Publications

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the influence of sulfur and hair growth on stable isotope diet estimates for grizzly bears.stable isotope ratios of grizzly bear (ursus arctos) guard hair collected from bears on the lower stikine river, british columbia (bc) were analyzed to: 1) test whether measuring δ34s values improved the precision of the salmon (oncorhynchus spp.) diet fraction estimate relative to δ15n as is conventionally done, 2) investigate whether measuring δ34s values improves the separation of diet contributions of moose (alces alces), marmot (marmota caligata), and mountain goat (oreamnos americanus) and ...201728248995
group or ungroup - moose behavioural response to recolonization of wolves.predation risk is a primary motivator for prey to congregate in larger groups. a large group can be beneficial to detect predators, share predation risk among individuals and cause confusion for an attacking predator. however, forming large groups also has disadvantages like higher detection and attack rates of predators or interspecific competition. with the current recolonization of wolves (canis lupus) in scandinavia, we studied whether moose (alces alces) respond by changing grouping behavio ...201728239401
effects of interspecific interaction-linked habitat factors on moose resource selection and environmental stress.resource selection of herbivores is a complex ecological process that operates in relation to biological or non-biological factors, which may affect the feeding and movement, and subsequently their spatial distribution and environmental stress. here, we estimated moose (alces alces cameloides) resource selection for habitat variables and the effect of interspecific interactions related to roe deer (capreolus pygargus bedfordi) on its population distribution and environmental stress in the khinga ...201728128311
habitat-performance relationships of a large mammal on a predator-free island dominated by humans.the demographic consequences of changes in habitat use driven by human modification of landscape, and/or changes in climate, are important for any species. we investigated habitat-performance relationships in a declining island population of a large mammal, the moose (alces alces), in an environment that is predator-free but dominated by humans. we used a combination of demographic data, knowledge of habitat selection, and multiannual movement data of female moose (n = 17) to understand how spac ...201728070294
ungulate predation and ecological roles of wolves and coyotes in eastern north america.understanding the ecological roles of species that influence ecosystem processes is a central goal of ecology and conservation biology. eastern coyotes (canis latrans) have ascended to the role of apex predator across much of eastern north america since the extirpation of wolves (canis spp.) and there has been considerable confusion regarding their ability to prey on ungulates and their ecological niche relative to wolves. eastern wolves (c. lycaon) are thought to have been the historical top pr ...201728064464
sarcocystis entzerothi n. sp. from the european roe deer (capreolus capreolus).in the present study, we describe sarcocystis entzerothi n. sp. from the european roe deer (capreolus capreolus) based on the microscopical and dna analysis. by light microscopy (lm), cysts of s. entzerothi were spindle-shaped with pointed tips, 950-1900 × 70-150 μm in size and had 5-6 μm long finger-like cyst wall protrusions. cyst wall of s. entzerothi by transmission electron microscopy (tem) was type 10a-like; villar protrusions were up to 1.2 μm wide, densely packed, lying about 0.1 μm betw ...201727752769
relationship between cd and zn concentration in the kidneys, liver, and muscles of moose (alces alces) from north-eastern poland.the aim of the study was to evaluate the cadmium and zinc content in the kidneys and liver of moose from north-eastern poland. animals were divided with respect to their age. the mean concentration of cadmium in the kidneys of moose studied was 11.31 mg kg(-1), while in the liver it amounted to 2.68 mg kg(-1). age had a significant effect on the content of cadmium in both organs. in the muscles of most animals studied, the cadmium concentrations were below the detection limit. elevated concentra ...201727743325
high prevalence of prion protein genotype associated with resistance to chronic wasting disease in one alberta woodland caribou population.chronic wasting disease (cwd) is a prion disease found in deer, elk and moose in north america and since recently, wild reindeer in norway. caribou are at-risk to encounter cwd in areas such as alberta, canada, where the disease spreads toward caribou habitats. cwd susceptibility is modulated by species-specific polymorphisms in the prion protein gene (prnp). we sequenced prnp of woodland caribou from 9 albertan populations. in one population (chinchaga) a significantly higher frequency of the 1 ...201728350512
molecular mechanisms of chronic wasting disease prion propagation.prion disease epidemics, which have been unpredictable recurrences, are of significant concern for animal and human health. examples include kuru, once the leading cause of death among the fore people in papua new guinea and caused by mortuary feasting; bovine spongiform encephalopathy (bse) and its subsequent transmission to humans in the form of variant creutzfeldt-jakob disease (vcjd), and repeated examples of large-scale prion disease epidemics in animals caused by contaminated vaccines. the ...201728193766
de novo generation of a unique cervid prion strain using protein misfolding cyclic amplification.substantial evidence supports the hypothesis that prions are misfolded, infectious, insoluble, and protease-resistant proteins (prp(res)) devoid of instructional nucleic acid that cause transmissible spongiform encephalopathies (tses). protein misfolding cyclic amplification (pmca) has provided additional evidence that prpres acts as a template that can convert the normal cellular prion protein (prp(c)) present in uninfected normal brain homogenate (nbh) into the infectious misfolded prp(res) is ...201728144628
the structure of mammalian prions and their aggregates.prion diseases, such as creutzfeldt-jakob disease in humans, bovine spongiform encephalopathy in cattle, chronic wasting disease in cervids (i.e., deer, elk, moose, and reindeer), and sheep scrapie, are caused by the misfolding of the cellular prion protein (prp(c)) into a disease-causing conformer (prp(sc)). prp(c) is a normal, gpi-anchored protein that is expressed on the surface of neurons and other cell types. the structure of prp(c) is well understood, based on studies of recombinant prp, w ...201728109330
