Publications

curcumin activates ampk and suppresses gluconeogenic gene expression in hepatoma cells.	curcumin, the bioactive component of curry spice turmeric, and its related structures possess potent anti-oxidant and anti-inflammatory properties. several lines of evidence suggest that curcumin may play a beneficial role in animal models of diabetes, both by lowering blood glucose levels and by ameliorating the long-term complications of diabetes. however, current understanding of the mechanism of curcumin action is rudimentary and is limited to its anti-oxidant and anti-inflammatory effects. ...	2009	19665995
curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible nf-kappab activity.	radiation therapy is an integral part of the preoperative treatment of rectal cancers. however, only a minority of patients achieve a complete pathologic response to therapy because of resistance of these tumors to radiation therapy. this resistance may be mediated by constitutively active pro-survival signaling pathways or by inducible/acquired mechanisms in response to radiation therapy. simultaneous inhibition of these pathways can sensitize these tumors to radiation therapy.	2009	19735878
antihyperglycemic, antihyperlipidemic and antioxidant effects of dihar, a polyherbal ayurvedic formulation in streptozotocin induced diabetic rats.	present investigation was undertaken to evaluate antihyperglycemic, antihyperlipidemic and antioxidant activities of dihar, a polyherbal formulation containing drugs from eight different herbs viz., syzygium cumini, momordica charantia, emblica officinalis, gymnema sylvestre, enicostemma littorale, azadirachta indica, tinospora cordifolia and curcuma longa in streptozotocin (stz, 45 mg/kg iv single dose) induced type 1 diabetic rats. stz produced a significant increase in serum glucose, choleste ...	2009	19761040
activation of muscarinic m-1 cholinoceptors by curcumin to increase glucose uptake into skeletal muscle isolated from wistar rats.	curcumin, an active principle contained in rhizome of curcuma longa, has been mentioned to show merit for diabetes through its anti-oxidative and anti-inflammatory properties. in the present study, we found that curcumin caused a concentration-dependent increase of glucose uptake into skeletal muscle isolated from wistar rats. this action was inhibited by pirenzepine at concentration enough to block muscarinic m-1 cholinoceptor (m(1)-machr). in radioligand binding assay, the binding of [(3)h]-pi ...	2009	19765405
stability of lipid constituents in radiation processed fenugreek seeds and turmeric: role of phenolic antioxidants.	impact of radiation processing on the lipid profile of fenugreek and turmeric was investigated. oleic and linoleic acid were the dominant fatty acids with an appreciable amount of linolenic acid in both cases. gamma-irradiation did not bring about any significant changes in the fatty acid profile of these spices despite a high content of unsaturation. the ability of aqueous methanolic extract of both spices with high phenolic content to prevent lipid peroxidation suggests a possible role of phen ...	2009	19769367
safety and toxicological evaluation of demethylatedcurcuminoids; a novel standardized curcumin product.	turmeric is a well recognized and highly recommended herb in ayurvedic systems of medicine and it has also been used for culinary purposes for thousands of years. bis-o-demethylatedcurcumin (bdmc) was found to be more efficacious than curcumin and the increased potentcy was attributed to a higher number of phenolic groups in bdmc. a novel demethylatedcurcuminoid composition (dc) comprising minimum 95% of total demethylatedcurcuminoids (67.8% bisdemethylcurcumin, 20.7% demethylmonodemethoxycurcum ...	2009	19778247
an anticancer effect of curcumin mediated by down-regulating phosphatase of regenerating liver-3 expression on highly metastatic melanoma cells.	phosphatase of regenerating liver-3 (prl-3) has been suggested as a potential target for anticancer drugs based on its involvement in tumor metastasis. however, little is known about a small-molecule inhibitor against prl-3. in this study, we report that curcumin, the component of the spice turmeric, shows its antitumor effect by selectively down-regulating the expression of prl-3 but not its family members prl-1 and -2 in a p53-independent way. curcumin inhibited the phosphorylation of src and ...	2009	19779032
the role of curcuma longa against doxorubicin (adriamycin)-induced toxicity in rats.	the major component, called curcumin, of turmeric (curcuma longa l.) (family zingiberaceae) powder is responsible for its biological actions. the present study aimed to prove the protective effect of turmeric extract against doxorubicin (dox)-induced cardiac, hepatic, and renal toxicity as evaluated in rats. body weight and urine volume of the animal groups under investigation were recorded daily throughout the experimental period. also, the cardiac, hepatic, and renal toxicities were determined ...	2009	19459743
partially purified curcuma longa inhibits alpha-melanocyte-stimulating hormone-stimulated melanogenesis through extracellular signal-regulated kinase or akt activation-mediated signalling in b16f10 cells.	bioassay-guided fractionation of curcuma longa by solvent partitioning and purification with octadecylsilane open column chromatography yielded a partial purification. the active 80% methanol chromatographic fraction from the ethyl acetate layer [partial purification from c. longa (ppc)] was used to investigate the alpha-melanocyte-stimulating hormone (alpha-msh)-stimulated melanogenesis signal pathway in b16f10 cells. in cells stimulated alpha-msh, ppc inhibited cellular melanin contents, tyros ...	2009	19469902
curcumin modulates efflux mediated by yeast abc multidrug transporters and is synergistic with antifungals.	curcumin (cur), a natural product of turmeric, from rhizomes of curcuma longa, is a known agent of reversal of drug resistance phenotypes in cancer cells overexpressing atp-binding cassette (abc) transporters, viz., abcb1, abcg2, and abcc1. in the present study, we evaluated whether cur could also modulate multidrug transporters of yeasts that belong either to the abc family or to the major facilitator superfamily (mfs). the effect of cur on multidrug transporter proteins was demonstrated by exa ...	2009	19470507
in vitro screening for anthelmintic and antitumour activity of ethnomedicinal plants from thailand.	this study screened for anthelmintic and/or antitumour bioactive compounds from thai indigenous plants and evaluated effectiveness against three different worm species and two cancer cell lines.	2009	19473794
curcumin inhibits the migration and invasion of human a549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and -9 and vascular endothelial growth factor (vegf).	it is well known that matrix metalloproteinases (mmps) act an important role in the invasion, metastasis and angiogenesis of cancer cells. agents suppressed the mmps could inhibited the cancer cells migration and invasion. numerous evidences had shown that curcumin (the active constituent of the dietary spice turmeric) has potential for the prevention and therapy of cancer. curcumin can inhibit the formation of tumors in animal models of carcinogenesis and act on a variety of molecular targets i ...	2009	19477063
