Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| cytokine responses in primary and secondary respiratory syncytial virus infections. | primary respiratory syncytial virus (rsv) infections are characterized by high levels of il-8 and an intense neutrophilia. little is known about the cytokine responses in secondary infections. preschool children experiencing rsv secondary infections were recruited from the siblings of infants admitted to hospital with rsv acute bronchiolitis. | 2016 | 26882371 |
| new insight into the pathogenesis of minimal change nephrotic syndrome: role of the persistence of respiratory tract virus in immune disorders. | the pathogenesis of minimal change nephrotic syndrome (mcns) is a complex clinical problem which, unfortunately, has been in need of significant breakthroughs for decades. improved understanding of the mechanisms is important to develop effective treatment strategies. to our knowledge, the pathogenesis of mcns is multifactorial, involving both intrinsic and extrinsic factors, reasonable to be regarded as a "long chain" cascade reaction. current studies implicating that the disease could probably ... | 2016 | 26876386 |
| children hospitalized with rhinovirus bronchiolitis have asthma-like characteristics. | children with bronchiolitis often are considered a homogeneous group. however, in a multicenter, prospective study of 2207 young children hospitalized for bronchiolitis, we found that children with respiratory syncytial virus detected differ from those with rhinovirus detected; the latter patients resemble older children with asthma, including more frequent treatment with corticosteroids. | 2016 | 26875009 |
| cathelicidins have direct antiviral activity against respiratory syncytial virus in vitro and protective function in vivo in mice and humans. | respiratory syncytial virus (rsv) is a leading cause of respiratory tract infection in infants, causing significant morbidity and mortality. no vaccine or specific, effective treatment is currently available. a more complete understanding of the key components of effective host response to rsv and novel preventative and therapeutic interventions are urgently required. cathelicidins are host defense peptides, expressed in the inflamed lung, with key microbicidal and modulatory roles in innate hos ... | 2016 | 26873992 |
| meeting report: 4th isirv antiviral group conference: novel antiviral therapies for influenza and other respiratory viruses. | the international society for influenza and other respiratory virus diseases (isirv) held its 4th antiviral group conference at the university of texas on 2-4 june, 2015. with emerging resistance to the drugs currently licensed for treatment and prophylaxis of influenza viruses, primarily the neuraminidase inhibitor oseltamivir phosphate (tamiflu) and the m2 inhibitors amantadine and rimantadine, and the lack of effective interventions against other respiratory viruses, the 3-day programme focus ... | 2016 | 26872862 |
| experimental animal model for analyzing immunobiological responses following vaccination with formalin-inactivated respiratory syncytial virus. | formalin-inactivated respiratory syncytial virus (fi-rsv) vaccine was developed in the 1960s. however, this vaccine does not prevent infection in rsv-naïve recipients and has the paradoxical effect of increasing the severity of rsv illness following natural infection, which has been a major obstacle to developing rsv vaccines. several experimental animal models for determining the cause of the severe symptoms in fi-rsv recipients have been developed. in the present study, cotton rats immunized w ... | 2016 | 26865035 |
| virus vs. virus: adenovirus vectored vaccine to defeat respiratory syncytial virus. | 2016 | 28149851 | |
| a sensitive surface-enhanced raman scattering enzyme-catalyzed immunoassay of respiratory syncytial virus. | respiratory viruses have become a major global health challenge which would benefit from advances in screening methods for early diagnosis. respiratory syncytial virus (rsv) is one of the most important pathogen causing severe lower respiratory tract infections. here we present a novel surface-enhanced raman scattering (sers) enzyme-catalyzed immunoassay of rsv by employing peroxidase substrate 3, 3'-5, 5'-tetramethylbenzidine (tmb) as raman molecule. horseradish peroxidase (hrp) attached to the ... | 2016 | 26653454 |
| a randomized placebo controlled trial of ibuprofen for respiratory syncytial virus infection in a bovine model. | respiratory syncytial virus (rsv) is the most common cause of bronchiolitis and hospital admission in infants. an analogous disease occurs in cattle and costs us agriculture a billion dollars a year. rsv causes much of its morbidity indirectly via adverse effects of the host response to the virus. rsv is accompanied by elevated prostaglandin e2 (pge2) which is followed by neutrophil led inflammation in the lung. ibuprofen is a prototypical non-steroidal anti-inflammatory drug that decreases pge2 ... | 2016 | 27073858 |
| do pollution and climate influence respiratory tract infections in children? | to review if pollution and climate changes can influence respiratory tract infections in children. | 2016 | 25004275 |
| curcumin modified silver nanoparticles for highly efficient inhibition of respiratory syncytial virus infection. | interactions between nanoparticles and viruses have attracted increasing attention due to the antiviral activity of nanoparticles and the resulting possibility to be employed as biomedical interventions. in this contribution, we developed a very simple route to prepare uniform and stable silver nanoparticles (agnps) with antiviral properties by using curcumin, which is a member of the ginger family isolated from rhizomes of the perennial herb curcuma longa and has a wide range of biological acti ... | 2016 | 26781043 |
| rapid antigen detection test for respiratory syncytial virus diagnosis as a diagnostic tool. | the aim of this study was to evaluate the quickvue(®) rsv test kit (quidel corp, ca, usa) as a screening tool for respiratory syncytial virus in children with acute respiratory disease in comparison with the indirect immunofluorescence assay as gold standard. in brazil, rapid antigen detection tests for respiratory syncytial virus are not routinely utilized as a diagnostic tool, except for the diagnosis of dengue and influenza. | 2016 | 27889321 |