female- and male-specific risk factors for stroke: a systematic review and meta-analysis.the incidence of stroke is higher in men than in women. the influence of sex-specific risk factors on stroke incidence and mortality is largely unknown.201727842176
hyponatremia and short-term prognosis of patients with acute pulmonary embolism: a meta-analysis.the aim of this study was to assess the relationship between hyponatremia and the short-term prognosis of patients with acute pulmonary embolism (pe).201727839808
outcome of pancreas transplantation from donation after circulatory death compared to donation after brain death.to overcome the gap of organ shortage grafts from donation after circulatory death (dcd) can be used. this review evaluates the outcomes after dcd pancreas donation compared to donation after brain death (dbd).201727838258
implementation of a vaccine screening program at an independent community pharmacy.to implement a comprehensive vaccine screening program and to identify best practices in workflow for a vaccine screening program.201727964886
new roles in hemicellulosic sugar fermentation for the uncultivated bacteroidetes family bs11.ruminants have co-evolved with their gastrointestinal microbial communities that digest plant materials to provide energy for the host. some arctic and boreal ruminants have already shown to be vulnerable to dietary shifts caused by changing climate, yet we know little about the metabolic capacity of the ruminant microbiome in these animals. here, we use meta-omics approaches to sample rumen fluid microbial communities from alaskan moose foraging along a seasonal lignocellulose gradient. winter ...201727959345
migraine affects 1 in 10 people worldwide featuring recent rise: a systematic review and meta-analysis of community-based studies involving 6 million participants.to study the weighted average global prevalence of migraine at the community level.201728017235
secular trends in the incidence of dementia in high-income countries: a protocol of a systematic review and a planned meta-analysis.a global dementia epidemic is projected for the year 2050 with an ever-rising number of individuals living with the syndrome worldwide. however, increasingly, studies are emerging from high-income countries (hic) that show a positive trend towards a possible decrease in dementia occurrence. therefore, we aim to systematically summarise evidence regarding secular trends in the incidence of dementia in hic.201728389488
laparoendoscopic single-site surgery versus conventional laparoscopy for hysterectomy: a systematic review and meta-analysis.to assess the safety and effectiveness of less compared to conventional hysterectomy.201728357561
the prevalence extent of complementary and alternative medicine (cam) use among saudis.introduction: there is worldwide interest in the use of cam. studying cam in saudi population is important as it will reflect the influence of psychosocial, cultural and religious factors on health beliefs and behaviors. the objective of this study was to present an updated review on the use of cam practices in saudi arabia including commonly used types, common conditions for which it has been used and who uses cam. methods: this review used data from national surveys conducted in saudi arabia a ...201728344484
angiosome-directed revascularization in patients with critical limb ischemia.direct revascularization (dr), according to the angiosome concept, provides direct blood flow to the site of tissue loss in patients with critical limb ischemia (cli). dr may lead to improved outcomes; however, evidence for this is controversial. this systematic review and meta-analysis investigated the outcomes of surgical and endovascular dr compared with indirect revascularization (ir) in patients with cli.201728342514
[current dental implant design and its clinical importance].the development of clinical implant dentistry was intensively affected by dental implant design improvement and innovation, which brought about new concept, even milestone-like changes of clinical protocol. the current improvements of dental implant design and their clinical importance could be highlighted as followings: 1) the implant apical design influences the implant preliminary stability in immediate implant. the apical 3-5 mm design of implant makes implant stable in immediate implant, be ...201728326723
the value of lncrna hulc as a prognostic factor for survival of cancer outcome: a meta-analysis.growing evidence from recent studies has shown that lncrna hulc plays a role in the development of multiple carcinomas. this meta-analysis aimed to analyze available data to identify the prognostic value of hulc in multiple tumors.201728315877
seven years of workplace drug testing in italy: a systematic review and meta-analysis.in italy, workplace drug testing (wdt) is compulsory by law for specific categories of workers since 2008, offering the opportunity to compare studies conducted within a single regulatory framework.201728304140
overweight or obesity in children aged 0 to 6 and the risk of adult metabolic-syndrome: a systematic review and meta-analysis.to identify an association between overweight or obesity in early childhood and metabolic syndrome in adults.201728295797
risk factors for the development of autism spectrum disorder in children with tuberous sclerosis complex: protocol for a systematic review.tuberous sclerosis complex (tsc) is an autosomal dominant condition, caused by mutations in either the tsc1 or tsc2 gene. it has widespread systemic manifestations and is associated with significant neurological morbidity. in addition to seizures and cerebral pathology including cortical tubers, subependymal nodules, subependymal giant cell astrocytoma and abnormal white matter, there are recognised neuropsychiatric difficulties including intellectual disability, autism spectrum disorder (asd) a ...201728270230
vestibular (dys)function in children with sensorineural hearing loss: a systematic review.the objective of this study is to provide an overview of the prevalence of vestibular dysfunction in children with snhl classified according to the applied test and its corresponding sensitivity and specificity.201728264605
the healthy weights initiative: the first 1,000 participants.according to statistics canada, the number of adults who are overweight or obese rises every year in canada. as such, it is obvious that various public policies are not working. after extensive community consultation, the healthy weights initiative (hwi) started in moose jaw and expanded to regina, saskatchewan, canada.201728260865
