomers ranging from 180 to 280 kda in the liposomal membranes. we found that the n-terminal amino acid sequences, nh2-trp-pro-ala-pro-ala-asn-ser-glu, of both the 65- and 50-kda toxins were identical. we assumed, therefore, that the 65- and 50-kda toxins were derivatives of the identical precursor protein and the 50-kda p ...	1999	9889386
microbial-host interactions at mucosal sites. host response to pathogenic bacteria at mucosal sites.		1999	9893360
bacterial mucosal vaccines: vibrio cholerae as a live attenuated vaccine/vector paradigm.		1999	9893363
preliminary assessment of the safety and immunogenicity of a new ctxphi-negative, hemagglutinin/protease-defective el tor strain as a cholera vaccine candidate.	vibrio cholerae 638 (el tor, ogawa), a new ctxphi-negative hemagglutinin/protease-defective strain that is a cholera vaccine candidate, was examined for safety and immunogenicity in healthy adult volunteers. in a double-blind placebo-controlled study, no significant adverse reactions were observed in volunteers ingesting strain 638. four volunteers of 42 who ingested strain 638 and 1 of 14 who received placebo experienced loose stools. the strain strongly colonized the human small bowel, as evid ...	1999	9916056
isolation and characterization of rugose form of vibrio cholerae o139 strain mo10.	an extracellular exopolysaccharide (slime) is produced by vibrio cholerae o139 mo10 in response to nutrient starvation. the presence of this slime layer on the cell surface and its subsequent release have been shown to be associated with biofilm formation and the change from a normal smooth colony morphology to a rugose one. an immunoelectron microscopic examination demonstrated that there is an epitope common to the exopolysaccharide antigen of v. cholerae o1 and that of o139 mo10.	1999	9916115
rfb mutations in vibrio cholerae do not affect surface production of toxin-coregulated pili but still inhibit intestinal colonization.	the toxin-coregulated pilus (tcp) of vibrio cholerae is essential for colonization. it was recently reported that rfb mutations in v. cholerae 569b cause the translocation arrest of the structural subunit of tcp, raising the possibility that the colonization defects of lipopolysaccharide mutants are due to effects on tcp biogenesis. however, an rfbb gene disruption in either v. cholerae o395 or 569b has no apparent effect on surface tcp production as assessed by immunoelectron microscopy and ctx ...	1999	9916119
quantification of bacterial lipopolysaccharides by the purpald assay: measuring formaldehyde generated from 2-keto-3-deoxyoctonate and heptose at the inner core by periodate oxidation.	we have adapted the purpald assay (m. s. quesenberry and y. c. lee, anal. biochem. 234, 50-55, 1996) to quantify lipopolysaccharide (lps) content in solution in 96-well microtiter plates at room temperature. this method employs the oxidation of unsubstituted terminal vicinal glycol groups in 2-keto-3-deoxyoctonate (kdo) and l-(or d-)glycero-d-manno-heptose of lps molecules by periodate to release formaldehyde. the formaldehyde is quantified at 550 nm (or 530-570 nm) by reacting with purpald reag ...	1999	9918668
purification and characterization of an aeromonas caviae metalloprotease that is related to the vibrio cholerae hemagglutinin/protease.	a zinc metalloprotease (ap34) from aeromonas caviae was purified by ammonium sulfate precipitation and subsequent gel filtration through sephadex g-100 and sephadex g-50 superfine. the molecular mass was estimated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis to be 34 kda. the protease showed maximum activity at ph 7.0 and was stable at 60 degrees c. ap34 was completely inactivated by edta and zincov. the n-terminal amino acid sequence of ap34 showed a high degree of homology with ...	1999	9919673
response of wild-type mutants of vibrio cholerae o1 possessing different combinations of virulence genes in the ligated rabbit ileal loop and in ussing chambers: evidence for the presence of additional secretogen.	five wild-type mutant strains of vibrio cholerae serogroup o1 that lacked the ctx virulence cassette, or contained a natural deletion of a virulence gene within the ctx virulence cassette, or possessed an additional virulence gene, along with a prototype toxigenic strain representing the el tor classical biotypes were examined by in-vivo and in-vitro methods to determine their enterotoxic potential. the ability of whole cells and culture supernates of the strains to cause fluid accumulation in t ...	1999	9920125