| a cross-study biomarker signature of human bronchial epithelial cells infected with respiratory syncytial virus. | respiratory syncytial virus (rsv) is a major cause of lower respiratory tract infections in children, elderly, and immunocompromised individuals. despite of advances in diagnosis and treatment, biomarkers of rsv infection are still unclear. to understand the host response and propose signatures of rsv infection, previous studies evaluated the transcriptional profile of the human bronchial epithelial cell line-beas-2b-infected with different strains of this virus. however, the evolution of statis ... | 2016 | 27274726 |
| respiratory syncytial virus seasonality in brazil: implications for the immunisation policy for at-risk populations. | respiratory syncytial virus (rsv) infection is the leading cause of hospitalisation for respiratory diseases among children under 5 years old. the aim of this study was to analyse rsv seasonality in the five distinct regions of brazil using time series analysis (wavelet and fourier series) of the following indicators: monthly positivity of the immunofluorescence reaction for rsv identified by virologic surveillance system, and rate of hospitalisations per bronchiolitis and pneumonia due to rsv i ... | 2016 | 27120006 |
| nigrodiquinone a, a hydroanthraquinone dimer containing a rare c-9-c-7' linkage from a zoanthid-derived nigrospora sp. fungus. | one new hydroanthraquinone dimer with a rare c-9-c-7' linkage, nigrodiquinone a (1), and four known anthraquinone monomers 2-5, were isolated from a fungus nigrospora sp. obtained from the zoanthid palythoa haddoni collected in the south china sea. the structure of 1 was established through extensive nmr spectroscopy, and the absolute configuration was elucidated by comparing computed electronic circular dichroism (ecd) and optical rotations (or) with experimental results. all the compounds were ... | 2016 | 27005638 |
| upper respiratory tract infection among dialysis patients. | upper respiratory tract infection (urti) occurs frequently in the general population and is considered a benign self-limited disease. dialysis patients constitute a high risk population whose morbidity and mortality rate as a result of urti is unknown. | 2016 | 28471606 |
| evaluation of a new rapid diagnostic test for the detection of influenza and rsv. | influenza viruses and respiratory syncytial virus (rsv) can cause an acute respiratory disease that occurs seasonally in epidemic waves. this retrospective study was conducted to evaluate the sofia(®) influenza a+b and the sofia(®) rsv fluorescence immunoassays (fias), two novel rapid detection tests (rdts) for influenza a and b and rsv. | 2016 | 26139303 |
| the logistics and coordination of respiratory syncytial virus immunoprophylaxis use among us pediatric specialists. | this study was conducted to survey us pediatric specialists about administration of respiratory syncytial virus (rsv) immunoprophylaxis, communication patterns among physicians and parents, and barriers to access. separate surveys were sent to neonatologists, pediatricians, pediatric pulmonologists, and pediatric cardiologists. most physicians (≥93.5%) routinely recommended immunoprophylaxis to high-risk children. most respondents (≥71.8%) reported that >50.0% of eligible infants and young child ... | 2016 | 26746004 |
| respiratory syncytial virus is present in the neonatal intensive care unit. | nosocomial transmission of respiratory syncytial virus (rsv) occurs in children within the neonatal intensive care unit (nicu). during peak community rsv transmission, three swabs were collected from the nose, hand and personal clothing of visitors and health care workers (hcw) in nicu once every week for eight weeks. nasal swabs were collected from every third neonate and from any neonate clinically suspected of having a respiratory infection. environmental sampling of high touch areas was done ... | 2016 | 26174559 |
| impact of placental malaria and hypergammaglobulinemia on transplacental transfer of respiratory syncytial virus antibody in papua new guinea. | passively acquired respiratory syncytial virus (rsv) neutralizing antibody protects against rsv-associated lower respiratory infections, but placental malaria (pm) and maternal hypergammaglobulinemia might interfere with transplacental immunoglobulin transport. | 2016 | 26238686 |
| clinical and epidemiological characteristics of acute respiratory virus infections in vietnamese children. | information about viral acute respiratory infections (aris) is essential for prevention, diagnosis and treatment, but it is limited in tropical developing countries. this study described the clinical and epidemiological characteristics of aris in children hospitalized in vietnam. nasopharyngeal samples were collected from children with aris at ho chi minh city children's hospital 2 between april 2010 and may 2011 in order to detect respiratory viruses by polymerase chain reaction. viruses were f ... | 2016 | 26145204 |
| short- and long-term pulmonary outcome of palivizumab in children born extremely prematurely. | palivizumab reduces the severity of respiratory syncytial virus infection in premature infants, but whether there is a protective effect beyond the preschool age is unknown. this study sought to assess the short- and long-term effects of palivizumab immunization on respiratory morbidity and pulmonary function at school age in children born extremely prematurely. | 2016 | 26226546 |
| a randomized, blinded, controlled, dose-ranging study of a respiratory syncytial virus recombinant fusion (f) nanoparticle vaccine in healthy women of childbearing age. | respiratory syncytial virus (rsv) is a leading cause of infant morbidity and mortality. a recombinant rsv fusion protein nanoparticle vaccine (rsv f vaccine) candidate for maternal immunization was tested for safety and immunogenicity in women of childbearing age. | 2016 | 26259809 |
| outcome of the respiratory syncytial virus related acute lower respiratory tract infection among hospitalized newborns: a prospective multicenter study. | to determine the incidence and outcomes of respiratory syncytial virus (rsv)-related acute lower respiratory tract infection (alri) including morbidity, nosocomial infection and mortality among newborn infants who were admitted to the neonatal intensive care units (nicus). | 2016 | 26365531 |
| differential neutrophil activation in viral infections: enhanced tlr-7/8-mediated cxcl8 release in asthma. | respiratory viral infections are a major cause of asthma exacerbations. neutrophils accumulate in the airways and the mechanisms that link neutrophilic inflammation, viral infections and exacerbations are unclear. this study aims to investigate anti-viral responses in neutrophils from patients with and without asthma and to investigate if neutrophils can be directly activated by respiratory viruses. | 2016 | 26477783 |