androgen receptor gene cag repeat polymorphism and ovarian cancer risk: a meta-analysis.ovarian cancer is one of the common gynecological malignancies worldwide. it is usually diagnosed at a later stage, thus missing the best opportunity for treatment. despite the advancement of ovarian cancer treatment, the prognosis is still poor. androgen receptor (ar) may play a role in ovarian carcinogenesis. previous studies regarding the association between ar cag repeat length and ovarian cancer risk reported inconsistent results. therefore, we conducted a meta-analysis to evaluate the asso ...201728250337
aneurysm rebleeding after placement of external ventricular drainage: a systematic review and meta-analysis.the association between external ventricular drainage (evd) and aneurysm rerupture is still a controversial issue. we performed a systematic review and meta-analysis of published series reporting data of evd placement in aneurysmal subarachnoid hemorrhage (sah) with the aim to evaluate the relationship between ventricular drainage and aneurysm rebleeding.201728243810
the interrelation between hypothyroidism and glaucoma: a critical review and meta-analyses.data on the association between hypothyroidism and glaucoma are conflicting. we sought to shed light on this by conducting a critical review and meta-analyses. the meta-analyses were conducted in adherence with the widely accepted moose guidelines. using the medical subject heading (mesh) terms: hypothyroidism, myxoedema and glaucoma or intraocular pressure, case-control studies, cohort studies and cross-sectional studies were identified (pubmed) and reviewed. using meta-analysis, the relative r ...201728211200
systematic review and meta-analysis of the efficacy of epidermal grafting for wound healing.autologous skin grafting is an important method for wound coverage; however, it is an invasive procedure and can cause donor site morbidity. epidermal grafting (eg) enables epidermal transfer to wounds with minimal donor site morbidity. however, data to date have been heterogeneous. this study aims to synthesise the current evidence on eg for wound healing to establish the efficacy of this surgical technique. a comprehensive search in the medline, embase and central databases was conducted. the ...201728198101
efficacy of the intravitreal sustained-release dexamethasone implant for diabetic macular edema refractory to anti-vascular endothelial growth factor therapy: meta-analysis and clinical implications.to assess the effect on best-corrected visual acuity (bcva) and efficacy of the intravitreal sustained-release 0.7 mg dexamethasone implant (ozurdex; allergan, irvine, ca) in patients with recalcitrant diabetic macular edema (dme).201728195619
tumor necrosis factor alpha is a promising circulating biomarker for the development of obstructive sleep apnea syndrome: a meta-analysis.obstructive sleep apnea syndrome (osas) is a chronic inflammatory disorder. the relationship between tumor necrosis factor alpha (tnf-alpha) and osas has been widely evaluated, but the results thus far remain inconclusive. we thereby decided to quantify the changes of tnf-alpha between osas patients and controls by a meta-analysis. this study complies with the moose guidelines. two reviewers independently searched articles and abstracted relevant data. in total, 47 articles (59 studies) were ana ...201728187003
gastrojejunostomy tube complications - a single center experience and systematic review.gastrojejunostomy tubes (gjts) enable enteral nutrition in infants/children with feeding intolerance. however, complications may be increased in small infants. we evaluated our single-institution gjt complication rate and systematically reviewed existing literature.201728162764
serum selenium levels and prostate cancer risk: a moose-compliant meta-analysis.some observational studies have shown that elevated serum selenium levels are associated with reduced prostate cancer risk; however, not all published studies support these results. a literature search of pubmed, embase, medline, and the cochrane library up until september 2016 identified 17 studies suitable for further investigation. a meta-analysis was conducted on these studies to investigate the association between serum selenium levels and subsequent prostate cancer risk. pooled odds ratios ...201728151881
hematology journals do not sufficiently adhere to reporting guidelines: a systematic review.essentials reporting guidelines and trial/review registration aim to limit bias in research. we systematically reviewed hematology journals to examine the use of these policies. forty-eight percent of journals made no use of these policies. improving the use of reporting guidelines will improve research for all stakeholders.201728122156
the incidence of postpartum hemorrhage in pregnant women with placenta previa: a systematic review and meta-analysis.the global burden of postpartum hemorrhage (pph) in women with placenta previa is a major public health concern. although there are different reports on the incidence of pph in different countries, to date, no research has reviewed them.201728107460
prevalence of obesity and overweight in african learners: a protocol for systematic review and meta-analysis.obesity and overweight are an emerging problem in africa. obese children are at increased risk of developing hypertension, high cholesterol, orthopaedic problems and type 2 diabetes as well as increased risk of adult obesity. prevention of childhood overweight and obesity therefore needs high priority. the review approach is particularly useful in establishing whether research findings are consistent and can be generalised across populations and settings. this systematic review aims to assess th ...201728087553
a meta-analysis of the clinicopathological characteristics and survival outcomes of inflammatory bowel disease associated colorectal cancer.the current study aims to use meta-analytical techniques to compare the clinicopathological characteristics and survival outcomes of inflammatory bowel disease (ibd) associated and sporadic colorectal carcinoma (crc). patients with ibd have an established increased risk of developing crc. there is no consensus, however, on the clinicopathological characteristics and survival outcomes of ibd associated crc when compared to sporadic crc.201728078433