characterisation of cholera toxin by liquid chromatography--electrospray mass spectrometry.	cholera toxin, one of the toxins that may be generated by various strains of the bacterium vibrio cholerae, can be considered as a substance possibly used in biological warfare. the possibilities of characterising the toxin by liquid chromatography electrospray mass spectrometry (lc-es-ms) were investigated. the toxin can be detected by flow-injection (fia) es-ms of a dialysed solution and observation of the charge envelope signals of its a-unit and b-chain protein; sufficient information for id ...	1999	9920483
oligomerization of vibrio cholerae cytolysin yields a pentameric pore and has a dual specificity for cholesterol and sphingolipids in the target membrane.	vibrio cholerae cytolysin permeabilizes animal cell membranes. upon binding to the target lipid bilayer, the protein assembles into homo-oligomeric pores of an as yet unknown stoichiometry. pore formation has been observed with model liposomes consisting of phosphatidylcholine and cholesterol, but the latter were much less susceptible to the cytolysin than were erythrocytes or intestinal epithelial cells. we here show that liposome permeabilization is strongly promoted if cholesterol is combined ...	1999	9880509
a simple, nonenzymatic method for desialylating polysialylated ganglio-n-tetraose series gangliosides to produce gm1.	dowex-50w-h+ was used to catalyze the highly selective desialylation of polysialylated ganglio-n-tetraose series gangliosides to yield primarily gm1. high performance thin-layer chromatographic analysis of recovered lipid indicated that 60-70% of the recovered ganglioside was gm1. identification of the major product as gm1 was confirmed by proton nmr spectra and lack of sialic acid release by vibrio cholerae sialidase.	1999	9869662
resurgent vibrio cholerae o139: rearrangement of cholera toxin genetic elements and amplification of rrn operon.	the unprecedented genesis of a novel non-o1 vibrio cholerae strain belonging to serogroup o139, which caused an epidemic in late 1992 in the indian subcontinent, and its subsequent displacement by el tor o1 vibrios after 18 months initiated a renewed investigation of the aspects of the organism that are related to pathogenesis. the reappearance of v. cholerae o139 with altered antibiotic sensitivity compared to o139 bengal (o139b) in late 1996 has complicated the epidemiological scenario of v. c ...	1999	9864209
[improvement in the prognosis of rapid progressive glomerulonephritis by plasmapheresis treatment].		1999	2860543
palliative embolization of arterial renal tumour supply. results in 10 cases.	palliative occlusion of the arterial renal tumour supply was performed in 10 patients and the follow up is reported. nine of the patients had no subsequent nephrectomy. spongostan (99% gelatin) was used as the embolic material in 4 patients with the addition of steel coils in 2. bucrylate was used in 6 cases. six patients are alive with survival rates presently ranging from 3 to 24 months after embolization. improvement of the survival time cannot be estimated but local symptoms such as hematuri ...	1999	91307
[cerebrospinal fluid monoamine metabolites and cyclic nucleotides in the patients with epilepsy (author's transl)].		1999	93481
determination of the quaternary structure of alpha-d-mannosidase from medicago sativa l. [proceedings].		1999	93904
bacterial infections of the small intestine and colon.	enterotoxigenic escherichia coli, vibrio cholerae o1, campylobacter jejuni, salmonella species, and shigella species are major causes of morbidity and death in diarrheal disease. more recently recognized pathogens are v. cholerae o139 and enterohemorrhagic e. coli. in addition to this, several presumptive virulence factors have been identified in diarrheagenic e. coli and in other species. to confirm these as virulence factors we need good diagnostic tools and good epidemiological studies. these ...	1999	17023917
rising health care costs: a schism between medicine and business?		1999	97049
suction drainage after stripping of long saphenous veins.		1999	89589
the use of relaxation and desensitisation techniques in eliminating a sleep problem.	this study describes the treatment of a 16-year-old youth unable to sleep, failing to respond to sleeping pills, who on a programme of relaxation and desensitisation in six weeks was able to control his sleeping patterns. on followup four months, six months and twelve months later this ability had been maintained.	1999	24192
[microspectrophotometric study of biogenic amines in ganglions of the central nervous system of crepidula fornicata (phil.)].	the fluorescent products formed from biogenic amines treated with formaldehyde according to the method of falck and owman have been studied in the brain of crepidula fornicata. the microspectrophotometric analysis of cellular indolamines shows excitation emission maxima at 385--525 nm (serotonine) and catecholamine at 410--475 nm upon hcl treatment catecholamine products show a shift of the excitation peak from 410 to 370 nm (dopamine).	1999	103642