| proteomic profiling of a respiratory syncytial virus-infected rat pneumonia model. | respiratory syncytial virus (rsv) is a major cause of lower respiratory tract disease in pediatric patients. our goal was to obtain a detailed understanding of the molecular pathogenesis of rsv infections by studying the protein expression profiles in rats with pneumonia. first, we successfully established a pneumonia rat model by intranasally injecting rsv. the differentially expressed proteins in lung tissues of rsv-infected rats compared with those of the controls were analyzed by using 2-dim ... | 2016 | 26370426 |
| treatment with novel rsv ig ri-002 controls viral replication and reduces pulmonary damage in immunocompromised sigmodon hispidus. | respiratory syncytial virus (rsv) is a significant cause of bronchiolitis and pneumonia in several high health risk populations, including infants, elderly and immunocompromised individuals. mortality in hematopoietic stem cell transplant recipients with lower respiratory tract rsv infection can exceed 80%. it has been shown that rsv replication in immunosuppressed individuals is significantly prolonged, but the contribution of pulmonary damage, if any, to the pathogenesis of rsv disease in this ... | 2016 | 26367224 |
| interleukin-4 polymorphism is associated with severity of respiratory syncytial virus infection. | respiratory syncytial virus (rsv) infection is a major health problem in young children. this study aimed to investigate whether the interleukin (il)-4 -590c/t and -33 c/t polymorphisms were associated with the susceptibility to rsv infection in chinese han children and with the severity of the infection. | 2016 | 26289664 |
| respiratory syncytial virus preterm (32-36 completed weeks of gestation) risk estimation measure for rsv hospitalization in ireland: a prospective study. | in several countries, respiratory syncytial virus prophylaxis is offered to late preterm infants who are at escalated risk of respiratory syncytial virus hospitalization (rsvh). however, targeted prophylaxis should be informed by country-specific data. this study, which uniquely includes 36 weeks of gestational age (ga) infants, aims to establish the risk factors for rsvh in 32-36 weeks of ga infants in ireland. | 2016 | 26379160 |
| predictors of severe disease in a hospitalized population of children with acute viral lower respiratory tract infections. | although predictors of severe viral acute lower respiratory infections (alris) in children have been reported, there have been few research studies performed in low- and middle-income countries (lmic). the aim of the present study was to determine predictors of disease severity in a population of colombian children <5 years of age with alri. in a prospective cohort study, we determined independent predictors of severe alri in a hospitalized population of children under 5 years old with alri duri ... | 2016 | 26403374 |
| perceived risk of severe respiratory syncytial virus disease and immunoprophylaxis use among us pediatric specialists. | this study was conducted to assess the perception of us pediatric specialists of respiratory syncytial virus (rsv) disease risk and determine their clinical practices regarding immunoprophylaxis for high-risk children. separate surveys were sent to neonatologists, pediatricians, pediatric pulmonologists, and pediatric cardiologists. data were collected using structured questions requiring quantitative responses. most neonatologists and pediatricians (>82.7%) reported a high clinical need for rsv ... | 2016 | 26400767 |
| risk factors for hospitalization for respiratory syncytial virus infection: a population-based cohort study of danish children. | the aim of this study is to identify the risk factors for hospitalization for respiratory syncytial virus (rsv) infection in danish children. | 2016 | 26398871 |
| emergency department syndromic surveillance providing early warning of seasonal respiratory activity in england. | seasonal respiratory infections place an increased burden on health services annually. we used a sentinel emergency department syndromic surveillance system to understand the factors driving respiratory attendances at emergency departments (eds) in england. trends in different respiratory indicators were observed to peak at different points during winter, with further variation observed in the distribution of attendances by age. multiple linear regression analysis revealed acute respiratory infe ... | 2016 | 26415918 |
| mip-1α level in nasopharyngeal aspirates at the first wheezing episode predicts recurrent wheezing. | respiratory virus-induced wheezing, such as that induced by respiratory syncytial virus (rsv) and human rhinovirus, is an important risk factor for recurrent wheezing and childhood asthma. however, no biomarkers for predicting recurrent wheezing have been identified. | 2016 | 26494023 |
| interference between respiratory syncytial virus and rhinovirus in respiratory tract infections in children. | an acute viral respiratory tract infection might prevent infections by other viruses because of the antiviral innate immune response. however, with the use of pcr methods, simultaneous detection of two or more respiratory viruses is frequent. we analysed the effect of respiratory syncytial virus (rsv) infection on the occurrence of simultaneous rhinovirus (rv) infection in children within a birth cohort study setting. we used pcr for virus detection in nasal swabs collected from children with an ... | 2016 | 26482269 |
| respiratory syncytial virus induces phosphorylation of mtor at ser2448 in cd8 t cells from nasal washes of infected infants. | respiratory syncytial virus (rsv)-specific cd8(+) t cell responses do not protect against reinfection. activation of mammalian target of rapamycin (mtor) impairs memory cd8(+) t cell differentiation. our hypothesis was that rsv inhibits the formation of cd8(+) t cells memory responses through mtor activation. to explore this, human and mouse t cells were used. rsv induced mtor phosphorylation at ser2448 in cd8 t cells. mtor activation by rsv was completely inhibited using rapamycin. rsv-infected ... | 2016 | 26437614 |
| spatial clusters of child lower respiratory illnesses associated with community-level risk factors. | identifying geographic areas with increased incidence of disease may elucidate community-level risk factors for intervention development. lower respiratory illnesses (lris) are the leading cause of death in children and are associated with other morbidities. we assessed geographic clustering of lris and evaluated if these spatial patterns and associated risk factors differed by phenotype. participants enrolled at birth in the tucson children's respiratory study were followed through age three fo ... | 2016 | 26436763 |