hypotensive and endothelium-independent vasorelaxant effects of methanolic extract from curcuma longa l. in rats.	curcuma longa l. (cl) is a yellow rhizome that is used in african traditional medicine to treat palpitation, hypertension or other related blood circulation disorders.	2009	19481144
nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer.	curcumin, a derived product from common spice turmeric that is safe and beneficial in several aliments was formulated into biodegradable nanoparticles with a view to improve its oral bioavailability. the curcumin encapsulated nanoparticles prepared by emulsion technique were spherical in shape with particle size of 264nm (polydispersity index 0.31) and 76.9% entrapment at 15% loading. the curcumin encapsulated nanoparticles were able to withstand the international conference on harmonisation (ic ...	2009	19491009
analysis of binding interaction of curcumin and diacetylcurcumin with human and bovine serum albumin using fluorescence and circular dichroism spectroscopy.	the current study reports the binding of curcumin (cur) as the main pharmacologically active ingredient of turmeric and diacetylcurcumin (dac) as a bioactive derivative of curcumin to human serum albumin (hsa) and bovine serum albumin (bsa). the apparent binding constants and number of substantive binding sites have been evaluated by fluorescence quenching method. the distance (r) between donor (hsa and bsa) and acceptor (cur and dac) was obtained on the basis of the förster's theory of non-radi ...	2009	19495944
effects of curcumin for preventing restenosis in a hypercholesterolemic rabbit iliac artery stent model.	to evaluate the efficacy of the curcumin-coating stent (ccs) on the inhibition of restenosis in a rabbit iliac artery stent model.	2009	19496118
curcumin induces apoptosis through fas and fadd, in caspase-3-dependent and -independent pathways in the n18 mouse-rat hybrid retina ganglion cells.	curcumin, a naturally occurring yellow pigment isolated from turmeric, is a well known antioxidant with broad spectrum of anti-tumor activities against many human cancer cells. in this study, curcumin-induced cytotoxic effect of mouse-rat hybrid retina ganglion cells (n18) were investigated. for determining cell viability, the trypan blue exclusion and flow cytometric analysis were used. the curcumin-caused cell cycle arrest in n18 cells was examined by flow cytometry. curcumin affect on the pro ...	2009	19513510
curcumin has bright prospects for the treatment of inflammatory bowel disease.	inflammatory bowel disease (ibd) is a chronic relapsing-remitting condition that afflicts millions of people throughout the world and impairs their daily functions and quality of life. while the aetiology of ibd is not understood well, it appears to be driven by inflammatory cytokines such as tumor necrosis factor (tnf)-alpha. hence, there is a strong interest in agents that can block the generation or actions of inflammatory cytokines. curcumin is a bioactive substance present in the rhizomes o ...	2009	19519446
curcumin inhibits cell proliferation of mda-mb-231 and bt-483 breast cancer cells mediated by down-regulation of nfkappab, cyclind and mmp-1 transcription.	curcumin, an active constituent of turmeric, has been shown to possess inhibitory effect of cell proliferation and induction of apoptosis towards a board range of tumors. cell inhibition activities of curcumin are behaved differently in various cell types. to investigate the mechanism basis for the cell inhibition of curcumin on breast cancer cell lines, we examine curcumin effect on nfkappab, cell cycle regulatory proteins and matrix metalloproteinases (mmps) in two breast cancer cell lines (md ...	2009	19524420
determination of minimum effective dose and optimal dosing schedule for liposomal curcumin in a xenograft human pancreatic cancer model.	curcumin is a food chemical present in tumeric (curcuma longa) that has pharmacological activity to suppress carcinogenesis and inhibits multiple signaling pathways such as nuclear factor kappab (nf-kappab), cyclooxygenase-2 (cox-2) and interleukin-8 (il-8). oral curcumin has poor oral bioavailability limiting its clinical activity; however, a patent pending liposomal formulation of curcumin was developed to improve drug delivery and has demonstrated activity in multiple cancers. this study was ...	2009	19528445
photostability of natural orange-red and yellow fungal pigments in liquid food model systems.	the variation in the photostability among the currently authorized natural pigments limits their application span to a certain type of food system, and more robust alternatives are being sought after to overcome this problem. in the present study, the photostability of an orange-red and a yellow fungal pigment extract produced by ascomycetous fungi belonging to the genera penicillium and epicoccum , respectively, were studied in a soft drink model medium and in citrate buffer at low and neutral ...	2009	19534525
amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of il-17 production.	experimental autoimmune encephalomylitis (eae), an animal mode of multiple sclerosis (ms), was previously considered that be mediated by th1 cells. however, a number of recent studies provided strong evidence that t helper cells that produce il-17 play a dominant role in the pathogenesis of eae. curcumin (1,7-bis 94-hydroxy-3-methoxyphenyl)-1,6 heptadiene-3, 5-di-one) is a naturally occurring polyphenolic phytochemical isolated from the rhizome of the medicinal plant curcuma longa. it has been s ...	2009	19539560
curcumin improves vascular function and alleviates oxidative stress in non-lethal lipopolysaccharide-induced endotoxaemia in mice.	oxidative stress is implicated in various pathological conditions, including septic shock, and other diseases associated with local or systemic inflammation. curcumin, a major component from turmeric (curcuma longa), possesses diverse anti-inflammatory, anti-tumour and antioxidant properties. the aim of this study was to investigate the effect of curcumin on modulation of vascular dysfunction and oxidative stress induced by lipopolysaccharide (lps) in mice. male icr mice were treated with curcum ...	2009	19540224
curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress.	chronic stress occurs in everyday life and induces impaired spatial cognition, neuroendocrine and plasticity abnormalities. a potential therapeutic for these stress related disturbances is curcumin, derived from the curry spice turmeric. previously we demonstrated that curcumin reversed the chronic stress-induced behavioral deficits in escape from an aversive stimulus, however the mechanism behind its beneficial effects on stress-induced learning defects and associated pathologies are unknown. t ...	2009	19540859