total bilirubin level may be a biomarker of nephropathy in type 2 diabetes mellitus: a meta-analysis of observational studies based on moose compliant.recently, the number of the studies on the relationship between the total bilirubin level (tbl) and diabetic nephropathy (dn) is increasing, but their results were not consistent. therefore, we performed a meta-analysis to analyze the relationship between tbl and the risk of dn.we searched 5 databases before october 31, 2016, and reviewed the reference list of relevant articles. the fixed or random-effects model was used to pool risk estimates. we conducted the dose-response meta-analysis to eva ...201728072721
diabetes is associated with risk of postoperative cognitive dysfunction: a meta-analysis.postoperative cognitive dysfunction (pocd) occurs frequently after surgery, particularly among older people. diabetes, chronic hyperglycemia, and a history of hypoglycemia are related to cognitive impairment, but little is known about their roles in pocd. here, we estimated their associations with risk of pocd on the basis of published epidemiological research.201728063267
association of cannabis use with the development of elevated anxiety symptoms in the general population: a meta-analysis.the directionality and magnitude of the association of cannabis use with elevated anxiety symptoms in the general population is unclear. the aim of this meta-analysis was to investigate the association of cannabis use with the development of elevated anxiety symptoms in the general population.201728053188
student experience at moose factory. 20174455660
molecular detection of bartonella spp. in deer ked (lipoptena cervi) in poland.the bacteria of the genus bartonella are obligate parasites of vertebrates. their distribution range covers almost the entire world from america, europe, asia to africa and australia. some species of bartonella are pathogenic for humans. their main vectors are blood-sucking arthropods such as fleas, ticks and blood-feeding flies. one such dipteran able to transfer vector-borne pathogens is the deer ked (lipoptena cervi) of the family hippoboscidae. this species acts as a transmitter of bartonell ...201729037227
karyotype relationships among selected deer species and cattle revealed by bovine fish probes.the cervidae family comprises more than fifty species divided into three subfamilies: capreolinae, cervinae and hydropotinae. a characteristic attribute for the species included in this family is the great karyotype diversity, with the chromosomal numbers ranging from 2n = 6 observed in female muntiacus muntjak vaginalis to 2n = 70 found in mazama gouazoubira as a result of numerous robertsonian and tandem fusions. this work reports chromosomal homologies between cattle (bos taurus, 2n = 60) and ...201729112970
yew (taxus) intoxication in free-ranging cervids.wild ruminants, including deer species (cervids) have incorrectly been regarded as refractory to yew (taxus) intoxication. this assumption has been based upon anecdotal observations of individual deer browsing on yew over time without apparent adverse effect. a single case of yew intoxication was reported in a free-ranging norwegian moose (alces alces) in 2008. the current report describes five additional cases of yew toxicosis in moose, seven in roe deer (capreolus capreolus) and two in reindee ...201729281648
brominated flame retardants and toxic elements in the meat and liver of red deer (cervus elaphus), wild boar (sus scrofa), and moose (alces alces) from latvian wildlife.in order to evaluate the contamination status of terrestrial biota in latvia, muscle and liver tissues of red deer (cervus elaphus), wild boar (sus scrofa), and moose (alces alces) were analyzed for the content of polybrominated diphenyl ethers (pbde), hexabromocyclododecane (hbcd), tetrabromobisphenol a (tbbpa), as well as cadmium and lead. the highest mean concentrations of pbdes (46.6pgg-1 wet weight (w.w.)), cadmium (0.95mgkg-1 w.w.), and lead (0.22mgkg-1 w.w.) were observed in the tissues o ...201729202283
ante-mortem detection of chronic wasting disease in recto-anal mucosa-associated lymphoid tissues from elk (cervus elaphus nelsoni) using real-time quaking-induced conversion (rt-quic) assay: a blinded collaborative study.prion diseases are transmissible spongiform encephalopathies (tses) characterized by fatal, progressive neurologic diseases with prolonged incubation periods and an accumulation of infectious misfolded prion proteins. antemortem diagnosis is often difficult due to a long asymptomatic incubation period, differences in the pathogenesis of different prions, and the presence of very low levels of infectious prion in easily accessible samples. chronic wasting disease (cwd) is a tse affecting both wil ...201729098931
endemic chronic wasting disease causes mule deer population decline in wyoming.chronic wasting disease (cwd) is a fatal transmissible spongiform encephalopathy affecting white-tailed deer (odocoileus virginianus), mule deer (odocoileus hemionus), rocky mountain elk (cervus elaphus nelsoni), and moose (alces alces shirasi) in north america. in southeastern wyoming average annual cwd prevalence in mule deer exceeds 20% and appears to contribute to regional population declines. we determined the effect of cwd on mule deer demography using age-specific, female-only, cwd transi ...201729049389
sublethal lead exposure alters movement behavior in free-ranging golden eagles.lead poisoning of animals due to ingestion of fragments from lead-based ammunition in carcasses and offal of shot wildlife is acknowledged globally and raises great concerns about potential behavioral effects leading to increased mortality risks. lead levels in blood were correlated with progress of the moose hunting season. based on analyses of tracking data, we found that even sublethal lead concentrations in blood (25 ppb, wet weight), can likely negatively affect movement behavior (flight he ...201728414429
continental divide: predicting climate-mediated fragmentation and biodiversity loss in the boreal forest.climate change threatens natural landscapes through shifting distribution and abundance of species and attendant change in the structure and function of ecosystems. however, it remains unclear how climate-mediated variation in species' environmental niche space may lead to large-scale fragmentation of species distributions, altered meta-population dynamics and gene flow, and disrupted ecosystem integrity. such change may be especially relevant when species distributions are restricted either spa ...201728505173