| aln-rsv01 for prevention of bronchiolitis obliterans syndrome after respiratory syncytial virus infection in lung transplant recipients. | respiratory syncytial virus (rsv) infection in lung transplant (ltx) patients is associated with an increased incidence of bronchiolitis obliterans syndrome (bos). aln-rsv01 is a small interfering rna targeting rsv replication that was shown in an earlier phase 2a trial to be safe and to reduce the incidence of bos when compared with placebo. | 2016 | 26452996 |
| virus type and genomic load in acute bronchiolitis: severity and treatment response with inhaled adrenaline. | acute bronchiolitis frequently causes infant hospitalization. studies on different viruses or viral genomic load and disease severity or treatment effect have had conflicting results. we aimed to investigate whether the presence or concentration of individual or multiple viruses were associated with disease severity in acute bronchiolitis and to evaluate whether detected viruses modified the response to inhaled racemic adrenaline. | 2016 | 26508124 |
| recent advances in the development of subunit-based rsv vaccines. | respiratory syncytial virus (rsv) is a major cause of lower respiratory tract infections causing pneumonia and bronchiolitis in infants. rsv also causes serious illness in elderly populations, immunocompromised patients and individuals with pulmonary or cardiac problems. the significant morbidity and mortality associated with rsv infection have prompted interest in rsv vaccine development. in the 1960s, a formalin-inactivated vaccine trial failed to protect children, and indeed enhanced patholog ... | 2016 | 26506139 |
| where are we with rsv prophylaxis? | respiratory syncytial virus (rsv) is a predictable, seasonal disease with significant morbidity and mortality in children below 24 months. prophylaxis, which decreases hospitalisation in those most vulnerable to the disease, has been available since 1998. pharmacological prophylaxis is however, expensive and requires good infrastructure to deliver. it is out of reach for many patients in low-income and middle-income countries where mortality is highest. this article looks at the pathophysiology ... | 2016 | 26510447 |
| downregulation of matrix metalloproteinase‑19 induced by respiratory syncytial viral infection affects the interaction between epithelial cells and fibroblasts. | the present study was designed to examine the expression and function of matrix metalloproteinase‑19 (mmp‑19), which is downregulated following respiratory syncytial virus (rsv) infection. the diverse expression levels of mmp were examined using a designed cdna expression array. the expression and secretion of mmp‑19 was examined using reverse transcription‑quantitative polymerase chain reaction (rt‑qpcr) analysis and elisa, respectively. the proliferation of epithelial cells and lung fibroblast ... | 2016 | 26548962 |
| maternal high-fat hypercaloric diet during pregnancy results in persistent metabolic and respiratory abnormalities in offspring. | we have shown in a previous population-based study significant correlation between childhood asthma and early abnormalities of lipid and glucose metabolism. this study's specific aim was to determine whether maternal nutrition in pregnancy affects postnatal metabolic and respiratory outcomes in the offspring. | 2016 | 26539661 |
| prenatal versus postnatal tobacco smoke exposure and intensive care use in children hospitalized with bronchiolitis. | among children hospitalized with bronchiolitis, we examined the associations between in utero exposure to maternal cigarette smoking, postnatal tobacco smoke exposure, and risk of admission to the intensive care unit (icu). | 2016 | 26555856 |
| recombinant measles aik-c vaccine strain expressing heterologous virus antigens. | further attenuated measles vaccines were developed more than 50 years ago and have been used throughout the world. recombinant measles vaccine candidates have been developed and express several heterologous virus protective antigens. immunogenicity and protective actions were confirmed using experimental animals: transgenic mice, cotton rats, and primates. the recent development of measles vaccine-based vectored vaccine candidates has been reviewed and some information on recombinant measles vac ... | 2016 | 26562316 |
| respiratory syncytial virus activity and climate parameters during a 12-year period. | the epidemic pattern of respiratory syncytial virus (rsv) infection during long periods and the factors that determine seasonality are not well studied. in order to correlate the rsv epidemic activity with climate parameters, we conducted a retrospective study of children (0-14 year) who were hospitalized because of respiratory tract infection and had an rsv test performed in the major tertiary pediatric hospital of greece during a 12-year period (2002-2013). daily data regarding temperature and ... | 2016 | 26575521 |
| prematurity and the burden of influenza and respiratory syncytial virus disease. | respiratory morbidity of former preterm infants and especially those with bronchopulmonary dysplasia (bpd) is high during infancy and early childhood. | 2016 | 26582294 |
| high burden of rsv hospitalization in very young children: a data linkage study. | linked administrative population data were used to estimate the burden of childhood respiratory syncytial virus (rsv) hospitalization in an australian cohort aged <5 years. rsv-coded hospitalizations data were extracted for all children aged <5 years born in new south wales (nsw), australia between 2001 and 2010. incidence was calculated as the total number of new episodes of rsv hospitalization divided by the child-years at risk. mean cost per episode of rsv hospitalization was estimated using ... | 2016 | 26626237 |
| maternal immunization with respiratory syncytial virus fusion protein formulated with a novel combination adjuvant provides protection from rsv in newborn lambs. | respiratory syncytial virus (rsv) is the causative agent of serious upper and lower respiratory tract infections in newborns and infants. protection from rsv is crucial for neonates, and maternal immunization is one approach that holds promise for providing immediate protection to young infants against severe rsv infection. we previously reported efficacy of a subunit vaccine consisting of the fusion (f) protein formulated with a novel adjuvant (δf/triadj) in neonates. the goal of the current st ... | 2016 | 26616551 |