effects of a turmeric extract (curcuma longa) on chronic ultraviolet b irradiation-induced skin damage in melanin-possessing hairless mice.	turmeric (the rhizomes of curcuma longa l., zingiberacease) is widely used as a dietary pigment and spice, and has been traditionally used for the treatment of inflammation, skin wounds and hepatic disorders in ayurvedic, unani and chinese medicine. although the topical application or oral administration of turmeric is used to improve skin trouble, there is no evidence to support this effect. the aim of this study was to clarify whether turmeric prevents chronic ultraviolet b (uvb)-irradiated sk ...	2009	19577913
curcumin derivatives: molecular basis of their anti-cancer activity.	curcumin, a phenolic compound from the plant curcuma longa l., has shown a wide-spectrum of chemopreventive, antioxidant and antitumor properties. although its promising chemotherapeutic activity, preclinical and clinical studies highlight curcumin limited therapeutic application due to its instability in physiological conditions. to improve its stability and activity, many derivatives have been synthesized and studied, among which bis-demethoxycurcumin (bdmc) and diacetylcurcumin (dac). in this ...	2009	19580791
curcumin suppresses expression of low-density lipoprotein (ldl) receptor, leading to the inhibition of ldl-induced activation of hepatic stellate cells.	obesity is often accompanied by hypercholesterolemia characterized by elevated levels of plasma low-density lipoprotein (ldl) and associated with non-alcoholic steatohepatitis, which could progress to hepatic fibrosis. hepatic stellate cells (hscs) are the major effectors of hepatic fibrogenesis. this study aims to clarify effects of ldl on activation of hsc, to evaluate roles of curcumin in suppressing these effects and to further elucidate the underlying molecular mechanisms. experimental appr ...	2009	19594758
protective effect of curcumin (curcuma longa), against aluminium toxicity: possible behavioral and biochemical alterations in rats.	aluminium is a potent neurotoxin and has been associated with alzheimer's disease (ad) causality for decades. prolonged aluminium exposure induces oxidative stress and increases amyloid beta levels in vivo. current treatment modalities for ad provide only symptomatic relief thus necessitating the development of new drugs with fewer side effects. the aim of the study was to demonstrate the protective effect of chronic curcumin administration against aluminium-induced cognitive dysfunction and oxi ...	2009	19616038
innate immune response and disease resistance in carassius auratus by triherbal solvent extracts.	this study reports the effect of aqueous, ethanol and methanol triherbal solvent extract from azadirachta indica, ocimum sanctum and curcuma longa on innate immune mechanisms such as phagocytosis activity, respiratory burst activity, alternative complement activity and lysozyme activity and disease resistance in goldfish (carassius auratus) against aeromonas hydrophila. fish were intraperitoneally injected with different doses of 0, 5, 50 and 100 mg kg(-1) body weight of each triherbal solvent e ...	2009	19616631
curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin d1, cox-2, mmp-9, vegf and cxcr4 expression in an orthotopic mouse model.	because of the poor prognosis and the development of resistance against chemotherapeutic drugs, the current treatment for advanced metastatic colorectal cancer (crc) is ineffective. whether curcumin (a component of turmeric) can potentiate the effect of capecitabine against growth and metastasis of crc was investigated. the effect of curcumin on proliferation of crc cell lines was examined by mitochondrial dye-uptake assay, apoptosis by esterase staining, nuclear factor-kappab (nf-kappab) by ele ...	2009	19623659
curcumin analogues exhibit enhanced growth suppressive activity in human pancreatic cancer cells.	curcumin, a yellow pigment and the active component of turmeric, has been shown to protect against carcinogenesis and prevent tumor development in several types of cancer. however, its low bioavailability and potency prevent it from being effective in most chemotherapeutic applications. one potential means of circumventing this problem has been the creation of synthetic curcumin analogues. we tested the efficacy of two such analogues, known as flll11 and flll12, in human pancreatic cancer cell l ...	2009	19384191
effects of curcuminoid supplement on cardiac autonomic status in high-fat-induced obese rats.	sudden cardiac death in obesity is frequently associated with sympathetic activation due to an elevated plasma free-fatty acid (ffa) level. curcuminoids, the phenolic yellowish pigments of turmeric, display antioxidative and lipid-lowering activities. we hypothesized that curcuminoids ameliorate cardiac sympathovagal disturbance in high-fat-induced obese rats.	2009	19398300
antiviral effect of curcuma longa linn extract against hepatitis b virus replication.	a medicinal herb curcuma longa linn has been used for treating various liver diseases caused by hepatitis b virus (hbv) in asia.	2009	19409970
demethoxycurcumin induces bcl-2 mediated g2/m arrest and apoptosis in human glioma u87 cells.	docking analysis of curcumin (c1), demethoxycurcumin (c2) and bisdemethoxycurcumin (c3) with bcl-2 illustrated that among the three curcuminoids, c2 binds more efficiently into its putative active site. c1, c2 and c3 were purified from turmeric rhizomes to demonstrate the molecular mechanism of their anticancer activity on human glioma u87 cells. human glioma u87 cells treated with curcuminoids resulted in activation of bcl-2 mediated g2 checkpoint, which was associated with the induction of g2/ ...	2009	19422808
curcumin protects neuronal cells from japanese encephalitis virus-mediated cell death and also inhibits infective viral particle formation by dysregulation of ubiquitin-proteasome system.	japanese encephalitis (je) is an arboviral disease common in southeast asia encompassing a population of 3 billion people. periodic outbreak of je takes hundreds of lives. children are major victims of je. about one third of je patients die, and many of the survivors suffer from permanent neuropsychiatric sequel, owing to the lack of specific therapeutic measure. curcumin is a naturally occurring phenolic compound extracted from curcuma longa l. previous studies have reported that curcumin posse ...	2009	19434500
bubbling hookah smoke through heat-solubilized curcumin/turmeric and incorporation of the curry spice as an additive or filter in cigarettes to minimize tobacco smoke-related toxicants.		2009	19435657
reversible antifertility effect of aqueous rhizome extract of curcuma longa l. in male laboratory mice.	the purpose of the present study was to evaluate the antifertility potential of curcuma longa l. in the male laboratory mouse.	2009	19442785
amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of alzheimer's type (sdat).	recent evidence indicates that curcumin (cur), the principal curcuminoid of turmeric, exhibits antioxidant potential and protects the brain against various oxidative stressors. the aim of the present study was to examine the modulating impacts of cur against cognitive deficits and oxidative damage in intracerebroventricular-streptozotocin (icv-stz) infused rats. rats were injected bilaterally with icv-stz (3 mg/kg), while sham rats received the same volume of vehicle and then supplemented with c ...	2009	19329286