diminished cellular immunity due to impaired nutrition in oesophageal carcinoma.	the nutritional status of 15 negro patients suffering from unresectable carcinoma of the midthoracic oesophagus was evaluated before and after palliative pulsion intubation. all were shown to be in negative nitrogen balance and to have a compromised non-specific cellular immune response. correction of protein-calorie malnutrition and the achievement of positive nitrogen balance were associated with an increase in absolute lymphocyte and t lymphocyte numbers and a significant increase in lymphocy ...	1999	96903
[proton beam treatment in the neurosurgical field].		1999	96847
simultaneous treatment of toxic diffuse goiter with i-131 and antithyroid drugs: a prospective study.	we report a prospective study to avaluate the effect of antithyroid drugs containing the sulfhydryl radical on the outcome of i-131 (rai) therapy. twenty-four male patients withe toxic diffuse goiter were assigned randomly into tow treatment groups: group a received rai treatment while on antighyroid drugs after attainment of euthyroidism; group b received no antithyroid drugs before, or when, rai was given. patients in each group received a dose of rai calculated to deliver approximately 5000 r ...	1999	94089
[monitoring the course of malignant neoplasms of the genital organs in women by means of determination of blood serum level of fucose, sialic acid, cea and afp].		1999	94024
the use of behavioral checklists to assess physical examination skills.		1999	17754
substrate specificity of hexosaminidase a isolated from the liver of a patient with a rare form (ab variant) of infantile gm2 gangliosidosis and control tissues.		1999	96668
acute acalculous cholecystitis: a complication of hyperalimentation.	in a 5 year period, eight patients in whom acute acalculous cholecystitis developed during intravenous hyperalimentation are reviewed with emphasis on factors contributing to pathogenesis. gallbladder distention, biliary stasis, and bile inspissation, thought to be important in the pathogenesis of this disease, are enhanced with the use of hyperalimentation, and this potential complication is being seen with increasing frequency in seriously ill or injured patients who are being fed parenterally ...	1999	116561
analysis of rna-binding proteins of cryptobiotic gastrula of artemia saline [proceedings].		1999	93910
relaxation of striated muscle by low concentrations of atp [proceedings].		1999	93891
role of nonspecific and specific suppressor factors in immunity.		1999	93866
retention of dr-specific memory in primed lymphocytes grown in pha-conditioned media.		1999	93819
ear-lobe crease.		1999	84982
[mechanism of antibiotic action].		1999	93768
[retinal neovascularization: topological, morphological and hemodynamic features (author's transl)].		1999	91317
catecholamines and hyperthyroidism.		1999	22414
haloperidol and lithium blocking of the mood response to intravenous methylphenidate.	the euthymic manic-d-pressive patients with therapeutic plasma lithium levels were each given two i.f. infusions of 30 mg of methylphenidate. the infusions were separated by at least 3 days. before one infusion each patient was given 5 mg of haloperidol i.v. and before the other infusion each was given an identical volume of saline. a psychiatric observer was blind to the nature of the pretreatment and the order of pretreatment was randomized. saline pretreated patients showed marked activation ...	1999	96473
[diagnosis of malignant neoplasms by studying the changes in the concentration of fetal hemoglobin, hemoglobin a2 and carbonic anhydrases b and c. an application of discriminating function].	this publication proposes the utilization of an analytical discriminatory method in the diagnosis of malignant neoplasia. the multiple variable technique of analysis is suggested employing the quantification of the hbf, hba2, acb and acc. this has already been demonstrated in a previous study which suffered from quantifiable variations important in neoplastic disease. the confidence of the procedure has been proven when applied to 198 known cases, having classified them adequately 94 per cent of ...	1999	96435
atrial repolarization: its role in st elevation.	in four patients, ectopic supraventricular rhythm (or beats) with cephalad anomalous atrial activation and, generally, a short pr, were always associated with an st elevation in the leads with a negative p wave. an inverted ta wave appears to be responsible for the st elevation.	1999	89183
hyperthyroidism in juvenile diabetes mellitus.	three cases of hyperthyroidism occurring in juvenile patients with diabetes mellitus are presented. the presence of hyperthyroidism should be suspected in patients with diabetes mellitus when goiters develop and when there is unexplained weight loss, tachycardia, tremors, unexplained increases in insulin requirement, or instability of the diabetes with a tendency toward development of ketosis and/or ketoacidosis.	1999	96415