| immunomodulator plasmid projected by systems biology as a candidate for the development of adjunctive therapy for respiratory syncytial virus infection. | an imbalance in th1/th2 cytokine immune response has been described to influence the pathogenesis of respiratory syncytial virus (rsv) acute bronchiolitis and the severity of infection. th2-driven response has been well described under first rsv vaccine (formalin-inactivated rsv vaccine antigens) and replicated in some conditions for rsv-infected mice, in which a th2-dependent lung eosinophilia increases illness severity, accompanied of tissue damage. currently, several prototypes of rsv vaccine ... | 2016 | 26601594 |
| humidity: a review and primer on atmospheric moisture and human health. | research examining associations between weather and human health frequently includes the effects of atmospheric humidity. a large number of humidity variables have been developed for numerous purposes, but little guidance is available to health researchers regarding appropriate variable selection. we examine a suite of commonly used humidity variables and summarize both the medical and biometeorological literature on associations between humidity and human health. as an example of the importance ... | 2016 | 26599589 |
| etiology of pneumonia in a pediatric population with high pneumococcal vaccine coverage: a prospective study. | improved childhood immunizations programs, especially the introduction of pneumococcal vaccination, better diagnostic methods and the importance of reduced antibiotic misuse, make this a critical time to increase knowledge on the etiology of pediatric pneumonia. our main objective was to identify the contribution of various microbiological species that causes pneumonia in previously healthy children and adolescents in a population with high pneumococcal conjugate vaccine coverage. | 2016 | 26599568 |
| agonistic 4-1bb antibody fails to reduce disease burden during acute respiratory syncytial virus (rsv) infection. | respiratory syncytial virus (rsv) remains a leading cause of infant morbidity and mortality worldwide. despite this, there are limited therapeutic options. cd8 t cells have an integral role in controlling viral infections; strategies to enhance these responses may be clinically relevant. the t cell costimulatory receptor, 4-1bb, is known to play a role in expansion of antiviral cd8 t cells. in this study, we examined the effect of agonistic 4-1bb antibody at the time of rsv infection in mice. we ... | 2016 | 26597692 |
| tlr3 activation increases chemokine expression in human fetal airway smooth muscle cells. | viral infections, such as respiratory syncytial virus and rhinovirus, adversely affect neonatal and pediatric populations, resulting in significant lung morbidity, including acute asthma exacerbation. studies in adults have demonstrated that human airway smooth muscle (asm) cells modulate inflammation through their ability to secrete inflammatory cytokines and chemokines. the role of asm in the developing airway during infection remains undefined. in our study, we used human fetal asm cells as a ... | 2016 | 26589477 |
| respiratory syncytial virus shedding by children hospitalized with lower respiratory tract infection. | children with respiratory syncytial virus (rsv) infection shed virus for variable periods. the aim of this study was to quantify the viral load in nasopharyngeal aspirates of children with rsv throughout their hospitalization. this study included 37 children who were admitted with a diagnosis of rsv infection based on a positive rapid diagnostic test. nasopharyngeal aspirates were collected from patients every day, from admission to discharge. viral detection and quantification were performed us ... | 2016 | 26588816 |
| molecular mechanism of respiratory syncytial virus fusion inhibitors. | respiratory syncytial virus (rsv) is a leading cause of pneumonia and bronchiolitis in young children and the elderly. therapeutic small molecules have been developed that bind the rsv f glycoprotein and inhibit membrane fusion, yet their binding sites and molecular mechanisms of action remain largely unknown. here we show that these inhibitors bind to a three-fold-symmetric pocket within the central cavity of the metastable prefusion conformation of rsv f. inhibitor binding stabilizes this conf ... | 2016 | 26641933 |
| understanding respiratory syncytial virus (rsv) vaccine development and aspects of disease pathogenesis. | respiratory syncytial virus (rsv) is the most important cause of lower respiratory tract infections causing bronchiolitis and some mortality in young children and the elderly. despite decades of research there is no licensed rsv vaccine. although significant advances have been made in understanding the immune factors responsible for inducing vaccine-enhanced disease in animal models, less information is available for humans. in this review, we discuss the different types of rsv vaccines and thei ... | 2016 | 26641318 |
| rsv vaccine use--the missing data. | respiratory syncytial virus (rsv) infection is the most important cause of hospitalization in infants and is one of the leading global causes of infant mortality and as such its prevention through vaccination is a public health priority. while essential for the successful implementation of vaccine programs, there remains a paucity of data on the epidemiology of the virus in different settings and age groups and limited knowledge about virus transmission and the health-care costs of the disease. ... | 2016 | 26636902 |
| effectiveness of palivizumab in children with childhood interstitial lung disease: the french experience. | there is a lack of evidence concerning the effectiveness of immunoprophylaxis with palivizumab in children with childhood interstitial lung disease (child). in this retrospective study, we evaluated the effectiveness of palivizumab for decreasing the rate of rsv-related hospitalizations in children under the age of 24 months with child treated with corticosteroids. | 2016 | 26636747 |
| baculovirus vectors expressing f proteins in combination with virus-induced signaling adaptor (visa) molecules confer protection against respiratory syncytial virus infection. | baculovirus has been exploited for use as a novel vaccine vector. to investigate the feasibility and efficacy of recombinant baculoviruses (rbvs) expressing respiratory syncytial virus (rsv) fusion (f) proteins, four constructs (bac-tf/64, bac-cf, bac-cf/tf64 and bac-cf/tf64-visa) were generated. bac-tf64 displays the f ectodomain (tf) on the envelope of rbvs, whereas bac-cf expresses full-length f protein in transduced mammalian cells. bac-cf/tf64 not only displays tf on the envelope but also e ... | 2016 | 26643933 |