whole-genome sequences of odocoileus hemionus deer adenovirus isolates from deer, moose and elk are highly conserved and support a new species in the genus atadenovirus.we present the first complete genome sequence of odocoileus hemionus deer adenovirus 1 (odadv-1). this virus can cause sporadic haemorrhagic disease in cervids, although epizootics with high mortality have occurred in california. odadv-1 has been placed in the genus atadenovirus, based on partial hexon, pviii and fibre genes. ten field isolates recovered from naturally infected mule deer (odocoileus hemionus), white-tailed deer (odocoileus virginiana) and moose (alces alces) from wyoming, black- ...201728809152
x chromosome evolution in cetartiodactyla.the phenomenon of a remarkable conservation of the x chromosome in eutherian mammals has been first described by susumu ohno in 1964. a notable exception is the cetartiodactyl x chromosome, which varies widely in morphology and g-banding pattern between species. it is hypothesized that this sex chromosome has undergone multiple rearrangements that changed the centromere position and the order of syntenic segments over the last 80 million years of cetartiodactyla speciation. to investigate its ev ...201728858207
the structure of the infectious prion protein and its propagation.the prion diseases, which include creutzfeldt-jakob disease in humans, chronic wasting disease in cervids (i.e., deer, elk, moose, and reindeer), bovine spongiform encephalopathy in cattle, as well as sheep and goat scrapie, are caused by the conversion of the cellular prion protein (prp(c)) into a disease-causing conformer (prp(sc)). prp(c) is a regular, gpi-anchored protein that is expressed on the cell surface of neurons and many other cell types. the structure of prp(c) is well studied, base ...201728838667
experimental moose reduction lowers wolf density and stops decline of endangered caribou.the expansion of moose into southern british columbia caused the decline and extirpation of woodland caribou due to their shared predators, a process commonly referred to as apparent competition. using an adaptive management experiment, we tested the hypothesis that reducing moose to historic levels would reduce apparent competition and therefor recover caribou populations. nested within this broad hypothesis were three specific hypotheses: (1) sport hunting could be used to substantially reduce ...201728875080
conservation of wildlife populations: factoring in incremental disturbance.progressive anthropogenic disturbance can alter ecosystem organization potentially causing shifts from one stable state to another. this potential for ecosystem shifts must be considered when establishing targets and objectives for conservation. we ask whether a predator-prey system response to incremental anthropogenic disturbance might shift along a disturbance gradient and, if it does, whether any disturbance thresholds are evident for this system. development of linear corridors in forested ...201728649339
scavenging on a pulsed resource: quality matters for corvids but density for mammals.human food subsidies can provide predictable food sources in large quantities for wildlife species worldwide. in the boreal forest of fennoscandia, gut piles from moose (alces alces) harvest provide a potentially important food source for a range of opportunistically scavenging predators. increased populations of predators can negatively affect threatened or important game species. as a response to this, restrictions on field dressing of moose are under consideration in parts of norway. however, ...201728619108
enantioselectivity of anteiso-fatty acids in hitherto uninspected sample matrices.anteiso-fatty acids (afas) are chiral molecules due to a methyl substituent on the antepenultimate carbon of the otherwise straight acyl chain. 12-methyltetradecanoic acid (a15:0) and 14-methylhexadecanoic acid (a17:0) are the predominant afas in nature but their individual contributions e.g. to food lipids are usually low. enantioselective data has been collected in fish, bovine milk/cheese, and brussels sprouts. in this study, we determined the enantioselectivity of a15:0 and a17:0 in shea but ...201728753519
de novo comparative transcriptome analysis of genes involved in fruit morphology of pumpkin cultivars with extreme size difference and development of est-ssr markers.the genetic basis of fruit size and shape was investigated for the first time in cucurbita species and genetic loci associated with fruit morphology have been identified. although extensive genomic resources are available at present for tomato (solanum lycopersicum), cucumber (cucumis sativus), melon (cucumis melo) and watermelon (citrullus lanatus), genomic databases for cucurbita species are limited. recently, our group reported the generation of pumpkin (cucurbita pepo) transcriptome database ...201728435133
comparative metagenomics of cellulose- and poplar hydrolysate-degrading microcosms from gut microflora of the canadian beaver (castor canadensis) and north american moose (alces americanus) after long-term enrichment.to identify carbohydrate-active enzymes (cazymes) that might be particularly relevant for wood fiber processing, we performed a comparative metagenomic analysis of digestive systems from canadian beaver (castor canadensis) and north american moose (alces americanus) following 3 years of enrichment on either microcrystalline cellulose or poplar hydrolysate. in total, 9,386 genes encoding cazymes and carbohydrate-binding modules (cbms) were identified, with up to half predicted to originate from f ...201729326667
systematic review of nephrotoxicity of drugs of abuse, 2005-2016.the united states is faced with an unprecedented epidemic of drug abuse. every year thousands of americans visit the emergency departments all over the country with illicit drug related complaints. these drugs have been known to be associated with a range of renal pathologies, from reversible acute kidney injuries to debilitating irreversible conditions like renal infarction. so far, no comprehensive study or systematic review has been published that includes the commonly used street drugs and d ...201729287591
laparoscopic vs open hepatectomy for hepatocellular carcinoma in patients with cirrhosis: a meta-analysis of the long-term survival outcomes.in patients with hepatocellular carcinoma (hcc) and cirrhosis, laparoscopic hepatectomy (lh) confers short-term benefits over open hepatectomy (oh) but the long-term outcomes of this procedure are unclear. this systematic review aims to compare the long-term survival outcomes of lh and oh for patients with hcc and underlying cirrhosis.201729284151