curcumin synergizes the growth inhibitory properties of indian toad (bufo melanostictus schneider) skin-derived factor (bm-anf1) in hct-116 colon cancer cells.	curcumin, an active ingredient of turmeric with no discernable toxicity, inhibits the growth of transformed cells and the development and progression of colon carcinogenesis in experimental animals. recent data from one of our laboratories demonstrated that a crude skin extract or a purified crystalline compound (bufo melanostictus-antineoplastic factor 1, bm-anf1) from indian common toad (bufo melanostictus, schneider) skin inhibits the growth of human leukemic cells. the present investigation ...	2009	19331178
new structural analogues of curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cells.	colorectal carcinoma is one of the major causes of morbidity and mortality in the western world. novel therapeutic approaches are needed for colorectal carcinoma. curcumin, the active component and yellow pigment of turmeric, has been reported to have several anti-cancer activities including anti-proliferation, anti-invasion, and anti-angiogenesis. clinical trials have suggested that curcumin may serve as a potential preventive or therapeutic agent for colorectal cancer.	2009	19331692
systematic review of the management of canine osteoarthritis.	this review assesses the evidence for the efficacy of therapies used in the management of osteoarthritis in dogs on the basis of papers published in peer-reviewed journals in english between 1985 and july 2007. sixty-eight papers were identified and evaluated. they considered four alternative therapies, one use of functional food, two intra-articular agents, six nutraceutical agents, 21 pharmacological agents, two physical therapies, three surgical techniques and two combinations of weight contr ...	2009	19346540
curcumin binding to dna and rna.	curcumin, the yellow pigment from the rhizoma of curcuma longa, is a widely studied phytochemical with a variety of biological activities. the ongoing research and clinical trials have proved that this natural phenolic compound has great and diverse pharmacological potencies. beside its effective antioxidant, antiinflammatory, and antimicrobial/antiviral properties, curcumin is also considered as a cancer chemopreventive agent. while the antioxidant activity of curcumin is well documented, its i ...	2009	19364279
curcumin blocks brain tumor formation.	turmeric, an essential ingredient of culinary preparations of southeast asia, contains a major polyphenolic compound, named curcumin or diferuloylmethane, which eliminates cancer cells derived from a variety of peripheral tissues. although in vitro experiments have addressed its anti-tumor property, no in vivo studies have explored its anti-cancer activity in the brain. oral delivery of this food component has been less effective because of its low solubility in water. we show that a soluble for ...	2009	19368804
curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model.	curcumin (diferuloylmethane), a yellow pigment in turmeric, has been shown to inhibit the activation of nuclear factor-kappab (nf-kappab), a transcription factor closely linked to chemoresistance in multiple myeloma cells. whether curcumin can overcome chemoresistance and enhance the activity of thalidomide and bortezomib, used to treat patients with multiple myeloma, was investigated in vitro and in xenograft model in nude mice. our results show that curcumin inhibited the proliferation of huma ...	2009	19372569
curcumin arrests endometriosis by downregulation of matrix metalloproteinase-9 activity.	curcumin, a polyphenol derived from turmeric (curcuma longa) possesses diverse pharmacological properties including antioxidant, anti-inflammatory and antiproliferative activities. endometriosis is a gyneocological disorder characterized by growth of endometrial tissues outside uterus that involves aberrant matrix remodeling. in this study the effect of curcumin was studied on surgically developed endometriosis in mice. endometriosis with varying severity was developed in mice by peritoneal impl ...	2009	19374255
curcumin attenuates aluminium-induced functional neurotoxicity in rats.	curcumin is a polyphenol extracted from the rhizome of curcuma longa and well known as a multi-functional drug with antioxidative, anti-cancerous and anti-inflammatory activities. curcumin's antiaging and neuroprotective potential is widely reported. in the present study, effect of curcumin treatment dose 30 mg kg(-1) day(-1) was investigated against aluminium neurotoxicity in young and old animals. direct and indirect intakes of aluminium have been reported to be involved in the etiology of sev ...	2009	19376155
green tea, vitamins d and b, milk thistle, cranberries, and turmeric top list of ingredients ranked; call for methods issued.		2009	19382549
curcumin inhibits prosurvival pathways in chronic lymphocytic leukemia b cells and may overcome their stromal protection in combination with egcg.	chronic lymphocytic leukemia (cll) is incurable with current chemotherapy treatments. curcumin (diferuloylmethane), an active ingredient in the spice turmeric, inhibits tumor metastasis, invasion, and angiogenesis in tumor cell lines. we evaluated the effects of curcumin on the viability of primary cll b cells and its ability to overcome stromal mediated protection.	2009	19228728
the protective role of curcumin in cardiovascular diseases.	curcumin (diferuloylmethane) is a polyphenol responsible for the yellow color of the curry spice turmeric. it has been used in a variety of diseases in traditional medicine. modern scientific research has demonstrated its anti-inflammatory, anti-oxidant, anti-carcinogenic, anti-thrombotic, and cardiovascular protective effects. in this review, we focused mainly on the effects of curcumin on the cardiovascular system. the antioxidant effects of curcumin have been shown to attenuate adriamycin-ind ...	2009	19233493
immunomodulatory effects of curcumin treatment on murine schistosomiasis mansoni.	curcumin is a polyphenol derived from the dietary spice turmeric. it has been shown to regulate numerous transcription factors, cytokines, adhesion molecules, and enzymes that have been linked to inflammation. in addition to inhibiting the growth of a variety of pathogens, curcumin has been shown to have nematocidal activity. the present study was designed to evaluate the schistosomicidal activity of curcumin in vivo as well as immunomodulation of granulomatous inflammation and liver pathology i ...	2009	19249123