| prospective clinical and serological follow-up in early childhood reveals a high rate of subclinical rsv infection and a relatively high reinfection rate within the first 3 years of life. | children encounter repeated respiratory tract infections during their early life. we conducted a prospective clinical and serological follow-up study to estimate the respiratory syncytial virus (rsv) primary infection and reinfection rates in early childhood. sera were collected from 291 healthy children at the ages of 13, 24 and 36 months and antibody levels against rsv antigens were determined by enzyme immunoassay. the rt-pcr method was also used for identifying the possible presence of rsv i ... | 2016 | 26732801 |
| post-bronchiolitis use of asthma medication: a prospective 1-year follow-up study. | our aim was to evaluate the association between viral findings during bronchiolitis and the use of asthma controller medication (primary outcome) and systemic corticosteroids (secondary outcome) during the first post-bronchiolitis year. | 2016 | 26658529 |
| reduced expression of hla-dr on monocytes during severe respiratory syncytial virus infections. | respiratory syncytial virus (rsv) is a common cause of bronchiolitis in infants with a wide spectrum of disease severity. besides environmental and genetic factors, it is thought that the innate immune system plays a pivotal role. the aim of this study was to investigate the expression of immune receptors on monocytes and the in vitro responsiveness from infants with severe rsv infections. | 2016 | 26658377 |
| population-based analysis of bronchiolitis epidemiology in valencia, spain. | there is a lack of european epidemiologic population-based studies on bronchiolitis and respiratory syncytial virus (rsv) bronchiolitis including both hospitalizations and primary care attendance. | 2016 | 26658376 |
| protection against respiratory syncytial virus by inactivated influenza virus carrying a fusion protein neutralizing epitope in a chimeric hemagglutinin. | a desirable vaccine against respiratory syncytial virus (rsv) should induce neutralizing antibodies without eliciting abnormal t cell responses to avoid vaccine-enhanced pathology. in an approach to deliver rsv neutralizing epitopes without rsv-specific t cell antigens, we genetically engineered chimeric influenza virus expressing rsv f262-276 neutralizing epitopes in the globular head domain as a chimeric hemagglutinin (ha) protein. immunization of mice with formalin-inactivated recombinant chi ... | 2016 | 26656630 |
| antiviral benzofurans from eupatorium chinense. | eleven benzofuran dimers, (+)-dieupachinins a-e, (-)-dieupachinins a-e and dieupachinin f, a benzofuran trimer trieupachinin a, as well as seven known compounds were isolated from the roots of eupatorium chinense. the enantiomers of racemates dieupachinins a-e were separated by chiral hplc. the structures with absolute configurations were elucidated on the basis of spectroscopic data, x-ray diffraction analysis, and circular dichroism experiments. the isolated compounds were evaluated for their ... | 2016 | 26675360 |
| flt3 ligand improves the innate response to respiratory syncytial virus and limits lung disease upon rsv reexposure in neonate mice. | respiratory syncytial virus (rsv) causes severe bronchiolitis in infants worldwide. the immunological factors responsible for rsv susceptibility in infants are poorly understood. here, we used the balb/c mouse model of neonatal rsv infection to study the mechanisms leading to severe disease upon reexposure to the virus when adults. two major deficiencies in neonatal lung innate responses were found: a poor dcs mobilization, and a weak engagement of the ifni pathway. the administration of flt3 li ... | 2016 | 26681580 |
| who informal consultation on surveillance of respiratory syncytial virus on the who global influenza surveillance and response system (gisrs) platform, 25–27 march 2015, geneva, switzerland. | 2016 | 26753193 | |
| phenotype and hierarchy of two transgenic t cell lines targeting the respiratory syncytial virus kdm282-90 epitope is transfer dose-dependent. | in this study, we compared two lines of transgenic cd8+ t cells specific for the same kdm282-90 epitope of respiratory syncytial virus in the cb6f1 hybrid mouse model. here we found that these two transgenic lines had similar in vivo abilities to control viral load after respiratory syncytial virus infection using adoptive transfer. transfer of the trbv13-2 line resulted in higher levels of il-6 and mip1-α in the lung than trbv13-1 transfer. interestingly, when large numbers of cells were co-tra ... | 2016 | 26752171 |
| human cathelicidin, ll-37, inhibits respiratory syncytial virus infection in polarized airway epithelial cells. | respiratory syncytial virus (rsv) is a major cause of severe lower respiratory tract illness in young children worldwide. treatment options for severe rsv disease remain limited and the development of therapeutic treatment strategies remains a priority. ll-37, a small cationic host defense peptide involved in anti-inflammatory and anti-bacterial responses, reduces replication of or infection by multiple viruses, including influenza virus, in vitro, and protects against lethal challenge with infl ... | 2016 | 26732674 |
| outcomes of respiratory syncytial virus immunoprophylaxis in infants using an abbreviated dosing regimen of palivizumab. | 2016 | 26720836 | |
| antiviral activity of the "virus blocking factor" (vbf) derived i.a. from pelargonium extract and sambucus juice against different human-pathogenic cold viruses in vitro. | the in-vitro antiviral activity of the "virus blocking factor" (vbf), a combination of pelargonium extract and sambucus juice with addition of betaglucan 1,3 / 1,6, zincum gluconium, acidum ascorbicum, was studied against human pathogenic viruses: influenza a h1n1 (flua h1n1), rhinovirus b subtype 14 (hrv14), respiratory syncytial virus (rsv), parainfluenzavirus subtype 3 (para 3), and adenovirus c subtype 5 (adeno 5). | 2016 | 28478414 |
| contamination of healthcare workers' mobile phones by epidemic viruses. | mobile phones (mps) are potential reservoirs of nosocomial bacteria, but few data are available concerning viruses. we aimed to evaluate the presence of virus rna from epidemic viruses including metapneumovirus, respiratory syncytial virus, influenza viruses, rotavirus (rv) and norovirus on the mps used by healthcare workers (hcws) and to relate it to hygiene measures. an anonymous behavioural questionnaire about mp use at hospital was administered to the hcws of four adult and paediatric depart ... | 2016 | 26713553 |