prevalence of work-related musculoskeletal disorders among surgeons and interventionalists: a systematic review and meta-analysis.physicians in procedural specialties are at high risk for work-related musculoskeletal disorders (msds). this has been called "an impending epidemic" in the context of the looming workforce shortage; however, prevalence estimates vary by study.201729282463
protocolized laboratory screening for the medical clearance of psychiatric patients in the emergency department: a systematic review.emergency department (ed) patients with psychiatric chief complaints undergo medical screening to rule out underlying or comorbid medical illnesses prior to transfer to a psychiatric facility. this systematic review attempts to determine the clinical utility of protocolized laboratory screening for the streamlined medical clearance of ed psychiatric patients by determining the clinical significance of individual laboratory results.201729266617
incidence of malignant hyperthermia in patients undergoing general anesthesia: protocol for a systematic review and meta-analysis.malignant hyperthermia (mh) continues to be of potential concern for clinicians whenever inhalational anesthetic agents or succinylcholine are used, because mh is a potentially fatal metabolic disorder.201729245345
the impact of human leukocyte antigen mismatching on graft survival and mortality in adult renal transplantation: a protocol for a systematic review and meta-analysis.human leukocyte antigen (hla) was important biological barrier to a successful transplantation. quantitative evaluations of the effect of hla mismatching on heart, liver, umbilical cord blood, and hematopoietic stem cell transplantation, have previously been reported. in new era of immunosuppression, the reported magnitude effect of hla mismatching on survival outcomes of kidney transplantation was controversial. in addition, the current kidney allocation guideline recommendations in different c ...201729245253
fitness correlates of age at primiparity in a hunted moose population.trade-offs between fitness-related traits are predicted from the principle of resource allocation, where increased fecundity or parental investment leads to reduced future reproduction or survival. however, fitness traits can also be positively correlated due to individual differences (e.g. body mass). age at primiparity could potentially explain variation in individual fitness either because early primiparity is costly, or it may lead to higher lifetime reproductive success. based on long-term ...201729197974
assessing health care access and use among indigenous peoples in alberta: a systematic review.alberta's indigenous population is growing, yet health care access may be limited. this paper presents a comprehensive review on health care access among indigenous populations in alberta with a focus on the health care services use and barriers to health care access. scientific databases (pubmed, embase, cinahl, and psycinfo) and online search engines were systematically searched for studies and grey literature published in english between 2000 and 2013 examining health care services access, us ...201729176095
duration of untreated psychosis and neurocognitive functioning in first-episode psychosis: a systematic review and meta-analysis.previous reviews suggest there is minimal evidence for an association between duration of untreated psychosis (dup) and neurocognition. this is based on tallied findings of studies with small samples and neurocognition viewed as a single construct. we aimed to conduct a systematic review and meta-analysis examining the association between dup and individual neurocognitive domains and tests in first-episode psychosis (fep).201729173201
a systematic review and meta-analysis of lifestyle and body mass index predictors of successful assisted reproductive technologies.lifestyle (smoking, drinking alcohol) and body mass index (bmi) predictors of successful outcomes in assisted reproductive technology (art) treatments were examined in this meta-analysis.201729172958
cancer risk associated with nuclear atypia in cytologically indeterminate thyroid nodules: a systematic review and meta-analysis.indeterminate categories of thyroid cytopathology (categories b-iii and b-iv of the bethesda system) are integrated by a heterogeneous spectrum of cytological scenarios that are generally clustered for analysis and management recommendations. it has been suggested that aspirates exhibiting nuclear atypia have a higher risk of malignancy. this study aimed to assess whether cytologically indeterminate thyroid nodules with nuclear atypia have a significantly higher cancer risk than those without nu ...201729160163
mapping the association between vitamin d and low back pain: a systematic review and meta-analysis of observational studies.low back pain (lbp) is the highest contributor to disability worldwide, with current intervention strategies only providing small to moderate analgesic effects. the use of vitamin d supplementation for lbp has gained interest due to its proposed anti-inflammatory and neuromodulatory properties. however, it is still unclear whether vitamin d levels differ between those with and without lbp or if vitamin d levels are associated with pain intensity.201729149142
occupational noise exposure and the risk for work-related injury: a systematic review and meta-analysis.occupational noise exposure has been linked to work-related injuries. strategies to control occupational hazards often rely on dose-response relationships needed to inform policy, but quantitative synthesis of the relevant literature has not been done so far. this study aimed to systematically review the epidemiological literature and to perform meta-analysis of the risk for work-related injury due to occupational noise exposure.201729136415
the quality of australian indigenous primary health care research focusing on social and emotional wellbeing: a systematic review.objectives and importance of the study: primary health care research focused on aboriginal and torres strait islander (indigenous) people is needed to ensure that key frontline services provide evidence based and culturally appropriate care. we systematically reviewed the published primary health care literature to identify research designs, processes and outcomes, and assess the scientific quality of research focused on social and emotional wellbeing. this will inform future research to improve ...201729114717
updating the "risk index": a systematic review and meta-analysis of occupational injuries and work schedule characteristics.fatigue is a major risk factor for occupational 'accidents' and injuries, and involves dimensions of physical, mental, and muscular fatigue. these dimensions are largely influenced by temporal aspects of work schedules. the "risk index" combines four fatigue-related components of work schedules to estimate occupational 'accident' and injury risk based on empirical trends: shift type (morning, afternoon/evening, night), length and consecutive number, and on-shift rest breaks. since its first intr ...201729064297