activation of apoptotic protein in u937 cells by a component of turmeric oil.	aromatic (ar)-turmerone from turmeric oil displays anti-tumorigenesis activity that includes inhibited cell proliferation. this study investigated ar-turmerone-mediated apoptotic protein activation in human lymphoma u937 cells. ar-turmerone treatment inhibited u937 cell viability in a concentration-dependent fashion, with inhibition exceeding 84%. moreover, the treatment produced nucleosomal dna fragmentation and the percentage of sub-diploid cells increased in a concentration-dependent manner; ...	2009	19250610
pharmacokinetics prediction and drugability assessment of diphenylheptanoids from turmeric (curcuma longa l).	cheminformatics approaches are currently not employed in any of the spices to study the medicinal properties traditionally attributed to them. the aim of this study is to find the most efficacious molecule which do not have toxic effects but at the same time have desired pharmacokinetic profile. in the present study of the class 'diphenylheptanoids' from turmeric, cheminformatics methods were employed to predict properties such as physicochemical properties, absorption, distribution, metabolism, ...	2009	19275711
further examination of antiradical properties of crocus sativus stigmas extract rich in crocins.	data for antiradical properties of saffron extract and its bioactive constituents (crocins, crocetin) are limited and poorly discussed in comparison with those of extracts containing potent scavengers. further examination was sought using the folin-ciocalteu (f-c) reagent and various free radical species produced in cell-free or cell model systems. oregano and turmeric methanol extracts, rich in well established scavengers, and also crocetin, rosmarinic acid, and curcumin, representing the major ...	2009	19284715
prophylactic role of curcumin in dextran sulfate sodium (dss)-induced ulcerative colitis murine model.	we have addressed in this study the possible protective role of the main principle of turmeric pigment; curcumin on a murine model of ulcerative colitis (uc). colitis was induced by administration of dextran sulfate sodium (dss) (3% w/v) in drinking water to male swiss albino rats for 5 consecutive days. dss challenge induced uc model that was well characterized morphologically and biochemically. dss produced shrinkage of colon length and increased the relative colon weight/length ratio accompan ...	2009	19285535
curcumin inhibits proliferation and migration by increasing the bax to bcl-2 ratio and decreasing nf-kappabp65 expression in breast cancer mda-mb-231 cells.	curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), is extracted from the plant curcuma longa. it has cytotoxic effects and induces apoptosis in many human cancer cells but the molecular mechanisms are not fully understood. in the present study, we evaluated the effects of curcumin on human breast cancer mda-mb-231 cells. the cytotoxic effects of curcumin on mda-mb-231 cells were measured by mtt assay. the percentages of cell cycle were determined by flow cytometry. the prote ...	2009	19288022
curcumin inhibits adipogenesis in 3t3-l1 adipocytes and angiogenesis and obesity in c57/bl mice.	angiogenesis is necessary for the growth of adipose tissue. dietary polyphenols may suppress growth of adipose tissue through their antiangiogenic activity and by modulating adipocyte metabolism. we investigated the effect of curcumin, the major polyphenol in turmeric spice, on angiogenesis, adipogenesis, differentiation, apoptosis, and gene expression involved in lipid and energy metabolism in 3t3-l1 adipocyte in cell culture systems and on body weight gain and adiposity in mice fed a high-fat ...	2009	19297423
curcumin eliminates leptin's effects on hepatic stellate cell activation via interrupting leptin signaling.	nonalcoholic steatohepatitis (nash) is commonly found in patients with obesity and is often accompanied with abnormally elevated levels of plasma leptin, i.e. hyperleptinemia. a relatively high population of nash patients develops hepatic fibrosis, even cirrhosis. hepatic stellate cells (hscs) are the major effector cells during liver fibrogenesis and could be activated by leptin. the antioxidant curcumin, a phytochemical from turmeric, has been shown to suppress hsc activation in vitro and in v ...	2009	19299451
antidepressant-like effects of curcumin on serotonergic receptor-coupled ac-camp pathway in chronic unpredictable mild stress of rats.	serotonergic receptors take their physiologic effects by affecting adenylyl cyclase (ac) catalytic activity and cyclic adenosine monophosphate (camp) concentration. ac-camp second messenger pathway has been recently suggested to play an important role in depression. therefore, the compound that regulates the signal pathway may have potential as antidepressant. curcumin is the main component of curcuma longa l, a well-known indigenous herb with comprehensive bioactivities. in the present study, w ...	2009	19302828
modulation of in vitro murine b-lymphocyte response by curcumin.	curcumin is a phenolic natural product isolated from the rhizome of curcuma longa (tumeric). it was previously described that curcumin had a potent anti-inflammatory effect and inhibited the proliferation of a variety of tumor cells. in the present study, we investigated the inhibitory effects of curcumin on the response of normal murine splenic b cells. curcumin inhibited the proliferative response of purified splenic b cells from balb/c mice stimulated with the toll-like receptor ligands lps a ...	2009	19303754
interaction of tea catechin (-)-epigallocatechin gallate with lipid bilayers.	a major component of green tea extracts, catechin (-)-epigallocatechin gallate (egcg), has been reported to be biologically active and interacting with membranes. a recent study reported drastic effects of egcg on giant unilamellar vesicles (guvs). in particular, egcg above 30 microm caused guvs to burst. here we investigated the effect of egcg on single guvs at lower concentrations, believing that its molecular mechanism would be more clearly revealed. we used the micropipette aspiration method ...	2009	19186140
comparative antiulcer effect of bisdemethoxycurcumin and curcumin in a gastric ulcer model system.	the antiulcer effect of bisdemethoxycurcumin, a yellow pigment found mainly in rhizomes of curcuma longa, was compared with curcumin in gastric ulcer model systems to validate its clinical application as a remedy for peptic ulcer. western blot analysis of mouse macrophage cell line raw 264.7 activated with lipopolysaccharide showed that bisdemethoxycurcumin inhibited inducible nitric oxide synthase (inos) production significantly but had no effect on tumor necrosis factor-alpha (tnf-alpha) produ ...	2009	19188055
molecular mechanism of curcumin induced cytotoxicity in human cervical carcinoma cells.	cervical cancer is the most common cancer in indian females and is associated with infection with high risk human papillomaviruses (hpvs). curcumin (diferuloyl methane), a chemopreventive agent, is a natural compound extracted from curcuma longa that allows suppression of carcinogenesis. the objective of this study was to identify the molecular mechanism of curcumin induced apoptosis in hpv positive cervical cancer hela, siha and ca ski cells. curcumin causes distinct inhibition of human telomer ...	2009	19191010