progress report on an evaluation of speech therapy for aphasia.		1999	93486
the use of the voiscope in improving the speech of profoundly deaf children.		1999	93485
[availability of the measurement of plasma beta-thromboglobulin (beta-tg) for cerebrovascular diseases (author's transl)].		1999	93482
unmasking of fetal determinants on adult bone marrow cells.		1999	91109
a neuropathologic study of whipple's disease.	a patient with whipple's disease developed massive and irreversible cns involvement after a drug-induced intestinal remission. the multifocal brain lesions were apparent grossly with the heaviest concentration being noted in rhinencephalon, diencephalon, and mesencephalon. this patient exhibited progressive neurologic deterioration, although viable organisms could not be identified in the brain at autopsy. astrocytes, pericytes, and choroid plexus cells attempted to dispose of the organism, in a ...	1999	93389
retinol-binding protein in malnutrition.		1999	90984
[effect of bromocriptine on the "prolactin-like cell" of nectophrynoides occidentalis (amphibia, viviparous anura): optical and electronic microscopical studies].	bromocriptin has an effect on prolactin-like cells of nectophrynoïdes occidentalis. 16 days after delivery, these cells are fully active in normal animals. retention of secretory granules and myelinic formations have been observed in the prolactin-like cells of females treated by cb 154.	1999	97001
[effect on macrophages of acute stress induced in mice by local irradiation].	in examining the role of radiation in inducing immunosuppression in tumor-bearing mice it has been shown that the experimental acute stress inadvertently generated by the procedure is profoundly immunosuppressive. it would appear that monocytes under the influence of glucocorticoïds are sequestered in the spleen. this monocyte immobilisation leads to rapid suppression of local inflammatory reactions including delayed hypersensitivity. the increased number of marcrophages in the spleen is co-inci ...	1999	96964
[identification of b-, t- and "zero" lymphocytes by staining for acid phosphatase].		1999	94125
cryocrystalglobulinemia in hairy cell leukemia.	a patient with hairy cell leukemia (leukemic reticuloendotheliosis) was noted to have a spurious leukocytosis caused by a spontaneously crystallizing cryoglobulin. the cryoprotein was identified as igg lambda. an intracytoplasmic immunoglobulin demonstrable within the hairy cell was also igg lambda. the cryoglobulin spontaneously disappeared over a four day period. a reliable automated count on the coulter model s could be obtained by prewarming the blood specimen to 37 c.	1999	103614
responsibility of the physician in the preservation of life.		1999	88925
[the myocardiopathies of hereditary neuro-muscular diseases].	this joint work has studied the cardiomyopathies occurring in hereditary neuro-muscular disorders (270 cases). the duchenne type of disorder (74 cases) was responsible for asystole (4 cases), for cardiomegaly, and especially for abnormalities of the ecg (59 cases)--q waves and large r waves in v1 and v6. the cardiomyopathy was of the hypokinetic type, with histological evidence of degeneration of the myocardial fibres. dystrophia myotonica of steinart (23 cases) caused conductive disorders (17 c ...	1999	96758
pancreatic islet cytology of the himalayan toad, bufo himalayanus.		1999	94018
characterization of the in vitro reassembly of tubulin derived from stable strongylocentrotus purpuratus outer doublet microtubules.		1999	33707
cryotherapy for palliation in rectal carcinoma.		1999	91566
studies on phosphate-solubilizing bacteria in soil and rhizosphere of different plants. ii. selection of the most efficient phosphate-dissolvers and their morphological grouping.	two hundred colonies which showed positive reaction on the plates prepared for the phosphate-dissolving bacteria from control soil rhizosphere soils and rhizoplane samples of maize, peas, or cotton were isolated at random. fifty isolates were selected as the most efficient isolates according to their capability for increasing the amounts of available phosphorus in the media with corresponding decreases in ph values. the percentage of the most efficient isolates differed according to type of plan ...	1999	22210
effects of x-rays on the chloroplasts of acetabularia mediterranea [proceedings].		1999	93929
study of spectrin phosphorylation and polymerization in normal and spherocytic red blood-cells [proceedings].		1999	93915
phenylketonuria variants.		1999	85126