| trends in respiratory syncytial virus bronchiolitis hospitalizations in children less than 1 year: 2004-2012. | to analyze trends in health outcomes and the influence of risk factors in children under 1 year with acute bronchiolitis due to respiratory syncytial virus (rsv bronchiolitis). a risk-adjustment model for rsv bronchiolitis in-hospital mortality was also developed. | 2016 | 26709735 |
| acute respiratory infections in children and adolescents with acute lymphoblastic leukemia. | knowledge regarding the incidence, clinical course, and impact of respiratory viral infections in children with acute lymphoblastic leukemia (all) is limited. | 2016 | 26700662 |
| pre-birth cohort study of atopic dermatitis and severe bronchiolitis during infancy. | infants hospitalized for bronchiolitis (i.e. severe bronchiolitis) are at increased risk of childhood asthma. there are many known risk factors for severe bronchiolitis, including cardiac and pulmonary diseases. less is known about the association between atopic diseases and risk of severe bronchiolitis. we sought to further examine risk factors for severe bronchiolitis, focusing on atopic dermatitis (ad). | 2016 | 26766307 |
| [respiratory syncytial virus outbreak in a tertiary hospital neonatal intensive care unit]. | investigation and control of a respiratory syncytial virus (rsv) outbreak that affected the neonatal intensive care unit (nicu) of a university hospital from october to december 2012. | 2016 | 26776167 |
| neonatal respiratory syncytial virus infection has an effect on lung inflammation and the cd4(+) cd25(+) t cell subpopulation during ovalbumin sensitization in adult mice. | in balb/c adult mice, respiratory syncytial virus (rsv) infection enhances the degree of lung inflammation before and/or after ovalbumin (ova) respiratory sensitization. however, it is unclear whether rsv infection in newborn mice has an effect on the immune response to ova respiratory sensitization in adult mice. the aim of this study was to determine if rsv neonatal infection alters t cd4(+) population and lung inflammation during ova respiratory sensitization in adult mice. balb/c mice were i ... | 2016 | 26990762 |
| performance evaluation of four rapid antigen tests for the detection of respiratory syncytial virus. | rapid identification of respiratory syncytial virus (rsv) is important in the management of infected patients. rapid diagnostic tests (rdt) are widely used for this purpose. this study aimed to evaluate the clinical performance of four rsv antigen tests including the binaxnow rsv card test, sd bioline rsv test, bd veritor rsv test, and humasis rsv antigen test in comparison with real-time rt-pcr as the reference method. nasopharyngeal swabs were collected from 280 patients with symptoms of lower ... | 2016 | 26990654 |
| outbreak of respiratory syncytial virus (rsv) infection in immunocompromised adults on a hematology ward. | we describe an outbreak of respiratory syncytial virus (rsv) infection on a hematology ward without allogeneic stem cell transplant patients. twelve patients and one staff member infected with rsv were identified from the laboratory database. five patients had lower respiratory tract infection, seven had upper respiratory tract infection, one was asymptomatic, and there were two (15.4%) deaths. most patients had overlapping periods of potential infectiousness on the ward. sequencing was possible ... | 2016 | 26990584 |
| determinants of early life immune responses to rsv infection. | respiratory syncytial virus causes significant morbidity and mortality in both developed and developing countries, and a vaccine that adequately protects from severe disease remains an important unmet need. rsv disease has an inordinate impact on the very young, and the physical and immunological immaturity of early life complicates vaccine design. defining and targeting the functional capacities of early life immune responses and controlling responses during primary antigen exposure with select ... | 2016 | 26986236 |
| association between secondary thrombocytosis and viral respiratory tract infections in children. | secondary thrombocytosis (st) is frequently observed in children with a variety of clinical conditions. the leading cause of st is respiratory tract infection (rti) in children. nasopharyngeal aspirate samples were collected and assessed for common respiratory viruses. the relationships between virus infections and secondary thrombocytosis were analyzed retrospectively. the blood platelet count and the presence of respiratory viruses were determined for 3156 rti patients, and 817 (25.9%) cases w ... | 2016 | 26965460 |
| respiratory syncytial virus infection and bronchial hyperreactivity in children up to two years of age in correlation with atopy. | bronchiolitis in early childhood caused by respiratory syncytial virus (rsv) is considered to be important risk factor of the recurrent wheezing and asthma development. the aim of this study was to examine the frequency of rsv infection and atopy in children up to two years of age and to determine their correlation with bronchial hyperreactivity. | 2016 | 26964386 |
| implementation of american academy of pediatrics guidelines for palivizumab prophylaxis in a pediatric hospital. | one hospital's implementation of revised american academy of pediatrics (aap) guidelines for palivizumab prophylaxis of respiratory syncytial virus (rsv) infection is described. | 2016 | 26953285 |
| prevalence of respiratory viruses among children hospitalized from respiratory infections in shenzhen, china. | the prevalence of local dominant viral etiologies is important for clinical management and prevention of common viral respiratory tract infections. unfortunately, there is limited large-scale data about common viral respiratory infection in south china. to survey dominant viral etiology and seasonality of acute respiratory infections in hospitalized children, a 4-year consecutive study was conducted in shenzhen, china. | 2016 | 26952107 |
| rsv-related thrombocytopenia associated with transient cytogenetic abnormalities in a recipient of umbilical cord blood transplantation. | respiratory syncytial virus (rsv) infections are associated with thrombocytopenia. the underlying mechanism of thrombocytopenia in this setting is unknown. herein, we report a case of rsv-related thrombocytopenia associated with transient cytogenetic abnormalities that occurred following umbilical cord blood transplantation. | 2016 | 26949553 |