study on antifibrotic effects of curcumin in rat hepatic stellate cells.	suppression of activation or fibrogenesis and induction of apoptosis, in hepatic stellate cells (hscs) have been proposed as therapeutic strategies against liver fibrosis. curcumin, an active compound isolated from yellow curry pigment of turmeric (curcuma longa linn), has been demonstrated to be an effective anti-inflammatory and antioxidant compound. in this study, we investigated the in vitro antifibrogenic effects of curcumin on hscs at the concentration range of (1-40 microm). a cell line o ...	2009	19152370
curcumin attenuates oxidative damage in animals treated with a renal carcinogen, ferric nitrilotriacetate (fe-nta): implications for cancer prevention.	curcumin (diferuloylmethane), a biologically active ingredient derived from rhizome of the plant curcuma longa, has potent anticancer properties as demonstrated in a plethora of human cancer cell lines/animal carcinogenesis model and also acts as a biological response modifier in various disorders. we have reported previously that dietary supplementation of curcumin suppresses renal ornithine decarboxylase (okazaki et al. biochim biophys acta 1740:357-366, 2005) and enhances activities of antiox ...	2009	19165575
curcumin attenuates elastase- and cigarette smoke-induced pulmonary emphysema in mice.	curcumin, a yellow pigment obtained from turmeric (curcumina longa), is a dietary polyphenol that has been reported to possess anti-inflammatory and antioxidant properties. the effect of curcumin against the development of pulmonary emphysema in animal models is unknown. the aim of this study was to determine whether curcumin is able to attenuate the development of pulmonary emphysema in mice. nine-week-old male c57bl/6j mice were treated with intratracheal porcine pancreatic elastase (ppe) or e ...	2009	19168576
curcumin disrupts the mammalian target of rapamycin-raptor complex.	curcumin (diferuloylmethane), a polyphenol natural product of the plant curcuma longa, is undergoing early clinical trials as a novel anticancer agent. however, the anticancer mechanism of curcumin remains to be elucidated. recently, we have shown that curcumin inhibits phosphorylation of p70 s6 kinase 1 (s6k1) and eukaryotic initiation factor 4e (eif4e) binding protein 1 (4e-bp1), two downstream effector molecules of the mammalian target of rapamycin complex 1 (mtorc1) in numerous cancer cell l ...	2009	19176385
curcumin induces cell cycle arrest and apoptosis in human osteosarcoma (hos) cells.	curcumin is a major component of curcuma longa rhizome and has been used as a traditional medicine for centuries. in this study, we showed that curcumin induced cell cycle arrest followed by antiproliferation and apoptosis in human osteosarcoma (hos) cells.	2009	20044614
interaction of alphas1-casein with curcumin and its biological implications.	alpha(s1)-casein is one of the major protein components of the casein fraction of milk. curcumin (diferuloyl methane), the major curcuminoid, constituting about 2-5% of turmeric (curcuma longa ) is the active ingredient with many physiological, biochemical, and pharmacological properties. on the basis of spectroscopic measurements, it is inferred that curcumin binds to alpha(s1)-casein at ph 7.4 and 27 degrees c with two binding sites, one with high affinity [(2.01 +/- 0.6) x 10(6) m(-1)] and th ...	2009	19831420
curcumin attenuates the effects of insulin on stimulating hepatic stellate cell activation by interrupting insulin signaling and attenuating oxidative stress.	hyperinsulinemia associated with type ii diabetes mellitus (t2dm) is a risk factor for non-alcoholic steatohepatitis (nash) and hepatic fibrosis. hepatic stellate cells (hscs) are the major effectors in collagen production during hepatic fibrogenesis. elevated levels of insulin stimulate hsc activation. in addition to its anti-diabetic effects, the antioxidant curcumin, the yellow pigment in curry from turmeric, suppresses hsc activation and protects the liver from fibrogenesis in vitro and in v ...	2009	19841616
effects of curcumin in an orthotopic murine bladder tumor model.	cigarette smoking (cs) is the main risk factor for bladder cancer development. there are more than 100 carcinogens present in cigarette smoke. among the potential mediators of cs-induced alterations is nuclear factor-kappa (nf-kappab), which is responsible for the transcription of genes related to cell transformation, tumor promotion, angiogenesis, invasion and metastasis. curcumin is a polyphenol compound derived from curcuma longa that suppress cellular transformation, proliferation, invasion, ...	2009	19860939
[preliminary research on the mechanism of apoptosis hepatic stellate cells induced by zedoary turmeric oil].		2009	19874700
possibility of fighting food borne bacteria by egyptian folk medicinal herbs and spices extracts.	phytotherapy (herbal medicine) have a long-standing history in egypt. current study investigated the antimicrobial potentialities of twenty five herbs and spices which are widely used in folk medicine by egyptian housewives to treat gastrointestinal disorders against seven bacterial strains, mostly food borne including pathogens. they were tested by using paper disc diffusion technique as qualitative assay and agar dilution method for determining the minimum inhibitory concentration (mic) of her ...	2009	19712651
optimized turmeric extracts have potent anti-amyloidogenic effects.	inhibition of beta-amyloid (a beta) accumulation and a beta fibril (fa beta) formation from a beta are attractive therapeutic targets for the treatment of alzheimer's disease (ad). while previous studies have shown anti-amyloidogenic effects of curcumin in vitro and in vivo, no studies have examined optimized turmeric extracts enriched in curcuminoids or turmerones. three standardized turmeric extracts, hss-838, hss-848, and hss-888, were prepared with different chemical profiles to investigate ...	2009	19715544
uncoupling of oxidative phosphorylation by curcumin: implication of its cellular mechanism of action.	curcumin is a phytochemical isolated from the rhizome of turmeric. recent reports have shown curcumin to have antioxidant, anti-inflammatory and anti-tumor properties as well as affecting the 5'-amp activated protein kinase (ampk), mtor and stat-3 signaling pathways. we provide evidence that curcumin acts as an uncoupler. well-established biochemical techniques were performed on isolated rat liver mitochondria in measuring oxygen consumption, f(0)f(1)-atpase activity and atp biosynthesis. curcum ...	2009	19715674
effect of curcumin on nuclear factor kappab signaling pathways in human chronic myelogenous k562 leukemia cells.	curcumin, a natural product isolated from the plant curcuma longa, has a diverse range of molecular targets that influence numerous biochemical and molecular cascades. curcumin has been shown to inhibit nuclear factor kappab (nf-kappab) activation at several steps in the nf-kappab signaling pathways and thereby controls numerous nf-kappab-regulated genes involved in various diseases. in the present study, we investigated the effect of curcumin pretreatment on 84 tumor necrosis factor-alpha (tnf- ...	2009	19723087