evidence for decreasing sperm count in african population from 1965 to 2015.this meta-analysis, following our previous reports those documented an overall 57% diminution in mean sperm concentration around the globe over past 35 years and 32.5% decline in past 50 years in european population, attempts to report the declining trend of sperm concentrations in african population between 1965 and 2015.201729062337
molecular taxonomy and subgeneric classification of tapeworms of the genus moniezia blanchard, 1891 (cestoda, anoplocephalidae) in northern cervids (alces and rangifer).phylogenetic relationships of tapeworms of the genus moniezia blanchard, 1891 (cestoda, anoplocephalidae) parasitizing the eurasian elk alces alces, the moose a. americanus and the reindeer/caribou rangifer tarandus (cervidae) were studied using dna sequences of two mitochondrial genes (cox1 and nad1). several isolates from domestic ruminants, representing moniezia expansa (rudolphi, 1810) sensu lato and m. benedeni (moniez, 1879) sensu lato, and one unidentified isolate from an african antelope ...201729288139
experimental life-cycle of varestrongylus eleguneniensis (nematoda: protostrongylidae) in a captive reindeer (rangifer tarandus tarandus) and a muskox (ovibos moschatus moschatus).the life-cycle of a recently described protostrongylid lungworm, varestrongylus eleguneniensis, which infects caribou, muskoxen, and moose from arctic and boreal regions of north america, was completed experimentally for the first time. a native north american slug species, deroceras laeve, was infected with the first-stage larvae (l1) isolated from the feces of wild muskoxen to generate third-stage larvae (l3). these were administered to a captive reindeer calf (250 l3) and an adult captive mus ...201728590168
climate warming is associated with smaller body size and shorter lifespans in moose near their southern range limit.despite the importance of body size for individual fitness, population dynamics and community dynamics, the influence of climate change on growth and body size is inadequately understood, particularly for long-lived vertebrates. although temporal trends in body size have been documented, it remains unclear whether these changes represent the adverse impact of climate change (environmental stress constraining phenotypes) or its mitigation (via phenotypic plasticity or evolution). concerns have al ...201729226555
spatio-temporal trends in crop damage inform recent climate-mediated expansion of a large boreal herbivore into an agro-ecosystem.large-scale climatic fluctuations have caused species range shifts. moose (alces alces) have expanded their range southward into agricultural areas previously not considered moose habitat. we found that moose expansion into agro-ecosystems is mediated by broad-scale climatic factors and access to high-quality forage (i.e., crops). we used crop damage records to quantify moose presence across the canadian prairies. we regressed latitude of crop damage against north atlantic oscillation (nao) and ...201729123188
state-dependent behavior alters endocrine-energy relationship: implications for conservation and management.glucocorticoids (gc) and triiodothyronine (t3) are two endocrine markers commonly used to quantify resource limitation, yet the relationships between these markers and the energetic state of animals has been studied primarily in small-bodied species in captivity. free-ranging animals, however, adjust energy intake in accordance with their energy reserves, a behavior known as state-dependent foraging. further, links between life-history strategies and metabolic allometries cause energy intake and ...201728777884
ninety-nine de novo assembled genomes from the moose (alces alces) rumen microbiome provide new insights into microbial plant biomass degradation.the moose (alces alces) is a ruminant that harvests energy from fiber-rich lignocellulose material through carbohydrate-active enzymes (cazymes) produced by its rumen microbes. we applied shotgun metagenomics to rumen contents from six moose to obtain insights into this microbiome. following binning, 99 metagenome-assembled genomes (mags) belonging to 11 prokaryotic phyla were reconstructed and characterized based on phylogeny and cazyme profile. the taxonomy of these mags reflected the overall ...201728731473
decline of heterozygosity in a large but isolated population: a 45-year examination of moose genetic diversity on isle royale.wildlife conservation and management approaches typically focus on demographic measurements to assess population viability over both short and long periods. however, genetic diversity is an important predictor of long term population vitality. we investigated the pattern of change in genetic diversity in a large and likely isolated moose (alces alces) population on isle royale (lake superior) from 1960-2005. we characterized samples, partitioned into five different 5-year periods, using nine mic ...201728729957
outcome of intracerebral haemorrhage related to non-vitamin k antagonists oral anticoagulants versus vitamin k antagonists: a comprehensive systematic review and meta-analysis.the characteristics and natural history of acute non-vitamin k antagonists oral anticoagulants (noac)-associated intracerebral haemorrhage (ich) are largely unknown. we performed a comprehensive systematic review and meta-analysis to compare baseline ich volume, haematoma expansion and clinical outcomes between noac-ich versus vitamin k antagonists-ich (vka-ich).201729030422
stoichiometric distribution models: ecological stoichiometry at the landscape extent.human activities are altering the fundamental geography of biogeochemicals. yet we lack an understanding of how the spatial patterns in organismal stoichiometry affect biogeochemical processes and the tools to predict the impacts of global changes on biogeochemical processes. in this contribution we develop stoichiometric distribution models (stdms), which allow us to map spatial structure in resource elemental composition across a landscape and evaluate spatial responses of consumers. we parame ...201729027338