| the contributions of allergic sensitization and respiratory pathogens to asthma inception. | of the chronic diseases affecting grade-school children, asthma is the most common and accounts for the greatest number of school days missed. moreover, it can influence family dynamics and function in other ways, and unfortunately, it can also be associated with mortality, particularly in the inner-city environments of the united states. thus understanding factors that lead to its development in early life is essential in developing strategies aimed at primary prevention. two risk factors that ... | 2016 | 26947979 |
| effect of gubenfangxiao decoction on respiratory syncytial virus-induced asthma and expression of asthma susceptibility gene orosomucoid 1-like protein 3 in mice. | to investigate the effect of guben-fangxiao decoction (gbfxd) on respiratory-syncytial-virus (rsv)-induced asthma and the expression of asthma susceptibility gene, orosomucoid 1-like protein 3 (ormdl3) in mice. | 2016 | 26946626 |
| a numerically subdominant cd8 t cell response to matrix protein of respiratory syncytial virus controls infection with limited immunopathology. | cd8 t cells are involved in pathogen clearance and infection-induced pathology in respiratory syncytial virus (rsv) infection. studying bulk responses masks the contribution of individual cd8 t cell subsets to protective immunity and immunopathology. in particular, the roles of subdominant responses that are potentially beneficial to the host are rarely appreciated when the focus is on magnitude instead of quality of response. here, by evaluating cd8 t cell responses in cb6f1 hybrid mice, in whi ... | 2016 | 26943673 |
| seasonal dynamics of the airborne bacterial community and selected viruses in a children's daycare center. | children's daycare centers appear to be hubs of respiratory infectious disease transmission, yet there is only limited information about the airborne microbial communities that are present in daycare centers. we have investigated the microbial community of the air in a daycare center, including seasonal dynamics in the bacterial community and the presence of specific viral pathogens. we collected filters from the heating, ventilation, and air conditioning (hvac) system of a daycare center every ... | 2016 | 26942410 |
| incorporating transmission into causal models of infectious diseases for improved understanding of the effect and impact of risk factors. | conventional measures of causality (which compare risks between exposed and unexposed individuals) do not factor in the population-scale dynamics of infectious disease transmission. we used mathematical models of 2 childhood infections (respiratory syncytial virus and rotavirus) to illustrate this problem. these models incorporated 3 causal pathways whereby malnutrition could act to increase the incidence of severe infection: increasing the proportion of infected children who develop severe infe ... | 2016 | 26940116 |
| correction: correction: molecular characterization of circulating respiratory syncytial virus (rsv) genotypes in gilgit baltistan province of pakistan during 2011-2012 winter season. | 2016 | 26938668 | |
| prediction model of rsv-hospitalization in late preterm infants: an update and validation study. | new vaccines and rsv therapeutics have been developed in the past decade. with approval of these new pharmaceuticals on the horizon, new challenges lie ahead in selecting the appropriate target population. we aimed to improve a previously published prediction model for prediction of rsv-hospitalization within the first year of life. | 2016 | 26930376 |
| clinical outcomes in outpatient respiratory syncytial virus infection in immunocompromised children. | immunocompromised patients are at high risk for morbidity and mortality due to respiratory syncytial virus (rsv) infection. increasingly, pediatric patients with malignancy or undergoing transplantation are managed primarily as outpatients. data regarding the clinical presentation and outcomes of rsv in the outpatient pediatric immunocompromised population are limited. | 2016 | 26859306 |
| spontaneous pneumothorax with subcutaneous emphysema: a rare complication of respiratory syncytial virus infection. | viral bronchiolitis is the most common lower respiratory tract infection in infants and children under the age of 2. respiratory syncytial virus (rsv) is the infecting agent in more than 50% of the cases. usually the clinical course is uneventful and complications are uncommon. secondary air leaks are a recognized rare complication of bronchiolitis, although the real incidence remains unknown. we report a case of a 21-month-old female that developed a spontaneous pneumothorax (pno) with subcutan ... | 2016 | 26858803 |
| early-life respiratory infections and asthma development: role in disease pathogenesis and potential targets for disease prevention. | this article presents recent findings and perspectives on the relationship between early-life respiratory infections and asthma inception, and discusses emerging concepts on strategies that target these infectious agents for asthma prevention. | 2016 | 26854761 |
| burden of influenza and respiratory syncytial virus infection in pregnant women and infants under 6 months in mongolia: a prospective cohort study. | pregnant women and infants under 6 months are at risk of influenza-related complications. limited information exists on their community burden of respiratory viruses. | 2016 | 26849042 |
| erratum: effect of prophylactic palivizumab on admission due to respiratory syncytial virus infection in former very low birth weight infants with bronchopulmonary dysplasia. | 2016 | 26839492 | |
| chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old. | this cochrane review was first published in 2005 and updated in 2007, 2012 and now 2015. acute bronchiolitis is the leading cause of medical emergencies during winter in children younger than two years of age. chest physiotherapy is sometimes used to assist infants in the clearance of secretions in order to decrease ventilatory effort. | 2016 | 26833493 |
| evaluation of a fluorescent immunoassay rapid test (sofia™) for detection of influenza a+b and rsv in a tertiary pediatric setting. | in response to the lack of sensitivity and reproducibility of previously marketed rapid antigen detection tests, a novel fluorescent immunoassay was recently developed. this new assay offers rapidity and automated reading. more characterization of this assay is needed. the aim of this study was to assess diagnostic performance of sofia influenza a+b and respiratory syncytial virus (rsv) while compared to traditional viral cell culture. a total of 416 respiratory samples were analyzed prospective ... | 2016 | 26827091 |