curcumin acts as anti-tumorigenic and hormone-suppressive agent in murine and human pituitary tumour cells in vitro and in vivo.	curcumin (diferuloylmethane) is the active ingredient of the spice plant curcuma longa and has been shown to act anti-tumorigenic in different types of tumours. therefore, we have studied its effect in pituitary tumour cell lines and adenomas. proliferation of lactosomatotroph gh3 and somatotroph mtt/s rat pituitary cells as well as of corticotroph att20 mouse pituitary cells was inhibited by curcumin in monolayer cell culture and in colony formation assay in soft agar. fluorescence-activated ce ...	2009	19726538
transient complete atrioventricular block associated with curcumin intake.	curcumin is a polyphenol responsible for the yellow color of turmeric, a curry spice. a large body of evidence showed that curcumin possessed a variety of beneficial activities. we report a case of transient complete atrioventricular block in a 38-year-old man, after intake of curcumin containing pills for on1month. since all other possible causes of conduction disturbance were excluded and causal relation was achieved by re-intake of the same amount of turmeric containing pills, side-effect of ...	2009	19892416
curcumin potentiates the antitumor effects of bacillus calmette-guerin against bladder cancer through the downregulation of nf-kappab and upregulation of trail receptors.	although bacillus calmette-guerin (bcg) intravesical therapy is a standard treatment for bladder cancer, eventual failure of response is a major problem. treatments that can augment bcg therapy are urgently needed. we investigated whether curcumin, a component of curcuma longa (also called turmeric), has potential to improve the current therapy using in vitro and in vivo mbt-2 murine tumor models. we found that curcumin potentiated bcg-induced apoptosis of human bladder cancer cells. bcg stimula ...	2009	19903839
effects of turmeric (curcuma longa) on the expression of hepatic genes associated with biotransformation, antioxidant, and immune systems in broiler chicks fed aflatoxin.	the objective of the present study was to evaluate the efficacy of curcumin, an antioxidant found in turmeric (curcuma longa) powder (tmp), to ameliorate changes in gene expression in the livers of broiler chicks fed aflatoxin b(1) (afb(1)). four pen replicates of 5 chicks each were assigned to each of 4 dietary treatments, which included the following: a) basal diet containing no afb(1) or tmp (control), b) basal diet supplemented with tmp (0.5%) that supplied 74 mg/kg of curcumin, c) basal die ...	2009	19903961
curcumin: from food spice to cancer prevention.	curcumin [1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6 heptadiene-3, 5-dione] is an orange-yellow component of turmeric (curcuma longa), a spice often found in curry powder. it is known to have a variety of biologic and pharmacologic activities, including anti-inflammatory, anti-oxidant, and anticarcinogenic potential. it is a potent inhibitor of cytochrome p450 with capacity to simultaneously induce detoxifying enzymes such as glutathione s-transferase and as such may find application as a chemopr ...	2009	20192567
[preliminary effects of alcohol and curcuma longa upon cyp2e1 and hematotoxicity in benzene-induced mice].	to observe the effects of cyp2e1 enzymatic alteration upon hematotoxicity by benzene poisoning in mice and the interference of alcohol and curcuma longa.	2009	20137700
effect of curcumin on pathogenesis of hamster-opisthorchiasis through apoptosis-related gene expression.	the present study investigated the effect of curcumin, a phenolic compound with yellow color from curcuma longa l., on the expression of the apoptosis-related genes [bax (bcl-2 associated protein x), pkb, p53, mdm2 (mouse double minute 2), caspase 9, c-ski, smad1 and smad4] in hamster opisthorchiasis. on opisthorchis viverrini infection treated with dietary curcumin apoptosis-related gene expression profiles were similar to o. viverrini-infected group, but the expression levels seemed lower. lig ...	2009	20578454
screening of herbal medicines for the recovery of cisplatin-induced nephrotoxicity.	the goal of this study was to quantitatively determine the recovery effects of herbal medicines (hm) on the cisplatin-induced nephrotoxicity. in the present study, the recovery effects of 239 hm on hek 293 cells that had been damaged by cisplatin were evaluated by a mitochondrial activity mts assay. after the first round of screening, candidate hm were selected based on a recovery rate of greater than 20%. the efficacy of the selected herbs was then determined by dose response kinetic analysis. ...	2009	21784004
anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes.	curcumin, a yellow pigment extracted from rhizomes of the plant curcuma longa (turmeric), has been widely used as food additive and also as a herbal medicine throughout asia. the present study was designed to study the pharmacological, biochemical and neurochemical effects of daily administration of curcumin to rats subjected to chronic unpredictable stress. curcumin treatment (20 and 40 mg/kg, i.p., 21 days) significantly reversed the chronic unpredictable stress-induced behavioral (increase im ...	2009	19000708
curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of mmps and upa.	curcumin (cur), a component of turmeric (curcuma longa), has been reported to exhibit antimetastatic activities, but the mechanisms remain unclear. other curcuminoids present in turmeric, demethoxycurcumin (dmc) and bisdemethoxycurcumin (bdmc) have not been investigated whether they exhibit antimetastatic activity to the same extent as curcumin. the regulation of matrix metalloproteinases (mmps) and urokinase plasminogen activator (upa) play important role in cancer cell invasion by cleavage of ...	2009	18495463
curcumin diminishes human osteoclastogenesis by inhibition of the signalosome-associated i kappab kinase.	curcumin is a natural polyphenolic derogate extracted from spice turmeric, exhibiting anti-inflammatory and chemopreventive activities. it was described to interact with the signalosome-associated kinases and the proteasome-ubiquitin system, which both are involved in the osteoclastogenesis. thus, we hypothesized that curcumin could diminish osteoclast differentiation and function.	2009	18766375
inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in alzheimer's disease.	curcuminoids (a mixture of curcumin, bisdemethoxycurcumin and demethoxycurcumin) share vital pharmacological properties possessed by turmeric, a well known curry spice, considered useful in alzheimer's disease (ad). the aim of this study was to evaluate if curcuminoids possess acetylcholinesterase (ache) inhibitory and memory enhancing activities. the in-vitro and ex-vivo models of ache inhibitory activity were used along with morris water maze test to study the effect on memory in rats. curcumi ...	2009	18930076