the value of lncrna neat1 as a prognostic factor for survival of cancer outcome: a meta-analysis.the present meta-analysis aimed to analyze available data to identify the prognostic role of neat1 in multiple carcinomas. a systematic search was performed by using several computerized databases from inception to june 7, 2017. the quantity of the publications was assessed according to moose checklist. pooled hrs with 95% ci was calculated to summarize the effect. a total of 12 studies with 3,262 cancer patients were pooled in the analysis to evaluate the prognostic value of neat1 in multiple t ...201729026116
does caesarean section affect breastfeeding practices in china? a systematic review and meta-analysis.objectives to ascertain the association between caesarean delivery and breastfeeding practices in china. methods we conducted a systematic review and meta-analysis following the preferred reporting items for systematic reviews and meta-analyses (prisma) and meta-analysis of observational studies in epidemiology (moose) guidelines. electronic databases of cnki, medline, embase, cinahl, proquest and science direct were searched and screened to identify relevant articles from january 1990 to june 2 ...201729019000
inflammatory bowel disease and eating disorders: a systematized review of comorbidity.research has shown that there is an association between inflammatory bowel disease, anxiety and mood disorders, however little is known about their association with eating disorders. in this paper we will present a case of a young female with a comorbid diagnosis of inflammatory bowel disease and eating disorder, and then discuss the results from a systematic review of the literature, describing published cases of patients with the same condition.201728992897
association of krouse classification for sinonasal inverted papilloma with recurrence: a systematic review and meta-analysis.the risk factors for the recurrence of sinonasal inverted papilloma are still unclear.201728973390
long-term survival of women with breast cancer. overview supportive care needs assessment instruments.worldwide, breast cancer is the fifth leading cause of cancer death (after lung, stomach, liver and colon cancer), while among women it is first on the list. the incidence of breast cancer has made a dramatic increase since 1970 which is partly interpreted by the modern western life standards. the expected risk of breast cancer throughout a lifespan of an average is 1 in 11 women. the five-year survival rates for breast cancer are at 80% if it has not spread, and only at 40% for the metastatic t ...201728971436
the accuracy of the broselow tape as a weight estimation tool and a drug-dosing guide - a systematic review and meta-analysis.the broselow tape is widely used as a weight-estimation device and drug-dosing guide aid, but concerns about its accuracy and its efficacy have emerged in the last decade. the aim of this study was to systematically review the literature to analyse the accuracy of the broselow tape as a weight estimation device and review evidence of its utility as a drug-dosing guide.201728958796
modelling time to population extinction when individual reproduction is autocorrelated.in nature, individual reproductive success is seldom independent from year to year, due to factors such as reproductive costs and individual heterogeneity. however, population projection models that incorporate temporal autocorrelations in individual reproduction can be difficult to parameterise, particularly when data are sparse. we therefore examine whether such models are necessary to avoid biased estimates of stochastic population growth and extinction risk, by comparing output from a matrix ...201728925038
the use of the model of occupational self efficacy in improving the cognitive functioning of individuals with brain injury: a pre- and post-intervention study.individuals diagnosed with a traumatic brain injury (tbi) often experience major limitations in returning to work despite participating in rehabilitation programmes.201728922182
immunomodulatory treatments for persistent and chronic immune thrombocytopenic purpura: a prisma-compliant systematic review and meta-analysis of 28 studies.corticosteroid sparing is required in 15% to 40% of adults with persistent or chronic primary immune thrombocytopenic purpura (itp). herein, the efficacy of immunomodulatory drugs (dapsone, interferon alpha, danazol, and hydroxychloroquine as second-third-line therapies in itp is investigated.201728906353
association between mdm2 snp309, p53 arg72pro, and hepatocellular carcinoma risk: a moose-compliant meta-analysis.epidemiological studies have determined the associations between polymorphisms on the promoter of mdm2 (snp309) and the codon 72 on exon 4 of p53 (p53 arg72pro) and the risk of hepatocellular carcinoma (hcc); however, the results were not always consistent. the aim of the present meta-analysis was to evaluate the overall associations between these 2 variants and hcc risk.the medline, web of science, embase, cochrane library, and cnki databases were searched for eligibility studies and the data w ...201728885338
diabetes and pressure ulcer risk in hip fracture patients: a meta-analysis.the aim of this study was to assess the relationship between diabetes and pressure ulcer (pu) risk in patients with hip fractures.201728880760
rna-sequence data normalization through in silico prediction of reference genes: the bacterial response to dna damage as case study.measuring how gene expression changes in the course of an experiment assesses how an organism responds on a molecular level. sequencing of rna molecules, and their subsequent quantification, aims to assess global gene expression changes on the rna level (transcriptome). while advances in high-throughput rna-sequencing (rna-seq) technologies allow for inexpensive data generation, accurate post-processing and normalization across samples is required to eliminate any systematic noise introduced by ...201728878825
association of sleep-disordered breathing with cognitive function and risk of cognitive impairment: a systematic review and meta-analysis.growing evidence suggests an association between sleep-disordered breathing (sdb) and cognitive decline in elderly persons. however, results from population-based studies have been conflicting, possibly owing to different methods to assess sdb or cognitive domains, making it difficult to draw conclusions on this association.201728846764
hypofractionated radiation therapy for basal and squamous cell skin cancer: a meta-analysis.to characterize the cosmetic outcomes and local recurrence (lr) rates of various hypofractionated radiation therapy (rt) regimens for skin basal and squamous cell cancers (bccs/sccs).201728843727
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