grandmother's poisoned well: report of a case of methemoglobinemia in an infant in oklahoma.		1999	4688467
neonatal back-transport. cost-effectiveness.	this study examines the cost-effectiveness of returning previously ill neonates to community hospitals after treatment in a tertiary center, a concept known as "back-transport." the authors compared the charges for medical care during convalescence of a group of back-transported infants (bt infants; n = 20) with a similar group of infants who remained in a tertiary center for convalescence (nt infants; n = 20). the total charges for convalescent care (inpatient plus transport charges) for 20 rep ...	1999	3918219
systematic multi-modal treatment of osteosarcoma, with special reference to the role of fast neutron radiotherapy.	sixty-one patients with osteosarcoma were treated. twenty-four of these patients were managed with our systematic multi-modal treatment. overall survival rate was markedly improved chiefly by intensive systemic chemotherapy with multiple drugs, especially adriamycin and high dose methotrexate. preoperative regional intra-arterial infusion of anti-tumor drugs and fast neutron radiotherapy were employed and it was suggested that fast neutron had a higher relative biological effectiveness and a gre ...	1999	115950
pattern reversal evoked cortical responses in normals. a study of different methods of stimulation and potential reproducibility.	using a commercially available television set for stimulation of 78 healthy subjects, the upper limit of normal for the latency of the major positive wave (p 100) of checkerboard pattern reversal evoked potentials is practically the same as that obtained by employing slide projector combined with a rotating mirror. potentials evoked by a small pattern, for purely foveal stimulation, were often difficult to evaluate exactly. fixation of a large pattern at the upper border of the stimulus field br ...	1999	93635
raised level of cholesterol esters in the brain of protein undernourished mice.		1999	104008
ultrasonographic demonstration of glaucomatous optic nerve excavation.		1999	103912
[therapy of class ii, division 1 malocclusion without extraction of premolars during the mixed dentition period].		1999	96393
spontaneous pneumothorax in labor: case report.		1999	96378
analysis of the yolk proteins in drosophila melanogaster. translation in a cell free system and peptide analysis.		1999	103753
[palliative chemotherapy with 5 fu and cpm in cancer of the prostate with bone metastases resistant to oestrogens. a clinical trial (author's transl)].	the efficacy of an association of cyclophosphamide (cpm) and 5-fluorouracil was studied in 15 patients with prostate cancer not responding to oestrogen therapy, and more particularly its effect on pain due to bone metastases. no objective improvement was noted with this association, but there was a definitite reduction in bone metastases pain in 5 of the patients, with an average remission time of 4 months. half of the patients had nausea and vomiting, but in spite of this digestive intolerance ...	1999	94108
monoclonal antibodies against defined determinants of acetylcholine receptor.		1999	91535
[evaluation of the restoration of micturition after transvesical adenomectomy of the prostate using a urodynamic flow measurement method].		1999	93823
the mesencephalic exterolateral posterior nucleus of the mormyrid fish bryenomyrus niger: efferent connections studied by the hrp method.		1999	91414
haemodilution and blood-flow.		1999	88643
modulatory effects of oestrogen on immunological responsiveness. ii. suppression of tumour-associated immunity in patients with prostatic cancer.	the effect of oestrogen (diethylstilboesterol diphosphate, des-p) on immunity to tumour-associated antigens in patients with prostatic cancer was evaluated by leucocyte adherence inhibition, a suggested in vitro correlate of cellular immunity. significant (p smaller than 0.05) suppression of immunity to malignant prostate was observed in thirty out of thirty-one patients following pre-incubation of their leucocytes with therapeutically significant levels of des-p. suppression of tumour-associate ...	1999	93529
applied teaching concepts of animated motion slides in otolaryngology.	motion is an essential part of otolaryngologic function, and an understanding of concepts of motion is critical in teaching otolaryngology. standard movie projection devices have intrinsic defects, such as considerable expense to make, complexity of operation, and a lack of flexibility. slide projection transparencies (2x2) offer instructional flexibility but could not be used to project motion until recently. using applications of gelatin films of images with polarizing light, we have been able ...	1999	91151