inhibition of human dendritic cell activation by hydroethanolic but not lipophilic extracts of turmeric (curcuma longa).	turmeric has been extensively utilized in indian and chinese medicine for its immune-modulatory properties. dendritic cells (dcs) are antigen-presenting cells specialized to initiate and regulate immunity. the ability of dcs to initiate immunity is linked to their activation status. the effects of turmeric on human dcs have not been studied. here we show that hydroethanolic (hee) but not lipophilic "supercritical" extraction (sce) of turmeric inhibits the activation of human dcs in response to i ...	2009	19034830
curcumin in combination with visible light inhibits tumor growth in a xenograft tumor model.	it is known that curcumin, a dietary pigment from the plant curcuma longa, inhibits cell proliferation and induces apoptosis in different cell lines; however, the therapeutic benefit is hampered by very low absorption after transdermal or oral application. recent studies from our laboratory have demonstrated that curcumin at low concentrations (0.2-1 microg/ml) offered the described effects only when applied with uva or visible light. nevertheless, the in vivo efficacy of this combination is lac ...	2009	19035461
treatment of hiv-associated diarrhea with curcumin.	curcumin is the organic extract of turmeric and possesses known anti-inflammatory properties. our aim was to explore the utility of curcumin in patients with hiv-associated diarrhea. eight patients with hiv-associated diarrhea were given a mean daily dose of 1,862 mg of curcumin and followed for a mean of 41 weeks. all had resolution of diarrhea and normalization of stool quality in a mean time of 13 +/- 9.3 days. mean number of bowel movements per day dropped from 7 +/- 3.6 to 1.7 +/- 0.5. seve ...	2009	19051018
curcumin suppresses the induction of indoleamine 2,3-dioxygenase by blocking the janus-activated kinase-protein kinase cdelta-stat1 signaling pathway in interferon-gamma-stimulated murine dendritic cells.	indoleamine 2,3-dioxygenase (ido) catalyzes the initial and rate-limiting step in the degradation of tryptophan and is strongly induced in interferon-gamma (ifngamma)-stimulated dendritic cells (dcs). ido has recently been established as a key enzyme in t-cell suppression-mediated immune tolerance to tumors. stat1 phosphorylation appears to play an important role in the control of ido expression by ifngamma, but the precise regulatory mechanism remains obscure. here we present a novel mechanism ...	2009	19075017
an ethnobotanical study of medicinal plants in chandauli district of uttar pradesh, india.	chandauli district is one of the less studied regions of india for its ethnobotanical values. the present paper synthesizes the first report related to the documentation and conservation of ethnomedicinal plants of chandauli district and their socio-economic relationship with the forests and its resources.	2009	19022368
modulation of ovine neutrophil function and apoptosis by standardized extracts of echinacea angustifolia, butea frondosa and curcuma longa.	impaired neutrophil function has been associated with increased infectious diseases in ruminants. attachment of neutrophils to endothelium and superoxide production is critical features of their immune activity. once the infection is cleared, programmed cell death ensures the rapid resolution of inflammation. to develop new natural therapeutics for ruminants, standard extracts of echinacea angustifolia (polinacea), butea frondosa and curcuma longa (curcuvet) were first evaluated on ovine neutrop ...	2009	19128841
study of curcumin and genistein interactions with human serum albumin.	curcumin, the yellow pigment from the rhizoma of curcuma longa, is a widely studied polyphenolic compound which has a variety of biological activity as anti-inflammatory and antioxidative agent. genistein one of the flavonoids found in soybean and chickpeas inhibits dna strand breaks acting as a direct scavenger of reactive oxygen species. human serum albumin (hsa) with high affinity binding sites is a major transporter for delivering several endogenous compounds and drugs in vivo. the aim of th ...	2009	19135819
inhibitory effects of spices and herbs on iron availability.	spices and herbs are extensively used in indigenous diets in tropical regions where prevalence of iron deficiency is still high. they are rich in polyphenolic compounds that are expected to inhibit iron absorption by forming iron complexes in the intestine, making dietary iron less available for absorption. the effects of six spices and herbs (chili pepper, garlic, 'pak kyheng' (thai leafy vegetable), shallot, tamarind, turmeric) and one mixture of spices (curry paste) on iron availability were ...	2009	18651292
application of scion image software to the simultaneous determination of curcuminoids in turmeric (curcuma longa).	curcumin, desmethoxycurcumin and bisdesmethoxycurcumin are bioactive constituents of turmeric (curcuma longa). owing to their different potency, quality control of turmeric based on the content of each curcuminoid is more reliable than that based on total curcuminoids. however, to perform such an assay, high-cost instrument is needed.	2009	18683171
effect of bitter gourd and spent turmeric on glycoconjugate metabolism in streptozotocin-induced diabetic rats.	changes in glycoconjugate metabolism during the development of diabetic complications and their modulation by feeding bitter gourd and spent turmeric as fiber-rich source.	2009	18413160
curcumin reduces the toxic effects of iron loading in rat liver epithelial cells.	iron overload can cause liver toxicity and increase the risk of liver failure or hepatocellular carcinoma in humans. curcumin (diferuloylmethane), a component of the food spice turmeric, has antioxidant, iron binding and hepatoprotective properties. the aim of this study was to quantify its effects on iron overload and the resulting downstream toxic effects in cultured t51b rat liver epithelial cells.	2009	18492020
potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases.	although safe in most cases, ancient treatments are ignored because neither their active component nor their molecular targets are well defined. this is not the case, however, with curcumin, a yellow-pigment substance and component of turmeric (curcuma longa), which was identified more than a century ago. for centuries it has been known that turmeric exhibits anti-inflammatory activity, but extensive research performed within the past two decades has shown that this activity of turmeric is due t ...	2009	18662800
developing curcumin into a viable therapeutic for lymphoma.	emerging evidence suggests that natural plant ingredients have played an important role in the healthcare of many countries. several of these natural plant products possess therapeutic potential for various diseases including cancer. curcumin is the pigment of turmeric, a well-known chemopreventive agent that has been shown to suppress the proliferation of a wide variety of tumor cells, including lymphoma. curcumin has been shown to have cancer chemopreventive potential against a variety of tumo ...	2009	19053882