the relationship between intracellular and extracellular potassium in normal and malnourished subjects as studied in leukocytes.	leukocyte potassium has been measured in normal subjects and in malnourished children with and without edema both on admission and during recovery. in nonedematous malnourished children the potassium content was low (328 mmol/kg dry solids) and took 2-3 weeks of rehabilitation to return to normal (374 mmol/kg dry solids). leukocytes from edematous children had normal intracellular potassium values. however, 5 days on a maintenance diet reduced the intracellular potassium in the children with kwa ...	1999	99717
[surgical management of thoracic and thoraco-abdominal injuries].	from 1970 to 1974 407 patients with thoracic injuries have been treated by the authors in the 2nd surgical and thoracic surgical department of the "jános" hospital, budapest--out of them 190 patients were classified as severely injured. the material and the operative technique in isolated thoracal and combined thoracal-abdominal injuries are discussed. the importance of the operative stabilization of the thoracic wall is emphasized and fixation of the thoracic wall by means of pericostal sutures ...	1999	17790
captopril in a hyponatraemic hypertensive: need for caution in initiating therapy.		1999	85145
trh test in routine diagnosis and postoperative control of patients with primary thyroid diseases.		1999	96643
ct of the esophagus: i. normal appearance.	the thoracic esophagus is easily demonstrable throughout its entire length on thoracic computed tomography (ct). the soft tissue planes separating the esophagus from its adjacent mediastinal structures are normally distinct. blurring or distortion of these tissue interfaces is a reliable indicator of disease. the normal ct anatomy of the esophagus and mediastinal relationships are described. air in the esophagus is considered a normal finding.	1999	116493
[choroidal neovascularization in the photocoagulated retina with diabetic retinopahy--a light and electron microscopic study (author's transl)].		1999	93415
erythemal and pigmentary phototest reactions in polymorphic light eruptions.	the erythemal and pigmentary skin reactions in 110 patients with chronic polymorphic light eruptions (pmle) and in 154 control persons were investigated by phototesting with a medium pressure mercury lamp. recording the erythemal threshold (med) at 2-h intervals for up to 24 h after irradition disclosed no differences between pmle patients and controls. there was, however, a tendency for the erythemal reaction to subside more slowly in the pmle patients; this tendency reached a statistically ver ...	1999	94208
chemotherapy of hodgkin's disease.	during the past 10 to 15 years, there have been dramatic improvements in the prognosis of patients with advanced hodgkin's disease resulting from the development of combination chemotherapy. the long-term follow-up of patients with advanced disease treated with mopp indicates that 66 per cent of those achieving complete remissions have not relapsed and remain off therapy at five and 10 years follow-up. attempts to make additions, subtractions or modifications in the mopp regimen have not general ...	1999	91466
diffuse cutaneous mastocytosis: a report of neonatal onset.	a child developed diffuse cutaneous mastocytosis when 20 days old. his prognosis appears good, compared with other reports of similar neonatal onset.	1999	94218
[renewal of noradrenaline in different zones of the central nervous system of inbred mice strains and their recombinants].	a good correlation exists between the learning capacity and norepinephrine metabolism in the neocortex of c57 and balb inbred mice strains, as well as their f1 hybrids and seven recombinant inbred strains derived from their cross. the animals with a better learning performance are characterised by low levels of norepinephrine, as well as a slow metabolic rate of this neurotransmitter in the cortex. such a correlation has not been found to exist in the other cerebral regions studied.	1999	96976
group systems of serum proteins and erythrocyte enzymes in malignant lymphoma.	four group systems of serum proteins (hp, gc, gm, km) and five group systems of erythrocyte enzymes (ap, pgm1, gpt, ak, esd) were determined in 63 patients with malignant lymphoma. statistical analysis of the distribution of the above mentioned systems in patients and polish population samples did not reveal any significant differences, which points to the lack of any correlation between the disease and the group systems under examination.	1999	85572
fine-needle aspiration cytology.		1999	89365
development of an endosseous dental implant (iii).		1999	96476
successful treatment of hepatic venoocclusive disease in a bone marrow transplant patient with orthotopic liver transplantation.		1999	2326879
epileptogenic effect of mianserin.		1999	91069